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Gene Dmel\heph

General Information
Symbol	Dmel\heph	Species	D. melanogaster
Name	hephaestus	Annotation symbol	CG31000
Feature type	protein_coding_gene	FlyBase ID	FBgn0011224
Gene Model Status	Current	Stock availability	71 publicly available
Also Known As	PTB, CG2094, l(3)03429, dmPTB, ema
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D3-100E1	Sequence location	3R:27,672,709..27,819,000 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: mRNA 3'-UTR binding; translation repressor activity, nucleic acid binding. There is experimental evidence that it is involved in the biological process: spermatid development; imaginal disc-derived wing margin morphogenesis; response to DNA damage stimulus; sperm individualization; oocyte microtubule cytoskeleton polarization; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway; negative regulation of oskar mRNA translation; regulation of response to DNA damage stimulus. 122 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; elongation stage spermatid; macrochaeta; testis; mesothoracic tergum; wing; spermatid cyst; individualization stage spermatid; spermatozoon. It has 24 annotated transcripts and 24 annotated polypeptides. Protein features are: HnRNP-L/PTB/hephaestus splicing factor; Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1637478_s_at completely aligns to an exonic region of only a subset of 21 of the 22 FlyBase-annotated transcript isoforms of heph. Gene sequence location is 3R:27672709..27819000.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles heph[MI03453]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D3-100E1   Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100F-100F   (determined by in situ hybridisation)   (Weber et al., 2005) 100F-100F     (Standiford, 1999.12.3) 100F1-100F5   (determined by in situ hybridisation) 100E1--3 (determined by in situ hybridisation)   (Spradling et al., 1999) 100F1-100F5   74D3--5 100E1--3   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\heph for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated. Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all supported alternative splices within 5' UTR. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) heph-RA FBtr0085879  NM_170582   3333   608 heph-RB FBtr0085878  NM_170581   2405   608 heph-RC FBtr0085880  NM_079964   2979   581 heph-RD FBtr0085882  NM_176596   2915   608 heph-RE FBtr0085883  NM_176597   3821   608 heph-RF FBtr0085888  NM_176598   3427   608 heph-RG FBtr0085887  NM_176599   2986   615 heph-RH FBtr0085881  NM_176603   3493   789 heph-RI FBtr0085884  NM_176600   3026   608 heph-RJ FBtr0085885  NM_176601   3084   608 heph-RK FBtr0085886  NM_176602   2846   608 heph-RL FBtr0112864  NM_001104522   3839   622 heph-RM FBtr0112865  NM_001104523   3424   568 heph-RN FBtr0112866  NM_001104524   7366   608 heph-RO FBtr0300263  NM_001170316   3493   789 heph-RP FBtr0300264  NM_001170317   2592   608 heph-RQ FBtr0300265  NM_001170318   2391   493 heph-RR FBtr0300266  NM_001170319   3496   789 heph-RS FBtr0300267  NM_001170320   3715   581 heph-RT FBtr0300268  NM_001170321   3157   581 heph-RU FBtr0300269  NM_001170322   7770   581 heph-RV FBtr0300270  NM_001170323   3128   608 heph-RW FBtr0306692  NM_001260469   3651   799 heph-RY FBtr0306693  NM_001260470   3869   898
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein heph-PA   FBpp0085238   65.5   608   9.25     NP_733461   AAN14297 heph-PB   FBpp0085237   65.5   608   9.25     NP_733460   AAF57208 heph-PC   FBpp0085239   62.6   581   9.36     NP_524703   AAN14296 heph-PD   FBpp0085241   65.5   608   9.25     NP_788773   AAO41620 heph-PE   FBpp0085242   65.5   608   9.25     NP_788774   AAO41621 heph-PF   FBpp0085247   65.5   608   9.25     NP_788775   AAO41622 heph-PG   FBpp0085246   66.3   615   9.25     NP_788776   AAO41623 heph-PH   FBpp0085240   84.6   789   9.32     NP_788780   AAO41627 heph-PI   FBpp0085243   65.5   608   9.25     NP_788777   AAO41624 heph-PJ   FBpp0085244   65.5   608   9.25     NP_788778   AAO41625 heph-PK   FBpp0085245   65.5   608   9.25     NP_788779   AAO41626 heph-PL   FBpp0111777   67.3   622   9.21     NP_001097992   ABW08816 heph-PM   FBpp0111778   61.2   568   9.47     NP_001097993   ABW08817 heph-PN   FBpp0111779   65.5   608   9.25     NP_001097994   ABW08818 heph-PO   FBpp0289491   84.6   789   9.32     NP_001163787   ACZ95080 heph-PP   FBpp0289492   65.5   608   9.25     NP_001163788   ACZ95081 heph-PQ   FBpp0289493   53.4   493   9.27     NP_001163789   ACZ95082 heph-PR   FBpp0289494   84.6   789   9.32     NP_001163790   ACZ95083 heph-PS   FBpp0289495   62.6   581   9.36     NP_001163791   ACZ95084 heph-PT   FBpp0289496   62.6   581   9.36     NP_001163792   ACZ95085 heph-PU   FBpp0289497   62.6   581   9.36     NP_001163793   ACZ95086 heph-PV   FBpp0289498   65.5   608   9.25     NP_001163794   ACZ95087 heph-PW   FBpp0297631   86.0   799   9.28     NP_001247398   AFH06715 heph-PY   FBpp0297632   95.7   898   9.31     NP_001247399   AFH06716
