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Gene Dmel\Rya-r44F

General Information
Symbol	Dmel\Rya-r44F	Species	D. melanogaster
Name	Ryanodine receptor 44F	Annotation symbol	CG10844
Feature type	protein_coding_gene	FlyBase ID	FBgn0011286
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	RyR, l(2)k04913, dry, DRR
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44F1-44F2	Sequence location	2R:4,747,869..4,775,602 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ryanodine receptor 44F is referred to in FlyBase by the symbol Dmel\Rya-r44F (CG10844, FBgn0011286). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ryanodine-sensitive calcium-release channel activity. There is experimental evidence that it is involved in the biological process: muscle contraction. 13 alleles are reported. The phenotypes of these alleles are annotated with: larva; larval head; embryonic/larval dorsal vessel; presumptive embryonic/larval muscle system; embryonic/larval visceral muscle; embryonic/larval muscle system. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: B30.2/SPRY domain; Concanavalin A-like lectin/glucanase; EF-hand-like domain; Inositol 1,4,5-trisphosphate/ryanodine receptor; Intracellular calcium-release channel; Ion transport; MIR; MIR motif; RyR/IP3R Homology associated domain; Ryanodine Receptor TM 4-6; Ryanodine receptor; Ryanodine receptor Ryr; Ryanodine receptor-related; SPla/RYanodine receptor SPRY; SPla/RYanodine receptor subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633452_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Rya-r44F. Gene sequence location is 2R:4747869..4775602.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Murmu et al., 2011, BMC Neurosci. 12: 105 Sequence features HFA07543 BKN21767
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44F1-44F2   Limits computationally determined from genome sequence between P{PZ}l(2)44DEa05847 and P{lacW}Rya-r44Fk04913
Experimentally Determined Cytological Location
Cytogenetic map Notes References 44F-44F     (Takeshima, 1994) 44F1-44F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 44F1-44F2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 44F-44F   (determined by in situ hybridisation)   (Takeshima et al., 1994)   Stated (in error) to map to 76C--D (by in situ hybridisation).   (Hasan and Rosbash, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rya-r44F for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (AT24194): incomplete CDS (very short).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rya-r44F-RA FBtr0088640  NM_057643   15847   5127 Rya-r44F-RB FBtr0088638  NM_057644   15805   5113 Rya-r44F-RC FBtr0088637  NM_057645   15847   5127 Rya-r44F-RD FBtr0088639  NM_057646   15805   5113 Rya-r44F-RE FBtr0304568     16038   5117 Rya-r44F-RF FBtr0304569     15823   5119 Rya-r44F-RG FBtr0304570     16056   5123 Rya-r44F-RH FBtr0304571     16077   5130 Rya-r44F-RI FBtr0304572     16089   5134 Rya-r44F-RJ FBtr0308083     15811   5115
Additional Transcript Data & Comments
Reported size (kB)	16 (northern blot) (Takeshima et al., 1994) 15 (northern blot) (Hasan and Rosbash, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rya-r44F-PA   FBpp0087721   581.0   5127   5.32     NP_476991   AAF59036 Rya-r44F-PB   FBpp0087719   579.7   5113   5.32     NP_476992   AAM71082 Rya-r44F-PC   FBpp0087718   580.8   5127   5.29     NP_476993   AAM71083 Rya-r44F-PD   FBpp0087720   579.5   5113   5.29     NP_476994   AAM71084 Rya-r44F-PE   FBpp0293110   580.0   5117   5.29       Rya-r44F-PF   FBpp0293111   580.3   5119   5.32       Rya-r44F-PG   FBpp0293112   580.5   5123   5.33       Rya-r44F-PH   FBpp0293113   581.3   5130   5.37       Rya-r44F-PI   FBpp0293114   581.4   5134   5.32       Rya-r44F-PJ   FBpp0300426   579.9   5115   5.40
Additional Polypeptide Data & Comments
