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Gene Dmel\mtacp1

General Information
Symbol	Dmel\mtacp1	Species	D. melanogaster
Name	mitochondrial acyl carrier protein 1	Annotation symbol	CG9160
Feature type	protein_coding_gene	FlyBase ID	FBgn0011361
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	mtACP
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	61F6-61F6	Sequence location	3L:1,329,806..1,331,633 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial acyl carrier protein 1 is referred to in FlyBase by the symbol Dmel\mtacp1 (CG9160, FBgn0011361). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: acyl carrier activity; phosphopantetheine binding. Based on sequence similarity, it is predicted to be involved in the biological process: mitochondrial electron transport, NADH to ubiquinone; fatty acid biosynthetic process. 10 alleles are reported. The phenotypes of these alleles are annotated with: onion stage spermatid; trichogen cell; spermatid; mesothoracic tergum; trachea; germarium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Acyl carrier protein (ACP); Acyl carrier protein-like; Phosphopantetheine-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, adult testis. Gene sequence location is 3L:1329806..1331633.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27702 HFA08724
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61F6-61F6   Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61F-61F     (Caggese, 1997.7.29) 61F1-61F8     (Caggese, 1996.10.24) 61F6-61F7   (determined by in situ hybridisation)   (Spradling et al., 1999) 61F6-61F8   (determined by in situ hybridisation)   (Ragone et al., 1999) 61F6-61F8   (determined by in situ hybridisation)   (Caggese et al., 1999) 61F6-61F7     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Caggese, 1996.10.24)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mtacp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mtacp1-RA FBtr0072676  NM_057655   885   152 mtacp1-RB FBtr0072677  NM_057654   858   143
Additional Transcript Data & Comments
Reported size (kB)	0.8 (unknown) (Ragone et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mtacp1-PA   FBpp0072569   17.3   152   6.79     NP_477003   AAF47480 mtacp1-PB   FBpp0072570   16.0   143   5.70     NP_477002   AAF47479
Additional Polypeptide Data & Comments
Reported size (kDa)	152, 143 (aa) (Ragone et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphopantetheine-binding (IPR006163) Acyl carrier protein-like (IPR009081) Acyl carrier protein (ACP) (IPR003231) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME09160
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950662   AE014296 AAF47479   AE014296 AAF47480   AC004489   AC005847   AJ000879 CAA04368   AJ000879 CAA04369   AQ026317   AY089404 AAL90142   AY232012   BF487812   BI141922   BI170866   BI216986   BI228711   BI232579   BI234773   BI241173   BI375259   BI564718   BI565068   BI591980   BI609464   BI617267   BI618068   BI618326   BI619960   BI621507   BI624207   BI630920   BP550809   BP556565   BP559399   BP560399   BP560401   BT120138   CO155614   CO156747   CO181109   CO188640   CO195054   CO274412   CO301144   CO326638   CO336672   EC075486   EC195304   EC209447   EC223165   EC260041   EC262175   EC265109   EC265698   EV575938   EV584119   EV590153   EV594083   EV595082   GH759325   GH974565   Y09068 CAA70289   Y09069 CAA70290
UniProtKB/Swiss-Prot	Q94519
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Ragone et al., 1999) embryonic stage 14 -- 17   embryonic/larval dorsal trunk   (Ragone et al., 1999) embryonic/larval tracheal system   (Ragone et al., 1999) embryonic stage 15 -- 17   embryonic/larval lateral trunk   (Ragone et al., 1999) adult stageoogenesis stage S10 -- S11   nurse cell   (Ragone et al., 1999)
Additional Descriptive Data
