FlyBase Gene Report: Dmel\Taf11

General Information

Symbol

Dmel\Taf11

Species

D. melanogaster

Name

TBP-associated factor 11

Annotation Symbol

CG4079

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011291

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Snapshot

TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dTAF_II30β, Taf30β, TAF_II30β, TFIID, dTAF_II30

Key Links

Genomic Location

Cytogenetic map

30C7-30C7

Sequence location

2L:9,762,424..9,763,262 [-]

Recombination map

2-36

RefSeq locus

NT_033779 REGION:9762424..9763262

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

TRANSCRIPTION FACTOR II D

Protein Family (UniProt)

Belongs to the TAF11 family. (P49906)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

contributes_to RNA polymerase II general transcription initiation factor activity; transcription factor binding

Predictions / Assertions

protein heterodimerization activity; transcription coactivator activity; transcription factor binding

Summaries

Gene Group (FlyBase)

TRANSCRIPTION FACTOR II D -: The general transcription factor complex Transcription factor II D (TFIID) plays an important role in recruiting the transcription machinery to core promoters. TFIID is a complex composed of TBP and several TBP-associated factors. (Adapted from FBrf0125116 and FBrf0156065).

Protein Function (UniProtKB)

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

(UniProt, P49906)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Taf11 or the JBrowse view of Dmel\Taf11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Taf11-RA

FBtr0079924

NM_164871

777

196

Additional Transcript Data and Comments

Reported size (kB)

0.75 (longest cDNA)

(Yokomori et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Taf11-PA

FBpp0079514

22.1

196

4.59

NP_723484

AAF52806

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

196 (aa); 22 (kD predicted)

(Yokomori et al., 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Taf2 and Taf4.

(UniProt, P49906)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P49906

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Taf11 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Taf11_1

Linkouts

Gene Ontology (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

contributes_to RNA polymerase II general transcription initiation factor activity

inferred from direct assay

(Yokomori et al., 1993)

transcription factor binding

inferred from physical interaction with FLYBASE:Taf1; FB:FBgn0010355

(Yokomori et al., 1993)

inferred from physical interaction with FLYBASE:Taf2; FB:FBgn0011836

(Yokomori et al., 1993)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

transcription coactivator activity

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(assigned by GO_Central )

(Gaudet et al., 2011)

transcription factor binding

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

positive regulation of RNA interference

inferred from mutant phenotype

(Liang et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

RNA polymerase II preinitiation complex assembly

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(assigned by GO_Central )

(Gaudet et al., 2011)

transcription initiation from RNA polymerase II promoter

inferred from sequence or structural similarity with HGNC:11544

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with SGD:S000004477

(Aoyagi and Wassarman, 2000)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Liang et al., 2015)

nucleus

inferred from direct assay

(Liang et al., 2015, Yokomori et al., 1993)

RISC-loading complex

inferred from direct assay

(Liang et al., 2015)

transcription factor TFIID complex

inferred from direct assay

(Yokomori et al., 1993)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

transcription factor TFIID complex

inferred from sequence or structural similarity with HGNC:11544

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with SGD:S000004477

(Aoyagi and Wassarman, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000325119

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Liang et al., 2015)

nucleus

inferred from direct assay

(Liang et al., 2015, Yokomori et al., 1993)

RISC-loading complex

inferred from direct assay

(Liang et al., 2015)

transcription factor TFIID complex

inferred from direct assay

(Yokomori et al., 1993)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Taf11 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Taf11

View exonic expression by tissue for Dmel\Taf11

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011291

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0011291

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4079-RA

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Taf11

Transgenic constructs containing regulatory region of Taf11

Deletions and Duplications ( 1 )

Disrupted in

Df(2L)Exel6024

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Taf11^GD4059

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Taf11^GD4059

viable, with Scer\GAL4^Mef2.PR

Taf11^GD4059

viable, with Scer\GAL4^tin.CΔ4

Taf11^GD4059

Other Phenotypes

Allele

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Taf11^GD4059

short lived | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

Taf11^GD4059

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\TAF11

13 of 15

Yes

Hsap\SNURF

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Taf11

12 of 15

Yes

Mmus\Snrpb

1 of 15

Mmus\Snurf

1 of 15

Rattus norvegicus (Norway rat) (3)

Rnor\Taf11

12 of 13

Yes

Rnor\Snrpb

1 of 13

Rnor\Snrpn

1 of 13

Xenopus tropicalis (Western clawed frog) (1)

Xtro\taf11

6 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\taf11

13 of 15

Yes

Drer\snrpb

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\taf-11.1

8 of 15

Yes

Cele\taf-11.2

8 of 15

Yes

Cele\taf-11.3

7 of 15

Yes

Cele\snr-2

1 of 15

Arabidopsis thaliana (thale-cress) (2)

Atha\TAF11

6 of 9

Yes

Atha\TAF11b

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TAF11

8 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\taf11

10 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190H4T )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Taf11