Reported size (kDa)	5126, 5112 (aa) (Takeshima et al., 1994) 509 (aa) (Hasan and Rosbash, 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SPla/RYanodine receptor subgroup (IPR018355) Ryanodine receptor-related (IPR015925) Intracellular calcium-release channel (IPR000699) Ryanodine receptor Ryr (IPR003032) MIR (IPR003608) SPla/RYanodine receptor SPRY (IPR003877) Ion transport (IPR005821) Ryanodine Receptor TM 4-6 (IPR009460) EF-hand-like domain (IPR011992) Ryanodine receptor (IPR013333) RyR/IP3R Homology associated domain (IPR013662) B30.2/SPRY domain (IPR001870) Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821) MIR motif (IPR016093) Concanavalin A-like lectin/glucanase (IPR008985)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140702   AA699060   AA699121   AE013599 AAF59036   AE013599 AAM71082   AE013599 AAM71083   AE013599 AAM71084   AC007471   AI113584   AI404189   AI405910   AK257639   AK257821   AK259943   AK260559   AK265824   AK281806   AK282194   AQ025750   AX093878   BF488910   BG632523   BI369375   BI369384   BI565262   BI566685   BI568738   BI574625   BI574941   BI581258   BI581397   BI583719   BI584956   BI604398   BI606989   BI608972   BI615897   BI621165   BI622213   BI622511   BI628560   BI630045   BI631009   BI631115   BI631867   BI634576   BT120191   BT128703   CO177752   CO185322   CO187265   CO264276   CO279230   CO301647   CO307176   CO309773   CZ473503   D17389 BAA04212   D17389 BAA41469   D17389 BAA41470   D17389 BAA41471   EC062787   EC068418   EC084476   EC203489   EC236475   EC240909   EC244595   ES692301   EW713014   FL502408   FL502578   FL502678   GH291314   GH291394   GH941618   GH944182   GH944305   GH945156   GH945584   GH945972   GH946694   GH946987   GH948466   GH948485   GH948848   GH948934   GH949485   GH949680   GH949935   GH950144   GH950938   GH952316   GH955021   GH959135   GH959932   GH963157   GH966746   GH967075   GH967247   GH970341   GH971994   GH977920   GH978227   GH979204   GH979672   GH980052   GH984718   GH985017   HM449918   Z18536 CAA79221   Z50297   Z71006
UniProtKB/Swiss-Prot	Q24498
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 17   somatic muscle   (Hasan and Rosbash, 1992) skeletal muscle of head   (Hasan and Rosbash, 1992) adult stage   subesophageal ganglion   (Hasan and Rosbash, 1992) mesothoracic extracoxal depressor muscle 66   (Hasan and Rosbash, 1992) adult brain   (Hasan and Rosbash, 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Sullivan et al., 2000) embryonic/larval muscle system   (Hasan and Rosbash, 1992) embryonic stage 9 -- 17   mesoderm   (Sullivan et al., 2000, Hasan and Rosbash, 1992) embryonic stage 14   embryonic/larval hypodermal muscle   (Sullivan et al., 2000) embryonic/larval visceral muscle   (Sullivan et al., 2000) adult stage   proboscis muscle   (Hasan and Rosbash, 1992) skeletal muscle of head   (Hasan and Rosbash, 1992) skeletal muscle of leg   (Hasan and Rosbash, 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 15     (Takeshima et al., 1994) Comment:reference states 6-12 hr AEL second instar larval stage     (Takeshima et al., 1994) third instar larval stage     (Takeshima et al., 1994)
Additional Descriptive Data
	Rya-r44F transcripts are detected in RNA from embryos, larvae, and adults, but not in pupal RNA. They are more abundant in RNA from body than head. In embryos, transcripts are first detected in the mesoderm in stage 9. Subsequently, transcripts are found in somatic and cephalic muscle precursors, and later, in all of the somatic muscles and a subset of the cephalic muscles. In adults, Rya-r44F transcripts are expressed maximally in tubular muscles of the thorax, namely the tergotrochanteral muscle and the leg muscles. Expression is also observed in the cortex of the ventral ganglion and brain and in muscles of the head and proboscis. (Hasan and Rosbash, 1992) Expression is high in 6-12 hr embryos, low in second and third instar larvae, and absent from adults and pupae. (Takeshima et al., 1994) Rya-r44F transcript is first detected in the mesoderm at stage 9, and levels increase starting at stage 13. Highest levels are seen in hypodermal and visceral muscles. Expression is detected at lower levels in other tissues, including the CNS. (Sullivan et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011286    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011286 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011286 expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr    1526 embryo 14-16hr    2393 