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Gene Dmel\unc-45

General Information
Symbol	Dmel\unc-45	Species	D. melanogaster
Name		Annotation symbol	CG2708
Feature type	protein_coding_gene	FlyBase ID	FBgn0010812
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Tom34, dunc-45, DmUnc-45, l(3)03692
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	84E9-84E9	Sequence location	3R:3,859,023..3,862,374 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\unc-45 (CG2708, FBgn0010812). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: chaperone-mediated protein folding; somatic muscle development; myosin filament assembly; cellular response to heat. 9 alleles are reported. The phenotypes of these alleles are annotated with: myofibril; adult heart; embryonic somatic muscle; adult heart chamber 2; adult heart chamber 1. It has one annotated transcript and one annotated polypeptide. Protein features are: Armadillo; Armadillo-like helical; Armadillo-type fold; Tetratricopeptide TPR2; Tetratricopeptide repeat; Tetratricopeptide repeat-containing domain; Tetratricopeptide-like helical; UNC-45/Ring assembly protein 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval salivary gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640009_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tom34. Gene sequence location is 3R:3859023..3862374.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 84E9-84E9   Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930
Experimentally Determined Cytological Location
Cytogenetic map Notes References 84E10-84E11   (determined by in situ hybridisation)   (Spradling et al., 1999) 84E10-84E11   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\unc-45 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) unc-45-RA FBtr0081788  NM_080057   3236   947
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein unc-45-PA   FBpp0081284   105.0   947   5.51     NP_524796   AAF54185
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR2 (IPR013105) Armadillo-like helical (IPR011989) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Armadillo (IPR000225) Armadillo-type fold (IPR016024) Tetratricopeptide repeat (IPR019734) UNC-45/Ring assembly protein 3 (IPR024660)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801533   AA802035   AE014297 AAF54185   AI543541   AQ073315   AY052144 AAK93568   BF495229   BF495519   BG633620   BI238788   BI239754   BI240978   BI573820   BI573821   BI578080   BI630466   BI631991   BI632392   BI639950   BI641100   CL610125   CO185899   CZ478182   EC194696
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VHW4 Q960B1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 11 -- 12   dorsal pharyngeal muscle primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval salivary gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    61.7 Larval Midgut    64.6 Larval Hindgut    68.7 Larval Malpighian Tubules    78.7 Larval Fat Body    41.2 Larval Salivary Gland    230.7 Larval Trachea    89.475 Larval Carcass    129.4 Adult Head    45.9 Adult Eye    46.925 Adult Brain    56.4 Adult Thoracic-Abdominal Ganglion    54 Adult Crop    132.7 Adult Midgut    60.6 Adult Hindgut    70.2 Adult Malpighian Tubules    77.7 Adult Fat Body    17.6 Adult Salivary Gland    40.9 Adult Heart    51.2 Adult VirginFemale Spermatheca    25.5 Adult InseminatedFemale Spermatheca    41.6 Adult Ovary    78 Adult Testis    46.8 Adult Male Accessory Gland    43.3 Adult Carcass    61.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    45.9   NA  Eye    46.925   NA  Brain    56.4   61.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    54   NA  Crop    132.7   64.6  Midgut    60.6   68.7  Hindgut    70.2   78.7  Malpighian Tubules    77.7   41.2  Fat Body    no informative data   230.7  Salivary Gland    no informative data   NA  Heart    51.2   89.475  Trachea    NA   NA  VirginFemale Spermatheca    25.5   NA  InseminatedFemale Spermatheca    41.6   NA  Ovary    78   NA  Testis    46.8   NA  Male Accessory Gland    43.3   129.4  Carcass    61.