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Gene Dmel\Aldh-III

General Information
Symbol	Dmel\Aldh-III	Species	D. melanogaster
Name	Aldehyde dehydrogenase type III	Annotation symbol	CG11140
Feature type	protein_coding_gene	FlyBase ID	FBgn0010548
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	l(2)03610
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	43C4-43C4	Sequence location	2R:3,354,384..3,364,667 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Aldehyde dehydrogenase type III is referred to in FlyBase by the symbol Dmel\Aldh-III (CG11140, FBgn0010548). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; cellular aldehyde metabolic process. 12 alleles are reported. The phenotype of these alleles is annotated with: crystal cell. It has 13 annotated transcripts and 13 annotated polypeptides. Protein features are: Aldehyde dehydrogenase NAD(P)-dependent; Aldehyde dehydrogenase domain; Aldehyde dehydrogenase, C-terminal; Aldehyde dehydrogenase, N-terminal; Aldehyde dehydrogenase, conserved site; Aldehyde/histidinol dehydrogenase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval midgut, adult heart, adult fat body, larval salivary gland, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, adult salivary gland, larval trachea, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627861_s_at completely aligns to an exonic region common to each of the 8 FlyBase-annotated transcript isoforms of Aldh-III. Gene sequence location is 2R:3354384..3364667.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43C4-43C4   Limits computationally determined from genome sequence between P{lacW}cosk16101 and P{EP}CG1600EP398
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43D1-43D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 43D1-43D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Aldh-III for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Aldh-III-RE FBtr0088996  NM_206050   1840   497 Aldh-III-RI FBtr0088993  NM_165526   2305   498 Aldh-III-RK FBtr0300477  NM_165530   2233   498 Aldh-III-RL FBtr0300478  NM_165527   2144   498 Aldh-III-RM FBtr0300479  NM_165529   2052   498 Aldh-III-RN FBtr0300480  NM_165532   2352   563 Aldh-III-RO FBtr0300481  NM_165531   2448   563 Aldh-III-RP FBtr0310674  NM_136441   2306   563 Aldh-III-RQ FBtr0308198  NM_165528   2923   564 Aldh-III-RR FBtr0310675  NM_001273843   1840   497 Aldh-III-RS FBtr0310676  NM_001273844   2233   498 Aldh-III-RT FBtr0310677  NM_001273845   1840   497 Aldh-III-RU FBtr0336912  NM_001273846   2115   501
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Aldh-III-PE   FBpp0089176   55.7   497   7.86     NP_995772   AAM68898 Aldh-III-PI   FBpp0088066   55.7   498   7.14     NP_724560   AAM68895 Aldh-III-PK   FBpp0289704   55.7   498   7.14     NP_724564   AAM68897 Aldh-III-PL   FBpp0289705   55.7   498   7.14     NP_724561   AAF59248 Aldh-III-PM   FBpp0289706   55.7   498   7.14     NP_724563   AAM68896 Aldh-III-PN   FBpp0289707   62.9   563   5.56     NP_724566   AAM68900 Aldh-III-PO   FBpp0289708   63.0   563   6.44     NP_724565   AAM68899 Aldh-III-PP   FBpp0302794   62.8   563   5.30     NP_610285   AAM68894 Aldh-III-PQ   FBpp0300518   63.0   564   6.44     NP_724562   AAF59247 Aldh-III-PR   FBpp0302795   55.6   497   6.70     NP_001260772   AGB93305 Aldh-III-PS   FBpp0302796   55.8   498   8.18     NP_001260773   AGB93306 Aldh-III-PT   FBpp0302797   55.6   497   6.70     NP_001260774   AGB93307 Aldh-III-PU   FBpp0307851   56.2   501   8.44     NP_001260775   AGB93308
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aldehyde dehydrogenase NAD(P)-dependent (IPR012394) Aldehyde dehydrogenase domain (IPR015590) Aldehyde dehydrogenase, conserved site (IPR016160) Aldehyde/histidinol dehydrogenase (IPR016161) Aldehyde dehydrogenase, N-terminal (IPR016162) Aldehyde dehydrogenase, C-terminal (IPR016163)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202392   AA263348   AA263593   AA438426   AA439596   AA697176   AA816360   AA820094   AA820097   AA952272   AA978659   AA979553   AE013599 AAF59247   AE013599 AAF59248   AE013599 AAM68894   AE013599 AAM68895   AE013599 AAM68896   AE013599 AAM68897   AE013599 AAM68898   AE013599 AAM68899   AE013599 AAM68900   AE013599 AGB93305   AE013599 AGB93306   AE013599 AGB93307   AE013599 AGB93308   AI061729   AI238990   AI295962   AI389626   AI405509   AI405581   AI405602   AI512486   AI515693   AI532398   AI534254   AI543242   AI543250   AW940984   AY069199 AAL39344   BF501028   BF504896   BG638554   BG638672   BI171300   BI171388   BI233118   BI235118   BI235539   BI365561   BI370991   BI482820   BI578543   BI579400   BI582769   BI582788   BI588457   BI588906   BI626762   BI637931   BI639779   BI641449   BI641767   BP542428   BQ103014   BT001784 AAN71539   BT003248 AAO25005   BT003252 AAO25009   BT044325   BT124830   BT125739   BT126071   CA806399   CK659790   CL844490   CO187200   CO263763   CO264005   CO271135   CO282158   CO288233   CO294227   CO302577   CO307207   CO312750   CO314698   CO315658   CO316222   CO321836   CO323466   CO330220   CO331153   CO339616   CZ467813   CZ468657   CZ469191   CZ478026   CZ478769   EC059394   EC062059   EC067401   EC070132   EC080403   EC082965   EC085766   EC202491   EC203849   EC208360   EC209861   EC214253   EC221211   EC226413   EC236063   EC246566   EL872826   EL878347   EL878474   EL881256   EL881257   EL881370   EV575839   EV577990   G00524
