FB2021_03, released June 15, 2021

Gene: Dmel\Gug

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General Information
Symbol
Dmel\Gug
Species
D. melanogaster
Name
Grunge
Annotation Symbol
CG6964
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010825
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
Grunge (Gug) encodes a nuclear repressor protein that likely responds to Egfr signaling to control cell behavior for normal developmental patterning. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Atro, Atrophin, l(3)03928, l(3)01323

Key Links
Genomic Location
Cytogenetic map
66C13-66D1
Sequence location
3L:8,449,922..8,472,669 [+]
Recombination map
3-24
RefSeq locus
NT_037436 REGION:8449922..8472669
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor binding
inferred from physical interaction with FLYBASE:eve; FB:FBgn0000606
(Zhang et al., 2002)
inferred from physical interaction with FLYBASE:hkb; FB:FBgn0261434
(Zhang et al., 2002)
enables nuclear receptor binding
inferred from physical interaction with FLYBASE:tll; FB:FBgn0003720
(Wang et al., 2006)
enables transcription corepressor activity
inferred from direct assay
(Wang et al., 2006, Zhang et al., 2002)
inferred from genetic interaction with FLYBASE:eve; FB:FBgn0000606
(Zhang et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables RNA polymerase II-specific DNA-binding transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN001015306
(assigned by GO_Central )
(Gaudet et al., 2011)
enables transcription corepressor activity
inferred from biological aspect of ancestor with PANTHER:PTN001015306
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in embryonic pattern specification
inferred from mutant phenotype
(Zhang et al., 2002)
involved_in eye development
inferred from mutant phenotype
(Charroux et al., 2006)
involved_in imaginal disc-derived leg morphogenesis
inferred from mutant phenotype
(Erkner et al., 2002)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Wang et al., 2008, Charroux et al., 2006)
involved_in inter-male aggressive behavior
inferred from mutant phenotype
(Davis et al., 2014)
involved_in larval somatic muscle development
inferred from expression pattern
(Dobi et al., 2014)
inferred from mutant phenotype
(Dobi et al., 2014)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:rl; FB:FBgn0003256
(Charroux et al., 2006)
inferred from genetic interaction with FLYBASE:aos; FB:FBgn0004569
(Charroux et al., 2006)
inferred from genetic interaction with FLYBASE:rho; FB:FBgn0004635
(Charroux et al., 2006)
involved_in negative regulation of smoothened signaling pathway
inferred from mutant phenotype
(Zhang et al., 2013)
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Zhang et al., 2013)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Wang et al., 2006)
involved_in negative regulation of transcription, DNA-templated
inferred from direct assay
(Zhang et al., 2013, Zhang et al., 2002)
involved_in regulation of histone acetylation
inferred from mutant phenotype
(Zhang et al., 2013)
involved_in segment specification
inferred from high throughput mutant phenotype
(Luschnig et al., 2004)
involved_in segmentation
inferred from mutant phenotype
(Zhang et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Zhang et al., 2002)
located_in polytene chromosome interband
inferred from direct assay
(Wang et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001015306
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Grunge (Gug) encodes a nuclear repressor protein that likely responds to Egfr signaling to control cell behavior for normal developmental patterning. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
SANT-MYB DOMAIN TRANSCRIPTION REGULATORS -
The SANT-MYB domain transcription regulators are essentially part of chromatin remodelling complexes and co-repressors. The SANT domain shows similarity with DNA-binding helix-turn-helix of Myb domain, and are involved in protein-protein interactions in the chromatin complexes. (Adapted from PMID:15040448).
Pathway (FlyBase)
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Summary (Interactive Fly)

transcriptional cofactor for Even-skipped - positive regulator of - homolog of mammalian Atrophin

Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
8

Please see the JBrowse view of Dmel\Gug for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gug-RA
FBtr0076616
NM_145106
8151
1966
Gug-RC
FBtr0076618
NM_176300
8217
1988
Gug-RD
FBtr0076619
NM_206303
8704
1985
Gug-RE
FBtr0305696
NM_001259741
8350
1985
Gug-RF
FBtr0305697
NM_001259742
8713
1988
Gug-RG
FBtr0305698
NM_001259743
8413
2006
Gug-RH
FBtr0305699
NM_079249
8704
1985
Gug-RI
FBtr0333048
NM_001274651
8698
1983
Gug-RJ
FBtr0333049
NM_001274652
8485
2007
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Gug-PA
FBpp0076343
208.2
1966
7.54
NP_659574
AAN12008
Gug-PC
FBpp0076345
210.8
1988
7.50
NP_788478
AAO41268
Gug-PD
FBpp0089427
210.5
1985
7.45
NP_996025
AAS65054
Gug-PE
FBpp0296976
210.5
1985
7.45
NP_001246670
AFH04341
Gug-PF
FBpp0296977
210.9
1988
7.56
NP_001246671
AFH04342
Gug-PG
FBpp0296978
213.0
2006
7.57
NP_001246672
AFH04343
Gug-PH
FBpp0296979
210.4
1985
7.50
NP_523973
AAF50413
Gug-PI
FBpp0305262
210.3
1983
7.61
NP_001261580
AGB94275
Gug-PJ
FBpp0305263
213.1
2007
7.48
NP_001261581
AGB94276
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1985 aa isoforms: Gug-PD, Gug-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gug using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Zhang et al., 2002)
Additional Descriptive Data

Gug transcript is detected at all stages of embryogenesis.

(Zhang et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- larval stage
organism | ubiquitous
(Zhang et al., 2002)
embryonic stage 5
organism | ubiquitous
• nucleus
(Zhang et al., 2002)
embryonic stage 15 -- third instar larval stage
embryonic/larval central nervous system
(Zhang et al., 2002)
larval stage
imaginal disc
(Zhang et al., 2002)
third instar larval stage
embryonic/larval optic lobe
• nucleus
(Zhang et al., 2002)
adult stage
cell body rind region
(Davis et al., 2014)
Additional Descriptive Data

In early embryos, Gug protein is ubiquitously expressed in all cells, where it is localized to the nucleus. In later embryos, Gug protein expression is at a higher level in the CNS. Gug protein is detected in all larval tissues, including imaginal discs, the brain, and the optic lobes.