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) HnRNP-L/PTB/hephaestus splicing factor (IPR006536) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140932   AA141121   AA141124   AA141127   AA141143   AA141196   AA141199   AA141201   AA141234   AA141323   AA141354   AA141371   AA141408   AA141422   AA141464   AA141478   AA141489   AA141497   AA141560   AA141562   AA141609   AA141611   AA141655   AA141707   AA141711   AA141735   AA141743   AA141801   AA141834   AA141881   AA142178   AA142302   AA201355   AA202345   AA202411   AA202699   AA202791   AA246357   AA264373   AA392237   AA438701   AA440163   AA539665   AA540904   AA698868   AA735919   AA948855   AE014297 AAF57208   AE014297 AAN14296   AE014297 AAN14297   AE014297 AAO41620   AE014297 AAO41621   AE014297 AAO41622   AE014297 AAO41623   AE014297 AAO41624   AE014297 AAO41625   AE014297 AAO41626   AE014297 AAO41627   AE014297 ABW08816   AE014297 ABW08817   AE014297 ABW08818   AE014297 ACZ95080   AE014297 ACZ95081   AE014297 ACZ95082   AE014297 ACZ95083   AE014297 ACZ95084   AE014297 ACZ95085   AE014297 ACZ95086   AE014297 ACZ95087   AF211191 AAF22979   AF373596   AF436844 AAL27010   AF455053 AAL57860   AE014297 AFH06715   AE014297 AFH06716   AI124308   AI296338   AI387029   AI387761   AI388789   AI512776   AI520203   AI531290   AQ026438   AW942041   AY052367 AAL14775   AY069318 AAL39463   AY118448 AAM48477   AY628765 AAT72299   BF485596   BF504718   BI142244   BI163823   BI164745   BI169271   BI212513   BI230813   BI240537   BI242229   BI352942   BI357878   BI362798   BI363479   BI363535   BI363838   BI370291   BI374153   BI482383   BI564851   BI565487   BI571886   BI574131   BI575214   BI576026   BI577030   BI579247   BI582454   BI583280   BI583851   BI583993   BI586861   BI588375   BI588406   BI588459   BI588663   BI588766   BI588884   BI589090   BI589239   BI589243   BI590672   BI590731   BI592794   BI593032   BI604445   BI605511   BI606547   BI607294   BI607877   BI607977   BI608784   BI608982   BI610522   BI610661   BI611018   BI611097   BI611159   BI611230   BI611710   BI612977   BI613020   BI613394   BI613754   BI615370   BI615509   BI616145   BI616581   BI616610   BI616906   BI617028   BI617090   BI617439   BI617684   BI618824   BI619653   BI620053   BI620538   BI620781   BI621147   BI621284   BI622500   BI622740   BI623088   BI623093   BI623319   BI623627   BI624745   BI625317   BI625766   BI625785   BI625802   BI626350   BI626426   BI626450   BI626871   BI627441   BI627518   BI627695   BI628367   BI628419   BI628426   BI628436   BI628544   BI629001   BI629129   BI629190   BI629211   BI629381   BI630149   BI630924   BI631188   BI631763   BI631785   BI631828   BI631848   BI631900   BI631995   BI634197   BI634339   BI634950   BI636622   BI640181   BI641728   BP541217   BP541218   BP546438   BP550799   BP550800   BP551794   BP551795   BT025074   BT030984   BT032832   CK135088   CK135090   CK135361   CL943562   CO153494   CO176919   CO176970   CO177555   CO178194   CO178921   CO179042   CO179169   CO179305   CO181728   CO185833   CO186354   CO187196   CO187636   CO187678   CO187710   CO187913   CO189129   CO190350   CO190773   CO190945   CO190982   CO195863   CO261955   CO262040   CO262568   CO263244   CO263356   CO263378   CO263592   CO263824   CO264447   CO264634   CO265341   CO265814   CO266208   CO266621   CO267062   CO267203   CO267454   CO267553   CO268027   CO268246   CO268650   CO269538   CO269597   CO269696   CO270670   CO271022   CO271850   CO271971   CO273201   CO273696   CO273774   CO274206   CO274807   CO274813   CO275125   CO275338   CO275570   CO275968   CO276510   CO276551   CO276794   CO277741   CO278383   CO278479   CO278699   CO279082   CO280443   CO280554   CO281966   CO282275   CO282395   CO282855   CO284008   CO284137   CO284265   CO284404   CO286117   CO286415   CO286623   CO287655   CO287859   CO288073   CO288960   CO289699   CO290180   CO290679   CO290755   CO290759   CO291316   CO291587   CO291731   CO291788   CO291860   CO292428   CO292565   CO292855   CO293512   CO293878   CO294202   CO294380   CO294540   CO295238   CO296547   CO296830   CO296853   CO297010   CO297561   CO298049   CO298846   CO300381   CO300478   CO301945   CO302049   CO302309   CO302349   CO302681   CO303318   CO303356   CO303980   CO304026   CO304294   CO304865   CO304946   CO307131   CO307591   CO308453   CO309390   CO309805   CO310246   CO310496   CO310899   CO311693   CO311933   CO312111   CO312182   CO313091   CO314026   CO314398   CO314405   CO314641   CO316085   CO316352   CO316667   CO317355   CO318556   CO319292   CO319523   CO319557   CO320327   CO320638   CO320976   CO320977   CO321684   CO322033   CO323549   CO323649   CO324299   CO324658   CO324776   CO326836   CO326862   CO326952   CO327048   CO327604   CO328187   CO328257   CO328314   CO328871   CO329111   CO330975   CO331769   CO331792   CO332493   CO332498   CO332733   CO333886   CO337673   CO338920   CO339123   CO339169   CO339598   CO339604   CO340021   CO340197   CO340225   CO340355   CO340387   CO340748   CO340851   CO340882   CO340913   CO340947   CO341122   CO341401   CO341778   CO341986   CO342090   CO342406   CO343368   CO343580   CO343708   CO343712   CO344264   CO344379   CO344766   CO344802   CO344964   CO344971   CZ466145   CZ466200   CZ466226   CZ466234   CZ466280   CZ466302   CZ466308   CZ466309   CZ466574   CZ466679   CZ466758   CZ466759   CZ466774   CZ466799   CZ466876   CZ467131   CZ467223   CZ467244   CZ467246   CZ467291   CZ467292   CZ467315   CZ467481   CZ469436   CZ469917   CZ470085   CZ470121   CZ470534   CZ471014   CZ471262   CZ472056   CZ472224   CZ474158   CZ474624   CZ474625   CZ474626   CZ474718   CZ474719   CZ475005   CZ475006   CZ475149   CZ477005   CZ477108   CZ478315   CZ478792   CZ479451   CZ481144   CZ481246   CZ481330   CZ483022   CZ483620   CZ483621   CZ483720   CZ484010   CZ484513   CZ484514   CZ485140   CZ486163   CZ487655   CZ489693   CZ489843   CZ489844   EC058551   EC058968   EC059773   EC059862   EC063775   EC064267   EC068972   EC070550   EC071661   EC071975   EC073993   EC074206   EC075296   EC076707   EC076860   EC078470   EC078674   EC079407   EC080085   EC080965   EC081199   EC081474   EC082363   EC084115   EC085332   EC085844   EC086570   EC088006   EC088185   EC088186   EC088292   EC088652   EC089777   EC194661   EC194810   EC195018   EC195625   EC196853   EC196854   EC197102   EC197331   EC197968   EC198453   EC199673   EC201020   EC201805   EC202144   EC204767   EC206137   EC207217   EC207513   EC208429   EC208440   EC208997   EC210517   EC211426   EC211818   EC212407   EC213971   EC215695   EC217955   EC218959   EC220978   EC220979   EC221240   EC223246   EC227384   EC228107   EC228528   EC230709   EC230883   EC232888   EC233825   EC234523   EC235229   EC235453   EC236559   EC237997   EC238436   EC239451   EC240077   EC242463   EC242896   EC243124   EC243543   EC243866   EC244558   EC244642   EC245376   EC245544   EC245820   EC247102   EC248199   EC249414   EC250288   EC250592   EC250636   EC250910   EC251047   EC251689   EC254226   EC255323   EC256351   EC257191   EC259092   EL884130   EL884131   EL884260   EL884261   EV578250   EV581094   EV591676   G00761