embryo 16-18hr    1906 embryo 18-20hr    1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1    1478 larva L2    1530 larva L3 12hr old    2534 larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP    1561 pupae 3d postWPP    5785 pupae 4d postWPP    3333 adult male 01day    3300 adult male 05day    2512 adult male 30day    1951 adult female 01day    2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr  (115) embryo 06-08hr  (406) embryo 08-10hr  (867) embryo 10-12hr  (857) embryo 12-14hr  (1526) embryo 14-16hr  (2393) embryo 16-18hr  (1906) embryo 18-20hr  (1760) embryo 20-22hr  (1256) embryo 22-24hr  (1220) larva L1  (1478) larva L2  (1530) larva L3 12hr old  (2534) larva L3 puffstage 1-2  (528) larva L3 puffstage 3-6  (422) larva L3 puffstage 7-9  (144) white prepupae new    60 white prepupae 12hr  (209) white prepupae 24hr  (543) pupae 2d postWPP  (1561) pupae 3d postWPP  (5785) pupae 4d postWPP  (3333) adult male 01day  (3300) adult male 05day  (2512) adult male 30day  (1951) adult female 01day  (2040) adult female 05day  (345) adult female 30day  (338) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr  (1526) embryo 14-16hr  (2393) embryo 16-18hr  (1906) embryo 18-20hr  (1760) embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1  1478 larva L2  (1530) larva L3 12hr old  (2534) larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP  (1561) pupae 3d postWPP  (5785) pupae 4d postWPP  (3333) adult male 01day  (3300) adult male 05day  (2512) adult male 30day  (1951) adult female 01day  (2040) adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr    1526 embryo 14-16hr    2393 embryo 16-18hr    1906 embryo 18-20hr    1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1    1478 larva L2    1530 larva L3 12hr old    2534 larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP    1561 pupae 3d postWPP    5785 pupae 4d postWPP    3333 adult male 01day    3300 adult male 05day    2512 adult male 30day    1951 adult female 01day    2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr    1526 embryo 14-16hr    2393 embryo 16-18hr    1906 embryo 18-20hr    1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1    1478 larva L2    1530 larva L3 12hr old    2534 larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP    1561 pupae 3d postWPP    5785 pupae 4d postWPP    3333 adult male 01day    3300 adult male 05day    2512 adult male 30day    1951 adult female 01day    2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011286 expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr    1526 embryo 14-16hr    2393 embryo 16-18hr    1906 embryo 18-20hr    1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1    1478 larva L2    1530 larva L3 12hr old    2534 larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP    1561 pupae 3d postWPP    5785 pupae 4d postWPP    3333 adult male 01day    3300 adult male 05day    2512 adult male 30day    1951 adult female 01day    2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr  115 embryo 06-08hr  (406) embryo 08-10hr  (867) embryo 10-12hr  (857) embryo 12-14hr  (1526) embryo 14-16hr  (2393) embryo 16-18hr  (1906) embryo 18-20hr  (1760) embryo 20-22hr  (1256) embryo 22-24hr  (1220) larva L1  (1478) larva L2  (1530) larva L3 12hr old  (2534) larva L3 puffstage 1-2  (528) larva L3 puffstage 3-6  (422) larva L3 puffstage 7-9  (144) white prepupae new    60 white prepupae 12hr  (209) white prepupae 24hr  (543) pupae 2d postWPP  (1561) pupae 3d postWPP  (5785) pupae 4d postWPP  (3333) adult male 01day  (3300) adult male 05day  (2512) adult male 30day  (1951) adult female 01day  (2040) adult female 05day  (345) adult female 30day  (338) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr  1526 embryo 14-16hr  2393 embryo 16-18hr  1906 embryo 18-20hr  1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1  1478 larva L2  1530 larva L3 12hr old  (2534) larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP  1561 pupae 3d postWPP  (5785) pupae 4d postWPP  (3333) adult male 01day  (3300) adult male 05day  (2512) adult male 30day  1951 adult female 01day  2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr    1526 embryo 14-16hr    