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Gene Dmel\Rya-r44F

General Information
Symbol	Dmel\Rya-r44F	Species	D. melanogaster
Name	Ryanodine receptor 44F	Annotation symbol	CG10844
Feature type	protein_coding_gene	FlyBase ID	FBgn0011286
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	RyR, l(2)k04913, dry, DRR
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44F1-44F2	Sequence location	2R:4,747,869..4,775,602 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ryanodine receptor 44F is referred to in FlyBase by the symbol Dmel\Rya-r44F (CG10844, FBgn0011286). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ryanodine-sensitive calcium-release channel activity. There is experimental evidence that it is involved in the biological process: muscle contraction; regulation of hemocyte proliferation. 16 alleles are reported. The phenotypes of these alleles are annotated with: larva; larval head; embryonic/larval dorsal vessel; presumptive embryonic/larval muscle system; embryonic/larval visceral muscle; embryonic/larval muscle system. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: B30.2/SPRY domain; Concanavalin A-like lectin/glucanases superfamily; EF-hand-like domain; Inositol 1,4,5-trisphosphate/ryanodine receptor; Intracellular calcium-release channel; Ion transport domain; MIR motif; RyR/IP3R Homology associated domain; Ryanodine Receptor TM 4-6; Ryanodine receptor; Ryanodine receptor Ryr; Ryanodine receptor-related; SPla/RYanodine receptor SPRY; SPla/RYanodine receptor subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633452_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Rya-r44F. Gene sequence location is 2R:4747869..4775602.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Rya-r44F[MI08146]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44F1-44F2   Limits computationally determined from genome sequence between P{PZ}l(2)44DEa05847 and P{lacW}Rya-r44Fk04913
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44F-44F     (Takeshima, 1994) 44F1-44F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 44F1-44F2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 44F-44F   (determined by in situ hybridisation)   (Takeshima et al., 1994)   Stated (in error) to map to 76C--D (by in situ hybridisation).   (Hasan and Rosbash, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rya-r44F for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rya-r44F-RA FBtr0088640  NM_057643   15812   5127 Rya-r44F-RB FBtr0088638  NM_057644   15770   5113 Rya-r44F-RC FBtr0088637  NM_057645   15847   5127 Rya-r44F-RD FBtr0088639  NM_057646   15770   5113 Rya-r44F-RE FBtr0304568  NM_001259278   16003   5117 Rya-r44F-RF FBtr0304569  NM_001259279   15788   5119 Rya-r44F-RG FBtr0304570  NM_001259280   16056   5123 Rya-r44F-RH FBtr0304571  NM_001259281   16042   5130 Rya-r44F-RI FBtr0304572  NM_001259282   15871   5134 Rya-r44F-RJ FBtr0308083  NM_001259277   15811   5115
Additional Transcript Data & Comments
Reported size (kB)	16 (northern blot) (Takeshima et al., 1994) 15 (northern blot) (Hasan and Rosbash, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rya-r44F-PA   FBpp0087721   581.0   5127   5.32     NP_476991   AAF59036 Rya-r44F-PB   FBpp0087719   579.7   5113   5.32     NP_476992   AAM71082 Rya-r44F-PC   FBpp0087718   580.8   5127   5.29     NP_476993   AAM71083 Rya-r44F-PD   FBpp0087720   579.5   5113   5.29     NP_476994   AAM71084 Rya-r44F-PE   FBpp0293110   580.0   5117   5.29     NP_001246207   AFH07962 Rya-r44F-PF   FBpp0293111   580.3   5119   5.32     NP_001246208   AFH07963 Rya-r44F-PG   FBpp0293112   580.5   5123   5.33     NP_001246209   AFH07964 Rya-r44F-PH   FBpp0293113   581.3   5130   5.37     NP_001246210   AFH07965 Rya-r44F-PI   FBpp0293114   581.4   5134   5.32     NP_001246211   AFH07966 Rya-r44F-PJ   FBpp0300426   579.9   5115   5.40     NP_001246206   AFH07961
Additional Polypeptide Data & Comments
