Gene model reviewed during 5.54
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with nab; which acts as a coactivator. Interacts with ap.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sqz using the Feature Mapper tool.
sqz transcript is expressed in a subset of neurons in the embryonic and first instar larval central nervous system. Scer\GAL4sqz-GAL4-driven expression reveals that this subset is a population of lateral interneurons that primarily project axons in the anterior and posterior commisures of the ventral nerve cord.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sqz in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: sqz anon-WO0118547.697
dsRNA has been made from templates generated with primers directed against this gene. RNAi of sqz causes an increase in the number of class I da neurons. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis but no obvious defects in da dendrite development.
Named "squeeze" because mutant larvae display a motility defect whereby the body wall musculature over-contracts radially during the peristaltic wave typical of larval motility, apparent as a "squeezing" of the intestine.
The gene is named "squeeze" due to a larval motility defect seen in mutants.