	Maternally derived mtacp1 transcripts are detected in 0-3hr embryos on northern blots. Zygotic transcripts appear between 6 and 9 hours of embryogenesis and accumulate throughout late embryogenesis. Transcripts decrease in larval stages, increase again in pupae and persist into adulthood. Transcripts are detected by in situ hybridization in the tracheal system. At embryonic stage 14, transcripts are found in the dorsal tracheal trunks. By stage 15, staining is also strong in the lateral tracheal trunks. By stage 16, staining is evident further into the tracheal system. During oogenesis, transcripts are detected at stage S10/11 in nurse cells. Probes specific to each of the two mtacp1 splice variants detect the same pattern of transcription. (Ragone et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011361    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011361 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011361 expression level Developmental Stage   Expression Level embryo 00-02hr    11645 embryo 02-04hr    5158 embryo 04-06hr    4548 embryo 06-08hr    5284 embryo 08-10hr    7171 embryo 10-12hr    14141 embryo 12-14hr    9468 embryo 14-16hr    12053 embryo 16-18hr    13749 embryo 18-20hr    15331 embryo 20-22hr    17318 embryo 22-24hr    15600 larva L1    22085 larva L2    22784 larva L3 12hr old    21001 larva L3 puffstage 1-2    8729 larva L3 puffstage 3-6    5684 larva L3 puffstage 7-9    5569 white prepupae new    5010 white prepupae 12hr    5458 white prepupae 24hr    5387 pupae 2d postWPP    10407 pupae 3d postWPP    24566 pupae 4d postWPP    32609 adult male 01day    24733 adult male 05day    15232 adult male 30day    9399 adult female 01day    24684 adult female 05day    13075 adult female 30day    11802 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11645) embryo 02-04hr  (5158) embryo 04-06hr  (4548) embryo 06-08hr  (5284) embryo 08-10hr  (7171) embryo 10-12hr  (14141) embryo 12-14hr  (9468) embryo 14-16hr  (12053) embryo 16-18hr  (13749) embryo 18-20hr  (15331) embryo 20-22hr  (17318) embryo 22-24hr  (15600) larva L1  (22085) larva L2  (22784) larva L3 12hr old  (21001) larva L3 puffstage 1-2  (8729) larva L3 puffstage 3-6  (5684) larva L3 puffstage 7-9  (5569) white prepupae new  (5010) white prepupae 12hr  (5458) white prepupae 24hr  (5387) pupae 2d postWPP  (10407) pupae 3d postWPP  (24566) pupae 4d postWPP  (32609) adult male 01day  (24733) adult male 05day  (15232) adult male 30day  (9399) adult female 01day  (24684) adult female 05day  (13075) adult female 30day  (11802) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11645) embryo 02-04hr  (5158) embryo 04-06hr  (4548) embryo 06-08hr  (5284) embryo 08-10hr  (7171) embryo 10-12hr  (14141) embryo 12-14hr  (9468) embryo 14-16hr  (12053) embryo 16-18hr  (13749) embryo 18-20hr  (15331) embryo 20-22hr  (17318) embryo 22-24hr  (15600) larva L1  (22085) larva L2  (22784) larva L3 12hr old  (21001) larva L3 puffstage 1-2  (8729) larva L3 puffstage 3-6  (5684) larva L3 puffstage 7-9  (5569) white prepupae new  (5010) white prepupae 12hr  (5458) white prepupae 24hr  (5387) pupae 2d postWPP  (10407) pupae 3d postWPP  (24566) pupae 4d postWPP  (32609) adult male 01day  (24733) adult male 05day  (15232) adult male 30day  (9399) adult female 01day  (24684) adult female 05day  (13075) adult female 30day  (11802) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11645) embryo 02-04hr    5158 embryo 04-06hr    4548 embryo 06-08hr    5284 embryo 08-10hr    7171 embryo 10-12hr  (14141) embryo 12-14hr    9468 embryo 14-16hr  (12053) embryo 16-18hr  (13749) embryo 18-20hr  (15331) embryo 20-22hr  (17318) embryo 22-24hr  (15600) larva L1  (22085) larva L2  (22784) larva L3 12hr old  (21001) larva L3 puffstage 1-2    8729 larva L3 puffstage 3-6    5684 larva L3 puffstage 7-9    5569 white prepupae new    5010 white prepupae 12hr    5458 white prepupae 24hr    5387 pupae 2d postWPP  10407 pupae 3d postWPP  (24566) pupae 