• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\pr-set7

General Information
Symbol	Dmel\pr-set7	Species	D. melanogaster
Name	pr-set7	Annotation symbol	CG3307
Feature type	protein_coding_gene	FlyBase ID	FBgn0011474
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	l(3)neo41, Set8, Set7, dSET8
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88B3-88B3	Sequence location	3R:10,141,710..10,146,216 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pr-set7 is referred to in FlyBase by the symbol Dmel\pr-set7 (CG3307, FBgn0011474). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone methyltransferase activity (H4-K20 specific). There is experimental evidence that it is involved in the biological process: histone methylation; chromosome condensation; histone H4-K20 monomethylation; DNA damage checkpoint. 6 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; thoracic segment; multicellular structure; adult segment; larval thorax; adult mesothoracic segment; imaginal precursor; embryonic/larval tracheal system; organelle; sensillum; dorsal thoracic disc; external compound sense organ. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: SET domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1624463_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of pr-set7. Gene sequence location is 3R:10141710..10146216.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN21718 HFA15473
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88B3-88B3   Limits computationally determined from genome sequence between P{lacW}trxj14A6&P{PZ}trx00347 and P{PZ}cv-c06951
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88C1-88C10   (determined by in situ hybridisation)   (Spradling et al., 1999) 88C1-88C10     (BDGP Project Members, 1994-1999) 88C-88C   (determined by in situ hybridisation)   (Cooley et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pr-set7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pr-set7-RA FBtr0082929  NM_142097   3306   691 pr-set7-RB FBtr0082930  NM_169577   4178   691 pr-set7-RC FBtr0082928  NM_169578   3184   691 pr-set7-RD FBtr0309996     3208   691
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pr-set7-PA   FBpp0082388   76.5   691   7.40     NP_650354   AAF55047 pr-set7-PB   FBpp0082389   76.5   691   7.40     NP_731900   AAN13605 pr-set7-PC   FBpp0082387   76.5   691   7.40     NP_731901   AAN13606 pr-set7-PD   FBpp0301702   76.5   691   7.40
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SET domain (IPR001214)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392887   AA536561   AA540109   AA694749   AA952046   AA979081   AE014297 AAF55047   AE014297 AAN13605   AE014297 AAN13606   AQ026345   AW942217   AY102673 AAM27502   AY283060 AAP35083   BF486988   BF487027   BF501641   BG633539   BI167914   BI173412   BI232215   BI235017   BI236216   BI243871   BI357108   BI362444   BI365661   BI482855   BI483793   BI579229   BI579251   BI579264   BI579356   BI641197   BP541956   CO182617   CO185143   CO188112   CO267100   CO272089   CO273367   CO278041   CO280008   CO280401   CO282790   CO284072   CO286519   CO288838   CO290066   CO293979   CO294519   CO297775   CO299755   CO300374   CO307717   CO312760   CO315213   CO316089   CO317849   CO320703   CO333284   CO333832   CO340547   CO343619   EC057562   EC067986   EC070197   EC070301   EC071940   EC085201   EC085395   EC202508   EC203133   EC203960   EC206732   EC209209   EC210311   EC210632   EC212722   EC218048   EC222514   EC224360   EC225964   EC227149   EC238543   EC245213   EC246018   EC249126   EC250579   EC252448   EC257213   EC259283   EV575812   EV600633   GH942134   GH943961   GH965430   GH975169
