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Gene Dmel\ox

General Information
Symbol	Dmel\ox	Species	D. melanogaster
Name	oxen	Annotation symbol	CG8764
Feature type	protein_coding_gene	FlyBase ID	FBgn0011227
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	QCR9
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49C2-49C2	Sequence location	2R:8,644,638..8,645,034 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene oxen is referred to in FlyBase by the symbol Dmel\ox (CG8764, FBgn0011227). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquinol-cytochrome-c reductase activity. There is experimental evidence that it is involved in the biological process: spermatid development. 11 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome b-c1 complex subunit 9. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1633973_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ox. Gene sequence location is 2R:8644638..8645034.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49C2-49C2   Limits computationally determined from genome sequence between P{EP}AmphEP2175&P{lacW}spt4k05316 and P{PZ}ox1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49C-49C     (Benevolenskaya, 1997.8.7) 49C1-49C4   (determined by in situ hybridisation)   (Spradling et al., 1999) 49C1-49C4     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ox for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ox-RA FBtr0087861  NM_057637   331   55
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ox-PA   FBpp0086974   6.3   55   10.19     NP_476985   AAF58459
Additional Polypeptide Data & Comments
Reported size (kDa)	55 (aa); 6.6 (kD predicted) (Frolov et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b-c1 complex subunit 9 (IPR008027) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08764
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58459   AC007453   AC091499   AF017783 AAD28637   AI063477   AI403164   AQ026399   AY071727 AAL49349   AY232096   BE975912   BE977311   BI615124   BT058010   CL610142   CO275260   CZ470275   EC231927   EL874283   EV579541   EV585088   EV588452   EV592831   EV593558   EV600122
UniProtKB/Swiss-Prot	Q9XY35
UniProtKB/TrEMBL	Q8SY81
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 11   organism | ubiquitous   (Frolov et al., 2000) embryonic stage 13   amnioserosa   (Frolov et al., 2000) embryonic stage 13 -- 17   embryonic/larval midgut   (Frolov et al., 2000) embryonic stage 16 -- 17   embryonic midgut chamber   (Frolov et al., 2000) Comment:all four midgut chambers
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    701.7 Larval Midgut    1297.9 Larval Hindgut    1807.1 Larval Malpighian Tubules    912.3 Larval Fat Body    389.2 Larval Salivary Gland    998.4 Larval Trachea    826.225 Larval Carcass    1935.85 Adult Head    1705.6 Adult Eye    1525.15 Adult Brain    1209.4 Adult Thoracic-Abdominal Ganglion    1365.4 Adult Crop    1514.9 Adult Midgut    1353 Adult Hindgut    2057.7 Adult Malpighian Tubules    1313.1 Adult Fat Body    1985.2 Adult Salivary Gland    2078.9 Adult Heart    2096.775 Adult VirginFemale Spermatheca    2181.2 Adult InseminatedFemale Spermatheca    1944.2 Adult Ovary    571.5 Adult Testis    873 Adult Male Accessory Gland    660.2 Adult Carcass    2943.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (701.7) Larval Midgut  (1297.9) Larval Hindgut  (1807.1) Larval Malpighian Tubules  (912.3) Larval Fat Body    389.2 Larval Salivary Gland  (998.4) Larval Trachea  (826.225) Larval Carcass  (1935.85) Adult Head  (1705.6) Adult Eye  (1525.15) Adult Brain  (1209.4) Adult Thoracic-Abdominal Ganglion  (1365.4) Adult Crop  (1514.9) Adult Midgut  (1353) Adult Hindgut  (2057.7) Adult Malpighian Tubules  (1313.1) Adult Fat Body  (1985.2) Adult Salivary Gland  (2078.9) Adult Heart  (2096.775) Adult VirginFemale Spermatheca  (2181.2) Adult InseminatedFemale Spermatheca  (1944.2) Adult Ovary  (571.5) Adult Testis  (873) Adult Male Accessory Gland  (660.2) Adult Carcass  (2943.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    701.7 Larval Midgut  (1297.9) Larval Hindgut  (1807.1) Larval Malpighian Tubules    912.3 Larval Fat Body    389.2 Larval Salivary Gland    998.4 Larval Trachea    826.225 Larval Carcass  (1935.85) Adult Head  (1705.6) Adult Eye  (1525.15) Adult Brain  (1209.4) Adult Thoracic-Abdominal Ganglion  (1365.4) Adult Crop  (1514.9) Adult Midgut  (1353) Adult Hindgut  (2057.7) Adult Malpighian Tubules  (1313.1) Adult Fat Body  (1985.2) Adult Salivary Gland  (2078.9) Adult Heart  (2096.775) Adult VirginFemale Spermatheca  (2181.2) Adult InseminatedFemale Spermatheca  (1944.2) Adult Ovary    571.5 Adult Testis    873 Adult Male Accessory Gland    660.2 Adult Carcass  (2943.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    701.7 Larval Midgut    1297.9 Larval Hindgut    1807.1 Larval Malpighian Tubules    912.3 Larval Fat Body    389.2 Larval Salivary Gland    998.4 Larval Trachea    826.225 Larval Carcass    1935.85 Adult Head    1705.6 Adult Eye    1525.15 Adult Brain    1209.4 Adult Thoracic-Abdominal Ganglion    1365.4 Adult Crop    1514.9 Adult Midgut    1353 Adult Hindgut    2057.7 Adult Malpighian Tubules    1313.1 Adult Fat Body    1985.2 Adult Salivary Gland    2078.9 Adult Heart    2096.775 Adult VirginFemale Spermatheca    2181.2 Adult InseminatedFemale Spermatheca    1944.2 Adult Ovary    571.5 Adult Testis    873 Adult Male Accessory Gland    660.2 Adult Carcass    2943.