4d postWPP  (32609) adult male 01day  (24733) adult male 05day  (15232) adult male 30day    9399 adult female 01day  (24684) adult female 05day  (13075) adult female 30day  (11802) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11645 embryo 02-04hr    5158 embryo 04-06hr    4548 embryo 06-08hr    5284 embryo 08-10hr    7171 embryo 10-12hr    14141 embryo 12-14hr    9468 embryo 14-16hr    12053 embryo 16-18hr    13749 embryo 18-20hr    15331 embryo 20-22hr    17318 embryo 22-24hr    15600 larva L1    22085 larva L2    22784 larva L3 12hr old    21001 larva L3 puffstage 1-2    8729 larva L3 puffstage 3-6    5684 larva L3 puffstage 7-9    5569 white prepupae new    5010 white prepupae 12hr    5458 white prepupae 24hr    5387 pupae 2d postWPP    10407 pupae 3d postWPP    24566 pupae 4d postWPP    32609 adult male 01day    24733 adult male 05day    15232 adult male 30day    9399 adult female 01day    24684 adult female 05day    13075 adult female 30day    11802 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011361 expression level Developmental Stage   Expression Level embryo 00-02hr    11645 embryo 02-04hr    5158 embryo 04-06hr    4548 embryo 06-08hr    5284 embryo 08-10hr    7171 embryo 10-12hr    14141 embryo 12-14hr    9468 embryo 14-16hr    12053 embryo 16-18hr    13749 embryo 18-20hr    15331 embryo 20-22hr    17318 embryo 22-24hr    15600 larva L1    22085 larva L2    22784 larva L3 12hr old    21001 larva L3 puffstage 1-2    8729 larva L3 puffstage 3-6    5684 larva L3 puffstage 7-9    5569 white prepupae new    5010 white prepupae 12hr    5458 white prepupae 24hr    5387 pupae 2d postWPP    10407 pupae 3d postWPP    24566 pupae 4d postWPP    32609 adult male 01day    24733 adult male 05day    15232 adult male 30day    9399 adult female 01day    24684 adult female 05day    13075 adult female 30day    11802 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11645) embryo 02-04hr  (5158) embryo 04-06hr  (4548) embryo 06-08hr  (5284) embryo 08-10hr  (7171) embryo 10-12hr  (14141) embryo 12-14hr  (9468) embryo 14-16hr  (12053) embryo 16-18hr  (13749) embryo 18-20hr  (15331) embryo 20-22hr  (17318) embryo 22-24hr  (15600) larva L1  (22085) larva L2  (22784) larva L3 12hr old  (21001) larva L3 puffstage 1-2  (8729) larva L3 puffstage 3-6  (5684) larva L3 puffstage 7-9  (5569) white prepupae new  (5010) white prepupae 12hr  (5458) white prepupae 24hr  (5387) pupae 2d postWPP  (10407) pupae 3d postWPP  (24566) pupae 4d postWPP  (32609) adult male 01day  (24733) adult male 05day  (15232) adult male 30day  (9399) adult female 01day  (24684) adult female 05day  (13075) adult female 30day  (11802) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11645) embryo 02-04hr  (5158) embryo 04-06hr  (4548) embryo 06-08hr  (5284) embryo 08-10hr  (7171) embryo 10-12hr  (14141) embryo 12-14hr  (9468) embryo 14-16hr  (12053) embryo 16-18hr  (13749) embryo 18-20hr  (15331) embryo 20-22hr  (17318) embryo 22-24hr  (15600) larva L1  (22085) larva L2  (22784) larva L3 12hr old  (21001) larva L3 puffstage 1-2  (8729) larva L3 puffstage 3-6  (5684) larva L3 puffstage 7-9  (5569) white prepupae new  (5010) white prepupae 12hr  (5458) white prepupae 24hr  (5387) pupae 2d postWPP  (10407) pupae 3d postWPP  (24566) pupae 4d postWPP  (32609) adult male 01day  (24733) adult male 05day  (15232) adult male 30day  (9399) adult female 01day  (24684) adult female 05day  (13075) adult female 30day  (11802) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11645 embryo 02-04hr    5158 embryo 04-06hr    4548 embryo 06-08hr    5284 embryo 08-10hr    7171 embryo 10-12hr  14141 embryo 12-14hr    9468 embryo 14-16hr  12053 embryo 16-18hr  13749 embryo 18-20hr  15331 embryo 20-22hr  17318 embryo 22-24hr  15600 larva L1  (22085) larva L2  (22784) larva L3 12hr old  (21001) larva L3 puffstage 1-2    8729 larva L3 puffstage 3-6    5684 larva L3 puffstage 