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Gene Dmel\Gug

General Information
Symbol	Dmel\Gug	Species	D. melanogaster
Name	Grunge	Annotation symbol	CG6964
Feature type	protein_coding_gene	FlyBase ID	FBgn0010825
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	Atro, l(3)03928
Genomic Location
Chromosome (arm)	3L	Recombination map	3-26
Cytogenetic map	66C13-66D1	Sequence location	3L:8,443,022..8,465,769 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Grunge is referred to in FlyBase by the symbol Dmel\Gug (CG6964, FBgn0010825). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone deacetylase activity; repressing transcription factor binding; transcription corepressor activity; DNA binding. There is experimental evidence that it is involved in the biological process: eye development; segment specification; negative regulation of epidermal growth factor receptor signaling pathway; embryonic pattern specification; segmentation; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived leg morphogenesis; negative regulation of transcription, DNA-dependent. 45 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; external compound sense organ; organ system; thoracic segment; adult; cytoplasmic part; organelle; intracellular organelle; peripheral nervous system. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Atrophin-like; ELM2 domain; Homeodomain-like; SANT domain; SANT/Myb domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632497_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Gug. Gene sequence location is 3L:8443022..8465769.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66C13-66D1   Limits computationally determined from genome sequence between P{lacW}l(3)L0139L0139 and P{PZ}Gug03928&P{EP}CG6745EP595b
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66C-66C     (Luschnig et al., 2004) 66D1-66D2     (Zhang, 2002.1.24) 66D-66D     (Erkner, 1999.12.20) 66D1-66D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 66D1-66D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-26 (Erkner et al., 2002)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gug for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone LD10989 appears problematic: incomplete CDS DGC clone LD21589 appears problematic: incomplete CDS DGC clone SD07343 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gug-RA FBtr0076616  NM_145106   8151   1966 Gug-RC FBtr0076618  NM_176300   8217   1988 Gug-RD FBtr0076619  NM_206303   8704   1985 Gug-RE FBtr0305696  NM_001259741   8350   1985 Gug-RF FBtr0305697  NM_001259742   8713   1988 Gug-RG FBtr0305698  NM_001259743   8413   2006 Gug-RH FBtr0305699  NM_079249   8704   1985 Gug-RI FBtr0333048  NM_001274651   8698   1983 Gug-RJ FBtr0333049  NM_001274652   8485   2007
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gug-PA   FBpp0076343   208.2   1966   7.54     NP_659574   AAN12008 Gug-PC   FBpp0076345   210.8   1988   7.50     NP_788478   AAO41268 Gug-PD   FBpp0089427   210.5   1985   7.45     NP_996025   AAS65054 Gug-PE   FBpp0296976   210.5   1985   7.45     NP_001246670   AFH04341 Gug-PF   FBpp0296977   210.9   1988   7.56     NP_001246671   AFH04342 Gug-PG   FBpp0296978   213.0   2006   7.57     NP_001246672   AFH04343 Gug-PH   FBpp0296979   210.4   1985   7.50     NP_523973   AAF50413 Gug-PI   FBpp0305262   210.3   1983   7.61     NP_001261580   AGB94275 Gug-PJ   FBpp0305263   213.1   2007   7.48     NP_001261581   AGB94276
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ELM2 domain (IPR000949) SANT/Myb domain (IPR001005) Atrophin-like (IPR002951) SANT domain (IPR017884) Homeodomain-like (IPR009057)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391897   AA438600   AA440565   AA695184   AA697299   AA698448   AA735592   AA816782   AA990804   AE014296 AAF50413   AE014296 AAN12008   AE014296 AAO41268   AE014296 AAS65054   AF217844 AAF34752   AF475087 AAL78679   AE014296 AFH04341   AE014296 AFH04342   AE014296 AFH04343   AE014296 AGB94275   AE014296 AGB94276   AI455170   AI534489   AW942166   AW944497   AY069476 AAL39621   AY122256 AAM52768   BF487786   BG633587   BG639367   BI564892   BI608895   BI609314   BI610388   BI619948   BI637399   BT025184   CL868624   CO265764   CO268109   CO269246   CO271748   CO272260   CO290337   CO302569   CO320948   CO330352   CO338994   EC067385   EC068236   EC070357   EC084905   EC090278   EC209216   EC210461   EC211683   EC214264   EC224465   EC231564   EC231699   EC232085   EC256666   EC264338   EL884944   EL885068   EL885192   FF579098   G01407   GH959289   GH962528