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    701.7 Larval Midgut    1297.9 Larval Hindgut    1807.1 Larval Malpighian Tubules    912.3 Larval Fat Body    389.2 Larval Salivary Gland    998.4 Larval Trachea    826.225 Larval Carcass    1935.85 Adult Head    1705.6 Adult Eye    1525.15 Adult Brain    1209.4 Adult Thoracic-Abdominal Ganglion    1365.4 Adult Crop    1514.9 Adult Midgut    1353 Adult Hindgut    2057.7 Adult Malpighian Tubules    1313.1 Adult Fat Body    1985.2 Adult Salivary Gland    2078.9 Adult Heart    2096.775 Adult VirginFemale Spermatheca    2181.2 Adult InseminatedFemale Spermatheca    1944.2 Adult Ovary    571.5 Adult Testis    873 Adult Male Accessory Gland    660.2 Adult Carcass    2943.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  701.7 Larval Midgut  (1297.9) Larval Hindgut  (1807.1) Larval Malpighian Tubules  (912.3) Larval Fat Body    389.2 Larval Salivary Gland  (998.4) Larval Trachea  (826.225) Larval Carcass  (1935.85) Adult Head  (1705.6) Adult Eye  (1525.15) Adult Brain  (1209.4) Adult Thoracic-Abdominal Ganglion  (1365.4) Adult Crop  (1514.9) Adult Midgut  (1353) Adult Hindgut  (2057.7) Adult Malpighian Tubules  (1313.1) Adult Fat Body  (1985.2) Adult Salivary Gland  (2078.9) Adult Heart  (2096.775) Adult VirginFemale Spermatheca  (2181.2) Adult InseminatedFemale Spermatheca  (1944.2) Adult Ovary  571.5 Adult Testis  (873) Adult Male Accessory Gland  660.2 Adult Carcass  (2943.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    701.7 Larval Midgut  1297.9 Larval Hindgut  (1807.1) Larval Malpighian Tubules    912.3 Larval Fat Body    389.2 Larval Salivary Gland    998.4 Larval Trachea    826.225 Larval Carcass  (1935.85) Adult Head  1705.6 Adult Eye  1525.15 Adult Brain  1209.4 Adult Thoracic-Abdominal Ganglion  1365.4 Adult Crop  1514.9 Adult Midgut  1353 Adult Hindgut  (2057.7) Adult Malpighian Tubules  1313.1 Adult Fat Body  (1985.2) Adult Salivary Gland  (2078.9) Adult Heart  (2096.775) Adult VirginFemale Spermatheca  (2181.2) Adult InseminatedFemale Spermatheca  (1944.2) Adult Ovary    571.5 Adult Testis    873 Adult Male Accessory Gland    660.2 Adult Carcass  (2943.6) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    701.7 Larval Midgut    1297.9 Larval Hindgut    1807.1 Larval Malpighian Tubules    912.3 Larval Fat Body    389.2 Larval Salivary Gland    998.4 Larval Trachea    826.225 Larval Carcass    1935.85 Adult Head    1705.6 Adult Eye    1525.15 Adult Brain    1209.4 Adult Thoracic-Abdominal Ganglion    1365.4 Adult Crop    1514.9 Adult Midgut    1353 Adult Hindgut    2057.7 Adult Malpighian Tubules    1313.1 Adult Fat Body    1985.2 Adult Salivary Gland    2078.9 Adult Heart    2096.775 Adult VirginFemale Spermatheca    2181.2 Adult InseminatedFemale Spermatheca    1944.2 Adult Ovary    571.5 Adult Testis    873 Adult Male Accessory Gland    660.2 Adult Carcass    2943.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1705.6   NA  Eye    1525.15   NA  Brain    1209.4   701.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1365.4   NA  Crop    1514.9   1297.9  Midgut    1353   1807.1  Hindgut    2057.7   912.3  Malpighian Tubules    1313.1   389.2  Fat Body    1985.2   998.4  Salivary Gland    2078.9   NA  Heart    2096.775   826.225  Trachea    NA   NA  VirginFemale Spermatheca    2181.2   NA  InseminatedFemale Spermatheca    1944.2   NA  Ovary    571.5   NA  Testis    873   NA  Male Accessory Gland    660.2   1935.85  Carcass    2943.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    25 central nervous system, pupae P8    53 head, virgin 1-day female    117 head, virgin 4-day female    51 head, virgin 20-day female    37 head, mated 1-day female    103 head, mated 4-day female    81 head, mated 20-day female    44 head, mated 1-day male    114 head, mated 4-day male    123 head, mated 20-day male    120 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    117 digestive system, 4-day adult    102 digestive system, 20-day adult    53 fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8    68 carcass, larvae L3 wandering    26 carcass, 1-day adult    308 carcass, 4-day adult    229 carcass, 20-day adult    120 ovary, virgin 4-day female    29 ovary, mated 4-day female    36 testis, mated 4-day male    114 accessory gland, mated 4-day male    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3    25 central nervous system, pupae P8  (53) head, virgin 1-day female  (117) head, virgin 4-day female  (51) head, virgin 20-day female  (37) head, mated 1-day female  (103) head, mated 4-day female  (81) head, mated 20-day female  (44) head, mated 1-day male  (114) head, mated 4-day male  (123) head, mated 20-day male  (120) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering  (31) digestive system, 1-day adult  (117) digestive system, 4-day adult  (102) digestive system, 20-day adult  (53) fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8  (68) carcass, larvae L3 wandering  26 carcass, 1-day adult  (308) carcass, 4-day adult  (229) carcass, 20-day adult  (120) ovary, virgin 4-day female  (29) ovary, mated 4-day female  (36) testis, mated 4-day male  (114) accessory gland, mated 4-day male  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    25 central nervous system, pupae P8    53 head, virgin 1-day female  (117) head, virgin 4-day female    51 head, virgin 20-day female    37 head, mated 1-day female  103 head, mated 4-day female    81 head, mated 20-day female    44 head, mated 1-day male  (114) head, mated 4-day male  (123) head, mated 20-day male  (120) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    