• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\l(2)06225

General Information
Symbol	Dmel\l(2)06225	Species	D. melanogaster
Name	lethal (2) 06225	Annotation symbol	CG6105
Feature type	protein_coding_gene	FlyBase ID	FBgn0010612
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32C1-32C1	Sequence location	2L:10,975,522..10,976,399 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) 06225 is referred to in FlyBase by the symbol Dmel\l(2)06225 (CG6105, FBgn0010612). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: hydrogen-exporting ATPase activity, phosphorylative mechanism. Based on sequence similarity, it is predicted to be involved in the biological process: proton transport. 5 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: ATPase, F0 complex, subunit G, mitochondrial; Mitochondrial ATP synthase subunit g, animal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629647_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of l(2)06225. Gene sequence location is 2L:10975522..10976399.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32C1-32C1   Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32C4-32C5   (determined by in situ hybridisation)   (Spradling et al., 1999) 32C4-32C5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)06225 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)06225-RA FBtr0080167  NM_143778   497   99 l(2)06225-RB FBtr0110872  NM_001042888   477   99 l(2)06225-RD FBtr0305994  NM_001042889   733   99
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)06225-PA   FBpp0079756   10.9   99   10.28     NP_652035   AAF53041 l(2)06225-PB   FBpp0110172   10.9   99   10.28     NP_001036353   ABI31307 l(2)06225-PD   FBpp0297136   10.9   99   10.28     NP_001036354   ABI31308
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, F0 complex, subunit G, mitochondrial (IPR006808) Mitochondrial ATP synthase subunit g, animal (IPR016702) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06105
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140821   AA140822   AE014134 AAF53041   AE014134 ABI31307   AE014134 ABI31308   AF083297   AI110042   AI134581   AI292794   AI294902   AI945176   AI945370   AI945695   AI947132   AQ025646   AY070693 AAL48164   AY070836   AY071165 AAL48787   AY232044   BE975153   BF496987   BI214747   BI216236   BI354098   BI354956   BI357603   BI361329   BI368093   BI370295   BI374266   BI482422   BI565336   BI565774   BI566361   BI566547   BI567008   BI567419   BI567597   BI568075   BI568535   BI570292   BI571309   BI571365   BI571957   BI572103   BI572141   BI572142   BI572817   BI574776   BI574964   BI575093   BI575209   BI575544   BI575832   BI576004   BI581287   BI581808   BI581925   BI581935   BI581982   BI582111   BI582197   BI582893   BI585056   BI585060   BI585692   BI585703   BI586761   BI587639   BI588437   BI589979   BI593012   BI604660   BI605151   BI606321   BI606351   BI606473   BI607645   BI609022   BI610420   BI610574   BI613542   BI617052   BI617283   BI617493   BI617614   BI618867   BI622678   BI622812   BI624993   BI625717   BI627464   BI627739   BI629627   BI630088   BI630978   BI631238   BI634227   BI634492   BI634515   BP545387   BP545388   BP546173   BP552267   BP552268   BP552785   BP552786   BX016133   BX032746   BX038171   CO155665   CO185491   CO189199   CO266557   CO272390   CO296301   CO296631   CO336946   DN154125   DQ440256   EC085197   EC091021   EC206837   EC223437   EC244934   EC247436   EC267518   EV576974   EV577720   EV578458   EV580249   EV585058   EV589736   EV592426   EV594266   EV594387   EV595586   EV598472   EV599380   GH748852   GH751438   GH752335   GH752854   GH753627   GH757622   GH759478   GH761253   GH761374   GH775543   GH776871   GH777311   GH780219   GH780246   GH783635   GH785298   GH786847   GH787475   GH788967   GH793013   GH793382   GH797381   GH798089   GH799088   GH799773   GH802480   GH804534   GH807568   GH807842   GH808687   GH809107   GH810210   GH812365   GH813887   GH815121   GH816642   GH817224   GH817240   GH817558   GH819259   GH820180   GH821368   GH822140   GH822256   GH822353   GH822633   GH823729   GH824926   GH826576   GH826953   GH827693   GH828265   GH828974   GH829838   GH833756   GH836166   GH836551   GH842347   GH842628   GH842706   GH843823   GH845772   GH846025   GH847727   GH848225   GH848480   GH849049   GH853435   GH854098   GH854719   GH854819   GH858773   GH860895   GH862668   GH863165   GH863687   GH864425   GH866359   GH868770   GH870350   GH871334   GH871713   GH871866   GH873852   GH874178   GH874307   GH874433   GH874490   GH875176   GH876367   GH876708   GH877482   GH878687   GH883756   GH885243   GH885538   GH886329   GH891073   GH893162   GH897161   GH897246   GH899302   GH902665   GH904250   GH904978   GH905956   GH908957   GH911116   GH911716   GH912594   GH912672   GH913347   GH914844   GH915052   GH918761   GH919714   GH919737   GH923017   GH923059   GH924511   GH926248   GH928367   GH931859   GH932102   GH933651   GH935215   GH936892   GH937917   GH939129   GH939171   GH939288   GH939302   GH939636   GH939943   GH940462   GH940477   GH940480   GH940663   GH940798
