General Information Symbol Dmel\ blwSpecies D. melanogaster Name bellwether Annotation symbol CG3612 Feature type protein_coding_gene FlyBase ID FBgn0011211 Gene Model Status Current Stock availability 14 publicly
available Also Known As A2(2nd)27, ATPsyn-α Genomic Location Chromosome (arm) 2R Recombination map Cytogenetic map 59B1-59B2 Sequence location 2R:18,686,561..18,689,685 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
bellwether is referred to in FlyBase by the symbol
Dmel\blw (CG3612, FBgn0011211). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : hydrogen-exporting ATPase activity, phosphorylative mechanism. There is experimental evidence that it is involved in the
biological process : growth; spermatid development; phagocytosis, engulfment.
31 alleles are reported . The
phenotype of these alleles is annotated with: mesothoracic tergum. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: ATPase, F1 complex, alpha subunit; ATPase, F1/A1 complex, alpha subunit, N-terminal; ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal; ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, alpha/beta subunit, N-terminal; ATPase, alpha/beta subunit, nucleotide-binding domain, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636548_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of blw. Gene sequence location is
2R:18686561..18689685 .
User Contributed Data
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FB2013_03
FB2013_02
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
59B1-59B2
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
- A database of annotated Dmel nuclear genes encoding mitochondrial proteins
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. regulatory region
evidence=Reporter construct (in vitro)
regulatory region
evidence=Reporter construct (in vitro)
External Data Linkouts Crossreferences Expression Data Transcript Expression
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
2259.5
Larval Midgut
4692.7
Larval Hindgut
4737.5
Larval Malpighian Tubules
2775.5
Larval Fat Body
2042.1
Larval Salivary Gland
3974.6
Larval Trachea
2527.175
Larval Carcass
4540.975
Adult Head
3463.2
Adult Eye
3443.875
Adult Brain
2769.9
Adult Thoracic-Abdominal Ganglion
3719.1
Adult Crop
4047.2
Adult Midgut
3516.3
Adult Hindgut
4630.1
Adult Malpighian Tubules
5474.3
Adult Fat Body
5347.4
Adult Salivary Gland
9013.2
Adult Heart
4228.6
Adult VirginFemale Spermatheca
6418.5
Adult InseminatedFemale Spermatheca
6445.3
Adult Ovary
2346.9
Adult Testis
811.6
Adult Male Accessory Gland
3364.1
Adult Carcass
6129.4
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(2259.5)
Larval Midgut
(4692.7)
Larval Hindgut
(4737.5)
Larval Malpighian Tubules
(2775.5)
Larval Fat Body
(2042.1)
Larval Salivary Gland
(3974.6)
Larval Trachea
(2527.175)
Larval Carcass
(4540.975)
Adult Head
(3463.2)
Adult Eye
(3443.875)
Adult Brain
(2769.9)
Adult Thoracic-Abdominal Ganglion
(3719.1)
Adult Crop
(4047.2)
Adult Midgut
(3516.3)
Adult Hindgut
(4630.1)
Adult Malpighian Tubules
(5474.3)
Adult Fat Body
(5347.4)
Adult Salivary Gland
(9013.2)
Adult Heart
(4228.6)
Adult VirginFemale Spermatheca
(6418.5)
Adult InseminatedFemale Spermatheca
(6445.3)
Adult Ovary
(2346.9)
Adult Testis
(811.6)
Adult Male Accessory Gland
(3364.1)
Adult Carcass
(6129.4)
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
(2259.5)
Larval Midgut
(4692.7)
Larval Hindgut
(4737.5)
Larval Malpighian Tubules
(2775.5)
Larval Fat Body
(2042.1)
Larval Salivary Gland
(3974.6)
Larval Trachea
(2527.175)
Larval Carcass
(4540.975)
Adult Head
(3463.2)
Adult Eye
(3443.875)
Adult Brain
(2769.9)
Adult Thoracic-Abdominal Ganglion
(3719.1)
Adult Crop
(4047.2)
Adult Midgut
(3516.3)
Adult Hindgut
(4630.1)
Adult Malpighian Tubules
(5474.3)
Adult Fat Body
(5347.4)
Adult Salivary Gland
(9013.2)
Adult Heart
(4228.6)
Adult VirginFemale Spermatheca
(6418.5)
Adult InseminatedFemale Spermatheca
(6445.3)
Adult Ovary
(2346.9)
Adult Testis
811.6
Adult Male Accessory Gland
(3364.1)
Adult Carcass
(6129.4)
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
2259.5
Larval Midgut
4692.7
Larval Hindgut
4737.5
Larval Malpighian Tubules
2775.5
Larval Fat Body
2042.1
Larval Salivary Gland
3974.6
Larval Trachea
2527.175
Larval Carcass
4540.975
Adult Head
3463.2
Adult Eye
3443.875
Adult Brain
2769.9
Adult Thoracic-Abdominal Ganglion
3719.1
Adult Crop
4047.2
Adult Midgut
3516.3
Adult Hindgut
4630.1
Adult Malpighian Tubules
5474.3
Adult Fat Body
5347.4
Adult Salivary Gland
9013.2
Adult Heart
4228.6
Adult VirginFemale Spermatheca
6418.5