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17941

Drosophila persimilis

Dper\GL19212

Drosophila willistoni

Dwil\GK24821

Drosophila virilis

Dvir\GJ14786

Drosophila mojavensis

Dmoj\GI18207

Drosophila grimshawi

Dgri\GH25071

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C2U )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17005966

Musca domestica

House fly

Mdoa\17025338

Glossina morsitans

Tsetse fly

Gmor\GMOY010593

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10814

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06971

Mayetiola destructor

Hessian fly

Mdes\Mdes012080

Mayetiola destructor

Hessian fly

Mdes\Mdes007625

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010019

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002377

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014850

Anopheles darlingi

American malaria mosquito

Adar\ADAC001952

Anopheles darlingi

American malaria mosquito

Adar\ADAC001953

Anopheles gambiae

Malaria mosquito

Agam\AGAP005522

Anopheles gambiae

Malaria mosquito

Agam\AGAP005523

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005672

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006616

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MDU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008893

Bombyx mori

Silkmoth

Bmor\BGIBMGA003004

Danaus plexippus

Monarch butterfly

Dple\DPOGS200432-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS211128-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002502

Heliconius melpomene

Postman butterfly

Hmel\HMEL017232

Apis florea

Little honeybee

Aflo\2797666564

Apis florea

Little honeybee

Aflo\2792435892

Apis mellifera

Western honey bee

Amel\GB45433

Apis mellifera

Western honey bee

Amel\Taf11

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24455

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15347

Bombus terrestris

Buff-tailed bumblebee

Bter\15212017

Bombus terrestris

Buff-tailed bumblebee

Bter\15211870

Linepithema humile

Argentine ant

Lhum\LH19988

Linepithema humile

Argentine ant

Lhum\LH16436

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00131e

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000bed

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025142

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003952

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04023

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12384

Tribolium castaneum

Red flour beetle

Tcas\TC003938

Tribolium castaneum

Red flour beetle

Tcas\TC030631

Pediculus humanus

Human body louse

Phum\PHUM581970

Pediculus humanus

Human body louse

Phum\PHUM462590

Rhodnius prolixus

Kissing bug

Rpro\RPRC013967

Rhodnius prolixus

Kissing bug

Rpro\RPRC003374

Cimex lectularius

Bed bug

Clec\CLEC005207

Cimex lectularius

Bed bug

Clec\CLEC001249

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005279

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006936

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006026

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09365

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04172

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0MEC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012369

Strigamia maritima

European centipede

Smar\SMAR008663

Ixodes scapularis

Black-legged tick

Isca\ISCW014707

Ixodes scapularis

Black-legged tick

Isca\ISCW007743

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74614.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58804.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur11g00110

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g04370

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g03700

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_47763

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_305959

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_100237

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0Y7H )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-TfIID11

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SnrpB

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SnrpB_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000016042

Gallus gallus

Domestic chicken

Ggal\SNRPB

Gallus gallus

Domestic chicken

Ggal\TAF11

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

SmB

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TAF11; TATA-box binding protein associated factor 11

13 of 15

600772

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Taf11

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Taf11 - AGO2

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Taf11 - Dcr-2

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Taf11 - Dlip3

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Taf11 - NC2β

two hybrid

(Hu et al., 2017.6.13)

Taf11 - Taf1

anti bait coimmunoprecipitation, western blot

(Yokomori et al., 1993)

Taf11 - Taf2

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation

(Yokomori et al., 1993)

Taf11 - Taf4

anti tag coimmunoprecipitation, autoradiography

(Yokomori et al., 1993)

Taf11 - Taf6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Taf11 - Tbp

anti bait coimmunoprecipitation, molecular weight estimation by staining, western blot, peptide massfingerprinting

(Chen et al., 1994, Verrijzer et al., 1994, Yokomori et al., 1993)

Taf11 - e(y)1

anti bait coimmunoprecipitation, western blot

(Yokomori et al., 1993)

Taf11 - p53

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Taf11 - r2d2

anti tag coimmunoprecipitation, anti tag western blot

(Liang et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Taf11

(Liang et al., 2015)

External Data

Subunit Structure (UniProtKB)

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Taf2 and Taf4.

(UniProt, P49906 )

Linkouts

BioGRID - A database of protein and genetic interactions.

60390

DroID - A comprehensive database of gene and protein interactions.

