l(2)not, l(2)tid, lethal(2)tumorous imaginal discs, tid, lethal(2) tumorous imaginal discs
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
510 (aa); 45 (kD observed); 56 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Alg3 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Alg3 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The mutant phenotype of the "tumorous imaginal discs" (tid) gene was originally described in Kurzik-Dumke et al. 1992 (FBrf0055923), and was subsequently reported to encode a DnaJ-like molecular chap- erone in Kurzik-Dumke et al. 1995 (FBrf0080183). However, the "tid" gene was cloned incorrectly - aberrant cell proliferation in tid mutants arises not from disruptions to the DnaJ homolog (CG5504) but rather to an adjacent gene that encodes the mannosyltransferase Alg3 (CG4084, also called "neighbor of tid", "l(2)not"). To avoid confusion with the previous annotation, the CG4084 gene is referred to as "alg3". FlyBase curator comment: Also to avoid confusion, the "l(2)tid" gene has been renamed back to its CG identifier (CG5504).
In some strains the Alg3, l(2)rot and CG5504 genes are duplicated in tandem (Dp(2;2)KD). This 5327-bp duplication has been found in the Harvich and "a px o" strains, but not in Oregon-R or a "b If" strain.
Mutants display an imaginal disc neoplastic phenotype.