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Gene Dmel\Atg6

General Information
Symbol	Dmel\Atg6	Species	D. melanogaster
Name	Autophagy-specific gene 6	Annotation symbol	CG5429
Feature type	protein_coding_gene	FlyBase ID	FBgn0010709
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(3)00096
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95D10-95D10	Sequence location	3R:19,874,893..19,876,735 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Autophagy-specific gene 6 is referred to in FlyBase by the symbol Dmel\Atg6 (CG5429, FBgn0010709). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Autophagy-related protein 6. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1636499_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Atg6. Gene sequence location is 3R:19874893..19876735.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA15798 BKN22541
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95D10-95D10   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95D10-95D11   (determined by in situ hybridisation)   (Spradling et al., 1999) 95D10-95D11     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Atg6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Atg6-RA FBtr0084590  NM_142952   1733   422
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Atg6-PA   FBpp0083975   48.9   422   4.53     NP_651209   AAF56227
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Autophagy-related protein 6 (IPR007243)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA817351   AA941161   AA950415   AE014297 AAF56227   AI109821   AI455933   AI517813   AI531006   AQ026153   AW943297   AY061424 AAL28972   BF485603   BI233255   BI237767   BI639270   BP553942   BP553943   CO268253   CO307361   CO332351   EC089949   EC203637   EC228196   EC231543   EC257202   GH749616   GH750467   GH750680   GH751491   GH752184   GH752246   GH755180   GH755952   GH756616   GH757161   GH758292   GH758652   GH759070   GH759813   GH770406   GH771259   GH772742   GH773171   GH776684   GH781541   GH784181   GH784674   GH784894   GH785146   GH786287   GH786969   GH789659   GH790421   GH791612   GH793054   GH793333   GH793615   GH794735   GH795283   GH796999   GH798866   GH800258   GH800548   GH800589   GH800677   GH801077   GH802291   GH809871   GH811710   GH812495   GH812574   GH814885   GH815903   GH816150   GH817233   GH819395   GH822541   GH823931   GH825146   GH825752   GH826502   GH827124   GH827876   GH828562   GH829187   GH829899   GH830122   GH830692   GH831623   GH833126   GH834602   GH834841   GH836206   GH837550   GH837741   GH839905   GH841590   GH841790   GH842853   GH845809   GH846569   GH846639   GH850620   GH850757   GH851842   GH853177   GH853310   GH853442   GH854627   GH854922   GH857418   GH857693   GH859782   GH860145   GH862642   GH863161   GH867108   GH867197   GH869163   GH870313   GH870449   GH870708   GH870802   GH871494   GH872508   GH872800   GH873082   GH874843   GH876649   GH879193   GH881121   GH881994   GH882380   GH882500   GH884116   GH884316   GH884388   GH891506   GH893058   GH895404   GH899253   GH899261   GH902894   GH905437   GH907480   GH907919   GH908682   GH910290   GH911125   GH911486   GH912404   GH914262   GH914531   GH915154   GH916933   GH919307   GH921247   GH922179   GH924841   GH926138   GH926478   GH926533   GH926763   GH926968   GH931013   GH931345   GH932634   GH934272   GH934774   GH939089