UniProtKB/Swiss-Prot	Q9VFK6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011474    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011474 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011474 expression level Developmental Stage   Expression Level embryo 00-02hr    3825 embryo 02-04hr    3311 embryo 04-06hr    5295 embryo 06-08hr    4361 embryo 08-10hr    2941 embryo 10-12hr    1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day    2365 adult female 30day    2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3825) embryo 02-04hr  (3311) embryo 04-06hr  (5295) embryo 06-08hr  (4361) embryo 08-10hr  (2941) embryo 10-12hr  (1503) embryo 12-14hr  (1378) embryo 14-16hr  (754) embryo 16-18hr  (681) embryo 18-20hr  (476) embryo 20-22hr  (472) embryo 22-24hr  (508) larva L1  (510) larva L2  (493) larva L3 12hr old  (330) larva L3 puffstage 1-2  (273) larva L3 puffstage 3-6  (666) larva L3 puffstage 7-9  (845) white prepupae new  (1078) white prepupae 12hr  (1078) white prepupae 24hr  (1162) pupae 2d postWPP  (754) pupae 3d postWPP  (417) pupae 4d postWPP  (486) adult male 01day  (479) adult male 05day  (400) adult male 30day  (341) adult female 01day  (1049) adult female 05day  (2365) adult female 30day  (2270) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3825) embryo 02-04hr  (3311) embryo 04-06hr  (5295) embryo 06-08hr  (4361) embryo 08-10hr  (2941) embryo 10-12hr  1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day  (2365) adult female 30day  (2270) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3825 embryo 02-04hr    3311 embryo 04-06hr    5295 embryo 06-08hr    4361 embryo 08-10hr    2941 embryo 10-12hr    1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day    2365 adult female 30day    2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3825 embryo 02-04hr    3311 embryo 04-06hr    5295 embryo 06-08hr    4361 embryo 08-10hr    2941 embryo 10-12hr    1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day    2365 adult female 30day    2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011474 expression level Developmental Stage   Expression Level embryo 00-02hr    3825 embryo 02-04hr    3311 embryo 04-06hr    5295 embryo 06-08hr    4361 embryo 08-10hr    2941 embryo 10-12hr    1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day    2365 adult female 30day    2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3825) embryo 02-04hr  (3311) embryo 04-06hr  (5295) embryo 06-08hr  (4361) embryo 08-10hr  (2941) embryo 10-12hr  (1503) embryo 12-14hr  (1378) embryo 14-16hr  (754) embryo 16-18hr  (681) embryo 18-20hr  (476) embryo 20-22hr  (472) embryo 22-24hr  (508) larva L1  (510) larva L2  (493) larva L3 12hr old  (330) larva L3 puffstage 1-2  (273) larva L3 puffstage 3-6  (666) larva L3 puffstage 7-9  (845) white prepupae new  (1078) white prepupae 12hr  (1078) white prepupae 24hr  (1162) pupae 2d postWPP  (754) pupae 3d postWPP  (417) pupae 4d postWPP  (486) adult male 01day  (479) adult male 05day  (400) adult male 30day  (341) adult female 01day  (1049) adult female 05day  (2365) adult female 30day  (2270) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3825) embryo 02-04hr  (3311) embryo 04-06hr  (5295) embryo 06-08hr  (4361) embryo 08-10hr  (2941) embryo 10-12hr  1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day  2365 adult female 30day  2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3825 embryo 02-04hr    3311 embryo 04-06hr    5295 embryo 06-08hr    4361 embryo 08-10hr    2941 embryo 10-12hr    1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day    2365 adult female 30day    2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3825 embryo 02-04hr    3311 embryo 04-06hr    5295 embryo 06-08hr    4361 embryo 08-10hr    2941 embryo 10-12hr    1503 embryo 12-14hr    1378 embryo 14-16hr    754 embryo 16-18hr    681 embryo 18-20hr    476 embryo 20-22hr    472 embryo 22-24hr    508 larva L1    510 larva L2    493 larva L3 12hr old    330 larva L3 puffstage 1-2    273 larva L3 puffstage 3-6    666 larva L3 puffstage 7-9    845 white prepupae new    1078 white prepupae 12hr    1078 white prepupae 24hr    1162 pupae 2d postWPP    754 pupae 3d postWPP    417 pupae 4d postWPP    486 adult male 01day    479 adult male 05day    400 adult male 30day    341 adult female 01day    1049 