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General Information
Symbol
Dmel\Sema1a
Species
D. melanogaster
Name
Semaphorin 1a
Annotation Symbol
CG18405
Feature Type
FlyBase ID
FBgn0011259
Gene Model Status
Stock Availability
Gene Snapshot
Semaphorin 1a (Sema1a) encodes a transmembrane protein belonging to the semaphorin protein family. It is a repulsive axon guidance cue, signaling through direct interactions with the receptor encoded by PlexA, and also functions as a receptor to regulate dendrite targeting and axon guidance. Secreted semaphorins encoded by Sema2a and Sema2b can act as the product of Sema1a ligands. [Date last reviewed: 2019-03-14]
Also Known As
Sema-1a, Sema 1a, D-SemaI, semaphorin, Fasciclin-IV
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:8,542,147..8,672,041 [+]
Recombination map
2-33
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the semaphorin family. (Q24322)
Molecular Function (GO)
[Detailed GO annotations]
Summaries
Gene Group (FlyBase)
SEMAPHORINS -
The Semaphorins are a family of membrane and secreted short-range signaling proteins, originally characterized for their role in axon guidance. The major signal transducing receptors for the semaphorins are the plexins. (Adapted from FBrf0233112, FBrf0137217 and PMID:23253452).
Protein Function (UniProtKB)
Involved in growth cone guidance through its role in axonal repulsion.
(UniProt, Q24322)
Summary (Interactive Fly)
axon guidance transmembrane protein - motor axons requiring Sema-1a for choice-point defasciculation - Sema-1a reverse signaling promotes midline crossing in response to secreted semaphorins - prevents Drosophila olfactory projection neuron dendrites from mis-targeting into select antennal lobe regions
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\Sema1a or the JBrowse view of Dmel\Sema1a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.44
Alternative translation stop created by use of multiphasic reading frames within coding region.
Stop-codon suppression (UGA) postulated; FBrf0216884.
gene_with_stop_codon_read_through ; SO:0000697
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0079691
5661
899
FBtr0303877
9706
905
FBtr0303878
9624
905
FBtr0303879
7980
826
FBtr0329930
5679
1131
FBtr0329931
9751
820
FBtr0329932
7826
817
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0079302
101.1
899
7.41
FBpp0292880
101.6
905
7.41
FBpp0292881
101.6
905
7.41
FBpp0292882
93.0
826
6.70
FBpp0302962
126.3
1131
7.25
FBpp0302963
92.5
820
6.70
FBpp0302964
92.1
817
6.70
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

905 aa isoforms: Sema1a-PD, Sema1a-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sema1a using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (19 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:PlexA; FB:FBgn0025741
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
traceable author statement
Biological Process (13 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002593045
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000744245
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000744245
(assigned by GO_Central )
inferred from sequence or structural similarity
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Sema-1a expression is first detected at embryonic stage 10 and reaches a peak at stage 16. It is expressed in most CNS neurons. It is weakly expressed in the PNS, mainly in lateral sensory clusters.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Sema1a is widely expressed in the thoracic neuromere but expression decreases towards the midline where it is at its lowest.
Sema-1a protein is expressed in the lateral antennal lobe. The level of expression of Sema-1a is opposite to the one of Sema2b : if the expression level of Sema-1a is high, the one of Sema2a is low, and vice-versa.
Sema1a is first detected in sensory neuropil at embryonic stage 13 and persists until the end of embryogenesis. The highest levels are in the lateral and intermediate portions of layers 1 and 3, with lower levels in layer 2 and none in layer 4 (layers 1-4 defining four regions in the dorsal/ventral axis with 1 being the dorsal-most layer).
Sema-1a protein is expressed in the cell bodies and axons of the photoreceptors in the lamina, medulla and optic stalk. It also labels axons of other cells in the medulla.