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z6Z3 Q7JR61 A1Z6Z4 A4UZ69 Q8T0K8 Q8IGH3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal ridge primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) dorsal ridge   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012) lateral head epidermis   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval midgut, adult heart, adult fat body, larval salivary gland, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, adult salivary gland, larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut    642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland    581.8 Larval Trachea    213.125 Larval Carcass    552.15 Adult Head    574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop    687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body    1140.4 Adult Salivary Gland    296.2 Adult Heart    900.325 Adult VirginFemale Spermatheca    696 Adult InseminatedFemale Spermatheca    624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass    864.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut  (642.6) Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland  (581.8) Larval Trachea    213.125 Larval Carcass  (552.15) Adult Head  (574.6) Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop  (687.5) Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body  (1140.4) Adult Salivary Gland    296.2 Adult Heart  (900.325) Adult VirginFemale Spermatheca  (696) Adult InseminatedFemale Spermatheca  (624) Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass  (864.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut    642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland    581.8 Larval Trachea    213.125 Larval Carcass    552.15 Adult Head    574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop    687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body  (1140.4) Adult Salivary Gland    296.2 Adult Heart    900.325 Adult VirginFemale Spermatheca    696 Adult InseminatedFemale Spermatheca    624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass    864.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut    642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland    581.8 Larval Trachea    213.125 Larval Carcass    552.15 Adult Head    574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop    687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body    1140.4 Adult Salivary Gland    296.2 Adult Heart    900.325 Adult VirginFemale Spermatheca    696 Adult InseminatedFemale Spermatheca    624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass    864.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut    642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland    581.8 Larval Trachea    213.125 Larval Carcass    552.15 Adult Head    574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop    687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body    1140.4 Adult Salivary Gland    296.2 Adult Heart    900.325 Adult VirginFemale Spermatheca    696 Adult InseminatedFemale Spermatheca    624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass    864.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut  642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland  581.8 Larval Trachea    213.125 Larval Carcass  552.15 Adult Head  574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop  687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body  (1140.4) Adult Salivary Gland    296.2 Adult Heart  (900.325) Adult VirginFemale Spermatheca  696 Adult InseminatedFemale Spermatheca  624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass  (864.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut    642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland    581.8 Larval Trachea    213.125 Larval Carcass    552.15 Adult Head    574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop    687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body  1140.4 Adult Salivary Gland    296.2 Adult Heart    900.325 Adult VirginFemale Spermatheca    696 Adult InseminatedFemale Spermatheca    624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass    864.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.025 Larval Midgut    642.6 Larval Hindgut    189.6 Larval Malpighian Tubules    385.8 Larval Fat Body    489.5 Larval Salivary Gland    581.8 Larval Trachea    213.125 Larval Carcass    552.15 Adult Head    574.6 Adult Eye    304.05 Adult Brain    205.5 Adult Thoracic-Abdominal Ganglion    202.6 Adult Crop    687.5 Adult Midgut    274.3 Adult Hindgut    457 Adult Malpighian Tubules    303.6 Adult Fat Body    1140.4 Adult Salivary Gland    296.2 Adult Heart    900.325 Adult VirginFemale Spermatheca    696 Adult InseminatedFemale Spermatheca    624 Adult Ovary    100.7 Adult Testis    218.5 Adult Male Accessory Gland    97.2 Adult Carcass    864.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    574.6   NA  Eye    304.05   NA  Brain    205.5   142.