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KUA8 Q86BH2 Q8IQA6 Q9VSK5 Q8MQW5 Q8T090 Q8T9N4 Q9NHX6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Zhang et al., 2002) polytene chromosome interband inferred from direct assay (Wang et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (630.025) Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    630.025 Larval Midgut    93.1 Larval Hindgut    163.7 Larval Malpighian Tubules    239.1 Larval Fat Body    87.2 Larval Salivary Gland    164.4 Larval Trachea    244.4 Larval Carcass    140.225 Adult Head    139.2 Adult Eye    179.55 Adult Brain    467.9 Adult Thoracic-Abdominal Ganglion    284.2 Adult Crop    229.6 Adult Midgut    168.5 Adult Hindgut    227.7 Adult Malpighian Tubules    329.1 Adult Fat Body    187 Adult Salivary Gland    182.8 Adult Heart    150.7 Adult VirginFemale Spermatheca    240.3 Adult InseminatedFemale Spermatheca    254.1 Adult Ovary    91.3 Adult Testis    31.8 Adult Male Accessory Gland    86.6 Adult Carcass    121.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    139.2   NA  Eye    179.55   NA  Brain    467.9   630.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    284.2   NA  Crop    229.6   93.1  Midgut    168.5   163.7  Hindgut    227.7   239.1  Malpighian Tubules    329.1   87.2  Fat Body    187   164.4  Salivary Gland    182.8   NA  Heart    150.7   244.4  Trachea    NA   NA  VirginFemale Spermatheca    240.3   NA  InseminatedFemale Spermatheca    254.1   NA  Ovary    91.3   NA  Testis    31.8   NA  Male Accessory Gland    86.6   140.225  Carcass    121.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    79 central nervous system, pupae P8    35 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering    31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    70 ovary, mated 4-day female    71 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (79) central nervous system, pupae P8  (35) head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male  26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering  (31) carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female  (70) ovary, mated 4-day female  (71) testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    79 central nervous system, pupae P8    35 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering    31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    70 ovary, mated 4-day female    71 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    79 central nervous system, pupae P8    35 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering    31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    70 ovary, mated 4-day female    71 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    79 central nervous system, pupae P8    35 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering    31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    70 ovary, mated 4-day female    71 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (38) central nervous system, larvae L3  (79) central nervous system, pupae P8  (35) head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male  26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering  31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female  (70) ovary, mated 4-day female  (71) testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    79 central nervous system, pupae P8    35 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering    31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    70 ovary, mated 4-day