UniProtKB/Swiss-Prot	Q9VCE1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010709    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010709 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010709 expression level Developmental Stage   Expression Level embryo 00-02hr    1454 embryo 02-04hr    1273 embryo 04-06hr    1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1454) embryo 02-04hr  (1273) embryo 04-06hr  (1532) embryo 06-08hr  (1352) embryo 08-10hr  (1129) embryo 10-12hr  (1262) embryo 12-14hr  (1012) embryo 14-16hr  (863) embryo 16-18hr  (1035) embryo 18-20hr  (1242) embryo 20-22hr  (1104) embryo 22-24hr  (1273) larva L1  (890) larva L2  (744) larva L3 12hr old  (620) larva L3 puffstage 1-2  (773) larva L3 puffstage 3-6  (1025) larva L3 puffstage 7-9  (1303) white prepupae new  (1266) white prepupae 12hr  (1118) white prepupae 24hr  (1117) pupae 2d postWPP  (982) pupae 3d postWPP  (719) pupae 4d postWPP  (1117) adult male 01day  (825) adult male 05day  (969) adult male 30day  (928) adult female 01day  (902) adult female 05day  (1092) adult female 30day  (1144) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1454 embryo 02-04hr    1273 embryo 04-06hr  (1532) embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1454 embryo 02-04hr    1273 embryo 04-06hr    1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1454 embryo 02-04hr    1273 embryo 04-06hr    1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010709 expression level Developmental Stage   Expression Level embryo 00-02hr    1454 embryo 02-04hr    1273 embryo 04-06hr    1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1454) embryo 02-04hr  (1273) embryo 04-06hr  (1532) embryo 06-08hr  (1352) embryo 08-10hr  (1129) embryo 10-12hr  (1262) embryo 12-14hr  (1012) embryo 14-16hr  (863) embryo 16-18hr  (1035) embryo 18-20hr  (1242) embryo 20-22hr  (1104) embryo 22-24hr  (1273) larva L1  (890) larva L2  (744) larva L3 12hr old  (620) larva L3 puffstage 1-2  (773) larva L3 puffstage 3-6  (1025) larva L3 puffstage 7-9  (1303) white prepupae new  (1266) white prepupae 12hr  (1118) white prepupae 24hr  (1117) pupae 2d postWPP  (982) pupae 3d postWPP  (719) pupae 4d postWPP  (1117) adult male 01day  (825) adult male 05day  (969) adult male 30day  (928) adult female 01day  (902) adult female 05day  (1092) adult female 30day  (1144) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1454 embryo 02-04hr    1273 embryo 04-06hr  1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1454 embryo 02-04hr    1273 embryo 04-06hr    1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1454 embryo 02-04hr    1273 embryo 04-06hr    1532 embryo 06-08hr    1352 embryo 08-10hr    1129 embryo 10-12hr    1262 embryo 12-14hr    1012 embryo 14-16hr    863 embryo 16-18hr    1035 embryo 18-20hr    1242 embryo 20-22hr    1104 embryo 22-24hr    1273 larva L1    890 larva L2    744 larva L3 12hr old    620 larva L3 puffstage 1-2    773 larva L3 puffstage 3-6    1025 larva L3 puffstage 7-9    1303 white prepupae new    1266 white prepupae 12hr    1118 white prepupae 24hr    1117 pupae 2d postWPP    982 pupae 3d postWPP    719 pupae 4d postWPP    1117 adult male 01day    825 adult male 05day    969 adult male 30day    928 adult female 01day    902 adult female 05day    1092 adult female 30day    1144 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010709    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010709 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010709 expression level Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010709 expression level Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    147.65 Larval Midgut    111 Larval Hindgut    107.3 Larval Malpighian Tubules    153.7 Larval Fat Body    123 Larval Salivary Gland    142.3 Larval Trachea    129 Larval Carcass    110.325 Adult Head    113.2 Adult Eye    225.575 Adult Brain    166.2 Adult Thoracic-Abdominal Ganglion    149.7 Adult Crop    123.3 Adult Midgut    125.6 Adult Hindgut    120.4 Adult Malpighian Tubules    151.9 Adult Fat Body    88.7 Adult Salivary Gland    253.9 Adult Heart    93.9 Adult VirginFemale Spermatheca    90.8 Adult InseminatedFemale Spermatheca    77.5 Adult Ovary    120.9 Adult Testis    67.3 Adult Male Accessory Gland    162.2 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    113.2   NA  Eye    225.575   NA  Brain    166.2   147.