31 digestive system, 1-day adult  (117) digestive system, 4-day adult  102 digestive system, 20-day adult    53 fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8    68 carcass, larvae L3 wandering    26 carcass, 1-day adult  (308) carcass, 4-day adult  (229) carcass, 20-day adult  (120) ovary, virgin 4-day female    29 ovary, mated 4-day female    36 testis, mated 4-day male  (114) accessory gland, mated 4-day male    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    25 central nervous system, pupae P8    53 head, virgin 1-day female    117 head, virgin 4-day female    51 head, virgin 20-day female    37 head, mated 1-day female    103 head, mated 4-day female    81 head, mated 20-day female    44 head, mated 1-day male    114 head, mated 4-day male    123 head, mated 20-day male    120 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    117 digestive system, 4-day adult    102 digestive system, 20-day adult    53 fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8    68 carcass, larvae L3 wandering    26 carcass, 1-day adult    308 carcass, 4-day adult    229 carcass, 20-day adult    120 ovary, virgin 4-day female    29 ovary, mated 4-day female    36 testis, mated 4-day male    114 accessory gland, mated 4-day male    51 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    25 central nervous system, pupae P8    53 head, virgin 1-day female    117 head, virgin 4-day female    51 head, virgin 20-day female    37 head, mated 1-day female    103 head, mated 4-day female    81 head, mated 20-day female    44 head, mated 1-day male    114 head, mated 4-day male    123 head, mated 20-day male    120 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    117 digestive system, 4-day adult    102 digestive system, 20-day adult    53 fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8    68 carcass, larvae L3 wandering    26 carcass, 1-day adult    308 carcass, 4-day adult    229 carcass, 20-day adult    120 ovary, virgin 4-day female    29 ovary, mated 4-day female    36 testis, mated 4-day male    114 accessory gland, mated 4-day male    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3    25 central nervous system, pupae P8  (53) head, virgin 1-day female  (117) head, virgin 4-day female  (51) head, virgin 20-day female  (37) head, mated 1-day female  (103) head, mated 4-day female  (81) head, mated 20-day female  (44) head, mated 1-day male  (114) head, mated 4-day male  (123) head, mated 20-day male  (120) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering  31 digestive system, 1-day adult  (117) digestive system, 4-day adult  (102) digestive system, 20-day adult  (53) fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8  (68) carcass, larvae L3 wandering  26 carcass, 1-day adult  (308) carcass, 4-day adult  (229) carcass, 20-day adult  (120) ovary, virgin 4-day female  29 ovary, mated 4-day female  (36) testis, mated 4-day male  (114) accessory gland, mated 4-day male  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    25 central nervous system, pupae P8    53 head, virgin 1-day female  117 head, virgin 4-day female    51 head, virgin 20-day female    37 head, mated 1-day female  103 head, mated 4-day female    81 head, mated 20-day female    44 head, mated 1-day male  114 head, mated 4-day male  123 head, mated 20-day male  120 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    31 digestive system, 1-day adult  117 digestive system, 4-day adult  102 digestive system, 20-day adult    53 fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8    68 carcass, larvae L3 wandering    26 carcass, 1-day adult  (308) carcass, 4-day adult  (229) carcass, 20-day adult  120 ovary, virgin 4-day female    29 ovary, mated 4-day female    36 testis, mated 4-day male  114 accessory gland, mated 4-day male    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    25 central nervous system, pupae P8    53 head, virgin 1-day female    117 head, virgin 4-day female    51 head, virgin 20-day female    37 head, mated 1-day female    103 head, mated 4-day female    81 head, mated 20-day female    44 head, mated 1-day male    114 head, mated 4-day male    123 head, mated 20-day male    120 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    117 digestive system, 4-day adult    102 digestive system, 20-day adult    53 fat body, larvae L3 wandering    15 fat body, white prepupae    15 fat body, pupae P8    68 carcass, larvae L3 wandering    26 carcass, 1-day adult    308 carcass, 4-day adult    229 carcass, 20-day adult    120 ovary, virgin 4-day female    29 ovary, mated 4-day female    36 testis, mated 4-day male    114 accessory gland, mated 4-day male    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    119 embryo 02-04hr    126 embryo 04-06hr    167 embryo 06-08hr    175 embryo 08-10hr    205 embryo 10-12hr    312 embryo 12-14hr    231 embryo 14-16hr    172 embryo 16-18hr    321 embryo 18-20hr    292 embryo 20-22hr    420 embryo 22-24hr    434 larva L1    567 larva L2    567 larva L3 12hr old    458 larva L3 puffstage 1-2    341 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    159 white prepupae new    121 white prepupae 12hr    115 white prepupae 24hr    101 pupae 2d postWPP    258 pupae 3d postWPP    688 pupae 4d postWPP    767 adult male 01day    846 adult male 05day    649 adult male 30day    333 adult female 01day    582 adult female 05day    288 adult female 30day    216 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (119) embryo 