female    71 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    38 central nervous system, larvae L3    79 central nervous system, pupae P8    35 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    11 head, mated 1-day female    18 head, mated 4-day female    13 head, mated 20-day female    12 head, mated 1-day male    26 head, mated 4-day male    24 head, mated 20-day male    23 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    11 fat body, pupae P8    13 carcass, larvae L3 wandering    31 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    70 ovary, mated 4-day female    71 testis, mated 4-day male    8 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    73 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    47 embryo 10-12hr    32 embryo 12-14hr    36 embryo 14-16hr    40 embryo 16-18hr    30 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (59) embryo 02-04hr  (73) embryo 04-06hr  (55) embryo 06-08hr  (53) embryo 08-10hr  (47) embryo 10-12hr  (32) embryo 12-14hr  (36) embryo 14-16hr  (40) embryo 16-18hr  (30) embryo 18-20hr  (28) embryo 20-22hr  (29) embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr  (27) pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day  (35) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    73 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    47 embryo 10-12hr    32 embryo 12-14hr    36 embryo 14-16hr    40 embryo 16-18hr    30 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    73 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    47 embryo 10-12hr    32 embryo 12-14hr    36 embryo 14-16hr    40 embryo 16-18hr    30 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    35 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    73 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    47 embryo 10-12hr    32 embryo 12-14hr    36 embryo 14-16hr    40 embryo 16-18hr    30 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (59) embryo 02-04hr  (73) embryo 04-06hr  (55) embryo 06-08hr  (53) embryo 08-10hr  (47) embryo 10-12hr  32 embryo 12-14hr  (36) embryo 14-16hr  (40) embryo 16-18hr  30 embryo 18-20hr  28 embryo 20-22hr  29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr  27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day  (35) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    73 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    47 embryo 10-12hr    32 embryo 12-14hr    36 embryo 14-16hr    40 embryo 16-18hr    30 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    73 embryo 04-06hr    55 embryo 06-08hr    53 embryo 08-10hr    47 embryo 10-12hr    32 embryo 12-14hr    36 embryo 14-16hr    40 embryo 16-18hr    30 embryo 18-20hr    28 embryo 20-22hr    29 embryo 22-24hr    24 larva L1    14 larva L2    10 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    16 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    27 pupae 2d postWPP    20 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    14 adult male 30day    12 adult female 01day    23 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    45 ovary OSC    47 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9  (31) wing disc ML-DmD16-c3  (27) wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (31) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS  (45) ovary OSC  (47) ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    45 ovary OSC    47 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    45 ovary OSC    47 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    45 ovary OSC    47 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9  31 wing disc ML-DmD16-c3  27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS  (45) ovary OSC  (47) ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    45 ovary OSC    47 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    18 embryonic GM2    13 embryonic Kc167    10 embryonic S1    18 embryonic S3    16 leg disc CME L1    12 wing disc CME-W2    12 wing disc ML-DmD8    21 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    