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Gene Dmel\caz

General Information
Symbol	Dmel\caz	Species	D. melanogaster
Name	cabeza	Annotation symbol	CG3606
Feature type	protein_coding_gene	FlyBase ID	FBgn0011571
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	SARFH, P19
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	14B8-14B9	Sequence location	X:16,182,843..16,187,553 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cabeza is referred to in FlyBase by the symbol Dmel\caz (CG3606, FBgn0011571). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: compound eye development; adult locomotory behavior; positive regulation of motor neuron apoptotic process; larval locomotory behavior. 14 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; A1-7 ventral longitudinal muscle 3; A1-7 ventral longitudinal muscle 4; wing; ommatidium. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain; Zinc finger, RanBP2-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult Malpighian tubules, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634362_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of caz. Gene sequence location is X:16182843..16187553.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14B8-14B9   Limits computationally determined from genome sequence between P{EP}kat80EP620&P{EP}cazEP1564 and P{EP}Cyp1EP1073&P{EP}Dsp1EP355
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14-14     (Immanuel, 1994.8.8) 14B-14B   (determined by in situ hybridisation)   (Immanuel et al., 1995)
Experimentally Determined Recombination Data
Location	1- (Immanuel, 1994.8.8)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\caz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region. Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) caz-RB FBtr0074217  NM_078641   1666   399 caz-RC FBtr0334990  NM_167493   1621   384 caz-RD FBtr0334991  NM_001272672   1534   355 caz-RE FBtr0334992  NM_001272673   1631   124
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein caz-PB   FBpp0073996   38.8   399   9.72     NP_523365   AAN09389 caz-PC   FBpp0307000   37.3   384   9.78     NP_727946   AAF48578 caz-PD   FBpp0307001   34.3   355   9.78     NP_001259601   AGB95443 caz-PE   FBpp0307002   13.7   124   11.71     NP_001259602   AGB95444
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, RanBP2-type (IPR001876) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201394   AA202136   AA263238   AA390745   AA392581   AA441465   AA697002   AA697152   AA802002   AA820124   AA949010   AA979197   AE014298 AAF48578   AE014298 AAN09389   AE014298 AGB95443   AE014298 AGB95444   AI114013   AI134540   AI455298   AI534083   AI546184   AI546318   AI546328   AI546331   AW941337   AY094763 AAM11116   BI165566   BI166173   BI228161   BI352391   BI483767   BI487216   BI577590   BI577923   BI579440   BI579473   BI639817   BP553150   BP553151   BT004875 AAO45231   CK661373   CK662055   CO270876   CO277568   CO286426   CO306670   CO314736   CO339163   EC070966   EC076859   EC076981   EC082342   EC207476   EC209770   EC220651   EC256390   EL877411   EL877486   EV576710   EV585175   L37083 AAC41563   M15765 AAA70425   U13178 AAA86955
UniProtKB/Swiss-Prot	Q27294
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval central nervous system   • nucleoplasm (Sasayama et al., 2012) adult stage   adult central nervous system   • nucleoplasm (Sasayama et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleoplasm inferred from direct assay (Sasayama et al., 2012) nucleus inferred from direct assay (Immanuel et al., 1995, Wang et al., 2011) colocalizes_with transcriptionally active chromatin inferred from direct assay (Immanuel et al., 1995)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult Malpighian tubules, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (894.725) Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea  (592.95) Larval Carcass    337.575 Adult Head    313.8 Adult Eye  (555.275) Adult Brain  (785) Adult Thoracic-Abdominal Ganglion  (607.4) Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules  (624.1) Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary  (724.1) Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (894.725) Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea  592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye  555.275 Adult Brain  785 Adult Thoracic-Abdominal Ganglion  607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules  624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary  724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    313.8   NA  Eye    555.275   NA  Brain    785   894.