FB2018_06, released Dec 21, 2018 All FlyBase archives from FB2014_04 until FB2018_05 are temporarily unavailable.

Gene: Dmel\Taf11

Help
Open All Close All
General Information
Symbol
Dmel\Taf11
Species
D. melanogaster
Name
TBP-associated factor 11
Annotation Symbol
CG4079
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011291
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
TBP-associated factor 11 is part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex. [Date last reviewed: 2016-06-30]
Other Summaries
Also Known As
Taf30β, dTAFII30β, TAFII30β, TFIID, dTAFII30
Key Links
Genomic Location
Cytogenetic map
30C7-30C7
Sequence location
2L:9,762,424..9,763,262 [-]
Recombination map
2-36
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the TAF11 family. (P49906)
Protein Domains/Motifs
InterPro
TAFII28-like protein; Histone-fold
Molecular Function (see GO section for details)
Experimental Evidence
transcription factor binding
Predictions / Assertions
protein heterodimerization activity; transcription coactivator activity; transcription factor binding
Summaries
Gene Group Membership
TRANSCRIPTION FACTOR II D -
The general transcription factor complex Transcription factor II D (TFIID) plays an important role in recruiting the transcription machinery to core promoters. TFIID is a complex composed of TBP and several TBP-associated factors. (Adapted from FBrf0125116 and FBrf0156065).
UniProt Contributed Function Data
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
(UniProt, P49906)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Taf11 or the JBrowse view of Dmel\Taf11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Taf11-RA
FBtr0079924
NM_164871
777
196
Additional Transcript Data and Comments
Reported size (kB)
0.75 (longest cDNA)
(Yokomori et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Taf11-PA
FBpp0079514
22.1
196
4.59
NP_723484
AAF52806
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
196 (aa); 22 (kD predicted)
(Yokomori et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)
Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Taf2 and Taf4.
(UniProt, P49906)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Taf11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
transcription factor binding
inferred from physical interaction with FLYBASE:Taf1; FB:FBgn0010355
(Yokomori et al., 1993)
inferred from physical interaction with FLYBASE:Taf2; FB:FBgn0011836
(Yokomori et al., 1993)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
protein heterodimerization activity
inferred from electronic annotation with InterPro:IPR009072
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN000325119
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN000325119
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
positive regulation of protein tetramerization
inferred from direct assay
(Liang et al., 2015)
positive regulation of RNA interference
inferred from mutant phenotype
(Liang et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
RNA polymerase II preinitiation complex assembly
inferred from biological aspect of ancestor with PANTHER:PTN000325119
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription initiation from RNA polymerase II promoter
inferred from sequence or structural similarity with HGNC:11544
(Aoyagi and Wassarman, 2000)
inferred from sequence or structural similarity with SGD:S000004477
(Aoyagi and Wassarman, 2000)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Liang et al., 2015)
nucleus
inferred from direct assay
(Liang et al., 2015, Yokomori et al., 1993)
RISC-loading complex
inferred from direct assay
(Liang et al., 2015)
transcription factor TFIID complex
inferred from direct assay
(Yokomori et al., 1993)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
transcription factor TFIID complex
inferred from sequence or structural similarity with HGNC:11544
(Aoyagi and Wassarman, 2000)
inferred from sequence or structural similarity with SGD:S000004477
(Aoyagi and Wassarman, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000325119
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Liang et al., 2015)
nucleus
inferred from direct assay
(Liang et al., 2015, Yokomori et al., 1993)
RISC-loading complex
inferred from direct assay
(Liang et al., 2015)
transcription factor TFIID complex
inferred from direct assay
(Yokomori et al., 1993)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Taf11 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Allele of Taf11
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Taf111
1
Yes
Taf115
1
Yes
Taf11MB11995
    1
    Yes
    Taf112
    0
    Yes
    Taf113
    0
    Yes
    Taf114
    0
    Yes
    Taf116
    0
    Yes
    Taf117
    0
    Yes
    Taf11c04450
    0
    Yes
    Other relevant insertions
    Transgenic Constructs ( 6 )
    Deletions and Duplications ( 1 )
    Summary of Phenotypes
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (2)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Hsap\TAF11
    13 of 15
    Yes
    Yes
    Hsap\SNURF
    1 of 15
    No
    No
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (3)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Mmus\Taf11
    12 of 15
    Yes
    Yes
    Mmus\Snrpb
    1 of 15
    No
    No
    Mmus\Snurf
    1 of 15
    No
    No
    Rattus norvegicus (Norway rat) (3)
    Rnor\Taf11
    12 of 13
    Yes
    Yes
    Rnor\Snrpb
    1 of 13
    No
    No
    Rnor\Snrpn
    1 of 13
    No
    No
    Xenopus tropicalis (Western clawed frog) (1)
    Xtro\taf11
    6 of 12
    Yes
    Yes
    Danio rerio (Zebrafish) (2)
    Drer\taf11
    13 of 15
    Yes
    Yes
    Drer\snrpb
    1 of 15
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (4)
    Cele\taf-11.1
    8 of 15
    Yes
    Yes
    Cele\taf-11.2
    8 of 15
    Yes
    Yes
    Cele\taf-11.3