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KES3 Q7KRS7 Q8IMF8 Q8WR53 Q95UI6 A8JRI1 E1JJ45 Q8T0H5 Q3T7F7 Q8MT11
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   foregut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Besse et al., 2009) ribonucleoprotein complex inferred from direct assay (Besse et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass    533.275 Adult Head    71 Adult Eye    42.7 Adult Brain    796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass  533.275 Adult Head    71 Adult Eye    42.7 Adult Brain  (796.8) Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass    533.275 Adult Head    71 Adult Eye    42.7 Adult Brain    796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass    533.275 Adult Head    71 Adult Eye    42.7 Adult Brain    796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass    533.275 Adult Head    71 Adult Eye    42.7 Adult Brain    796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass  533.275 Adult Head    71 Adult Eye    42.7 Adult Brain  796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass    533.275 Adult Head    71 Adult Eye    42.7 Adult Brain    796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468 Larval Midgut    44.4 Larval Hindgut    241 Larval Malpighian Tubules    26.3 Larval Fat Body    27.1 Larval Salivary Gland    101.7 Larval Trachea    345.95 Larval Carcass    533.275 Adult Head    71 Adult Eye    42.7 Adult Brain    796.8 Adult Thoracic-Abdominal Ganglion    304.3 Adult Crop    92.8 Adult Midgut    15.6 Adult Hindgut    55.3 Adult Malpighian Tubules    12.2 Adult Fat Body    52.7 Adult Salivary Gland    18 Adult Heart    24.95 Adult VirginFemale Spermatheca    59 Adult InseminatedFemale Spermatheca    79 Adult Ovary    405 Adult Testis    40.3 Adult Male Accessory Gland    118.6 Adult Carcass    35.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    71   NA  Eye    42.7   NA  Brain    796.8   468  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    304.3   NA  Crop    92.8   44.4  Midgut    no informative data   241  Hindgut    55.3   26.3  Malpighian Tubules    no informative data   27.1  Fat Body    52.7   101.7  Salivary Gland    no informative data   NA  Heart    no informative data   345.95  Trachea    NA   NA  VirginFemale Spermatheca    59   NA  InseminatedFemale Spermatheca    79   NA  Ovary    405   NA  Testis    40.3   NA  Male Accessory Gland    118.6   533.275  Carcass    35.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    40 central nervous system, pupae P8    85 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    31 head, mated 4-day male    30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering    66 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female    45 ovary, mated 4-day female    34 testis, mated 4-day male    45 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3  (40) central nervous system, pupae P8  (85) head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male  (31) head, mated 4-day male  (30) head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering  (66) carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female  (45) ovary, mated 4-day female  (34) testis, mated 4-day male  (45) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3    40 central nervous system, pupae P8    85 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    31 head, mated 4-day male    30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering    66 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female    45 ovary, mated 4-day female    34 testis, mated 4-day male    45 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    40 central nervous system, pupae P8    85 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    31 head, mated 4-day male    30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering    66 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female    45 ovary, mated 4-day female    34 testis, mated 4-day male    45 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    40 central nervous system, pupae P8    85 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    31 head, mated 4-day male    30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering    66 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female    45 ovary, mated 4-day female    34 testis, mated 4-day male    45 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3  (40) central nervous system, pupae P8  (85) head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male  31 head, mated 4-day male  30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering  (66) carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female  (45) ovary, mated 4-day female  (34) testis, mated 4-day male  (45) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3    40 central nervous system, pupae P8    85 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    31 head, mated 4-day male    30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering    66 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female    45 ovary, mated 4-day female    34 testis, mated 4-day male    45 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    40 central nervous system, pupae P8    85 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    20 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    31 head, mated 4-day male    30 head, mated 20-day male    24 