2393 embryo 16-18hr    1906 embryo 18-20hr    1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1    1478 larva L2    1530 larva L3 12hr old    2534 larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP    1561 pupae 3d postWPP    5785 pupae 4d postWPP    3333 adult male 01day    3300 adult male 05day    2512 adult male 30day    1951 adult female 01day    2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    98 embryo 04-06hr    115 embryo 06-08hr    406 embryo 08-10hr    867 embryo 10-12hr    857 embryo 12-14hr    1526 embryo 14-16hr    2393 embryo 16-18hr    1906 embryo 18-20hr    1760 embryo 20-22hr    1256 embryo 22-24hr    1220 larva L1    1478 larva L2    1530 larva L3 12hr old    2534 larva L3 puffstage 1-2    528 larva L3 puffstage 3-6    422 larva L3 puffstage 7-9    144 white prepupae new    60 white prepupae 12hr    209 white prepupae 24hr    543 pupae 2d postWPP    1561 pupae 3d postWPP    5785 pupae 4d postWPP    3333 adult male 01day    3300 adult male 05day    2512 adult male 30day    1951 adult female 01day    2040 adult female 05day    345 adult female 30day    338 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011286    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011286 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011286 expression level Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011286 expression level Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    39.225 Larval Midgut no informative data Larval Hindgut    79 Larval Malpighian Tubules    2.6 Larval Fat Body    8.5 Larval Salivary Gland    4 Larval Trachea no informative data Larval Carcass    411.475 Adult Head    71.4 Adult Eye    59.525 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    221.8 Adult Crop    195.7 Adult Midgut    18.6 Adult Hindgut    141.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    228.675 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    25.3 Adult Ovary    5.5 Adult Testis    20.7 Adult Male Accessory Gland    63.9 Adult Carcass    324.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    71.4   NA  Eye    59.525   NA  Brain    188.6   39.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    221.8   NA  Crop    195.7   no informative data  Midgut    18.6   79  Hindgut    141.8   2.6  Malpighian Tubules    no informative data   8.5  Fat Body    no informative data   4  Salivary Gland    8.9   NA  Heart    228.675   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    15.7   NA  InseminatedFemale Spermatheca    25.3   NA  Ovary    5.5   NA  Testis    20.7   NA  Male Accessory Gland    63.9   411.475  Carcass    324.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011286 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10844-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rya-r44F Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)Np3) Rya-r44F16 lethal | recessive Rya-r44Fk00424b Rya-r44Fk04913 Other Phenotypes Allele feeding behavior defective Rya-r44F16 locomotor behavior defective | larval stage Rya-r44F16 Phenotype manifest in Allele embryonic/larval dorsal vessel Rya-r44F16 embryonic/larval muscle system Rya-r44F16 embryonic/larval muscle system (with Df(2R)Np3) Rya-r44F16 embryonic/larval visceral muscle Rya-r44F16 Rya-r44Fk04913 larva Rya-r44F16 larval head Rya-r44F16 presumptive embryonic/larval muscle system Rya-r44FdsRNA.cSa
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Rya-r44F Class Mutagen Stocks Known lesion Rya-r44Fk04913 P-element activity 2 Yes Rya-r44F16 Delta2-3 1 Yes Rya-r44Fd03686 P-element activity 1 -- Rya-r44FNP3006 1 -- Rya-r44Fk00424b P-element activity 0 -- Rya-r44FSH0622 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rya-r44F Class Mutagen Stocks Known lesion Rya-r44FHM05130 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FJF01100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FJF01101 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FJF03381 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rya-r44FdsRNA.cSa in vitro construct - RNAi 0 Yes Rya-r44FGD1882 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rya-r44FKK101716 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC268 (Christensen et al., 2008.12.28) Df(2R)BSC269 (Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22) Df(2R)Np3 (Abmayr, 1998.5.1, Spradling et al., 1999, Prokopenko et al., 2000, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)44CE (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)G75 (BDGP Project Members, 1994-1999) Df(2R)H3C1 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np1 (Abmayr, 1998.5.1, Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np5 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)P14TE (Abmayr, 1998.5.1)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1882} NA P{KK101716} NA P{TRiP.HM05130} NA P{TRiP.JF01100} NA P{TRiP.JF01101} NA P{TRiP.JF03381} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH1495SH1495 No P{lacW}Rya-r44Fk00424b No P{lacW}Rya-r44Fk04913 No P{lacW}Rya-r44FSH0622 No insertion of mobile activating element P{XP}Rya-r44Fd03686 NA insertion of enhancer trap binary system P{GawB}Rya-r44FNP3006 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
muscle contraction inferred from mutant phenotype (assigned by UniProtKB) (Sullivan et al., 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR011992 (FlyBase Curators et al., 2004-) ryanodine-sensitive calcium-release channel activity inferred from sequence or structural similarity with EMBL:U50465 (FlyBase, 1992-) non-traceable author statement (Hasan, 1992.11.20, Takeshima, 1994) traceable author statement (assigned by UniProtKB) (Takeshima et al., 1994)
Biological Process
CV term Evidence References
calcium ion transmembrane transport inferred from electronic annotation with InterPro:IPR000699 (FlyBase Curators et al., 2004-) calcium ion transport traceable author statement (assigned by UniProtKB) (Takeshima et al., 1994) cellular calcium ion homeostasis inferred from electronic annotation with InterPro:IPR009460 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane non-traceable author statement (Takeshima, 1994) integral to membrane inferred from electronic annotation with InterPro:IPR009460 (FlyBase Curators et al., 2004-) non-traceable author statement (assigned by UniProtKB) (Takeshima et al., 1994)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rya-r44F allele Gene References Rya-r44F16 Cam (Wang et al., 2003) Rya-r44Fk04913 peb (Wilk et al., 2004) Pkd2 (Gao et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71972 DroID - A comprehensive database of gene and protein interactions. • FBgn0011286 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49090
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12384 Dere\GG23389 Dgri\GH23101 Dmoj\GI18926 Dpse\GA10593 Dsec\GM21070 Dsim\GD10606 Dvir\GJ21297 Dwil\GK20678 Dyak\GE19231
Curated drosophilid orthologs	Dpse\GA10593
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003837-PA Aedes aegypti (mosquito) AGAP010750-PA Anopheles gambiae (mosquito) XP_392217.3 Apis mellifera (honey bee) 276181 Branchiostoma floridae (lancelet) BGIBMGA013297-PA Bombyx mori (silk worm) ENSBTAP00000036054 Bos taurus (bovine) CN18753 Caenorhabditis brenneri (small nematode) CBP28664 Caenorhabditis briggsae (nematode) CE43332 Caenorhabditis elegans (worm) ENSCAFP00000014764 Canis familiaris (dog) JA16872 Caenorhabditis japonica (nematode) ENSCPOP00000007144 Cavia porcellus (guinea pig) RP48857 Caenorhabditis remanei (nematode) ENSCSAVP00000001532 Ciona savignyi (sedentary tunicate) 159249 Capitella spl (polychaete worm) 310496 Daphnia pulex (daphnia) ENSDARP00000046552 Danio rerio (zebra fish) ENSECAP00000013008 Equus caballus (horse) ENSGACP00000020213 Gymnopilus aculeatus (mushroom) ENSGALP00000017561 Gallus gallus (chicken) ENSP00000355533 Homo sapiens (human) 123762 Lottia gigantea (owl limpet) ENSMODP00000034966 Monodelphis domestica (gray opossum) ENSMMUP00000001423 Macaca mulatta (rhesus monkey) ENSMUSP00000021750 Mus musculus (house mouse) ENSOANP00000016315 Ornithorynchus anatinus (platypus) ENSORLP00000022370 Oryzias latipes (japanese killifish) PHUM001965-PA Pediculus humanus (human body louse) ENSPPYP00000000078 Pongo pygmaeus (orangutan) ENSPTRP00000003630 Pan troglodytes (chimpanzee) ENSRNOP00000023601 Rattus norvegicus (norway rat) Smp_163570 Schistosoma mansoni (trematode parasite) 52741 Trichoplax adhaerens (metazoa) ENSTNIP00000015182 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000038980 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000006174 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11536 NV50164 LH14462 ISCW017056 ISCW017057 ISCW007204 ISCW007202 FBgn0236585 FBgn0222674 FBgn0208429 FBgn0182374 FBgn0175951 JGI_V11_310496 FBgn0070650 FBgn0154731 FBgn0154730 FBgn0141665 FBgn0130558 FBgn0115537 FBgn0089421 CPIJ001303 CPIJ001302 BGIBMGA013298 BGIBMGA013297 GB15169 AGAP010750 AAEL003837 PB26318 PHUM135890 GLEAN_02610
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	28919 y1 v1; P{TRiP.HM05130}attP2 29445 y1 v1; P{TRiP.JF03381}attP2 31540 y1 v1; P{TRiP.JF01100}attP2 31695 y1 v1; P{TRiP.JF01101}attP2 6812 y1 w*; Rya-r44F16/CyO, y+ 10559 y1 w67c23; P{lacW}Rya-r44Fk04913/CyO
Harvard	- P{XP}Rya-r44Fd03686
Kyoto	104337 w*; P{GawB}Rya-r44FNP3006 111172 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Rya-r44Fk04913 /CyO y+
Genomic Clones ( 1 )
	BACR02C23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	AT24194 MIP15866
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26063 HL07383 HL07739 RE55540 RE55551 RH13694 RH18627 RH18783 RH22394 RH24308 RH25923 RH27490 RH36402 RH38757 RH40426 RH45789 RH52467 RH54050 RH54394 RH56996 RH59007 RH60409 RH60527 RH61533 RH62989 RH69733 RH73962
Other clones	20058 35251 58698 97024 146953 CK01.3B.E12 CK01.32A.F12 CK00394 DMG4-chr2R.8.025.pred.a DMG5-chr2R.8.019.pred.a EK008039 EK027556 EK054212 EK133839 EK138409 EK181811 EK219228 EK253833 GH09937 GH23816 RP004011647 RP004104914 RP004145959 RP004167044 RP004176384 RP004179141 RP004179642 RP004184296 RP004189793 RP004192756 RP004197331 RP004197553 RP004214636 RP004217384 RP004221975 RP004223576 RP004229456 RP004233033 RP004242401 RP004243539 RP004246597 RP004249031 RP004252701 RP004262143 RP004264205 RP004264213 RP004266431 RP004404256 RP004428945 RP004469893 RP004472095 RP004475437 RP004517147 RP004551818
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011286 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49090
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rya-r44F CG10844 (Misra, 2000.4.8) Source for merge of: Rya-r44F l(2)k04913 (Sullivan et al., 2000)
Additional comments
Other Comments
	Area matching Drosophila Ryanodine receptor gene Acc. No. D17389. (Davies, 2001.3.15) Rya-r44F is required for proper muscle function. (Sullivan et al., 2000) The genomic organisation of the Rya-r44F locus has been characterised. (Takeshima et al., 1994) Isolated from a genomic library using a rabbit skeletal muscle ryanodine receptor cDNA as a probe. (Takeshima et al., 1994) The Drosophila ryanodine receptor gene was cloned by PCR with degenerate oligonucleotides. (Hasan and Rosbash, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057643 NM_057644 NM_057645 NM_057646 RefSeq (Proteins) • NP_476991 NP_476992 NP_476993 NP_476994 DDBJ / EMBL / GenBank • AAF59036 AAM71082 AAM71083 AAM71084 AC007471 AQ025750 AX093878 BAA04212 BAA41469 BAA41470 BAA41471 BF488910 CAA79221 CZ473503 D17389 Z18536 Z50297 Z71006 Entrez Gene - A searchable database of RefSeq genes. • 49090 UniProtKB/Swiss-Prot • Q24498
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SPla/RYanodine receptor subgroup (IPR018355) Ryanodine receptor-related (IPR015925) Intracellular calcium-release channel (IPR000699) Ryanodine receptor Ryr (IPR003032) MIR (IPR003608) SPla/RYanodine receptor SPRY (IPR003877) Ion transport (IPR005821) Ryanodine Receptor TM 4-6 (IPR009460) EF-hand-like domain (IPR011992) Ryanodine receptor (IPR013333) RyR/IP3R Homology associated domain (IPR013662) B30.2/SPRY domain (IPR001870) Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821) MIR motif (IPR016093) Concanavalin A-like lectin/glucanase (IPR008985)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71972 DroID - A comprehensive database of gene and protein interactions. • FBgn0011286 DRSC - Results from RNAi screens. • FBgn0011286 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011286 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10844-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011286 