FB2019_06, released Dec 19, 2019

Gene: Dmel\PR-Set7

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General Information
Symbol
Dmel\PR-Set7
Species
D. melanogaster
Name
PR/SET domain containing protein 7
Annotation Symbol
CG3307
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011474
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
PR/SET domain containing protein 7 (PR-Set7) encodes the histone methyltransferase that controls lysine20 monomethylation of the product of His4. This histone mark is essential for normal progression through the cell cycle. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
l(3)neo41, Set8, Set7
Key Links
Genomic Location
Cytogenetic map
88B3-88B3
Sequence location
3R:14,316,038..14,320,494 [+]
Recombination map
3-55
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily. (Q9VFK6)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
histone methyltransferase activity (H4-K20 specific)
Predictions / Assertions
histone methyltransferase activity (H4-K20 specific)
Summaries
Gene Group (FlyBase)
SET DOMAIN LYSINE METHYLTRANSFERASES -
SET domain lysine methyltransferases (KMTs) catalyze the addition of methyl groups to lysine residues. SET domain KMTs possess a domain that was original characterized in the D.mel KMTs Su(var)3-9, E(z) and trx. (Adapted from FBrf0216343).
Protein Function (UniProtKB)
Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis.
(UniProt, Q9VFK6)
Summary (Interactive Fly)
Set domain protein - methyltransferase that targets Histone H4 - helps maintain silent chromatin by a histone modification that precludes neighboring acetylation of the H4 tail
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\PR-Set7 or the JBrowse view of Dmel\PR-Set7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.41
Gene model reviewed during 5.53
Low-frequency RNA-Seq exon junction(s) not annotated.
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
PR-Set7-RA
FBtr0082929
NM_142097
3311
691
PR-Set7-RB
FBtr0082930
NM_169577
4183
691
PR-Set7-RD
FBtr0309996
NM_001260171
3175
691
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
PR-Set7-PA
FBpp0082388
76.5
691
7.40
NP_650354
AAF55047
PR-Set7-PB
FBpp0082389
76.5
691
7.40
NP_731900
AAN13605
PR-Set7-PD
FBpp0301702
76.5
691
7.40
NP_001247100
AFH06418
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

