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Gene Dmel\cpb

General Information
Symbol	Dmel\cpb	Species	D. melanogaster
Name	capping protein beta	Annotation symbol	CG17158
Feature type	protein_coding_gene	FlyBase ID	FBgn0011570
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	22B1-22B1	Sequence location	2L:1,704,904..1,706,962 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene capping protein beta is referred to in FlyBase by the symbol Dmel\cpb (CG17158, FBgn0011570). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: wing disc development; regulation of lamellipodium assembly; border follicle cell migration; actin cytoskeleton organization; regulation of actin filament length; barbed-end actin filament capping; cytoplasmic transport, nurse cell to oocyte; cell morphogenesis; actin filament organization; negative regulation of filopodium assembly. 15 alleles are reported. The phenotypes of these alleles are annotated with: sternopleural bristle; macrochaeta; border follicle cell; nurse cell. It has one annotated transcript and one annotated polypeptide. Protein features are: F-actin capping protein, beta subunit, conserved site; WASH complex, F-actin capping protein, beta subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630572_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cpb. Gene sequence location is 2L:1704904..1706962.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 Brás-Pereira et al., 2011, Commun. Integr. Biol. 4(5): 612--615 D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 Sequence features BKN21580 HFA00809 Controlled Vocabulary Terms cell morphogenesis
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22B1-22B1   Limits computationally determined from genome sequence between P{PZ}l(2)0411104111 and P{lacW}CG17646k11021
Experimentally Determined Cytological Location
Cytogenetic map Notes References 22A4-22A4     (Hopmann, 1995.8.31) 22A4-22A4   (determined by in situ hybridisation)   (Hopmann et al., 1996) 22A4-22A4   (determined by in situ hybridisation)   (Hopmann, 1995) 22A4-22A4   (determined by in situ hybridisation)   (Hopmann et al., 1994) 22B1-22B1   (determined by in situ hybridisation)   (Hopmann et al., 1993) 22A1-22B   Localised by meiotic and deletion mapping (details unspecified).   (Delalle et al., 2002)
Experimentally Determined Recombination Data
Location	2- (Hopmann, 1995.8.31)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cpb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	extended 3' end
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cpb-RA FBtr0077881  NM_057657   1774   276
Additional Transcript Data & Comments
Reported size (kB)	1.9, 1.8 (northern blot) (Hopmann et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cpb-PA   FBpp0077549   31.4   276   5.08     NP_477005   AAF51349
Additional Polypeptide Data & Comments
Reported size (kDa)	276 (aa); 32 (kD observed) (Hopmann et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WASH complex, F-actin capping protein, beta subunit (IPR001698) F-actin capping protein, beta subunit, conserved site (IPR019771)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264397   AA264433   AA390582   AA390781   AA391917   AA540652   AA803794   AE014134 AAF51349   AC004442   AI256948   AI258667   AI294650   AI297576   AI455757   AI530789   AI533666   AI534713   AI541768   AW944521   AY069829 AAL39974   BI163113   BI164930   BI168567   BI172481   BI241650   BI363633   BI372128   BI372280   BI373653   BI484504   BI578133   BI636502   BI638095   BP541025   CK659158   CK660155   CO177248   CO177582   CO189573   CO189599   CO192493   CO264703   CO285622   CO300988   CO307336   CO310893   CO318452   CO319372   CO325638   CO327974   EC066806   EC069334   EC078563   EC086421   EC207136   EC227510   EC234444   EC236652   EC238820   EC239102   EC241505   EC244351   EC249408   EC256585   EV583126   L80125   U35240 AAB38521
UniProtKB/Swiss-Prot	P48603
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Hopmann et al., 1996)
Additional Descriptive Data
	cpb transcripts are expressed at fairly constant levels in all developmental stages. (Hopmann et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   macrochaeta   (Hopmann et al., 1996) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Hopmann et al., 1996) adult stage   muscle cell of thorax   • Z disc (Hopmann et al., 1996)