45 ovary OSC    47 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    60 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (30) cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (60) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (48) Caffeine 25 mg/ml 48 hrs, 4-day adult  (30) Paraquat 5 mM 48 hrs, 4-day adult  (39) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    60 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    60 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    60 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (60) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (48) Caffeine 25 mg/ml 48 hrs, 4-day adult  30 Paraquat 5 mM 48 hrs, 4-day adult  (39) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    60 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    30 cold shock, 4-day adult    23 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    60 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    48 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD10989 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010825 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6964-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Eaat1.PR Gug66QC.Scer\UAS Gug75QN.Scer\UAS lethal, with Scer\GAL4elav.PU Gug75QN.Scer\UAS lethal | embryonic stage Gug35 Gug03928 lethal | embryonic stage | germline clone | maternal effect | recessive Gug3L-22-3 lethal | embryonic stage | germline clone | recessive | rescuable maternal effect Gug3L-22-3 lethal | embryonic stage | maternal effect Gug01323a Gugunspecified lethal | larval stage | recessive Gugj5A3 lethal | partially, with Scer\GAL4mir-8-NP5247 GugEY14339 lethal | partially | heat sensitive, with Scer\GAL4mir-8-NP5247 GugdsRNA.Scer\UAS lethal | recessive Gug3L-22-3 Gug03928 GugEal15 GugEal73 Gugj5A3 GugrO116 GugS2 partially lethal - majority die Gugj5A3 viable GugEY14339 viable, with Scer\GAL4pnr-MD237 GugGD4271 viable (with Gug11) Gug35 viable (with Gug35) Gug11 Sterility Allele fertile GugEY14339 Other Phenotypes Allele cell polarity defective | cell non-autonomous | somatic clone Gugunspecified cell polarity defective | somatic clone Gugunspecified increased cell death | third instar larval stage, with Scer\GAL4mir-8-NP5247 GugEY14339 locomotor behavior defective, with Scer\GAL4mir-8-NP5247 GugEY14339 planar polarity defective (with Gug11) Gug35 planar polarity defective (with Gug35) Gug11 planar polarity defective | somatic clone Gug35 visible, with Scer\GAL4pnr-MD237 GugGD4271 visible | homeotic | recessive | somatic clone Gug1757 visible | recessive | somatic clone Gug35 Gug1757 visible | somatic clone Gug35 Gug3333 Gugunspecified Phenotype manifest in Allele abdominal 2 ventral denticle belt | germline clone | maternal effect Gug3L-22-3 abdominal 4 ventral denticle belt | germline clone | maternal effect Gug3L-22-3 abdominal 5 ventral denticle belt | germline clone | maternal effect Gug3L-22-3 abdominal 6 ventral denticle belt | germline clone | maternal effect Gug3L-22-3 abdominal 8 ventral denticle belt | germline clone | maternal effect Gug3L-22-3 adult abdominal segment 5 | somatic clone Gug1757 adult abdominal segment 6 | somatic clone Gug1757 adult thorax | somatic clone Gug35 arista | somatic clone Gug35 GugEal15 arista lateral | somatic clone GugEal15 autophagic vacuole, with Scer\GAL4GMR.PU GugScer\UAS.cCa Gug75QN.Scer\UAS Gug66QC.Scer\UAS bract | ectopic | somatic clone Gug35 cone cell | somatic clone | supernumerary Gug35 coxa | somatic clone Gug35 denticle belt | germline clone Gugunspecified egg | germline clone | maternal effect Gug1757 embryo | germline clone | maternal effect Gug1757 embryonic/first instar larval cuticle | germline clone Gugunspecified embryonic/first instar larval cuticle | rescuable maternal effect | ventral Gug35 embryonic/first instar larval cuticle | ventral Guga.cEa embryonic/larval brain, with Scer\GAL4mir-8-NP5247 GugEY14339 embryonic/larval neuron | ectopic | germline clone Gugunspecified embryonic abdomen | germline clone | maternal effect Gug3L-22-3 embryonic epidermis | germline clone Gugunspecified embryonic head Gug35 embryonic segment Guga.cEa embryonic segment | germline clone | maternal effect Gug3L-22-3 embryonic segment | germline clone | non-rescuable maternal effect Gug3333 Gug519 embryonic segment | non-rescuable maternal effect Gug35 eye, with Scer\GAL4GMR.PU Gug75QN.Scer\UAS Gug66QC.Scer\UAS eye, with Scer\GAL4ninaE.PT GugScer\UAS.cCa Gug75QN.Scer\UAS Gug66QC.Scer\UAS eye | somatic clone Gugunspecified eye photoreceptor cell, with Scer\GAL4GMR.PU GugScer\UAS.cCa eye photoreceptor cell, with Scer\GAL4ninaE.PT GugScer\UAS.cCa Gug75QN.Scer\UAS Gug66QC.Scer\UAS eye photoreceptor cell | drug conditional, with Scer\GAL4GMR.PU Gug75QN.Scer\UAS eye photoreceptor cell | somatic clone Gug35 Gugunspecified femur | proximal | somatic clone Gug35 interommatidial bristle, with Scer\GAL4GMR.PF GugScer\UAS.cCa leg, with Scer\GAL4mir-8-NP5247 GugEY14339 leg | cell non-autonomous | somatic clone | ventral Gug1757 leg | somatic clone GugEal15 leg | somatic clone | ventral Gug35 leg sensillum & prothoracic femur | somatic clone Gug35 leg sensillum | cell non-autonomous | somatic clone Gug35 leg sensillum | somatic clone Gug35 mesothoracic tarsal bristle | somatic clone Gug35 mesothoracic tergum, with Scer\GAL4pnr-MD237 GugGD4271 mesothoracic tergum | somatic clone Gugunspecified mesothoracic tibial apical bristle | somatic clone Gug35 metathoracic tarsal bristle | somatic clone Gug35 mitochondrion, with Scer\GAL4GMR.PU GugScer\UAS.cCa ocellar triangle | somatic clone Gug35 ommatidium, with Scer\GAL4GMR.PF GugScer\UAS.cCa ommatidium (with Gug11) Gug35 ommatidium (with Gug35) Gug11 ommatidium | cell non-autonomous | somatic clone Gug35 ommatidium | somatic clone Gug35 Gugunspecified prothoracic tarsal bristle | somatic clone Gug35 prothoracic tibial apical bristle | somatic clone Gug35 prothoracic tibial transverse row bristle | somatic clone Gug35 retina | temperature conditional, with Scer\GAL4GMR.PU GugScer\UAS.cCa Gug75QN.Scer\UAS Gug66QC.Scer\UAS rhabdomere | somatic clone Gugunspecified sex comb | somatic clone Gug35 tarsal segment, with Scer\GAL4dpp.blk1 GugScer\UAS.cCa trichome of the posterior wing margin | somatic clone Gug35 triple row | somatic clone Gug35 trochanter | somatic clone Gug35 unguis | somatic clone Gug35 GugEal15 wing, with Scer\GAL4C-580 GugScer\UAS.cCa wing, with Scer\GAL4mir-8-NP5247 GugEY14339 wing | somatic clone Gug35 wing hair | cell non-autonomous | somatic clone Gugunspecified wing margin | somatic clone Gugunspecified wing vein GugUbi-p63E.T:Avic\GFP wing vein, with Scer\GAL4C-580 GugScer\UAS.cCa wing vein | cell autonomous | somatic clone | supernumerary Gug35 wing vein | ectopic, with Scer\GAL4dpp.blk1 GugdsRNA.1.Scer\UAS GugdsRNA.2.Scer\UAS wing vein | ectopic | somatic clone Gug3333 Gugunspecified wing vein | somatic clone Gug3333 wing vein | somatic clone | supernumerary Gug14967
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of Gug Class Mutagen Stocks Known lesion Gug02836b 1 -- Gug03928 P-element activity 1 Yes Gug04069a 1 -- GugAGiR gene conversion Delta2-3 1 Yes GugEY14339 P-element activity 1 -- GugKG01280 1 -- GugNP1598 1 -- GugNP2517 1 -- GugNP3609 1 -- GugNP5315 1 -- Gug01323a P-element activity 0 Yes Gug11 0 -- Gug1207D6 0 -- Gug14967 P-element activity 0 Yes Gug1757 ethyl methanesulfonate 0 -- Gug2295 ethyl methanesulfonate 0 -- Gug3333 ethyl methanesulfonate 0 -- Gug35 Delta2-3 0 Yes Gug3L-22-3 ethyl methanesulfonate 0 -- Gug519 ethyl methanesulfonate 0 -- Guge46-2 P-element activity 0 Yes Guge46-3 P-element activity 0 Yes GugEal15 0 -- GugEal73 0 -- GugGX8261 Delta2-3 0 -- Gugj5A3 P-element activity 0 -- GugrO116 P-element activity 0 -- GugrO154a P-element activity 0 -- GugS146907 0 -- GugS2 ethyl methanesulfonate 0 -- Gugunspecified 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gug Class Mutagen Stocks Known lesion GugGD4271 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GugHMS00756 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GugKK100675 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gug66QC.