691 aa isoforms: PR-Set7-PA, PR-Set7-PB, PR-Set7-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PR-Set7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
histone methyltransferase activity (H4-K20 specific)
inferred from mutant phenotype
(Yang et al., 2008, Karachentsev et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
histone methyltransferase activity (H4-K20 specific)
traceable author statement
(Simms et al., 2003, Zhimulev and Belyaeva, 2003)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
chromosome condensation
inferred from direct assay
(Sakaguchi and Steward, 2007)
inferred from genetic interaction with FLYBASE:mei-41; FB:FBgn0004367
(Sakaguchi and Steward, 2007)
DNA damage checkpoint
inferred from direct assay
(Sakaguchi and Steward, 2007)
histone H4-K20 monomethylation
inferred from mutant phenotype
(Yang et al., 2008)
histone methylation
inferred from mutant phenotype
(Karachentsev et al., 2005, Fang et al., 2002, Nishioka et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
histone methylation
traceable author statement
(Simms et al., 2003)
negative regulation of histone acetylation
traceable author statement
(Simms et al., 2003)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
polytene chromosome
inferred from direct assay
(Karachentsev et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
polytene chromosome
inferred from direct assay
(Karachentsev et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\PR-Set7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of PR-Set7
Transgenic constructs containing regulatory region of PR-Set7
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage (with Df(3R)red3l)
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
flightless, with Scer\GAL4Mef2.PR
mitotic cell cycle defective
neuroanatomy defective
neuroanatomy defective (with Df(3R)red3l)
non-enhancer of variegation, with P{hsp26-pt-T}39C-27
non-enhancer of variegation, with P{hsp26-pt-T}39C-31
non-enhancer of variegation, with P{hsp26-pt-T}39C-50
non-enhancer of variegation, with P{hsp26-pt-T}39C-55
non-enhancer of variegation, with P{hsp26-pt-T}39C-62
non-suppressor of variegation, with P{hsp26-pt-T}39C-27
non-suppressor of variegation, with P{hsp26-pt-T}39C-31
non-suppressor of variegation, with P{hsp26-pt-T}39C-50
non-suppressor of variegation, with P{hsp26-pt-T}39C-55
non-suppressor of variegation, with P{hsp26-pt-T}39C-62
some die during larval stage (with Df(3R)red3l)
some die during larval stage | recessive
some die during pupal stage | recessive
suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10
suppressor of variegation | dominant, with P{hsp26-pt-T}Dyrk3118E-15
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
chromosome
condensed chromosome
embryonic/larval brain | third instar larval stage
embryonic/larval brain | third instar larval stage (with Df(3R)red3l)
embryonic/larval cuticle
embryonic/larval cuticle (with Df(3R)red3l)
embryonic/larval digestive system (with Df(3R)red3l)
embryonic/larval tracheal system
eye (with Df(3R)red3l)
eye (with PR-Set71)
eye (with PR-Set720)
macrochaeta (with Df(3R)red3l)
melanotic mass
melanotic mass (with Df(3R)red3l)
mesothoracic tergum, with Scer\GAL4pnr-MD237
myofibril, with Scer\GAL4Mef2.PR
neuroblast | third instar larval stage
sarcomere, with Scer\GAL4Mef2.PR
ventral thoracic disc
wing disc
wing margin (with Df(3R)red3l)
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KMT5A
10 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kmt5a
9 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Kmt5a
6 of 13
Yes
Yes
Rnor\RGD1561318
3 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\kmt5a
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (4)
Drer\kmt5aa
8 of 15
Yes
Yes
Drer\kmt5ab
8 of 15
Yes
Yes
Drer\avpr2aa
1 of 15
No
Yes
Drer\si:dkey-23a23.2
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\set-1
7 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\set1
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908CP )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\PR-Set7
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009622
Drosophila simulans
Dsim\GD18956
Drosophila sechellia
Dsec\GM24161
Drosophila erecta
Dere\GG16850
Drosophila yakuba
Dyak\GE24231
Drosophila ananassae
Dana\GF17507
Drosophila pseudoobscura pseudoobscura
Dpse\GA17259
Drosophila persimilis
Dper\GL23503
Drosophila willistoni
Dwil\GK10941
Drosophila virilis
Dvir\GJ22807
Drosophila mojavensis
Dmoj\GI22805
Drosophila grimshawi
Dgri\GH17478
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508X4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021497
Glossina morsitans
Tsetse fly
Gmor\GMOY005450
Mayetiola destructor
Hessian fly
Mdes\Mdes008970
Mayetiola destructor
Hessian fly
Mdes\Mdes008973
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000193
Anopheles darlingi
American malaria mosquito
Adar\ADAC006491
Anopheles gambiae
Malaria mosquito
Agam\AGAP012481
Anopheles gambiae
Malaria mosquito
Agam\AGAP012610
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000732
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0E33 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012853
Danaus plexippus
Monarch butterfly
Dple\DPOGS206896-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006860
Apis florea
Little honeybee
Aflo\3331350196
Apis mellifera
Western honey bee
Amel\GB41135
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23742
Bombus terrestris
Buff-tailed bumblebee
Bter\15207241
Linepithema humile
Argentine ant
Lhum\LH18657
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0013df
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003825
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003824
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11484
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11488
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15766
Pediculus humanus
Human body louse
Phum\PHUM315980
Rhodnius prolixus
Kissing bug
Rpro\RPRC006378
Cimex lectularius
Bed bug
Clec\CLEC003862
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002722
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05607
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0E1H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009170
Ixodes scapularis
Black-legged tick
Isca\ISCW020034
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72722.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g02380
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g02320
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311914
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0UBI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Setd8
Ciona intestinalis
Vase tunicate
Cint\LOC100176062
Gallus gallus
Domestic chicken
Ggal\SETD8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KMT5A; lysine methyltransferase 5A
    10 of 15
    607240
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        PR-Set7
        suppressible
        mei-41
        (Sakaguchi and Steward, 2007)
        PR-Set7
        enhanceable
        mei-41
        (Sakaguchi and Steward, 2007)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-55
        Cytogenetic map
        88B3-88B3
        Sequence location
        3R:14,316,038..14,320,494 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        88B3-88B3
        Limits computationally determined from genome sequence between P{lacW}trxj14A6&P{PZ}trx00347 and P{PZ}cv-c06951
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        88C1-88C10
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        88C1-88C10
        (BDGP Project Members, 1994-1999)
        88C-88C
        (determined by in situ hybridisation)
        (Cooley et al., 1988)
        Experimentally Determined Recombination Data
        Location
        3-55
        (FlyBase, 2016)
        3-53.1
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (18)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (59)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: pr-set7 CG3307
          (Fang et al., 2002)
          Source for identity of: pr-set7 l(3)neo41
          (Ketel, 2003.2.10)
          Source for identity of: Set8 pr-set7
          (FlyBase, 2009-)
          Source for identity of: PR-Set7 CG3307
          (Nishioka et al., 2002)
          Source for database merge of
          Additional comments
          Other Comments
          Monomethylated H4K20 is strongly reduced in pr-set7 mutant larval brains.
          (Sakaguchi and Steward, 2007)
          Double-stranded breaks are not increased in pr-set7 mutants.
          (Sakaguchi and Steward, 2007)
          The DNA damage checkpoint, especially the ATR is pathway, is activated in pr-set7 mutants.
          (Sakaguchi and Steward, 2007)
          The DNA repair pathway is activated after γ-irradiation in pr-set7 mutants.
          (Sakaguchi and Steward, 2007)
          pr-set7 mutations suppress position effect variegation.
          (Karachentsev et al., 2005)
          A mutation in pr-set7 decreases levels of H4-K20 methylation in vivo and causes lethality.
          (Ketel et al., 2003)
          Disruption of pr-set7 reduces levels of His4 K20 methylation.
          (Fang et al., 2002)
          Disruption of pr-set7 results in lethality.
          (Fang et al., 2002)
          Origin and Etymology
          Discoverer
          A. Spradling.
          Etymology
          Identification
          External Crossreferences and Linkouts ( 45 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (19)
          Datasets (1)
          Study focus (1)
          Experimental Role
          Project
          Project Type
          Title
          • bait_protein
          modENCODE_chromatin_proteins_cells
          Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
          References (75)