Additional Descriptive Data
	cpb protein is expressed in all developmental stages at relatively constant levels. In bristles, nej protein localizes along the length of actin bundles and is found in the periphery of the bristle. In adult flies, cpb protein localizes to the Z discs of thoracic muscles. (Hopmann et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011570    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011570 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011570 expression level Developmental Stage   Expression Level embryo 00-02hr    6185 embryo 02-04hr    9257 embryo 04-06hr    8492 embryo 06-08hr    6523 embryo 08-10hr    6173 embryo 10-12hr    4922 embryo 12-14hr    4561 embryo 14-16hr    4478 embryo 16-18hr    3903 embryo 18-20hr    2736 embryo 20-22hr    2600 embryo 22-24hr    2751 larva L1    2170 larva L2    3476 larva L3 12hr old    2443 larva L3 puffstage 1-2    3554 larva L3 puffstage 3-6    4873 larva L3 puffstage 7-9    5990 white prepupae new    6715 white prepupae 12hr    4231 white prepupae 24hr    4298 pupae 2d postWPP    3831 pupae 3d postWPP    2275 pupae 4d postWPP    1588 adult male 01day    1541 adult male 05day    1581 adult male 30day    1746 adult female 01day    2902 adult female 05day    4346 adult female 30day    4362 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6185) embryo 02-04hr  (9257) embryo 04-06hr  (8492) embryo 06-08hr  (6523) embryo 08-10hr  (6173) embryo 10-12hr  (4922) embryo 12-14hr  (4561) embryo 14-16hr  (4478) embryo 16-18hr  (3903) embryo 18-20hr  (2736) embryo 20-22hr  (2600) embryo 22-24hr  (2751) larva L1  (2170) larva L2  (3476) larva L3 12hr old  (2443) larva L3 puffstage 1-2  (3554) larva L3 puffstage 3-6  (4873) larva L3 puffstage 7-9  (5990) white prepupae new  (6715) white prepupae 12hr  (4231) white prepupae 24hr  (4298) pupae 2d postWPP  (3831) pupae 3d postWPP  (2275) pupae 4d postWPP  (1588) adult male 01day  (1541) adult male 05day  (1581) adult male 30day  (1746) adult female 01day  (2902) adult female 05day  (4346) adult female 30day  (4362) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6185) embryo 02-04hr  (9257) embryo 04-06hr  (8492) embryo 06-08hr  (6523) embryo 08-10hr  (6173) embryo 10-12hr  (4922) embryo 12-14hr  (4561) embryo 14-16hr  (4478) embryo 16-18hr  (3903) embryo 18-20hr  (2736) embryo 20-22hr  (2600) embryo 22-24hr  (2751) larva L1  (2170) larva L2  (3476) larva L3 12hr old  (2443) larva L3 puffstage 1-2  (3554) larva L3 puffstage 3-6  (4873) larva L3 puffstage 7-9  (5990) white prepupae new  (6715) white prepupae 12hr  (4231) white prepupae 24hr  (4298) pupae 2d postWPP  (3831) pupae 3d postWPP  (2275) pupae 4d postWPP  (1588) adult male 01day  (1541) adult male 05day  (1581) adult male 30day  (1746) adult female 01day  (2902) adult female 05day  (4346) adult female 30day  (4362) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6185 embryo 02-04hr    9257 embryo 04-06hr    8492 embryo 06-08hr    6523 embryo 08-10hr    6173 embryo 10-12hr    4922 embryo 12-14hr    4561 embryo 14-16hr    4478 embryo 16-18hr    3903 embryo 18-20hr    2736 embryo 20-22hr    2600 embryo 22-24hr    2751 larva L1    2170 larva L2    3476 larva L3 12hr old    2443 larva L3 puffstage 1-2    3554 larva L3 puffstage 3-6    4873 larva L3 puffstage 7-9    5990 white prepupae new    6715 white prepupae 12hr    4231 white prepupae 24hr    4298 pupae 2d postWPP    3831 pupae 3d postWPP    2275 pupae 4d postWPP    1588 adult male 01day    1541 adult male 05day    1581 adult male 30day    1746 adult female 01day    2902 adult female 05day    4346 adult female 30day    4362 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6185 embryo 02-04hr    9257 embryo 04-06hr    8492 embryo 06-08hr    6523 embryo 08-10hr    6173 embryo 10-12hr    4922 embryo 12-14hr    4561 embryo 14-16hr    4478 embryo 16-18hr    3903 embryo 18-20hr    2736 embryo 20-22hr    2600 embryo 22-24hr    2751 larva L1    2170 larva L2    3476 larva L3 12hr old    2443 larva L3 puffstage 1-2    3554 larva L3 puffstage 3-6    4873 larva L3 puffstage 7-9    5990 white prepupae new    6715 