Myosin VI, Mhc95F, 95F myosin, MyoVI, 95F
Drosophila myosin VI, a pointed end directed molecular motor - involved in asymmetric cell division - regulates actin dynamics during sperm individualization
Please see the JBrowse view of Dmel\jar for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Gene model reviewed during 6.02
4.7, 4.5-4.7 (northern blot)
1268, 1253, 1078 (aa); 145, 140, 120 (kD)
The jar protein isoforms differ only at the carboxy-terminal end. All are related to other myosin proteins in the head region. No sequences in the database are related to the tail regions.
The jar protein isoforms differ only at the
carboxy-terminal end. All are related to other myosin proteins in the head
region. No sequences in the database are related to the tail regions.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jar using the Feature Mapper tool.
jar protein is observed in a punctate pattern throughout the cortical cytoplasm.
GBrowse - Visual display of RNA-Seq signals
View Dmel\jar in GBrowse 23-84
3-82.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: jar CG5695
Source for merge of: jar Mhc95F
didum acts to interrupt mitochondrial transport on microtubules to decrease the duty cycle and perhaps facilitate docking in retrograde transport.
jar is necessary for dorsal closure.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
jar is necessary for basal protein targeting and spindle orientation in dividing embryonic neuroblasts.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
jar is necessary for border follicle cell migration.
jar is required for both imaginal disc and egg chamber morphogenesis.
jar is essential for individualisation of spermatids during spermatogenesis.
jar protein is involved in intra- and intercellular transport during oogenesis.
jar associates with cytoplasmic particles that undergo cell cycle- dependent translocations. In interphase these particles are in cytoplasmic domains surrounding the nuclei near the syncytial blastoderm, during mitosis the particles associate with transient actin rich membrane invaginations that separate neighbouring nuclei. Time lapse computational optical sectioning microscopy has shown directed transport of the particles. The transport is actin based, ATP-dependent and is disrupted by a jar specific antibody.
Actin based, ATP-dependent linear transport of cytoplasmic particles in syncytial blastoderm embryos can be visualised by antibodies and is catalysed by the unconventional myosin jar.
Postmeiotic differentiation defect.
jar encodes a novel class of MHC, first detected as a 140kD actin binding protein by Miller et al., (J. Cell Biol. 109: 2963-2975) by their 3C7 monoclonal antibody. Transcription and splicing patterns are complex, with probably four protein isoforms.