7-9    5569 white prepupae new    5010 white prepupae 12hr    5458 white prepupae 24hr    5387 pupae 2d postWPP  10407 pupae 3d postWPP  (24566) pupae 4d postWPP  (32609) adult male 01day  (24733) adult male 05day  15232 adult male 30day    9399 adult female 01day  (24684) adult female 05day  13075 adult female 30day  11802 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11645 embryo 02-04hr    5158 embryo 04-06hr    4548 embryo 06-08hr    5284 embryo 08-10hr    7171 embryo 10-12hr    14141 embryo 12-14hr    9468 embryo 14-16hr    12053 embryo 16-18hr    13749 embryo 18-20hr    15331 embryo 20-22hr    17318 embryo 22-24hr    15600 larva L1    22085 larva L2    22784 larva L3 12hr old    21001 larva L3 puffstage 1-2    8729 larva L3 puffstage 3-6    5684 larva L3 puffstage 7-9    5569 white prepupae new    5010 white prepupae 12hr    5458 white prepupae 24hr    5387 pupae 2d postWPP    10407 pupae 3d postWPP    24566 pupae 4d postWPP    32609 adult male 01day    24733 adult male 05day    15232 adult male 30day    9399 adult female 01day    24684 adult female 05day    13075 adult female 30day    11802 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011361    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011361 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011361 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9160-RB;CG9160-RA;CG9160-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mtacp1 Stages(s) 1-3 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3L)3C7) mtacp11303 lethal (with Df(3L)bab-PG) mtacp11303 lethal | first instar larval stage | recessive mtacp1920 lethal | larval stage | recessive mtacp11303 lethal | recessive mtacp1j4A6 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 mtacp1GD15185 viable, with Scer\GAL4pnr-MD237 mtacp1GD15398 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mtacp1GD15185 mtacp1GD15398 Phenotype manifest in Allele germarium mtacp1j4A6 mesothoracic tergum, with Scer\GAL4pnr-MD237 mtacp1GD15185 mtacp1GD15398 onion stage spermatid mtacp1j4A6 spermatid mtacp1j4A6 trachea mtacp1j4A6 trichogen cell, with Scer\GAL4pnr-MD237 mtacp1GD15185 mtacp1GD15398
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of mtacp1 Class Mutagen Stocks Known lesion mtacp1j4A6 P-element activity 2 Yes mtacp11303 ethyl methanesulfonate 1 -- mtacp1CB-5593-3 1 -- mtacp1920 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mtacp1 Class Mutagen Stocks Known lesion mtacp1GD15185 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mtacp1GD15398 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mtacp1HM05206 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtacp1KK107702 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtacp1t5.7 in vitro construct - genomic fragment 0 Yes mtacp1Ubi.PH 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Ar14-8 (Spradling et al., 1999) Df(3L)bab-PG (Spradling et al., 1999) Df(3L)BSC250 (Gresens et al., 2007.3.22)
Partially disrupted in	Df(3L)920 (Hegan et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15185} NA P{GD15398} NA P{KK107702} NA P{TRiP.HM05206} NA characterization construct P{Myo61F+t5.7} NA P{Ubi-mtacp1.H} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}mtacp1CB-5593-3 NA insertion of enhancer trap P{lacW}mtacp1j4A6 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
acyl carrier activity inferred from electronic annotation with InterPro:IPR009081 (FlyBase Curators et al., 2004-) inferred from sequence alignment with UniProtKB:P52505 (Ragone et al., 1999) cofactor binding inferred from electronic annotation with InterPro:IPR006163 (FlyBase Curators et al., 2004-) phosphopantetheine binding inferred from sequence alignment with UniProtKB:P52505 (Ragone et al., 1999)
Biological Process
CV term Evidence References