white prepupae 12hr    4231 white prepupae 24hr    4298 pupae 2d postWPP    3831 pupae 3d postWPP    2275 pupae 4d postWPP    1588 adult male 01day    1541 adult male 05day    1581 adult male 30day    1746 adult female 01day    2902 adult female 05day    4346 adult female 30day    4362 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011570 expression level Developmental Stage   Expression Level embryo 00-02hr    6185 embryo 02-04hr    9257 embryo 04-06hr    8492 embryo 06-08hr    6523 embryo 08-10hr    6173 embryo 10-12hr    4922 embryo 12-14hr    4561 embryo 14-16hr    4478 embryo 16-18hr    3903 embryo 18-20hr    2736 embryo 20-22hr    2600 embryo 22-24hr    2751 larva L1    2170 larva L2    3476 larva L3 12hr old    2443 larva L3 puffstage 1-2    3554 larva L3 puffstage 3-6    4873 larva L3 puffstage 7-9    5990 white prepupae new    6715 white prepupae 12hr    4231 white prepupae 24hr    4298 pupae 2d postWPP    3831 pupae 3d postWPP    2275 pupae 4d postWPP    1588 adult male 01day    1541 adult male 05day    1581 adult male 30day    1746 adult female 01day    2902 adult female 05day    4346 adult female 30day    4362 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6185) embryo 02-04hr  (9257) embryo 04-06hr  (8492) embryo 06-08hr  (6523) embryo 08-10hr  (6173) embryo 10-12hr  (4922) embryo 12-14hr  (4561) embryo 14-16hr  (4478) embryo 16-18hr  (3903) embryo 18-20hr  (2736) embryo 20-22hr  (2600) embryo 22-24hr  (2751) larva L1  (2170) larva L2  (3476) larva L3 12hr old  (2443) larva L3 puffstage 1-2  (3554) larva L3 puffstage 3-6  (4873) larva L3 puffstage 7-9  (5990) white prepupae new  (6715) white prepupae 12hr  (4231) white prepupae 24hr  (4298) pupae 2d postWPP  (3831) pupae 3d postWPP  (2275) pupae 4d postWPP  (1588) adult male 01day  (1541) adult male 05day  (1581) adult male 30day  (1746) adult female 01day  (2902) adult female 05day  (4346) adult female 30day  (4362) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6185) embryo 02-04hr  (9257) embryo 04-06hr  (8492) embryo 06-08hr  (6523) embryo 08-10hr  (6173) embryo 10-12hr  (4922) embryo 12-14hr  (4561) embryo 14-16hr  (4478) embryo 16-18hr  (3903) embryo 18-20hr  (2736) embryo 20-22hr  (2600) embryo 22-24hr  (2751) larva L1  2170 larva L2  (3476) larva L3 12hr old  2443 larva L3 puffstage 1-2  (3554) larva L3 puffstage 3-6  (4873) larva L3 puffstage 7-9  (5990) white prepupae new  (6715) white prepupae 12hr  (4231) white prepupae 24hr  (4298) pupae 2d postWPP  (3831) pupae 3d postWPP  2275 pupae 4d postWPP  1588 adult male 01day  1541 adult male 05day  1581 adult male 30day  1746 adult female 01day  (2902) adult female 05day  (4346) adult female 30day  (4362) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6185 embryo 02-04hr    9257 embryo 04-06hr    8492 embryo 06-08hr    6523 embryo 08-10hr    6173 embryo 10-12hr    4922 embryo 12-14hr    4561 embryo 14-16hr    4478 embryo 16-18hr    3903 embryo 18-20hr    2736 embryo 20-22hr    2600 embryo 22-24hr    2751 larva L1    2170 larva L2    3476 larva L3 12hr old    2443 larva L3 puffstage 1-2    3554 larva L3 puffstage 3-6    4873 larva L3 puffstage 7-9    5990 white prepupae new    6715 white prepupae 12hr    4231 white prepupae 24hr    4298 pupae 2d postWPP    3831 pupae 3d postWPP    2275 pupae 4d postWPP    1588 adult male 01day    1541 adult male 05day    1581 adult male 30day    1746 adult female 01day    2902 adult female 05day    4346 adult female 30day    4362 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6185 embryo 02-04hr    9257 embryo 04-06hr    8492 embryo 06-08hr    6523 embryo 08-10hr    6173 embryo 10-12hr    4922 embryo 12-14hr    4561 embryo 14-16hr    4478 embryo 16-18hr    3903 embryo 18-20hr    2736 embryo 20-22hr    2600 embryo 22-24hr    2751 larva L1    2170 larva L2    3476 larva L3 12hr old    2443 larva L3 puffstage 1-2    3554 larva L3 puffstage 3-6    4873 larva L3 puffstage 7-9    5990 white prepupae new    6715 white prepupae 12hr    4231 white prepupae 24hr    4298 pupae 2d postWPP    3831 pupae 3d postWPP    2275 pupae 4d postWPP    1588 adult male 01day    1541 adult male 05day    1581 adult male 30day    1746 adult female 01day    2902 adult female 05day    4346 adult female 30day    4362 