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Gene Dmel\dock

General Information
Symbol	Dmel\dock	Species	D. melanogaster
Name	dreadlocks	Annotation symbol	CG3727
Feature type	protein_coding_gene	FlyBase ID	FBgn0010583
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Nck
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	21E2-21E2	Sequence location	2L:825,964..833,245 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dreadlocks is referred to in FlyBase by the symbol Dmel\dock (CG3727, FBgn0010583). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: insulin receptor binding. There is experimental evidence that it is involved in the biological process: insulin receptor signaling pathway; axon guidance. 34 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; multi-cell-component structure; external compound sense organ; peripheral nervous system; synaptic neuropil subdomain; embryonic/larval neuron; nervous system; adult segment; antennal segment; lobula complex; lamina neuropil; commissure. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Cytoplasmic, NCK; Neutrophil cytosol factor 2 p67phox; SH2 motif; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval Malpighian tubules, larval fat body, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1624864_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of dock. Gene sequence location is 2L:825964..833245.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA00812 BKN22581 Unknown in situ
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E2-21E2   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21D3-21D4   (determined by in situ hybridisation)   (Spradling et al., 1999) 21D3-21D4   (determined by in situ hybridisation)   (Garrity et al., 1996) 21D3-21D4     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Rao, 1996.5.8)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dock for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dock-RA FBtr0078013  NM_057628   3744   410 dock-RB FBtr0078014  NM_164389   3627   548 dock-RC FBtr0078015  NM_164390   3592   548
Additional Transcript Data & Comments
Reported size (kB)	4.1, 3.7 (northern blot) (Clemens et al., 1996) 3.760 (longest cDNA) (Garrity et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dock-PA   FBpp0077678   45.7   410   8.39     NP_476976   AAF51450 dock-PB   FBpp0077679   60.4   548   8.71     NP_722657   AAF51449 dock-PC   FBpp0077680   60.4   548   8.71     NP_722658   AAN10486
Additional Polypeptide Data & Comments
Reported size (kDa)	410 (aa); 50 (kD observed) (Clemens et al., 1996) 410 (aa); 47 (kD observed) (Garrity et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) SH2 motif (IPR000980) Src homology-3 domain (IPR001452) Cytoplasmic, NCK (IPR017304)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141192   AA263260   AA264429   AA438667   AA439174   AA538960   AA698561   AA941747   AA949156   AA949391   AE014134 AAF51449   AE014134 AAF51450   AE014134 AAN10486   AC004546   AI296165   AI403698   AI455065   AI516652   AQ073286   AQ074101   AW943617   AY119614 AAM50268   BE977306   BF488982   BF499615   BI167711   BI169963   BI170705   BI212603   BI213231   BI213859   BI214086   BI366832   BI369919   BI370541   BI374467   CA805445   CK661186   CK662373   CO178515   CO188549   CO189541   CO262000   CO272408   CO290252   CO301929   CO329023   CO329440   EC051794   EC057096   EC059278   EC074664   EC080235   EC084543   EC087796   EC200023   EC201600   EC204829   EC206771   EC208436   EC216435   EC218600   EC229425   EC232166   EC242248   EC244253   EL871347   G01444   GH941265   GH943583   GH944461   GH946681   GH948161   GH948184   GH949785   GH951008   GH951973   GH953725   GH954238   GH955269   GH956838   GH958351   GH960066   GH960559   GH965287   GH969525   GH969699   GH972910   GH980580   GH982410   GH984192   U57816 AAB05596   Z50295