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VKM3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic main segment of Malpighian tubule   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1653.8 Larval Midgut    2593.7 Larval Hindgut    3072.4 Larval Malpighian Tubules    1884.2 Larval Fat Body    761.1 Larval Salivary Gland    3168.5 Larval Trachea    2347.375 Larval Carcass    2802 Adult Head    2717.6 Adult Eye    3566.1 Adult Brain    2081.1 Adult Thoracic-Abdominal Ganglion    2994.3 Adult Crop    2415 Adult Midgut    2490.1 Adult Hindgut    3508.4 Adult Malpighian Tubules    2501.9 Adult Fat Body    3396.6 Adult Salivary Gland    4042.2 Adult Heart    3790.425 Adult VirginFemale Spermatheca    2055.9 Adult InseminatedFemale Spermatheca    1997.2 Adult Ovary    1425.4 Adult Testis    724.9 Adult Male Accessory Gland    2196.7 Adult Carcass    4958.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1653.8) Larval Midgut  (2593.7) Larval Hindgut  (3072.4) Larval Malpighian Tubules  (1884.2) Larval Fat Body  (761.1) Larval Salivary Gland  (3168.5) Larval Trachea  (2347.375) Larval Carcass  (2802) Adult Head  (2717.6) Adult Eye  (3566.1) Adult Brain  (2081.1) Adult Thoracic-Abdominal Ganglion  (2994.3) Adult Crop  (2415) Adult Midgut  (2490.1) Adult Hindgut  (3508.4) Adult Malpighian Tubules  (2501.9) Adult Fat Body  (3396.6) Adult Salivary Gland  (4042.2) Adult Heart  (3790.425) Adult VirginFemale Spermatheca  (2055.9) Adult InseminatedFemale Spermatheca  (1997.2) Adult Ovary  (1425.4) Adult Testis  (724.9) Adult Male Accessory Gland  (2196.7) Adult Carcass  (4958.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1653.8) Larval Midgut  (2593.7) Larval Hindgut  (3072.4) Larval Malpighian Tubules  (1884.2) Larval Fat Body    761.1 Larval Salivary Gland  (3168.5) Larval Trachea  (2347.375) Larval Carcass  (2802) Adult Head  (2717.6) Adult Eye  (3566.1) Adult Brain  (2081.1) Adult Thoracic-Abdominal Ganglion  (2994.3) Adult Crop  (2415) Adult Midgut  (2490.1) Adult Hindgut  (3508.4) Adult Malpighian Tubules  (2501.9) Adult Fat Body  (3396.6) Adult Salivary Gland  (4042.2) Adult Heart  (3790.425) Adult VirginFemale Spermatheca  (2055.9) Adult InseminatedFemale Spermatheca  (1997.2) Adult Ovary  (1425.4) Adult Testis    724.9 Adult Male Accessory Gland  (2196.7) Adult Carcass  (4958.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1653.8 Larval Midgut    2593.7 Larval Hindgut    3072.4 Larval Malpighian Tubules    1884.2 Larval Fat Body    761.1 Larval Salivary Gland    3168.5 Larval Trachea    2347.375 Larval Carcass    2802 Adult Head    2717.6 Adult Eye    3566.1 Adult Brain    2081.1 Adult Thoracic-Abdominal Ganglion    2994.3 Adult Crop    2415 Adult Midgut    2490.1 Adult Hindgut    3508.4 Adult Malpighian Tubules    2501.9 Adult Fat Body    3396.6 Adult Salivary Gland    4042.2 Adult Heart    3790.425 Adult VirginFemale Spermatheca    2055.9 Adult InseminatedFemale Spermatheca    1997.2 Adult Ovary    1425.4 Adult Testis    724.9 Adult Male Accessory Gland    2196.7 Adult Carcass    4958.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1653.8 Larval Midgut    2593.7 Larval Hindgut    3072.4 Larval Malpighian Tubules    1884.2 Larval Fat Body    761.1 Larval Salivary Gland    3168.5 Larval Trachea    2347.375 Larval Carcass    2802 Adult Head    2717.6 Adult Eye    3566.1 Adult Brain    2081.1 Adult Thoracic-Abdominal Ganglion    2994.3 Adult Crop    2415 Adult Midgut    2490.1 Adult Hindgut    3508.4 Adult Malpighian Tubules    2501.9 Adult Fat Body    3396.6 Adult Salivary Gland    4042.2 Adult Heart    3790.425 Adult VirginFemale Spermatheca    2055.9 Adult InseminatedFemale Spermatheca    1997.2 Adult Ovary    1425.4 Adult Testis    724.9 Adult Male Accessory Gland    2196.7 Adult Carcass    4958.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1653.8) Larval Midgut  (2593.7) Larval Hindgut  (3072.4) Larval Malpighian Tubules  (1884.2) Larval Fat Body  761.1 Larval Salivary Gland  (3168.5) Larval Trachea  (2347.375) Larval Carcass  (2802) Adult Head  (2717.6) Adult Eye  (3566.1) Adult Brain  (2081.1) Adult Thoracic-Abdominal Ganglion  (2994.3) Adult Crop  (2415) Adult Midgut  (2490.1) Adult Hindgut  (3508.4) Adult Malpighian Tubules  (2501.9) Adult Fat Body  (3396.6) Adult Salivary Gland  (4042.2) Adult Heart  (3790.425) Adult VirginFemale Spermatheca  (2055.9) Adult InseminatedFemale Spermatheca  (1997.2) Adult Ovary  (1425.4) Adult Testis  724.9 Adult Male Accessory Gland  (2196.7) Adult Carcass  (4958.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1653.8 Larval Midgut  (2593.7) Larval Hindgut  (3072.4) Larval Malpighian Tubules  (1884.2) Larval Fat Body    761.1 Larval Salivary Gland  (3168.5) Larval Trachea  (2347.375) Larval Carcass  (2802) Adult Head  (2717.6) Adult Eye  (3566.1) Adult Brain  (2081.1) Adult Thoracic-Abdominal Ganglion  (2994.3) Adult Crop  (2415) Adult Midgut  (2490.1) Adult Hindgut  (3508.4) Adult Malpighian Tubules  (2501.9) Adult Fat Body  (3396.6) Adult Salivary Gland  (4042.2) Adult Heart  (3790.425) Adult VirginFemale Spermatheca  (2055.9) Adult InseminatedFemale Spermatheca  (1997.2) Adult Ovary  1425.4 Adult Testis    724.9 Adult Male Accessory Gland  (2196.7) Adult Carcass  (4958.7) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1653.8 Larval Midgut    2593.7 Larval Hindgut    3072.4 Larval Malpighian Tubules    1884.2 Larval Fat Body    761.1 Larval Salivary Gland    3168.5 Larval Trachea    2347.375 Larval Carcass    2802 Adult Head    2717.6 Adult Eye    3566.1 Adult Brain    2081.1 Adult Thoracic-Abdominal Ganglion    2994.3 Adult Crop    2415 Adult Midgut    2490.1 Adult Hindgut    3508.4 Adult Malpighian Tubules    2501.9 Adult Fat Body    3396.6 Adult Salivary Gland    4042.2 Adult Heart    3790.425 Adult VirginFemale Spermatheca    2055.9 Adult InseminatedFemale Spermatheca    1997.2 Adult Ovary    1425.4 Adult Testis    724.9 Adult Male Accessory Gland    2196.7 Adult Carcass    4958.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2717.6   NA  Eye    3566.1   NA  Brain    2081.1   1653.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2994.3   NA  Crop    2415   2593.7  Midgut    2490.1   3072.4  Hindgut    3508.4   1884.2  Malpighian Tubules    2501.9   761.1  Fat Body    3396.6   3168.5  Salivary Gland    4042.2   NA  Heart    3790.425   2347.375  Trachea    NA   NA  VirginFemale Spermatheca    2055.9   NA  InseminatedFemale Spermatheca    1997.2   NA  Ovary    1425.4   NA  Testis    724.9   NA  Male Accessory Gland    2196.7   2802  Carcass    4958.