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011570    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011570 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011570 expression level Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut    667.3 Larval Hindgut    584.6 Larval Malpighian Tubules    876.4 Larval Fat Body    558.7 Larval Salivary Gland    720.3 Larval Trachea    491.6 Larval Carcass    565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut  (667.3) Larval Hindgut  (584.6) Larval Malpighian Tubules  (876.4) Larval Fat Body  (558.7) Larval Salivary Gland  (720.3) Larval Trachea    491.6 Larval Carcass  (565.9) Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut    667.3 Larval Hindgut    584.6 Larval Malpighian Tubules    876.4 Larval Fat Body    558.7 Larval Salivary Gland    720.3 Larval Trachea    491.6 Larval Carcass    565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut    667.3 Larval Hindgut    584.6 Larval Malpighian Tubules    876.4 Larval Fat Body    558.7 Larval Salivary Gland    720.3 Larval Trachea    491.6 Larval Carcass    565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011570 expression level Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut    667.3 Larval Hindgut    584.6 Larval Malpighian Tubules    876.4 Larval Fat Body    558.7 Larval Salivary Gland    720.3 Larval Trachea    491.6 Larval Carcass    565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut  667.3 Larval Hindgut  584.6 Larval Malpighian Tubules  (876.4) Larval Fat Body  558.7 Larval Salivary Gland  720.3 Larval Trachea    491.6 Larval Carcass  565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut    667.3 Larval Hindgut    584.6 Larval Malpighian Tubules    876.4 Larval Fat Body    558.7 Larval Salivary Gland    720.3 Larval Trachea    491.6 Larval Carcass    565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    418.35 Larval Midgut    667.3 Larval Hindgut    584.6 Larval Malpighian Tubules    876.4 Larval Fat Body    558.7 Larval Salivary Gland    720.3 Larval Trachea    491.6 Larval Carcass    565.9 Adult Head    157.2 Adult Eye    190.425 Adult Brain    183.2 Adult Thoracic-Abdominal Ganglion    154.5 Adult Crop    384.1 Adult Midgut    428.4 Adult Hindgut    356.3 Adult Malpighian Tubules    320.7 Adult Fat Body    104.1 Adult Salivary Gland    445 Adult Heart    218.05 Adult VirginFemale Spermatheca    127.1 Adult InseminatedFemale Spermatheca    138.9 Adult Ovary    450 Adult Testis    108.7 Adult Male Accessory Gland    422.5 Adult Carcass    141.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    157.2   NA  Eye    190.425   NA  Brain    183.2   418.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    154.5   NA  Crop    384.1   667.3  Midgut    428.4   584.6  Hindgut    356.3   876.4  Malpighian Tubules    320.7   558.7  Fat Body    104.1   720.3  Salivary Gland    445   NA  Heart    218.05   491.6  Trachea    NA   NA  VirginFemale Spermatheca    127.1   NA  InseminatedFemale Spermatheca    138.9   NA  Ovary    450   NA  Testis    108.7   NA  Male Accessory Gland    422.5   565.9  Carcass    141.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011570 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17158-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cpb Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with cpbbnd1) cpbbnd2 cpbbnd3 lethal (with cpbbnd2) cpbbnd1 cpbbnd3 lethal (with cpbbnd3) cpbbnd1 cpbbnd2 lethal | larval stage | recessive cpb6.15 cpbF19 lethal | recessive cpbbnd1 cpbbnd2 cpbbnd3 cpbM143 semi-lethal (with cpb6.15) cpbF19 semi-lethal (with cpbF19) cpb6.15 Sterility Allele fertile | male cpb6.15 cpbF19 semi-sterile | dominant | female cpb6.15 cpbF19 Other Phenotypes Allele developmental rate defective (with cpb6.15) cpbF19 developmental rate defective (with cpbF19) cpb6.15 visible | recessive | somatic clone cpbunspecified wild-type cpb+t4.5 Phenotype manifest in Allele actin cytoskeleton & eye disc | somatic clone cpbbnd1 actin filament & dorsal mesothoracic disc & pupa | somatic clone cpb4.18 actin filament & egg chamber (with cpb6.15) cpbF19 actin filament & egg chamber (with cpbF19) cpb6.15 adult abdomen | somatic clone cpbunspecified border follicle cell, with Scer\GAL4slbo.2.6 