(Zhang et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Zhang et al., 2002)
located_in polytene chromosome interband
inferred from direct assay
(Wang et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gug in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 32 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gug
Transgenic constructs containing regulatory region of Gug
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Eaat1.PR
lethal, with Scer\GAL4elav.PU
lethal, with Scer\GAL4elav-C155
lethal | embryonic stage | germline clone | recessive | rescuable maternal effect
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die during embryonic stage
lethal - all die during embryonic stage | germline clone | maternal effect | recessive
lethal - all die during embryonic stage | maternal effect
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal, with Scer\GAL4NP5247
partially lethal | heat sensitive, with Scer\GAL4NP5247
partially lethal - majority die
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Gug11)
viable (with Gug35)
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal behavior | male limited, with Scer\GAL4elav-C155
abnormal cell adhesion | oogenesis, with Scer\GAL4slbo.2.6
abnormal cell migration | oogenesis | oogenesis, with Scer\GAL4slbo.2.6
abnormal cell polarity | cell non-autonomous | somatic clone
abnormal cell polarity | somatic clone
abnormal locomotor behavior, with Scer\GAL4NP5247
abnormal neuroanatomy | progressive, with Scer\GAL4GMR.PF
abnormal planar polarity (with Gug11)
abnormal planar polarity (with Gug35)
abnormal planar polarity | somatic clone
flightless, with Scer\GAL4Mef2.PR
increased cell death | third instar larval stage, with Scer\GAL4NP5247
some die during embryonic stage
some die during embryonic stage | maternal effect
some die during embryonic stage | maternal effect | recessive
some die during larval stage | recessive
some die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
visible, with Scer\GAL4pnr-MD237
visible | homeotic | recessive | somatic clone
visible | recessive | somatic clone
visible | somatic clone
Phenotype manifest in
Allele
abdominal 2 ventral denticle belt | germline clone | maternal effect
abdominal 4 ventral denticle belt | germline clone | maternal effect
abdominal 5 ventral denticle belt | germline clone | maternal effect
abdominal 6 ventral denticle belt | germline clone | maternal effect
abdominal 8 ventral denticle belt | germline clone | maternal effect
adult abdominal segment 5 | somatic clone
adult abdominal segment 6 | somatic clone
adult thorax | somatic clone
arista | somatic clone
arista lateral | somatic clone
autophagosome, with Scer\GAL4GMR.PU
autophagosome | increased number, with Scer\GAL4ninaE.PT
border follicle cell, with Scer\GAL4slbo.2.6
bract | ectopic | somatic clone
cone cell | somatic clone | increased number
coxa | somatic clone
denticle belt | germline clone
egg | germline clone | maternal effect
embryo | germline clone | maternal effect
embryonic/first instar larval cuticle | germline clone
embryonic/first instar larval cuticle | rescuable maternal effect | ventral
embryonic/larval brain, with Scer\GAL4NP5247
embryonic/larval neuron | ectopic | germline clone
embryonic/larval somatic muscle
embryonic/larval somatic muscle (with Df(3L)BSC389)
embryonic abdomen | germline clone | maternal effect
embryonic epidermis | germline clone
embryonic head
embryonic segment | germline clone | maternal effect
embryonic segment | germline clone | non-rescuable maternal effect
embryonic segment | non-rescuable maternal effect
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4ninaE.PT
eye | somatic clone
eye photoreceptor cell, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4ninaE.PT
eye photoreceptor cell | drug conditional, with Scer\GAL4GMR.PU
eye photoreceptor cell | progressive, with Scer\GAL4GMR.PF
eye photoreceptor cell | somatic clone
femur | proximal | somatic clone
interommatidial bristle, with Scer\GAL4GMR.PF
leg, with Scer\GAL4NP5247
leg | cell non-autonomous | somatic clone | ventral
leg | somatic clone
leg | somatic clone | ventral
leg sensillum & prothoracic femur | somatic clone