fatty acid biosynthetic process inferred from electronic annotation with InterPro:IPR003231 (FlyBase Curators et al., 2004-) inferred from sequence alignment with UniProtKB:P52505 (Ragone et al., 1999) mitochondrial electron transport, NADH to ubiquinone inferred from sequence alignment with UniProtKB:P52505 (Ragone et al., 1999)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence alignment with UniProtKB:P52505 (Ragone et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mtacp1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63697 DroID - A comprehensive database of gene and protein interactions. • FBgn0011361 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38154
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24455 Dere\GG14782 Dgri\GH15216 Dmoj\GI11927 Dper\GL16180 Dpse\GA21583 Dsec\GM14402 Dsim\GD13611 Dvir\GJ12150 Dwil\GK13357 Dyak\mtacp1
Curated drosophilid orthologs	Dpse\GA21583 (Tripoli et al., 2005) Dyak\mtacp1
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010611-PA Aedes aegypti (mosquito) AAEL011689-PA Aedes aegypti (mosquito) AGAP010464-PA Anopheles gambiae (mosquito) XP_623253.1 Apis mellifera (honey bee) XP_001951141.1 Acyrthosiphon pisum (pea aphid) At2g44620.1 Arabidopsis thaliana (wall cress) 14822 Batrachochytrium dendrobatidis (chytrid fungus) 200544 Branchiostoma floridae (lancelet) 227439 Branchiostoma floridae (lancelet) XP_001895265.1 Brugia malayi (roundworm nematode) ENSBTAP00000008382 Bos taurus (bovine) CAL0001529 Candida albicans (a form of yeast) CN22965 Caenorhabditis brenneri (small nematode) CBP03261 Caenorhabditis briggsae (nematode) CE22587 Caenorhabditis elegans (worm) ENSCAFP00000025950 Canis familiaris (dog) CAGL0J04664g Candida glabrata (haploid yeast) JA09971 Caenorhabditis japonica (nematode) CMS372C Cyanidioschyzon merolae (red alga) cn04194 Cryptococcus neoformans (yeast-like fungus) CPIJ006168 Culex pipens (mosquito) ENSCPOP00000010829 Cavia porcellus (guinea pig) RP18781 Caenorhabditis remanei (nematode) ENSCSAVP00000019640 Ciona savignyi (sedentary tunicate) 155954 Capitella spl (polychaete worm) DDB0238774 Dictyostelium discoideum (amoeba) DEHA2C08470g Debaryomyces Hansenii (yeast) ENSDARP00000012558 Danio rerio (zebra fish) ENSECAP00000008698 Equus caballus (horse) ENSGACP00000018909 Gymnopilus aculeatus (mushroom) ENSGALP00000009787 Gallus gallus (chicken) 86883 Hypsipyla robusta (cedar shoot borer) ENSP00000007516 Homo sapiens (human) KLLA0D02838g Kluyveromyces lactis (yeast) 110237 Lottia gigantea (owl limpet) LmjF27.0290 Leishmania major (virus) ENSMODP00000020437 Monodelphis domestica (gray opossum) ENSMMUP00000027028 Macaca mulatta (rhesus monkey) ENSMUSP00000033157 Mus musculus (house mouse) 236403 Nematostella vectensis (starlet anemone) XP_001599197.1 Nasonia vitripennis (wasp) ENSOANP00000012212 Ornithorynchus anatinus (platypus) ENSORLP00000016034 Oryzias latipes (japanese killifish) LOC_Os03g22950.1 Oryza sativa (asian rice) LOC_Os07g12150.1 Oryza sativa (asian rice) PFB0385w Plasmodium falciparum (protozoal parasite) PP09873 Pristionchus pacificus (nematode) 104574 Physcomitrella patens (moss) ENSPPYP00000008133 Pongo pygmaeus (orangutan) 94082 Phytophthora ramorum (sudden oak death pathogen) 158374 Phytophthora sojae (root rot pathogen) 824957 Populus trichocarpa (black cottonwood) ENSPTRP00000013471 Pan troglodytes (chimpanzee) ENSRNOP00000024471 Rattus norvegicus (norway rat) 4789562 Sorghum bicolor (sorghum) YKL192C Saccharomyces cerevisiae (budding yeast) Smp_015860 Schistosoma mansoni (trematode parasite) SPAC4H3.09 Schizosaccharomyces pombe (fission yeast) 35520 Trichoplax adhaerens (metazoa) XP_967013.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014566 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024645 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052831 Xenopus tropicalis (frog) YALI0D24629g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17905 NV18155 LH19552 FBgn0067944 FBgn0215366 FBgn0199402 FBgn0185321 FBgn0169327 FBgn0081569 FBgn0153784 FBgn0134685 FBgn0122691 FBgn0107038 FBgn0101449 BGIBMGA009845 ACYPI007688 ACYPI000543 GB15102 AGAP010464 AAEL011689 AAEL010611 PHUM011780 GLEAN_05501