Adult InseminatedFemale Spermatheca
6445.3
Adult Ovary
2346.9
Adult Testis
811.6
Adult Male Accessory Gland
3364.1
Adult Carcass
6129.4
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
2259.5
Larval Midgut
4692.7
Larval Hindgut
4737.5
Larval Malpighian Tubules
2775.5
Larval Fat Body
2042.1
Larval Salivary Gland
3974.6
Larval Trachea
2527.175
Larval Carcass
4540.975
Adult Head
3463.2
Adult Eye
3443.875
Adult Brain
2769.9
Adult Thoracic-Abdominal Ganglion
3719.1
Adult Crop
4047.2
Adult Midgut
3516.3
Adult Hindgut
4630.1
Adult Malpighian Tubules
5474.3
Adult Fat Body
5347.4
Adult Salivary Gland
9013.2
Adult Heart
4228.6
Adult VirginFemale Spermatheca
6418.5
Adult InseminatedFemale Spermatheca
6445.3
Adult Ovary
2346.9
Adult Testis
811.6
Adult Male Accessory Gland
3364.1
Adult Carcass
6129.4
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(2259.5)
Larval Midgut
(4692.7)
Larval Hindgut
(4737.5)
Larval Malpighian Tubules
(2775.5)
Larval Fat Body
(2042.1)
Larval Salivary Gland
(3974.6)
Larval Trachea
(2527.175)
Larval Carcass
(4540.975)
Adult Head
(3463.2)
Adult Eye
(3443.875)
Adult Brain
(2769.9)
Adult Thoracic-Abdominal Ganglion
(3719.1)
Adult Crop
(4047.2)
Adult Midgut
(3516.3)
Adult Hindgut
(4630.1)
Adult Malpighian Tubules
(5474.3)
Adult Fat Body
(5347.4)
Adult Salivary Gland
(9013.2)
Adult Heart
(4228.6)
Adult VirginFemale Spermatheca
(6418.5)
Adult InseminatedFemale Spermatheca
(6445.3)
Adult Ovary
(2346.9)
Adult Testis
811.6
Adult Male Accessory Gland
(3364.1)
Adult Carcass
(6129.4)
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
(2259.5)
Larval Midgut
(4692.7)
Larval Hindgut
(4737.5)
Larval Malpighian Tubules
(2775.5)
Larval Fat Body
(2042.1)
Larval Salivary Gland
(3974.6)
Larval Trachea
(2527.175)
Larval Carcass
(4540.975)
Adult Head
(3463.2)
Adult Eye
(3443.875)
Adult Brain
(2769.9)
Adult Thoracic-Abdominal Ganglion
(3719.1)
Adult Crop
(4047.2)
Adult Midgut
(3516.3)
Adult Hindgut
(4630.1)
Adult Malpighian Tubules
(5474.3)
Adult Fat Body
(5347.4)
Adult Salivary Gland
(9013.2)
Adult Heart
(4228.6)
Adult VirginFemale Spermatheca
(6418.5)
Adult InseminatedFemale Spermatheca
(6445.3)
Adult Ovary
(2346.9)
Adult Testis
811.6
Adult Male Accessory Gland
(3364.1)
Adult Carcass
(6129.4)
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
2259.5
Larval Midgut
4692.7
Larval Hindgut
4737.5
Larval Malpighian Tubules
2775.5
Larval Fat Body
2042.1
Larval Salivary Gland
3974.6
Larval Trachea
2527.175
Larval Carcass
4540.975
Adult Head
3463.2
Adult Eye
3443.875
Adult Brain
2769.9
Adult Thoracic-Abdominal Ganglion
3719.1
Adult Crop
4047.2
Adult Midgut
3516.3
Adult Hindgut
4630.1
Adult Malpighian Tubules
5474.3
Adult Fat Body
5347.4
Adult Salivary Gland
9013.2
Adult Heart
4228.6
Adult VirginFemale Spermatheca
6418.5
Adult InseminatedFemale Spermatheca
6445.3
Adult Ovary
2346.9
Adult Testis
811.6
Adult Male Accessory Gland
3364.1
Adult Carcass
6129.4
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
3463.2
NA
Eye
3443.875
NA
Brain
2769.9
2259.5
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
3719.1
NA
Crop
4047.2
4692.7
Midgut
3516.3
4737.5
Hindgut
4630.1
2775.5
Malpighian Tubules
5474.3
2042.1
Fat Body
5347.4
3974.6
Salivary Gland
9013.2
NA
Heart
4228.6
2527.175
Trachea
NA
NA
VirginFemale Spermatheca
6418.5
NA
InseminatedFemale Spermatheca
6445.3
NA
Ovary
2346.9
NA
Testis
811.6
NA
Male Accessory Gland
3364.1
4540.975
Carcass
6129.4
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
260
central nervous system, larvae L3
129
central nervous system, pupae P8
154
head, virgin 1-day female
569
head, virgin 4-day female
235
head, virgin 20-day female
281
head, mated 1-day female
394
head, mated 4-day female
157
head, mated 20-day female
227
head, mated 1-day male
596
head, mated 4-day male
215
head, mated 20-day male
182
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
73
digestive system, 1-day adult
249
digestive system, 4-day adult
179
digestive system, 20-day adult
208
fat body, larvae L3 wandering
69
fat body, white prepupae
43
fat body, pupae P8
73
carcass, larvae L3 wandering
117
carcass, 1-day adult
1158
carcass, 4-day adult
349
carcass, 20-day adult
244
ovary, virgin 4-day female
239
ovary, mated 4-day female
211
testis, mated 4-day male
51
accessory gland, mated 4-day male
84
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(260)
central nervous system, larvae L3
(129)
central nervous system, pupae P8
(154)
head, virgin 1-day female
(569)
head, virgin 4-day female
(235)
head, virgin 20-day female
(281)
head, mated 1-day female
(394)
head, mated 4-day female