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    108 central nervous system, larvae L3    69 central nervous system, pupae P8    77 head, virgin 1-day female    175 head, virgin 4-day female    102 head, virgin 20-day female    124 head, mated 1-day female    115 head, mated 4-day female    82 head, mated 20-day female    94 head, mated 1-day male    202 head, mated 4-day male    118 head, mated 20-day male    136 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    162 digestive system, 4-day adult    92 digestive system, 20-day adult    98 fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8    59 carcass, larvae L3 wandering    56 carcass, 1-day adult    359 carcass, 4-day adult    192 carcass, 20-day adult    152 ovary, virgin 4-day female    79 ovary, mated 4-day female    61 testis, mated 4-day male    85 accessory gland, mated 4-day male    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (108) central nervous system, larvae L3  (69) central nervous system, pupae P8  (77) head, virgin 1-day female  (175) head, virgin 4-day female  (102) head, virgin 20-day female  (124) head, mated 1-day female  (115) head, mated 4-day female  (82) head, mated 20-day female  (94) head, mated 1-day male  (202) head, mated 4-day male  (118) head, mated 20-day male  (136) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  (53) digestive system, 1-day adult  (162) digestive system, 4-day adult  (92) digestive system, 20-day adult  (98) fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8  (59) carcass, larvae L3 wandering  (56) carcass, 1-day adult  (359) carcass, 4-day adult  (192) carcass, 20-day adult  (152) ovary, virgin 4-day female  (79) ovary, mated 4-day female  (61) testis, mated 4-day male  (85) accessory gland, mated 4-day male  (84) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (108) central nervous system, larvae L3    69 central nervous system, pupae P8    77 head, virgin 1-day female  (175) head, virgin 4-day female  102 head, virgin 20-day female  (124) head, mated 1-day female  (115) head, mated 4-day female    82 head, mated 20-day female    94 head, mated 1-day male  (202) head, mated 4-day male  (118) head, mated 20-day male  (136) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    53 digestive system, 1-day adult  (162) digestive system, 4-day adult    92 digestive system, 20-day adult    98 fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8    59 carcass, larvae L3 wandering    56 carcass, 1-day adult  (359) carcass, 4-day adult  (192) carcass, 20-day adult  (152) ovary, virgin 4-day female    79 ovary, mated 4-day female    61 testis, mated 4-day male    85 accessory gland, mated 4-day male    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    108 central nervous system, larvae L3    69 central nervous system, pupae P8    77 head, virgin 1-day female    175 head, virgin 4-day female    102 head, virgin 20-day female    124 head, mated 1-day female    115 head, mated 4-day female    82 head, mated 20-day female    94 head, mated 1-day male    202 head, mated 4-day male    118 head, mated 20-day male    136 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    162 digestive system, 4-day adult    92 digestive system, 20-day adult    98 fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8    59 carcass, larvae L3 wandering    56 carcass, 1-day adult    359 carcass, 4-day adult    192 carcass, 20-day adult    152 ovary, virgin 4-day female    79 ovary, mated 4-day female    61 testis, mated 4-day male    85 accessory gland, mated 4-day male    84 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    108 central nervous system, larvae L3    69 central nervous system, pupae P8    77 head, virgin 1-day female    175 head, virgin 4-day female    102 head, virgin 20-day female    124 head, mated 1-day female    115 head, mated 4-day female    82 head, mated 20-day female    94 head, mated 1-day male    202 head, mated 4-day male    118 head, mated 20-day male    136 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    162 digestive system, 4-day adult    92 digestive system, 20-day adult    98 fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8    59 carcass, larvae L3 wandering    56 carcass, 1-day adult    359 carcass, 4-day adult    192 carcass, 20-day adult    152 ovary, virgin 4-day female    79 ovary, mated 4-day female    61 testis, mated 4-day male    85 accessory gland, mated 4-day male    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (108) central nervous system, larvae L3  (69) central nervous system, pupae P8  (77) head, virgin 1-day female  (175) head, virgin 4-day female  (102) head, virgin 20-day female  (124) head, mated 1-day female  (115) head, mated 4-day female  (82) head, mated 20-day female  (94) head, mated 1-day male  (202) head, mated 4-day male  (118) head, mated 20-day male  (136) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  (53) digestive system, 1-day adult  (162) digestive system, 4-day adult  (92) digestive system, 20-day adult  (98) fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8  (59) carcass, larvae L3 wandering  (56) carcass, 1-day adult  (359) carcass, 4-day adult  (192) carcass, 20-day adult  (152) ovary, virgin 4-day female  (79) ovary, mated 4-day female  (61) testis, mated 4-day male  (85) accessory gland, mated 4-day male  (84) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  108 central nervous system, larvae L3    69 central nervous system, pupae P8    77 head, virgin 1-day female  (175) head, virgin 4-day female  102 head, virgin 20-day female  124 head, mated 1-day female  115 head, mated 4-day female    82 head, mated 20-day female    94 head, mated 1-day male  (202) head, mated 4-day male  118 head, mated 20-day male  136 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    53 digestive system, 1-day adult  (162) digestive system, 4-day adult    92 digestive system, 20-day adult    98 fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8    59 carcass, larvae L3 wandering    56 carcass, 1-day adult  (359) carcass, 4-day adult  (192) carcass, 20-day adult  (152) ovary, virgin 4-day female    79 ovary, mated 4-day female    61 testis, mated 4-day male    85 accessory gland, mated 4-day male    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    