cpbScer\UAS.cWa chaeta | somatic clone cpbunspecified egg | maternal effect (with cpb6.15) cpbF19 egg | maternal effect (with cpbF19) cpb6.15 eye | somatic clone cpbM143 cpbunspecified eye photoreceptor cell & nucleus | somatic clone cpbM143 eye photoreceptor cell | somatic clone cpbunspecified filopodium | supernumerary cpbbnd1 cpbbnd2 cpbbnd3 interommatidial bristle | somatic clone cpbunspecified macrochaeta (with cpb6.15) cpbF19 macrochaeta (with cpbF19) cpb6.15 macrochaeta & head cpb6.15 cpbF19 macrochaeta & thorax cpb6.15 cpbF19 nurse cell (with cpb6.15) cpbF19 nurse cell (with cpbF19) cpb6.15 ommatidium | somatic clone cpbM143 cpbunspecified rhabdomere | somatic clone cpbM143 sternopleural bristle (with cpb6.15) cpbF19 sternopleural bristle (with cpbF19) cpb6.15 trichogen cell & actin filament & pupa (with cpb6.15) cpbF19 trichogen cell & actin filament & pupa (with cpbF19) cpb6.15 wing | somatic clone cpbunspecified wing disc | somatic clone cpbM143
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of cpb Class Mutagen Stocks Known lesion cpbM143 ethyl methanesulfonate 2 Yes cpb6.15 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- cpbDP00046 1 -- cpbF19 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes cpb1 0 -- cpb4.18 0 Yes cpbbnd1 ethyl methanesulfonate 0 Yes cpbbnd2 ethyl methanesulfonate 0 Yes cpbbnd3 ethyl methanesulfonate 0 Yes cpbF44 ethyl methanesulfonate 0 Yes cpbunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cpb Class Mutagen Stocks Known lesion cpbGD9299 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cpbJF02068 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cpb+t4.5 in vitro construct - genomic fragment 0 Yes cpbScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ast2 (Delalle et al., 2005, Hopmann et al., 1996) Df(2L)BSC480 (Christensen et al., 2008.4.15) Df(2L)BSC521 (Christensen et al., 2008.4.15) Df(2L)dp-79b (Hopmann et al., 1996) Df(2L)E.2 (Whited et al., 2004, Whited et al., 2004) Df(2L)Exel6005 (Ryder, 2004.4.26) Df(2L)S2 (Welte, 2000.2.23, Delalle et al., 2005)
Not disrupted in	Df(2L)al (Delalle et al., 2005) Df(2L)F.1 (Collier et al., 2005) Df(2L)S3 (Welte, 2000.2.23, Delalle et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9299} NA P{TRiP.JF02068} NA P{UAS-cpb.W} NA characterization construct P{cpb+t4.5} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}cpbDP00046 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Delalle et al., 2005) actin filament organization inferred from mutant phenotype (Kiger et al., 2003, Gates et al., 2009) barbed-end actin filament capping inferred from direct assay (Hopmann et al., 1996) border follicle cell migration inferred from mutant phenotype (Gates et al., 2009) cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) cytoplasmic transport, nurse cell to oocyte inferred from mutant phenotype (Gates et al., 2009) negative regulation of filopodium assembly inferred from mutant phenotype (Gonçalves-Pimentel et al., 2011) regulation of actin filament length inferred from mutant phenotype (Rogers et al., 2003) regulation of lamellipodium assembly inferred from mutant phenotype (Iwasa and Mullins, 2007) wing disc development inferred from mutant phenotype (Janody and Treisman, 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with UniProtKB:P79136 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR001698, InterPro:IPR019771 (FlyBase Curators et al., 2004-) F-actin capping protein complex inferred from sequence or structural similarity with UniProtKB:P79136 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cpb allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59586 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011570 DroID - A comprehensive database of gene and protein interactions. • FBgn0011570 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33346
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20820 Dere\GG24802 Dgri\GH11421 Dmoj\GI14594 Dper\GL18775 Dpse\GA14356 Dsec\GM16827 Dsim\GD23110 Dvir\GJ17098 Dwil\GK15203 Dyak\GE17670
Curated drosophilid orthologs	Dpse\GA14356