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    149.7   NA  Crop    123.3   111  Midgut    125.6   107.3  Hindgut    120.4   153.7  Malpighian Tubules    151.9   123  Fat Body    88.7   142.3  Salivary Gland    253.9   NA  Heart    93.9   129  Trachea    NA   NA  VirginFemale Spermatheca    90.8   NA  InseminatedFemale Spermatheca    77.5   NA  Ovary    120.9   NA  Testis    67.3   NA  Male Accessory Gland    162.2   110.325  Carcass    82.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5429-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive Atg600096 lethal | recessive Atg600096 semi-lethal Atg600096 semi-lethal | recessive Atg600096 viable, with Scer\GAL4pnr-MD237 Atg6GD11647 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Atg6 Class Mutagen Stocks Known lesion Atg600096 P-element activity 1 -- Atg6GS3199 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Atg6 Class Mutagen Stocks Known lesion Atg6GD11647 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Atg6HMS01483 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg6JF02897 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg6dsRNA.Scer\UAS in vitro construct - RNAi 0 Yes Atg6KK102460 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Atg6Scer\UAS.cJa in vitro construct - regulatory fusion 0 Yes Atg6Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)crb87-4 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3R)Exel6197 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11647} NA P{KK102460} NA P{TRiP.HMS01483} NA P{TRiP.JF02897} NA P{UAS-Atg6.KD} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Atg600096 No insertion of mobile activating element P{GSV1}CG5991GS3199 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagy inferred from electronic annotation with InterPro:IPR007243 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Atg6 allele Gene References unspecified bchs (Simonsen et al., 2007) Prosβ2 (Pandey et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67784 DroID - A comprehensive database of gene and protein interactions. • FBgn0010709 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42850
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17966 Dere\GG12379 Dgri\GH19099 Dmoj\GI22959 Dper\GL24151 Dpse\GA18874 Dsec\GM23517 Dsim\GD18327 Dvir\GJ14539 Dwil\GK11938 Dyak\Atg6
Curated drosophilid orthologs	Dpse\GA18874   Dyak\Atg6 (Oriol, 2005.7.25)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010427-PA Aedes aegypti (mosquito) AGAP003858-PA Anopheles gambiae (mosquito) XP_392365.1 Apis mellifera (honey bee) XP_001950923.1 Acyrthosiphon pisum (pea aphid) At3g61710.1 Arabidopsis thaliana (wall cress) 80956 Branchiostoma floridae (lancelet) 84223 Branchiostoma floridae (lancelet) BGIBMGA000092-PA Bombyx mori (silk worm) ENSBTAP00000026531 Bos taurus (bovine) CAL0004212 Candida albicans (a form of yeast) CN23383 Caenorhabditis brenneri (small nematode) CBP04654 Caenorhabditis briggsae (nematode) CE27592 Caenorhabditis elegans (worm) ENSCAFP00000021764 Canis familiaris (dog) CAGL0J06886g Candida glabrata (haploid yeast) Chro.60035 Cryptosporidium hominis (obligate parasite) ENSCINP00000019537 Ciona intestinalis (sea squirt) JA13078 Caenorhabditis japonica (nematode) cn03455 Cryptococcus neoformans (yeast-like fungus) cgd6_230 Cryptosporidium parvum (protozoan parasite) CPIJ011087 Culex pipens (mosquito) ENSCPOP00000011290 Cavia porcellus (guinea pig) 101560 Chlamidomonas reinhardtii (green alga) RP37289 Caenorhabditis remanei (nematode) RP47449 Caenorhabditis remanei (nematode) ENSCSAVP00000010497 Ciona savignyi (sedentary tunicate) 124048 Capitella spl (polychaete worm) DDB0220127 Dictyostelium discoideum (amoeba) DEHA2E16214g Debaryomyces Hansenii (yeast) 128719 Daphnia pulex (daphnia) ENSECAP00000016069 Equus caballus (horse) ENSGACP00000008498 Gymnopilus aculeatus (mushroom) ENSGALP00000004697 Gallus gallus (chicken) 78607 Hypsipyla robusta (cedar shoot borer) ENSP00000355231 Homo sapiens (human) ISCW014200-PA Ixodes scapularis (deer tick) KLLA0F01166g Kluyveromyces lactis (yeast) 226844 Lottia gigantea (owl limpet) ENSMODP00000018835 Monodelphis domestica (gray opossum) ENSMMUP00000034400 Macaca mulatta (rhesus monkey) ENSMUSP00000040094 Mus musculus (house mouse) 100769 Nematostella vectensis (starlet anemone) XP_001601439.1 Nasonia vitripennis (wasp) ENSOANP00000019267 Ornithorynchus anatinus (platypus) ENSORLP00000005780 Oryzias latipes (japanese killifish) LOC_Os03g44200.1 Oryza sativa (asian rice) 5989 Ostreococcus tauri (green alga) PHUM002182-PA Pediculus humanus (human body louse) 124820 Physcomitrella patens (moss) ENSPPYP00000009414 Pongo pygmaeus (orangutan) 80430 Phytophthora ramorum (sudden oak death pathogen) 128490 Phytophthora sojae (root rot pathogen) 816633 Populus trichocarpa (black cottonwood) ENSPTRP00000046569 Pan troglodytes (chimpanzee) ENSRNOP00000027868 Rattus norvegicus (norway rat) 5003175 Sorghum bicolor (sorghum) YPL120W Saccharomyces cerevisiae (budding yeast) Smp_048990 Schistosoma mansoni (trematode parasite) SPAC20G8.10c Schizosaccharomyces pombe (fission yeast) XP_786368.2 Strongylocentrotus purpuratus (purple sea urchin) 54385 Trichoplax adhaerens (metazoa) XP_971293.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014523 Tetraodon nigroviridis (green spotted pufferfish) 8428 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034988 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027611 Xenopus tropicalis (frog) YALI0D11968g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15432 LH14136 ISCW014200 FBgn0083333 FBgn0213949 FBgn0201750 FBgn0189857 FBgn0178383 JGI_V11_128719 FBgn0078874 FBgn0161741 FBgn0145686 FBgn0126566 FBgn0104667 FBgn0094984 CPIJ011087 BGIBMGA000092 ACYPI004000 GB14875 AGAP012793 AGAP003858 AAEL010427 PB24583 PHUM420440 GLEAN_09816
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28060 y1 v1; P{TRiP.JF02897}attP2 35741 y1 sc* v1; P{TRiP.HMS01483}attP2 11487 ry506 P{PZ}Atg600096/TM3, ryRK Sb1 Ser1
VDRC	v22122 w1118; P{GD11647}v22122 v22123 w1118; P{GD11647}v22123
Genomic Clones ( 1 )
	BACR15J11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 164 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35669
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT19531 GH09190 GH28876 LD22607 LD28959 RE29554 RE34058 SD01847 SD21819
Other clones	149333 176031 214223.17 275465 CK01.118A.H11 EK090724 EK254431 EK303228 FGM227B06 RP003001682 RP003013254 RP003031075 RP003036117 RP003036812 RP003036999 RP003041382 RP003052905 RP003057158 RP003061609 RP003067058 RP003076225 RP003077706 RP003087027 RP003095545 RP003097959 RP003099161 RP003100615 RP003103500 RP003112701 RP003120567 RP003122712 RP003123901 RP003126443 RP003129326 RP003129612 RP003132831 RP003134804 RP003141657 RP003141777 RP003144225 RP003159282 RP003162918 RP003168462 RP003170902 RP003172278 RP003172756 RP003177735 RP003185027 RP003189707 RP003193257 RP003198704 RP003207966 RP003219939 