l(3)neo41, Set8, Set7
Set domain protein - methyltransferase that targets Histone H4 - helps maintain silent chromatin by a histone modification that precludes neighboring acetylation of the H4 tail
Please see the JBrowse view of Dmel\PR-Set7 for information on other features
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Gene model reviewed during 5.41
Gene model reviewed during 5.53
Low-frequency RNA-Seq exon junction(s) not annotated.
The group(s) of polypeptides indicated below share identical sequence to each other.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PR-Set7 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
GBrowse - Visual display of RNA-Seq signals
View Dmel\PR-Set7 in GBrowse 23-55
3-55
3-53.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: pr-set7 CG3307
Source for identity of: pr-set7 l(3)neo41
Source for identity of: Set8 pr-set7
Source for identity of: PR-Set7 CG3307
Monomethylated H4K20 is strongly reduced in pr-set7 mutant larval brains.
Double-stranded breaks are not increased in pr-set7 mutants.
The DNA damage checkpoint, especially the ATR is pathway, is activated in pr-set7 mutants.
The DNA repair pathway is activated after γ-irradiation in pr-set7 mutants.
pr-set7 mutations suppress position effect variegation.
A mutation in pr-set7 decreases levels of H4-K20 methylation in vivo and causes lethality.
Disruption of pr-set7 results in lethality.
A. Spradling.