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Gene Dmel\Snap25

General Information
Symbol	Dmel\Snap25	Species	D. melanogaster
Name	Synapse protein 25	Annotation symbol	CG40452
Feature type	protein_coding_gene	FlyBase ID	FBgn0011288
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	SNAP-25
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map		Sequence location	3L:24,067,329..24,292,305 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Synapse protein 25 is referred to in FlyBase by the symbol Dmel\Snap25 (CG40452, FBgn0011288). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: SNAP receptor activity. There is experimental evidence that it is involved in the biological process: synaptic vesicle priming; synaptic vesicle transport; regulation of short-term neuronal synaptic plasticity. 38 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: SNAP-25; Target SNARE coiled-coil domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1638558_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Snap25. Gene sequence location is 3L:24067329..24292305.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA21236 BKN41488 HFA21228
FB2011_10	References Smith et al., 2007, Science 316(5831): 1586--1591 Transgenic Constructs P{GD14547}
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References 80-80   h47   (Drosophila Heterochromatin Genome Project, 2004)   FlyBase curator comment: FBrf0067338 stated that Snap25 mapped to clone DS04327 and thus cytological location 64E11--65B5, however subsequent analysis by Drosophila Heterochromatin Genome Project authoritatively determined that Snap25 lies in 3L heterochromatin.   (BDGP Project Members, 1994-1999)   FlyBase curator comment: FBrf0127207 stated that Snap25 mapped to 64E--65B, determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones, however subsequent analysis by Drosophila Heterochromatin Genome Project authoritatively determined that Snap25 lies in 3L heterochromatin.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Snap25 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Snap25-RA FBtr0111143  NM_001043176   2184   212 Snap25-RC FBtr0304625     2184   212 Snap25-RD FBtr0304626     2039   151
Additional Transcript Data & Comments
Reported size (kB)	2.3 (northern blot) (Risinger et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Snap25-PA   FBpp0110435   23.7   212   4.24     NP_001036641   EAA46071 Snap25-PC   FBpp0293167   23.7   212   4.20       Snap25-PD   FBpp0293168   16.7   151   4.20
Additional Polypeptide Data & Comments
Reported size (kDa)	212 (aa); 23.7 (kD predicted) (Risinger et al., 1993) 25 (kD observed) (Risinger et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Target SNARE coiled-coil domain (IPR000727) SNAP-25 (IPR000928)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141515   AA567465   AA695857   AABU01002755 EAA46071   AC004349   AI133982   AI387090   AI403350   AI404310   AI514081   AI532011   AI532154   AI533431   AI534313   AI541954   AI542305   AI946243   AY058502   AY094931   BG640949   BG640970   BG641360   BI142157   BI369911   BI564872   BI565236   BI607529   BI611641   BI617142   BI623542   BI626613   BI626889   BI627602   BI637489   BI637903   BI641101   BT023789   BT126217   CK659679   CK661131   CO153745   CO153955   CO176876   CO177045   CO177216   CO178291   CO178335   CO178623   CO178806   CO179250   CO185786   CO187215   CO187773   CO188066   CO188894   CO189011   CO189811   CO190119   CO191125   CO193159   CO196246   CO196589   CO196651   CO261985   CO262220   CO262491   CO262675   CO263347   CO263569   CO264499   CO264576   CO264757   CO264809   CO265600   CO265615   CO268571   CO269566   CO269909   CO270020   CO270285   CO270417   CO270570   CO271848   CO274890   CO274942   CO276287   CO278075   CO278341   CO279622   CO281199   CO283727   CO284305   CO284922   CO285581   CO285606   CO286740   CO286883   CO286920   CO287019   CO287150   CO287963   CO288287   CO288447   CO288474   CO288499   CO288547   CO289595   CO289953   CO290158   CO290776   CO291044   CO291278   CO291356   CO293140   CO293149   CO296237   CO296257   CO297304   CO299380   