adult female 05day    2365 adult female 30day    2270 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011474    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011474 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011474 expression level Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011474 expression level Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    130.225 Larval Midgut    40.2 Larval Hindgut    51.6 Larval Malpighian Tubules    23 Larval Fat Body    24.2 Larval Salivary Gland    79.9 Larval Trachea    45.175 Larval Carcass    35.85 Adult Head    32 Adult Eye    30.55 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    71 Adult Crop    24.6 Adult Midgut    22.5 Adult Hindgut    33.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.5 Adult Salivary Gland    47.8 Adult Heart    20.075 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    236.2 Adult Testis    19.5 Adult Male Accessory Gland    34.5 Adult Carcass    42.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    32   NA  Eye    30.55   NA  Brain    76.5   130.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    71   NA  Crop    24.6   40.2  Midgut    22.5   51.6  Hindgut    33.1   23  Malpighian Tubules    no informative data   24.2  Fat Body    37.5   79.9  Salivary Gland    47.8   NA  Heart    20.075   45.175  Trachea    NA   NA  VirginFemale Spermatheca    8.7   NA  InseminatedFemale Spermatheca    6   NA  Ovary    236.2   NA  Testis    19.5   NA  Male Accessory Gland    34.5   35.85  Carcass    42.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011474 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3307-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for pr-set7 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage (with Df(3R)red3l) pr-set720 lethal | larval stage | recessive pr-set71 pr-set720 lethal | pupal stage | recessive pr-set7EY04668 lethal | recessive pr-set71 viable, with Scer\GAL4pnr-MD237 pr-set7GD10930 Other Phenotypes Allele mitotic cell cycle defective pr-set720 neuroanatomy defective pr-set720 neuroanatomy defective (with Df(3R)red3l) pr-set720 non-enhancer of variegation, with P{hsp26-pt-T}39C-27 pr-set720 non-enhancer of variegation, with P{hsp26-pt-T}39C-31 pr-set720 non-enhancer of variegation, with P{hsp26-pt-T}39C-50 pr-set720 non-enhancer of variegation, with P{hsp26-pt-T}39C-55 pr-set720 non-enhancer of variegation, with P{hsp26-pt-T}39C-62 pr-set720 non-suppressor of variegation, with P{hsp26-pt-T}39C-27 pr-set720 non-suppressor of variegation, with P{hsp26-pt-T}39C-31 pr-set720 non-suppressor of variegation, with P{hsp26-pt-T}39C-50 pr-set720 non-suppressor of variegation, with P{hsp26-pt-T}39C-55 pr-set720 non-suppressor of variegation, with P{hsp26-pt-T}39C-62 pr-set720 suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10 pr-set720 suppressor of variegation | dominant, with P{hsp26-pt-T}Dyrk3118E-15 pr-set720 visible, with Scer\GAL4pnr-MD237 pr-set7GD10930 Phenotype manifest in Allele chromosome pr-set720 condensed chromosome pr-set720 embryonic/larval brain | third instar larval stage pr-set720 embryonic/larval brain | third instar larval stage (with Df(3R)red3l) pr-set720 embryonic/larval cuticle pr-set720 embryonic/larval cuticle (with Df(3R)red3l) pr-set71 embryonic/larval digestive system (with Df(3R)red3l) pr-set71 embryonic/larval tracheal system pr-set720 eye (with Df(3R)red3l) pr-set71 eye (with pr-set71) pr-set720 eye (with pr-set720) pr-set71 macrochaeta (with Df(3R)red3l) pr-set71 melanotic mass pr-set720 melanotic mass (with Df(3R)red3l) pr-set71 mesothoracic tergum, with Scer\GAL4pnr-MD237 pr-set7GD10930 neuroblast | third instar larval stage pr-set720 ventral thoracic disc pr-set720 wing disc pr-set720 wing margin (with Df(3R)red3l) pr-set71