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    607.4   NA  Crop    281.6   275.2  Midgut    296.6   329.9  Hindgut    287.7   336.8  Malpighian Tubules    624.1   335.8  Fat Body    231.1   419.1  Salivary Gland    297.3   NA  Heart    356.375   592.95  Trachea    NA   NA  VirginFemale Spermatheca    348   NA  InseminatedFemale Spermatheca    457.7   NA  Ovary    724.1   NA  Testis    147   NA  Male Accessory Gland    167.4   337.575  Carcass    224.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    149 central nervous system, larvae L3    192 central nervous system, pupae P8    74 head, virgin 1-day female    39 head, virgin 4-day female    48 head, virgin 20-day female    30 head, mated 1-day female    39 head, mated 4-day female    43 head, mated 20-day female    31 head, mated 1-day male    53 head, mated 4-day male    62 head, mated 20-day male    72 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    44 digestive system, 1-day adult    27 digestive system, 4-day adult    48 digestive system, 20-day adult    42 fat body, larvae L3 wandering    26 fat body, white prepupae    43 fat body, pupae P8    70 carcass, larvae L3 wandering    128 carcass, 1-day adult    22 carcass, 4-day adult    36 carcass, 20-day adult    27 ovary, virgin 4-day female    89 ovary, mated 4-day female    99 testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (149) central nervous system, larvae L3  (192) central nervous system, pupae P8  (74) head, virgin 1-day female  (39) head, virgin 4-day female  (48) head, virgin 20-day female  (30) head, mated 1-day female  (39) head, mated 4-day female  (43) head, mated 20-day female  (31) head, mated 1-day male  (53) head, mated 4-day male  (62) head, mated 20-day male  (72) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  (44) digestive system, 1-day adult  (27) digestive system, 4-day adult  (48) digestive system, 20-day adult  (42) fat body, larvae L3 wandering  26 fat body, white prepupae  (43) fat body, pupae P8  (70) carcass, larvae L3 wandering  (128) carcass, 1-day adult    22 carcass, 4-day adult  (36) carcass, 20-day adult  (27) ovary, virgin 4-day female  (89) ovary, mated 4-day female  (99) testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (149) central nervous system, larvae L3  (192) central nervous system, pupae P8    74 head, virgin 1-day female    39 head, virgin 4-day female    48 head, virgin 20-day female    30 head, mated 1-day female    39 head, mated 4-day female    43 head, mated 20-day female    31 head, mated 1-day male    53 head, mated 4-day male    62 head, mated 20-day male    72 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    44 digestive system, 1-day adult    27 digestive system, 4-day adult    48 digestive system, 20-day adult    42 fat body, larvae L3 wandering    26 fat body, white prepupae    43 fat body, pupae P8    70 carcass, larvae L3 wandering  (128) carcass, 1-day adult    22 carcass, 4-day adult    36 carcass, 20-day adult    27 ovary, virgin 4-day female    89 ovary, mated 4-day female    99 testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    149 central nervous system, larvae L3    192 central nervous system, pupae P8    74 head, virgin 1-day female    39 head, virgin 4-day female    48 head, virgin 20-day female    30 head, mated 1-day female    39 head, mated 4-day female    43 head, mated 20-day female    31 head, mated 1-day male    53 head, mated 4-day male    62 head, mated 20-day male    72 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    44 digestive system, 1-day adult    27 digestive system, 4-day adult    48 digestive system, 20-day adult    42 fat body, larvae L3 wandering    26 fat body, white prepupae    43 fat body, pupae P8    70 carcass, larvae L3 wandering    128 carcass, 1-day adult    22 carcass, 4-day adult    36 carcass, 20-day adult    27 ovary, virgin 4-day female    89 ovary, mated 4-day female    99 testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    149 central nervous system, larvae L3    192 central nervous system, pupae P8    74 head, virgin 1-day female    39 head, virgin 4-day female    48 head, virgin 20-day female    30 head, mated 1-day female    39 head, mated 4-day female    43 head, mated 20-day female    31 head, mated 1-day