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    202.6   NA  Crop    687.5   642.6  Midgut    274.3   189.6  Hindgut    457   385.8  Malpighian Tubules    303.6   489.5  Fat Body    1140.4   581.8  Salivary Gland    296.2   NA  Heart    900.325   213.125  Trachea    NA   NA  VirginFemale Spermatheca    696   NA  InseminatedFemale Spermatheca    624   NA  Ovary    100.7   NA  Testis    218.5   NA  Male Accessory Gland    97.2   552.15  Carcass    864.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    41 central nervous system, pupae P8    32 head, virgin 1-day female    49 head, virgin 4-day female    40 head, virgin 20-day female    38 head, mated 1-day female    45 head, mated 4-day female    39 head, mated 20-day female    37 head, mated 1-day male    77 head, mated 4-day male    72 head, mated 20-day male    79 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    42 digestive system, 4-day adult    46 digestive system, 20-day adult    33 fat body, larvae L3 wandering    34 fat body, white prepupae    45 fat body, pupae P8    125 carcass, larvae L3 wandering    57 carcass, 1-day adult    75 carcass, 4-day adult    82 carcass, 20-day adult    80 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    44 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (41) central nervous system, pupae P8  (32) head, virgin 1-day female  (49) head, virgin 4-day female  (40) head, virgin 20-day female  (38) head, mated 1-day female  (45) head, mated 4-day female  (39) head, mated 20-day female  (37) head, mated 1-day male  (77) head, mated 4-day male  (72) head, mated 20-day male  (79) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering  (32) digestive system, 1-day adult  (42) digestive system, 4-day adult  (46) digestive system, 20-day adult  (33) fat body, larvae L3 wandering  (34) fat body, white prepupae  (45) fat body, pupae P8  (125) carcass, larvae L3 wandering  (57) carcass, 1-day adult  (75) carcass, 4-day adult  (82) carcass, 20-day adult  (80) ovary, virgin 4-day female  (44) ovary, mated 4-day female  (40) testis, mated 4-day male  (44) accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    41 central nervous system, pupae P8    32 head, virgin 1-day female    49 head, virgin 4-day female    40 head, virgin 20-day female    38 head, mated 1-day female    45 head, mated 4-day female    39 head, mated 20-day female    37 head, mated 1-day male    77 head, mated 4-day male    72 head, mated 20-day male    79 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    42 digestive system, 4-day adult    46 digestive system, 20-day adult    33 fat body, larvae L3 wandering    34 fat body, white prepupae    45 fat body, pupae P8  (125) carcass, larvae L3 wandering    57 carcass, 1-day adult    75 carcass, 4-day adult    82 carcass, 20-day adult    80 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    44 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    41 central nervous system, pupae P8    32 head, virgin 1-day female    49 head, virgin 4-day female    40 head, virgin 20-day female    38 head, mated 1-day female    45 head, mated 4-day female    39 head, mated 20-day female    37 head, mated 1-day male    77 head, mated 4-day male    72 head, mated 20-day male    79 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    42 digestive system, 4-day adult    46 digestive system, 20-day adult    33 fat body, larvae L3 wandering    34 fat body, white prepupae    45 fat body, pupae P8    125 carcass, larvae L3 wandering    57 carcass, 1-day adult    75 carcass, 4-day adult    82 carcass, 20-day adult    80 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    44 accessory gland, mated 4-day male    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    41 central nervous system, pupae P8    32 head, virgin 1-day female    49 head, virgin 4-day female    40 head, virgin 20-day female    38 head, mated 1-day female    45 head, mated 4-day female    39 head, mated 20-day female    37 head, mated 1-day male    77 head, mated 4-day male    72 head, mated 20-day male    79 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    42 digestive system, 4-day adult    46 digestive system, 20-day adult    33 fat body, larvae L3 wandering    34 fat body, white prepupae    45 fat body, pupae P8    125 carcass, larvae L3 wandering    57 carcass, 1-day adult    75 carcass, 4-day adult    82 carcass, 20-day adult    80 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    44 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (41) central nervous system, pupae P8  32 head, virgin 1-day female  (49) head, virgin 4-day female  (40) head, virgin 20-day female  (38) head, mated 1-day female  (45) head, mated 4-day female  (39) head, mated 20-day female  (37) head, mated 1-day male  (77) head, mated 4-day male  (72) head, mated 20-day male  (79) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering  32 digestive system, 1-day adult  (42) digestive system, 4-day adult  (46) digestive system, 20-day adult  (33) fat body, larvae L3 wandering  (34) fat body, white prepupae  (45) fat body, pupae P8  (125) carcass, larvae L3 wandering  (57) carcass, 1-day adult  (75) carcass, 4-day adult  (82) carcass, 20-day adult  (80) ovary, virgin 4-day female  (44) ovary, mated 4-day female  (40) testis, mated 4-day male  (44) accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    