FBgn0011291

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34293

MIST (protein-protein) - An integrated Molecular Interaction Database

Taf11

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Basal transcription factors

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-36

Cytogenetic map

30C7-30C7

Sequence location

2L:9,762,424..9,763,262 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

30C7-30C7

Limits computationally determined from genome sequence between P{lacW}zf30C^k02506&P{EP}und^EP424 and P{lacW}l(2)k06416^k06416&P{lacW}sop^k04603

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-36

(FlyBase, 2016)

2-31.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

29270

w¹¹¹⁸; Mi{ET1}Taf11^MB11995

78715

y¹ sc^* v¹ sev²¹; P{TOE.GS02154}attP40

64971

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05845}attP40

65409

Taf11⁵ P{neoFRT}40A/CyO; P{UAS-w-dsRNA.K}3, P{GAL4-ninaE.GMR}3, e¹/TM6B, Tb⁺

65410

Taf11¹ P{neoFRT}40A/CyO; P{UAS-w-dsRNA.K}3, P{GAL4-ninaE.GMR}3, e¹/TM6B, Tb⁺

FlyORF

F003184

M{UAS-Taf11.ORF.3xHA.GW}ZH-86Fb

VDRC

v104017

P{KK107818}VIE-260B

v30442

w¹¹¹⁸; P{GD4059}v30442

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

LP03430

Other clones

FI15907

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011291

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011291

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34293

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liang et al., 2015, Yokomori et al., 1993)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Taf11 is part of the RISC loading complex (RLC). It appears to assemble the RLC by facilitating tetramerisation of Dcr-2-r2d2, enhancing RNAi efficiency.

(Liang et al., 2015)

dsRNA has been made from templates generated with primers directed against this gene.

(Marr et al., 2006)

The proteins encoded by Tbp, Taf1, Taf2 and Taf11 are likely peripheral subunits of TFIID.

(Wright et al., 2006)

Identified with: LP03430 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

(BDGP Project Members, 2000-)

Does not interact, in vitro, with human thryroid-hormone receptor-β.

(Petty et al., 1996)

The assembly and purification of various functional Tbp TAF complexes demonstrate that Tbp plus the TAFs is sufficient to replace endogenous TFIID to support activated transcription in vitro.

(Chen et al., 1994)

Taf12 and Taf11 join the TfIID complex through interaction with one or more of the larger subunits and only Taf12 may be in contact with Tbp.

(Yokomori et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34293

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P49906

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011291

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011291

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Taf11_1

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34293

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003938

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4079

modMine - A data warehouse for the modENCODE project

FBgn0011291

Linkouts

BioGRID - A database of protein and genetic interactions.

60390

DroID - A comprehensive database of gene and protein interactions.

FBgn0011291

DRSC - Results frm RNAi screens

FBgn0011291

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0011291

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4079-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011291

FlyMine - An integrated database for Drosophila genomics

FBgn0011291

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34293

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Basal transcription factors

MIST (protein-protein) - An integrated Molecular Interaction Database

Taf11

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (26)

Reported As

Symbol Synonym

CG4079

(Fan et al., 2017, Keleman et al., 2009.8.5, Perkins et al., 2009, Aoyagi and Wassarman, 2000)

(Liang et al., 2015)

TAF

(Müller and Tora, 2004)

TAF1

(Pennington et al., 2013)

TAF11

(Mussabekova et al., 2017, Liang et al., 2015, Weake et al., 2009, Wright and Tjian, 2009, Marr et al., 2006, Santoso and Kadonaga, 2006, Wright et al., 2006, Tora, 2002)

TAF30b

(Hansen et al., 1997)

TAF30β

(Green, 2000)

TAF_II

(Arnosti, 2002)

TAF_II30β

(Tora, 2002, Wassarman and Sauer, 2001, Adams et al., 2000, Pham et al., 1999, Shen et al., 1998, Tansey and Herr, 1997)

TAF^II30β

(Kennett et al., 2002)

TFIID

(Butler and Kadonaga, 2002, Gu et al., 2002, Hochheimer et al., 2002, Stathopoulos and Levine, 2002, Mizuguchi et al., 2001)

TFIID 28 beta

(Nakatani, 1994.2.8)

TFIID-p28beta

Taf11

(Neves and Eisenman, 2019, Bischof et al., 2018, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Liang et al., 2015)

Taf30β

(Bell and Tora, 1999, Struhl and Moqtaderi, 1998, Verrijzer et al., 1995, Hori and Carey, 1994, Hoey et al., 1993, Yokomori et al., 1993)

Taf_II30β

(Chen et al., 1994)

d30β

(Pugh, 2000)

dTAF_II30

(Mantovani, 1999, Burke and Kadonaga, 1997, Verrijzer et al., 1994)

dTAF_II30β

(Wright et al., 2006, Gangloff et al., 2001, Lively et al., 2001, Veenstra and Wolffe, 2001, Cutforth and Gaul, 1999, Zhou et al., 1998, Goodrich and Tjian, 1994)

dTAFII30

(Deak et al., 1997)

dTAFII30 beta

(Yokomori, 1994.2.25)

dTAFII30β

(Saurin et al., 2001)

taf11

(Fan et al., 2017)

Name Synonyms

TBP-associated factor

(Schuettengruber et al., 2007)

TBP-associated factor 11

TBP-associated factor 30kD subunit β

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (84)

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