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    18 fat body, pupae P8    24 carcass, larvae L3 wandering    66 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    5 ovary, virgin 4-day female    45 ovary, mated 4-day female    34 testis, mated 4-day male    45 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    30 white prepupae 24hr    49 pupae 2d postWPP    26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  (32) embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (30) white prepupae new  (28) white prepupae 12hr  (30) white prepupae 24hr  (49) pupae 2d postWPP  26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    30 white prepupae 24hr    49 pupae 2d postWPP    26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    30 white prepupae 24hr    49 pupae 2d postWPP    26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    30 white prepupae 24hr    49 pupae 2d postWPP    26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  30 white prepupae new  28 white prepupae 12hr  30 white prepupae 24hr  (49) pupae 2d postWPP  26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    30 white prepupae 24hr    49 pupae 2d postWPP    26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    32 embryo 04-06hr    14 embryo 06-08hr    13 embryo 08-10hr    17 embryo 10-12hr    13 embryo 12-14hr    16 embryo 14-16hr    10 embryo 16-18hr    14 embryo 18-20hr    10 embryo 20-22hr    16 embryo 22-24hr    20 larva L1    9 larva L2    6 larva L3 12hr old    4 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    30 white prepupae 24hr    49 pupae 2d postWPP    26 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    13 adult male 05day    17 adult male 30day    13 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3    37 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3  (37) leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3    37 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3    37 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3    37 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3  (37) leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3    37 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    6 embryonic 1182-4H    4 embryonic GM2    4 embryonic Kc167    13 embryonic S1    5 embryonic S3    37 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    5 ovary fGS/OSS    18 ovary OSC    12 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3  26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (32) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (37) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3  26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (37) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD04329 LD03185 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011224 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31000-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for heph Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal hephCC00664 lethal | heat sensitive heph2 lethal | recessive heph03429 hephe1 hephe2 hephj11B9 viable hephEY13208 hephPL00536 hephPTT hephW18 viable, with Scer\GAL4pnr-MD237 hephGD10126 Sterility Allele female fertile heph2-dl fertile hephEY13208 hephPL00536 male sterile heph1 heph2 heph2-dl male sterile (with heph2) heph03429 hephe1 hephe2 hephj11B9 male sterile (with heph03429) heph2 male sterile (with hephe1) heph2 male sterile (with hephe2) heph2 male sterile (with hephj11B9) heph2 male sterile | recessive heph1 heph2 Other Phenotypes Allele learning defective | adult stage heph9.189 heph18.104 mitotic cell cycle defective hephEP3574 visible, with Scer\GAL4pnr-MD237 hephGD10126 visible | somatic clone heph03429 hephe1 hephe2 hephj11B9 Phenotype manifest in Allele elongation stage spermatid heph2 heph2-dl embryonic head | germline clone heph03429 germline cell | male, with Scer\GAL4nos.UTR.T:Hsim\VP16 hephEP3204 hephScer\UAS.cSa individualization stage spermatid heph2 heph2-dl macrochaeta hephBG02287 mesothoracic tergum, with Scer\GAL4pnr-MD237 hephGD10126 spermatid cyst heph2 heph2-dl spermatozoon heph2 testis heph1 heph2 heph2-dl trichogen cell, with Scer\GAL4pnr-MD237 hephGD10126 wing hephW18 wing | somatic clone heph03429 wing margin | ectopic | somatic clone heph03429 hephe1 hephj11B9 wing margin | somatic clone heph03429 wing vein | cell autonomous | somatic clone heph03429 hephe1 hephe2 hephj11B9
Classical Alleles ( 115 )
For All Classical Alleles Show
Allele of heph Class Mutagen Stocks Known lesion heph03429 P-element activity 1 Yes heph2 heat sensitive loss of function allele P-element activity 1 Yes heph5-HA-1093 1 -- heph5-HA-1486 1 -- hephc00105 piggyBac transposase 1 -- hephc00135 piggyBac transposase 1 -- hephc00147 piggyBac transposase 1 -- hephc00241 piggyBac transposase 1 -- hephc00583 piggyBac transposase 1 -- hephc00594 1 -- hephc00841 piggyBac transposase 1 -- hephc00864 piggyBac transposase 1 -- hephc01005 piggyBac transposase 1 -- hephc01059 1 -- hephc01312a 1 -- hephc01397 piggyBac transposase 1 -- hephc01512 piggyBac transposase 1 -- hephc01549 piggyBac transposase 1 -- hephc01551 piggyBac transposase 1 -- hephc01602 piggyBac transposase 1 -- hephc01754 1 -- hephc01885 1 -- hephc02484 1 -- hephc03358 1 -- hephc04692 piggyBac transposase 1 -- hephc05162 1 -- hephc05545 piggyBac transposase 1 -- hephc06244 piggyBac transposase 1 -- hephCB-0275-3 1 -- hephCB-0659-3 1 -- hephCB-5616-3 1 -- hephCB-6299-3 1 -- hephd04828 P-element activity 1 -- hephd05595 P-element activity 1 -- hephd06250 P-element activity 1 -- hephd08300 1 -- hephd09267 1 -- hephd09905 P-element activity 1 -- hephDG10602 1 -- hephe00428 piggyBac transposase 1 -- hephe03374 piggyBac transposase 1 -- hephe03472 piggyBac transposase 1 -- hephe03574 piggyBac transposase 1 -- hephEY13208 P-element activity 1 -- hephf00564 piggyBac transposase 1 -- hephf01133 piggyBac