41 central nervous system, pupae P8    32 head, virgin 1-day female    49 head, virgin 4-day female    40 head, virgin 20-day female    38 head, mated 1-day female    45 head, mated 4-day female    39 head, mated 20-day female    37 head, mated 1-day male    77 head, mated 4-day male    72 head, mated 20-day male    79 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    42 digestive system, 4-day adult    46 digestive system, 20-day adult    33 fat body, larvae L3 wandering    34 fat body, white prepupae    45 fat body, pupae P8  125 carcass, larvae L3 wandering    57 carcass, 1-day adult    75 carcass, 4-day adult    82 carcass, 20-day adult    80 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    44 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    41 central nervous system, pupae P8    32 head, virgin 1-day female    49 head, virgin 4-day female    40 head, virgin 20-day female    38 head, mated 1-day female    45 head, mated 4-day female    39 head, mated 20-day female    37 head, mated 1-day male    77 head, mated 4-day male    72 head, mated 20-day male    79 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    42 digestive system, 4-day adult    46 digestive system, 20-day adult    33 fat body, larvae L3 wandering    34 fat body, white prepupae    45 fat body, pupae P8    125 carcass, larvae L3 wandering    57 carcass, 1-day adult    75 carcass, 4-day adult    82 carcass, 20-day adult    80 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    44 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    35 embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr    31 embryo 12-14hr    35 embryo 14-16hr    60 embryo 16-18hr    58 embryo 18-20hr    62 embryo 20-22hr    60 embryo 22-24hr    66 larva L1    60 larva L2    62 larva L3 12hr old    61 larva L3 puffstage 1-2    51 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    76 white prepupae 24hr    63 pupae 2d postWPP    47 pupae 3d postWPP    39 pupae 4d postWPP    39 adult male 01day    67 adult male 05day    73 adult male 30day    63 adult female 01day    36 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (35) embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr  (31) embryo 12-14hr  (35) embryo 14-16hr  (60) embryo 16-18hr  (58) embryo 18-20hr  (62) embryo 20-22hr  (60) embryo 22-24hr  (66) larva L1  (60) larva L2  (62) larva L3 12hr old  (61) larva L3 puffstage 1-2  (51) larva L3 puffstage 3-6  (46) larva L3 puffstage 7-9  (39) white prepupae new  (35) white prepupae 12hr  (76) white prepupae 24hr  (63) pupae 2d postWPP  (47) pupae 3d postWPP  (39) pupae 4d postWPP  (39) adult male 01day  (67) adult male 05day  (73) adult male 30day  (63) adult female 01day  (36) adult female 05day  (32) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    35 embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr    31 embryo 12-14hr    35 embryo 14-16hr    60 embryo 16-18hr    58 embryo 18-20hr    62 embryo 20-22hr    60 embryo 22-24hr    66 larva L1    60 larva L2    62 larva L3 12hr old    61 larva L3 puffstage 1-2    51 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    76 white prepupae 24hr    63 pupae 2d postWPP    47 pupae 3d postWPP    39 pupae 4d postWPP    39 adult male 01day    67 adult male 05day    73 adult male 30day    63 adult female 01day    36 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    35 embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr    31 embryo 12-14hr    35 embryo 14-16hr    60 embryo 16-18hr    58 embryo 18-20hr    62 embryo 20-22hr    60 embryo 22-24hr    66 larva L1    60 larva L2    62 larva L3 12hr old    61 larva L3 puffstage 1-2    51 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    76 white prepupae 24hr    63 pupae 2d postWPP    47 pupae 3d postWPP    39 pupae 4d postWPP    39 adult male 01day    67 adult male 05day    73 adult male 30day    63 adult female 01day    36 adult female 05day    32 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    35 embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr    31 embryo 12-14hr    35 embryo 14-16hr    60 embryo 16-18hr    58 embryo 18-20hr    62 embryo 20-22hr    60 embryo 22-24hr    66 larva L1    60 larva L2    62 larva L3 12hr old    61 larva L3 puffstage 1-2    51 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    76 white prepupae 24hr    63 pupae 2d postWPP    47 pupae 3d postWPP    39 pupae 4d postWPP    39 adult male 01day    67 adult male 05day    73 adult male 30day    63 adult female 01day    36 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (35) embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr  31 embryo 12-14hr  (35) embryo 14-16hr  (60) embryo 16-18hr  (58) embryo 18-20hr  (62) embryo 20-22hr  (60) embryo 22-24hr  (66) larva L1  (60) larva L2  (62) larva L3 12hr old  (61) larva L3 puffstage 1-2  (51) larva L3 puffstage 3-6  (46) larva L3 puffstage 7-9  (39) white prepupae new  (35) white prepupae 12hr  (76) white prepupae 24hr  (63) pupae 2d postWPP  (47) pupae 3d postWPP  (39) pupae 4d postWPP  (39) adult male 01day  (67) adult male 05day  (73) adult male 30day  (63) adult female 01day  (36) adult female 05day  32 adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    35 embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr    31 embryo 12-14hr    35 embryo 14-16hr    60 embryo 16-18hr    58 embryo 18-20hr    62 embryo 20-22hr    60 embryo 22-24hr    66 larva L1    60 larva L2    62 larva L3 12hr old    61 larva L3 puffstage 1-2    51 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    76 white prepupae 24hr    63 pupae 2d postWPP    47 pupae 3d postWPP    39 pupae 4d postWPP    39 adult male 01day    67 adult male 05day    73 adult male 30day    63 adult female 01day    36 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    35 embryo 04-06hr    15 embryo 06-08hr    11 embryo 08-10hr    19 embryo 10-12hr    31 embryo 12-14hr    35 embryo 14-16hr    60 embryo 16-18hr    58 embryo 18-20hr    62 embryo 20-22hr    60 embryo 22-24hr    66 larva L1    60 larva L2    62 larva L3 12hr old    61 larva L3 puffstage 1-2    51 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    76 white prepupae 24hr    63 pupae 2d postWPP    47 pupae 3d postWPP    39 pupae 4d postWPP    39 adult male 01day    67 adult male 05day    73 adult male 30day    63 adult female 01day    36 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    30 embryonic 1182-4H    110 embryonic GM2    74 embryonic Kc167    35 embryonic S1    37 embryonic S3    105 leg disc CME L1    36 wing disc CME-W2    39 wing disc ML-DmD8    40 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    270 wing disc ML-DmD21    27 wing disc ML-DmD32    124 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    98 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    75 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    73 tumorous blood cells mbn2    67 ovary fGS/OSS    33 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  (30) embryonic 1182-4H  (110) embryonic GM2  (74) embryonic Kc167  (35) embryonic S1  (37) embryonic S3  (105) leg disc CME L1  (36) wing disc CME-W2  (39) wing disc ML-DmD8  (40) wing disc ML-DmD9  (72) wing disc ML-DmD16-c3  (270) wing disc ML-DmD21  (27) wing disc ML-DmD32  (124) haltere disc ML-DmD17-c3  (29) eye-antennal disc ML-DmD11  (98) antennal disc ML-DmD20-c5  (92) mixed discs ML-DmD4-c1  (75) CNS ML-DmBG1-c1  (28) CNS ML-DmBG2-c2  (73) tumorous blood cells mbn2  (67) ovary fGS/OSS  (33) ovary OSC  (30) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    30 embryonic 1182-4H  (110) embryonic GM2    74 embryonic Kc167    35 embryonic S1    37 embryonic S3  105 leg disc CME L1    36 wing disc CME-W2    39 wing disc ML-DmD8    40 wing disc ML-DmD9    72 wing disc ML-DmD16-c3  (270) wing disc ML-DmD21    27 wing disc ML-DmD32  (124) haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    98 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    75 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    73 tumorous blood cells mbn2    67 ovary fGS/OSS    33 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    30 embryonic 1182-4H    110 embryonic GM2    74 embryonic Kc167    35 embryonic S1    37 embryonic S3    105 leg disc CME L1    36 wing disc CME-W2    39 wing disc ML-DmD8    40 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    270 wing disc ML-DmD21    27 wing disc ML-DmD32    124 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    98 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    75 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    73 tumorous blood cells mbn2    67 ovary fGS/OSS    33 ovary OSC    30 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    30 embryonic 1182-4H    110 embryonic GM2    74 embryonic Kc167    35 embryonic S1    37 embryonic S3    105 leg disc CME L1    36 wing disc CME-W2    39 wing disc ML-DmD8    40 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    270 wing disc ML-DmD21    27 wing disc ML-DmD32    124 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    98 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    75 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    73 tumorous blood cells mbn2    67 ovary fGS/OSS    33 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  30 embryonic 1182-4H  (110) embryonic GM2  (74) embryonic Kc167  (35) embryonic S1  (37) embryonic S3  (105) leg disc CME L1  (36) wing disc CME-W2  (39) wing disc ML-DmD8  (40) wing disc ML-DmD9  (72) wing disc ML-DmD16-c3  (270) wing disc ML-DmD21  27 wing disc ML-DmD32  (124) haltere disc ML-DmD17-c3  29 eye-antennal disc ML-DmD11  (98) antennal disc ML-DmD20-c5  (92) mixed discs ML-DmD4-c1  (75) CNS ML-DmBG1-c1  28 CNS ML-DmBG2-c2  (73) tumorous blood cells mbn2  (67) ovary fGS/OSS  (33) ovary OSC  30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    30 embryonic 1182-4H  110 embryonic GM2    74 embryonic Kc167    35 embryonic S1    37 embryonic S3  105 leg disc CME L1    36 wing disc CME-W2    39 wing disc ML-DmD8    40 wing disc ML-DmD9    72 wing disc ML-DmD16-c3  (270) wing disc ML-DmD21    27 wing disc ML-DmD32  124 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    98 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    75 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    73 tumorous blood cells mbn2    67 ovary fGS/OSS    33 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    30 embryonic 1182-4H    110 embryonic GM2    74 embryonic Kc167    35 embryonic S1    