FlyBase Gene Report: Dmel\Taf11

General Information

Symbol

Dmel\Taf11

Species

D. melanogaster

Name

TBP-associated factor 11

Annotation Symbol

CG4079

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011291

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dTAF_II30β, Taf30β, TAF_II30β, TFIID, dTAF_II30

Key Links

Genomic Location

Cytogenetic map

30C7-30C7

Sequence location

2L:9,762,424..9,763,262 [-]

Recombination map

2-36

RefSeq locus

NT_033779 REGION:9762424..9763262

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to RNA polymerase II general transcription initiation factor activity

inferred from direct assay

(Yokomori et al., 1993)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(InterPro Project Members, 2004-)

contributes_to RNA polymerase II general transcription initiation factor activity

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in protein-RNA complex assembly

inferred from physical interaction with FLYBASE:r2d2; FB:FBgn0031951,FLYBASE:AGO2; FB:FBgn0087035

(Liang et al., 2015)

involved_in RNAi-mediated antiviral immune response

inferred from mutant phenotype

(Liang et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in RNA polymerase II preinitiation complex assembly

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR045127

(InterPro Project Members, 2004-)

involved_in transcription initiation at RNA polymerase II promoter

inferred from sequence or structural similarity with HGNC:11544

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with SGD:S000004477

(Aoyagi and Wassarman, 2000)

inferred from electronic annotation with InterPro:IPR006809, InterPro:IPR045127

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Liang et al., 2015)

located_in nucleus

inferred from direct assay

(Liang et al., 2015, Yokomori et al., 1993)

part_of transcription factor TFIID complex

inferred from direct assay

(Yokomori et al., 1993)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred from electronic annotation with InterPro:IPR006809

(InterPro Project Members, 2004-)

part_of transcription factor TFIID complex

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with HGNC:11544

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with SGD:S000004477

(Aoyagi and Wassarman, 2000)

inferred from electronic annotation with InterPro:IPR045127

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

TRANSCRIPTION FACTOR II D

Protein Family (UniProt)

Belongs to the TAF11 family. (P49906)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TRANSCRIPTION FACTOR II D -: The general transcription factor complex Transcription factor II D (TFIID) plays an important role in recruiting the transcription machinery to core promoters. TFIID is a complex composed of TBP and several TBP-associated factors. (Adapted from FBrf0125116 and FBrf0156065).

Protein Function (UniProtKB)

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). Component of the short interfering RNAs (siRNAs)-directed RISC loading complex (siRLC) which acts in the dsRNA-mediated RNA interference (RNAi) pathway by siRNAs into the RNA-induced silencing complex (siRISC), the siRNA then serves as a guide to direct the siRISC to complementary endogenous or viral RNA transcripts for degradation or silencing (PubMed:26257286). Promotes formation of the siRLC by facilitating Dcr-2-R2D2 tetramerization to enhance siRNA binding and siRISC loading activities (PubMed:26257286).

(UniProt, P49906)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Taf11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P49906)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Taf11-RA

FBtr0079924

NM_164871

777

196

Additional Transcript Data and Comments

Reported size (kB)

0.75 (longest cDNA)

(Yokomori et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Taf11-PA

FBpp0079514

22.1

196

4.59

P49906

NP_723484

AAF52806

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

196 (aa); 22 (kD predicted)

(Yokomori et al., 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs) (PubMed:8276241). Interacts with Taf2 and Taf4 (PubMed:8276241). Component of the RISC loading complex (siRLC), composed of at least Dcr-2, r2d2 and Taf11, which loads duplex siRNA onto AGO2 to initiate formation of the RNA-induced silencing complex (siRISC) (PubMed:26257286). Interacts with Dcr-2, r2d2 and AGO2 (PubMed:26257286). Taf11 appears to form a tetramer which facilitates or stabilizes formation of the Dcr-2-r2d2 heterotetramer (PubMed:26257286).

(UniProt, P49906)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P49906

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Taf11 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Taf11_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.17

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Liang et al., 2015)

located_in nucleus

inferred from direct assay

(Liang et al., 2015, Yokomori et al., 1993)

part_of transcription factor TFIID complex

inferred from direct assay

(Yokomori et al., 1993)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Taf11 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Taf11

View exonic expression by tissue for Dmel\Taf11

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011291

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34293/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011291

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011291

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011291

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Taf11

Transgenic constructs containing regulatory region of Taf11

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6024

(Ryder, 2004.4.26)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Taf11^GD4059