CO299703   CO300306   CO300497   CO300627   CO300790   CO300901   CO303413   CO303574   CO304412   CO307720   CO309745   CO310667   CO312704   CO312732   CO314821   CO314877   CO316664   CO317363   CO318722   CO319500   CO321579   CO321906   CO322410   CO322487   CO322508   CO323344   CO325308   CO325661   CO326573   CO327806   CO327978   CO327986   CO328447   CO328629   CO331327   CO331421   CO332092   CO332134   CO332318   CO333106   CO333684   CO340164   CO340727   CO341552   CO341946   CO341956   CO342387   CO343746   CO344557   CO344804   CO344959   CO345160   CO345201   CO345299   CO345407   CO345450   DN153816   AE014296 EAA46071   EC058857   EC059290   EC059291   EC062209   EC062444   EC064434   EC064533   EC064901   EC065043   EC069232   EC079400   EC079599   EC080828   EC081894   EC083869   EC083936   EC084288   EC087300   EC088375   EC088614   EC090998   EC091106   EC091108   EC195138   EC198437   EC205098   EC206817   EC213815   EC214461   EC215379   EC217115   EC221054   EC228989   EC230314   EC230480   EC230596   EC230878   EC230974   EC234895   EC235000   EC235013   EC244142   EC244282   EC248524   EC250275   EC256415   L22021   U81146   U81147 AAB39757   U81148 AAB39757   U81149 AAB39757   U81150 AAB39757   U81151 AAB39757   U81152 AAB39757   U81153 AAB39757
UniProtKB/Swiss-Prot	P36975
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 14 -- 17   neuron   (Risinger et al., 1997) ventral nerve cord   (Risinger et al., 1997) adult stage   subesophageal ganglion   (Risinger et al., 1993) thoracico-abdominal ganglion   • perikaryon (Risinger et al., 1993) abdominal neuromere   • perikaryon (Risinger et al., 1993) northern blot Stage Tissue/Position (including subcellular localization) Reference larval stage     (Risinger et al., 1993) adult stage     (Risinger et al., 1993) optic lobe   (Risinger et al., 1993) adult brain   (Risinger et al., 1993)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 14 -- 17   ventral nerve cord   (Risinger et al., 1997) embryonic stage 16   chordotonal organ   (Risinger et al., 1997) adult stage   neuron   • synapse (Heifetz and Wolfner, 2004)
Additional Descriptive Data
	Snap25 protein is detected at high levels starting at embryonic stage 14. Most intense staining is seen in the dorsal extent of the ventral nerve cord, which is rich in synapses, and the esophageal ganglion. At stage 16, chordotonal organs of the PNS also stain for Snap25 protein. (Risinger et al., 1997)
Marker for
	synapse
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011288    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011288 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011288 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP    1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr  (118) embryo 18-20hr  (167) embryo 20-22hr  (260) embryo 22-24hr  (633) larva L1  (379) larva L2  (370) larva L3 12hr old  (110) larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9  (121) white prepupae new    97 white prepupae 12hr  (187) white prepupae 24hr  (279) pupae 2d postWPP  (806) pupae 3d postWPP  (1440) pupae 4d postWPP  (544) adult male 01day  (1052) adult male 05day  (616) adult male 30day  (396) adult female 01day  (233) adult female 05day  (172) adult female 30day  (110) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP  1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP    1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP    1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011288 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP    1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr  118 embryo 18-20hr  (167) embryo 20-22hr  (260) embryo 22-24hr  (633) larva L1  (379) larva L2  (370) larva L3 12hr old  110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9  121 white prepupae new    97 white prepupae 12hr  (187) white prepupae 24hr  (279) pupae 2d postWPP  (806) pupae 3d postWPP  (1440) pupae 4d postWPP  (544) adult male 01day  (1052) adult male 05day  (616) adult male 30day  (396) adult female 01day  (233) adult female 05day  (172) adult female 30day  110 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP  1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP    1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    5 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    26 embryo 14-16hr    20 embryo 16-18hr    118 embryo 18-20hr    167 embryo 20-22hr    260 embryo 22-24hr    633 larva L1    379 larva L2    370 larva L3 12hr old    110 larva L3 puffstage 1-2    71 larva L3 puffstage 3-6    92 larva L3 puffstage 7-9    121 white prepupae new    97 white prepupae 12hr    187 white prepupae 24hr    279 pupae 2d postWPP    806 pupae 3d postWPP    1440 pupae 4d postWPP    544 adult male 01day    1052 adult male 05day    616 adult male 30day    396 adult female 01day    233 adult female 05day    172 adult female 30day    110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011288    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011288 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011288 expression level Tissue   Expression Level Larval Central Nervous System    1102.875 Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head    1373.2 Adult Eye    1423.975 Adult Brain    2587.1 Adult Thoracic-Abdominal Ganglion    3274.8 Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1102.875) Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head  (1373.2) Adult Eye  (1423.975) Adult Brain  (2587.1) Adult Thoracic-Abdominal Ganglion  (3274.8) Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1102.875) Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head  (1373.2) Adult Eye  (1423.975) Adult Brain  (2587.1) Adult Thoracic-Abdominal Ganglion  (3274.8) Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1102.875 Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head    1373.2 Adult Eye    1423.975 Adult Brain    2587.1 Adult Thoracic-Abdominal Ganglion    3274.8 Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011288 expression level Tissue   Expression Level Larval Central Nervous System    1102.875 Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head    1373.2 Adult Eye    1423.975 Adult Brain    2587.1 Adult Thoracic-Abdominal Ganglion    3274.8 Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1102.875) Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head  (1373.2) Adult Eye  (1423.975) Adult Brain  (2587.1) Adult Thoracic-Abdominal Ganglion  (3274.8) Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1102.875 Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head  1373.2 Adult Eye  1423.975 Adult Brain  (2587.1) Adult Thoracic-Abdominal Ganglion  (3274.8) Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1102.875 Larval Midgut    12.2 Larval Hindgut    3.9 Larval Malpighian Tubules    4.8 Larval Fat Body    5.8 Larval Salivary Gland    5.8 Larval Trachea    56.65 Larval Carcass    16.75 Adult Head    1373.2 Adult Eye    1423.975 Adult Brain    2587.1 Adult Thoracic-Abdominal Ganglion    3274.8 Adult Crop    8.8 Adult Midgut    5.1 Adult Hindgut    5.1 Adult Malpighian Tubules    2.9 Adult Fat Body    11.4 Adult Salivary Gland    4.6 Adult Heart    10.275 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    2.6 Adult Testis    3.5 Adult Male Accessory Gland    86.8 Adult Carcass    85.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1373.2   NA  Eye    1423.975   NA  Brain    2587.1   1102.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3274.8   NA  Crop    8.8   12.2  Midgut    5.1   3.9  Hindgut    5.1   4.8  Malpighian Tubules    2.9   5.8  Fat Body    11.4   5.8  Salivary Gland    4.6   NA  Heart    10.275   56.65  Trachea    NA   NA  VirginFemale Spermatheca    5.2   NA  InseminatedFemale Spermatheca    5.7   NA  Ovary    2.6   NA  Testis    3.5   NA  Male Accessory Gland    86.8   16.75  Carcass    85.