Reported size (kDa)	5126, 5112 (aa) (Takeshima et al., 1994) 509 (aa) (Hasan and Rosbash, 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SPla/RYanodine receptor subgroup (IPR018355) Ryanodine receptor-related (IPR015925) Intracellular calcium-release channel (IPR000699) Ryanodine receptor Ryr (IPR003032) SPla/RYanodine receptor SPRY (IPR003877) Ion transport domain (IPR005821) Ryanodine Receptor TM 4-6 (IPR009460) EF-hand-like domain (IPR011992) Ryanodine receptor (IPR013333) RyR/IP3R Homology associated domain (IPR013662) B30.2/SPRY domain (IPR001870) Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821) MIR motif (IPR016093) Concanavalin A-like lectin/glucanases superfamily (IPR008985)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140702   AA699060   AA699121   AE013599 AAF59036   AE013599 AAM71082   AE013599 AAM71083   AE013599 AAM71084   AC007471   AE013599 AFH07961   AE013599 AFH07962   AE013599 AFH07963   AE013599 AFH07964   AE013599 AFH07965   AE013599 AFH07966   AI113584   AI404189   AI405910   AK257639   AK257821   AK259943   AK260559   AK265824   AK281806   AK282194   AQ025750   AX093878   BF488910   BG632523   BI369375   BI369384   BI565262   BI566685   BI568738   BI574625   BI574941   BI581258   BI581397   BI583719   BI584956   BI604398   BI606989   BI608972   BI615897   BI621165   BI622213   BI622511   BI628560   BI630045   BI631009   BI631115   BI631867   BI634576   BT120191   BT128703   CO177752   CO185322   CO187265   CO264276   CO279230   CO301647   CO307176   CO309773   CZ473503   D17389 BAA04212   D17389 BAA41469   D17389 BAA41470   D17389 BAA41471   EC062787   EC068418   EC084476   EC203489   EC236475   EC240909   EC244595   ES692301   EW713014   FL502408   FL502578   FL502678   GH291314   GH291394   GH941618   GH944182   GH944305   GH945156   GH945584   GH945972   GH946694   GH946987   GH948466   GH948485   GH948848   GH948934   GH949485   GH949680   GH949935   GH950144   GH950938   GH952316   GH955021   GH959135   GH959932   GH963157   GH966746   GH967075   GH967247   GH970341   GH971994   GH977920   GH978227   GH979204   GH979672   GH980052   GH984718   GH985017   HM449918   Z18536 CAA79221   Z50297   Z71006
UniProtKB/Swiss-Prot	Q24498
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 17   somatic muscle   (Hasan and Rosbash, 1992) skeletal muscle of head   (Hasan and Rosbash, 1992) adult stage   subesophageal ganglion   (Hasan and Rosbash, 1992) mesothoracic extracoxal depressor muscle 66   (Hasan and Rosbash, 1992) adult brain   (Hasan and Rosbash, 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Sullivan et al., 2000) embryonic/larval muscle system   (Hasan and Rosbash, 1992) embryonic stage 9 -- 17   mesoderm   (Sullivan et al., 2000, Hasan and Rosbash, 1992) embryonic stage 13 -- 16   embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic stage 14   embryonic/larval hypodermal muscle   (Sullivan et al., 2000) embryonic/larval visceral muscle   (Sullivan et al., 2000) adult stage   proboscis muscle   (Hasan and Rosbash, 1992) skeletal muscle of head   (Hasan and Rosbash, 1992) skeletal muscle of leg   (Hasan and Rosbash, 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 15     (Takeshima et al., 1994) Comment:reference states 6-12 hr AEL second instar larval stage     (Takeshima et al., 1994) third instar larval stage     (Takeshima et al., 1994)
Additional Descriptive Data
	Rya-r44F transcript is first detected in the mesoderm at stage 9, and levels increase starting at stage 13. Highest levels are seen in hypodermal and visceral muscles. Expression is detected at lower levels in other tissues, including the CNS. (Sullivan et al., 2000) Rya-r44F transcripts are detected in RNA from embryos, larvae, and adults, but not in pupal RNA. They are more abundant in RNA from body than head. In embryos, transcripts are first detected in the mesoderm in stage 9. Subsequently, transcripts are found in somatic and cephalic muscle precursors, and later, in all of the somatic muscles and a subset of the cephalic muscles. In adults, Rya-r44F transcripts are expressed maximally in tubular muscles of the thorax, namely the tergotrochanteral muscle and the leg muscles. Expression is also observed in the cortex of the ventral ganglion and brain and in muscles of the head and proboscis. (Hasan and Rosbash, 1992) Expression is high in 6-12 hr embryos, low in second and third instar larvae, and absent from adults and pupae. (Takeshima et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut    10.6 Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea    15.425 Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules    10.5 Adult Fat Body    13 Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    71.4   NA  Eye    59.525   NA  Brain    188.6   39.