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Taf11^GD4059

viable, with Scer\GAL4^Mef2.PR

Taf11^GD4059

viable, with Scer\GAL4^tin.CΔ4

Taf11^GD4059

Other Phenotypes

Allele

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Taf11^GD4059

short lived | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

Taf11^GD4059

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\TAF11

12 of 14

Yes

Hsap\LINC02218

9 of 14

Yes

Hsap\TAF11L2

9 of 14

Yes

Hsap\TAF11L3

7 of 14

Yes

Hsap\TAF11L4

7 of 14

Yes

Hsap\TAF11L5

7 of 14

Yes

Hsap\TAF11L6

7 of 14

Yes

Hsap\TAF11L7

7 of 14

Yes

Hsap\TAF11L8

7 of 14

Yes

Hsap\TAF11L9

7 of 14

Yes

Hsap\TAF11L10

7 of 14

Yes

Hsap\TAF11L11

7 of 14

Yes

Hsap\TAF11L12

7 of 14

Yes

Hsap\TAF11L13

7 of 14

Yes

Hsap\TAF11L14

7 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Taf11

12 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Taf11

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\taf11

5 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\taf11

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\taf-11.1

9 of 14

Yes

Cele\taf-11.2

8 of 14

Yes

Cele\taf-11.3

4 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP005522

9 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\TAF11

9 of 13

Yes

Atha\TAF11b

9 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TAF11

9 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\taf11

10 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Taf11. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TAF11; TATA-box binding protein associated factor 11

12 of 14

600772

LINC02218; long intergenic non-protein coding RNA 2218

9 of 14

TAF11L2; TATA-box binding protein associated factor 11 like 2

9 of 14

TAF11L3; TATA-box binding protein associated factor 11 like 3

7 of 14

TAF11L4; TATA-box binding protein associated factor 11 like 4

7 of 14

TAF11L5; TATA-box binding protein associated factor 11 like 5

7 of 14

TAF11L6; TATA-box binding protein associated factor 11 like 6

7 of 14

TAF11L7; TATA-box binding protein associated factor 11 like 7

7 of 14

TAF11L8; TATA-box binding protein associated factor 11 like 8

7 of 14

TAF11L9; TATA-box binding protein associated factor 11 like 9

7 of 14

TAF11L10; TATA-box binding protein associated factor 11 like 10

7 of 14

TAF11L11; TATA-box binding protein associated factor 11 like 11

7 of 14

TAF11L12; TATA-box binding protein associated factor 11 like 12

7 of 14

TAF11L13; TATA-box binding protein associated factor 11 like 13

7 of 14

TAF11L14; TATA-box binding protein associated factor 11 like 14

7 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Taf11

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Taf11 - AGO2

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Taf11 - Dcr-2

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Taf11 - Dlip3

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Taf11 - NC2β

two hybrid

(Hu et al., 2017.6.13)

Taf11 - Taf1

anti bait coimmunoprecipitation, western blot

(Yokomori et al., 1993)

Taf11 - Taf2

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation

(Yokomori et al., 1993)

Taf11 - Taf4

anti tag coimmunoprecipitation, autoradiography

(Yokomori et al., 1993)

Taf11 - Taf6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Taf11 - Taf9

anti bait coimmunoprecipitation, western blot

(Yokomori et al., 1993)

Taf11 - Tbp

anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining, peptide massfingerprinting

(Chen et al., 1994, Verrijzer et al., 1994, Yokomori et al., 1993)

Taf11 - p53

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Taf11 - r2d2

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Taf11

(Liang et al., 2015)

External Data

Subunit Structure (UniProtKB)

(UniProt, P49906 )

Linkouts

BioGRID - A database of protein and genetic interactions.

60390

DroID - A comprehensive database of gene and protein interactions.

FBgn0011291

MIST (protein-protein) - An integrated Molecular Interaction Database

34293

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Basal transcription factors

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-36

Cytogenetic map

30C7-30C7

Sequence location

2L:9,762,424..9,763,262 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

30C7-30C7

Limits computationally determined from genome sequence between P{lacW}zf30C^k02506&P{EP}und^EP424 and P{lacW}l(2)k06416^k06416&P{lacW}sop^k04603

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-36

(FlyBase, 2016)