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	29528 y1 v1; P{TRiP.HM05206}attP2 7291 mtacp11303 vn1 st1/TM6B, Tb1 12061 y1 w*; P{lacW}mtacp1j4A6/TM6B, Tb+
Kyoto	123701 w1118; P{RS3}mtacp1CB-5593-3 111378 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}mtacp1j4A6 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
VDRC	v107907 P{KK107702}VIE-260B v39232 w1118; P{GD15398}v39232 v43502 w1118; P{GD15185}v43502 v43503 w1118; P{GD15185}v43503 v39233 w1118; P{GD15398}v39233/TM3
Genomic Clones ( 1 )
	BACR17K17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 52 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT22870 RE40155
Other clones	yak-ad_mtacp1
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD30582 RE12467 RE24493 RE26340 RE28668 RE30529 RE38190 RE63020 RH09558 RH14249 RH47541 RH48592 RH48947 RH51107 RH52859 RH60264 RH62216 RH62728 RH63728 SD15894
Other clones	12641 57934 77449 214449.19 525051 528197 558106 CK01.49D.G3 Dmel_dig_010313_0707_1640 Dmel_dig_016534_0671_3036 Dmel_neb_008268_0578_1355 Dmel_neb_008847_0446_1975 Dmel_neb_014646_0608_1530 EC13554 EC39640 EK041326 EK114037 EK180233 EN06426 EN09029 EN13015 EP04348 FGM209C06 FGM304C05 FGM320F11 FGX002B02 FGX002B04 RP003391594 RP004360815
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011361 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38154
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mtacp1 l(3)j4A6 (Ragone et al., 1999)
Additional comments
Other Comments
	mtacp1 is essential for viability and is required for both male and female gametogenesis. (Ragone et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057654 NM_057655 RefSeq (Proteins) • NP_477002 NP_477003 DDBJ / EMBL / GenBank • AAF47479 AAF47480 AAL90142 AC004489 AC005847 AJ000879 AQ026317 AY089404 BF487812 CAA04368 CAA04369 CAA70289 CAA70290 Y09068 Y09069 Entrez Gene - A searchable database of RefSeq genes. • 38154 UniProtKB/Swiss-Prot • Q94519
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphopantetheine-binding (IPR006163) Acyl carrier protein-like (IPR009081) Acyl carrier protein (ACP) (IPR003231) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME09160
Linkouts
	BioGRID - A database of protein and genetic interactions • 63697 DroID - A comprehensive database of gene and protein interactions. • FBgn0011361 DRSC - Results from RNAi screens. • FBgn0011361 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011361 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9160-RB;CG9160-RA;CG9160-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011361 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38154 InParanoid A subset of ortholog calls from InParanoid. • AAEL010611-PA Aedes aegypti (mosquito) AAEL011689-PA Aedes aegypti (mosquito) AGAP010464-PA Anopheles gambiae (mosquito) XP_623253.1 Apis mellifera (honey bee) XP_001951141.1 Acyrthosiphon pisum (pea aphid) At2g44620.1 Arabidopsis thaliana (wall cress) 14822 Batrachochytrium dendrobatidis (chytrid fungus) 200544 Branchiostoma floridae (lancelet) 227439 Branchiostoma floridae (lancelet) XP_001895265.1 Brugia malayi (roundworm nematode) ENSBTAP00000008382 Bos taurus (bovine) CAL0001529 Candida albicans (a form of yeast) CN22965 Caenorhabditis brenneri (small nematode) CBP03261 Caenorhabditis briggsae (nematode) CE22587 Caenorhabditis elegans (worm) ENSCAFP00000025950 Canis familiaris (dog) CAGL0J04664g Candida glabrata (haploid yeast) JA09971 Caenorhabditis japonica (nematode) CMS372C Cyanidioschyzon merolae (red alga) cn04194 Cryptococcus neoformans (yeast-like fungus) CPIJ006168 Culex pipens (mosquito) ENSCPOP00000010829 Cavia porcellus (guinea pig) RP18781 Caenorhabditis remanei (nematode) ENSCSAVP00000019640 