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    221.8   NA  Crop    195.7   no informative data  Midgut    18.6   79  Hindgut    141.8   2.6  Malpighian Tubules    no informative data   8.5  Fat Body    no informative data   4  Salivary Gland    8.9   NA  Heart    228.675   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    15.7   NA  InseminatedFemale Spermatheca    25.3   NA  Ovary    5.5   NA  Testis    20.7   NA  Male Accessory Gland    63.9   411.475  Carcass    324.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult  (28) carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult  28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    10 head, virgin 1-day female    13 head, virgin 4-day female    9 head, virgin 20-day female    7 head, mated 1-day female    11 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    16 head, mated 4-day male    11 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    28 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP    74 pupae 4d postWPP    43 adult male 01day    42 adult male 05day    32 adult male 30day    25 adult female 01day    26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr  (31) embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old  (32) larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP  (74) pupae 4d postWPP  (43) adult male 01day  (42) adult male 05day  (32) adult male 30day    25 adult female 01day  26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP    74 pupae 4d postWPP    43 adult male 01day    42 adult male 05day    32 adult male 30day    25 adult female 01day    26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP    74 pupae 4d postWPP    43 adult male 01day    42 adult male 05day    32 adult male 30day    25 adult female 01day    26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP    74 pupae 4d postWPP    43 adult male 01day    42 adult male 05day    32 adult male 30day    25 adult female 01day    26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr  31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old  32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP  (74) pupae 4d postWPP  (43) adult male 01day  (42) adult male 05day  32 adult male 30day    25 adult female 01day  26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP    74 pupae 4d postWPP    43 adult male 01day    42 adult male 05day    32 adult male 30day    25 adult female 01day    26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    11 embryo 12-14hr    20 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    16 larva L1    19 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    3 white prepupae 24hr    7 pupae 2d postWPP    20 pupae 3d postWPP    74 pupae 4d postWPP    43 adult male 01day    42 adult male 05day    32 adult male 30day    25 adult female 01day    26 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • PC00136 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011286 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10844-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rya-r44F Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)Np3) Rya-r44F16 lethal | recessive Rya-r44Fk00424b Rya-r44Fk04913 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW Rya-r44FJF03381 Other Phenotypes Allele feeding behavior defective Rya-r44F16 locomotor behavior defective | larval stage Rya-r44F16 Phenotype manifest in Allele embryonic/larval dorsal vessel Rya-r44F16 embryonic/larval muscle system Rya-r44F16 embryonic/larval muscle system (with Df(2R)Np3) Rya-r44F16 embryonic/larval visceral muscle Rya-r44F16 Rya-r44Fk04913 larva Rya-r44F16 larval head Rya-r44F16 presumptive embryonic/larval muscle system Rya-r44FdsRNA.cSa