(157)
head, mated 20-day female
(227)
head, mated 1-day male
(596)
head, mated 4-day male
(215)
head, mated 20-day male
(182)
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
(73)
digestive system, 1-day adult
(249)
digestive system, 4-day adult
(179)
digestive system, 20-day adult
(208)
fat body, larvae L3 wandering
(69)
fat body, white prepupae
(43)
fat body, pupae P8
(73)
carcass, larvae L3 wandering
(117)
carcass, 1-day adult
(1158)
carcass, 4-day adult
(349)
carcass, 20-day adult
(244)
ovary, virgin 4-day female
(239)
ovary, mated 4-day female
(211)
testis, mated 4-day male
(51)
accessory gland, mated 4-day male
(84)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(260)
central nervous system, larvae L3
(129)
central nervous system, pupae P8
(154)
head, virgin 1-day female
(569)
head, virgin 4-day female
(235)
head, virgin 20-day female
(281)
head, mated 1-day female
(394)
head, mated 4-day female
(157)
head, mated 20-day female
(227)
head, mated 1-day male
(596)
head, mated 4-day male
(215)
head, mated 20-day male
(182)
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
73
digestive system, 1-day adult
(249)
digestive system, 4-day adult
(179)
digestive system, 20-day adult
(208)
fat body, larvae L3 wandering
69
fat body, white prepupae
43
fat body, pupae P8
73
carcass, larvae L3 wandering
(117)
carcass, 1-day adult
(1158)
carcass, 4-day adult
(349)
carcass, 20-day adult
(244)
ovary, virgin 4-day female
(239)
ovary, mated 4-day female
(211)
testis, mated 4-day male
51
accessory gland, mated 4-day male
84
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
260
central nervous system, larvae L3
129
central nervous system, pupae P8
154
head, virgin 1-day female
569
head, virgin 4-day female
235
head, virgin 20-day female
281
head, mated 1-day female
394
head, mated 4-day female
157
head, mated 20-day female
227
head, mated 1-day male
596
head, mated 4-day male
215
head, mated 20-day male
182
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
73
digestive system, 1-day adult
249
digestive system, 4-day adult
179
digestive system, 20-day adult
208
fat body, larvae L3 wandering
69
fat body, white prepupae
43
fat body, pupae P8
73
carcass, larvae L3 wandering
117
carcass, 1-day adult
1158
carcass, 4-day adult
349
carcass, 20-day adult
244
ovary, virgin 4-day female
239
ovary, mated 4-day female
211
testis, mated 4-day male
51
accessory gland, mated 4-day male
84
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
260
central nervous system, larvae L3
129
central nervous system, pupae P8
154
head, virgin 1-day female
569
head, virgin 4-day female
235
head, virgin 20-day female
281
head, mated 1-day female
394
head, mated 4-day female
157
head, mated 20-day female
227
head, mated 1-day male
596
head, mated 4-day male
215
head, mated 20-day male
182
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
73
digestive system, 1-day adult
249
digestive system, 4-day adult
179
digestive system, 20-day adult
208
fat body, larvae L3 wandering
69
fat body, white prepupae
43
fat body, pupae P8
73
carcass, larvae L3 wandering
117
carcass, 1-day adult
1158
carcass, 4-day adult
349
carcass, 20-day adult
244
ovary, virgin 4-day female
239
ovary, mated 4-day female
211
testis, mated 4-day male
51
accessory gland, mated 4-day male
84
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(260)
central nervous system, larvae L3
(129)
central nervous system, pupae P8
(154)
head, virgin 1-day female
(569)
head, virgin 4-day female
(235)
head, virgin 20-day female
(281)
head, mated 1-day female
(394)
head, mated 4-day female
(157)
head, mated 20-day female
(227)
head, mated 1-day male
(596)
head, mated 4-day male
(215)
head, mated 20-day male
(182)
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
(73)
digestive system, 1-day adult
(249)
digestive system, 4-day adult
(179)
digestive system, 20-day adult
(208)
fat body, larvae L3 wandering
(69)
fat body, white prepupae
(43)
fat body, pupae P8
(73)
carcass, larvae L3 wandering
(117)
carcass, 1-day adult
(1158)
carcass, 4-day adult
(349)
carcass, 20-day adult
(244)
ovary, virgin 4-day female
(239)
ovary, mated 4-day female
(211)
testis, mated 4-day male
(51)
accessory gland, mated 4-day male
(84)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(260)
central nervous system, larvae L3
129
central nervous system, pupae P8
(154)
head, virgin 1-day female
(569)
head, virgin 4-day female
(235)
head, virgin 20-day female
(281)
head, mated 1-day female
(394)
head, mated 4-day female
(157)
head, mated 20-day female
(227)