male    53 head, mated 4-day male    62 head, mated 20-day male    72 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    44 digestive system, 1-day adult    27 digestive system, 4-day adult    48 digestive system, 20-day adult    42 fat body, larvae L3 wandering    26 fat body, white prepupae    43 fat body, pupae P8    70 carcass, larvae L3 wandering    128 carcass, 1-day adult    22 carcass, 4-day adult    36 carcass, 20-day adult    27 ovary, virgin 4-day female    89 ovary, mated 4-day female    99 testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (149) central nervous system, larvae L3  (192) central nervous system, pupae P8  (74) head, virgin 1-day female  (39) head, virgin 4-day female  (48) head, virgin 20-day female  30 head, mated 1-day female  (39) head, mated 4-day female  (43) head, mated 20-day female  31 head, mated 1-day male  (53) head, mated 4-day male  (62) head, mated 20-day male  (72) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (35) digestive system, larvae L3 wandering  (44) digestive system, 1-day adult  27 digestive system, 4-day adult  (48) digestive system, 20-day adult  (42) fat body, larvae L3 wandering  26 fat body, white prepupae  (43) fat body, pupae P8  (70) carcass, larvae L3 wandering  (128) carcass, 1-day adult    22 carcass, 4-day adult  (36) carcass, 20-day adult  27 ovary, virgin 4-day female  (89) ovary, mated 4-day female  (99) testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (149) central nervous system, larvae L3  (192) central nervous system, pupae P8    74 head, virgin 1-day female    39 head, virgin 4-day female    48 head, virgin 20-day female    30 head, mated 1-day female    39 head, mated 4-day female    43 head, mated 20-day female    31 head, mated 1-day male    53 head, mated 4-day male    62 head, mated 20-day male    72 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    44 digestive system, 1-day adult    27 digestive system, 4-day adult    48 digestive system, 20-day adult    42 fat body, larvae L3 wandering    26 fat body, white prepupae    43 fat body, pupae P8    70 carcass, larvae L3 wandering  128 carcass, 1-day adult    22 carcass, 4-day adult    36 carcass, 20-day adult    27 ovary, virgin 4-day female    89 ovary, mated 4-day female    99 testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    149 central nervous system, larvae L3    192 central nervous system, pupae P8    74 head, virgin 1-day female    39 head, virgin 4-day female    48 head, virgin 20-day female    30 head, mated 1-day female    39 head, mated 4-day female    43 head, mated 20-day female    31 head, mated 1-day male    53 head, mated 4-day male    62 head, mated 20-day male    72 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    35 digestive system, larvae L3 wandering    44 digestive system, 1-day adult    27 digestive system, 4-day adult    48 digestive system, 20-day adult    42 fat body, larvae L3 wandering    26 fat body, white prepupae    43 fat body, pupae P8    70 carcass, larvae L3 wandering    128 carcass, 1-day adult    22 carcass, 4-day adult    36 carcass, 20-day adult    27 ovary, virgin 4-day female    89 ovary, mated 4-day female    99 testis, mated 4-day male    14 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    158 embryo 02-04hr    223 embryo 04-06hr    206 embryo 06-08hr    271 embryo 08-10hr    220 embryo 10-12hr    117 embryo 12-14hr    89 embryo 14-16hr    176 embryo 16-18hr    84 embryo 18-20hr    48 embryo 20-22hr    84 embryo 22-24hr    52 larva L1    97 larva L2    54 larva L3 12hr old    53 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    56 white prepupae new    60 white prepupae 12hr    63 white prepupae 24hr    92 pupae 2d postWPP    44 pupae 3d postWPP    21 pupae 4d postWPP    38 adult male 01day    25 adult male 05day    45 adult male 30day    53 adult female 01day    74 adult female 05day    86 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (158) embryo 02-04hr  (223) embryo 04-06hr  (206) embryo 06-08hr  (271) embryo 08-10hr  (220) embryo 10-12hr  (117) embryo 12-14hr  (89) embryo 14-16hr  (176) embryo 16-18hr  (84) embryo 18-20hr  (48) embryo 20-22hr  (84) embryo 22-24hr  (52) larva L1  (97) larva L2  (54) larva L3 12hr old  (53) larva L3 puffstage 1-2  (38) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9  (56) white prepupae new  (60) white prepupae 12hr  (63) white prepupae 24hr  (92) pupae 2d postWPP  (44) pupae 3d postWPP    