02-04hr  (126) embryo 04-06hr  (167) embryo 06-08hr  (175) embryo 08-10hr  (205) embryo 10-12hr  (312) embryo 12-14hr  (231) embryo 14-16hr  (172) embryo 16-18hr  (321) embryo 18-20hr  (292) embryo 20-22hr  (420) embryo 22-24hr  (434) larva L1  (567) larva L2  (567) larva L3 12hr old  (458) larva L3 puffstage 1-2  (341) larva L3 puffstage 3-6  (159) larva L3 puffstage 7-9  (159) white prepupae new  (121) white prepupae 12hr  (115) white prepupae 24hr  (101) pupae 2d postWPP  (258) pupae 3d postWPP  (688) pupae 4d postWPP  (767) adult male 01day  (846) adult male 05day  (649) adult male 30day  (333) adult female 01day  (582) adult female 05day  (288) adult female 30day  (216) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (119) embryo 02-04hr  (126) embryo 04-06hr  (167) embryo 06-08hr  (175) embryo 08-10hr  (205) embryo 10-12hr  (312) embryo 12-14hr  (231) embryo 14-16hr  (172) embryo 16-18hr  (321) embryo 18-20hr  (292) embryo 20-22hr  (420) embryo 22-24hr  (434) larva L1  (567) larva L2  (567) larva L3 12hr old  (458) larva L3 puffstage 1-2  (341) larva L3 puffstage 3-6  (159) larva L3 puffstage 7-9  (159) white prepupae new  (121) white prepupae 12hr  (115) white prepupae 24hr  101 pupae 2d postWPP  (258) pupae 3d postWPP  (688) pupae 4d postWPP  (767) adult male 01day  (846) adult male 05day  (649) adult male 30day  (333) adult female 01day  (582) adult female 05day  (288) adult female 30day  (216) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    119 embryo 02-04hr    126 embryo 04-06hr    167 embryo 06-08hr    175 embryo 08-10hr    205 embryo 10-12hr    312 embryo 12-14hr    231 embryo 14-16hr    172 embryo 16-18hr    321 embryo 18-20hr    292 embryo 20-22hr    420 embryo 22-24hr    434 larva L1    567 larva L2    567 larva L3 12hr old    458 larva L3 puffstage 1-2    341 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    159 white prepupae new    121 white prepupae 12hr    115 white prepupae 24hr    101 pupae 2d postWPP    258 pupae 3d postWPP    688 pupae 4d postWPP    767 adult male 01day    846 adult male 05day    649 adult male 30day    333 adult female 01day    582 adult female 05day    288 adult female 30day    216 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    119 embryo 02-04hr    126 embryo 04-06hr    167 embryo 06-08hr    175 embryo 08-10hr    205 embryo 10-12hr    312 embryo 12-14hr    231 embryo 14-16hr    172 embryo 16-18hr    321 embryo 18-20hr    292 embryo 20-22hr    420 embryo 22-24hr    434 larva L1    567 larva L2    567 larva L3 12hr old    458 larva L3 puffstage 1-2    341 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    159 white prepupae new    121 white prepupae 12hr    115 white prepupae 24hr    101 pupae 2d postWPP    258 pupae 3d postWPP    688 pupae 4d postWPP    767 adult male 01day    846 adult male 05day    649 adult male 30day    333 adult female 01day    582 adult female 05day    288 adult female 30day    216 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (119) embryo 02-04hr  (126) embryo 04-06hr  (167) embryo 06-08hr  (175) embryo 08-10hr  (205) embryo 10-12hr  (312) embryo 12-14hr  (231) embryo 14-16hr  (172) embryo 16-18hr  (321) embryo 18-20hr  (292) embryo 20-22hr  (420) embryo 22-24hr  (434) larva L1  (567) larva L2  (567) larva L3 12hr old  (458) larva L3 puffstage 1-2  (341) larva L3 puffstage 3-6  (159) larva L3 puffstage 7-9  (159) white prepupae new  (121) white prepupae 12hr  (115) white prepupae 24hr  (101) pupae 2d postWPP  (258) pupae 3d postWPP  (688) pupae 4d postWPP  (767) adult male 01day  (846) adult male 05day  (649) adult male 30day  (333) adult female 01day  (582) adult female 05day  (288) adult female 30day  (216) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  119 embryo 02-04hr  126 embryo 04-06hr  (167) embryo 06-08hr  (175) embryo 08-10hr  (205) embryo 10-12hr  (312) embryo 12-14hr  (231) embryo 14-16hr  (172) embryo 16-18hr  (321) embryo 18-20hr  (292) embryo 20-22hr  (420) embryo 22-24hr  (434) larva L1  (567) larva L2  (567) larva L3 12hr old  (458) larva L3 puffstage 1-2  (341) larva L3 puffstage 3-6  (159) larva L3 puffstage 7-9  (159) white prepupae new  121 white prepupae 12hr  115 white prepupae 24hr  101 pupae 2d postWPP  (258) pupae 3d postWPP  (688) pupae 4d postWPP  (767) adult male 01day  (846) adult male 05day  (649) adult male 30day  (333) adult female 01day  (582) adult female 05day  (288) adult female 30day  (216) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    119 embryo 02-04hr    126 embryo 04-06hr    167 embryo 06-08hr    175 embryo 08-10hr    205 embryo 10-12hr    312 embryo 12-14hr    231 embryo 14-16hr    172 embryo 16-18hr    321 embryo 18-20hr    292 embryo 20-22hr    420 embryo 22-24hr    434 larva L1    567 larva L2    567 larva L3 12hr old    458 larva L3 puffstage 1-2    341 larva L3 puffstage 3-6    159 larva L3 puffstage 7-9    159 white prepupae new    121 white prepupae 12hr    115 white prepupae 24hr    101 pupae 2d postWPP    258 pupae 3d postWPP    688 pupae 4d postWPP    767 adult male 01day    846 adult male 05day    649 adult male 30day    333 adult female 01day    582 adult female 05day    288 adult female 30day    216 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    211 Schneider line 2 Sg4    180 embryonic 1182-4H    32 embryonic GM2    76 embryonic Kc167    66 embryonic S1    89 embryonic S3    115 leg disc CME L1    81 wing disc CME-W2    88 wing disc ML-DmD8    116 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    92 wing disc ML-DmD21    142 