Ken & Barbie, ok, okina
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ken using the Feature Mapper tool.
ken expression is enriched in border follicle cells relative to other cells in the egg chamber.
Northern analysis indicates that expression of ken is higher during embryonic and pupal stages than in larval stages. Expression of ken is higher in adult females than in males. ken transcript is expressed ubiquitously in both male and female genital discs and eye-antennal discs. In the embryo ken transcript is detected in stage 5 blastoderm embryos as 2 stripes at 64% and 17% egg length. Expression is stronger with the anterior expression just posterior to the cephalic furrow and posterior expression confined to the hindgut primordium. Anterior expression disappears by stage 9 and then reappears in the foregut at stage 15. Posterior expression is confined to the hindgut and anal pad.
ken transcripts are first detected in early stage 5 embryos in two circumferential rings around the embryo at 17% and 64% egg length. At the end of stage 5, they co-localize with the first and seventh ftz stripes. The anterior stripe fades while the staining in the posterior domain persists until the end of embyrogenesis in the posterior spiracles. Expression is also observed at stage 16 in the foregut, the proventriculus, the dorsal pouch, the hindgut, and the anal pads.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ken in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Mutants show malformation of adult terminalia.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Mutant homozygous males prematurely terminate copulation.
Sperm transfer defect.
Locus originally described and named by C. Berg.