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Gug75QN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Guga.cEa in vitro construct 0 Yes GugcEa in vitro construct 0 Yes GugdsRNA.1.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GugdsRNA.2.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GugdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Gughs.PZ in vitro construct - regulatory fusion 0 Yes GugScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes GugScer\UAS.cXa in vitro construct - regulatory fusion 0 Yes GugUbi-p63E.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC13 (Deal and Cook, 2002.2.25) Df(3L)BSC157 (Gresens and Cook, 2006.5.11) Df(3L)BSC389 (Christensen et al., 2007.10.29) Df(3L)BSC815 (Christensen et al., 2009.6.15) Df(3L)h-i22 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(3L)h-i22 (Spradling et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4271} NA P{KK100675} NA P{TRiP.HMS00756} NA P{UAS-Atro.66QC} NA P{UAS-Atro.75QN} NA P{UAS-Atro.C} NA P{UAS-Atro.X} NA P{UAS-Gug.RNAi} NA characterization construct P{Ubi-Atro.GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Gug14967 No P{lacW}Gugj5A3 No P{lacW}GugS146907 No P{PZ}Gug01323a No P{PZ}Gug02836b No P{PZ}Gug03928 No P{PZ}Gug04069a No P{PZ}GugrO116 No P{PZ}GugrO154a No insertion of mobile activating element P{EP}GugGX8261 NA P{EPgy2}GugEY14339 NA P{GSV1}GSd216GSd216 NA P{GSV1}GSd410GSd410 NA P{GSV1}GSd479GSd479 NA insertion of enhancer trap binary system P{GAL4}GugAGiR No P{GawB}GugNP1598 No P{GawB}GugNP2517 No P{GawB}GugNP3609 No P{GawB}GugNP5315 No miscellaneous insertions P{SUPor-P}GugKG01280 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Wang et al., 2006) histone deacetylase activity inferred from direct assay (Wang et al., 2006) repressing transcription factor binding inferred from physical interaction with eve (Zhang et al., 2002) inferred from physical interaction with hkb (Zhang et al., 2002) transcription corepressor activity inferred from direct assay (Zhang et al., 2002) inferred from genetic interaction with eve (Zhang et al., 2002)
Biological Process
CV term Evidence References
embryonic pattern specification inferred from mutant phenotype (Zhang et al., 2002) eye development inferred from mutant phenotype (Charroux et al., 2006) imaginal disc-derived leg morphogenesis inferred from mutant phenotype (Erkner et al., 2002) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Wang et al., 2008, Charroux et al., 2006) negative regulation of epidermal growth factor receptor signaling pathway inferred from genetic interaction with aos (Charroux et al., 2006) inferred from genetic interaction with rho (Charroux et al., 2006) inferred from genetic interaction with rl (Charroux et al., 2006) negative regulation of transcription, DNA-dependent inferred from direct assay (Zhang et al., 2002) segmentation inferred from mutant phenotype (Zhang et al., 2002) segment specification inferred from mutant phenotype (Luschnig et al., 2004)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Zhang et al., 2002) polytene chromosome interband inferred from direct assay (Wang et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from electronic annotation with InterPro:IPR001005 (FlyBase Curators et al., 2004-) transcription corepressor activity non-traceable author statement (Zhang, 2002.1.24)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gug allele Gene References Gug519 Antp (Kankel et al., 2004) ftz (Kankel et al., 2004) Pcl (Kankel et al., 2004) Scr (Kankel et al., 2004) trx (Kankel et al., 2004) Gug01323a eve (Zhang et al., 2002) hkb (Zhang et al., 2002) Gug1757 Antp (Kankel et al., 2004) ftz (Kankel et al., 2004) Pcl (Kankel et al., 2004) Scr (Kankel et al., 2004) trx (Kankel et al., 2004) Ubx (Kankel et al., 2004) Gug2295 ftz (Kankel et al., 2004) Scr (Kankel et al., 2004) trx (Kankel et al., 2004) Gug3333 Antp (Kankel et al., 2004) ftz (Kankel et al., 2004) Pcl (Kankel