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011288 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG40452-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3L)1-16) Snap253 Snap2533 Snap2553 Snap2593 Snap25153 lethal | pharate adult stage (with Df(3L)1-16) Snap251-16-0 Snap2514 Snap2516 Snap2522 Snap2527 Snap2534 Snap2542 Snap2544 Snap2546 Snap2548 Snap2552 Snap2570 Snap2587 Snap25114 Snap25124 Snap25125 Snap25126 Snap25132 Snap25133 Snap25147 Snap25164 Snap25695 lethal | pharate adult stage | recessive Snap2514 Snap2544 Snap2546 Snap2548 Snap2552 Snap2587 Snap25114 Snap25124 Snap25125 Snap25126 Snap25132 Snap25133 Snap25147 Snap25164 lethal | recessive Snap251-16-0 Snap253 Snap2516 Snap2522 Snap2527 Snap2533 Snap2534 Snap2542 Snap2553 Snap2570 Snap2593 Snap25153 Snap25695 viable Snap25hs.PW viable, with Scer\GAL4pnr-MD237 Snap25GD14547 Other Phenotypes Allele neuroanatomy defective Snap25ts neurophysiology defective Snap25124 Snap25ts neurophysiology defective | heat sensitive Snap25ts neurophysiology defective | temperature conditional (with Df(3L)1-16) Snap25ts paralytic | heat sensitive Snap25ts paralytic | heat sensitive (with Snap251-16-0) Snap25ts paralytic | heat sensitive (with Snap253) Snap25ts paralytic | heat sensitive (with Snap2514) Snap25ts paralytic | heat sensitive (with Snap2516) Snap25ts paralytic | heat sensitive (with Snap2522) Snap25ts paralytic | heat sensitive (with Snap2527) Snap25ts paralytic | heat sensitive (with Snap2533) Snap25ts paralytic | heat sensitive (with Snap2534) Snap25ts paralytic | heat sensitive (with Snap2542) Snap25ts paralytic | heat sensitive (with Snap2544) Snap25ts paralytic | heat sensitive (with Snap2546) Snap25ts paralytic | heat sensitive (with Snap2548) Snap25ts paralytic | heat sensitive (with Snap2552) Snap25ts paralytic | heat sensitive (with Snap2553) Snap25ts paralytic | heat sensitive (with Snap2570) Snap25ts paralytic | heat sensitive (with Snap2587) Snap25ts paralytic | heat sensitive (with Snap2593) Snap25ts paralytic | heat sensitive (with Snap25114) Snap25ts paralytic | heat sensitive (with Snap25124) Snap25ts paralytic | heat sensitive (with Snap25125) Snap25ts paralytic | heat sensitive (with Snap25126) Snap25ts paralytic | heat sensitive (with Snap25132) Snap25ts paralytic | heat sensitive (with Snap25133) Snap25ts paralytic | heat sensitive (with Snap25147) Snap25ts paralytic | heat sensitive (with Snap25153) Snap25ts paralytic | heat sensitive (with Snap25164) Snap25ts paralytic | heat sensitive (with Snap25695) Snap25ts paralytic | heat sensitive (with Snap25ts) Snap251-16-0 Snap253 Snap2514 Snap2516 Snap2522 Snap2527 Snap2533 Snap2534 Snap2542 Snap2544 Snap2546 Snap2548 Snap2552 Snap2553 Snap2570 Snap2587 Snap2593 Snap25114 Snap25124 Snap25125 Snap25126 Snap25132 Snap25133 Snap25147 Snap25153 Snap25164 Snap25695 paralytic | recessive | heat sensitive Snap25ts Phenotype manifest in Allele neuromuscular junction Snap25124 Snap25ts neuromuscular junction | temperature conditional (with Df(3L)1-16) Snap25ts t-bar Snap25ts
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of Snap25 Class Mutagen Stocks Known lesion Snap251-16-0 X ray 0 -- Snap25114 X ray 0 -- Snap25124 X ray 0 -- Snap25125 X ray 0 -- Snap25126 X ray 0 -- Snap25132 X ray 0 -- Snap25133 X ray 0 -- Snap25147 X ray 0 -- Snap2514 X ray 0 -- Snap25153 X ray 0 -- Snap25164 X ray 0 -- Snap2516 X ray 0 -- Snap2522 X ray 0 -- Snap2527 X ray 0 -- Snap2533 X ray 0 -- Snap2534 X ray 0 -- Snap253 X ray 0 -- Snap2542 X ray 0 -- Snap2544 X ray 0 -- Snap2546 X ray 0 -- Snap2548 X ray 0 -- Snap2552 X ray 0 -- Snap2553 X ray 0 -- Snap25695 ethyl methanesulfonate 0 -- Snap2570 X ray 0 -- Snap2587 X ray 0 -- Snap2593 X ray 0 -- Snap25f06813 0 -- Snap25ts 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Snap25 Class Mutagen Stocks Known lesion Snap25HMS01367 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Snap25JF02615 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Snap25GD14547 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Snap25hs.PW in vitro construct - regulatory fusion 0 Yes Snap25n-syb.PR in vitro construct - regulatory fusion 0 Yes Snap25R206A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Snap25Scer\UAS.T:Disc\RFP-tdTomato in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Snap25T:Avic\GFP-YFP in vitro construct - coding region fusion 0 Yes Snap25WT.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)1-16 (Deitcher, 2001.10.21, Rao et al., 2001) Df(3L)Snap253 (Vilinsky et al., 2002) Df(3L)Snap2533 (Vilinsky et al., 2002) Df(3L)Snap2553 (Vilinsky et al., 2002) Df(3L)Snap25153 (Vilinsky et al., 2002)