108 central nervous system, larvae L3    69 central nervous system, pupae P8    77 head, virgin 1-day female    175 head, virgin 4-day female    102 head, virgin 20-day female    124 head, mated 1-day female    115 head, mated 4-day female    82 head, mated 20-day female    94 head, mated 1-day male    202 head, mated 4-day male    118 head, mated 20-day male    136 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    162 digestive system, 4-day adult    92 digestive system, 20-day adult    98 fat body, larvae L3 wandering    25 fat body, white prepupae    25 fat body, pupae P8    59 carcass, larvae L3 wandering    56 carcass, 1-day adult    359 carcass, 4-day adult    192 carcass, 20-day adult    152 ovary, virgin 4-day female    79 ovary, mated 4-day female    61 testis, mated 4-day male    85 accessory gland, mated 4-day male    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    140 embryo 02-04hr    240 embryo 04-06hr    215 embryo 06-08hr    180 embryo 08-10hr    169 embryo 10-12hr    207 embryo 12-14hr    155 embryo 14-16hr    167 embryo 16-18hr    205 embryo 18-20hr    292 embryo 20-22hr    347 embryo 22-24hr    322 larva L1    350 larva L2    418 larva L3 12hr old    367 larva L3 puffstage 1-2    215 larva L3 puffstage 3-6    122 larva L3 puffstage 7-9    116 white prepupae new    106 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    178 pupae 3d postWPP    375 pupae 4d postWPP    498 adult male 01day    529 adult male 05day    422 adult male 30day    187 adult female 01day    411 adult female 05day    223 adult female 30day    176 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (140) embryo 02-04hr  (240) embryo 04-06hr  (215) embryo 06-08hr  (180) embryo 08-10hr  (169) embryo 10-12hr  (207) embryo 12-14hr  (155) embryo 14-16hr  (167) embryo 16-18hr  (205) embryo 18-20hr  (292) embryo 20-22hr  (347) embryo 22-24hr  (322) larva L1  (350) larva L2  (418) larva L3 12hr old  (367) larva L3 puffstage 1-2  (215) larva L3 puffstage 3-6  (122) larva L3 puffstage 7-9  (116) white prepupae new  (106) white prepupae 12hr  (91) white prepupae 24hr  (101) pupae 2d postWPP  (178) pupae 3d postWPP  (375) pupae 4d postWPP  (498) adult male 01day  (529) adult male 05day  (422) adult male 30day  (187) adult female 01day  (411) adult female 05day  (223) adult female 30day  (176) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (140) embryo 02-04hr  (240) embryo 04-06hr  (215) embryo 06-08hr  (180) embryo 08-10hr  (169) embryo 10-12hr  (207) embryo 12-14hr  (155) embryo 14-16hr  (167) embryo 16-18hr  (205) embryo 18-20hr  (292) embryo 20-22hr  (347) embryo 22-24hr  (322) larva L1  (350) larva L2  (418) larva L3 12hr old  (367) larva L3 puffstage 1-2  (215) larva L3 puffstage 3-6  (122) larva L3 puffstage 7-9  (116) white prepupae new  106 white prepupae 12hr    91 white prepupae 24hr  101 pupae 2d postWPP  (178) pupae 3d postWPP  (375) pupae 4d postWPP  (498) adult male 01day  (529) adult male 05day  (422) adult male 30day  (187) adult female 01day  (411) adult female 05day  (223) adult female 30day  (176) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    140 embryo 02-04hr    240 embryo 04-06hr    215 embryo 06-08hr    180 embryo 08-10hr    169 embryo 10-12hr    207 embryo 12-14hr    155 embryo 14-16hr    167 embryo 16-18hr    205 embryo 18-20hr    292 embryo 20-22hr    347 embryo 22-24hr    322 larva L1    350 larva L2    418 larva L3 12hr old    367 larva L3 puffstage 1-2    215 larva L3 puffstage 3-6    122 larva L3 puffstage 7-9    116 white prepupae new    106 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    178 pupae 3d postWPP    375 pupae 4d postWPP    498 adult male 01day    529 adult male 05day    422 adult male 30day    187 adult female 01day    411 adult female 05day    223 adult female 30day    176 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    140 embryo 02-04hr    240 embryo 04-06hr    215 embryo 06-08hr    180 embryo 08-10hr    169 embryo 10-12hr    207 embryo 12-14hr    155 embryo 14-16hr    167 embryo 16-18hr    205 embryo 18-20hr    292 embryo 20-22hr    347 embryo 22-24hr    322 larva L1    350 larva L2    418 larva L3 12hr old    367 larva L3 puffstage 1-2    215 larva L3 puffstage 3-6    122 larva L3 puffstage 7-9    116 white prepupae new    106 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    178 pupae 3d postWPP    375 pupae 4d postWPP    498 adult male 01day    529 adult male 05day    422 adult male 30day    187 adult female 01day    411 adult female 05day    223 adult female 30day    176 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (140) embryo 02-04hr  (240) embryo 04-06hr  (215) embryo 06-08hr  (180) embryo 08-10hr  (169) embryo 10-12hr  (207) embryo 12-14hr  (155) embryo 14-16hr  (167) embryo 16-18hr  (205) embryo 18-20hr  (292) embryo 20-22hr  (347) embryo 22-24hr  (322) larva L1  (350) larva L2  (418) larva L3 12hr old  (367) larva L3 puffstage 1-2  (215) larva L3 puffstage 3-6  (122) larva L3 puffstage 7-9  (116) white prepupae new  (106) white prepupae 12hr  (91) white prepupae 24hr  (101) pupae 2d postWPP  (178) pupae 3d postWPP  (375) pupae 4d postWPP  (498) adult male 01day  (529) adult male 05day  (422) adult male 30day  (187) adult female 01day  (411) adult female 05day  (223) adult female 30day  (176) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  140 embryo 02-04hr  (240) embryo 04-06hr  (215) embryo 06-08hr  (180) embryo 08-10hr  (169) embryo 10-12hr  (207) embryo 12-14hr  (155) embryo 14-16hr  (167) embryo 16-18hr  (205) embryo 18-20hr  (292) embryo 20-22hr  (347) embryo 22-24hr  (322) larva L1  (350) larva L2  (418) larva L3 12hr old  (367) larva L3 puffstage 1-2  (215) larva L3 puffstage 3-6  122 larva L3 puffstage 7-9  116 white prepupae new  106 white prepupae 12hr    91 white prepupae 24hr  101 pupae 2d postWPP  (178) pupae 3d postWPP  (375) pupae 4d postWPP  (498) adult male 01day  (529) adult male 05day  (422) adult male 30day  (187) adult female 01day  (411) adult female 05day  (223) adult female 30day  (176) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    140 embryo 02-04hr    240 embryo 04-06hr    215 embryo 06-08hr    180 embryo 08-10hr    169 embryo 10-12hr    207 embryo 12-14hr    155 embryo 14-16hr    167 embryo 16-18hr    205 embryo 18-20hr    292 embryo 20-22hr    347 embryo 22-24hr    322 larva L1    350 larva L2    418 larva L3 12hr old    367 larva L3 puffstage 1-2    215 larva L3 puffstage 3-6    122 larva L3 puffstage 7-9    116 white prepupae new    106 white prepupae 12hr    91 white prepupae 24hr    101 pupae 2d postWPP    178 pupae 3d postWPP    375 pupae 4d postWPP    498 adult male 01day    529 adult male 05day    422 adult male 30day    187 adult female 01day    411 adult female 05day    223 adult female 30day    176 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    143 embryonic 1182-4H    88 embryonic GM2    76 embryonic Kc167    92 embryonic S1    302 embryonic S3    167 leg disc CME L1    120 wing disc CME-W2    158 wing disc ML-DmD8    130 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    285 wing disc ML-DmD32    121 haltere disc ML-DmD17-c3    162 eye-antennal disc ML-DmD11    389 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    128 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    116 tumorous blood cells mbn2    95 ovary fGS/OSS    37 ovary OSC    62 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (143) embryonic 1182-4H  (88) embryonic GM2  (76) embryonic Kc167  (92) embryonic S1  (302) embryonic S3  (167) leg disc CME L1  (120) wing disc CME-W2  (158) wing disc ML-DmD8  (130) wing disc ML-DmD9  (140) wing disc ML-DmD16-c3  (100) wing disc ML-DmD21  (285) wing disc ML-DmD32  (121) haltere disc ML-DmD17-c3  (162) eye-antennal disc ML-DmD11  (389) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (128) CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  (116) tumorous blood cells mbn2  (95) ovary fGS/OSS  (37) ovary OSC  (62) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (143) embryonic 1182-4H    88 embryonic GM2    76 embryonic Kc167    92 embryonic S1  (302) embryonic S3  (167) leg disc CME L1  (120) wing disc CME-W2  (158) wing disc ML-DmD8  (130) wing disc ML-DmD9  (140) wing disc ML-DmD16-c3    100 wing disc ML-DmD21  (285) wing disc ML-DmD32  (121) haltere disc ML-DmD17-c3  (162) eye-antennal disc ML-DmD11  (389) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (128) CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  (116) tumorous blood cells mbn2    95 ovary fGS/OSS    37 ovary OSC    62 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    143 embryonic 1182-4H    88 embryonic GM2    76 embryonic Kc167    92 embryonic S1    302 embryonic S3    167 leg disc CME L1    120 wing disc CME-W2    158 wing disc ML-DmD8    130 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    285 wing disc ML-DmD32    121 haltere disc ML-DmD17-c3    162 eye-antennal disc ML-DmD11    389 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    128 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    116 tumorous blood cells mbn2    95 ovary fGS/OSS    37 ovary OSC    62 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    143 embryonic 1182-4H    88 embryonic GM2    76 embryonic Kc167    92 embryonic S1    302 embryonic S3    167 leg disc CME L1    120 wing disc CME-W2    158 wing disc ML-DmD8    130 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    285 wing disc ML-DmD32    121 haltere disc ML-DmD17-c3    162 eye-antennal disc ML-DmD11    389 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    128 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    116 tumorous blood cells mbn2    95 ovary fGS/OSS    37 ovary OSC    62 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (143) embryonic 1182-4H  (88) embryonic GM2  (76) embryonic Kc167  (92) embryonic S1  (302) embryonic S3  (167) leg disc CME L1  (120) wing disc CME-W2  (158) wing disc ML-DmD8  (130) wing disc ML-DmD9  (140) wing disc ML-DmD16-c3  (100) wing disc ML-DmD21  (285) wing disc ML-DmD32  (121) haltere disc ML-DmD17-c3  (162) eye-antennal disc ML-DmD11  (389) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (128) CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  (116) tumorous blood cells mbn2  (95) ovary fGS/OSS  (37) ovary OSC  (62) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  126 Schneider line 2 Sg4  143 embryonic 1182-4H    88 embryonic GM2    76 embryonic Kc167    92 embryonic S1  (302) embryonic S3  (167) leg disc CME L1  120 wing disc CME-W2  (158) wing disc ML-DmD8  130 wing disc ML-DmD9  140 wing disc ML-DmD16-c3    100 wing disc ML-DmD21  (285) wing disc ML-DmD32  121 haltere disc ML-DmD17-c3  (162) eye-antennal disc ML-DmD11  (389) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  128 CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  116 tumorous blood cells mbn2    95 ovary fGS/OSS    37 ovary OSC    62 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    143 embryonic 1182-4H    88 embryonic GM2    76 embryonic Kc167    92 embryonic S1    302 embryonic S3    167 leg disc CME L1    120 wing disc CME-W2    158 wing disc ML-DmD8    130 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    285 wing disc ML-DmD32    121 haltere disc ML-DmD17-c3    162 eye-antennal disc ML-DmD11    389 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    128 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    116 tumorous blood cells mbn2    95 ovary fGS/OSS    37 ovary OSC    62 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    29 heat shock, 4-day adult    185 Cadmium 50 mM 6 hrs, larvae L3    273 Cadmium 50 mM 12 hrs, larvae L3    152 Cadmium 50 mM 48 hrs, 4-day adult    152 Cadmium 100 mM 48 hrs, 4-day adult    92 Copper 0.5 mM 12 hrs, larvae L3    132 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    62 Zinc 4.5 mM 48 hrs, 4-day adult    64 Ethanol 2.5% 3 hrs, larvae L3    184 Ethanol 5% 3 hrs, larvae L3    