37 embryonic S3    105 leg disc CME L1    36 wing disc CME-W2    39 wing disc ML-DmD8    40 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    270 wing disc ML-DmD21    27 wing disc ML-DmD32    124 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    98 antennal disc ML-DmD20-c5    92 mixed discs ML-DmD4-c1    75 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    73 tumorous blood cells mbn2    67 ovary fGS/OSS    33 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    48 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    51 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    43 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    67 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    23 heat shock, 4-day adult  (48) Cadmium 50 mM 6 hrs, larvae L3  (65) Cadmium 50 mM 12 hrs, larvae L3  (54) Cadmium 50 mM 48 hrs, 4-day adult  (51) Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3  (43) Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  (30) Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3  (57) Ethanol 10% 3 hrs, larvae L3  (52) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (67) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult  (30) Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (48) Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    48 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    51 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    43 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    67 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    48 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    51 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    43 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    67 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    61 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    48 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    51 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    43 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    67 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    23 heat shock, 4-day adult  (48) Cadmium 50 mM 6 hrs, larvae L3  (65) Cadmium 50 mM 12 hrs, larvae L3  (54) Cadmium 50 mM 48 hrs, 4-day adult  (51) Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3  (43) Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  30 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3  (57) Ethanol 10% 3 hrs, larvae L3  (52) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (67) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult  30 Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (48) Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    48 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    51 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    43 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    67 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    23 heat shock, 4-day adult    48 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    51 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    43 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    67 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • PC00149 LD29384 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010548 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11140-RH FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Aldh-III Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Aldh-III03610 Aldh-III05467 partially lethal - majority die Aldh-III03610 viable, with Scer\GAL4pnr-MD237 Aldh-IIIGD4527 Other Phenotypes Allele behavior defective Aldh-III03610 chemical sensitive Aldh-III03610 Phenotype manifest in Allele crystal cell Aldh-III03610
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Aldh-III Class Mutagen Stocks Known lesion Aldh-III03610 P-element activity 1 -- Aldh-IIIc02262 piggyBac transposase 1 -- Aldh-IIIc03465 piggyBac transposase 1 -- Aldh-IIIc04338 piggyBac transposase 1 -- Aldh-IIIe00128 piggyBac transposase 1 -- Aldh-IIIEY12056 P-element activity 1 -- Aldh-IIIMI00204 1 -- Aldh-III05467 P-element activity 0 -- Aldh-IIIe00937 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aldh-III Class Mutagen Stocks Known lesion Aldh-IIIGD4527 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Aldh-IIIKK109404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Aldh-IIIdsRNA.cDa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC264 (Christensen and Cook, 2007.3.22) Df(2R)nap16 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)pk78s (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)ST1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)cn9 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)pk78k (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4527} NA P{KK109404} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Aldh-IIIMI00204 NA PBac{PB}Aldh-IIIc02262 NA PBac{PB}Aldh-IIIc03465 NA PBac{PB}Aldh-IIIc04338 NA PBac{RB}Aldh-IIIe00128 NA PBac{RB}Aldh-IIIe00937 NA insertion of mobile activating element P{EPgy2}Aldh-IIIEY12056 NA insertion of enhancer trap P{PZ}Aldh-III03610 No P{PZ}Aldh-III05467 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