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of pr-set7 Class Mutagen Stocks Known lesion pr-set71 hypomorphic allele - genetic evidence P-element activity 1 Yes pr-set7EY04668 P-element activity 1 -- pr-set720 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pr-set7 Class Mutagen Stocks Known lesion pr-set7GD10930 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pr-set7GL00228 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pr-set7KK101667 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6267 (Ryder, 2004.4.26) Df(3R)red3l (Spradling et al., 1999, Nishioka et al., 2002, Fang et al., 2002, BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)red1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10930} NA P{KK101667} NA P{TRiP.GL00228} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{hsneo}pr-set71 NA insertion of mobile activating element P{EPgy2}pr-set7EY04668 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
histone methyltransferase activity (H4-K20 specific) inferred from mutant phenotype (Karachentsev et al., 2005, Yang et al., 2008)
Biological Process
CV term Evidence References
chromosome condensation inferred from direct assay (Sakaguchi and Steward, 2007) inferred from genetic interaction with mei-41 (Sakaguchi and Steward, 2007) DNA damage checkpoint inferred from direct assay (Sakaguchi and Steward, 2007) histone H4-K20 monomethylation inferred from mutant phenotype (Yang et al., 2008) histone methylation inferred from mutant phenotype (Nishioka et al., 2002, Fang et al., 2002, Karachentsev et al., 2005)
Cellular Component
CV term Evidence References
polytene chromosome inferred from direct assay (Karachentsev et al., 2005)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
histone methyltransferase activity (H4-K20 specific) non-traceable author statement (Nishioka, 2003.4.24) traceable author statement (Zhimulev and Belyaeva, 2003, Simms et al., 2003)
Biological Process
CV term Evidence References
histone methylation non-traceable author statement (Nishioka, 2003.4.24) traceable author statement (Simms et al., 2003) negative regulation of histone acetylation traceable author statement (Simms et al., 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pr-set7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66819 DroID - A comprehensive database of gene and protein interactions. • FBgn0011474 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41743
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17507 Dere\GG16850 Dgri\GH17478 Dmoj\GI22805 Dper\GL23503 Dpse\GA17259 Dsec\GM24161 Dsim\GD18957 Dvir\GJ22807 Dwil\GK10941 Dyak\GE24231
Curated drosophilid orthologs	Dpse\GA17259
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000193-PA Aedes aegypti (mosquito) AGAP012481-PA Anopheles gambiae (mosquito) XP_395493.3 Apis mellifera (honey bee) CPIJ000732 Culex pipens (mosquito) 311914 Daphnia pulex (daphnia) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18656 NV11710 NV11709 LH18657 ISCW020034 FBgn0241361 FBgn0212952 FBgn0209911 FBgn0190467 FBgn0179025 JGI_V11_311914 FBgn0077272 FBgn0161093 FBgn0145532 FBgn0124948 FBgn0109079 FBgn0094525 CPIJ000732 BGIBMGA012853 ACYPI002722 GB15777 AGAP012481 AAEL000193 PHUM315980 GLEAN_15766
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	35322 y1 sc* v1; P{TRiP.GL00228}attP2/TM3, Sb1 15761 y1 w67c23; P{EPgy2}pr-set7EY04668/TM3, Sb1 Ser1 10278 mwh1 red1 P{hsneo}pr-set71 e1/TM3, ryRK Sb1 Ser1
VDRC	v105424 P{KK101667}VIE-260B v34589 w1118; P{GD10930}v34589 v34590 w1118; P{GD10930}v34590
Genomic Clones ( 1 )
	BACR26A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 89 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD12042
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17024 AT21615 AT21689 LD17320 LD19475 LD29075 LD33343 RE08415 RE16326 RE28246 RE30811 RE32246 RE41674 RE43480 RE46996 RE51028 RE65633 RE66740 RE73225 RE73249 RE73263 RE73376 SD24413