    7 of 15
    No
    Yes
    Cele\snr-2
    1 of 15
    No
    No
    Arabidopsis thaliana (thale-cress) (2)
    Atha\TAF11
    6 of 9
    Yes
    Yes
    Atha\TAF11b
    5 of 9
    No
    Yes
    Saccharomyces cerevisiae (Brewer's yeast) (1)
    Scer\TAF11
    8 of 15
    Yes
    Yes
    Schizosaccharomyces pombe (Fission yeast) (1)
    Spom\taf11
    10 of 12
    Yes
    Yes
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190H4T )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila melanogaster
    fruit fly
    Dmel\Taf11
    Drosophila suzukii
    Spotted wing Drosophila
    Dsuz\DS10_00001614
    Drosophila simulans
    Dsim\GD22339
    Drosophila sechellia
    Dsec\GM12298
    Drosophila erecta
    Dere\GG24011
    Drosophila yakuba
    Dyak\GE10358
    Drosophila ananassae
    Dana\GF21885
    Drosophila pseudoobscura pseudoobscura
    Dpse\GA17941
    Drosophila persimilis
    Dper\GL19212
    Drosophila willistoni
    Dwil\GK24821
    Drosophila virilis
    Dvir\GJ14786
    Drosophila mojavensis
    Dmoj\GI18207
    Drosophila grimshawi
    Dgri\GH25071
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C2U )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Mdoa\17005966
    Musca domestica
    House fly
    Mdoa\17025338
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY010593
    Lucilia cuprina
    Australian sheep blowfly
    Lcup\FF38_10814
    Lucilia cuprina
    Australian sheep blowfly
    Lcup\FF38_06971
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes012080
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes007625
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL010019
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL002377
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL014850
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC001952
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC001953
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP005522
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP005523
    Culex quinquefasciatus
    Southern house mosquito
    Cqui\CPIJ005672
    Culex quinquefasciatus
    Southern house mosquito
    Cqui\CPIJ006616
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MDU )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA008893
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA003004
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS200432-PA
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS211128-PA
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL002502
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL017232
    Apis florea
    Little honeybee
    Aflo\2797666564
    Apis florea
    Little honeybee
    Aflo\2792435892
    Apis mellifera
    Western honey bee
    Amel\GB45433
    Apis mellifera
    Western honey bee
    Amel\Taf11
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP24455
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP15347
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15212017
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15211870
    Linepithema humile
    Argentine ant
    Lhum\LH19988
    Linepithema humile
    Argentine ant
    Lhum\LH16436
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:00131e
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:000bed
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG025142
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG003952
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_04023
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_12384
    Tribolium castaneum
    Red flour beetle
    Tcas\TC003938
    Tribolium castaneum
    Red flour beetle
    Tcas\TC030631
    Pediculus humanus
    Human body louse
    Phum\PHUM581970
    Pediculus humanus
    Human body louse
    Phum\PHUM462590
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC013967
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC003374
    Cimex lectularius
    Bed bug
    Clec\CLEC005207
    Cimex lectularius
    Bed bug
    Clec\CLEC001249
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI005279
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI006936
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI006026
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_09365
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_04172
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0MEC )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Smar\SMAR012369
    Strigamia maritima
    European centipede
    Smar\SMAR008663
    Ixodes scapularis
    Black-legged tick
    Isca\ISCW014707
    Ixodes scapularis
    Black-legged tick
    Isca\ISCW007743
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM74614.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM58804.1
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur11g00110
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur06g04370
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur06g03700
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_47763
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_305959
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_100237
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0Y7H )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-TfIID11
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-SnrpB
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-SnrpB_1
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000016042
    Gallus gallus
    Domestic chicken
    Ggal\SNRPB
    Gallus gallus
    Domestic chicken
    Ggal\TAF11
    Human Disease Model Data
    FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 0 )
      Allele
      Disease
      Evidence
      References
      Interactions ( 0 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      Complementation?
      Transgene?