256 Ethanol 10% 3 hrs, larvae L3    290 Caffeine 1.5 mg/ml 4 hrs, larvae L3    228 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    85 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    155 Paraquat 10 mM 48 hrs, 4-day adult    179 Rotenone 2 μg 12 hrs, larvae L3    317 Rotenone 8 μg 12 hrs, larvae L3    381 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  (29) heat shock, 4-day adult  (185) Cadmium 50 mM 6 hrs, larvae L3  (273) Cadmium 50 mM 12 hrs, larvae L3  (152) Cadmium 50 mM 48 hrs, 4-day adult  (152) Cadmium 100 mM 48 hrs, 4-day adult  (92) Copper 0.5 mM 12 hrs, larvae L3  (132) Copper 15 mM 48 hrs, 4-day adult  (76) Zinc 5 mM 12 hrs, larvae L3  (62) Zinc 4.5 mM 48 hrs, 4-day adult  (64) Ethanol 2.5% 3 hrs, larvae L3  (184) Ethanol 5% 3 hrs, larvae L3  (256) Ethanol 10% 3 hrs, larvae L3  (290) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (228) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (85) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (155) Paraquat 10 mM 48 hrs, 4-day adult  (179) Rotenone 2 μg 12 hrs, larvae L3  (317) Rotenone 8 μg 12 hrs, larvae L3  (381) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    29 heat shock, 4-day adult  (185) Cadmium 50 mM 6 hrs, larvae L3  (273) Cadmium 50 mM 12 hrs, larvae L3  (152) Cadmium 50 mM 48 hrs, 4-day adult  (152) Cadmium 100 mM 48 hrs, 4-day adult    92 Copper 0.5 mM 12 hrs, larvae L3  (132) Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    62 Zinc 4.5 mM 48 hrs, 4-day adult    64 Ethanol 2.5% 3 hrs, larvae L3  (184) Ethanol 5% 3 hrs, larvae L3  (256) Ethanol 10% 3 hrs, larvae L3  (290) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (228) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    85 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult  (155) Paraquat 10 mM 48 hrs, 4-day adult  (179) Rotenone 2 μg 12 hrs, larvae L3  (317) Rotenone 8 μg 12 hrs, larvae L3  (381) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    29 heat shock, 4-day adult    185 Cadmium 50 mM 6 hrs, larvae L3    273 Cadmium 50 mM 12 hrs, larvae L3    152 Cadmium 50 mM 48 hrs, 4-day adult    152 Cadmium 100 mM 48 hrs, 4-day adult    92 Copper 0.5 mM 12 hrs, larvae L3    132 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    62 Zinc 4.5 mM 48 hrs, 4-day adult    64 Ethanol 2.5% 3 hrs, larvae L3    184 Ethanol 5% 3 hrs, larvae L3    256 Ethanol 10% 3 hrs, larvae L3    290 Caffeine 1.5 mg/ml 4 hrs, larvae L3    228 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    85 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    155 Paraquat 10 mM 48 hrs, 4-day adult    179 Rotenone 2 μg 12 hrs, larvae L3    317 Rotenone 8 μg 12 hrs, larvae L3    381 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    29 heat shock, 4-day adult    185 Cadmium 50 mM 6 hrs, larvae L3    273 Cadmium 50 mM 12 hrs, larvae L3    152 Cadmium 50 mM 48 hrs, 4-day adult    152 Cadmium 100 mM 48 hrs, 4-day adult    92 Copper 0.5 mM 12 hrs, larvae L3    132 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    62 Zinc 4.5 mM 48 hrs, 4-day adult    64 Ethanol 2.5% 3 hrs, larvae L3    184 Ethanol 5% 3 hrs, larvae L3    256 Ethanol 10% 3 hrs, larvae L3    290 Caffeine 1.5 mg/ml 4 hrs, larvae L3    228 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    85 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    155 Paraquat 10 mM 48 hrs, 4-day adult    179 Rotenone 2 μg 12 hrs, larvae L3    317 Rotenone 8 μg 12 hrs, larvae L3    381 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  29 heat shock, 4-day adult  (185) Cadmium 50 mM 6 hrs, larvae L3  (273) Cadmium 50 mM 12 hrs, larvae L3  (152) Cadmium 50 mM 48 hrs, 4-day adult  (152) Cadmium 100 mM 48 hrs, 4-day adult  (92) Copper 0.5 mM 12 hrs, larvae L3  (132) Copper 15 mM 48 hrs, 4-day adult  (76) Zinc 5 mM 12 hrs, larvae L3  (62) Zinc 4.5 mM 48 hrs, 4-day adult  (64) Ethanol 2.5% 3 hrs, larvae L3  (184) Ethanol 5% 3 hrs, larvae L3  (256) Ethanol 10% 3 hrs, larvae L3  (290) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (228) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (85) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (155) Paraquat 10 mM 48 hrs, 4-day adult  (179) Rotenone 2 μg 12 hrs, larvae L3  (317) Rotenone 8 μg 12 hrs, larvae L3  (381) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    29 heat shock, 4-day adult  (185) Cadmium 50 mM 6 hrs, larvae L3  (273) Cadmium 50 mM 12 hrs, larvae L3  (152) Cadmium 50 mM 48 hrs, 4-day adult  (152) Cadmium 100 mM 48 hrs, 4-day adult    92 Copper 0.5 mM 12 hrs, larvae L3  132 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    62 Zinc 4.5 mM 48 hrs, 4-day adult    64 Ethanol 2.5% 3 hrs, larvae L3  (184) Ethanol 5% 3 hrs, larvae L3  (256) Ethanol 10% 3 hrs, larvae L3  (290) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (228) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    85 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult  (155) Paraquat 10 mM 48 hrs, 4-day adult  (179) Rotenone 2 μg 12 hrs, larvae L3  (317) Rotenone 8 μg 12 hrs, larvae L3  (381) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    29 heat shock, 4-day adult    185 Cadmium 50 mM 6 hrs, larvae L3    273 Cadmium 50 mM 12 hrs, larvae L3    152 Cadmium 50 mM 48 hrs, 4-day adult    152 Cadmium 100 mM 48 hrs, 4-day adult    92 Copper 0.5 mM 12 hrs, larvae L3    132 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    62 Zinc 4.5 mM 48 hrs, 4-day adult    64 Ethanol 2.5% 3 hrs, larvae L3    184 Ethanol 5% 3 hrs, larvae L3    256 Ethanol 10% 3 hrs, larvae L3    290 Caffeine 1.5 mg/ml 4 hrs, larvae L3    228 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    85 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    155 Paraquat 10 mM 48 hrs, 4-day adult    179 Rotenone 2 μg 12 hrs, larvae L3    317 Rotenone 8 μg 12 hrs, larvae L3    381 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • RE20862 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010612 