aldehyde dehydrogenase [NAD(P)+] activity inferred from electronic annotation with InterPro:IPR012394 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor inferred from sequence or structural similarity with mouse Aldh3a1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cellular aldehyde metabolic process inferred from electronic annotation with InterPro:IPR012394 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR012394, InterPro:IPR015590, InterPro:IPR016160, InterPro:IPR016161, InterPro:IPR016162, InterPro:IPR016163 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Aldh-III - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG1129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG11777 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG12343 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG30467 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Ccs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Cg25C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - CoVb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - gish anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - snama anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - sun anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - vkg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aldh-III - vlc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aldh-III allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69653 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010548 DroID - A comprehensive database of gene and protein interactions. • FBgn0010548 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45398
Orthologs
OrthoDB Orthologs (66) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZGPXW Dipteran inclusive ortholog search EOG62RDGM Insect inclusive ortholog search EOG6VT4SD Arthropod inclusive ortholog search EOG6X69QG Metazoa inclusive ortholog search EOG6NWBCM
Orthologs in Drosophila Species (EOG6ZGPXW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Aldh-III     Drosophila simulans   Dsim\GD10252 Y   Drosophila sechellia   Dsec\GM20791 Y   Drosophila erecta   Dere\GG10745 Y   Drosophila yakuba   Dyak\GE23970 Y   Drosophila ananassae   Dana\GF13679 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24936 Y   Drosophila persimilis   Dper\GL20120 Y   Drosophila willistoni   Dwil\GK10705 Y   Drosophila virilis   Dvir\GJ18456 Y   Drosophila mojavensis   Dmoj\GI19798 Y   Drosophila grimshawi   Dgri\GH20599 Y
Orthologs in non-Drosophila Dipterans (EOG62RDGM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012165   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012162   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009664   Anopheles gambiae Malaria mosquito  Agam\AGAP005124   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002285   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002286
Orthologs in non-Dipteran Insects (EOG6VT4SD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53314   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013066   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15297   Atta cephalotes Leafcutter ant  Acep\ACEP16592   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21010   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10865   Linepithema humile Argentine ant  Lhum\LH16847   Linepithema humile Argentine ant  Lhum\LH12717   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12654   Solenopsis invicta Red fire ant  Sinv\SINV10949   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008933   Bombyx mori Silkmoth  Bmor\BGIBMGA001965   Bombyx mori Silkmoth  Bmor\BGIBMGA001966   Pediculus humanus Human body louse  Phum\PHUM593980   Tribolium castaneum Red flour beetle  Tcas\TC015978   Tribolium castaneum Red flour beetle  Tcas\TC015979   Tribolium castaneum Red flour beetle  Tcas\TC005624   Tribolium castaneum Red flour beetle  Tcas\TC005623   Tribolium castaneum Red flour beetle  Tcas\TC015980   Tribolium castaneum Red flour beetle  Tcas\TC005625
Orthologs in non-Insect Arthropods (EOG6X69QG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CDC2   Ixodes scapularis Deer tick  Isca\ISCW012534
Orthologs in non-Arthropod Metazoa (EOG6NWBCM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\alh-5   Caenorhabditis elegans Nematode  Cele\alh-4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012642gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009853gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026212gn   Danio rerio Zebrafish  Drer\zgc:103715   Danio rerio Zebrafish  Drer\aldh3d1   Danio rerio Zebrafish  Drer\si:dkey-189p24.4   Danio rerio Zebrafish  Drer\CR848784.2   Danio rerio Zebrafish  Drer\aldh3a2   Xenopus tropicalis Western clawed frog  Xtro\aldh3b1   Xenopus tropicalis Western clawed frog  Xtro\aldh3a2   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000012447   Gallus gallus Domestic chicken  Ggal\ALDH3B1   Gallus gallus Domestic chicken  Ggal\ALDH3A2   Mus musculus House mouse  Mmus\Aldh3b2   Mus musculus House mouse  Mmus\Aldh3a2   Mus musculus House mouse  Mmus\Aldh3b1   Mus musculus House mouse  Mmus\Aldh3a1   Rattus norvegicus Norway rat  Rnor\Aldh3b2   Rattus norvegicus Norway rat  Rnor\LOC100365083   Rattus norvegicus Norway rat  Rnor\Aldh3a2   Rattus norvegicus Norway rat  Rnor\Aldh3a1   Rattus norvegicus Norway rat  Rnor\Aldh3b1   Homo sapiens Human  Hsap\ALDH3A1   Homo sapiens Human  Hsap\ALDH3B2