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae  (32) digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae  32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    10 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    3 head, mated 4-day female    7 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    12 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    8 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    1 fat body, white prepupae    6 fat body, pupae P8    8 carcass, larvae L3 wandering    18 carcass, 1-day adult    14 carcass, 4-day adult    11 carcass, 20-day adult    11 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr    48 embryo 12-14hr    45 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    43 pupae 3d postWPP    66 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr  (48) embryo 12-14hr  (45) embryo 14-16hr  (27) embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP  (43) pupae 3d postWPP  (66) pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr    48 embryo 12-14hr    45 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    43 pupae 3d postWPP    66 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr    48 embryo 12-14hr    45 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    43 pupae 3d postWPP    66 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr    48 embryo 12-14hr    45 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    43 pupae 3d postWPP    66 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr  (48) embryo 12-14hr  (45) embryo 14-16hr  27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP  (43) pupae 3d postWPP  (66) pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr    48 embryo 12-14hr    45 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    43 pupae 3d postWPP    66 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    3 embryo 04-06hr    7 embryo 06-08hr    12 embryo 08-10hr    22 embryo 10-12hr    48 embryo 12-14hr    45 embryo 14-16hr    27 embryo 16-18hr    23 embryo 18-20hr    16 embryo 20-22hr    9 embryo 22-24hr    10 larva L1    13 larva L2    20 larva L3 12hr old    18 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    43 pupae 3d postWPP    66 pupae 4d postWPP    17 adult male 01day    13 adult male 05day    13 adult male 30day    14 adult female 01day    11 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2    40 embryonic Kc167    16 embryonic S1    40 embryonic S3    18 leg disc CME L1    17 wing disc CME-W2    27 wing disc ML-DmD8    28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS    26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2  (40) embryonic Kc167    16 embryonic S1  (40) embryonic S3    18 leg disc CME L1    17 wing disc CME-W2  (27) wing disc ML-DmD8  (28) wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS  26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2    40 embryonic Kc167    16 embryonic S1    40 embryonic S3    18 leg disc CME L1    17 wing disc CME-W2    27 wing disc ML-DmD8    28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS    26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2    40 embryonic Kc167    16 embryonic S1    40 embryonic S3    18 leg disc CME L1    17 wing disc CME-W2    27 wing disc ML-DmD8    28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS    26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2    40 embryonic Kc167    16 embryonic S1    40 embryonic S3    18 leg disc CME L1    17 wing disc CME-W2    27 wing disc ML-DmD8    28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS    26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2  (40) embryonic Kc167    16 embryonic S1  (40) embryonic S3    18 leg disc CME L1    17 wing disc CME-W2  27 wing disc ML-DmD8  28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS  26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2    40 embryonic Kc167    16 embryonic S1    40 embryonic S3    18 leg disc CME L1    17 wing disc CME-W2    27 wing disc ML-DmD8    28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS    26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    17 embryonic 1182-4H    24 embryonic GM2    40 embryonic Kc167    16 embryonic S1    40 embryonic S3    18 leg disc CME L1    17 wing disc CME-W2    27 wing disc ML-DmD8    28 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    21 ovary fGS/OSS    26 ovary OSC    22 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    5 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • PC00405 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010812 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2708-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for unc-45 Stages(s) 1-3 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4how-24B unc-45dsRNA.Scer\UAS.cUa lethal, with Scer\GAL4pnr-MD237 unc-45GD9815 lethal | pupal stage, with Scer\GAL4pnr-MD237 unc-45GD9815 lethal | recessive unc-4503692 lethal | third instar larval stage unc-45EY03034 viable unc-45EY03034 Sterility Allele fertile unc-45EY03034 Other Phenotypes Allele short lived, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa Phenotype manifest in Allele adult heart, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa adult heart, with Scer\GAL4tin.CΔ4, Scer\GAL80ts.αTub84B unc-45dsRNA.Scer\UAS.cUa adult heart chamber 1, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa adult heart chamber 2, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa embryonic/larval heart | P-stage, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa embryonic/larval heart | third instar larval stage, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa embryonic somatic muscle unc-45EY03034-33 myofibril unc-45EY03034-33 myofibril, with Scer\GAL4HCH.Hand unc-45dsRNA.Scer\UAS.cUa