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6105-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for l(2)06225 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive l(2)0622506225 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of l(2)06225 Class Mutagen Stocks Known lesion l(2)0622506225 P-element activity 1 Yes l(2)06225G12874 P-element activity 1 -- l(2)06225e02551 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)06225 Class Mutagen Stocks Known lesion l(2)06225KK108323 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)06225GD13705 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)Δ37 (Zallen et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13705} NA P{KK108323} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}l(2)0622506225 No miscellaneous insertions P{PTT-GB}CB03272 NA PBac{RB}l(2)06225e02551 NA insertion of mobile activating element P{EP}SCARG12874 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
hydrogen-exporting ATPase activity, phosphorylative mechanism inferred from sequence or structural similarity with UniProtKB:O75964 (Sardiello et al., 2003.6.11) inferred from sequence or structural similarity with UniProtKB:Q28852 (FlyBase, 1992-)
Biological Process
CV term Evidence References
ATP synthesis coupled proton transport inferred from electronic annotation with InterPro:IPR006808 (FlyBase Curators et al., 2004-) proton transport inferred from sequence or structural similarity with UniProtKB:O75964 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) inferred from sequence or structural similarity with UniProtKB:O75964 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
l(2)06225 - ATPsyn-Cf6 experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - ATPsyn-b anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) l(2)06225 - ATPsyn-d experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - CG11857 experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)06225 - CG3321 experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - CG4692 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) l(2)06225 - Jwa experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - Oscp anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) l(2)06225 - Scamp experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)06225 - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)06225 - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)06225 - l(1)G0230 experimental knowledge based (Guruharsha et al., 2011) l(2)06225 - sun experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)06225 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70084 DroID - A comprehensive database of gene and protein interactions. • FBgn0010612 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46069
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G1N34 Dipteran inclusive ortholog search EOG6ZPF4V Insect inclusive ortholog search EOG6MSBW5 Arthropod inclusive ortholog search EOG6M37SJ Metazoa inclusive ortholog search EOG6XHBVS
Orthologs in Drosophila Species (EOG6G1N34)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\l(2)06225     Drosophila simulans   Dsim\GD22207 Y   Drosophila sechellia   Dsec\GM11242 Y   Drosophila erecta   Dere\GG10338 Y   Drosophila yakuba   Dyak\l(2)06225 Y   Drosophila ananassae   Dana\GF14048 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19355 Y   Drosophila persimilis   Dper\GL19020 Y   Drosophila willistoni   Dwil\GK15246 Y   Drosophila virilis   Dvir\GJ14568 Y   Drosophila mojavensis   Dmoj\GI18153 Y   Drosophila grimshawi   Dgri\GH10969 Y
Orthologs in non-Drosophila Dipterans (EOG6ZPF4V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006509   Anopheles gambiae Malaria mosquito  Agam\AGAP009491   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801865
Orthologs in non-Dipteran Insects (EOG6MSBW5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45434 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007462 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14631 Y Atta cephalotes Leafcutter ant  Acep\ACEP11932 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15009 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16447 Y Linepithema humile Argentine ant  Lhum\LH25227 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18413 Y Solenopsis invicta Red fire ant  Sinv\SINV24025 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000043 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013511 Y Pediculus humanus Human body louse  Phum\PHUM401980 Y Tribolium castaneum Red flour beetle  Tcas\ATP20 Y
Orthologs in non-Insect Arthropods (EOG6M37SJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_230756 Y Ixodes scapularis Deer tick  Isca\ISCW007401 Y
Orthologs in non-Arthropod Metazoa (EOG6XHBVS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\asg-1 Y Caenorhabditis elegans Nematode  Cele\asg-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003273gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013135gn Y Danio rerio Zebrafish  Drer\atp5l Y Xenopus tropicalis Western clawed frog  Xtro\atp5l Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000006899 Y Mus musculus House mouse  Mmus\Atp5l Y Mus musculus House mouse  Mmus\Atp5l-ps1 Y Rattus norvegicus Norway rat  Rnor\LOC679690 Y Rattus norvegicus Norway rat  Rnor\LOC679586 Y Rattus norvegicus Norway rat  Rnor\Atp5l Y Rattus norvegicus Norway rat  Rnor\LOC100360369 Y Rattus norvegicus Norway rat  Rnor\RGD1565438 Y Homo sapiens Human  Hsap\ATP5L2 Y Homo sapiens Human  Hsap\ATP5L Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ATP5L2     Hsap\ATP5L
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22207 Drosophila sechellia Dsec\GM11242 Drosophila erecta Dere\GG10338 Drosophila yakuba Dyak\l(2)06225 Drosophila ananassae Dana\GF14048 Drosophila pseudoobscura pseudoobscura Dpse\GA19355 Drosophila persimilis Dper\GL19020 Drosophila willistoni Dwil\GK15246 Drosophila virilis Dvir\GJ14568 Drosophila mojavensis Dmoj\GI18153 Drosophila grimshawi Dgri\GH10969
