Tom34, dunc-45, l(3)03692, Unc45, lincRNA.721
Gene model reviewed during 5.49
Gene model reviewed during 5.43
Gene model reviewed during 6.03
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\unc-45 using the Feature Mapper tool.
unc-45 protein is detected on western blots at all stages tested. At two hours after egg laying, it localizes to the embryonic blastoderm and co-localizes with non-muscle myosin II. At 14hr AEL, localization is similar to muscle myosin, which is expressed strongly in skeletal muscles such as body-wall muscles and pharyngeal muscle. Weaker staining is observed in gut muscle and in the ectoderm. unc-45 protein was also observed in other skeletal muscles examined including embryonic dorsal tube, adult body-wall muscle, adult dorsal tube, and adult indirect flight muscle.
GBrowse - Visual display of RNA-Seq signalsView Dmel\unc-45 in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Embryonic injection of dsRNA made from templates generated with primers directed against this gene results in an entirely normal embryonic muscle pattern. However, these muscles never contract (compared to age-matched controls).