wing disc ML-DmD32    85 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    150 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    168 CNS ML-DmBG2-c2    87 tumorous blood cells mbn2    70 ovary fGS/OSS    30 ovary OSC    88 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (211) Schneider line 2 Sg4  (180) embryonic 1182-4H  (32) embryonic GM2  (76) embryonic Kc167  (66) embryonic S1  (89) embryonic S3  (115) leg disc CME L1  (81) wing disc CME-W2  (88) wing disc ML-DmD8  (116) wing disc ML-DmD9  (71) wing disc ML-DmD16-c3  (92) wing disc ML-DmD21  (142) wing disc ML-DmD32  (85) haltere disc ML-DmD17-c3  (97) eye-antennal disc ML-DmD11  (150) antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (108) CNS ML-DmBG1-c1  (168) CNS ML-DmBG2-c2  (87) tumorous blood cells mbn2  (70) ovary fGS/OSS  (30) ovary OSC  (88) ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (211) Schneider line 2 Sg4  (180) embryonic 1182-4H    32 embryonic GM2    76 embryonic Kc167    66 embryonic S1    89 embryonic S3  (115) leg disc CME L1    81 wing disc CME-W2    88 wing disc ML-DmD8  (116) wing disc ML-DmD9    71 wing disc ML-DmD16-c3    92 wing disc ML-DmD21  (142) wing disc ML-DmD32    85 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11  (150) antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (108) CNS ML-DmBG1-c1  (168) CNS ML-DmBG2-c2    87 tumorous blood cells mbn2    70 ovary fGS/OSS    30 ovary OSC    88 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    211 Schneider line 2 Sg4    180 embryonic 1182-4H    32 embryonic GM2    76 embryonic Kc167    66 embryonic S1    89 embryonic S3    115 leg disc CME L1    81 wing disc CME-W2    88 wing disc ML-DmD8    116 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    92 wing disc ML-DmD21    142 wing disc ML-DmD32    85 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    150 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    168 CNS ML-DmBG2-c2    87 tumorous blood cells mbn2    70 ovary fGS/OSS    30 ovary OSC    88 ovary OSS    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    211 Schneider line 2 Sg4    180 embryonic 1182-4H    32 embryonic GM2    76 embryonic Kc167    66 embryonic S1    89 embryonic S3    115 leg disc CME L1    81 wing disc CME-W2    88 wing disc ML-DmD8    116 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    92 wing disc ML-DmD21    142 wing disc ML-DmD32    85 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    150 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    168 CNS ML-DmBG2-c2    87 tumorous blood cells mbn2    70 ovary fGS/OSS    30 ovary OSC    88 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (211) Schneider line 2 Sg4  (180) embryonic 1182-4H  32 embryonic GM2  (76) embryonic Kc167  (66) embryonic S1  (89) embryonic S3  (115) leg disc CME L1  (81) wing disc CME-W2  (88) wing disc ML-DmD8  (116) wing disc ML-DmD9  (71) wing disc ML-DmD16-c3  (92) wing disc ML-DmD21  (142) wing disc ML-DmD32  (85) haltere disc ML-DmD17-c3  (97) eye-antennal disc ML-DmD11  (150) antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (108) CNS ML-DmBG1-c1  (168) CNS ML-DmBG2-c2  (87) tumorous blood cells mbn2  (70) ovary fGS/OSS  30 ovary OSC  (88) ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (211) Schneider line 2 Sg4  (180) embryonic 1182-4H    32 embryonic GM2    76 embryonic Kc167    66 embryonic S1    89 embryonic S3  115 leg disc CME L1    81 wing disc CME-W2    88 wing disc ML-DmD8  116 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    92 wing disc ML-DmD21  142 wing disc ML-DmD32    85 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11  (150) antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  108 CNS ML-DmBG1-c1  (168) CNS ML-DmBG2-c2    87 tumorous blood cells mbn2    70 ovary fGS/OSS    30 ovary OSC    88 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    211 Schneider line 2 Sg4    180 embryonic 1182-4H    32 embryonic GM2    76 embryonic Kc167    66 embryonic S1    89 embryonic S3    115 leg disc CME L1    81 wing disc CME-W2    88 wing disc ML-DmD8    116 wing disc ML-DmD9    71 wing disc ML-DmD16-c3    92 wing disc ML-DmD21    142 wing disc ML-DmD32    85 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    150 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    168 CNS ML-DmBG2-c2    87 tumorous blood cells mbn2    70 ovary fGS/OSS    30 ovary OSC    88 ovary OSS    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    18 heat shock, 4-day adult    209 Cadmium 50 mM 6 hrs, larvae L3    181 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    174 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    128 Ethanol 2.5% 3 hrs, larvae L3    139 Ethanol 5% 3 hrs, larvae L3    176 Ethanol 10% 3 hrs, larvae L3    209 Caffeine 1.5 mg/ml 4 hrs, larvae L3    112 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    89 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    168 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    136 Rotenone 8 μg 12 hrs, larvae L3    263 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    18 heat shock, 4-day adult  (209) Cadmium 50 mM 6 hrs, larvae L3  (181) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (174) Cadmium 100 mM 48 hrs, 4-day adult  (81) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (142) Zinc 5 mM 12 hrs, larvae L3  (30) Zinc 4.5 mM 48 hrs, 4-day adult  (128) Ethanol 2.5% 3 hrs, larvae L3  (139) Ethanol 5% 3 hrs, larvae L3  (176) Ethanol 10% 3 hrs, larvae L3  (209) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (112) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (89) Caffeine 25 mg/ml 48 hrs, 4-day adult  (53) Paraquat 5 mM 48 hrs, 4-day adult  (168) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  (136) Rotenone 8 μg 12 hrs, larvae L3  (263) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    18 heat shock, 4-day adult  (209) Cadmium 50 mM 6 hrs, larvae L3  (181) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (174) Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult  (142) Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult  (128) Ethanol 2.5% 3 hrs, larvae L3  (139) Ethanol 5% 3 hrs, larvae L3  (176) Ethanol 10% 3 hrs, larvae L3  (209) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (112) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    89 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult  (168) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  (136) Rotenone 8 μg 12 hrs, larvae L3  (263) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    18 heat shock, 4-day adult    209 Cadmium 50 mM 6 hrs, larvae L3    181 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    174 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    128 Ethanol 2.5% 3 hrs, larvae L3    139 Ethanol 5% 3 hrs, larvae L3    176 Ethanol 10% 3 hrs, larvae L3    209 Caffeine 1.5 mg/ml 4 hrs, larvae L3    112 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    89 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    168 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    136 Rotenone 8 μg 12 hrs, larvae L3    263 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    18 heat shock, 4-day adult    209 Cadmium 50 mM 6 hrs, larvae L3    181 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    174 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    128 Ethanol 2.5% 3 hrs, larvae L3    139 Ethanol 5% 3 hrs, larvae L3    176 Ethanol 10% 3 hrs, larvae L3    209 Caffeine 1.5 mg/ml 4 hrs, larvae L3    112 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    89 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    168 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    136 Rotenone 8 μg 12 hrs, larvae L3    263 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    18 heat shock, 4-day adult  (209) Cadmium 50 mM 6 hrs, larvae L3  (181) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (174) Cadmium 100 mM 48 hrs, 4-day adult  (81) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (142) Zinc 5 mM 12 hrs, larvae L3  30 Zinc 4.5 mM 48 hrs, 4-day adult  (128) Ethanol 2.5% 3 hrs, larvae L3  (139) Ethanol 5% 3 hrs, larvae L3  (176) Ethanol 10% 3 hrs, larvae L3  (209) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (112) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (89) Caffeine 25 mg/ml 48 hrs, 4-day adult  (53) Paraquat 5 mM 48 hrs, 4-day adult  (168) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  (136) Rotenone 8 μg 12 hrs, larvae L3  (263) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    18 heat shock, 4-day adult  (209) Cadmium 50 mM 6 hrs, larvae L3  (181) Cadmium 50 mM 12 hrs, larvae L3  132 Cadmium 50 mM 48 hrs, 4-day adult  (174) Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult  142 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult  128 Ethanol 2.5% 3 hrs, larvae L3  139 Ethanol 5% 3 hrs, larvae L3  (176) Ethanol 10% 3 hrs, larvae L3  (209) Caffeine 1.5 mg/ml 4 hrs, larvae L3  112 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    89 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult  (168) Paraquat 10 mM 48 hrs, 4-day adult  (189) Rotenone 2 μg 12 hrs, larvae L3  136 Rotenone 8 μg 12 hrs, larvae L3  (263) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    18 heat shock, 4-day adult    209 Cadmium 50 mM 6 hrs, larvae L3    181 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    174 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    30 Zinc 4.5 mM 48 hrs, 4-day adult    128 Ethanol 2.5% 3 hrs, larvae L3    139 Ethanol 5% 3 hrs, larvae L3    176 Ethanol 10% 3 hrs, larvae L3    209 Caffeine 1.5 mg/ml 4 hrs, larvae L3    112 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    89 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    168 Paraquat 10 mM 48 hrs, 4-day adult    189 Rotenone 2 μg 12 hrs, larvae L3    136 Rotenone 8 μg 12 hrs, larvae L3    263 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011227 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8764-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | recessive | somatic clone ox107-2 lethal | recessive ox107-2 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 oxGD13728 partially lethal - majority die | recessive ox1 viable oxEY03539 Sterility Allele fertile oxEY03539 male sterile ox1 male sterile (with Df(2R)12-1) ox1 male sterile (with Df(2R)38-1) ox1 male sterile (with Df(2R)44-2) ox1 male sterile (with Df(2R)68-1) ox1 male sterile (with Df(2R)86-1) ox1 male sterile (with Df(2R)107-2) ox1 male sterile (with Df(2R)157-1) ox1 male sterile | recessive ox1 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 oxGD13728 wild-type oxhs.PF Phenotype manifest in Allele oocyte | germline clone ox107-2 trichogen cell, with Scer\GAL4pnr-MD237 oxGD13728