head, mated 1-day male
(596)
head, mated 4-day male
(215)
head, mated 20-day male
(182)
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
73
digestive system, 1-day adult
(249)
digestive system, 4-day adult
(179)
digestive system, 20-day adult
(208)
fat body, larvae L3 wandering
69
fat body, white prepupae
43
fat body, pupae P8
73
carcass, larvae L3 wandering
117
carcass, 1-day adult
(1158)
carcass, 4-day adult
(349)
carcass, 20-day adult
(244)
ovary, virgin 4-day female
(239)
ovary, mated 4-day female
(211)
testis, mated 4-day male
51
accessory gland, mated 4-day male
84
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
260
central nervous system, larvae L3
129
central nervous system, pupae P8
154
head, virgin 1-day female
569
head, virgin 4-day female
235
head, virgin 20-day female
281
head, mated 1-day female
394
head, mated 4-day female
157
head, mated 20-day female
227
head, mated 1-day male
596
head, mated 4-day male
215
head, mated 20-day male
182
salivary gland, larvae L3 wandering
8
salivary gland, white prepupae
20
digestive system, larvae L3 wandering
73
digestive system, 1-day adult
249
digestive system, 4-day adult
179
digestive system, 20-day adult
208
fat body, larvae L3 wandering
69
fat body, white prepupae
43
fat body, pupae P8
73
carcass, larvae L3 wandering
117
carcass, 1-day adult
1158
carcass, 4-day adult
349
carcass, 20-day adult
244
ovary, virgin 4-day female
239
ovary, mated 4-day female
211
testis, mated 4-day male
51
accessory gland, mated 4-day male
84
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
741
embryo 02-04hr
376
embryo 04-06hr
206
embryo 06-08hr
273
embryo 08-10hr
336
embryo 10-12hr
535
embryo 12-14hr
488
embryo 14-16hr
1095
embryo 16-18hr
1147
embryo 18-20hr
1420
embryo 20-22hr
1570
embryo 22-24hr
1338
larva L1
2350
larva L2
2175
larva L3 12hr old
2185
larva L3 puffstage 1-2
761
larva L3 puffstage 3-6
422
larva L3 puffstage 7-9
289
white prepupae new
287
white prepupae 12hr
259
white prepupae 24hr
318
pupae 2d postWPP
620
pupae 3d postWPP
2061
pupae 4d postWPP
3724
adult male 01day
2975
adult male 05day
1588
adult male 30day
837
adult female 01day
3223
adult female 05day
970
adult female 30day
818
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(741)
embryo 02-04hr
(376)
embryo 04-06hr
(206)
embryo 06-08hr
(273)
embryo 08-10hr
(336)
embryo 10-12hr
(535)
embryo 12-14hr
(488)
embryo 14-16hr
(1095)
embryo 16-18hr
(1147)
embryo 18-20hr
(1420)
embryo 20-22hr
(1570)
embryo 22-24hr
(1338)
larva L1
(2350)
larva L2
(2175)
larva L3 12hr old
(2185)
larva L3 puffstage 1-2
(761)
larva L3 puffstage 3-6
(422)
larva L3 puffstage 7-9
(289)
white prepupae new
(287)
white prepupae 12hr
(259)
white prepupae 24hr
(318)
pupae 2d postWPP
(620)
pupae 3d postWPP
(2061)
pupae 4d postWPP
(3724)
adult male 01day
(2975)
adult male 05day
(1588)
adult male 30day
(837)
adult female 01day
(3223)
adult female 05day
(970)
adult female 30day
(818)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(741)
embryo 02-04hr
(376)
embryo 04-06hr
(206)
embryo 06-08hr
(273)
embryo 08-10hr
(336)
embryo 10-12hr
(535)
embryo 12-14hr
(488)
embryo 14-16hr
(1095)
embryo 16-18hr
(1147)
embryo 18-20hr
(1420)
embryo 20-22hr
(1570)
embryo 22-24hr
(1338)
larva L1
(2350)
larva L2
(2175)
larva L3 12hr old
(2185)
larva L3 puffstage 1-2
(761)
larva L3 puffstage 3-6
(422)
larva L3 puffstage 7-9
(289)
white prepupae new
(287)
white prepupae 12hr
(259)
white prepupae 24hr
(318)
pupae 2d postWPP
(620)
pupae 3d postWPP
(2061)
pupae 4d postWPP
(3724)
adult male 01day
(2975)
adult male 05day
(1588)
adult male 30day
(837)
adult female 01day
(3223)
adult female 05day
(970)
adult female 30day
(818)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
741
embryo 02-04hr
376
embryo 04-06hr
206
embryo 06-08hr
273
embryo 08-10hr
336
embryo 10-12hr
535
embryo 12-14hr
488
embryo 14-16hr
1095
embryo 16-18hr
1147
embryo 18-20hr
1420
embryo 20-22hr
1570
embryo 22-24hr
1338
larva L1
2350
larva L2
2175
larva L3 12hr old
2185
larva L3 puffstage 1-2
761
larva L3 puffstage 3-6
422
larva L3 puffstage 7-9
289
white prepupae new
287
white prepupae 12hr
259
white prepupae 24hr
318
pupae 2d postWPP
620
pupae 3d postWPP
2061
pupae 4d postWPP
3724
adult male 01day
2975
adult male 05day
1588
adult male 30day
837
adult female 01day
3223
adult female 05day
970
adult female 30day
818
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
741
embryo 02-04hr
376
embryo 04-06hr
206
embryo 06-08hr
273
embryo 08-10hr
336
embryo 10-12hr
535
embryo 12-14hr
488
embryo 14-16hr
1095
embryo 16-18hr
1147
embryo 18-20hr
1420