leg sensillum | cell non-autonomous | somatic clone
leg sensillum | somatic clone
mesothoracic tarsal bristle | somatic clone
mesothoracic tergum, with Scer\GAL4pnr-MD237
mesothoracic tergum | somatic clone
mesothoracic tibial apical bristle | somatic clone
metathoracic tarsal bristle | somatic clone
mitochondrion, with Scer\GAL4GMR.PU
ocellar triangle | somatic clone
ommatidium, with Scer\GAL4GMR.PF
ommatidium (with Gug11)
ommatidium (with Gug35)
ommatidium | cell non-autonomous | somatic clone
ommatidium | somatic clone
prothoracic tarsal bristle | somatic clone
prothoracic tibial apical bristle | somatic clone
prothoracic tibial transverse row bristle | somatic clone
retina | temperature conditional, with Scer\GAL4GMR.PU
rhabdomere | somatic clone
sex comb | somatic clone
tarsal segment, with Scer\GAL4dpp.blk1
trichome of the posterior wing margin | somatic clone
triple row | somatic clone
trochanter | somatic clone
unguis | somatic clone
wing, with Scer\GAL4C-580
wing, with Scer\GAL4NP5247
wing | somatic clone
wing hair | cell non-autonomous | somatic clone
wing margin | somatic clone
wing vein
wing vein, with Scer\GAL4C-580
wing vein | cell autonomous | somatic clone | increased number
wing vein | ectopic, with Scer\GAL4dpp.blk1
wing vein | ectopic | somatic clone
wing vein | somatic clone
wing vein | somatic clone | increased number
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RERE
10 of 15
Yes
Yes
Hsap\ATN1
7 of 15
No
Yes
6  
Hsap\MTA1
1 of 15
No
No
Hsap\MTA2
1 of 15
No
No
Hsap\MTA3
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rere
10 of 15
Yes
Yes
Mmus\Atn1
7 of 15
No
Yes
Mmus\Mta1
1 of 15
No
No
Mmus\Mta2
1 of 15
No
No
Mmus\Mta3
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Rere
6 of 13
Yes
Yes
Rnor\Atn1
4 of 13
No
Yes
Rnor\LOC100911672
2 of 13
No
Yes
Rnor\Mta1
1 of 13
No
No
Rnor\Mta2
1 of 13
No
No
Rnor\Mta3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\rere
3 of 12
Yes
Yes
Xtro\atn1
2 of 12
No
Yes
Xtro\mta1
1 of 12
No
No
Xtro\mta2
1 of 12
No
No
Danio rerio (Zebrafish) (6)
Drer\rerea
9 of 15
Yes
Yes
Drer\rereb
8 of 15
No
Yes
Drer\atn1
3 of 15
No
Yes
Drer\mta1
1 of 15
No
No
Drer\mta2
1 of 15
No
No
Drer\mta3
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\egl-27
7 of 15
Yes
Yes
Cele\pqn-20
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\AT1G09040
1 of 9
Yes
Yes
Atha\AT1G09050
1 of 9
Yes
Yes
Atha\AT1G55050
1 of 9
Yes
Yes
Atha\AT2G47820
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900TW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003742
Drosophila simulans
Dsim\GD14095
Drosophila sechellia
Dsec\GM25056
Drosophila erecta
Dere\GG14314
Drosophila yakuba
Dyak\GE20743
Drosophila ananassae
Dana\GF24326
Drosophila pseudoobscura pseudoobscura
Dpse\GA19989
Drosophila persimilis
Dper\GL15500
Drosophila willistoni
Dwil\GK20351
Drosophila virilis
Dvir\GJ13040
Drosophila mojavensis
Dmoj\GI12899
Drosophila grimshawi
Dgri\GH15305
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502NT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010559
Glossina morsitans
Tsetse fly
Gmor\GMOY005375
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05437
Mayetiola destructor
Hessian fly
Mdes\Mdes002608
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08MB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\3043009700
Apis mellifera
Western honey bee
Amel\GB54092
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11151
Bombus terrestris
Buff-tailed bumblebee
Bter\15208976
Linepithema humile
Argentine ant
Lhum\LH22841
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0031ad
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006681
Pediculus humanus
Human body louse
Phum\PHUM418040
Rhodnius prolixus
Kissing bug
Rpro\RPRC015233
Rhodnius prolixus
Kissing bug
Rpro\RPRC015203
Cimex lectularius
Bed bug
Clec\CLEC009756
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009485
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07500
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EZS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011833
Strigamia maritima
European centipede
Smar\SMAR015539
Ixodes scapularis
Black-legged tick
Isca\ISCW023589