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002184-PA Aedes aegypti (mosquito) AGAP007864-PA Anopheles gambiae (mosquito) XP_393085.2 Apis mellifera (honey bee) XP_001946713.1 Acyrthosiphon pisum (pea aphid) At1g71790.1 Arabidopsis thaliana (wall cress) 15823 Batrachochytrium dendrobatidis (chytrid fungus) 96273 Branchiostoma floridae (lancelet) XP_001900861.1 Brugia malayi (roundworm nematode) BGIBMGA009430-PA Bombyx mori (silk worm) ENSBTAP00000005983 Bos taurus (bovine) CAL0002953 Candida albicans (a form of yeast) CN02168 Caenorhabditis brenneri (small nematode) CBP21205 Caenorhabditis briggsae (nematode) CE01608 Caenorhabditis elegans (worm) ENSCAFP00000022331 Canis familiaris (dog) CAGL0I05214g Candida glabrata (haploid yeast) ENSCINP00000012161 Ciona intestinalis (sea squirt) JA05345 Caenorhabditis japonica (nematode) cn02187 Cryptococcus neoformans (yeast-like fungus) cgd1_3460 Cryptosporidium parvum (protozoan parasite) CPIJ010373 Culex pipens (mosquito) ENSCPOP00000012548 Cavia porcellus (guinea pig) RP48078 Caenorhabditis remanei (nematode) ENSCSAVP00000015430 Ciona savignyi (sedentary tunicate) 181882 Capitella spl (polychaete worm) DDB0191202 Dictyostelium discoideum (amoeba) DEHA2B03190g Debaryomyces Hansenii (yeast) 304315 Daphnia pulex (daphnia) ENSDARP00000067634 Danio rerio (zebra fish) ENSECAP00000007282 Equus caballus (horse) XP_652863 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000001394 Gymnopilus aculeatus (mushroom) ENSGALP00000006415 Gallus gallus (chicken) 86506 Hypsipyla robusta (cedar shoot borer) ENSP00000264202 Homo sapiens (human) KLLA0E04225g Kluyveromyces lactis (yeast) 234041 Lottia gigantea (owl limpet) 33636 Monocosta brevicollis (choanoflagellate) ENSMODP00000019823 Monodelphis domestica (gray opossum) ENSMMUP00000009052 Macaca mulatta (rhesus monkey) ENSMUSP00000030518 Mus musculus (house mouse) 181966 Nematostella vectensis (starlet anemone) XP_001607231.1 Nasonia vitripennis (wasp) ENSOANP00000024142 Ornithorynchus anatinus (platypus) ENSORLP00000000187 Oryzias latipes (japanese killifish) LOC_Os03g26450.1 Oryza sativa (asian rice) PFE0880c Plasmodium falciparum (protozoal parasite) PHUM003640-PA Pediculus humanus (human body louse) PP08356 Pristionchus pacificus (nematode) 108319 Physcomitrella patens (moss) ENSPPYP00000002073 Pongo pygmaeus (orangutan) 71609 Phytophthora ramorum (sudden oak death pathogen) 108338 Phytophthora sojae (root rot pathogen) 831563 Populus trichocarpa (black cottonwood) ENSPTRP00000000470 Pan troglodytes (chimpanzee) PVX_080370 Plasmodium vivax (protozoal parasite) ENSRNOP00000010002 Rattus norvegicus (norway rat) 4870615 Sorghum bicolor (sorghum) YIL034C Saccharomyces cerevisiae (budding yeast) Smp_186650 Schistosoma mansoni (trematode parasite) SPAC631.01c Schizosaccharomyces pombe (fission yeast) XP_001178378.1 Strongylocentrotus purpuratus (purple sea urchin) 64014 Trichoplax adhaerens (metazoa) XP_971537.1 Tribolium castaneum (red flour beetle) Tc00.1047053506363.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506975.49 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017681 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024811 Takifugu rubripes (pufferfish Takifugu) 3813.m01624 Tetrahymena thermophila (ciliate protozoa) 94095.m00087 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000038232 Xenopus tropicalis (frog) YALI0C20735g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12834 LH18950 ISCW009966 FBgn0235120 FBgn0217208 FBgn0204275 FBgn0194500 FBgn0171740 JGI_V11_304315 FBgn0074384 FBgn0156376 FBgn0137345 FBgn0118901 FBgn0116932 FBgn0097826 CPIJ010373 CPIJ019319 BGIBMGA009430 ACYPI000695 GB18637 AGAP007864 AAEL002184 PB20139 PHUM126830 GLEAN_06343
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	26298 y1 v1; P{TRiP.JF02068}attP2 8742 w*; cpb6.15/CyO, P{lacZ-un3}276 8808 cpbF19 cn1 bw1 sp1/CyO 5586 cpbM143 cn1 bw1 sp1/CyO 21791 y1 w67c23; P{Mae-UAS.6.11}cpbDP00046/CyO
Kyoto	108318 cpbM143 cn1 b1 sp1/CyO
VDRC	v45668 w1118; P{GD9299}v45668
Genomic Clones ( 1 )
	BACR19B15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD07714
Other clones	DPiM_SD07714
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM14288 LD08128 LD08151 LD08809 LD09603 LD10826 LD20415 LD35436 LP01914 LP04030 LP08071 LP11907 LP16719 LP18463 RE02436 RE04707 RE09356 RE14986 RE38768 RE48533 RE59009 RE59209 RE61005 RE67619 RE71950 SD01507 SD05565 SD06921 SD18195 SD20301