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of unc-45 Class Mutagen Stocks Known lesion unc-4503692 P-element activity 1 -- unc-45e00294 piggyBac transposase 1 -- unc-45EY03034 P-element activity 1 -- unc-45EY03034-33 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of unc-45 Class Mutagen Stocks Known lesion unc-45GD9815 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes unc-45+t in vitro construct - genomic fragment 0 Yes unc-45dsRNA.Scer\UAS.cUa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes unc-45KK101311 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes unc-45NIG.2708R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC222 (Gresens and Cook, 2006.12.5) Df(3R)BSC465 (Christensen et al., 2008.4.15) Df(3R)BSC513 (Christensen et al., 2008.4.15) Df(3R)ED5223 (Roote, 2004.7.20, Ryder and Roote, 2004.11.10) Df(3R)ED5230 (Ryder and Roote, 2004.11.10) Df(3R)Exel6263 (Ryder, 2004.4.26) Df(3R)p712 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)Antp17 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-unc-45.RNAi.U} NA characterization construct P{NIG.2708R} NA P{unc-45+t} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}unc-4503692 No insertion of mobile activating element P{EPgy2}unc-45EY03034 NA miscellaneous insertions PBac{RB}unc-45e00294 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular response to heat inferred from direct assay (Melkani et al., 2010) chaperone-mediated protein folding inferred from direct assay (Melkani et al., 2010) myosin filament assembly inferred from mutant phenotype (Lee et al., 2011) somatic muscle development inferred from mutant phenotype (Lee et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions unc-45 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69376 DroID - A comprehensive database of gene and protein interactions. • FBgn0010812 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44910
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Q85GV Dipteran inclusive ortholog search EOG6XD405 Insect inclusive ortholog search EOG6VT4S4 Arthropod inclusive ortholog search EOG6P5HR2 Metazoa inclusive ortholog search EOG6BS8CF
Orthologs in Drosophila Species (EOG6Q85GV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\unc-45     Drosophila simulans   Dsim\GD19966 Y   Drosophila sechellia   Dsec\GM10996 Y   Drosophila erecta   Dere\GG14374 Y   Drosophila yakuba   Dyak\GE24964 Y   Drosophila ananassae   Dana\GF17806 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15439 Y   Drosophila persimilis   Dper\GL21482 Y   Drosophila willistoni   Dwil\GK13474 Y   Drosophila virilis   Dvir\GJ11067 Y   Drosophila mojavensis   Dmoj\GI10261 Y   Drosophila grimshawi   Dgri\GH17296 Y
Orthologs in non-Drosophila Dipterans (EOG6XD405)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009168   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010948   Anopheles gambiae Malaria mosquito  Agam\AGAP003727   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001395
Orthologs in non-Dipteran Insects (EOG6VT4S4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52008   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012880   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18619   Atta cephalotes Leafcutter ant  Acep\ACEP21174   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15948   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18794   Linepithema humile Argentine ant  Lhum\LH24422   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21686   Solenopsis invicta Red fire ant  Sinv\SINV11608   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009070   Bombyx mori Silkmoth  Bmor\BGIBMGA013146   Pediculus humanus Human body louse  Phum\PHUM240610   Tribolium castaneum Red flour beetle  Tcas\Tom34
Orthologs in non-Insect Arthropods (EOG6P5HR2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\NIA   Daphnia pulex Water flea  Dpux\JGI_V11_302917   Ixodes scapularis Deer tick  Isca\ISCW018499