Other clones	7996 10533 34007 39106 40228 45330 50487 53950 57022 74875 75547 105049 119800 121130 125684 160262 162182 166480 181197 214215.26 214247.35 214379.27 282543 CK01.32D.C3 CK01.43B.B1 CK01.50A.F12 CK01.88A.H4 CK01.93C.H4 Dmel_dig_015824_0676_3052 Dmel_neb_010573_0828_3019 EC23419 EC29719 EK037409 EK063042 EK069462 EK072962 EK105823 EK110646 EK128603 EK148729 EK152221 EK153958 EK161222 EK165164 EK170522 EK176456 EK178047 EK205260 EK207123 EK229924 EK239713 EK255407 EK263633 EK269504 EK287253 EK306408 EK308124 EP10855 EP17361 FGC007E03 GM01470 RP004244138 RP004259524 RP004349289 RP004492075
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011474 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41743
Antibody Information
Other Information
Discoverer
	A. Spradling.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: pr-set7 CG3307 (Fang et al., 2002) Source for identity of: pr-set7 CG3307 (Nishioka et al., 2002) Source for identity of: pr-set7 l(3)neo41 (Ketel, 2003.2.10)
Source for database merge of
Additional comments
Other Comments
	Monomethylated H4K20 is strongly reduced in pr-set7 mutant larval brains. (Sakaguchi and Steward, 2007) Double-stranded breaks are not increased in pr-set7 mutants. (Sakaguchi and Steward, 2007) The DNA damage checkpoint, especially the ATR is pathway, is activated in pr-set7 mutants. (Sakaguchi and Steward, 2007) The DNA repair pathway is activated after γ-irradiation in pr-set7 mutants. (Sakaguchi and Steward, 2007) pr-set7 mutations suppress position effect variegation. (Karachentsev et al., 2005) A mutation in pr-set7 decreases levels of H4-K20 methylation in vivo and causes lethality. (Ketel et al., 2003) Disruption of pr-set7 reduces levels of His4 K20 methylation. (Fang et al., 2002) Disruption of pr-set7 results in lethality. (Fang et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142097 NM_169577 NM_169578 RefSeq (Proteins) • NP_650354 NP_731900 NP_731901 DDBJ / EMBL / GenBank • AA392887 AAF55047 AAM27502 AAN13605 AAN13606 AAP35083 AQ026345 AW942217 AY102673 AY283060 Entrez Gene - A searchable database of RefSeq genes. • 41743 UniProtKB/Swiss-Prot • Q9VFK6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SET domain (IPR001214)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66819 DroID - A comprehensive database of gene and protein interactions. • FBgn0011474 DRSC - Results from RNAi screens. • FBgn0011474 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011474 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3307-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011474 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41743 InParanoid A subset of ortholog calls from InParanoid. • AAEL000193-PA Aedes aegypti (mosquito) AGAP012481-PA Anopheles gambiae (mosquito) XP_395493.3 Apis mellifera (honey bee) CPIJ000732 Culex pipens (mosquito) 311914 Daphnia pulex (daphnia) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/prset7-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41743 modMine - Data generated by the modENCODE project. • FBgn0011474 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18656 NV11710 NV11709 LH18657 ISCW020034 FBgn0241361 FBgn0212952 FBgn0209911 FBgn0190467 FBgn0179025 JGI_V11_311914 FBgn0077272 FBgn0161093 FBgn0145532 FBgn0124948 FBgn0109079 FBgn0094525 CPIJ000732 BGIBMGA012853 ACYPI002722 GB15777 AGAP012481 AAEL000193 PHUM315980 GLEAN_15766
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG3307 (Butler et al., 2003, Nishioka et al., 2002, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dSET8 (Ketel et al., 2003) dSet8 (Fang et al., 2002) l(3)neo41 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Cooley et al., 1988, ) PR/SET07 (Zhimulev and Belyaeva, 2003) PR-Set7 (Karachentsev et al., 2005, Karachentsev et al., 2005, Sakaguchi and Steward, 2007, Li et al., 2007, Sakaguchi and Steward, 2007, Yang et al., 2008) pr-set7 (Gan et al., 2010) pr-Set7 (Minakhina and Steward, 2006) Pr-set-7 (Bai et al., 2007) PR-SET7 (Scharf et al., 2009) Set7 (Karachentsev and Steward, 2004, Nishioka, 2003.4.24) Set8 (Schotta et al., 2004, Ketel, 2003.2.10)
Name Synonym	pr-set7
Secondary FlyBase IDs
	FBgn0038222
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 2 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...