transposase 1 -- hephf01545 piggyBac transposase 1 -- hephf02019 piggyBac transposase 1 -- hephf02612 piggyBac transposase 1 -- hephf03585 piggyBac transposase 1 -- hephf06953 piggyBac transposase 1 -- hephMB01096 1 -- hephMI02569 1 -- hephMI02609 1 -- hephMI03238 1 -- hephMI03453 1 -- hephMI04030 1 -- hephMI04235 1 -- hephMI04855 1 -- hephNP3019 1 -- hephNP6506 1 -- hephNP6544 1 -- hephNP6560 1 -- hephNP7447 1 -- hephNP7516 1 -- hephPL00536 P-element activity 1 -- hephUM-8349-3 1 -- heph18.104 0 Yes heph1 P-element activity 0 -- heph2-dl P-element activity 0 Yes heph2-ex P-element activity 0 Yes heph9.189 0 Yes hephBG02287 P-element activity 0 Yes hephc00005 piggyBac transposase 0 -- hephc00216 piggyBac transposase 0 -- hephc00235 piggyBac transposase 0 -- hephc00725 piggyBac transposase 0 -- hephc01085 piggyBac transposase 0 -- hephc01379 0 -- hephc01635 piggyBac transposase 0 -- hephc01827 piggyBac transposase 0 -- hephc01843 0 -- hephc05368 piggyBac transposase 0 -- hephc05593 piggyBac transposase 0 -- hephc06824 piggyBac transposase 0 -- hephc07125 piggyBac transposase 0 -- hephCC00664 P-element activity 0 Yes hephCPTI000030 piggyBac transposase 0 Yes hephCPTI002406 piggyBac transposase 0 Yes hephCPTI002584 piggyBac transposase 0 Yes hephd01137 P-element activity 0 -- hephd01420 P-element activity 0 -- hephd05596 P-element activity 0 -- hephd05770 P-element activity 0 -- hephd06469 P-element activity 0 -- hephd07187 0 -- hephd10112 P-element activity 0 -- hephe00963 piggyBac transposase 0 -- hephe01647 piggyBac transposase 0 -- hephe1 0 Yes hephe2 ethyl methanesulfonate 0 Yes hephEP3016 0 -- hephEP3204 P-element activity 0 Yes hephEP3574 P-element activity 0 Yes hephEP3612 P-element activity 0 -- hephex3.4 FLPase 0 Yes hephf01245 piggyBac transposase 0 -- hephf05053 piggyBac transposase 0 -- hephf07076 piggyBac transposase 0 -- hephf07875 0 -- hephGS-A1768 Delta2-3 0 -- hephj11B9 P-element activity 0 Yes hephPTT 0 Yes hephs3441 P-element activity 0 -- hephW18 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of heph Class Mutagen Stocks Known lesion hephGD10126 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes hephGLV21034 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hephJF02366 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hephKK108057 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes hephNIG.2094R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes hephScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes hephαTub67C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hephΔNLS.αTub67C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3R)RhoGAP100Fex3.4 (Owald et al., 2010)
Disrupted in	Df(3R)04661 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)BSC687 (Cook et al., 2008.12.28) Df(3R)G45-53 (Dansereau et al., 1999, Dansereau et al., 2002)
Not disrupted in	Df(3R)awd-KRB (Cook, 2006.1.31) T(Y;3)R133 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10126} NA P{KK108057} NA P{NIG.2094R} NA P{TRiP.GLV21034} NA P{TRiP.JF02366} NA P{UAS-heph.S} NA characterization construct P{αTub67C-heph.GFP} NA P{αTub67C-heph.ΔNLS.GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}hephj11B9 No P{lacW}hephs3441 No P{lacW}hephW18 No P{PZ}G45 No P{PZ}heph1 No P{PZ}heph2 No P{PZ}heph03429 No insertion of mobile activating element P{EP}CG2003EP3204 NA P{EP}CG2003EP3574 NA P{EP}hephEP3016 NA P{EP}hephEP3612 NA P{EPgy2}hephEY13208 NA P{GSV1}hephGS-A1768 NA P{XP}hephd01137 NA P{XP}hephd01420 NA P{XP}hephd04828 NA P{XP}hephd05595 NA P{XP}hephd05596 NA P{XP}hephd05770 NA P{XP}hephd06250 NA P{XP}hephd06469 NA P{XP}hephd07187 NA P{XP}hephd08300 NA P{XP}hephd09267 NA P{XP}hephd09905 NA P{XP}hephd10112 NA miscellaneous insertions Mi{MIC}hephMI02569 NA Mi{MIC}hephMI02609 NA Mi{MIC}hephMI03238 NA Mi{MIC}hephMI03453 NA Mi{MIC}hephMI04030 NA Mi{MIC}hephMI04235 NA Mi{MIC}hephMI04855 NA P{GT1}hephBG02287 NA P{PTT-GC}hephCC00664 NA P{PTT-un1}hephPTT NA P{RS3}hephCB-0275-3 NA P{RS3}hephCB-0659-3 NA P{RS3}hephCB-5616-3 NA P{RS3}hephCB-6299-3 NA P{RS3}hephUM-8349-3 NA P{RS5}heph5-HA-1093 NA P{RS5}heph5-HA-1486 NA P{wHy}hephDG10602 NA PBac{544.SVS-1}hephCPTI002406 NA PBac{602.P.SVS-1}hephCPTI000030 NA PBac{754.P.FSVS-0}hephCPTI002584 NA PBac{PB}hephc00005 NA PBac{PB}hephc00105 NA PBac{PB}hephc00135 NA PBac{PB}hephc00147a NA PBac{PB}hephc00147b NA PBac{PB}hephc00216 NA PBac{PB}hephc00235 NA PBac{PB}hephc00241a NA PBac{PB}hephc00241b NA PBac{PB}hephc00583 NA PBac{PB}hephc00594 NA PBac{PB}hephc00725 NA PBac{PB}hephc00841 NA PBac{PB}hephc00864 NA PBac{PB}hephc01005 NA PBac{PB}hephc01059 NA PBac{PB}hephc01085 NA PBac{PB}hephc01312a NA PBac{PB}hephc01379 NA PBac{PB}hephc01397 NA PBac{PB}hephc01512 NA PBac{PB}hephc01549 NA PBac{PB}hephc01551 NA PBac{PB}hephc01602 NA PBac{PB}hephc01635 NA PBac{PB}hephc01754 NA PBac{PB}hephc01827 NA PBac{PB}hephc01843 NA PBac{PB}hephc01885 NA PBac{PB}hephc02484 NA PBac{PB}hephc03358 NA PBac{PB}hephc04692 NA PBac{PB}hephc05162 NA PBac{PB}hephc05368 NA PBac{PB}hephc05545 NA PBac{PB}hephc05593 NA PBac{PB}hephc06244 NA PBac{PB}hephc06824 NA PBac{PB}hephc07125 NA PBac{RB}hephe00428 NA PBac{RB}hephe00963 NA PBac{RB}hephe01647 NA PBac{RB}hephe03374 NA PBac{RB}hephe03472 NA PBac{RB}hephe03574 NA PBac{WH}hephf00564 NA PBac{WH}hephf01133 NA PBac{WH}hephf01245 NA PBac{WH}hephf01545 NA PBac{WH}hephf02019 NA PBac{WH}hephf02612 NA PBac{WH}hephf03585 NA PBac{WH}hephf05053 NA PBac{WH}hephf06953 NA PBac{WH}hephf07076 NA PBac{WH}hephf07875 NA insertion of enhancer trap binary system Mi{ET1}hephMB01096 No P{GawB}heph9.189 No P{GawB}heph18.104 No P{GawB}hephNP3019 No P{GawB}hephNP6506 No P{GawB}hephNP6544 No P{GawB}hephNP6560 No P{GawB}hephNP7447 No P{GawB}hephNP7516 No PBac{GAL4D,EYFP}hephPL00536 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
mRNA 3'-UTR binding inferred from direct assay (Besse et al., 2009) translation repressor activity, nucleic acid binding inferred from mutant phenotype (Besse et al., 2009)