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24218 Q8IPW2 Q9VPU1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage & adult stage     (Clemens et al., 1996) embryonic stage 14   embryonic brain   (Clemens et al., 1996) ventral nerve cord   (Clemens et al., 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & pupal stage & adult stage     (Clemens et al., 1996)
Additional Descriptive Data
	dock transcripts are detected at high levels in embryonic, pupal and adult stages. (Clemens et al., 1996) dock transcripts are detected in the brain and ventral nerve cord of stage 14 embryos. Ptp61F and dock transcripts are expressed in a similar pattern throughout development, with high levels in embryonic, pupal and adult stages. (Clemens et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   medulla neuropil   (Garrity et al., 1996) neuron   • growth cone of axon (Garrity et al., 1996) lamina neuropil   (Garrity et al., 1996) eye-antennal disc   (Garrity et al., 1996)
Additional Descriptive Data
	dock protein is expressed in receptor cells and localizes to receptor cell growth cones. It is also observed in the lamina and medulla neuropil. (Garrity et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010583    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010583 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010583 expression level Developmental Stage   Expression Level embryo 00-02hr    2780 embryo 02-04hr    3590 embryo 04-06hr    3872 embryo 06-08hr    2995 embryo 08-10hr    2914 embryo 10-12hr    2920 embryo 12-14hr    3665 embryo 14-16hr    3295 embryo 16-18hr    2489 embryo 18-20hr    1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    1716 white prepupae new    1770 white prepupae 12hr    2247 white prepupae 24hr    2891 pupae 2d postWPP    3319 pupae 3d postWPP    1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day    1593 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2780) embryo 02-04hr  (3590) embryo 04-06hr  (3872) embryo 06-08hr  (2995) embryo 08-10hr  (2914) embryo 10-12hr  (2920) embryo 12-14hr  (3665) embryo 14-16hr  (3295) embryo 16-18hr  (2489) embryo 18-20hr  (1653) embryo 20-22hr  (1266) embryo 22-24hr  (1352) larva L1  (1341) larva L2  (907) larva L3 12hr old  (624) larva L3 puffstage 1-2  (554) larva L3 puffstage 3-6  (1201) larva L3 puffstage 7-9  (1716) white prepupae new  (1770) white prepupae 12hr  (2247) white prepupae 24hr  (2891) pupae 2d postWPP  (3319) pupae 3d postWPP  (1417) pupae 4d postWPP  (1011) adult male 01day  (1037) adult male 05day  (1369) adult male 30day  (1305) adult female 01day  (1044) adult female 05day  (1593) adult female 30day  (1565) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2780) embryo 02-04hr  (3590) embryo 04-06hr  (3872) embryo 06-08hr  (2995) embryo 08-10hr  (2914) embryo 10-12hr  (2920) embryo 12-14hr  (3665) embryo 14-16hr  (3295) embryo 16-18hr  (2489) embryo 18-20hr  (1653) embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9  (1716) white prepupae new  (1770) white prepupae 12hr  (2247) white prepupae 24hr  (2891) pupae 2d postWPP  (3319) pupae 3d postWPP  1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day  (1593) adult female 30day  (1565) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2780 embryo 02-04hr    3590 embryo 04-06hr    3872 embryo 06-08hr    2995 embryo 08-10hr    2914 embryo 10-12hr    2920 embryo 12-14hr    3665 embryo 14-16hr    3295 embryo 16-18hr    2489 embryo 18-20hr    1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    1716 white prepupae new    1770 white prepupae 12hr    2247 white prepupae 24hr    2891 pupae 2d postWPP    3319 pupae 3d postWPP    1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day    1593 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2780 embryo 02-04hr    3590 embryo 04-06hr    3872 embryo 06-08hr    2995 embryo 