21 pupae 4d postWPP  (38) adult male 01day    25 adult male 05day  (45) adult male 30day  (53) adult female 01day  (74) adult female 05day  (86) adult female 30day  (94) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (158) embryo 02-04hr  (223) embryo 04-06hr  (206) embryo 06-08hr  (271) embryo 08-10hr  (220) embryo 10-12hr  (117) embryo 12-14hr    89 embryo 14-16hr  (176) embryo 16-18hr    84 embryo 18-20hr    48 embryo 20-22hr    84 embryo 22-24hr    52 larva L1    97 larva L2    54 larva L3 12hr old    53 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    56 white prepupae new    60 white prepupae 12hr    63 white prepupae 24hr    92 pupae 2d postWPP    44 pupae 3d postWPP    21 pupae 4d postWPP    38 adult male 01day    25 adult male 05day    45 adult male 30day    53 adult female 01day    74 adult female 05day    86 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    158 embryo 02-04hr    223 embryo 04-06hr    206 embryo 06-08hr    271 embryo 08-10hr    220 embryo 10-12hr    117 embryo 12-14hr    89 embryo 14-16hr    176 embryo 16-18hr    84 embryo 18-20hr    48 embryo 20-22hr    84 embryo 22-24hr    52 larva L1    97 larva L2    54 larva L3 12hr old    53 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    56 white prepupae new    60 white prepupae 12hr    63 white prepupae 24hr    92 pupae 2d postWPP    44 pupae 3d postWPP    21 pupae 4d postWPP    38 adult male 01day    25 adult male 05day    45 adult male 30day    53 adult female 01day    74 adult female 05day    86 adult female 30day    94 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    158 embryo 02-04hr    223 embryo 04-06hr    206 embryo 06-08hr    271 embryo 08-10hr    220 embryo 10-12hr    117 embryo 12-14hr    89 embryo 14-16hr    176 embryo 16-18hr    84 embryo 18-20hr    48 embryo 20-22hr    84 embryo 22-24hr    52 larva L1    97 larva L2    54 larva L3 12hr old    53 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    56 white prepupae new    60 white prepupae 12hr    63 white prepupae 24hr    92 pupae 2d postWPP    44 pupae 3d postWPP    21 pupae 4d postWPP    38 adult male 01day    25 adult male 05day    45 adult male 30day    53 adult female 01day    74 adult female 05day    86 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (158) embryo 02-04hr  (223) embryo 04-06hr  (206) embryo 06-08hr  (271) embryo 08-10hr  (220) embryo 10-12hr  (117) embryo 12-14hr  (89) embryo 14-16hr  (176) embryo 16-18hr  (84) embryo 18-20hr  (48) embryo 20-22hr  (84) embryo 22-24hr  (52) larva L1  (97) larva L2  (54) larva L3 12hr old  (53) larva L3 puffstage 1-2  (38) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9  (56) white prepupae new  (60) white prepupae 12hr  (63) white prepupae 24hr  (92) pupae 2d postWPP  (44) pupae 3d postWPP    21 pupae 4d postWPP  (38) adult male 01day    25 adult male 05day  (45) adult male 30day  (53) adult female 01day  (74) adult female 05day  (86) adult female 30day  (94) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (158) embryo 02-04hr  (223) embryo 04-06hr  (206) embryo 06-08hr  (271) embryo 08-10hr  (220) embryo 10-12hr  117 embryo 12-14hr    89 embryo 14-16hr  (176) embryo 16-18hr    84 embryo 18-20hr    48 embryo 20-22hr    84 embryo 22-24hr    52 larva L1    97 larva L2    54 larva L3 12hr old    53 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    56 white prepupae new    60 white prepupae 12hr    63 white prepupae 24hr    92 pupae 2d postWPP    44 pupae 3d postWPP    21 pupae 4d postWPP    38 adult male 01day    25 adult male 05day    45 adult male 30day    53 adult female 01day    74 adult female 05day    86 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    158 embryo 02-04hr    223 embryo 04-06hr    206 embryo 06-08hr    271 embryo 08-10hr    220 embryo 10-12hr    117 embryo 12-14hr    89 embryo 14-16hr    176 embryo 16-18hr    84 embryo 18-20hr    48 embryo 20-22hr    84 embryo 22-24hr    52 larva L1    97 larva L2    54 larva L3 12hr old    53 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    56 white prepupae new    60 white prepupae 12hr    63 white prepupae 24hr    92 pupae 2d postWPP    44 pupae 3d postWPP    21 pupae 4d postWPP    38 adult male 01day    25 adult male 05day    45 adult male 30day    53 adult female 01day    74 adult female 05day    86 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    183 Schneider line 2 Sg4    169 embryonic 1182-4H    191 embryonic GM2    97 embryonic Kc167    63 