Not disrupted in	Df(3L)8A-80 (Deitcher, 2001.10.21)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HMS01367} NA P{TRiP.JF02615} NA P{UAS-Snap25.R206A} NA P{UAS-Snap25.WT} NA heat-shock construct P{hs-Snap25.W} NA characterization construct P{GD14547} NA P{n-syb-Snap25.R} NA P{Snap25-YFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Snap25f06813 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of short-term neuronal synaptic plasticity inferred from direct assay (Kawasaki and Ordway, 2009) synaptic vesicle priming inferred from direct assay (Kawasaki and Ordway, 2009) synaptic vesicle transport inferred from direct assay (Kawasaki and Ordway, 2009)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
SNAP receptor activity inferred from sequence or structural similarity (Littleton, 2000) non-traceable author statement (Littleton et al., 1999) soluble NSF attachment protein activity non-traceable author statement (Niemeyer and Schwarz, 1999)
Biological Process
CV term Evidence References
Golgi to plasma membrane transport inferred from sequence or structural similarity (Littleton, 2000) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic transmission non-traceable author statement (Swiss-Prot Project Members, 1994.6.1) synaptic vesicle docking involved in exocytosis non-traceable author statement (Littleton et al., 1999) vesicle-mediated transport non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (Littleton et al., 1999) synapse non-traceable author statement (Swiss-Prot Project Members, 1994.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Snap25 allele Gene References Snap25124 Snap24 (Vilinsky et al., 2002) Snap25ts Snap24 (Vilinsky et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 78209 DroID - A comprehensive database of gene and protein interactions. • FBgn0011288 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355084
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004559-PA Aedes aegypti (mosquito) AGAP001394-PA Anopheles gambiae (mosquito) XP_394588.3 Apis mellifera (honey bee) XP_001950075.1 Acyrthosiphon pisum (pea aphid) 114832 Branchiostoma floridae (lancelet) 119861 Branchiostoma floridae (lancelet) BGIBMGA005176-PA Bombyx mori (silk worm) CN13284 Caenorhabditis brenneri (small nematode) CBP02328 Caenorhabditis briggsae (nematode) CE16604 Caenorhabditis elegans (worm) ENSCINP00000010147 Ciona intestinalis (sea squirt) JA13982 Caenorhabditis japonica (nematode) CPIJ003323 Culex pipens (mosquito) RP17114 Caenorhabditis remanei (nematode) ENSCSAVP00000007401 Ciona savignyi (sedentary tunicate) 180292 Capitella spl (polychaete worm) 200537 Daphnia pulex (daphnia) ENSDARP00000019054 Danio rerio (zebra fish) ENSDARP00000060029 Danio rerio (zebra fish) ENSGACP00000006059 Gymnopilus aculeatus (mushroom) ENSGACP00000019436 Gymnopilus aculeatus (mushroom) 71107 Hypsipyla robusta (cedar shoot borer) 229104 Nematostella vectensis (starlet anemone) XP_001606157.1 Nasonia vitripennis (wasp) PHUM001097-PA Pediculus humanus (human body louse) PP04228 Pristionchus pacificus (nematode) ENSRNOP00000008734 Rattus norvegicus (norway rat) Smp_034120 Schistosoma mansoni (trematode parasite) NP_999754.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974721.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012609 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000014882 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039934 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13395 NV15197 LH23041 ISCW005594 FBgn0241838 FBgn0232445 FBgn0213155 FBgn0213137 FBgn0211606 FBgn0198403 FBgn0181070 FBgn0178291 JGI_V11_200537 FBgn0081801 FBgn0160824 FBgn0159564 FBgn0147604 FBgn0146517 FBgn0028401 FBgn0127047 FBgn0121824 FBgn0109556 FBgn0105421 FBgn0100186 CPIJ003323 BGIBMGA005176 ACYPI005021 ACYPI003602 GB16958 AGAP001394 AAEL004559 PHUM458270 GLEAN_10177
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	27306 y1 v1; P{TRiP.JF02615}attP2 34377 y1 sc* v1; P{TRiP.HMS01367}attP2
Genomic Clones ( 0 )