Other clones	54646 Dmel_dig_020349_0713_3153 EC33887 EK044561 EK044655 EK053012 EK053844 EK139958 EK169705 EK179842 EK197014 EK222921 EK254363 EK272162 EK277821 EP08347 FGA009H10
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33346 251582
Antibody Information
	polyclonal (Hopmann et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cpb burned (Delalle et al., 2005)
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Identification: in a screen for mutations that cause retinal degeneration in homozygous clones in the eye. (Delalle et al., 2002) Homozygous clones in the retina are darkly pigmented with no discernible ommatidial organisation. The degeneration has already occurred at eclosion and still occurs in flies reared in complete darkness. (Delalle et al., 2002) Molecular and genetic characterisation reveals cpb has an essential function during development. cpb is required to regulate actin assembly during the development of specialised structures that depend on actin for their morphology. (Hopmann et al., 1996) In mutants affecting Actn, an actin crosslinker, capping protein shows allele-specific alterations in its distribution but it is still seen in the Z discs. (Hopmann et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057657 RefSeq (Proteins) • NP_477005 DDBJ / EMBL / GenBank • AAB38521 AAF51349 AAL39974 AC004442 AI534713 AW944521 AY069829 L80125 U35240 Entrez Gene - A searchable database of RefSeq genes. • 33346 UniProtKB/Swiss-Prot • P48603
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WASH complex, F-actin capping protein, beta subunit (IPR001698) F-actin capping protein, beta subunit, conserved site (IPR019771)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59586 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011570 DroID - A comprehensive database of gene and protein interactions. • FBgn0011570 DRSC - Results from RNAi screens. • FBgn0011570 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011570 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17158-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33346 251582 InParanoid A subset of ortholog calls from InParanoid. • AAEL002184-PA Aedes aegypti (mosquito) AGAP007864-PA Anopheles gambiae (mosquito) XP_393085.2 Apis mellifera (honey bee) XP_001946713.1 Acyrthosiphon pisum (pea aphid) At1g71790.1 Arabidopsis thaliana (wall cress) 15823 Batrachochytrium dendrobatidis (chytrid fungus) 96273 Branchiostoma floridae (lancelet) XP_001900861.1 Brugia malayi (roundworm nematode) BGIBMGA009430-PA Bombyx mori (silk worm) ENSBTAP00000005983 Bos taurus (bovine) CAL0002953 Candida albicans (a form of yeast) CN02168 Caenorhabditis brenneri (small nematode) CBP21205 Caenorhabditis briggsae (nematode) CE01608 Caenorhabditis elegans (worm) ENSCAFP00000022331 Canis familiaris (dog) CAGL0I05214g Candida glabrata (haploid yeast) ENSCINP00000012161 Ciona intestinalis (sea squirt) JA05345 Caenorhabditis japonica (nematode) cn02187 Cryptococcus neoformans (yeast-like fungus) cgd1_3460 Cryptosporidium parvum (protozoan parasite) CPIJ010373 Culex pipens (mosquito) ENSCPOP00000012548 Cavia porcellus (guinea pig) RP48078 Caenorhabditis remanei (nematode) ENSCSAVP00000015430 Ciona savignyi (sedentary tunicate) 181882 Capitella spl (polychaete worm) DDB0191202 Dictyostelium discoideum (amoeba) DEHA2B03190g Debaryomyces Hansenii (yeast) 304315 Daphnia pulex (daphnia) ENSDARP00000067634 Danio rerio (zebra fish) ENSECAP00000007282 Equus caballus (horse) XP_652863 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000001394 Gymnopilus aculeatus (mushroom) ENSGALP00000006415 Gallus gallus (chicken) 86506 Hypsipyla robusta (cedar shoot borer) ENSP00000264202 Homo sapiens (human) KLLA0E04225g Kluyveromyces lactis (yeast) 234041 Lottia gigantea (owl limpet) 33636 Monocosta brevicollis (choanoflagellate) ENSMODP00000019823 Monodelphis domestica (gray opossum) ENSMMUP00000009052 Macaca mulatta (rhesus monkey) ENSMUSP00000030518 Mus musculus (house mouse) 181966 Nematostella vectensis (starlet anemone) XP_001607231.1 Nasonia vitripennis (wasp) ENSOANP00000024142 Ornithorynchus anatinus (platypus) ENSORLP00000000187 Oryzias latipes (japanese killifish) LOC_Os03g26450.1 Oryza sativa (asian