RP003220104 RP003225943 RP003228488 RP003229631 RP003230500 RP003231492 RP003250079 RP003254500 RP003255250 RP003256822 RP003265227 RP003268227 RP003269020 RP003270006 RP003271982 RP003272278 RP003282463 RP003286389 RP003288324 RP003290016 RP003293774 RP003296444 RP003298403 RP003301176 RP003303740 RP003306397 RP003308858 RP003309999 RP003312531 RP003314874 RP003318323 RP003320772 RP003320909 RP003322801 RP003325803 RP003332313 RP003343043 RP003343298 RP003344796 RP003352546 RP003359661 RP003371146 RP003377453 RP003383933 RP003386628 RP003386989 RP003389242 RP003391274 RP003395192 RP003397623 RP003398539 RP003400060 RP003412576 RP003418863 RP003420697 RP003427178 RP003440257 RP003441282 RP003442296 RP003444089 RP003453432 RP003459806 RP003463470 RP003471888 RP003471986 RP003473546 RP003478726 RP003478823 RP003478863 RP003479119 RP003480211 RP003480701 RP003485484 RP003491701 RP003498095 RP003518588 RP003520386 RP003525833 RP003526651 RP003527666 RP003533549 RP003542901 RP003548353 RP003548356 RP003554972 RP003563399 RP003581303 RP003583157 RP003590072 RP003612930 RP003615590 RP003617172 RP003623664 RP003624850 RP003630507 RP003638935 RP003640220 RP003640652 RP003641222 RP003642141 RP003665836
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42850
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Atg6 CG5429 (Scott et al., 2004)
Source for database merge of	Source for merge of: CG5429 l(3)00096 (Scott et al., 2004)
Additional comments	FlyBase curator comment: Correspondence with author Naps revealed that 'Beclin1' = 'CG5429'. (Naps and Neufeld, 2008)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142952 RefSeq (Proteins) • NP_651209 DDBJ / EMBL / GenBank • AA941161 AAF56227 AAL28972 AI455933 AQ026153 AW943297 AY061424 Entrez Gene - A searchable database of RefSeq genes. • 42850 UniProtKB/Swiss-Prot • Q9VCE1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Autophagy-related protein 6 (IPR007243)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67784 DroID - A comprehensive database of gene and protein interactions. • FBgn0010709 DRSC - Results from RNAi screens. • FBgn0010709 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5429-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42850 InParanoid A subset of ortholog calls from InParanoid. • AAEL010427-PA Aedes aegypti (mosquito) AGAP003858-PA Anopheles gambiae (mosquito) XP_392365.1 Apis mellifera (honey bee) XP_001950923.1 Acyrthosiphon pisum (pea aphid) At3g61710.1 Arabidopsis thaliana (wall cress) 80956 Branchiostoma floridae (lancelet) 84223 Branchiostoma floridae (lancelet) BGIBMGA000092-PA Bombyx mori (silk worm) ENSBTAP00000026531 Bos taurus (bovine) CAL0004212 Candida albicans (a form of yeast) CN23383 Caenorhabditis brenneri (small nematode) CBP04654 Caenorhabditis briggsae (nematode) CE27592 Caenorhabditis elegans (worm) ENSCAFP00000021764 Canis familiaris (dog) CAGL0J06886g Candida glabrata (haploid yeast) Chro.60035 Cryptosporidium hominis (obligate parasite) ENSCINP00000019537 Ciona intestinalis (sea squirt) JA13078 Caenorhabditis japonica (nematode) cn03455 Cryptococcus neoformans (yeast-like fungus) cgd6_230 Cryptosporidium parvum (protozoan parasite) CPIJ011087 Culex pipens (mosquito) ENSCPOP00000011290 Cavia porcellus (guinea pig) 101560 Chlamidomonas reinhardtii (green alga) RP37289 Caenorhabditis remanei (nematode) RP47449 Caenorhabditis remanei (nematode) ENSCSAVP00000010497 Ciona savignyi (sedentary tunicate) 124048 Capitella spl (polychaete worm) DDB0220127 Dictyostelium discoideum (amoeba) DEHA2E16214g Debaryomyces Hansenii (yeast) 128719 Daphnia pulex (daphnia) ENSECAP00000016069 Equus caballus (horse) ENSGACP00000008498 