cDNA Clones ( 217 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH28821 LD21171 RH50880
Other clones	RH47128
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17523 GH23962 LP17608 LP20301 RE56249 RH18014 RH47379 RH62408 RH62955 RH67611 RH67995 RH68957 RH74613 SD03350 SD03536 SD05236 SD07105 SD07934 SD08579 SD12139 SD12166 SD12682 SD16165 SD19527 SD20051 SD24283
Other clones	15111 28158 29546 30299 30611 31409 32723 47442 53802 61096 62441 62576 82290 82927 84351 102762 104685 104907 107010 118503 121340 122189 162159 174192 214281.61 272517 282213 bs22e07 CK01.8B.C1 CK01.35D.H8 CK01.44A.D3 CK01.52B.G5 CK01.57B.G7 CK01.75A.D6 CK01.81A.H2 CK01.86B.E6 CK01.94A.F5 CK01.96D.C2 CK01.100B.E8 CK01.105C.H8 CK01.111C.H6 CK01.116A.B6 CK01.116A.D5 CK01.116A.E1 CK01889 EC35221 EK002348 EK006334 EK007104 EK010005 EK012123 EK027315 EK033222 EK037111 EK042327 EK042749 EK045227 EK046628 EK050817 EK051443 EK052236 EK052904 EK056328 EK056437 EK057219 EK057610 EK058847 EK063720 EK064152 EK064253 EK064631 EK065047 EK067428 EK068151 EK068529 EK068564 EK068636 EK068844 EK071428 EK072655 EK073223 EK075141 EK075922 EK077252 EK077864 EK083335 EK084721 EK085464 EK086054 EK088264 EK088937 EK092005 EK095016 EK096526 EK097141 EK098160 EK098824 EK099335 EK104932 EK115845 EK116011 EK120258 EK128651 EK129825 EK135516 EK139424 EK139637 EK140252 EK140359 EK143203 EK143223 EK156160 EK164163 EK165721 EK167562 EK169510 EK169545 EK175213 EK176351 EK177912 EK178356 EK178831 EK179418 EK179625 EK185949 EK186754 EK188058 EK188233 EK188256 EK190253 EK196062 EK197042 EK201920 EK201931 EK213204 EK213236 EK216623 EK219026 EK222241 EK229720 EK229810 EK237857 EK238139 EK241408 EK242131 EK244627 EK255411 EK265610 EK267816 EK273541 EK278372 EK291034 EK299256 EK299657 EK302509 EK302561 EK303132 EK305720 EK307663 EN02724 EN03164 EP04227 EP08053 EP08352 EP08363 EP09224 EP10131 EP11225 EP12647 EP13503 EP13521 EP14816 EP17944 EP19508 EP19924 EP21026 EP21463 EP21612 EP21759 EP22005 EP22057 GH11320 GH22769 GH27137 GM04621 HL01306 RH55839
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011288 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355084
Antibody Information
	polyclonal (Risinger et al., 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG17676 CG17884 (FlyBase Genome Annotators, 2002-2003) Source for merge of: Snap25 CG17884 CG17676 (Bayraktaroglu, 2000.4.12)
Additional comments	Annotations CG17676 and CG17884 merged as CG40452 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Snap25 has an evolutionarily conserved and complex gene organisation. The onset of Snap25 expression correlates with a time in neuronal development when synapses begin to be formed and when other synapse-specific genes are switched on. (Risinger et al., 1997) Isolated from a Drosophila head cDNA library using a chicken SNAP-25 cDNA fragment (encoding the 5' half of the coding region) as a probe, under low stringency conditions. (Risinger et al., 1993) Snap25 has been cloned and sequenced, and its RNA expression pattern has been analysed. (Risinger et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001043176 RefSeq (Proteins) • NP_001036641 DDBJ / EMBL / GenBank • AAA16059 AAB39757 AABU01002755 AC004349 EAA46071 EAL24571 L22021 U81146 U81147 U81148 U81149 U81150 U81151 U81152 U81153 Entrez Gene - A searchable database of RefSeq genes. • 3355084 UniProtKB/Swiss-Prot • P36975
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Target SNARE coiled-coil domain (IPR000727) SNAP-25 (IPR000928)
Linkouts
	BioGRID - A database of protein and genetic interactions • 78209 DroID - A comprehensive database of gene and protein interactions. • FBgn0011288 DRSC - Results from RNAi screens. • FBgn0011288 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011288 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG40452-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011288 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355084 InParanoid A subset of ortholog calls from InParanoid. • AAEL004559-PA Aedes aegypti (mosquito) AGAP001394-PA Anopheles gambiae (mosquito) XP_394588.3 Apis mellifera (honey bee) XP_001950075.1 Acyrthosiphon pisum (pea aphid) 114832 Branchiostoma