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	11476 P{PZ}l(2)0622506225 cn1/CyO; ry506 28390 y1 w*; P{EP}SCARG12874 l(2)06225G12874
VDRC	v107311 P{KK108323}VIE-260B
Genomic Clones ( 2 )
	BACR03D06 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 262 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08468 RE20862 RH28372
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11023 GH09483 GH12084 GH15786 GM26276 GM29034 RE23185 RE44133 RE45493 RE54008 RE56759 RE61816 RE65115 RH02589 RH03518 RH06151 RH06239 RH07279 RH07446 RH07488 RH07489 RH08459 RH10871 RH13751 RH15907 RH16080 RH18660 RH19617 RH19760 RH19776 RH19843 RH20030 RH20150 RH21316 RH24520 RH24525 RH25324 RH25336 RH26859 RH27010 RH27520 RH27958 RH29669 RH29710 RH31253 RH32153 RH32452 RH35581 RH36224 RH36833 RH37654 RH37794 RH38128 RH38659 RH38688 RH39427 RH40114 RH42711 RH47258 RH47560 RH47847 RH48003 RH49796 RH54586 RH54735 RH58525 RH59053 RH60360 RH60772 RH63088 RH63592 RH64780 RH66193 RH68790 RH69140 RH70094 RH70685 RH72641 RH72692 RH72964 RH74748
Other clones	35947 50432 61554 77992 291229 bs09g12 bs12b05 bs15g05 bs35e01 bs39b12 CK01.53D.D1 CK01.112D.F6 CK00491 Dmel_dig_011276_0597_2031 Dmel_dig_015198_0617_2376 Dmel_dig_015318_0645_3263 Dmel_dig_017063_0712_3729 Dmel_dig_017450_0656_1042 Dmel_neb_003655_0698_0353 Dmel_neb_005250_0663_0361 Dmel_neb_013131_0687_1122 Dmel_neb_013359_0447_1710 Dmel_neb_013737_0825_2288 Dmel_neb_015421_0895_0883 Dmel_neb_016129_0612_1650 EK009740 EK043413 EK107002 EK146839 EK187230 EK213331 EK214506 EN06527 EN13530 FGC031A06 FGH103F02 FGM217G08 FGM220G06 LP08385 RP003008208 RP003035522 RP003045942 RP003053186 RP003053711 RP003055893 RP003060734 RP003062221 RP003068623 RP003077565 RP003081655 RP003087889 RP003088881 RP003104657 RP003116676 RP003116769 RP003118729 RP003121274 RP003141207 RP003146394 RP003149502 RP003149743 RP003153417 RP003155715 RP003161251 RP003168181 RP003171182 RP003171200 RP003174378 RP003176096 RP003186802 RP003186817 RP003187484 RP003189242 RP003189628 RP003194664 RP003199020 RP003199591 RP003199999 RP003207669 RP003212923 RP003214750 RP003217078 RP003224638 RP003225588 RP003227117 RP003240458 RP003242048 RP003248336 RP003250770 RP003251436 RP003257506 RP003263511 RP003273804 RP003273896 RP003277370 RP003280716 RP003284691 RP003284837 RP003285978 RP003291159 RP003293880 RP003294068 RP003306913 RP003307433 RP003315749 RP003319120 RP003319748 RP003321390 RP003322486 RP003323974 RP003330453 RP003333113 RP003335016 RP003335139 RP003335232 RP003337172 RP003339831 RP003344431 RP003344575 RP003349445 RP003351845 RP003358615 RP003365913 RP003379692 RP003381019 RP003385779 RP003385920 RP003389770 RP003399986 RP003419057 RP003432553 RP003437925 RP003461675 RP003467101 RP003470531 RP003474379 RP003478830 RP003492897 RP003495001 RP003505664 RP003508368 RP003512979 RP003527306 RP003527556 RP003528962 RP003554513 RP003556610 RP003556967 RP003559638 RP003575060 RP003576437 RP003580541 RP003589399 RP003594683 RP003597435 RP003605416 RP003607556 RP003609686 RP003611162 RP003612195 RP003621375 RP003626379 RP003626435 RP003635007 RP003635033 RP003639916 RP003645482 RP003647121 RP003647205 RP003653667 RP003657037 RP003666947 RP003670134 RP003670616 RP003672838 RP003675833 RP003676317 RP003680729
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010612 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46069
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6105 anon-EST:Posey10 (Bayraktaroglu, 2000.11.2) Source for merge of: l(2)06225 BcDNA:RE20862 (FlyBase, 1996-) Source for merge of: l(2)06225 BcDNA:RH28372 (FlyBase, 1996-) Source for merge of: l(2)06225 CG6105 (Misra, 2000.11.18)
Additional comments	Source for merge of l(2)06225 BcDNA:RH28372 was TrEMBL update (date:020807). (FlyBase, 1996-) Source for merge of l(2)06225 BcDNA:RE20862 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143778 NM_001042888 NM_001042889 RefSeq (Proteins) • NP_652035 NP_001036353 NP_001036354 DDBJ / EMBL / GenBank • AAF53041 AAL48164 AAL48787 ABI31307 ABI31308 AF083297 AI134581 AI945176 AI945370 AI945695 AI947132 AQ025646 AY070693 AY071165 BI214747 BI587639 Entrez Gene - A searchable database of RefSeq genes. • 46069 UniProtKB/TrEMBL • Q9VKM3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, F0 complex, subunit G, mitochondrial (IPR006808) Mitochondrial ATP synthase subunit g, animal (IPR016702) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06105 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE20862
Linkouts
	BioGRID - A database of protein and genetic interactions • 70084 DroID - A comprehensive database of gene and protein interactions. • FBgn0010612 DRSC - Results from RNAi screens. • FBgn0010612 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010612 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6105-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010612 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46069 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46069 modMine - Data generated by the modENCODE project. • FBgn0010612
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-EST:Posey10   BcDNA:RE20862   BcDNA:RH28372   CG6105 (Porcelli et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) I(2)06225 (Pedra et al., 2004) l(2)06225 (Beller et al., 2006, Buszczak et al., 2007, Dorus et al., 2006, Tripoli et al., 2005, Ladoukakis et al., 2011, Siddiqui et al., 2012, Malone et al., 2012)
Name Synonym	ATP synthase G chain (Tripoli et al., 2005) F0/F1 ATP synthase G (Porcelli et al., 2007) lethal (2) 06225 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0025552 FBgn0032325 FBgn0047026 FBgn0047151
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Siddiqui et al., 2012, Genome Biol. 13(2): R11 Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. [FBrf0218847] Ladoukakis et al., 2011, Genome Biol. 12(11): R118 Hundreds of putatively functional small open reading frames in Drosophila. [FBrf0218190] Show all research papers ...