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of ox Class Mutagen Stocks Known lesion ox1 P-element activity 2 Yes oxc05813 piggyBac transposase 1 -- oxEY03539 P-element activity 1 -- ox107-2 Delta2-3 0 Yes ox12-1 Delta2-3 0 Yes ox157-1 Delta2-3 0 Yes oxrev Delta2-3 0 Yes oxunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ox Class Mutagen Stocks Known lesion oxGD13728 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes oxGD15491 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes oxhs.PF in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)12-1 (Frolov et al., 2000) Df(2R)38-1 (Frolov et al., 2000) Df(2R)44-2 (Frolov et al., 2000) Df(2R)68-1 (Frolov et al., 2000) Df(2R)86-1 (Frolov et al., 2000) Df(2R)107-2 (Frolov et al., 2000) Df(2R)157-1 (Frolov et al., 2000) Df(2R)vg135 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)vg-C (Castrillon et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-ox.F} NA UAS construct P{GD13728} NA P{GD15491} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}ox1 No insertion of mobile activating element P{EPgy2}oxEY03539 NA miscellaneous insertions PBac{PB}oxc05813 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
spermatid development inferred from mutant phenotype (Castrillon et al., 1993)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ubiquinol-cytochrome-c reductase activity inferred from sequence or structural similarity with UniProtKB:Q9UDW1 (Sardiello et al., 2003.6.11) non-traceable author statement (Benevolenskaya, 1997.8.7, Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
mitochondrial electron transport, ubiquinol to cytochrome c inferred from sequence or structural similarity with UniProtKB:Q9UDW1 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial respiratory chain complex III inferred from sequence or structural similarity with UniProtKB:Q9UDW1 (Sardiello et al., 2003.6.11) non-traceable author statement (Benevolenskaya, 1997.8.7, Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ox - ATPsyn-γ experimental knowledge based (Guruharsha et al., 2011) ox - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Arf79F experimental knowledge based (Guruharsha et al., 2011) ox - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG11190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG11306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG11876 experimental knowledge based (Guruharsha et al., 2011) ox - CG11911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG12057 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG12262 experimental knowledge based (Guruharsha et al., 2011) ox - CG12818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG13295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG1416 experimental knowledge based (Guruharsha et al., 2011) ox - CG1444 experimental knowledge based (Guruharsha et al., 2011) ox - CG15484 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG17834 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG2064 experimental knowledge based (Guruharsha et al., 2011) ox - CG2789 experimental knowledge based (Guruharsha et al., 2011) ox - CG30338 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG31199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG31675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG33303 experimental knowledge based (Guruharsha et al., 2011) ox - CG3876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG4169 experimental knowledge based (Guruharsha et al., 2011) ox - CG5660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG6073 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG6453 experimental knowledge based (Guruharsha et al., 2011) ox - CG7053 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG7655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG7675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG8735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - CG8939 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Ca-P60A experimental knowledge based (Guruharsha et al., 2011) ox - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Droj2 experimental knowledge based (Guruharsha et al., 2011) ox - Dsor1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Flo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Gαo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - ImpL3 experimental knowledge based (Guruharsha et al., 2011) ox - Jon44E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - KdelR experimental knowledge based (Guruharsha et al., 2011) ox - Kr-h2 experimental knowledge based (Guruharsha et al., 2011) ox - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Mec2 experimental knowledge based (Guruharsha et al., 2011) ox - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Pdk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Rab5 experimental knowledge based (Guruharsha et al., 2011) ox - Sln anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - Tapδ experimental knowledge based (Guruharsha et al., 2011) ox - ldbr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - ninaE anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - porin experimental knowledge based (Guruharsha et al., 2011) ox - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - slbo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - tyn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ox - wal experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ox allele Gene References ox1 w (Frolov et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69656 DroID - A comprehensive database of gene and protein interactions. • FBgn0011227 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45401