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49090 InParanoid A subset of ortholog calls from InParanoid. • AAEL003837-PA Aedes aegypti (mosquito) AGAP010750-PA Anopheles gambiae (mosquito) XP_392217.3 Apis mellifera (honey bee) 276181 Branchiostoma floridae (lancelet) BGIBMGA013297-PA Bombyx mori (silk worm) ENSBTAP00000036054 Bos taurus (bovine) CN18753 Caenorhabditis brenneri (small nematode) CBP28664 Caenorhabditis briggsae (nematode) CE43332 Caenorhabditis elegans (worm) ENSCAFP00000014764 Canis familiaris (dog) JA16872 Caenorhabditis japonica (nematode) ENSCPOP00000007144 Cavia porcellus (guinea pig) RP48857 Caenorhabditis remanei (nematode) ENSCSAVP00000001532 Ciona savignyi (sedentary tunicate) 159249 Capitella spl (polychaete worm) 310496 Daphnia pulex (daphnia) ENSDARP00000046552 Danio rerio (zebra fish) ENSECAP00000013008 Equus caballus (horse) ENSGACP00000020213 Gymnopilus aculeatus (mushroom) ENSGALP00000017561 Gallus gallus (chicken) ENSP00000355533 Homo sapiens (human) 123762 Lottia gigantea (owl limpet) ENSMODP00000034966 Monodelphis domestica (gray opossum) ENSMMUP00000001423 Macaca mulatta (rhesus monkey) ENSMUSP00000021750 Mus musculus (house mouse) ENSOANP00000016315 Ornithorynchus anatinus (platypus) ENSORLP00000022370 Oryzias latipes (japanese killifish) PHUM001965-PA Pediculus humanus (human body louse) ENSPPYP00000000078 Pongo pygmaeus (orangutan) ENSPTRP00000003630 Pan troglodytes (chimpanzee) ENSRNOP00000023601 Rattus norvegicus (norway rat) Smp_163570 Schistosoma mansoni (trematode parasite) 52741 Trichoplax adhaerens (metazoa) ENSTNIP00000015182 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000038980 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000006174 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49090 modMine - Data generated by the modENCODE project. • FBgn0011286 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11536 NV50164 LH14462 ISCW017056 ISCW017057 ISCW007204 ISCW007202 FBgn0236585 FBgn0222674 FBgn0208429 FBgn0182374 FBgn0175951 JGI_V11_310496 FBgn0070650 FBgn0154731 FBgn0154730 FBgn0141665 FBgn0130558 FBgn0115537 FBgn0089421 CPIJ001303 CPIJ001302 BGIBMGA013298 BGIBMGA013297 GB15169 AGAP010750 AAEL003837 PB26318 PHUM135890 GLEAN_02610
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG10844 (Whitfield, 2000.4.28, Whitfield, 2000.4.18, Perkins et al., 2009, Philipps et al., 2004, An et al., 2008, Hughes et al., 2008, Ni et al., 2008, Keleman et al., 2009.8.5, Cammarato et al., 2011) DRR (Xu et al., 1999, Takeshima et al., 1994) dry (Sorrentino et al., 2000, Hasan and Rosbash, 1992) DRY (Hasan, 1992.11.20) dya   l(2)k00424 (Prokopenko et al., 2000) l(2)k04913 (Mohr and Boswell, 2002, Dockendorff et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) Rya-r44F (Christensen and Cook, 2007.3.22, Franc et al., 2008, Christensen et al., 2008.12.28, Philipps et al., 2004, Michno et al., 2009, Baker et al., 2007, Wasbrough et al., 2010) rya-r44F (Cuttell et al., 2008) Rya-r76CD   RyR (Pontig, 2000, Razzaq et al., 2001, Blumenthal, 2001, Vazquez-Martinez et al., 2001, Baumann, 2000, Xu et al., 2000, Vazquez-Martinez et al., 2003, Shakiryanova et al., 2007) Ryr (Gao et al., 2004, Wang et al., 2003, Sullivan et al., 2000) RYR (Wang and Beckingham, 2002) ryr (Sullivan, 2001.5.1, Sullivan, 2001.4.25) RyRs (Wong et al., 2009) unnamed (Littleton and Ganetzky, 2000)
Name Synonym	ryanodine receptor (Delmas et al., 2004, Montell, 1999, Takeshima, 1994, Shakiryanova et al., 2007) Ryanodine receptor (Vazquez-Martinez et al., 2003, Michno et al., 2009) Ryanodine receptor 44F (Hurlbut et al., 2009, Harbison et al., 2005, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0010268 FBgn0022194
References ( 71 )
Generate a list of	All references relating to this gene ( 71 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 4 ) Patent  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 1 )
	Murmu et al., 2011, BMC Neurosci. 12: 105 Calcium-stores mediate adaptation in axon terminals of Olfactory Receptor Neurons in Drosophila. [FBrf0216769] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...