08-10hr    2914 embryo 10-12hr    2920 embryo 12-14hr    3665 embryo 14-16hr    3295 embryo 16-18hr    2489 embryo 18-20hr    1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    1716 white prepupae new    1770 white prepupae 12hr    2247 white prepupae 24hr    2891 pupae 2d postWPP    3319 pupae 3d postWPP    1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day    1593 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010583 expression level Developmental Stage   Expression Level embryo 00-02hr    2780 embryo 02-04hr    3590 embryo 04-06hr    3872 embryo 06-08hr    2995 embryo 08-10hr    2914 embryo 10-12hr    2920 embryo 12-14hr    3665 embryo 14-16hr    3295 embryo 16-18hr    2489 embryo 18-20hr    1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    1716 white prepupae new    1770 white prepupae 12hr    2247 white prepupae 24hr    2891 pupae 2d postWPP    3319 pupae 3d postWPP    1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day    1593 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2780) embryo 02-04hr  (3590) embryo 04-06hr  (3872) embryo 06-08hr  (2995) embryo 08-10hr  (2914) embryo 10-12hr  (2920) embryo 12-14hr  (3665) embryo 14-16hr  (3295) embryo 16-18hr  (2489) embryo 18-20hr  (1653) embryo 20-22hr  (1266) embryo 22-24hr  (1352) larva L1  (1341) larva L2  (907) larva L3 12hr old  (624) larva L3 puffstage 1-2  (554) larva L3 puffstage 3-6  (1201) larva L3 puffstage 7-9  (1716) white prepupae new  (1770) white prepupae 12hr  (2247) white prepupae 24hr  (2891) pupae 2d postWPP  (3319) pupae 3d postWPP  (1417) pupae 4d postWPP  (1011) adult male 01day  (1037) adult male 05day  (1369) adult male 30day  (1305) adult female 01day  (1044) adult female 05day  (1593) adult female 30day  (1565) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2780) embryo 02-04hr  (3590) embryo 04-06hr  (3872) embryo 06-08hr  (2995) embryo 08-10hr  (2914) embryo 10-12hr  (2920) embryo 12-14hr  (3665) embryo 14-16hr  (3295) embryo 16-18hr  (2489) embryo 18-20hr  1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9  1716 white prepupae new  1770 white prepupae 12hr  2247 white prepupae 24hr  (2891) pupae 2d postWPP  (3319) pupae 3d postWPP  1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day  1593 adult female 30day  1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2780 embryo 02-04hr    3590 embryo 04-06hr    3872 embryo 06-08hr    2995 embryo 08-10hr    2914 embryo 10-12hr    2920 embryo 12-14hr    3665 embryo 14-16hr    3295 embryo 16-18hr    2489 embryo 18-20hr    1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    1716 white prepupae new    1770 white prepupae 12hr    2247 white prepupae 24hr    2891 pupae 2d postWPP    3319 pupae 3d postWPP    1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day    1593 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2780 embryo 02-04hr    3590 embryo 04-06hr    3872 embryo 06-08hr    2995 embryo 08-10hr    2914 embryo 10-12hr    2920 embryo 12-14hr    3665 embryo 14-16hr    3295 embryo 16-18hr    2489 embryo 18-20hr    1653 embryo 20-22hr    1266 embryo 22-24hr    1352 larva L1    1341 larva L2    907 larva L3 12hr old    624 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1201 larva L3 puffstage 7-9    1716 white prepupae new    1770 white prepupae 12hr    2247 white prepupae 24hr    2891 pupae 2d postWPP    3319 pupae 3d postWPP    1417 pupae 4d postWPP    1011 adult male 01day    1037 adult male 05day    1369 adult male 30day    1305 adult female 01day    1044 adult female 05day    1593 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010583    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010583 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval Malpighian tubules, larval fat body, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010583 expression level Tissue   Expression Level Larval Central