Orthologs in non-Arthropod Metazoa (EOG6BS8CF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\unc-45   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008927gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001520gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023930gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004079gn   Danio rerio Zebrafish  Drer\unc45a   Danio rerio Zebrafish  Drer\unc45b   Xenopus tropicalis Western clawed frog  Xtro\unc45a   Xenopus tropicalis Western clawed frog  Xtro\unc45b   Gallus gallus Domestic chicken  Ggal\UNC45A   Gallus gallus Domestic chicken  Ggal\UNC45B   Mus musculus House mouse  Mmus\Unc45b   Mus musculus House mouse  Mmus\Unc45a   Rattus norvegicus Norway rat  Rnor\Unc45b   Rattus norvegicus Norway rat  Rnor\Unc45a   Homo sapiens Human  Hsap\UNC45B   Homo sapiens Human  Hsap\UNC45A
Human Orthologs (2)
Gene OMIM HGNC Hsap\UNC45B     Hsap\UNC45A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19966 Drosophila sechellia Dsec\GM10996 Drosophila erecta Dere\GG14374 Drosophila yakuba Dyak\GE24964 Drosophila ananassae Dana\GF17806 Drosophila pseudoobscura pseudoobscura Dpse\GA15439 Drosophila persimilis Dper\GL21482 Drosophila willistoni Dwil\GK13474 Drosophila virilis Dvir\GJ11067 Drosophila mojavensis Dmoj\GI10261 Drosophila grimshawi Dgri\GH17296
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	19664 y1 w67c23; P{EPgy2}unc-45EY03034 11602 P{PZ}unc-4503692 ry506/TM3, ryRK Sb1 Ser1
Harvard	- PBac{RB}unc-45e00294
VDRC	v33560 w1118; P{GD9815}v33560 v33561 w1118; P{GD9815}v33561
Genomic Clones ( 1 )
	BACR07M14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 17 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10334
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04105 AT04461 HL06590 RE36336 RE37947 RE41856 RE71879 RH59514 RH61686 SD22679 SD24266 SD26160
Other clones	CK01.13B.B8 EK014240 GM03758 RH09322
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010812 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44910
Antibody Information
	polyclonal (Lee et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tom34 unc-45 (Checkland, 2002.3.19)
Source for database merge of	Source for merge of: Tom34 CG2708 (Misra, 2000.8.9)
Additional comments
Other Comments
	Embryonic injection of dsRNA made from templates generated with primers directed against this gene results in an entirely normal embryonic muscle pattern. However, these muscles never contract (compared to age-matched controls). (Estrada et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080057 RefSeq (Proteins) • NP_524796 DDBJ / EMBL / GenBank • AA801533 AAF54185 AAK93568 AI543541 AQ073315 AY052144 CL610125 CZ478182 Entrez Gene - A searchable database of RefSeq genes. • 44910 UniProtKB/TrEMBL • Q9VHW4 Q960B1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR2 (IPR013105) Armadillo-like helical (IPR011989) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Armadillo (IPR000225) Armadillo-type fold (IPR016024) Tetratricopeptide repeat (IPR019734) UNC-45/Ring assembly protein 3 (IPR024660) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00405
Linkouts
	BioGRID - A database of protein and genetic interactions • 69376 DroID - A comprehensive database of gene and protein interactions. • FBgn0010812 DRSC - Results from RNAi screens. • FBgn0010812 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010812 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2708-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010812 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44910 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44910 modMine - Data generated by the modENCODE project. • FBgn0010812
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG2708 (Estrada et al., 2006, Keleman et al., 2009.8.5, Melkani et al., 2011, Conrad et al., 2012) DmUnc-45 (Checkland et al., 2002) DmUNC-45 (Lee et al., 2011) dunc-45 (Yu et al., 2005, Melkani et al., 2010, Lee et al., 2011) dUNC-45 (Lee et al., 2011) l(3)03692 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) Tom34 (Gonsalves et al., 2011, Gresens and Cook, 2006.12.5, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Colin et al., 2009, Cronin et al., 2009) unc-45 (Melkani et al., 2011)
Name Synonym	Translocase of outer membrane 34 (Spradling et al., 1999)
Secondary FlyBase IDs
	FBgn0037545
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Conrad et al., 2012, Dev. Cell 22(3): 610--624 The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex. [FBrf0217803] Gonsalves et al., 2011, PLoS ONE 6(1): e15934 Whole-Genome Analysis Reveals That Active Heat Shock Factor Binding Sites Are Mostly Associated with Non-Heat Shock Genes in Drosophila melanogaster. [FBrf0212812] Lee et al., 2011, J. Cell Sci. 124(5): 699--705 Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. [FBrf0212992] Lee et al., 2011, Structure 19(3): 397--408 X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster. [FBrf0213235] Melkani et al., 2011, PLoS ONE 6(7): e22579 The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model. [FBrf0214543] Show all research papers ...