Rya-r44F, Ryanodine receptor 44F, l(2)k04913, dry, DRR
Ca2+-induced Ca2+ release channel located in presynaptic endoplasmic reticulum membranes - sustains vesicular mobilization thus enhancing release of transmitters and neuropeptides
Please see the JBrowse view of Dmel\RyR for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
16 (northern blot)
15 (northern blot)
None of the polypeptides share 100% sequence identity.
5126, 5112 (aa)
509 (aa)
Homotetramer.
The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RyR using the Feature Mapper tool.
Comment: reference states 6-12 hr AEL
RyR transcript is first detected in the mesoderm at stage 9, and levels increase starting at stage 13. Highest levels are seen in hypodermal and visceral muscles. Expression is detected at lower levels in other tissues, including the CNS.
Expression is high in 6-12 hr embryos, low in second and third instar larvae, and absent from adults and pupae.
RyR transcripts are detected in RNA from embryos, larvae, and adults, but not in pupal RNA. They are more abundant in RNA from body than head. In embryos, transcripts are first detected in the mesoderm in stage 9. Subsequently, transcripts are found in somatic and cephalic muscle precursors, and later, in all of the somatic muscles and a subset of the cephalic muscles. In adults, RyR transcripts are expressed maximally in tubular muscles of the thorax, namely the tergotrochanteral muscle and the leg muscles. Expression is also observed in the cortex of the ventral ganglion and brain and in muscles of the head and proboscis.
GBrowse - Visual display of RNA-Seq signals
View Dmel\RyR in GBrowse 2
2-59
2-57.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: RyR Rya-r44F
Source for merge of: Rya-r44F CG10844
Source for merge of: Rya-r44F l(2)k04913
FlyBase curator comment: Gene symbol changed from 'Rya-r44F' to 'RyR' because: i) it represents community usage; ii) it mirrors the nomenclature of the vertebrate orthologs; iii) there is only a single RyR-encoding gene in the genome, so there's no need to distinguish this one.
Area matching Drosophila Ryanodine receptor gene Acc. No. D17389.
Rya-r44F is required for proper muscle function.
Isolated from a genomic library using a rabbit skeletal muscle ryanodine receptor cDNA as a probe.
The genomic organisation of the Rya-r44F locus has been characterised.
The Drosophila ryanodine receptor gene was cloned by PCR with degenerate oligonucleotides.
