FB2019_05, released Oct 15, 2019

Gene: Dmel\a5

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General Information
Symbol
Dmel\a5
Species
D. melanogaster
Name
antennal protein 5
Annotation Symbol
CG5430
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011294
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
Insufficient genetic data for FlyBase to solicit a summary. [Date last reviewed: 2016-06-30]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
22A1-22A1
Sequence location
2L:1,329,161..1,329,993 [+]
Recombination map
2-3
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the phosphatidylethanolamine-binding protein family. (P54185)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\a5 or the JBrowse view of Dmel\a5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
a5-RA
FBtr0077922
NM_057650
776
210
Additional Transcript Data and Comments
Reported size (kB)
0.687 (longest cDNA)
(Pikielny et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
a5-PA
FBpp0077588
24.6
210
4.53
NP_476998
AAF51385
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
210 (aa)
(Pikielny et al., 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\a5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
defense response to Gram-negative bacterium
inferred from biological aspect of ancestor with PANTHER:PTN002603969
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of antimicrobial humoral response
inferred from biological aspect of ancestor with PANTHER:PTN002603969
(assigned by GO_Central )
(Gaudet et al., 2011)
response to bacterium
inferred from biological aspect of ancestor with PANTHER:PTN002603969
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
third segment of antenna
(Pikielny et al., 1994)
sensillum coeloconicum of antennal segment 3
(Pikielny et al., 1994)
Additional Descriptive Data
a5 transcripts are detected in RNA made from appendages but not head or body. They are restricted to a few scattered sensilla on the posterior surface of the antenna that are probably coeloconic sensilla.
(Pikielny et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\a5 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of a5
Transgenic constructs containing regulatory region of a5
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PEBP1
5 of 15
No
Yes
Hsap\PEBP4
5 of 15
Yes
Yes
Hsap\MRPL38
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Pbp2
5 of 15
Yes
No
Mmus\Pebp4
5 of 15
Yes
Yes
Mmus\Pebp1
4 of 15
No
No
Mmus\Mrpl38
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Pebp1
5 of 13
No
Yes
Rnor\Pbp2
4 of 13
No
No
Rnor\Mrpl38
2 of 13
No
No
Rnor\Pebp4
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\pebp4
4 of 12
Yes
Yes
Xtro\pebp1
3 of 12
No
No
Xtro\LOC100497751
1 of 12
No
No
Xtro\mrpl38
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\pebp1
5 of 15
Yes
No
Drer\mrpl38
1 of 15
No
No
Drer\nudt4b
1 of 15
No
No
Drer\pebp4
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\Y69E1A.5
7 of 15
Yes
Yes
Cele\F40A3.3
5 of 15
No
No
Cele\C56G2.4
1 of 15
No
Yes
Cele\F37C12.10
1 of 15
No
Yes
Cele\mrpl-38
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\E12A11
7 of 9
Yes
No
Atha\FT
7 of 9
Yes
Yes
Atha\TSF
7 of 9
Yes
Yes
Atha\BFT
6 of 9
No
No
Atha\TFL1
6 of 9
No
Yes
Atha\ATC
5 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\TFS1
7 of 15
Yes
No
Scer\YLR179C
7 of 15
Yes
No
Scer\MRPL35
4 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC2F12.10
3 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190F3Y )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\a5
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000736
Drosophila simulans
Dsim\GD23094
Drosophila sechellia
Dsec\GM16814
Drosophila erecta
Dere\GG24786
Drosophila yakuba
Dyak\GE17539
Drosophila ananassae
Dana\GF15180
Drosophila pseudoobscura pseudoobscura
Dpse\GA18875
Drosophila willistoni
Dwil\GK26794
Drosophila virilis
Dvir\GJ17014
Drosophila mojavensis
Dmoj\GI14554
Drosophila grimshawi
Dgri\GH11408
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AI3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012896
Glossina morsitans
Tsetse fly
Gmor\GMOY005343
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07349
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0KH6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_013584gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001716gn
Gallus gallus
Domestic chicken
Ggal\PEBP1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG6180
6 of 10
CG7054
6 of 10
CG10298
6 of 10
CG17917
6 of 10
CG17919
6 of 10
Pebp1
6 of 10
CG30060
5 of 10
mRpL38
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PEBP1; phosphatidylethanolamine binding protein 1
    5 of 15
    604591
        PEBP4; phosphatidylethanolamine binding protein 4
        5 of 15
        612473
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-3
            Cytogenetic map
            22A1-22A1
            Sequence location
            2L:1,329,161..1,329,993 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            22A1-22A1
            Limits computationally determined from genome sequence between P{PZ}l(2)1068510685&P{lacW}Tango14k00619 and P{lacW}RFeSPk11704
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            22A-22B
            (Pikielny, 1994.1.18)
            Experimentally Determined Recombination Data
            Location
            2-3
            (FlyBase, 2016)
            2-2.2
            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (3)
            Genomic Clones (24)
            cDNA Clones (1)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for identity of: a5 CG5430
                    (Li, 1999.11)
                    Source for database merge of
                    Additional comments
                    Other Comments
                    a5 is one of seven clones that have been identified from subtracted cDNA libraries, containing antennal cDNA from which head cDNAs have been subtracted. The protein is expressed in subsets of olfactory hairs and have a putative signal peptide at the amino terminus. a5 protein is highly similar both to vertebrate brain proteins that bind hydrophobic ligands and to yeast and nematode proteins.
                    (Pikielny et al., 1994)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 26 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    Other crossreferences
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyMine - An integrated database for Drosophila genomics
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    Synonyms and Secondary IDs (4)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (33)