Ciona savignyi (sedentary tunicate) 155954 Capitella spl (polychaete worm) DDB0238774 Dictyostelium discoideum (amoeba) DEHA2C08470g Debaryomyces Hansenii (yeast) ENSDARP00000012558 Danio rerio (zebra fish) ENSECAP00000008698 Equus caballus (horse) ENSGACP00000018909 Gymnopilus aculeatus (mushroom) ENSGALP00000009787 Gallus gallus (chicken) 86883 Hypsipyla robusta (cedar shoot borer) ENSP00000007516 Homo sapiens (human) KLLA0D02838g Kluyveromyces lactis (yeast) 110237 Lottia gigantea (owl limpet) LmjF27.0290 Leishmania major (virus) ENSMODP00000020437 Monodelphis domestica (gray opossum) ENSMMUP00000027028 Macaca mulatta (rhesus monkey) ENSMUSP00000033157 Mus musculus (house mouse) 236403 Nematostella vectensis (starlet anemone) XP_001599197.1 Nasonia vitripennis (wasp) ENSOANP00000012212 Ornithorynchus anatinus (platypus) ENSORLP00000016034 Oryzias latipes (japanese killifish) LOC_Os03g22950.1 Oryza sativa (asian rice) LOC_Os07g12150.1 Oryza sativa (asian rice) PFB0385w Plasmodium falciparum (protozoal parasite) PP09873 Pristionchus pacificus (nematode) 104574 Physcomitrella patens (moss) ENSPPYP00000008133 Pongo pygmaeus (orangutan) 94082 Phytophthora ramorum (sudden oak death pathogen) 158374 Phytophthora sojae (root rot pathogen) 824957 Populus trichocarpa (black cottonwood) ENSPTRP00000013471 Pan troglodytes (chimpanzee) ENSRNOP00000024471 Rattus norvegicus (norway rat) 4789562 Sorghum bicolor (sorghum) YKL192C Saccharomyces cerevisiae (budding yeast) Smp_015860 Schistosoma mansoni (trematode parasite) SPAC4H3.09 Schizosaccharomyces pombe (fission yeast) 35520 Trichoplax adhaerens (metazoa) XP_967013.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014566 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024645 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052831 Xenopus tropicalis (frog) YALI0D24629g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38154 modMine - Data generated by the modENCODE project. • FBgn0011361 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17905 NV18155 LH19552 FBgn0067944 FBgn0215366 FBgn0199402 FBgn0185321 FBgn0169327 FBgn0081569 FBgn0153784 FBgn0134685 FBgn0122691 FBgn0107038 FBgn0101449 BGIBMGA009845 ACYPI007688 ACYPI000543 GB15102 AGAP010464 AAEL011689 AAEL010611 PHUM011780 GLEAN_05501
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG9160 (Porcelli et al., 2007, Tripoli et al., 2005, Qin et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Tiefenböck et al., 2010, Cammarato et al., 2011) l(3)1303 (Wei et al., 2003) l(3)j4A6   mtACP (Caggese, 1997.7.29, Xu et al., 2006, Tripoli et al., 2005) mtacp1 (Gresens et al., 2007.3.22, Xu et al., 2006, Dorus et al., 2006, Porcelli et al., 2007, Tripoli et al., 2005, Hegan et al., 2007, Qin et al., 2005, Liu and Lehmann, 2008, Raker et al., 2009, Dorus et al., 2006, Pospisilik et al., 2010, Wasbrough et al., 2010) mtACP1 (Tripoli et al., 2005, Tiefenböck et al., 2010) ND-AcC (Spradling et al., 1999, )
Name Synonym	mitochondrial acyl carrier protein 1 (Ragone et al., 1999, Wasbrough et al., 2010, Cammarato et al., 2011) Mitochondrial acyl carrier protein 1 (Qin et al., 2005) NADH:ubiquinone oxidoreductase Acyl carrier (Tripoli et al., 2005) NADH ubiquinone oxidoreductase ACP (Porcelli et al., 2007) NADH-ubiquinone oxidoreductase acyl carrier protein (Porcelli et al., 2007, Tripoli et al., 2005) NADH ubiquinone oxidoreductase acyl carrier protein (Tripoli et al., 2005) NADH-ubiquinone oxidoreductase acyl-carrier subunit (Caggese, 1996.10.24, Caggese, 1996.10.24, )
Secondary FlyBase IDs
	FBgn0017568
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Tiefenböck et al., 2010, EMBO J. 29(1): 171--183 The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. [FBrf0209639] Wasbrough et al., 2010, J. Proteomics 73(11): 2171--2185 The Drosophila melanogaster sperm proteome-II (DmSP-II). [FBrf0211978] Show all research papers ...