Biological Process
CV term Evidence References
imaginal disc-derived wing margin morphogenesis inferred from mutant phenotype (Dansereau et al., 2002) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Dansereau et al., 2002) negative regulation of oskar mRNA translation inferred from mutant phenotype (Besse et al., 2009) Notch signaling pathway inferred from mutant phenotype (Dansereau et al., 2001) oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (Besse et al., 2009) regulation of response to DNA damage stimulus inferred from genetic interaction with lok (Park and Song, 2008) response to DNA damage stimulus inferred from mutant phenotype (Park and Song, 2008) spermatid development inferred from mutant phenotype (Castrillon et al., 1993, Robida and Singh, 2003) sperm individualization inferred from mutant phenotype (Robida et al., 2010)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Besse et al., 2009) ribonucleoprotein complex inferred from direct assay (Besse et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) poly-pyrimidine tract binding inferred from sequence or structural similarity with NCBI:NP_002810 (Mount and Salz, 2000) non-traceable author statement (Standiford, 1999.12.3, Dansereau, 2001.10.19)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred from sequence or structural similarity with NCBI:NP_002810 (Mount and Salz, 2000)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR006536 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions heph allele Gene References heph03429 fng (Dansereau et al., 2002) unspecified ct (Krupp et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71508 DroID - A comprehensive database of gene and protein interactions. • FBgn0011224 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48571
Orthologs
OrthoDB Orthologs (57) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VDQJ2 Dipteran inclusive ortholog search EOG64BB9F Insect inclusive ortholog search EOG6HDRPM Arthropod inclusive ortholog search EOG6HT779 Metazoa inclusive ortholog search EOG6DRP87
Orthologs in Drosophila Species (EOG6VDQJ2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\heph     Drosophila simulans   Dsim\GD16206 Y   Drosophila sechellia   Dsec\GM16408 Y   Drosophila erecta   Dere\GG11844 Y   Drosophila yakuba   Dyak\GE23291 Y   Drosophila ananassae   Dana\GF17502 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15927 Y   Drosophila persimilis   Dper\GL24102 Y   Drosophila willistoni   Dwil\GK10936 Y   Drosophila virilis   Dvir\GJ22800 Y   Drosophila mojavensis   Dmoj\GI22798 Y   Drosophila grimshawi   Dgri\GH17472 Y
Orthologs in non-Drosophila Dipterans (EOG64BB9F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013723   Anopheles gambiae Malaria mosquito  Agam\AGAP003945   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006979   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000588   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006978
Orthologs in non-Dipteran Insects (EOG6HDRPM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48838   Apis mellifera Western honey bee  Amel\GB48840   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016312   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19104   Atta cephalotes Leafcutter ant  Acep\ACEP19705   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13904   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17865   Linepithema humile Argentine ant  Lhum\LH24461   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24981   Solenopsis invicta Red fire ant  Sinv\SINV15195   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004037   Bombyx mori Silkmoth  Bmor\BGIBMGA004733   Bombyx mori Silkmoth  Bmor\BGIBMGA004732   Pediculus humanus Human body louse  Phum\PHUM576170   Tribolium castaneum Red flour beetle  Tcas\TC011728
Orthologs in non-Insect Arthropods (EOG6HT779)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Wnt7a   Ixodes scapularis Deer tick  Isca\ISCW018130
Orthologs in non-Arthropod Metazoa (EOG6DRP87)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012409gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000961gn   Danio rerio Zebrafish  Drer\ptbp1a   Danio rerio Zebrafish  Drer\ptbp2   Danio rerio Zebrafish  Drer\ptbp1b   Danio rerio Zebrafish  Drer\ptbp2a   Danio rerio Zebrafish  Drer\si:dkey-27p1.2   Xenopus tropicalis Western clawed frog  Xtro\rod1   Xenopus tropicalis Western clawed frog  Xtro\ptbp2   Gallus gallus Domestic chicken  Ggal\PTBP1   Gallus gallus Domestic chicken  Ggal\PTBP2   Gallus gallus Domestic chicken  Ggal\ROD1   Mus musculus House mouse  Mmus\Ptbp1   Mus musculus House mouse  Mmus\ENSMUSG00000028382   Mus musculus House mouse  Mmus\Ptbp2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027820   Rattus norvegicus Norway rat  Rnor\Ptbp1   Rattus norvegicus Norway rat  Rnor\Ptbp2   Rattus norvegicus Norway rat  Rnor\Smptb   Rattus norvegicus Norway rat  Rnor\Ptbp3   Homo sapiens Human  Hsap\PTBP2   Homo sapiens Human  Hsap\PTBP1   Homo sapiens Human  Hsap\PTBP3
Human Orthologs (3)
Gene OMIM HGNC Hsap\PTBP2     Hsap\PTBP1     Hsap\PTBP3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16206 Drosophila sechellia Dsec\GM16408 Drosophila erecta Dere\GG11844 Drosophila yakuba Dyak\GE23291 Drosophila ananassae Dana\GF17502 Drosophila pseudoobscura pseudoobscura Dpse\GA15927 Drosophila persimilis Dper\GL24102 Drosophila willistoni Dwil\GK10936 Drosophila virilis Dvir\GJ22800 Drosophila mojavensis Dmoj\GI22798 Drosophila grimshawi Dgri\GH17472
Stocks & Reagents
Stocks Listed in FlyBase ( 71 )
Harvard	- P{XP}hephd04828 - P{XP}hephd05595 - P{XP}hephd06250 - P{XP}hephd08300 - P{XP}hephd09267 - P{XP}hephd09905 - PBac{PB}hephc00105 - PBac{PB}hephc00135 - PBac{PB}hephc00583 - PBac{PB}hephc00594 - PBac{PB}hephc00841 - PBac{PB}hephc00864
	More stocks available...