floridae (lancelet) 119861 Branchiostoma floridae (lancelet) BGIBMGA005176-PA Bombyx mori (silk worm) CN13284 Caenorhabditis brenneri (small nematode) CBP02328 Caenorhabditis briggsae (nematode) CE16604 Caenorhabditis elegans (worm) ENSCINP00000010147 Ciona intestinalis (sea squirt) JA13982 Caenorhabditis japonica (nematode) CPIJ003323 Culex pipens (mosquito) RP17114 Caenorhabditis remanei (nematode) ENSCSAVP00000007401 Ciona savignyi (sedentary tunicate) 180292 Capitella spl (polychaete worm) 200537 Daphnia pulex (daphnia) ENSDARP00000019054 Danio rerio (zebra fish) ENSDARP00000060029 Danio rerio (zebra fish) ENSGACP00000006059 Gymnopilus aculeatus (mushroom) ENSGACP00000019436 Gymnopilus aculeatus (mushroom) 71107 Hypsipyla robusta (cedar shoot borer) 229104 Nematostella vectensis (starlet anemone) XP_001606157.1 Nasonia vitripennis (wasp) PHUM001097-PA Pediculus humanus (human body louse) PP04228 Pristionchus pacificus (nematode) ENSRNOP00000008734 Rattus norvegicus (norway rat) Smp_034120 Schistosoma mansoni (trematode parasite) NP_999754.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974721.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012609 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000014882 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039934 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355084 modMine - Data generated by the modENCODE project. • FBgn0011288 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13395 NV15197 LH23041 ISCW005594 FBgn0241838 FBgn0232445 FBgn0213155 FBgn0213137 FBgn0211606 FBgn0198403 FBgn0181070 FBgn0178291 JGI_V11_200537 FBgn0081801 FBgn0160824 FBgn0159564 FBgn0147604 FBgn0146517 FBgn0028401 FBgn0127047 FBgn0121824 FBgn0109556 FBgn0105421 FBgn0100186 CPIJ003323 BGIBMGA005176 ACYPI005021 ACYPI003602 GB16958 AGAP001394 AAEL004559 PHUM458270 GLEAN_10177
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG17676   CG17884   CG40452 (Khanna et al., 2010, Ni et al., 2010.12.1) SNAP-25 (Verstreken and Bellen, 2002, Heifetz and Wolfner, 2004, Xue and Zhang, 2002, Bhattacharya et al., 2002, Vilinsky et al., 2002, Vilinsky et al., 2002, Rivlin and Deitcher, 2001, Rivlin and Deitcher, 2001, Rao et al., 2001, Deitcher, 2001.10.21, Littleton et al., 2001, Vilinsky and Deitcher, 2001, Niemeyer and Schwarz, 2000, Littleton, 2000, Lloyd et al., 2000, Risinger, 1994.1.24, Nie et al., 1999, Wu et al., 1999, Niemeyer and Schwarz, 1999, Tolar and Pallanck, 1998, Washbourne et al., 1997, Wu et al., 1998, Risinger et al., 1997, Weimbs et al., 1997, Risinger et al., 1993, Lagow et al., 2007, Stowers and Isacoff, 2007, Kawasaki and Ordway, 2009, Wang and Chapman, 2010, Megighian et al., 2010, Liu et al., 2011, Kawasaki et al., 2011) snap-25 (Richmond and Broadie, 2002, Risinger, 1996.12.6, Risinger, 1996.12.6) SNAP25 (Drummond et al., 2001, Ohyama et al., 2007) Snap25 (Hiesinger et al., 2005, Smith et al., 2007, Perkins et al., 2009.8.10) snp25 (Tolar and Pallanck, 1998)
Name Synonym	Synapse protein 25 (Khanna et al., 2010) synaptosomal-associated protein 25 (Liu et al., 2011)
Secondary FlyBase IDs
	FBan0040452 FBgn0039960 FBgn0039996
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 5 ) Review  ( 7 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Kawasaki et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(25): E222--E229 The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone. [FBrf0213990] Liu et al., 2011, J. Neurosci. 31(6): 2052--2063 Drosophila Acyl-CoA Synthetase Long-Chain Family Member 4 Regulates Axonal Transport of Synaptic Vesicles and Is Required for Synaptic Development and Transmission. [FBrf0212968] Liu et al., 2010, J. Neurosci. 30(35): 11624--11634 Distinct Presynaptic and Postsynaptic Dismantling Processes of Drosophila Neuromuscular Junctions during Metamorphosis. [FBrf0211694] Megighian et al., 2010, J. Cell Sci. 123(19): 3276--3283 Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction. [FBrf0211825] Wang and Chapman, 2010, J. Biol. Chem. 285(40): 30759--30766 Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. [FBrf0211928] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...