Human Orthologs (2)
Gene OMIM HGNC Hsap\ALDH3A1     Hsap\ALDH3B2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10252 Drosophila sechellia Dsec\GM20791 Drosophila erecta Dere\GG10745 Drosophila yakuba Dyak\GE23970 Drosophila ananassae Dana\GF13679 Drosophila pseudoobscura pseudoobscura Dpse\GA24936 Drosophila persimilis Dper\GL20120 Drosophila willistoni Dwil\GK10705 Drosophila virilis Dvir\GJ18456 Drosophila mojavensis Dmoj\GI19798 Drosophila grimshawi Dgri\GH20599
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	11342 P{PZ}Aldh-III03610 cn1/CyO; ry506 30662 y1 w*; Mi{MIC}Aldh-IIIMI00204/CyO 20339 y1 w67c23; P{EPgy2}Aldh-IIIEY12056/CyO
Harvard	- PBac{PB}Aldh-IIIc02262 - PBac{PB}Aldh-IIIc03465 - PBac{PB}Aldh-IIIc04338 - PBac{RB}Aldh-IIIe00128
VDRC	v107110 P{KK109404}VIE-260B v37726 w1118; P{GD4527}v37726
Genomic Clones ( 1 )
	BACR04G20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 95 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25629 LD29384 LD32628 RE08771 RH21091
Other clones	DPiM_LD29384 FI07249 MIP22223 MIP27310
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07011 AT16222 GH15151 GH20849 GH25529 GH25664 GM09273 LD01262 LD02207 LD06491 LD06916 LD12509 LD14207 LD22269 LD22280 LD34170 LD34818 LD41335 LD44374 LP09740 LP17801 RE13043 RE13146 RE29403 RE30928 RE31394 RE50918 RE57783 RE65583 RE72424 RE73427 RH21071 RH29687 RH30364 RH67814 SD03903 SD07021 SD09941 SD09953 SD20104 SD22453 SD24788 SD25375
Other clones	29288 31275 44385 59467 63820 78695 104825 118319 148435 157068 191532 CK01.30C.C6 CK01.86A.H1 CK01.107B.F4 CK01.167A.E12 Dmel_dig_018732_0674_1086 Dmel_dig_019045_0676_2485 EK027130 EK068029 EK089554 EK102052 EK137135 EK159651 EK184461 EK186504 EK190531 EK206354 EK229911 EK237456 EK253937 EK262124 EK264003 EK294738 EK298649 EP02407 ESG013a.E21.1_G04 FGC013A10 IP04679 IP08221 IP08321 IP11055 IP11155 UUGC0410
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010548 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45398
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Aldh-III CG11140 (Levis, 2002.4.4)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136441 NM_165526 NM_165527 NM_165528 NM_165529 NM_165530 NM_165531 NM_165532 NM_206050 NM_001273843 NM_001273844 NM_001273845 NM_001273846 RefSeq (Proteins) • NP_610285 NP_724560 NP_724561 NP_724562 NP_724563 NP_724564 NP_724565 NP_724566 NP_995772 NP_001260772 NP_001260773 NP_001260774 NP_001260775 DDBJ / EMBL / GenBank • AA202392 AA952272 AA978659 AAF59247 AAF59248 AAL39344 AAM68894 AAM68895 AAM68896 AAM68897 AAM68898 AAM68899 AAM68900 AAN71539 AAO25005 AAO25009 AGB93305 AGB93306 AGB93307 AGB93308 AI405581 AW940984 AY069199 BG638554 BG638672 BI582788 BT001784 BT003248 BT003252 CL844490 CZ467813 CZ468657 CZ469191 CZ478026 CZ478769 G00524 Entrez Gene - A searchable database of RefSeq genes. • 45398 UniProtKB/TrEMBL • A1Z6Z3 A1Z6Z4 A4UZ69 Q7JR61 Q8IGH3 Q8T0K8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aldehyde dehydrogenase NAD(P)-dependent (IPR012394) Aldehyde dehydrogenase domain (IPR015590) Aldehyde dehydrogenase, conserved site (IPR016160) Aldehyde/histidinol dehydrogenase (IPR016161) Aldehyde dehydrogenase, N-terminal (IPR016162) Aldehyde dehydrogenase, C-terminal (IPR016163) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD29384 PC00149
Linkouts
	BioGRID - A database of protein and genetic interactions • 69653 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010548 DroID - A comprehensive database of gene and protein interactions. • FBgn0010548 DRSC - Results from RNAi screens. • FBgn0010548 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010548 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11140-RH FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010548 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45398 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45398 modMine - Data generated by the modENCODE project. • FBgn0010548
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	ALDH-III (Milchanowski et al., 2004) Aldh-III (Beller et al., 2006, Christensen and Cook, 2007.3.22, Quinones-Coello, 2007, Alic et al., 2011, Arthaud et al., 2011) CG11140 (Dobrosotskaya et al., 2002, Quinones-Coello, 2007, Mosallanejad et al., 2010, Arthaud et al., 2011, Keleman et al., 2009.8.5, Seinen et al., 2010, Cammarato et al., 2011) CT41571 (Ceriani et al., 2002) Dhap (Spradling et al., 1999) FALDH (Dobrosotskaya et al., 2002) l(2)03610 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, )
Name Synonym	Aldehyde dehydrogenase type III (Spradling et al., 1999, Cammarato et al., 2011) Fatty aldehyde dehydrogenase (Dobrosotskaya et al., 2002) Fatty Aldehyde Dehydrogenase (Dobrosotskaya et al., 2002)
Secondary FlyBase IDs
	FBgn0033180
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 13 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Alic et al., 2011, Mol. Syst. Biol. 7: 502 Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. [FBrf0214014] Arthaud et al., 2011, PLoS ONE 6(5): e19805 Trade-Off between Toxicity and Signal Detection Orchestrated by Frequency- and Density-Dependent Genes. [FBrf0213771] Show all research papers ...