Genomic Clones ( 2 )
	BACR16F16 BACR21I23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 499 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP15289 LD03185 LD04329 LD11808 SD22984
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06424 AT19521 GH17441 GH18414 GH19803 GM10107 GM21379 HL05832 LD02515 LD02583 LD03431 LD05207 LD08026 LD11010 LD13032 LD14764 LD17948 LD20777 LD27521 LD40283 LD44804 LP10204 RE03336 RE04481 RE10393 RE15258 RE17617 RE37390 RE39513 RE44482 RE47457 RE48295 RE48369 RE48795 RE56755 RE61675 RE65068 RE73244 RH04324 RH04390 RH07193 RH10576 RH10904 RH11852 RH12090 RH13479 RH13709 RH16019 RH16209 RH17093 RH17215 RH17293 RH17409 RH18095 RH20543 RH21653 RH21844 RH22132 RH22177 RH22556 RH22735 RH26972 RH29568 RH29611 RH29690 RH29717 RH30058 RH30182 RH30333 RH30767 RH31611 RH31616 RH32493 RH33778 RH37622 RH38076 RH39930 RH42014 RH42077 RH42327 RH42543 RH42985 RH44978 RH45176 RH46016 RH46595 RH46639 RH47060 RH47229 RH47315 RH47775 RH48091 RH49746 RH50730 RH51215 RH51705 RH51995 RH52448 RH52603 RH54383 RH54653 RH55168 RH55173 RH55446 RH55941 RH56741 RH56809 RH56819 RH56839 RH56978 RH57786 RH57944 RH58019 RH58044 RH58239 RH59131 RH60268 RH60713 RH61408 RH61433 RH61478 RH61508 RH61578 RH61691 RH62378 RH63266 RH64377 RH65659 RH66252 RH66273 RH66292 RH67049 RH67365 RH67395 RH67957 RH68761 RH68859 RH69071 RH69793 RH71145 RH73083 RH74330 SD02265 SD16292 SD18363 SD25304
Other clones	501 557 10107 10951 11231 13569 13573 18100 19292 29599 29803 29831 32030 37531 40215 43829 46506 47039 53187 54094 54951 55668 55784 58075 59079 60476 61338 65682 70315 70352 71236 71819 72961 73908 74710 80659 81744 98332 100257 102484 105957 106676 107945 107949 108137 109222 118421 123566 147628 148692 160260 173214 174392 174725 179662 182081 183124 190017 192321 194626 214215.25 214383.62 214411.32 214415.33 214435.30 273722 274216 282281 AI124308 CK01.11A.E12 CK01.12B.E1 CK01.21D.G9 CK01.28B.A2 CK01.30D.D10 CK01.36A.A10 CK01.63B.F5 CK01.70B.D10 CK01.73C.D8 CK01.81B.E12 CK01.83B.D7 CK01.84A.H4 CK01.85C.H10 CK01.88C.D4 CK01.91D.G1 CK01.96D.H12 CK01.97D.B12 CK01.100D.H11 CK01.105C.E11 CK01.110D.E3 CK01.112A.E9 CK01.112B.A10 CK01.118A.E11 CK01.124D.F8 CK01.128C.C10 CK01.128C.G8 CK01.132B.A4 CK01.169B.F10 CK00330 CK01023 CK01258 CK01331 CK01336 CK01363 CK01421 CK01448 CK01456 CK01462 CK01603 CK01617 CK01634 CK01718 CK01792 CK01833 CK01890 CK01958 CK02010 CK02026 CK02089 CK02102 CK02134 CK02139 CK02311 CK02315 CK02322 CK02429 CK02526 CK02564 CK02584 CK02648 Dmel_dig_016636_0682_1886 Dmel_dig_016705_0710_3072 Dmel_neb_008145_0339_0465 EC14884 EC41454 EK012852 EK019007 EK027108 EK031006 EK031312 EK032025 EK034826 EK043120 EK047843 EK049563 EK050218 EK050409 EK051618 EK051838 EK053809 EK055947 EK057948 EK058252 EK058646 EK059016 EK061807 EK062752 EK063402 EK066416 EK066962 EK067663 EK069746 EK071825 EK073259 EK074745 EK075064 EK075111 EK077604 EK082259 EK083914 EK085812 EK087859 EK088318 EK088356 EK089024 EK089958 EK090715 EK092228 EK094856 EK095134 EK095603 EK099741 EK101618 EK104936 EK105342 EK110026 EK111933 EK112136 EK113540 EK115531 EK115537 EK116527 EK117157 EK117938 EK119258 EK121214 EK121312 EK122062 EK126204 EK129929 EK130147 EK131158 EK133510 EK136538 EK139237 EK139758 EK142348 EK143801 EK145429 EK147049 EK148608 EK149108 EK150160 EK150812 EK154064 EK154330 EK159214 EK160129 EK160358 EK161453 EK165022 EK165338 EK165624 EK165964 EK170064 EK171219 EK173958 EK178057 EK178259 EK182743 EK182949 EK183856 EK183952 EK184711 EK186156 EK187045 EK190808 EK191027 EK193153 EK194453 EK194822 EK197709 EK198049 EK198161 EK198534 EK200153 EK200452 EK201106 EK203155 EK205033 EK206320 EK206804 EK207149 EK209011 EK213944 EK215242 EK215309 EK215732 EK217506 EK219351 EK220858 EK221844 EK222931 EK225919 EK227244 EK227895 EK228028 EK231315 EK234730 EK236026 EK236034 EK237324 EK240954 EK241147 EK243327 EK243447 EK244264 EK246561 EK246762 EK253707 EK255034 EK258226 EK263629 EK264714 EK265613 EK267760 EK272756 EK277553 EK278462 EK279116 EK284041 EK286748 EK289455 EK289458 EK291554 EK292041 EK296753 EK301646 EK301716 EK303642 EK303701 EK304364 EK308245 EN02064 EN15045 EP00315 EP00917 EP01012 EP02335 EP02341 EP04728 EP04754 EP05039 EP05547 EP07649 EP08720 EP08834 EP08943 EP09905 EP10203 EP10234 EP10464 EP10540 EP11254 EP11446 EP11516 EP11550 EP11622 EP11914 EP12401 EP13133 EP13602 EP14842 EP16650 EP17315 EP17856 EP17860 EP18944 EP19157 EP19847 EP19922 EP21033 EP21045 FGA011F05 FGH106D08 FGM209B11 FGM214G12 IP15489 IP15589
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011224 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48571
Antibody Information
	polyclonal (Robida et al., 2010, Besse et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ema l(3)03429 (Dansereau, 2001.3.6)
Source for database merge of	Source for merge of: heph ema (Dansereau et al., 2002) Source for merge of: heph PTB (FlyBase, 1996-) Source for merge of: PTB CG2094 (Whitfield, 2000.5.16) Source for merge of: PTB CG2290 (Dansereau, 2001.3.6)
Additional comments	Annotations CG2094, CG2290 merged as CG31000 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of heph PTB was sequence comparison (date:011101). (Dansereau, 2001.3.6, FlyBase, 1996-)
Other Comments