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Rya-r44F Class Mutagen Stocks Known lesion Rya-r44Fk04913 P-element activity 2 Yes Rya-r44F16 Delta2-3 1 Yes Rya-r44Fd03686 P-element activity 1 -- Rya-r44FEY12439 1 -- Rya-r44FMI06312 1 -- Rya-r44FNP3006 1 -- Rya-r44Fk00424b P-element activity 0 -- Rya-r44FMI08146 0 -- Rya-r44FSH0622 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rya-r44F Class Mutagen Stocks Known lesion Rya-r44FHM05130 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FJF01100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FJF01101 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FJF03381 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FdsRNA.cSa in vitro construct - RNAi 0 Yes Rya-r44FGD1882 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rya-r44FKK101716 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rya-r44FNIG.10844R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC268 (Christensen et al., 2008.12.28) Df(2R)BSC269 (Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22) Df(2R)Np3 (Abmayr, 1998.5.1, Spradling et al., 1999, Prokopenko et al., 2000, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)44CE (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)G75 (BDGP Project Members, 1994-1999) Df(2R)H3C1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np1 (Abmayr, 1998.5.1, Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np5 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)P14TE (Abmayr, 1998.5.1)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1882} NA P{KK101716} NA P{NIG.10844R} NA P{TRiP.HM05130} NA P{TRiP.JF01100} NA P{TRiP.JF01101} NA P{TRiP.JF03381} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH1495SH1495 No P{lacW}Rya-r44Fk00424b No P{lacW}Rya-r44Fk04913 No P{lacW}Rya-r44FSH0622 No insertion of mobile activating element P{EPgy2}Rya-r44FEY12439 NA P{XP}Rya-r44Fd03686 NA insertion of enhancer trap binary system P{GawB}Rya-r44FNP3006 No miscellaneous insertions Mi{MIC}Rya-r44FMI06312 NA Mi{MIC}Rya-r44FMI08146 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
muscle contraction inferred from mutant phenotype (assigned by UniProtKB) (Sullivan et al., 2000) regulation of hemocyte proliferation inferred from mutant phenotype (Sinenko et al., 2010)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR011992 (FlyBase Curators et al., 2004-) ryanodine-sensitive calcium-release channel activity inferred from sequence or structural similarity with EMBL:U50465 (FlyBase, 1992-) non-traceable author statement (Hasan, 1992.11.20, Takeshima, 1994) traceable author statement (assigned by UniProtKB) (Takeshima et al., 1994)
Biological Process
CV term Evidence References
calcium ion transmembrane transport inferred from electronic annotation with InterPro:IPR000699 (FlyBase Curators et al., 2004-) calcium ion transport traceable author statement (assigned by UniProtKB) (Takeshima et al., 1994) cellular calcium ion homeostasis inferred from electronic annotation with InterPro:IPR009460 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane non-traceable author statement (Takeshima, 1994) integral to membrane inferred from electronic annotation with InterPro:IPR009460 (FlyBase Curators et al., 2004-) non-traceable author statement (assigned by UniProtKB) (Takeshima et al., 1994)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Rya-r44F - CG14315 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Rya-r44F - l(2)01289 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rya-r44F allele Gene References Rya-r44F16 Cam (Wang et al., 2003) Rya-r44Fk04913 peb (Wilk et al., 2004) Pkd2 (Gao et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71972 DroID - A comprehensive database of gene and protein interactions. • FBgn0011286 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49090
Orthologs
OrthoDB Orthologs (87) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69S6RN Dipteran inclusive ortholog search EOG6G1MQ8 Insect inclusive ortholog search EOG6RV1M4 Arthropod inclusive ortholog search EOG6RN8Q7 Metazoa inclusive ortholog search EOG67X1FB