embryonic S1    179 embryonic S3    210 leg disc CME L1    168 wing disc CME-W2    159 wing disc ML-DmD8    190 wing disc ML-DmD9    217 wing disc ML-DmD16-c3    200 wing disc ML-DmD21    301 wing disc ML-DmD32    206 haltere disc ML-DmD17-c3    128 eye-antennal disc ML-DmD11    176 antennal disc ML-DmD20-c5    169 mixed discs ML-DmD4-c1    190 CNS ML-DmBG1-c1    230 CNS ML-DmBG2-c2    134 tumorous blood cells mbn2    181 ovary fGS/OSS    150 ovary OSC    118 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (183) Schneider line 2 Sg4  (169) embryonic 1182-4H  (191) embryonic GM2  (97) embryonic Kc167  (63) embryonic S1  (179) embryonic S3  (210) leg disc CME L1  (168) wing disc CME-W2  (159) wing disc ML-DmD8  (190) wing disc ML-DmD9  (217) wing disc ML-DmD16-c3  (200) wing disc ML-DmD21  (301) wing disc ML-DmD32  (206) haltere disc ML-DmD17-c3  (128) eye-antennal disc ML-DmD11  (176) antennal disc ML-DmD20-c5  (169) mixed discs ML-DmD4-c1  (190) CNS ML-DmBG1-c1  (230) CNS ML-DmBG2-c2  (134) tumorous blood cells mbn2  (181) ovary fGS/OSS  (150) ovary OSC  (118) ovary OSS  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (183) Schneider line 2 Sg4  (169) embryonic 1182-4H  (191) embryonic GM2    97 embryonic Kc167    63 embryonic S1  (179) embryonic S3  (210) leg disc CME L1  (168) wing disc CME-W2  (159) wing disc ML-DmD8  (190) wing disc ML-DmD9  (217) wing disc ML-DmD16-c3  (200) wing disc ML-DmD21  (301) wing disc ML-DmD32  (206) haltere disc ML-DmD17-c3  (128) eye-antennal disc ML-DmD11  (176) antennal disc ML-DmD20-c5  (169) mixed discs ML-DmD4-c1  (190) CNS ML-DmBG1-c1  (230) CNS ML-DmBG2-c2  (134) tumorous blood cells mbn2  (181) ovary fGS/OSS  (150) ovary OSC  (118) ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    183 Schneider line 2 Sg4    169 embryonic 1182-4H    191 embryonic GM2    97 embryonic Kc167    63 embryonic S1    179 embryonic S3    210 leg disc CME L1    168 wing disc CME-W2    159 wing disc ML-DmD8    190 wing disc ML-DmD9    217 wing disc ML-DmD16-c3    200 wing disc ML-DmD21    301 wing disc ML-DmD32    206 haltere disc ML-DmD17-c3    128 eye-antennal disc ML-DmD11    176 antennal disc ML-DmD20-c5    169 mixed discs ML-DmD4-c1    190 CNS ML-DmBG1-c1    230 CNS ML-DmBG2-c2    134 tumorous blood cells mbn2    181 ovary fGS/OSS    150 ovary OSC    118 ovary OSS    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    183 Schneider line 2 Sg4    169 embryonic 1182-4H    191 embryonic GM2    97 embryonic Kc167    63 embryonic S1    179 embryonic S3    210 leg disc CME L1    168 wing disc CME-W2    159 wing disc ML-DmD8    190 wing disc ML-DmD9    217 wing disc ML-DmD16-c3    200 wing disc ML-DmD21    301 wing disc ML-DmD32    206 haltere disc ML-DmD17-c3    128 eye-antennal disc ML-DmD11    176 antennal disc ML-DmD20-c5    169 mixed discs ML-DmD4-c1    190 CNS ML-DmBG1-c1    230 CNS ML-DmBG2-c2    134 tumorous blood cells mbn2    181 ovary fGS/OSS    150 ovary OSC    118 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (183) Schneider line 2 Sg4  (169) embryonic 1182-4H  (191) embryonic GM2  (97) embryonic Kc167  (63) embryonic S1  (179) embryonic S3  (210) leg disc CME L1  (168) wing disc CME-W2  (159) wing disc ML-DmD8  (190) wing disc ML-DmD9  (217) wing disc ML-DmD16-c3  (200) wing disc ML-DmD21  (301) wing disc ML-DmD32  (206) haltere disc ML-DmD17-c3  (128) eye-antennal disc ML-DmD11  (176) antennal disc ML-DmD20-c5  (169) mixed discs ML-DmD4-c1  (190) CNS ML-DmBG1-c1  (230) CNS ML-DmBG2-c2  (134) tumorous blood cells mbn2  (181) ovary fGS/OSS  (150) ovary OSC  (118) ovary OSS  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (183) Schneider line 2 Sg4  (169) embryonic 1182-4H  (191) embryonic GM2    97 embryonic Kc167    63 embryonic S1  (179) embryonic S3  (210) leg disc CME L1  (168) wing disc CME-W2  (159) wing disc ML-DmD8  (190) wing disc ML-DmD9  (217) wing disc ML-DmD16-c3  (200) wing disc ML-DmD21  (301) wing disc ML-DmD32  (206) haltere disc ML-DmD17-c3  128 eye-antennal disc ML-DmD11  (176) antennal disc ML-DmD20-c5  (169) mixed discs ML-DmD4-c1  (190) CNS ML-DmBG1-c1  (230) CNS ML-DmBG2-c2  134 tumorous blood cells mbn2  (181) ovary fGS/OSS  (150) ovary OSC  118 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    183 Schneider line 2 Sg4    169 embryonic 1182-4H    191 embryonic GM2    97 embryonic Kc167    63 embryonic S1    179 embryonic S3    210 leg disc CME L1    168 wing disc CME-W2    159 wing disc