	heph function is essential for spermatogenesis during spermatid differentiation. (Robida and Singh, 2003) Loss of heph in genetic mosaics induces ectopic wing margin. (Dansereau et al., 2002) heph is required for refinement of N activity at the D/V boundary of the wing. (Dansereau et al., 2001) Mutant phenotypes are consistent with the activation of N signaling. (Dansereau et al., 2001) Postmeiotic differentiation defect. (Castrillon et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079964 NM_170581 NM_170582 NM_176596 NM_176597 NM_176598 NM_176599 NM_176600 NM_176601 NM_176602 NM_176603 NM_001104522 NM_001104523 NM_001104524 NM_001170316 NM_001170317 NM_001170318 NM_001170319 NM_001170320 NM_001170321 NM_001170322 NM_001170323 NM_001260469 NM_001260470 RefSeq (Proteins) • NP_524703 NP_733460 NP_733461 NP_788773 NP_788774 NP_788775 NP_788776 NP_788777 NP_788778 NP_788779 NP_788780 NP_001097992 NP_001097993 NP_001097994 NP_001163787 NP_001163788 NP_001163789 NP_001163790 NP_001163791 NP_001163792 NP_001163793 NP_001163794 NP_001247398 NP_001247399 DDBJ / EMBL / GenBank • AA201355 AA202699 AAF22979 AAF57208 AAL14775 AAL27010 AAL39463 AAL57860 AAM48477 AAN14296 AAN14297 AAO41620 AAO41621 AAO41622 AAO41623 AAO41624 AAO41625 AAO41626 AAO41627 AAT72299 ABW08816 ABW08817 ABW08818 ACZ95080 ACZ95081 ACZ95082 ACZ95083 ACZ95084 ACZ95085 ACZ95086 ACZ95087 AF211191 AF373596 AF436844 AF455053 AFH06715 AFH06716 AI387029 AQ026438 AW942041 AY052367 AY069318 AY118448 AY628765 BI640181 CL943562 CZ466145 CZ466200 CZ466226 CZ466234 CZ466280 CZ466302 CZ466308 CZ466309 CZ466574 CZ466679 CZ466758 CZ466759 CZ466774 CZ466799 CZ466876 CZ467131 CZ467223 CZ467244 CZ467246 CZ467291 CZ467292 CZ467315 CZ467481 CZ469436 CZ469917 CZ470085 CZ470121 CZ470534 CZ471014 CZ471262 CZ472056 CZ472224 CZ474158 CZ474624 CZ474625 CZ474626 CZ474718 CZ474719 CZ475005 CZ475006 CZ475149 CZ477005 CZ477108 CZ478315 CZ478792 CZ479451 CZ481144 CZ481246 CZ481330 CZ483022 CZ483620 CZ483621 CZ483720 CZ484010 CZ484513 CZ484514 CZ485140 CZ486163 CZ487655 CZ489693 CZ489843 CZ489844 G00761 Entrez Gene - A searchable database of RefSeq genes. • 48571 UniProtKB/TrEMBL • A8JRI1 E1JJ45 Q3T7F7 Q7KES3 Q7KRS7 Q8IMF8 Q8MT11 Q8T0H5 Q8WR53 Q95UI6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) HnRNP-L/PTB/hephaestus splicing factor (IPR006536) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD03185 LD04329
Linkouts
	BioGRID - A database of protein and genetic interactions • 71508 DroID - A comprehensive database of gene and protein interactions. • FBgn0011224 DRSC - Results from RNAi screens. • FBgn0011224 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011224 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31000-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011224 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48571 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/hepha1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48571 modMine - Data generated by the modENCODE project. • FBgn0011224
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	CG2094 (Dansereau, 2001.3.6, Mount and Salz, 2000, Whitfield, 2000.5.16, Whitfield, 2000.5.16, ) CG2290 (Norga et al., 2003, ) CG31000 (Metaxakis et al., 2005, Besse et al., 2009, Perkins et al., 2009.3.31, Montagne et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dmPTB (Robida and Singh, 2003, Robida et al., 2010) dPTB (Yang et al., 2009) ema (Dansereau, 2001.3.6, Dansereau et al., 2001, ) heph (Cook et al., 2008.12.28, Sofola et al., 2007, Buszczak et al., 2007, Dorus et al., 2006, Kankel et al., 2007, Hilgers et al., 2011, Besse et al., 2009, Dorus et al., 2006, Hilgers et al., 2012, Mourikis et al., 2010, Beltran et al., 2007, Owald et al., 2010, Wasbrough et al., 2010, Hazelett et al., 2009, Seong et al., 2011, Luo et al., 2011, Smibert et al., 2012, Japanese National Institute of Genetics, 2012.5.21) HEPH (Sofola et al., 2007) Heph (McDermott et al., 2012) l(3)03429 (Beaton, 1999.12.12, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(3)j11B9   PTB (Robida and Singh, 2003, Davis et al., 2002, Dansereau, 2001.3.6, Lasko, 2000, Standiford, 1999.12.3, McDermott et al., 2012, Ezzeddine et al., 2011, Besse et al., 2008, Vargas et al., 2011) Ptb (Davis et al., 2002, Davis et al., 2001, Leatherman and Dinardo, 2010) ptb (Dansereau et al., 2001, Besse et al., 2009)
Name Synonym	ectopic margin (Dansereau et al., 2001) hephaestus (Castrillon et al., 1993, Burnette et al., 2005, Kankel et al., 2007, Besse et al., 2009, Montagne et al., 2010, Mourikis et al., 2010, Wasbrough et al., 2010, Dalton et al., 2010, Eddison et al., 2012, Park and Song, 2008) Hephaestus (Zhang et al., 2011) Polypyrimidine Tract Binding protein (Standiford, 1999.12.3, Besse et al., 2008) polypyrimidine tract binding protein (Ezzeddine et al., 2011) polypyrimidine tract-binding protein (Besse et al., 2009)
Secondary FlyBase IDs
	FBgn0010798 FBgn0011433 FBgn0029138 FBgn0039884 FBgn0039885 FBgn0051000
References ( 93 )
Generate a list of	All references relating to this gene ( 93 )
List References by type	Research paper  ( 43 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 28 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 10 )
	Eddison et al., 2012, PLoS ONE 7(12): e51684 A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. [FBrf0220425] Hilgers et al., 2012, Genes Dev. 26(20): 2259--2264 ELAV mediates 3' UTR extension in the Drosophila nervous system. [FBrf0219699] McDermott et al., 2012, Biol. Open 1(5): 488--497 Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. [FBrf0218722] Smibert et al., 2012, Cell Rep. 1(3): 277--289 Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila. [FBrf0218523] Ezzeddine et al., 2011, Mol. Cell. Biol. 31(2): 328--341 A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation. [FBrf0212592] Hilgers et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(38): 15864--15869 Neural-specific elongation of 3' UTRs during Drosophila development. [FBrf0215804] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Vargas et al., 2011, Cell 147(5): 1054--1065 Single-molecule imaging of transcriptionally coupled and uncoupled splicing. [FBrf0217264] Zhang et al., 2011, J. Exp. Biol. 214(23): 4021--4029 Divergent transcriptomic responses to repeated and single cold exposures in Drosophila melanogaster. [FBrf0216629] Show all research papers ...