Nervous System    756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (756) Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010583 expression level Tissue   Expression Level Larval Central Nervous System    756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    756 Larval Midgut    62.5 Larval Hindgut    84.9 Larval Malpighian Tubules    127.9 Larval Fat Body    185.8 Larval Salivary Gland    73.9 Larval Trachea    103.425 Larval Carcass    93.125 Adult Head    123 Adult Eye    134.15 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    345.8 Adult Crop    66 Adult Midgut    46.7 Adult Hindgut    58.4 Adult Malpighian Tubules    57 Adult Fat Body    53.6 Adult Salivary Gland    66.9 Adult Heart    47.825 Adult VirginFemale Spermatheca    50.5 Adult InseminatedFemale Spermatheca    45 Adult Ovary    75.5 Adult Testis    29.7 Adult Male Accessory Gland    62.5 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    123   NA  Eye    134.15   NA  Brain    384.3   756  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    345.8   NA  Crop    66   62.5  Midgut    46.7   84.9  Hindgut    58.4   127.9  Malpighian Tubules    57   185.8  Fat Body    53.6   73.9  Salivary Gland    66.9   NA  Heart    47.825   103.425  Trachea    NA   NA  VirginFemale Spermatheca    50.5   NA  InseminatedFemale Spermatheca    45   NA  Ovary    75.5   NA  Testis    29.7   NA  Male Accessory Gland    62.5   93.125  Carcass    46.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010583 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3727-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dock Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect | recessive dock04723 dock13421 lethal | pupal stage | recessive dock3 dock04723 dock13421 lethal | recessive dock04723 dockk13421 dockk16610 viable, with Scer\GAL4pnr-MD237 dockGD4034 Other Phenotypes Allele neuroanatomy defective dock04723 dock13421 neuroanatomy defective | cell non-autonomous | somatic clone dock04723 neuroanatomy defective | embryonic stage (with dock3) dock13421 neuroanatomy defective | embryonic stage (with dock13421) dock3 neuroanatomy defective | embryonic stage | recessive dock3 dock04723 dock13421 neuroanatomy defective | pupal stage dock04723 neuroanatomy defective | somatic clone dock04723 uncoordinated | recessive dock3 dock04723 dock13421 wild-type dockGMR.PG dockhs.PG Phenotype manifest in Allele adult antennal nerve | P-stage dock04723 antennal lobe dock04723 antennal lobe & neuropil dock04723 antennal lobe | cell non-autonomous | somatic clone dock04723 antennal lobe glomerulus | P-stage | ectopic dock04723 antennal lobe glomerulus DM2 dock04723 antennal lobe glomerulus DM3 dock04723 Bolwig nerve dock04723 dock3 Bolwig nerve (with Df(2R)EW60) dock3 Bolwig nerve (with dock04723) dock13421 Bolwig nerve (with dock13421) dock04723 embryonic/larval optic lobe dock13421 embryonic/larval optic lobe | somatic clone dock04723 embryonic/larval optic stalk dock04723 embryonic/larval somatic muscle dock13421 dock3 eye photoreceptor cell & growth cone dock04723 glial cell & antennal lobe dock04723 lamina dock04723 dockunspecified lamina anlage dock13421 lamina neuropil dock13421 lamina plexus dock04723 larval inner optic anlage dock04723 larval outer optic anlage dock04723 lobula dock04723 longitudinal connective dock04723 dock13421 dock3 longitudinal connective | maternal effect dock13421 medulla dock04723 dockunspecified medulla | somatic clone dock04723 medulla anlage dock13421 MP1 neuron dock04723 neuron & antennal lobe dock04723 neuron | somatic clone dock04723 pCC neuron dock04723 photoreceptor & axon dock04723 photoreceptor & axon | somatic clone dock04723 photoreceptor cell & axon dock04723 dock13421 dock3 dockunspecified photoreceptor cell & axon (with dock4) dock04723 photoreceptor cell & axon (with dock04723) dock4 photoreceptor