rice) PFE0880c Plasmodium falciparum (protozoal parasite) PHUM003640-PA Pediculus humanus (human body louse) PP08356 Pristionchus pacificus (nematode) 108319 Physcomitrella patens (moss) ENSPPYP00000002073 Pongo pygmaeus (orangutan) 71609 Phytophthora ramorum (sudden oak death pathogen) 108338 Phytophthora sojae (root rot pathogen) 831563 Populus trichocarpa (black cottonwood) ENSPTRP00000000470 Pan troglodytes (chimpanzee) PVX_080370 Plasmodium vivax (protozoal parasite) ENSRNOP00000010002 Rattus norvegicus (norway rat) 4870615 Sorghum bicolor (sorghum) YIL034C Saccharomyces cerevisiae (budding yeast) Smp_186650 Schistosoma mansoni (trematode parasite) SPAC631.01c Schizosaccharomyces pombe (fission yeast) XP_001178378.1 Strongylocentrotus purpuratus (purple sea urchin) 64014 Trichoplax adhaerens (metazoa) XP_971537.1 Tribolium castaneum (red flour beetle) Tc00.1047053506363.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506975.49 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017681 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024811 Takifugu rubripes (pufferfish Takifugu) 3813.m01624 Tetrahymena thermophila (ciliate protozoa) 94095.m00087 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000038232 Xenopus tropicalis (frog) YALI0C20735g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33346 modMine - Data generated by the modENCODE project. • FBgn0011570 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12834 LH18950 ISCW009966 FBgn0235120 FBgn0217208 FBgn0204275 FBgn0194500 FBgn0171740 JGI_V11_304315 FBgn0074384 FBgn0156376 FBgn0137345 FBgn0118901 FBgn0116932 FBgn0097826 CPIJ010373 CPIJ019319 BGIBMGA009430 ACYPI000695 GB18637 AGAP007864 AAEL002184 PB20139 PHUM126830 GLEAN_06343
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	bnd (Delalle et al., 2005) CAPB_DROME (Storm and Sonnhammer, 2003) CapZ (Jacinto and Baum, 2003) CG17158 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Perkins et al., 2009.3.31) CP (Wear and Cooper, 2004) cpb (Janody and Treisman, 2006, Fernández et al., 2011, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Bakal et al., 2007, Johnson et al., 2008, Frank et al., 2006, Pham et al., 2008, Gates et al., 2009, Foley et al., 2010, Gonçalves-Pimentel et al., 2011, Kuzina et al., 2011) Cpb (Rebelo and Janody, 2007) CPB (Gates et al., 2007) CP-β (Rogat and Miller, 2002) J (Welte, 2000.2.23)
Name Synonym	actin capping protein β (Kuzina et al., 2011) Ancpβ   burned (Delalle et al., 2002, ) capping protein (Petit et al., 2002, Hopmann and Miller, 2002, Hopmann and Miller, 2001, Rogat and Miller, 2002) Capping protein (Rogers et al., 2003) Capping Protein (Nowotarski et al., 2008) capping protein beta (Hopmann, 1995.8.31, Hopmann et al., 1996, Pham et al., 2008, Johnson et al., 2008) Capping protein beta (Rebelo and Janody, 2007, Gates et al., 2007) capping protein Β (D'Ambrosio and Vale, 2010) capping protein β (Rogers et al., 2003, Frank et al., 2006, Sánchez-Soriano et al., 2010) Capping-protein-β   Capping protein β (Janody and Treisman, 2006, Iwasa and Mullins, 2007) capping proteinβ (Gates et al., 2009) CP β subunit (Hopmann et al., 1996)
Secondary FlyBase IDs
	FBgn0015012 FBgn0061517
References ( 71 )
Generate a list of	All references relating to this gene ( 71 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 7 ) Review  ( 5 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 15 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 10 )
	Brás-Pereira et al., 2011, Commun. Integr. Biol. 4(5): 612--615 Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway. [FBrf0216670] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Gonçalves-Pimentel et al., 2011, PLoS ONE 6(3): e18340 Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. [FBrf0213367] Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. [FBrf0216680] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Foley et al., 2010, Biol. Letts 6(1): 102--105 Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? [FBrf0209672] Sánchez-Soriano et al., 2010, Dev. Neurobiol. 70(1): 58--71 Drosophila growth cones: a genetically tractable platform for the analysis of axonal growth dynamics. [FBrf0209638] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...