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G4HBB Dipteran inclusive ortholog search EOG6R50CK Insect inclusive ortholog search EOG69P8WT Arthropod inclusive ortholog search EOG6PK0S7 Metazoa inclusive ortholog search EOG6C2W6Q
Orthologs in Drosophila Species (EOG6G4HBB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ox     Drosophila simulans   Dsim\GD25813 Y   Drosophila sechellia   Dsec\GM20336 Y   Drosophila erecta   Dere\GG22552 Y   Drosophila yakuba   Dyak\ox Y   Drosophila ananassae   Dana\GF13094 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21302 Y   Drosophila persimilis   Dper\GL17726 Y   Drosophila willistoni   Dwil\GK21685 Y   Drosophila virilis   Dvir\GJ15078 Y   Drosophila mojavensis   Dmoj\GI19909 Y   Drosophila grimshawi   Dgri\GH19952 Y
Orthologs in non-Drosophila Dipterans (EOG6R50CK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000182   Anopheles gambiae Malaria mosquito  Agam\AGAP004710   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000728
Orthologs in non-Dipteran Insects (EOG69P8WT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC100578782   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011942   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17449   Atta cephalotes Leafcutter ant  Acep\ACEP22161   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16894   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14637   Linepithema humile Argentine ant  Lhum\LH19497   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20047   Acyrthosiphon pisum Pea aphid  Apim\ACYPI063291   Acyrthosiphon pisum Pea aphid  Apim\ACYPI40537   Pediculus humanus Human body louse  Phum\PHUM392790   Tribolium castaneum Red flour beetle  Tcas\Ucrc
Orthologs in non-Insect Arthropods (EOG6PK0S7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\matK   Ixodes scapularis Deer tick  Isca\ISCW008376
Orthologs in non-Arthropod Metazoa (EOG6C2W6Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Xenopus tropicalis Western clawed frog  Xtro\uqcr10   Gallus gallus Domestic chicken  Ggal\LOC770937   Mus musculus House mouse  Mmus\Uqcr10   Rattus norvegicus Norway rat  Rnor\LOC100361126   Homo sapiens Human  Hsap\UQCR10
Human Orthologs (1)
Gene OMIM HGNC Hsap\UQCR10
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25813 Drosophila sechellia Dsec\GM20336 Drosophila erecta Dere\GG22552 Drosophila yakuba Dyak\ox Drosophila ananassae Dana\GF13094 Drosophila pseudoobscura pseudoobscura Dpse\GA21302 Drosophila persimilis Dper\GL17726 Drosophila willistoni Dwil\GK21685 Drosophila virilis Dvir\GJ15078 Drosophila mojavensis Dmoj\GI19909 Drosophila grimshawi Dgri\GH19952
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	19680 y1 w67c23; P{EPgy2}oxEY03539 11754 cn1 P{PZ}ox1 Dgkεox-1/CyO; ry506
Harvard	- PBac{PB}oxc05813
Kyoto	101942 cn1 P{PZ}ox1 / CyO ; ry506
VDRC	v35828 w1118; P{GD13728}v35828 v35829 w1118; P{GD13728}v35829
Genomic Clones ( 1 )
	BACR33L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM22210 RH44662
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22548
Other clones	bs45h09 bs62c03 CK01.141A.A8 Dmel_dig_016194_0683_1357 Dmel_dig_016311_0644_1767 Dmel_neb_008184_0892_2631 Dmel_neb_011128_0681_2588 Dmel_neb_011916_0130_1700 Dmel_neb_013094_0680_3756 EK116936 IP14308
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011227 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45401
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ox BcDNA:RH44662 (FlyBase, 1996-) Source for merge of: ox Qcr10 (Frolov et al., 2000)
Additional comments	"ox" may correspond to "Qcr9", "Dgkε" or "Nacα": the "ox1" mutation affects the RNA levels of "Qcr9", "Dgkε" and "Nacα". (Birchler, 1999.5.10) Source for merge of ox BcDNA:RH44662 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Postmeiotic differentiation defect. (Castrillon et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057637 RefSeq (Proteins) • NP_476985 DDBJ / EMBL / GenBank • AAD28637 AAF58459 AAL49349 AC007453 AC091499 AF017783 AI063477 AI403164 AQ026399 AY071727 BI615124 CL610142 CZ470275 Entrez Gene - A searchable database of RefSeq genes. • 45401 UniProtKB/Swiss-Prot • Q9XY35 UniProtKB/TrEMBL • Q8SY81
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b-c1 complex subunit 9 (IPR008027) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08764
Linkouts
	BioGRID - A database of protein and genetic interactions • 69656 DroID - A comprehensive database of gene and protein interactions. • FBgn0011227 DRSC - Results from RNAi screens. • FBgn0011227 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011227 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8764-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011227 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45401 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45401 modMine - Data generated by the modENCODE project. • FBgn0011227
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	BcDNA:RH44662   CG8764 (Porcelli et al., 2007, Cammarato et al., 2011) ms(2)00815   ox (Dorus et al., 2006, Tripoli et al., 2005, Dorus et al., 2006, Wasbrough et al., 2010, Malone et al., 2012) QCR9 (Frolov et al., 2000) Qcr9 (Birchler, 1999.5.10, ) Qcr10   unnamed (Benevolenskaya, 1997.8.7)
Name Synonym	oxen (Wasbrough et al., 2010, Cammarato et al., 2011) Ubiquinol-cytochrome c oxidoreductase 7.2 kDa (Porcelli et al., 2007) Ubiquinol-cytochrome C reductase (Lemos et al., 2010) Ubiquinol-cytochrome c reductase 7.2 kDa protein (Tripoli et al., 2005)
Secondary FlyBase IDs
	FBgn0024946 FBgn0026780 FBgn0047014
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...