Orthologs in Drosophila Species (EOG69S6RN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rya-r44F     Drosophila simulans   Dsim\GD10606 Y   Drosophila sechellia   Dsec\GM21070 Y   Drosophila erecta   Dere\GG23389 Y   Drosophila yakuba   Dyak\GE19231 Y   Drosophila ananassae   Dana\GF12384 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10593 Y   Drosophila persimilis   Dper\GL17126     Drosophila willistoni   Dwil\GK20678 Y   Drosophila virilis   Dvir\GJ21297 Y   Drosophila mojavensis   Dmoj\GI18926 Y   Drosophila grimshawi   Dgri\GH23101 Y
Orthologs in non-Drosophila Dipterans (EOG6G1MQ8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003837   Anopheles gambiae Malaria mosquito  Agam\AGAP010750   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001302   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001303
Orthologs in non-Dipteran Insects (EOG6RV1M4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55650   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008345   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27099   Atta cephalotes Leafcutter ant  Acep\ACEP18655   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14236   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26982   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14240   Linepithema humile Argentine ant  Lhum\LH18851   Linepithema humile Argentine ant  Lhum\LH14462   Linepithema humile Argentine ant  Lhum\LH22778   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11536   Solenopsis invicta Red fire ant  Sinv\SINV18898   Acyrthosiphon pisum Pea aphid  Apim\ACYPI069453   Bombyx mori Silkmoth  Bmor\BGIBMGA013297   Bombyx mori Silkmoth  Bmor\BGIBMGA013298   Pediculus humanus Human body louse  Phum\PHUM135890   Tribolium castaneum Red flour beetle  Tcas\TC002610
Orthologs in non-Insect Arthropods (EOG6RN8Q7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\matK   Daphnia pulex Water flea  Dpux\ppp2r2a   Daphnia pulex Water flea  Dpux\JGI_V11_246748   Daphnia pulex Water flea  Dpux\ACAC   Daphnia pulex Water flea  Dpux\LMCO   Daphnia pulex Water flea  Dpux\JGI_V11_242970   Daphnia pulex Water flea  Dpux\rbcL   Daphnia pulex Water flea  Dpux\PB2   Daphnia pulex Water flea  Dpux\mt:CoII   Ixodes scapularis Deer tick  Isca\ISCW007202   Ixodes scapularis Deer tick  Isca\ISCW017057   Ixodes scapularis Deer tick  Isca\ISCW017056   Ixodes scapularis Deer tick  Isca\ISCW007204
Orthologs in non-Arthropod Metazoa (EOG67X1FB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\unc-68   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010784gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008850gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015246gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019080gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019879gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000284gn   Danio rerio Zebrafish  Drer\ryr1a   Danio rerio Zebrafish  Drer\ryr2b   Danio rerio Zebrafish  Drer\ryr1b   Danio rerio Zebrafish  Drer\ryr3   Xenopus tropicalis Western clawed frog  Xtro\ryr1   Gallus gallus Domestic chicken  Ggal\RYR2   Gallus gallus Domestic chicken  Ggal\RYR3   Mus musculus House mouse  Mmus\Ryr1   Mus musculus House mouse  Mmus\Lce1b   Mus musculus House mouse  Mmus\Ryr2   Mus musculus House mouse  Mmus\Ryr3   Mus musculus House mouse  Mmus\Lce1a2   Mus musculus House mouse  Mmus\Lce1a1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042830   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000040059   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042622   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042270   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042381   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043238   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042073   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042187   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042685   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043316   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017060   Rattus norvegicus Norway rat  Rnor\LOC685349   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006645   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043434   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042800   Rattus norvegicus Norway rat  Rnor\LOC685363   Rattus norvegicus Norway rat  Rnor\Ryr1   Homo sapiens Human  Hsap\LCE3A   Homo sapiens Human  Hsap\RYR3   Homo sapiens Human  Hsap\RYR1   Homo sapiens Human  Hsap\RYR2
