Atr-I, Bab, Atr45A, l(2)k16912, Activin A receptor 45A
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
622, 601 (aa)
babo protein activates TGF-β/Activin response elements, but not BMP response elements, in in vitro assays. Activated babo protein phosphorylates the C-terminal SSXS motif of Smox protein. Med and Smox proteins form some complexes in the absence of activated babo protein, but the level of complex formation increases significantly in the presence of the activated babo protein. Smox protein also interacts transiently with putFBtr0091350:pb-XRbabo protein complexes.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\babo using the Feature Mapper tool.
Isoform-specific expression for three splice variants of babo was demonstrated. One isoform is detected in brain and wing disc, one is detected predominantly in wing disc, and the third isoform is detected in fat body and gut but not brain or wing disc.
The 3.6 and 4.0 kb babo transcripts are found in 0-3 hr embryos, and in adult females.
GBrowse - Visual display of RNA-Seq signalsView Dmel\babo in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.
babo is required for generating the normal number of medulla neuroblasts and laminar precursor cells in the developing optic lobe.
babo is required during the late larval stage for development of adult-specific neurons.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Null mutations and germ line clone analysis demonstrate that babo is not required during embryogenesis but is essential for proper pupation and adult viability. The major defect in mutants is a reduction of cell proliferation within the primordia for adult structures.
Candidate gene for tibia length quantitative trait locus.
Biochemical characterisation of babo, a receptor that binds activin only when coexpressed with type II receptors with which it forms a complex, demonstrates the structural and ligand-binding properties of babo are those of an activin type I receptor. These observations suggest that heteromeric kinase receptor structure is broadly conserved in metazoa.