cell & axon | somatic clone dockunspecified photoreceptor cell | somatic clone dock04723 photoreceptor cell R1 dock04723 photoreceptor cell R1 & axon dock04723 photoreceptor cell R2 dock04723 photoreceptor cell R2 & axon dock04723 photoreceptor cell R3 dock04723 photoreceptor cell R3 & axon dock04723 photoreceptor cell R4 dock04723 photoreceptor cell R4 & axon dock04723 photoreceptor cell R5 dock04723 photoreceptor cell R5 & axon dock04723 photoreceptor cell R6 dock04723 photoreceptor cell R6 & axon dock04723 photoreceptor cell R7 & axon dock04723 photoreceptor cell R7 & axon | somatic clone dock04723 RP3 neuron & synapse dock04723 dock13421 dock3 ventral nerve cord commissure dock13421 VUM neuron dock13421
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of dock Class Mutagen Stocks Known lesion dock04723 amorphic allele - genetic evidence P-element activity 1 Yes dock5-HA-1332 1 -- dockd09846 1 -- dockk13421 P-element activity 1 -- dock13421 amorphic allele - genetic evidence P-element activity 0 Yes dock3 amorphic allele - genetic evidence Delta2-3 0 Yes dock4 0 Yes dockCB-6869-3 0 -- dockD333 ethyl methanesulfonate 0 -- dockEP1242 P-element activity 0 -- dockHP26308 0 -- dockk16610 P-element activity 0 -- dockunspecified 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dock Class Mutagen Stocks Known lesion dockGD4034 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dockJF02810 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dockKK102500 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dockAct5C.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dockdsRNA.cCa in vitro construct - RNAi 0 Yes dockdsRNA.cKa in vitro construct - RNAi 0 Yes dockdsRNA.cWa in vitro construct - RNAi 0 Yes dockGMR.PG in vitro construct - regulatory fusion 0 Yes dockhs.PG in vitro construct - regulatory fusion 0 Yes dockR336Q.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes dockW151K.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW225K.R336Q.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW225K.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW48K.R336Q.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW48K.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW48K.W151K.W225K.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW48K.W225K.R336Q.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW48K.W225K.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockW48K.W225K.ΔSH2.Scer\UAS in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes dockΔSH2.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ast1 (BDGP Project Members, 1994-1999) Df(2L)ast2 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Garrity et al., 1996) Df(2L)ast10 (BDGP Project Members, 1994-1999) Df(2L)Exel7005 (Ryder, 2004.4.26) Df(2L)S2 (BDGP Project Members, 1994-1999) In(2L)ast-1 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4034} NA P{KK102500} NA P{TRiP.JF02810} NA P{UAS-dock.R336Q} NA P{UAS-dock.R} NA P{UAS-dock.W48K.R336Q} NA P{UAS-dock.W48K.W151K.W225K} NA P{UAS-dock.W48K.W225K.R336Q} NA P{UAS-dock.W48K.W225K.ΔSH2} NA P{UAS-dock.W48K.W225K} NA P{UAS-dock.W48K} NA P{UAS-dock.W151K} NA P{UAS-dock.W225K.R336Q} NA P{UAS-dock.W225K} NA P{UAS-dock.ΔSH2} NA heat-shock construct P{hs-dock} NA characterization construct P{GMR-dock} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}dockCB-6869-3 NA P{RS5}dock5-HA-1332 NA insertion of enhancer trap P{lacW}dockk13421 No P{lacW}dockk16610 No P{lacW}l(2)SH1112SH1112 No P{PZ}dock04723 No P{PZ}dock13421 No insertion of mobile activating element P{EP}CG3862EP1242 NA P{EPg}dockHP26308 NA P{XP}dockd09846 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
insulin receptor binding inferred from physical interaction with InR (Song et al., 2003)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Dscam (Schmucker et al., 2000) inferred from mutant phenotype (Stevens and Jacobs, 2002) insulin receptor signaling pathway inferred from physical interaction with InR (Song et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
