UbcD1, ms(3)88D, E(Pc)88D, UBC4, Ubiquitin conjugating enzyme 1
E2 ubiquitin-conjugating enzyme - mediates anaphase-promoting complex degradation - controls germ-line stem cell maintenance by targeting Cyclin A - regulates programmed cell death and neuronal process remodeling
Gene model reviewed during 5.53
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Gene model reviewed during 5.54
2.1, 1.9, 1.7 (northern blot)
147 (aa); 17 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eff using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\eff in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: eff CG7425
Source for merge of eff anon-WO0118547.343 was sequence comparison ( date:051113 ).
DNA-protein interactions: genome-wide binding profile assayed for eff protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
Area matching Drosophila EST AI297203. This EST forms a 1122bp contig with AI455195 and AA438815.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
eff encodes a class I ubiquitin-conjugating enzyme required for proper telomere behaviour.
Mutants affect telomere behavior during mitosis and male meiosis. Some form of ubiquitin-mediated proteolysis must occur in wild type cells to resolve the adhesion of telomeres prior to chromosome separation.
Postmeiotic differentiation defect.
Isolated by PCR using primers specific for yeast UBC1, UBC4, UBC5 ubiquitin-conjugating enzyme subfamily.
Named 'UbcD1' for 'ubiquitin-conjugating enzyme from Drosophila 1 (the numbering reflects the order of identification).
Named 'UbcD1' for 'ubiquitin-conjugating enzyme from Drosophila melanogaster 1'. (The numbering reflects the order of gene identification and does NOT follow the numbering of yeast UBC genes).