embryo 20-22hr
1570
embryo 22-24hr
1338
larva L1
2350
larva L2
2175
larva L3 12hr old
2185
larva L3 puffstage 1-2
761
larva L3 puffstage 3-6
422
larva L3 puffstage 7-9
289
white prepupae new
287
white prepupae 12hr
259
white prepupae 24hr
318
pupae 2d postWPP
620
pupae 3d postWPP
2061
pupae 4d postWPP
3724
adult male 01day
2975
adult male 05day
1588
adult male 30day
837
adult female 01day
3223
adult female 05day
970
adult female 30day
818
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(741)
embryo 02-04hr
(376)
embryo 04-06hr
(206)
embryo 06-08hr
(273)
embryo 08-10hr
(336)
embryo 10-12hr
(535)
embryo 12-14hr
(488)
embryo 14-16hr
(1095)
embryo 16-18hr
(1147)
embryo 18-20hr
(1420)
embryo 20-22hr
(1570)
embryo 22-24hr
(1338)
larva L1
(2350)
larva L2
(2175)
larva L3 12hr old
(2185)
larva L3 puffstage 1-2
(761)
larva L3 puffstage 3-6
(422)
larva L3 puffstage 7-9
(289)
white prepupae new
(287)
white prepupae 12hr
(259)
white prepupae 24hr
(318)
pupae 2d postWPP
(620)
pupae 3d postWPP
(2061)
pupae 4d postWPP
(3724)
adult male 01day
(2975)
adult male 05day
(1588)
adult male 30day
(837)
adult female 01day
(3223)
adult female 05day
(970)
adult female 30day
(818)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(741)
embryo 02-04hr
(376)
embryo 04-06hr
(206)
embryo 06-08hr
(273)
embryo 08-10hr
(336)
embryo 10-12hr
(535)
embryo 12-14hr
(488)
embryo 14-16hr
(1095)
embryo 16-18hr
(1147)
embryo 18-20hr
(1420)
embryo 20-22hr
(1570)
embryo 22-24hr
(1338)
larva L1
(2350)
larva L2
(2175)
larva L3 12hr old
(2185)
larva L3 puffstage 1-2
(761)
larva L3 puffstage 3-6
(422)
larva L3 puffstage 7-9
(289)
white prepupae new
(287)
white prepupae 12hr
(259)
white prepupae 24hr
(318)
pupae 2d postWPP
(620)
pupae 3d postWPP
(2061)
pupae 4d postWPP
(3724)
adult male 01day
(2975)
adult male 05day
(1588)
adult male 30day
(837)
adult female 01day
(3223)
adult female 05day
(970)
adult female 30day
(818)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
741
embryo 02-04hr
376
embryo 04-06hr
206
embryo 06-08hr
273
embryo 08-10hr
336
embryo 10-12hr
535
embryo 12-14hr
488
embryo 14-16hr
1095
embryo 16-18hr
1147
embryo 18-20hr
1420
embryo 20-22hr
1570
embryo 22-24hr
1338
larva L1
2350
larva L2
2175
larva L3 12hr old
2185
larva L3 puffstage 1-2
761
larva L3 puffstage 3-6
422
larva L3 puffstage 7-9
289
white prepupae new
287
white prepupae 12hr
259
white prepupae 24hr
318
pupae 2d postWPP
620
pupae 3d postWPP
2061
pupae 4d postWPP
3724
adult male 01day
2975
adult male 05day
1588
adult male 30day
837
adult female 01day
3223
adult female 05day
970
adult female 30day
818
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
210
Schneider line 2 Sg4
190
embryonic 1182-4H
157
embryonic GM2
112
embryonic Kc167
74
embryonic S1
332
embryonic S3
212
leg disc CME L1
167
wing disc CME-W2
200
wing disc ML-DmD8
162
wing disc ML-DmD9
291
wing disc ML-DmD16-c3
171
wing disc ML-DmD21
172
wing disc ML-DmD32
135
haltere disc ML-DmD17-c3
471
eye-antennal disc ML-DmD11
417
antennal disc ML-DmD20-c5
194
mixed discs ML-DmD4-c1
135
CNS ML-DmBG1-c1
200
CNS ML-DmBG2-c2
90
tumorous blood cells mbn2
114
ovary fGS/OSS
107
ovary OSC
97
ovary OSS
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(210)
Schneider line 2 Sg4
(190)
embryonic 1182-4H
(157)
embryonic GM2
(112)
embryonic Kc167
(74)
embryonic S1
(332)
embryonic S3
(212)
leg disc CME L1
(167)
wing disc CME-W2
(200)
wing disc ML-DmD8
(162)
wing disc ML-DmD9
(291)
wing disc ML-DmD16-c3
(171)
wing disc ML-DmD21
(172)
wing disc ML-DmD32
(135)
haltere disc ML-DmD17-c3
(471)
eye-antennal disc ML-DmD11
(417)
antennal disc ML-DmD20-c5
(194)
mixed discs ML-DmD4-c1
(135)
CNS ML-DmBG1-c1
(200)
CNS ML-DmBG2-c2
(90)
tumorous blood cells mbn2
(114)
ovary fGS/OSS
(107)
ovary OSC
(97)
ovary OSS
(41)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(210)
Schneider line 2 Sg4
(190)
embryonic 1182-4H
(157)
embryonic GM2
(112)
embryonic Kc167
74
embryonic S1
(332)
embryonic S3
(212)
leg disc CME L1
(167)
wing disc CME-W2
(200)
wing disc ML-DmD8
(162)
wing disc ML-DmD9
(291)
wing disc ML-DmD16-c3
(171)
wing disc ML-DmD21
(172)
wing disc ML-DmD32
(135)
haltere disc ML-DmD17-c3
(471)
eye-antennal disc ML-DmD11
(417)
antennal disc ML-DmD20-c5
(194)
mixed discs ML-DmD4-c1
(135)
CNS ML-DmBG1-c1
(200)
CNS ML-DmBG2-c2
90
tumorous blood cells mbn2
(114)
ovary fGS/OSS
107
ovary OSC
97
ovary OSS
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
210
Schneider line 2 Sg4
190
embryonic 1182-4H
157
embryonic GM2
112
embryonic Kc167
74
embryonic S1
332
embryonic S3
212
leg disc CME L1
167
wing disc CME-W2