SH3/SH2 adaptor activity inferred from sequence or structural similarity with EMBL:U85781 (FlyBase, 1992-) inferred from sequence or structural similarity with human NCK1 (Garrity et al., 1996) non-traceable author statement (Rao, 1996.5.8) traceable author statement (Song et al., 2003)
Biological Process
CV term Evidence References
axon guidance traceable author statement (Newsome et al., 2000, Song et al., 2003, Hallem and Carlson, 2004) axonogenesis traceable author statement (Bateman and Van Vactor, 2001, Dickson, 2003)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Dickson, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dock allele Gene References dock3 Dscam (Schmucker et al., 2000) dock4 trio (Newsome et al., 2000) dock04723 btl::Egfr (Schnorr et al., 2001) InR (Song et al., 2003) msn (Ruan et al., 1999, Su et al., 2000) Ras85D (Schnorr et al., 2001) trio (Newsome et al., 2000) dock13421 Hem (Hummel et al., 2000) InR (Song et al., 2003) msn (Ruan et al., 1999) dockScer\UAS.cRa msn (Ruan et al., 1999) dockunspecified Pak (Hing et al., 1999) dockW48K.Scer\UAS msn (Ruan et al., 1999) dockW225K.Scer\UAS msn (Ruan et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59516 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010583 DroID - A comprehensive database of gene and protein interactions. • FBgn0010583 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33262
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15078 Dere\GG24749 Dgri\GH11246 Dmoj\GI21852 Dper\GL19500 Dpse\GA17645 Dsec\GM16771 Dsim\GD23050 Dvir\GJ17798 Dwil\GK24636 Dyak\GE17132
Curated drosophilid orthologs	Dpse\GA17645
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013539-PA Aedes aegypti (mosquito) AGAP010135-PA Anopheles gambiae (mosquito) XP_624281.1 Apis mellifera (honey bee) XP_001947020.1 Acyrthosiphon pisum (pea aphid) BGIBMGA003789-PA Bombyx mori (silk worm) ENSBTAP00000024518 Bos taurus (bovine) CN21649 Caenorhabditis brenneri (small nematode) CBP03596 Caenorhabditis briggsae (nematode) CE31270 Caenorhabditis elegans (worm) ENSCAFP00000011072 Canis familiaris (dog) ENSCINP00000016260 Ciona intestinalis (sea squirt) JA15421 Caenorhabditis japonica (nematode) CPIJ003100 Culex pipens (mosquito) ENSCPOP00000004302 Cavia porcellus (guinea pig) RP06155 Caenorhabditis remanei (nematode) ENSCSAVP00000001230 Ciona savignyi (sedentary tunicate) DDB0190636 Dictyostelium discoideum (amoeba) ENSDARP00000063647 Danio rerio (zebra fish) ENSECAP00000016849 Equus caballus (horse) ENSGACP00000004728 Gymnopilus aculeatus (mushroom) ENSGALP00000027070 Gallus gallus (chicken) ENSP00000288986 Homo sapiens (human) ISCW023626-PA Ixodes scapularis (deer tick) ENSMODP00000023122 Monodelphis domestica (gray opossum) ENSMMUP00000009696 Macaca mulatta (rhesus monkey) ENSMUSP00000112221 Mus musculus (house mouse) ENSOANP00000000957 Ornithorynchus anatinus (platypus) ENSORLP00000015651 Oryzias latipes (japanese killifish) PHUM011182-PA Pediculus humanus (human body louse) ENSPPYP00000015810 Pongo pygmaeus (orangutan) ENSPTRP00000026594 Pan troglodytes (chimpanzee) ENSRNOP00000023029 Rattus norvegicus (norway rat) XP_784072.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969702.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015727 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000045454 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000053525 Xenopus tropicalis (frog) YALI0F27643g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13762 LH13203 ISCW023626 FBgn0234613 FBgn0226596 FBgn0204966 FBgn0194441 FBgn0171684 JGI_V11_306711 FBgn0077656 FBgn0157099 FBgn0144581 FBgn0118726 FBgn0116880 FBgn0092103 CPIJ003100 BGIBMGA003789 ACYPI002759 GB12942 AGAP010135 AAEL013539 PB19753 PHUM584020 GLEAN_13803