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59729.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g05340
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59449
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0O1H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rere
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_002979gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023596
Gallus gallus
Domestic chicken
Ggal\ATN1
Gallus gallus
Domestic chicken
Ggal\RERE
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
MTA1-like
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
ATN1; atrophin 1
model of  dentatorubral-pallidoluysian atrophy
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
Gug75QN.UAS
model of  dentatorubral-pallidoluysian atrophy
is exacerbated by Atg1GS10797
(Nisoli et al., 2010)
is exacerbated by TorTED.UAS
(Nisoli et al., 2010)
is exacerbated by ft8
(Napoletano et al., 2011)
is exacerbated by ftG-rv
(Napoletano et al., 2011)
is exacerbated by sav3
(Napoletano et al., 2011)
is ameliorated by wtsG4808
(Napoletano et al., 2011)
is ameliorated by dGC13
(Napoletano et al., 2011)
Gug66QC.UAS
model of  dentatorubral-pallidoluysian atrophy
is exacerbated by Atg1GS10797
(Nisoli et al., 2010)
is exacerbated by TorTED.UAS
(Nisoli et al., 2010)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RERE; arginine-glutamic acid dipeptide repeats
10 of 15
605226
    ATN1; atrophin 1
    7 of 15
    607462
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Gug
    enhanceable
    aop
    (Charroux et al., 2006)
    Gug
    enhanceable
    Atg1
    (Nisoli et al., 2010)
    Gug
    enhanceable
    Atg5
    (Nisoli et al., 2010)
    Gug
    suppressible
    d
    (Napoletano et al., 2011)
    Gug
    suppressible
    DnaJ-1
    (Nisoli et al., 2010)
    Gug
    enhanceable
    eve
    (Zhang et al., 2002)
    Gug
    enhanceable
    ft
    (Napoletano et al., 2011)
    Gug
    enhanceable
    hkb
    (Zhang et al., 2002)
    Gug
    enhanceable
    pnt
    (Charroux et al., 2006)
    Gug
    enhanceable
    sav
    (Napoletano et al., 2011)
    Gug
    enhanceable
    Tor
    (Nisoli et al., 2010)
    Gug
    suppressible
    wts
    (Napoletano et al., 2011)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    al
    enhanceable
    Gug
    (Wehn and Campbell, 2006)
    Antp
    suppressible
    Gug
    (Kankel et al., 2004)
    aop
    enhanceable
    Gug
    (Charroux et al., 2006)
    aos
    enhanceable
    Gug
    (Charroux et al., 2006)
    aos
    suppressible
    Gug
    (Charroux et al., 2006)
    btl::Egfr
    suppressible
    Gug|aop
    (Charroux et al., 2006)
    ft
    enhanceable
    Gug
    (Fanto et al., 2003)
    ftz
    enhanceable
    Gug
    (Kankel et al., 2004)
    mir-8
    suppressible
    Gug
    (Karres et al., 2007)
    Pcl
    suppressible
    Gug
    (Kankel et al., 2004)
    rho
    enhanceable
    Gug
    (Charroux et al., 2006)
    rho
    suppressible
    Gug
    (Charroux et al., 2006)
    rl
    enhanceable
    Gug
    (Charroux et al., 2006)
    rl
    suppressible
    Gug
    (Charroux et al., 2006)
    Scr
    suppressible
    Gug
    (Kankel et al., 2004)
    trx
    enhanceable
    Gug
    (Kankel et al., 2004)
    Ubx
    enhanceable
    Gug
    (Kankel et al., 2004)
    w
    enhanceable
    Gug
    (Erkner et al., 2002)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Negative Regulators of EGFR Signaling Pathway -
    Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
    Negative Regulators of Hedgehog Signaling Pathway -
    Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-24
    Cytogenetic map
    66C13-66D1
    Sequence location
    3L:8,449,922..8,472,669 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    66C13-66D1
    Limits computationally determined from genome sequence between P{lacW}l(3)L0139L0139 and P{PZ}Gug03928&P{EP}CG6745EP595b
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    66C-66C
    (Luschnig et al., 2004)
    66D1-66D2
    (Zhang, 2002.1.24, BDGP Project Members, 1994-1999)
    66D-66D
    (Erkner, 1999.12.20)
    66D1-66D2
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    Experimentally Determined Recombination Data
    Location