200
wing disc ML-DmD8
162
wing disc ML-DmD9
291
wing disc ML-DmD16-c3
171
wing disc ML-DmD21
172
wing disc ML-DmD32
135
haltere disc ML-DmD17-c3
471
eye-antennal disc ML-DmD11
417
antennal disc ML-DmD20-c5
194
mixed discs ML-DmD4-c1
135
CNS ML-DmBG1-c1
200
CNS ML-DmBG2-c2
90
tumorous blood cells mbn2
114
ovary fGS/OSS
107
ovary OSC
97
ovary OSS
41
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
210
Schneider line 2 Sg4
190
embryonic 1182-4H
157
embryonic GM2
112
embryonic Kc167
74
embryonic S1
332
embryonic S3
212
leg disc CME L1
167
wing disc CME-W2
200
wing disc ML-DmD8
162
wing disc ML-DmD9
291
wing disc ML-DmD16-c3
171
wing disc ML-DmD21
172
wing disc ML-DmD32
135
haltere disc ML-DmD17-c3
471
eye-antennal disc ML-DmD11
417
antennal disc ML-DmD20-c5
194
mixed discs ML-DmD4-c1
135
CNS ML-DmBG1-c1
200
CNS ML-DmBG2-c2
90
tumorous blood cells mbn2
114
ovary fGS/OSS
107
ovary OSC
97
ovary OSS
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(210)
Schneider line 2 Sg4
(190)
embryonic 1182-4H
(157)
embryonic GM2
(112)
embryonic Kc167
(74)
embryonic S1
(332)
embryonic S3
(212)
leg disc CME L1
(167)
wing disc CME-W2
(200)
wing disc ML-DmD8
(162)
wing disc ML-DmD9
(291)
wing disc ML-DmD16-c3
(171)
wing disc ML-DmD21
(172)
wing disc ML-DmD32
(135)
haltere disc ML-DmD17-c3
(471)
eye-antennal disc ML-DmD11
(417)
antennal disc ML-DmD20-c5
(194)
mixed discs ML-DmD4-c1
(135)
CNS ML-DmBG1-c1
(200)
CNS ML-DmBG2-c2
(90)
tumorous blood cells mbn2
(114)
ovary fGS/OSS
(107)
ovary OSC
(97)
ovary OSS
(41)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(210)
Schneider line 2 Sg4
(190)
embryonic 1182-4H
(157)
embryonic GM2
112
embryonic Kc167
74
embryonic S1
(332)
embryonic S3
(212)
leg disc CME L1
(167)
wing disc CME-W2
(200)
wing disc ML-DmD8
(162)
wing disc ML-DmD9
(291)
wing disc ML-DmD16-c3
(171)
wing disc ML-DmD21
(172)
wing disc ML-DmD32
135
haltere disc ML-DmD17-c3
(471)
eye-antennal disc ML-DmD11
(417)
antennal disc ML-DmD20-c5
(194)
mixed discs ML-DmD4-c1
135
CNS ML-DmBG1-c1
(200)
CNS ML-DmBG2-c2
90
tumorous blood cells mbn2
114
ovary fGS/OSS
107
ovary OSC
97
ovary OSS
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
210
Schneider line 2 Sg4
190
embryonic 1182-4H
157
embryonic GM2
112
embryonic Kc167
74
embryonic S1
332
embryonic S3
212
leg disc CME L1
167
wing disc CME-W2
200
wing disc ML-DmD8
162
wing disc ML-DmD9
291
wing disc ML-DmD16-c3
171
wing disc ML-DmD21
172
wing disc ML-DmD32
135
haltere disc ML-DmD17-c3
471
eye-antennal disc ML-DmD11
417
antennal disc ML-DmD20-c5
194
mixed discs ML-DmD4-c1
135
CNS ML-DmBG1-c1
200
CNS ML-DmBG2-c2
90
tumorous blood cells mbn2
114
ovary fGS/OSS
107
ovary OSC
97
ovary OSS
41
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
183
cold shock, 4-day adult
116
heat shock, 4-day adult
400
Cadmium 50 mM 6 hrs, larvae L3
420
Cadmium 50 mM 12 hrs, larvae L3
164
Cadmium 50 mM 48 hrs, 4-day adult
386
Cadmium 100 mM 48 hrs, 4-day adult
194
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
88
Zinc 5 mM 12 hrs, larvae L3
174
Zinc 4.5 mM 48 hrs, 4-day adult
111
Ethanol 2.5% 3 hrs, larvae L3
481
Ethanol 5% 3 hrs, larvae L3
414
Ethanol 10% 3 hrs, larvae L3
473
Caffeine 1.5 mg/ml 4 hrs, larvae L3
405
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
190
Caffeine 25 mg/ml 48 hrs, 4-day adult
130
Paraquat 5 mM 48 hrs, 4-day adult
324
Paraquat 10 mM 48 hrs, 4-day adult
372
Rotenone 2 μg 12 hrs, larvae L3
422
Rotenone 8 μg 12 hrs, larvae L3
742
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(183)
cold shock, 4-day adult
(116)
heat shock, 4-day adult
(400)
Cadmium 50 mM 6 hrs, larvae L3
(420)
Cadmium 50 mM 12 hrs, larvae L3
(164)
Cadmium 50 mM 48 hrs, 4-day adult
(386)
Cadmium 100 mM 48 hrs, 4-day adult
(194)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
(88)
Zinc 5 mM 12 hrs, larvae L3
(174)
Zinc 4.5 mM 48 hrs, 4-day adult
(111)
Ethanol 2.5% 3 hrs, larvae L3
(481)
Ethanol 5% 3 hrs, larvae L3
(414)
Ethanol 10% 3 hrs, larvae L3
(473)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(405)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(190)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(130)
Paraquat 5 mM 48 hrs, 4-day adult
(324)
Paraquat 10 mM 48 hrs, 4-day adult
(372)
Rotenone 2 μg 12 hrs, larvae L3
(422)
Rotenone 8 μg 12 hrs, larvae L3
(742)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
(183)
cold shock, 4-day adult
(116)
heat shock, 4-day adult
(400)
Cadmium 50 mM 6 hrs, larvae L3
(420)
Cadmium 50 mM 12 hrs, larvae L3
(164)
Cadmium 50 mM 48 hrs, 4-day adult
(386)
Cadmium 100 mM 48 hrs, 4-day adult