In the late third instar larva, Sema-1a protein is diffusely distributed in brain, preferentially in the optic lobes. Sema-1a protein is also expressed in the thoracic segments of the ventral nerve cord, and at the midline of the thoracic and abdominal segments. At prepupal stages, Sema-1a protein is localized to the central brain, optic lobes, subesophageal neuromere, connectives, and the thoracic neuromeres. At mid-pupal stages when the giant fiber--tergotrochanteral muscle motor neuron synapses are forming, the Sema-1a expression pattern becomes more refined. At these stages, Sema-1a protein is localized to several layers of the medulla, the alpha and alpha' lobes of the mushroom body, and the outer neuropil of the neuromeres. Expression fades in later pharate adult stages.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sema1a in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sema1a
Transgenic constructs containing regulatory region of Sema1a
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdominal ventral longitudinal muscle & synapse
axon & alpha'-lobe | somatic clone
axon & antennal glomerulus DA1 | somatic clone
axon & antennal glomerulus DC3 | somatic clone
axon & antennal glomerulus DL1 | somatic clone | cell autonomous
axon & antennal glomerulus VM2 | somatic clone
axon & beta'-lobe | somatic clone
axon & eye photoreceptor cell
axon & eye photoreceptor cell, with Scer\GAL4GMR.PF
axon & eye photoreceptor cell (with Df(2L)N22-5)
axon & eye photoreceptor cell | somatic clone | cell autonomous
axon & lamina, with Scer\GAL4GMR.PF
axon & lamina (with Df(2L)N22-5)
axon & lamina | somatic clone | somatic clone | cell autonomous
axon & medulla, with Scer\GAL4GMR.PF
dendrite & antennal glomerulus | somatic clone, with Scer\GAL4GH146
dendrite & antennal glomerulus DA1 | somatic clone
dendrite & antennal glomerulus DC3 | somatic clone
dendrite & antennal glomerulus DL1 | somatic clone
eye photoreceptor cell & lamina
eye photoreceptor cell & lamina, with Scer\GAL4GMR.PF
eye photoreceptor cell & lamina (with Df(2L)N22-5)
eye photoreceptor cell & lamina | somatic clone | cell autonomous
eye photoreceptor cell & medulla, with Scer\GAL4GMR.PF
nerve terminal & lamina plexus, with Scer\GAL4GMR.PF
photoreceptor cell R1 & axon
photoreceptor cell R1 & lamina
photoreceptor cell R2 & axon
photoreceptor cell R2 & lamina
photoreceptor cell R3 & axon
photoreceptor cell R3 & lamina
photoreceptor cell R4 & axon
photoreceptor cell R4 & lamina
photoreceptor cell R5 & axon
photoreceptor cell R5 & lamina
photoreceptor cell R6 & axon
photoreceptor cell R7 & lamina
RP3 neuron & synapse
RP5 neuron & synapse
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
No
8 of 15
Yes
No
7 of 15
No
No
7 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
Yes
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
No
Yes
8 of 15
Yes
No
7 of 15
No
No
7 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
7 of 13
No
Yes
6 of 13
No
No
6 of 13
No
No
5 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
6 of 12
Yes
Yes
4 of 12
No
No
4 of 12
No
No
3 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (36)
8 of 15
Yes
No
8 of 15
Yes
No
7 of 15
No
No
5 of 15
No
No
4 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
10 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901KP )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501HE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02X1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03JM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0QST )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
4 of 10
4 of 10
4 of 10
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-33
    Cytogenetic map
    Sequence location
    2L:8,542,147..8,672,041 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    29E1-29E3
    Limits computationally determined from genome sequence between P{PZ}lmg03424 and P{lacW}Sema-1ak13702
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    29E1-29E2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (40)
    Genomic Clones (66)
    cDNA Clones (72)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Sema1a Sema-1a
    Source for database merge of
    Source for merge of: Sema-1a BcDNA:RE36155
    Additional comments
    Source for merge of Sema-1a BcDNA:RE36155 was a shared cDNA ( date:030728 ).
    Other Comments
    Sema-1a forward signaling is largely responsible for Sema-1a-mediated central nervous system axon guidance, whereas both forward and reverse signaling are required for Sema-1a-mediated peripheral nervous system motor axon pathfinding.
    Sema-1a-mediated motor axon defasciculation is promoted by pbl and inhibited by RhoGAPp190. The opposing pbl and RhoGAPp190 functions mediate Sema-1a reverse signaling through the regulation of Rho1 activity.
    Sema-1a acts non-autonomously to control olfactory receptor neuron axon-axon interactions. Sema-1a protein on antennal olfactory receptor neurons is required for correct targeting of maxillary palp olfactory receptor neuron axons within the antennal lobe.
    nvy and Sema-1a function in the same signaling pathway but have opposing effects. nvy acts downstream of Sema-1a to regulate repulsive axon guidance.
    otk appears to ne an important component for repulsive signalling in response to Semaphorin ligands in axon guidance.
    Sema-1a mediates axonal guidance defasciculation events by acting as an axonally localised repellent.
    Sema-1a is required for the correct guidance of motor axons and for the formation of central nervous system pathways.
    Sema-1a encodes a transmembrane protein whose distribution suggests a function in axon guidance.
    Identified on basis of similarity to grasshopper semaphorin.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 70 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (39)
    Reported As
    Symbol Synonym
    BcDNA:RE36155
    D-Sema I
    D-Sema-I
    Fas-IV
    d-sema I
    l(2)k13702
    Secondary FlyBase IDs
    • FBgn0021877
    • FBgn0063028
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (199)