Gymnopilus aculeatus (mushroom) ENSGALP00000004697 Gallus gallus (chicken) 78607 Hypsipyla robusta (cedar shoot borer) ENSP00000355231 Homo sapiens (human) ISCW014200-PA Ixodes scapularis (deer tick) KLLA0F01166g Kluyveromyces lactis (yeast) 226844 Lottia gigantea (owl limpet) ENSMODP00000018835 Monodelphis domestica (gray opossum) ENSMMUP00000034400 Macaca mulatta (rhesus monkey) ENSMUSP00000040094 Mus musculus (house mouse) 100769 Nematostella vectensis (starlet anemone) XP_001601439.1 Nasonia vitripennis (wasp) ENSOANP00000019267 Ornithorynchus anatinus (platypus) ENSORLP00000005780 Oryzias latipes (japanese killifish) LOC_Os03g44200.1 Oryza sativa (asian rice) 5989 Ostreococcus tauri (green alga) PHUM002182-PA Pediculus humanus (human body louse) 124820 Physcomitrella patens (moss) ENSPPYP00000009414 Pongo pygmaeus (orangutan) 80430 Phytophthora ramorum (sudden oak death pathogen) 128490 Phytophthora sojae (root rot pathogen) 816633 Populus trichocarpa (black cottonwood) ENSPTRP00000046569 Pan troglodytes (chimpanzee) ENSRNOP00000027868 Rattus norvegicus (norway rat) 5003175 Sorghum bicolor (sorghum) YPL120W Saccharomyces cerevisiae (budding yeast) Smp_048990 Schistosoma mansoni (trematode parasite) SPAC20G8.10c Schizosaccharomyces pombe (fission yeast) XP_786368.2 Strongylocentrotus purpuratus (purple sea urchin) 54385 Trichoplax adhaerens (metazoa) XP_971293.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014523 Tetraodon nigroviridis (green spotted pufferfish) 8428 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034988 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027611 Xenopus tropicalis (frog) YALI0D11968g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42850 modMine - Data generated by the modENCODE project. • FBgn0010709 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15432 LH14136 ISCW014200 FBgn0083333 FBgn0213949 FBgn0201750 FBgn0189857 FBgn0178383 JGI_V11_128719 FBgn0078874 FBgn0161741 FBgn0145686 FBgn0126566 FBgn0104667 FBgn0094984 CPIJ011087 BGIBMGA000092 ACYPI004000 GB14875 AGAP012793 AGAP003858 AAEL010427 PB24583 PHUM420440 GLEAN_09816
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Atg6 (Monserrate et al., 2007, Kadandale et al., 2010, Juhász et al., 2008, Martin et al., 2007, Liu and Lehmann, 2008, Cronin et al., 2009, Kim et al., 2010, Midorikawa et al., 2010, Demontis and Perrimon, 2010) atg6 (Pandey et al., 2007, Pandey et al., 2007, Simonsen et al., 2007, Shelly et al., 2009, Shen and Ganetzky, 2009) ATG6 (Lee et al., 2007, Wu et al., 2009) Beclin-1 (Kadandale et al., 2010) Beclin1 (Lee et al., 2007) CG5429 (Lee et al., 2003, Gorski et al., 2003, Laviolette et al., 2005, Chittaranjan et al., 2009, Perkins et al., 2009, Juhász et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmAtg6 (Chittaranjan et al., 2009) l(3)00096 (Berkeley Drosophila Genome Project, 1993.6.1, Spradling et al., 1999, BDGP Project Members, 1994-1999, )
Name Synonym	Autophagy-specific gene 6 (Scott et al., 2004) Beclin1 (Naps and Neufeld, 2008, Juhász et al., 2008)
Secondary FlyBase IDs
	FBgn0039144
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 3 ) Computer file  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Demontis and Perrimon, 2010, Cell 143(5): 813--825 FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging. [FBrf0212347] Kadandale et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10502--10507 Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. [FBrf0210996] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Midorikawa et al., 2010, J. Neurosci. 30(32): 10703--10719 Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. [FBrf0211516] Show all research papers ...