(194)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
88
Zinc 5 mM 12 hrs, larvae L3
(174)
Zinc 4.5 mM 48 hrs, 4-day adult
(111)
Ethanol 2.5% 3 hrs, larvae L3
(481)
Ethanol 5% 3 hrs, larvae L3
(414)
Ethanol 10% 3 hrs, larvae L3
(473)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(405)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(190)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(130)
Paraquat 5 mM 48 hrs, 4-day adult
(324)
Paraquat 10 mM 48 hrs, 4-day adult
(372)
Rotenone 2 μg 12 hrs, larvae L3
(422)
Rotenone 8 μg 12 hrs, larvae L3
(742)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
183
cold shock, 4-day adult
116
heat shock, 4-day adult
400
Cadmium 50 mM 6 hrs, larvae L3
420
Cadmium 50 mM 12 hrs, larvae L3
164
Cadmium 50 mM 48 hrs, 4-day adult
386
Cadmium 100 mM 48 hrs, 4-day adult
194
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
88
Zinc 5 mM 12 hrs, larvae L3
174
Zinc 4.5 mM 48 hrs, 4-day adult
111
Ethanol 2.5% 3 hrs, larvae L3
481
Ethanol 5% 3 hrs, larvae L3
414
Ethanol 10% 3 hrs, larvae L3
473
Caffeine 1.5 mg/ml 4 hrs, larvae L3
405
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
190
Caffeine 25 mg/ml 48 hrs, 4-day adult
130
Paraquat 5 mM 48 hrs, 4-day adult
324
Paraquat 10 mM 48 hrs, 4-day adult
372
Rotenone 2 μg 12 hrs, larvae L3
422
Rotenone 8 μg 12 hrs, larvae L3
742
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
183
cold shock, 4-day adult
116
heat shock, 4-day adult
400
Cadmium 50 mM 6 hrs, larvae L3
420
Cadmium 50 mM 12 hrs, larvae L3
164
Cadmium 50 mM 48 hrs, 4-day adult
386
Cadmium 100 mM 48 hrs, 4-day adult
194
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
88
Zinc 5 mM 12 hrs, larvae L3
174
Zinc 4.5 mM 48 hrs, 4-day adult
111
Ethanol 2.5% 3 hrs, larvae L3
481
Ethanol 5% 3 hrs, larvae L3
414
Ethanol 10% 3 hrs, larvae L3
473
Caffeine 1.5 mg/ml 4 hrs, larvae L3
405
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
190
Caffeine 25 mg/ml 48 hrs, 4-day adult
130
Paraquat 5 mM 48 hrs, 4-day adult
324
Paraquat 10 mM 48 hrs, 4-day adult
372
Rotenone 2 μg 12 hrs, larvae L3
422
Rotenone 8 μg 12 hrs, larvae L3
742
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(183)
cold shock, 4-day adult
(116)
heat shock, 4-day adult
(400)
Cadmium 50 mM 6 hrs, larvae L3
(420)
Cadmium 50 mM 12 hrs, larvae L3
(164)
Cadmium 50 mM 48 hrs, 4-day adult
(386)
Cadmium 100 mM 48 hrs, 4-day adult
(194)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
(88)
Zinc 5 mM 12 hrs, larvae L3
(174)
Zinc 4.5 mM 48 hrs, 4-day adult
(111)
Ethanol 2.5% 3 hrs, larvae L3
(481)
Ethanol 5% 3 hrs, larvae L3
(414)
Ethanol 10% 3 hrs, larvae L3
(473)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(405)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(190)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(130)
Paraquat 5 mM 48 hrs, 4-day adult
(324)
Paraquat 10 mM 48 hrs, 4-day adult
(372)
Rotenone 2 μg 12 hrs, larvae L3
(422)
Rotenone 8 μg 12 hrs, larvae L3
(742)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
(183)
cold shock, 4-day adult
116
heat shock, 4-day adult
(400)
Cadmium 50 mM 6 hrs, larvae L3
(420)
Cadmium 50 mM 12 hrs, larvae L3
(164)
Cadmium 50 mM 48 hrs, 4-day adult
(386)
Cadmium 100 mM 48 hrs, 4-day adult
(194)
Copper 0.5 mM 12 hrs, larvae L3
(245)
Copper 15 mM 48 hrs, 4-day adult
88
Zinc 5 mM 12 hrs, larvae L3
(174)
Zinc 4.5 mM 48 hrs, 4-day adult
111
Ethanol 2.5% 3 hrs, larvae L3
(481)
Ethanol 5% 3 hrs, larvae L3
(414)
Ethanol 10% 3 hrs, larvae L3
(473)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(405)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(190)
Caffeine 25 mg/ml 48 hrs, 4-day adult
130
Paraquat 5 mM 48 hrs, 4-day adult
(324)
Paraquat 10 mM 48 hrs, 4-day adult
(372)
Rotenone 2 μg 12 hrs, larvae L3
(422)
Rotenone 8 μg 12 hrs, larvae L3
(742)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
183
cold shock, 4-day adult
116
heat shock, 4-day adult
400
Cadmium 50 mM 6 hrs, larvae L3
420
Cadmium 50 mM 12 hrs, larvae L3
164
Cadmium 50 mM 48 hrs, 4-day adult
386
Cadmium 100 mM 48 hrs, 4-day adult
194
Copper 0.5 mM 12 hrs, larvae L3
245
Copper 15 mM 48 hrs, 4-day adult
88
Zinc 5 mM 12 hrs, larvae L3
174
Zinc 4.5 mM 48 hrs, 4-day adult
111
Ethanol 2.5% 3 hrs, larvae L3
481
Ethanol 5% 3 hrs, larvae L3
414
Ethanol 10% 3 hrs, larvae L3
473
Caffeine 1.5 mg/ml 4 hrs, larvae L3
405
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
190
Caffeine 25 mg/ml 48 hrs, 4-day adult
130
Paraquat 5 mM 48 hrs, 4-day adult
324
Paraquat 10 mM 48 hrs, 4-day adult
372
Rotenone 2 μg 12 hrs, larvae L3
422