Human Orthologs (4)
Gene OMIM HGNC Hsap\LCE3A     Hsap\RYR3     Hsap\RYR1     Hsap\RYR2
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10606 Drosophila sechellia Dsec\GM21070 Drosophila erecta Dere\GG23389 Drosophila yakuba Dyak\GE19231 Drosophila ananassae Dana\GF12384 Drosophila pseudoobscura pseudoobscura Dpse\GA10593 Drosophila willistoni Dwil\GK20678 Drosophila virilis Dvir\GJ21297 Drosophila mojavensis Dmoj\GI18926 Drosophila grimshawi Dgri\GH23101
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	28919 y1 v1; P{TRiP.HM05130}attP2 29445 y1 v1; P{TRiP.JF03381}attP2 31540 y1 v1; P{TRiP.JF01100}attP2 31695 y1 v1; P{TRiP.JF01101}attP2 6812 y1 w*; Rya-r44F16/CyO, y+ 41516 y1 w*; Mi{MIC}Rya-r44FMI06312/SM6a 10559 y1 w67c23; P{lacW}Rya-r44Fk04913/CyO 20741 y1 w67c23; P{EPgy2}Rya-r44FEY12439/CyO
Harvard	- P{XP}Rya-r44Fd03686
Kyoto	104337 w*; P{GawB}Rya-r44FNP3006 111172 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Rya-r44Fk04913 /CyO y+
Genomic Clones ( 1 )
	BACR02C23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	AT24194 MIP15866
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26063 HL07383 HL07739 RE55540 RE55551 RH13694 RH18627 RH18783 RH22394 RH24308 RH25923 RH27490 RH36402 RH38757 RH40426 RH45789 RH52467 RH54050 RH54394 RH56996 RH59007 RH60409 RH60527 RH61533 RH62989 RH69733 RH73962
Other clones	20058 35251 58698 97024 146953 CK01.3B.E12 CK01.32A.F12 CK00394 DMG4-chr2R.8.025.pred.a DMG5-chr2R.8.019.pred.a EK008039 EK027556 EK054212 EK133839 EK138409 EK181811 EK219228 EK253833 GH09937 GH23816 RP004011647 RP004104914 RP004145959 RP004167044 RP004176384 RP004179141 RP004179642 RP004184296 RP004189793 RP004192756 RP004197331 RP004197553 RP004214636 RP004217384 RP004221975 RP004223576 RP004229456 RP004233033 RP004242401 RP004243539 RP004246597 RP004249031 RP004252701 RP004262143 RP004264205 RP004264213 RP004266431 RP004404256 RP004428945 RP004469893 RP004472095 RP004475437 RP004517147 RP004551818
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011286 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49090
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rya-r44F CG10844 (Misra, 2000.4.8) Source for merge of: Rya-r44F l(2)k04913 (Sullivan et al., 2000)
Additional comments
Other Comments
	Area matching Drosophila Ryanodine receptor gene Acc. No. D17389. (Davies, 2001.3.15) Rya-r44F is required for proper muscle function. (Sullivan et al., 2000) The genomic organisation of the Rya-r44F locus has been characterised. (Takeshima et al., 1994) Isolated from a genomic library using a rabbit skeletal muscle ryanodine receptor cDNA as a probe. (Takeshima et al., 1994) The Drosophila ryanodine receptor gene was cloned by PCR with degenerate oligonucleotides. (Hasan and Rosbash, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057643 NM_057644 NM_057645 NM_057646 NM_001259277 NM_001259278 NM_001259279 NM_001259280 NM_001259281 NM_001259282 RefSeq (Proteins) • NP_476991 NP_476992 NP_476993 NP_476994 NP_001246206 NP_001246207 NP_001246208 NP_001246209 NP_001246210 NP_001246211 DDBJ / EMBL / GenBank • AAF59036 AAM71082 AAM71083 AAM71084 AC007471 AFH07961 AFH07962 AFH07963 AFH07964 AFH07965 AFH07966 AQ025750 AX093878 BAA04212 BAA41469 BAA41470 BAA41471 BF488910 CAA79221 CZ473503 D17389 Z18536 Z50297 Z71006 Entrez Gene - A searchable database of RefSeq genes. • 49090 UniProtKB/Swiss-Prot • Q24498
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SPla/RYanodine receptor subgroup (IPR018355) Ryanodine receptor-related (IPR015925) Intracellular calcium-release channel (IPR000699) Ryanodine receptor Ryr (IPR003032) SPla/RYanodine receptor SPRY (IPR003877) Ion transport domain (IPR005821) Ryanodine Receptor TM 4-6 (IPR009460) EF-hand-like domain (IPR011992) Ryanodine receptor (IPR013333) RyR/IP3R Homology associated domain (IPR013662) B30.2/SPRY domain (IPR001870) Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821) MIR motif (IPR016093) Concanavalin A-like lectin/glucanases superfamily (IPR008985) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00136
