A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\shk

General Information
SymbolDmel\shkSpeciesD. melanogaster
NameshankAnnotation symbol
Feature typegeneFlyBase IDFBgn0011210
Gene Model StatusUnannotated Stock availability 1 publicly available
Also Known Asms(3)07735
Genomic Location
Chromosome (arm)Recombination map3-[47.1]
Cytogenetic map82C1-82C5Sequence location
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Automatically generated summary

See sections below for more information
The gene shank is referred to in FlyBase by the symbol Dmel\shk (FBgn0011210). It is a gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: male meiosis; spermatogenesis. One allele is reported. The phenotypes of this allele are annotated with: Nebenkern; spermatid. It has no annotated transcripts. Gene has not been localized to the genome sequence.

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Description
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
82C1-82C5  
Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
82C1-82C5  
(determined by in situ hybridisation)  
(Spradling et al., 1999)
82C1-82C5  
 
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
3-[47.1]
 
Left of (cM)
Right of (cM)
Notes
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Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
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hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
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Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Sterility
Allele
male sterile
male sterile | recessive
Other Phenotypes
Allele
meiotic cell cycle defective
Phenotype manifest in
Allele
Nebenkern
spermatid
hide Classical Alleles ( 1 )
For All Classical Alleles Show

Allele of shkClassMutagenStocksKnown lesion
shk11 --
hide Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show

Allele of shkClassMutagenStocksKnown lesion
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Disrupted in
(Colas et al., 1999)
(Colas et al., 1999)
(Colas et al., 1999)
(Colas et al., 1999)
(Castrillon et al., 1993)
Not disrupted in
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap
P{PZ}shk1
No
hide Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
hide Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
Evidence
References
male meiosis
inferred from mutant phenotype
(Castrillon et al., 1993)
spermatogenesis
inferred from mutant phenotype
(Castrillon et al., 1993)
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 0 terms )
hide Sequence Ontology: Class of Gene
gene
 
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Protein-protein
Interacting group
Assay
References
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Interacts with
Please look at the allele data for full details of the genetic interactions
shk allele
Gene
References
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Linkouts
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
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hide Stocks Listed in FlyBase ( 1 )
Bloomington
11796
P{PZ}shk1 ry506/TM3, ryRK Sb1 Ser1
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cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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Source for database identity of
Source for database merge of
Additional comments
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Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.
(Braun et al., 1997)
Meiotic division defect.
(Castrillon et al., 1993)
hide External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym
ms(3)07735
(Colas et al., 1999, Braun et al., 1997, Schaerlinger et al., 2007)
shk
 
Name Synonym
shank
 
Secondary FlyBase IDs
hide References ( 10 )
Research paper
Schaerlinger et al., 2007, Dev. Dynamics 236(4): 991--999
Gain of affinity point mutation in the serotonin receptor gene 5-HT(2Dro) accelerates germband extension movements during Drosophila gastrulation. [FBrf0194099]
Colas et al., 1999, Mech. Dev. 87(1-2): 77--91
Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. [FBrf0111346]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Braun et al., 1997, Genetics 147(2): 623--634
Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. [FBrf0098749]
Castrillon et al., 1993, Genetics 135(2): 489--505
Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. [FBrf0064394]
Review
Fuller, 1993, Bate, Martinez Arias, 1993: 71--147
Spermatogenesis. [FBrf0064778]
Personal communication to FlyBase
Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington.
lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
Abstract
Hime et al., 1996, A. Dros. Res. Conf. 37: 60
Ring canal assembly in male meiosis. [FBrf0085218]
Hime et al., 1994, A. Dros. Res. Conf. 35: 49
Actin morphogenesis and cytokinesis in male meiosis. [FBrf0067790]
Computer file
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]