2-31.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29270

w¹¹¹⁸; Mi{ET1}Taf11^MB11995

78715

y¹ sc^* v¹ sev²¹; P{TOE.GS02154}attP40

64971

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05845}attP40

65409

Taf11⁵ P{neoFRT}40A/CyO; P{UAS-w-RNAi.K}3, P{GAL4-ninaE.GMR}3, e¹/TM6B, Tb⁺

65410

Taf11¹ P{neoFRT}40A/CyO; P{UAS-w-RNAi.K}3, P{GAL4-ninaE.GMR}3, e¹/TM6B, Tb⁺

FlyORF

F003184

M{UAS-Taf11.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

M2L-2116

y¹ w¹¹¹⁸; Taf11^SK5 P{neoFRT}40A/CyO-Tb

2LG-1682

y² VhaAC39-1^cho-1 v¹; P{U6-Taf11.NIG.sgRNA}attP40/CyO

VDRC

v104017

P{KK107818}VIE-260B

v30442

w¹¹¹⁸; P{GD4059}v30442

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI15907

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011291

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011291

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liang et al., 2015, Yokomori et al., 1993)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Taf11 is part of the RISC loading complex (RLC). It appears to assemble the RLC by facilitating tetramerisation of Dcr-2-r2d2, enhancing RNAi efficiency.

(Liang et al., 2015)

dsRNA has been made from templates generated with primers directed against this gene.

(Marr et al., 2006)

The proteins encoded by Tbp, Taf1, Taf2 and Taf11 are likely peripheral subunits of TFIID.

(Wright et al., 2006)

Identified with: LP03430 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

(BDGP Project Members, 2000-)

Does not interact, in vitro, with human thryroid-hormone receptor-β.

(Petty et al., 1996)

The assembly and purification of various functional Tbp TAF complexes demonstrate that Tbp plus the TAFs is sufficient to replace endogenous TFIID to support activated transcription in vitro.

(Chen et al., 1994)

Taf12 and Taf11 join the TfIID complex through interaction with one or more of the larger subunits and only Taf12 may be in contact with Tbp.

(Yokomori et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (26)

Reported As

Symbol Synonym

CG4079

(National Institute of Genetics Fly Stocks, 2022-, Fan et al., 2017, Keleman et al., 2009.8.5, Perkins et al., 2009, Aoyagi and Wassarman, 2000)

(Liang et al., 2015)

TAF

(Müller and Tora, 2004)

TAF1

(Pennington et al., 2013)

TAF11

(Mussabekova et al., 2017, Liang et al., 2015, Weake et al., 2009, Wright and Tjian, 2009, Marr et al., 2006, Santoso and Kadonaga, 2006, Wright et al., 2006, Tora, 2002)

TAF30b

(Hansen et al., 1997)

TAF30β

(Green, 2000)

TAF_II

(Arnosti, 2002)

TAF_II30β

(Tora, 2002, Wassarman and Sauer, 2001, Adams et al., 2000, Pham et al., 1999, Shen et al., 1998, Tansey and Herr, 1997)

TAF^II30β

(Kennett et al., 2002)

TFIID

(Butler and Kadonaga, 2002, Gu et al., 2002, Hochheimer et al., 2002, Stathopoulos and Levine, 2002, Mizuguchi et al., 2001)

TFIID 28 beta

(Nakatani, 1994.2.8)

TFIID-p28beta

Taf11

(Neves and Eisenman, 2019, Bischof et al., 2018, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Liang et al., 2015)

Taf30β

(Bell and Tora, 1999, Struhl and Moqtaderi, 1998, Verrijzer et al., 1995, Hori and Carey, 1994, Hoey et al., 1993, Yokomori et al., 1993)

Taf_II30β

(Chen et al., 1994)

d30β

(Pugh, 2000)

dTAF_II30

(Mantovani, 1999, Burke and Kadonaga, 1997, Verrijzer et al., 1994)

dTAF_II30β

(Wright et al., 2006, Gangloff et al., 2001, Lively et al., 2001, Veenstra and Wolffe, 2001, Cutforth and Gaul, 1999, Zhou et al., 1998, Goodrich and Tjian, 1994)

dTAFII30

(Deak et al., 1997)

dTAFII30 beta

(Yokomori, 1994.2.25)

dTAFII30β

(Saurin et al., 2001)

taf11

(Fan et al., 2017)

Name Synonyms

TBP-associated factor

(Schuettengruber et al., 2007)

TBP-associated factor 11

TBP-associated factor 30kD subunit β

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34293

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P49906

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P49906

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P49906

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011291

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34293/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011291

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011291

FlyMine - An integrated database for Drosophila genomics

FBgn0011291

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4079

MARRVEL_MODEL - MARRVEL (model organism gene)

34293

Linkouts

BioGRID - A database of protein and genetic interactions.

60390

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011291

DroID - A comprehensive database of gene and protein interactions.

FBgn0011291

DRSC - Results frm RNAi screens

FBgn0011291

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Taf11_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011291

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011291

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011291

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003938

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Basal transcription factors

MIST (protein-protein) - An integrated Molecular Interaction Database

34293

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (88)

The following external sites may use different assemblies or annotations than FlyBase.

1.17

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