et al., 2004) Scr (Kankel et al., 2004) trx (Kankel et al., 2004) Gug03928 eve (Zhang et al., 2002) Guge46-2 eve (Zhang et al., 2002) hkb (Zhang et al., 2002) GugrO154a eve (Zhang et al., 2002) GugS2 w (Erkner et al., 2002) unspecified al (Wehn and Campbell, 2006) aop (Charroux et al., 2006) aos (Charroux et al., 2006) brm (Kankel et al., 2004) gro (Wehn and Campbell, 2006) mir-8 (Karres et al., 2007) pnt (Charroux et al., 2006) rho (Charroux et al., 2006) rl (Charroux et al., 2006) sbb (Wehn and Campbell, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70115 DroID - A comprehensive database of gene and protein interactions. • FBgn0010825 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46156
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZW5XV Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6ZW5XV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gug     Drosophila simulans   Dsim\GD14095 Y   Drosophila erecta   Dere\GG14314 Y   Drosophila yakuba   Dyak\GE20743 Y   Drosophila ananassae   Dana\GF24326 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19989 Y   Drosophila persimilis   Dper\GL15500 Y   Drosophila willistoni   Dwil\GK20351 Y   Drosophila virilis   Dvir\GJ20491     Drosophila virilis   Dvir\GJ13040 Y   Drosophila mojavensis   Dmoj\GI12899 Y   Drosophila grimshawi   Dgri\GH15305 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14095 Drosophila sechellia Dsec\GM25056 Drosophila erecta Dere\GG14314 Drosophila yakuba Dyak\GE20743 Drosophila ananassae Dana\GF24326 Drosophila pseudoobscura pseudoobscura Dpse\GA19989 Drosophila persimilis Dper\GL15500 Drosophila willistoni Dwil\GK20351 Drosophila virilis Dvir\GJ13040 Drosophila mojavensis Dmoj\GI12899 Drosophila grimshawi Dgri\GH15305
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	6773 w*; P{GAL4}GugAGiR/TM6B, Tb1 20800 y1 w67c23; P{EPgy2}GugEY14339 32961 y1 sc* v1; P{TRiP.HMS00756}attP2 13419 y1 w67c23; P{SUPor-P}GugKG01280 ry506 11615 P{PZ}Gug03928 ry506/TM3, ryRK Sb1 Ser1 11213 cn1 P{PZ}l(2)02836a02836a/CyO; P{PZ}Gug02836b ry506
Kyoto	113676 w*; P{GawB}GugNP5315 / TM6, P{UAS-lacZ.UW23-1}UW23-1 104556 w*; P{GawB}GugNP3609 / TM6, Sb1 Tb1 112948 w*; P{GawB}GugNP2517 / TM3, Sb1 Ser1 112723 y* w*; P{GawB}GugNP1598 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v107413 P{KK100675}VIE-260B v13687 w1118; P{GD4271}v13687/TM3
Availability	Atrophin (Wang et al., 2006)
	More stocks available...
Genomic Clones ( 1 )
	BACR13D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP16051 LD21589 SD07343
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT22841 HL02216 HL04588 LD10344 LD12916 LD15383 LD34693 LP06283 RH13613 RH14078 RH15825 RH51089 RH62463 SD19407
Other clones	8154 36649 42887 59571 76841 118487 191260 191607 214381.76 569689 Arica_10_G04 CK01.94C.H11 CK01.113C.A2 CK01.118D.G6 CK01.123B.E12 CK01.168A.D9 EK073730 EK090159 EK093950 EK104511 EK106457 EK143603 EK184447 EK289106 EK295031 EP00561 GM02370 IP16151 IP16251 IP16351 LD10989 RP004005241 RP004522759
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010825 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46156
Antibody Information
	polyclonal (Wang et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gug Atro (O'Farrell, 2002.4.27) Source for merge of: Gug CG6964 (Bayraktaroglu, 2000.8.7) Source for merge of: l(3)03928 l(3)01323 (Beaton, 1999.12.12)
Additional comments
Other Comments
	Gug is a direct target of mir-8. (Karres et al., 2007) Gug acts downstream or in parallel to rl. (Charroux et al., 2006) Gug is crucial for correct segmentation during embryogenesis. (Erkner et al., 2002) Gug is required in diverse developmental processes including early embryo patterning. (Zhang et al., 2002) Identification: Modifies tsh expression in imaginal disc. (Erkner et al., 1997) Gug is required for patterning of the ventral proximal leg; in mutant cells proximal patterns are replaced with more distal ones. Gug is also required in all ventrally located cells along the entire proximal-distal axis of the leg for specific ventral