      TAF11; TATA-box binding protein associated factor 11
      13 of 15
      600772
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please look at the Interaction Group reports for full details of the physical interactions
        protein-protein
        Interacting group
        Assay
        References
        Taf11
        anti tag coimmunoprecipitation, anti tag western blot
        (Liang et al., 2015)
        Taf11 - AGO2
        anti tag coimmunoprecipitation, anti tag western blot
        (Liang et al., 2015)
        Taf11 - Dcr-2
        anti tag coimmunoprecipitation, anti tag western blot
        (Liang et al., 2015)
        Taf11 - Dlip3
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Taf11 - NC2β
        two hybrid
        (Hu et al., 2017.6.13)
        Taf11 - Taf1
        anti bait coimmunoprecipitation, western blot
        (Yokomori et al., 1993)
        Taf11 - Taf2
        anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
        (Yokomori et al., 1993)
        Taf11 - Taf4
        anti tag coimmunoprecipitation, autoradiography
        (Yokomori et al., 1993)
        Taf11 - Taf6
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Weake et al., 2009)
        Taf11 - Tbp
        anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining, peptide massfingerprinting
        (Chen et al., 1994, Verrijzer et al., 1994, Yokomori et al., 1993)
        Taf11 - e(y)1
        anti bait coimmunoprecipitation, western blot
        (Yokomori et al., 1993)
        Taf11 - p53
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Taf11 - r2d2
        anti tag coimmunoprecipitation, anti tag western blot
        (Liang et al., 2015)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        w
        suppressible
        Taf11
        (Liang et al., 2015)
        External Data
        Subunit Structure (UniProtKB)
        Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Taf2 and Taf4.
        (UniProt, P49906 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-36
        Cytogenetic map
        30C7-30C7
        Sequence location
        2L:9,762,424..9,763,262 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        30C7-30C7
        Limits computationally determined from genome sequence between P{lacW}zf30Ck02506&P{EP}undEP424 and P{lacW}l(2)k06416k06416&P{lacW}sopk04603
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        2-36
        (FlyBase, 2016)
        2-31.7
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (16)
        cDNA Clones (6)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          polyclonal
          (Liang et al., 2015, Yokomori et al., 1993)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Additional comments
          Other Comments
          Taf11 is part of the RISC loading complex (RLC). It appears to assemble the RLC by facilitating tetramerisation of Dcr-2-r2d2, enhancing RNAi efficiency.
          (Liang et al., 2015)
          dsRNA has been made from templates generated with primers directed against this gene.
          (Marr et al., 2006)
          The proteins encoded by Tbp, Taf1, Taf2 and Taf11 are likely peripheral subunits of TFIID.
          (Wright et al., 2006)
          Identified with: LP03430 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.
          (BDGP Project Members, 2000-)
          Does not interact, in vitro, with human thryroid-hormone receptor-β.
          (Petty et al., 1996)
          The assembly and purification of various functional Tbp TAF complexes demonstrate that Tbp plus the TAFs is sufficient to replace endogenous TFIID to support activated transcription in vitro.
          (Chen et al., 1994)
          Taf12 and Taf11 join the TfIID complex through interaction with one or more of the larger subunits and only Taf12 may be in contact with Tbp.
          (Yokomori et al., 1993)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 35 )
          Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          InterPro - A database of protein families, domains and functional sites
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Synonyms and Secondary IDs (26)
          Reported As
          Symbol Synonym
          CG4079
          (Fan et al., 2017, Keleman et al., 2009.8.5, Perkins et al., 2009, Aoyagi and Wassarman, 2000)
          G3
          (Liang et al., 2015)
          TAF
          (Müller and Tora, 2004)
          TAF1
          (Pennington et al., 2013)
          TAF11
          (Mussabekova et al., 2017, Liang et al., 2015, Weake et al., 2009, Wright and Tjian, 2009, Marr et al., 2006, Santoso and Kadonaga, 2006, Wright et al., 2006, Tora, 2002)
          TAF30b
          (Hansen et al., 1997)
          TAF30β
          (Green, 2000)
          TAFII
          (Arnosti, 2002)
          TAFII30β
          (Tora, 2002, Wassarman and Sauer, 2001, Adams et al., 2000, Pham et al., 1999, Shen et al., 1998, Tansey and Herr, 1997)
          TAFII30β
          (Kennett et al., 2002)
          TFIID
          (Butler and Kadonaga, 2002, Gu et al., 2002, Hochheimer et al., 2002, Stathopoulos and Levine, 2002, Mizuguchi et al., 2001)
          TFIID 28 beta
          (Nakatani, 1994.2.8)
          TFIID-p28beta
          Taf11
          (Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Liang et al., 2015)
          Taf30β
          (Bell and Tora, 1999, Struhl and Moqtaderi, 1998, Verrijzer et al., 1995, Hori and Carey, 1994, Hoey et al., 1993, Yokomori et al., 1993)
          TafII30β
          (Chen et al., 1994)
          d30β
          (Pugh, 2000)
          dTAFII30
          (Mantovani, 1999, Burke and Kadonaga, 1997, Verrijzer et al., 1994)
          dTAFII30β
          (Wright et al., 2006, Gangloff et al., 2001, Lively et al., 2001, Veenstra and Wolffe, 2001, Cutforth and Gaul, 1999, Zhou et al., 1998, Goodrich and Tjian, 1994)
          dTAFII30
          (Deak et al., 1997)
          dTAFII30 beta
          (Yokomori, 1994.2.25)
          dTAFII30β
          (Saurin et al., 2001)
          taf11
          (Fan et al., 2017)
          Name Synonyms
          TBP-associated factor
          (Schuettengruber et al., 2007)
          TBP-associated factor 11
          TBP-associated factor 30kD subunit β
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (81)