38E.16, l(2)k07135
Please see the JBrowse view of Dmel\dia for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
4.8, 4.4 (northern blot)
1091 (aa); 123 (kD predicted)
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dia using the Feature Mapper tool.
dia transcript is expressed predominantly in tubular organs, including trachea, salivary glands, Malpighian tubules, the hindgut and the proventriculus, starting at embryonic stage 14. Transcript is localized to the apical side, facing the tube lumen.
dia transcripts are expressed in both males and females and are not germline specific.
dia protein localizes mainly to the M lines in the indirect flight muscle sarcomere 1 day after eclosion and then sifts to the Z disc as the sarcomers stop growing.
dia protein is apically localized in tubular organs.
dia protein is found pre- and postsynaptically at the third instar larval neuromuscular junction.
GBrowse - Visual display of RNA-Seq signals
View Dmel\dia in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: dia CG1768
Source for merge of: dia l(2)k07135
null alleles lethal.
dia is required for generation of apical F-actin in diverse types of epithelial tubes in the embryo.
dia is required for furrow canal formation during cellularisation.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
dia has a role in actin cytoskeleton organisation.
dia function is required for cytokinesis.
Proliferation defect locus.