Rotenone 8 μg 12 hrs, larvae L3
742
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 29 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 2 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Not disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions insertion of mobile activating element
insertion of enhancer trap
insertion of enhancer trap binary system
Gene Ontology: Function, Process
& Cellular Component ( 14 unique terms ) Terms Based on
Experimental Evidence ( 6 terms ) Molecular Function ( 0 terms) Biological Process inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or
Assertions ( 8 terms ) Molecular Function non-traceable author statement
Biological Process non-traceable author statement
Cellular Component Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
experimental knowledge based
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
experimental knowledge based
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (41)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6H72X5 )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6TXC15 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6SQVRT )
Apis mellifera
Western honey bee
Amel\Atp5a1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009612
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\atpA
Atta cephalotes
Leafcutter ant
Acep\ACEP25038
Atta cephalotes
Leafcutter ant
Acep\ACEP13242
Camponotus floridanus
Florida carpenter ant
Cflo\atpA
Harpegnathos saltator
Jerdons jumping ant
Hsal\atpA
Linepithema humile
Argentine ant
Lhum\LH19336
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB20892
Solenopsis invicta
Red fire ant
Sinv\SINV10691
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6QBZMJ )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6103QS )
Caenorhabditis elegans
Nematode
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 14 )Bloomington Kyoto VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 932 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Source for merge of: blw ATPsyn-α
Source for merge of: blw l(2)03972 l(2)k00212 l(2)01410 ATPsyn-α
Additional comments Other Comments S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Identification: One of a collection of genes identified with defective larval growth that extend larval life.
Postmeiotic differentiation defect.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- A database of annotated Dmel nuclear genes encoding mitochondrial proteins
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 32 )Reported As Symbol Synonym blw
(
Wang et al., 2004 ,
Beller et al., 2006 ,
Cermelli et al., 2006 ,
Stroschein-Stevenson et al., 2006 ,
Liebl et al., 2006 ,
Christensen et al., 2008.9.3 ,
Dorus et al., 2006 ,
Xing et al., 2007 ,
FlyBase Curators, 2008 ,
Porcelli et al., 2007 ,
Tripoli et al., 2005 ,
Rees et al., 2011 ,
Kallappagoudar et al., 2010 ,
Rathke et al., 2007 ,
Ozdowski et al., 2009 ,
Chen et al., 2008 ,
Monzo et al., 2010 ,
Tiefenböck et al., 2010 ,
Wasbrough et al., 2010 ,
Wasbrough et al., 2010 ,
Abruzzi et al., 2011 ,
Alonso et al., 2005 ,
Malone et al., 2012 )
CG3612
(
Fulton et al., 2001 ,
Cermelli et al., 2006 ,
Terhzaz et al., 2006 ,
Porcelli et al., 2007 ,
Lindsay et al., 2008 ,
Perkins et al., 2009 ,
Baltzer et al., 2009 ,
Hughes et al., 2008 ,
Chen et al., 2008 ,
Monzo et al., 2010 ,
Tiefenböck et al., 2010 ,
Cammarato et al., 2011 )
Name Synonym ATP synthase subunit alpha
bellwether
(
Cermelli et al., 2006 ,
Xing et al., 2007 ,
Rathke et al., 2007 ,
Harbison et al., 2005 ,
Tiefenböck et al., 2010 ,
Wasbrough et al., 2010 ,
Sun et al., 2011 ,
Cammarato et al., 2011 )
mitochondrial ATP synthase alpha subunit
mitochondrial ATP synthase subunit alpha of complex V
Mitochondrial ATP synthase subunit B
α subunit of ATP synthase
α subunit of the mitochondrial F1 F0 ATPase
Secondary FlyBase
IDs FBgn0010487 FBgn0010561 FBgn0011298 FBgn0022274 References ( 86 )Generate a list of List References by type
Recent research papers ( 7 )
Duboff et al., 2012, Neuron 75(4): 618--632Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Fukuyama et al., 2012, J. Proteomics 75(15): 4610--4619On-bead tryptic proteolysis: An attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. [FBrf0218992] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Malone et al., 2012, Genome Biol. 13(4): r28Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Sun et al., 2011, PLoS ONE 6(4): e18215Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. [FBrf0213560]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011