identities or processes. (Erkner et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079249 NM_145106 NM_176300 NM_206303 NM_001259741 NM_001259742 NM_001259743 NM_001274651 NM_001274652 RefSeq (Proteins) • NP_523973 NP_659574 NP_788478 NP_996025 NP_001246670 NP_001246671 NP_001246672 NP_001261580 NP_001261581 DDBJ / EMBL / GenBank • AA391897 AA440565 AA735592 AAF34752 AAF50413 AAL39621 AAL78679 AAM52768 AAN12008 AAO41268 AAS65054 AF217844 AF475087 AFH04341 AFH04342 AFH04343 AGB94275 AGB94276 AI455170 AI534489 AW942166 AW944497 AY069476 AY122256 CL868624 G01407 Entrez Gene - A searchable database of RefSeq genes. • 46156 UniProtKB/TrEMBL • Q7KUA8 Q8IQA6 Q8MQW5 Q8T9N4 Q8T090 Q9NHX6 Q9VSK5 Q86BH2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ELM2 domain (IPR000949) SANT/Myb domain (IPR001005) Atrophin-like (IPR002951) SANT domain (IPR017884) Homeodomain-like (IPR009057) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD10989
Linkouts
	BioGRID - A database of protein and genetic interactions • 70115 DroID - A comprehensive database of gene and protein interactions. • FBgn0010825 DRSC - Results from RNAi screens. • FBgn0010825 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010825 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6964-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010825 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 351111 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46156 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/grunge1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46156 modMine - Data generated by the modENCODE project. • FBgn0010825
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	Atro (Kankel et al., 2004, Zhang, 2002.1.24, Zhang et al., 2002, Wehn and Campbell, 2006, Wang et al., 2006, Charroux et al., 2006, Haecker et al., 2007, Fanto and McNeill, 2004, Fanto et al., 2003, Wang et al., 2008, Nisoli et al., 2010) atro (Luschnig et al., 2004, Strutt, 2003, Parkhurst and Delidakis, 2003, Strutt and Strutt, 2005, Arbouzova and McNeill, 2007, Karres et al., 2007, Hyun et al., 2009, Baena-Lopez et al., 2008, Li et al., 2009) CG6964 (Pilot et al., 2006, Karres et al., 2007, Keleman et al., 2009.8.5, Raker et al., 2009, Ni et al., 2010.12.1) gug (Cho and Irvine, 2004, Luschnig et al., 2004, Luschnig et al., 2004, Tyler et al., 2007, Link et al., 2007, Paik et al., 2012) Gug (Christensen et al., 2007.10.29, Minidorff et al., 2007, Martin et al., 2007, Christensen et al., 2009.6.15, Raker et al., 2009) GUG (Tsai and Wang, 2007) l(3)01323 (Nicholls and Gelbart, 1998, ) l(3)03928 (Misra, 2000.8.25, Beaton, 1999.12.12, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(3)j5A3   l(3)rO116   l(3)S146907 (Link et al., 2007) unnamed (Gibson et al., 2002)
Name Synonym	Atrophin (Nisoli et al., 2005, Fanto et al., 2003, Fujioka et al., 2003, Charroux et al., 2005, Zhang et al., 2002, Wehn and Campbell, 2006, Wang et al., 2006, Charroux et al., 2006, Charroux et al., 2007, Fanto and McNeill, 2004, Fanto et al., 2003, Haecker et al., 2007, Wang et al., 2008, Raker et al., 2009) atrophin (Riley, 2006, Tyler et al., 2007, Strutt and Strutt, 2005, Karres et al., 2007, Hyun et al., 2009, Sopko et al., 2009, Li et al., 2009, Vallejo et al., 2011) Grunge (Erkner et al., 1997, Wang and Tsai, 2007, Martin et al., 2007, Raker et al., 2009) grunge (Aldaz et al., 2010, Link et al., 2007, Link et al., 2007)
Secondary FlyBase IDs
	FBgn0011373 FBgn0011523 FBgn0020427 FBgn0024868 FBgn0035897
References ( 83 )
Generate a list of	All references relating to this gene ( 83 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 8 ) Review  ( 6 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245 Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] Napoletano et al., 2011, EMBO J. 30(5): 945--958 Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. [FBrf0213147] Vallejo et al., 2011, EMBO J. 30(4): 756--769 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. [FBrf0213063] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...