    3-24

    (FlyBase, 2016)

    3-19.7

    (Comeron et al., 2012)

    3-26

    (Erkner et al., 2002)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (44)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Wang et al., 2008)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: l(3)03928 l(3)01323

      (Beaton, 1999.12.12)

      Source for merge of: Gug CG6964

      (Bayraktaroglu, 2000.8.7)

      Source for merge of: Gug Atro

      (O'Farrell, 2002.4.27)
      Additional comments
      Other Comments

      Gug is a direct target of mir-8.

      (Karres et al., 2007)

      Gug acts downstream or in parallel to rl.

      (Charroux et al., 2006)

      Gug is crucial for correct segmentation during embryogenesis.

      (Erkner et al., 2002)

      Gug is required in diverse developmental processes including early embryo patterning.

      (Zhang et al., 2002)

      Identification: Modifies tsh expression in imaginal disc.

      (Erkner et al., 1997)

      Gug is required for patterning of the ventral proximal leg; in mutant cells proximal patterns are replaced with more distal ones. Gug is also required in all ventrally located cells along the entire proximal-distal axis of the leg for specific ventral identities or processes.

      (Erkner et al., 1997)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 86 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB
      EMBL-EBI Single Cell Expression Atlas
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (15)
      Reported As
      Symbol Synonym
      Atro
      (Bhattacharjee et al., 2019, Kacsoh et al., 2017, Yeung et al., 2017, Xiong et al., 2015, Xu et al., 2015, Alkhori et al., 2014, Davis et al., 2014, Mannervik, 2014, Sing et al., 2014, Zhang et al., 2013, Napoletano et al., 2011, McNeill, 2010, Nisoli et al., 2010, Wang et al., 2008, Haecker et al., 2007, Charroux et al., 2006, Wang et al., 2006, Wehn and Campbell, 2006, Fanto and McNeill, 2004, Kankel et al., 2004, Fanto et al., 2003, Zhang, 2002.1.24, Zhang et al., 2002)
      CG6964
      (Guven-Ozkan et al., 2016, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Raker et al., 2009, Karres et al., 2007, Pilot et al., 2006)
      GUG
      (Tsai and Wang, 2007)
      Gug
      (Hagen et al., 2021, Das and Bhadra, 2020, Chai et al., 2019, Raza et al., 2019, Gene Disruption Project members, 2018-, Levis, 2018.8.30, Kacsoh et al., 2017, Rohde et al., 2017, Selvan et al., 2017, Guven-Ozkan et al., 2016, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Thomas et al., 2015, Ashwal-Fluss et al., 2014, Davis et al., 2014, Dobi et al., 2014, Housden et al., 2014, Rogers et al., 2014, Sadeqzadeh et al., 2014, Christensen et al., 2009.6.15, Raker et al., 2009, Christensen et al., 2007.10.29, Martin et al., 2007, Minidorff et al., 2007)
      atro
      (Arbouzova et al., 2019, Robin et al., 2019, Sharma and McNeill, 2013, Singh and Mlodzik, 2012, Bao et al., 2011, Hyun et al., 2009, Li et al., 2009, Baena-Lopez et al., 2008, Arbouzova and McNeill, 2007, Karres et al., 2007, Strutt and Strutt, 2005, Luschnig et al., 2004, Parkhurst and Delidakis, 2003, Strutt, 2003)
      gug
      (Robin et al., 2019, Paik et al., 2012, Link et al., 2007, Tyler et al., 2007, Cho and Irvine, 2004, Luschnig et al., 2004, Luschnig et al., 2004)
      l(3)01323
      (Nicholls and Gelbart, 1998)
      l(3)03928
      (Misra, 2000.8.25, Beaton, 1999.12.12, Spradling et al., 1999, BDGP Project Members, 1994-1999)
      l(3)S146907
      (Link et al., 2007)
      l(3)j5A3
      l(3)rO116
      Name Synonyms
      Atrophin
      (Nässel and Vanden Broeck, 2016, Thomas et al., 2015, Alkhori et al., 2014, Davis et al., 2014, Sadeqzadeh et al., 2014, Sharma and McNeill, 2013, Zhang et al., 2013, Singh and Mlodzik, 2012, Bao et al., 2011, Raker et al., 2009, Wang et al., 2008, Charroux et al., 2007, Haecker et al., 2007, Charroux et al., 2006, Wang et al., 2006, Wehn and Campbell, 2006, Charroux et al., 2005, Nisoli et al., 2005, Fanto and McNeill, 2004, Fanto et al., 2003, Fanto et al., 2003, Fujioka et al., 2003, Zhang et al., 2002)
      Grunge
      (Thomas et al., 2015, Xiong et al., 2015, Xu et al., 2015, Alkhori et al., 2014, Housden et al., 2014, Sadeqzadeh et al., 2014, Zhang et al., 2013, Williams et al., 2012, Raker et al., 2009, Martin et al., 2007, Wang and Tsai, 2007, Erkner et al., 1997)
      atrophin
      (Lucas et al., 2015, Mulakkal et al., 2014, Vallejo et al., 2011, Hyun et al., 2009, Li et al., 2009, Sopko et al., 2009, Karres et al., 2007, Tyler et al., 2007, Riley, 2006, Strutt and Strutt, 2005)
      grunge
      (Aldaz et al., 2010, Link et al., 2007, Link et al., 2007)
      Secondary FlyBase IDs
      • FBgn0011373
      • FBgn0011523
      • FBgn0020427
      • FBgn0024868
      • FBgn0035897
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (135)