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	27728 y1 v1; P{TRiP.JF02810}attP2 11385 P{PZ}dock04723 cn1/CyO; ry506 10444 y1 w67c23; P{lacW}dockk13421/CyO
Harvard	- P{XP}dockd09846
Kyoto	125197 w1118; P{RS5}dock5-HA-1332
VDRC	v107064 P{KK102500}VIE-260B v37524 w1118; P{GD4034}v37524 v37525 w1118; P{GD4034}v37525
Genomic Clones ( 1 )
	BACR16I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD42588
Other clones	DPiM_LD42588
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14217 AT24664 GH23191 HL04931 LD07244 LD08129 LD12988 LD13661 LD13820 LD18640 LD25925 LD27942 LD28270 LP09994 LP20408 LP22531 RE08155 RE11284 RE12250 RE17720 RE18591 RE19483 RE19792 RE52452 RE56258 RE57204 RE62064
Other clones	bs62b10 CK01351 EC051794 EK040862 EK044508 EK056930 EK073454 EK083542 EK107040 EK182726 EK291855 EK292838 ESG0118b.B21_A11 IP03460 RP004035671 RP004070483 RP004100820 RP004118132 RP004124863 RP004150728 RP004162682 RP004179763 RP004200111 RP004200319 RP004200778 RP004217935 RP004221201 RP004239458 RP004240370 RP004249209 RP004268410 RP004390578 RP004437557 RP004440025 RP004494770 RP004543190 RP004549369
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010583 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33262
Antibody Information
	polyclonal (Clemens et al., 1996)
Other Information
Discoverer
Etymology
	The gene is named "dreadlocks" for the appearance of the receptor cell projection pattern in the mutant. (Garrity et al., 1996)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dock CG3727 (Li, 1999.11)
Source for database merge of
Additional comments	Neuron-specific expression of Hsap\NCK rescues defects in dock mutants. (Rao and Zipursky, 1998)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) dock facilitates synapse formation by the RP3 motoneuron and is required for guidance of some interneuronal axons. dock mediated signalling may be important in remodelling the RP3 growth cone's cytoskelton. (Desai et al., 1999) Loss of zygotic dock function causes a selective delay in synapse formation by the RP3 motoneuron at the cleft between muscles 7 and 6. In late stage 16 mutant embryos these muscles often lack innervation. By the third larval instar muscles have become innervated by RP3. dock mutants also show subtle defects in the CNS longitudinal axon pathway. (Desai et al., 1999) dock can couple signals in either an SH2-dependent or an SH2-independent fashion in photoreceptor growth cones. dock displays different domain requirements in different neurons. (Rao and Zipursky, 1998) Isolated in a yeast two-hybrid system, by screening for Ptp61F-interacting proteins. (Clemens et al., 1996) Mutations in dock disrupt photoreceptor cell axon guidance and targeting. Genetic mosaic analysis and cell-type-specific expression of dock transgenes demonstrate dock is required in receptor cells for proper innervation. (Garrity et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057628 NM_164389 NM_164390 RefSeq (Proteins) • NP_476976 NP_722657 NP_722658 DDBJ / EMBL / GenBank • AAB05596 AAF51449 AAF51450 AAM50268 AAN10486 AC004546 AI516652 AQ073286 AQ074101 AW943617 AY119614 G01444 U57816 Z50295 Entrez Gene - A searchable database of RefSeq genes. • 33262 UniProtKB/TrEMBL • Q8IPW2 Q9VPU1 Q24218