Linkouts
	BioGRID - A database of protein and genetic interactions • 71972 DroID - A comprehensive database of gene and protein interactions. • FBgn0011286 DRSC - Results from RNAi screens. • FBgn0011286 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011286 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10844-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011286 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49090 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49090 modMine - Data generated by the modENCODE project. • FBgn0011286
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	CG10844 (Whitfield, 2000.4.28, Whitfield, 2000.4.18, Perkins et al., 2009, Philipps et al., 2004, An et al., 2008, Hughes et al., 2008, Ni et al., 2008, Keleman et al., 2009.8.5, Cammarato et al., 2011, Tsubouchi et al., 2012) DRR (Xu et al., 1999, Takeshima et al., 1994) dry (Sorrentino et al., 2000, Hasan and Rosbash, 1992) DRY (Hasan, 1992.11.20) dRyR (Li et al., 2011) dya   l(2)k00424 (Prokopenko et al., 2000) l(2)k04913 (Mohr and Boswell, 2002, Dockendorff et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) Rya-r44F (Christensen and Cook, 2007.3.22, Franc et al., 2008, Bellen et al., 2011, Li et al., 2011, Klose et al., 2010, Christensen et al., 2008.12.28, Philipps et al., 2004, Michno et al., 2009, Baker et al., 2007, Wasbrough et al., 2010, Tsubouchi et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Rya-R44F (Sinenko et al., 2010) rya-r44F (Cuttell et al., 2008) Rya-r76CD   RyR (Pontig, 2000, Razzaq et al., 2001, Blumenthal, 2001, Vazquez-Martinez et al., 2001, Baumann, 2000, Xu et al., 2000, Vazquez-Martinez et al., 2003, Murmu et al., 2010, Casas-Tinto et al., 2011, Shakiryanova et al., 2011, Shakiryanova et al., 2011, Shakiryanova et al., 2007, Lin et al., 2011) Ryr (Gao et al., 2004, Wang et al., 2003, Sullivan et al., 2000) RYR (Wang and Beckingham, 2002) ryr (Sullivan, 2001.5.1, Sullivan, 2001.4.25) RyRs (Wong et al., 2009) unnamed (Littleton and Ganetzky, 2000)
Name Synonym	ryanodine receptor (Delmas et al., 2004, Montell, 1999, Takeshima, 1994, Shakiryanova et al., 2007) Ryanodine receptor (Vazquez-Martinez et al., 2003, Michno et al., 2009, Lin et al., 2011) Ryanodine receptor 44F (Hurlbut et al., 2009, Harbison et al., 2005, Cammarato et al., 2011, Tsubouchi et al., 2012, Sinenko et al., 2010)
Secondary FlyBase IDs
	FBgn0010268 FBgn0022194
References ( 92 )
Generate a list of	All references relating to this gene ( 92 )
List References by type	Research paper  ( 42 ) Supplementary material  ( 9 ) Review  ( 6 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 10 )
	Gao et al., 2013, Anesthesiology 118(3): 587--601 Drosophila Ryanodine Receptors Mediate General Anesthesia by Halothane. [FBrf0220867] Van Goethem et al., 2012, PLoS ONE 7(2): e31488 The Drosophila TRPP Cation Channel, PKD2 and Dmel/Ced-12 Act in Genetically Distinct Pathways during Apoptotic Cell Clearance. [FBrf0217505] Wilczynski et al., 2012, PLoS Comput. Biol. 8(12): e1002798 Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. [FBrf0220228] Bellen et al., 2011, Genetics 188(3): 731--743 The Drosophila gene disruption project: progress using transposons with distinctive site specificities. [FBrf0214229] Casas-Tinto et al., 2011, Hum. Mol. Genet. 20(11): 2144--2160 The ER stress factor XBP1s prevents amyloid-beta neurotoxicity. [FBrf0214754] Li et al., 2011, Curr. Alzheimer Res. 8(3): 313--322 Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. [FBrf0216250] Lin et al., 2011, Circulation Res. 108(11): 1306--1315 A method to measure myocardial calcium handling in adult Drosophila. [FBrf0213758] Murmu et al., 2011, BMC Neurosci. 12: 105 Calcium-stores mediate adaptation in axon terminals of Olfactory Receptor Neurons in Drosophila. [FBrf0216769] Shakiryanova et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(11): 4477--4481 Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal. [FBrf0213271] Shakiryanova et al., 2011, J. Neurosci. 31(25): 9093--9100 Differential Control of Presynaptic CaMKII Activation and Translocation to Active Zones. [FBrf0213996] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...