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) SH2 motif (IPR000980) Src homology-3 domain (IPR001452) Cytoplasmic, NCK (IPR017304)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59516 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010583 DroID - A comprehensive database of gene and protein interactions. • FBgn0010583 DRSC - Results from RNAi screens. • FBgn0010583 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010583 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3727-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010583 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33262 InParanoid A subset of ortholog calls from InParanoid. • AAEL013539-PA Aedes aegypti (mosquito) AGAP010135-PA Anopheles gambiae (mosquito) XP_624281.1 Apis mellifera (honey bee) XP_001947020.1 Acyrthosiphon pisum (pea aphid) BGIBMGA003789-PA Bombyx mori (silk worm) ENSBTAP00000024518 Bos taurus (bovine) CN21649 Caenorhabditis brenneri (small nematode) CBP03596 Caenorhabditis briggsae (nematode) CE31270 Caenorhabditis elegans (worm) ENSCAFP00000011072 Canis familiaris (dog) ENSCINP00000016260 Ciona intestinalis (sea squirt) JA15421 Caenorhabditis japonica (nematode) CPIJ003100 Culex pipens (mosquito) ENSCPOP00000004302 Cavia porcellus (guinea pig) RP06155 Caenorhabditis remanei (nematode) ENSCSAVP00000001230 Ciona savignyi (sedentary tunicate) DDB0190636 Dictyostelium discoideum (amoeba) ENSDARP00000063647 Danio rerio (zebra fish) ENSECAP00000016849 Equus caballus (horse) ENSGACP00000004728 Gymnopilus aculeatus (mushroom) ENSGALP00000027070 Gallus gallus (chicken) ENSP00000288986 Homo sapiens (human) ISCW023626-PA Ixodes scapularis (deer tick) ENSMODP00000023122 Monodelphis domestica (gray opossum) ENSMMUP00000009696 Macaca mulatta (rhesus monkey) ENSMUSP00000112221 Mus musculus (house mouse) ENSOANP00000000957 Ornithorynchus anatinus (platypus) ENSORLP00000015651 Oryzias latipes (japanese killifish) PHUM011182-PA Pediculus humanus (human body louse) ENSPPYP00000015810 Pongo pygmaeus (orangutan) ENSPTRP00000026594 Pan troglodytes (chimpanzee) ENSRNOP00000023029 Rattus norvegicus (norway rat) XP_784072.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969702.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015727 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000045454 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000053525 Xenopus tropicalis (frog) YALI0F27643g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/dreadlk1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33262 modMine - Data generated by the modENCODE project. • FBgn0010583 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13762 LH13203 ISCW023626 FBgn0234613 FBgn0226596 FBgn0204966 FBgn0194441 FBgn0171684 JGI_V11_306711 FBgn0077656 FBgn0157099 FBgn0144581 FBgn0118726 FBgn0116880 FBgn0092103 CPIJ003100 BGIBMGA003789 ACYPI002759 GB12942 AGAP010135 AAEL013539 PB19753 PHUM584020 GLEAN_13803
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG3727 (Rogers et al., 2003, Keleman et al., 2009.8.5, Perkins et al., 2009, Berger et al., 2008) dck (Paricio et al., 1999) Dm0447 (Teeter et al., 2000) doc (Garcia-Alonso, 1999) dock (MacMullin and Jacobs, 2006, Sterling et al., 2007, Hofmann et al., 2004, Baer et al., 2007, Shcherbata et al., 2007, Yang and Bashaw, 2006, Berger et al., 2008, Magalhaes et al., 2007, Goto et al., 2011) Dock (Albin and Davis, 2004, Baas and Luo, 2001, Zhan et al., 2001, Duchek et al., 2001, Luo, 2000, Rao, 1996.5.8, Stoker and Dutta, 1998, Su et al., 1998, Clemens et al., 1996, Shcherbata et al., 2007, Erfurth and Schmucker, 2008, Pramatarova et al., 2003, Rohrbough et al., 2007) l(2)04723   Nck (Rogers et al., 2003, Rogers et al., 2003, Hofmann et al., 2004)
Name Synonym	dreadlocks (Yang and Bashaw, 2006) Dreadlocks (Rogers et al., 2003)
Secondary FlyBase IDs
	FBgn0041141
References ( 120 )
Generate a list of	All references relating to this gene ( 120 )
List References by type	Research paper  ( 47 ) Supplementary material  ( 8 ) Review  ( 32 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 3 ) Conference report  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Fabre et al., 2010, Development 137(17): 2885--2894 Mechanosensilla in the adult abdomen of Drosophila: engrailed and slit help to corral the peripheral sensory axons into segmental bundles. [FBrf0211534] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...