ML-DmD8    190 wing disc ML-DmD9    217 wing disc ML-DmD16-c3    200 wing disc ML-DmD21    301 wing disc ML-DmD32    206 haltere disc ML-DmD17-c3    128 eye-antennal disc ML-DmD11    176 antennal disc ML-DmD20-c5    169 mixed discs ML-DmD4-c1    190 CNS ML-DmBG1-c1    230 CNS ML-DmBG2-c2    134 tumorous blood cells mbn2    181 ovary fGS/OSS    150 ovary OSC    118 ovary OSS    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    67 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    89 Copper 0.5 mM 12 hrs, larvae L3    90 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    95 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    43 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    87 Caffeine 25 mg/ml 48 hrs, 4-day adult    66 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    82 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (83) cold shock, 4-day adult  (67) heat shock, 4-day adult  (75) Cadmium 50 mM 6 hrs, larvae L3  (47) Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult  (62) Cadmium 100 mM 48 hrs, 4-day adult  (89) Copper 0.5 mM 12 hrs, larvae L3  (90) Copper 15 mM 48 hrs, 4-day adult  (33) Zinc 5 mM 12 hrs, larvae L3  (61) Zinc 4.5 mM 48 hrs, 4-day adult  (43) Ethanol 2.5% 3 hrs, larvae L3  (95) Ethanol 5% 3 hrs, larvae L3  (32) Ethanol 10% 3 hrs, larvae L3  (43) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (87) Caffeine 25 mg/ml 48 hrs, 4-day adult  (66) Paraquat 5 mM 48 hrs, 4-day adult  (83) Paraquat 10 mM 48 hrs, 4-day adult  (82) Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    67 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    89 Copper 0.5 mM 12 hrs, larvae L3    90 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    95 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    43 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    87 Caffeine 25 mg/ml 48 hrs, 4-day adult    66 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    82 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    67 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    89 Copper 0.5 mM 12 hrs, larvae L3    90 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    95 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    43 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    87 Caffeine 25 mg/ml 48 hrs, 4-day adult    66 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    82 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    67 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    89 Copper 0.5 mM 12 hrs, larvae L3    90 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    95 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    43 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    87 Caffeine 25 mg/ml 48 hrs, 4-day adult    66 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    82 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (83) cold shock, 4-day adult  (67) heat shock, 4-day adult  (75) Cadmium 50 mM 6 hrs, larvae L3  (47) Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult  (62) Cadmium 100 mM 48 hrs, 4-day adult  (89) Copper 0.5 mM 12 hrs, larvae L3  (90) Copper 15 mM 48 hrs, 4-day adult  (33) Zinc 5 mM 12 hrs, larvae L3  (61) Zinc 4.5 mM 48 hrs, 4-day adult  (43) Ethanol 2.5% 3 hrs, larvae L3  (95) Ethanol 5% 3 hrs, larvae L3  32 Ethanol 10% 3 hrs, larvae L3  (43) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (87) Caffeine 25 mg/ml 48 hrs, 4-day adult  (66) Paraquat 5 mM 48 hrs, 4-day adult  (83) Paraquat 10 mM 48 hrs, 4-day adult  (82) Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    67 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    89 Copper 0.5 mM 12 hrs, larvae L3    90 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    95 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    43 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    87 Caffeine 25 mg/ml 48 hrs, 4-day adult    66 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    82 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    83 cold shock, 4-day adult    67 heat shock, 4-day adult    75 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    89 Copper 0.5 mM 12 hrs, larvae L3    90 Copper 15 mM 48 hrs, 4-day adult    33 Zinc 5 mM 12 hrs, larvae L3    61 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    95 Ethanol 5% 3 hrs, larvae L3    32 Ethanol 10% 3 hrs, larvae L3    43 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    87 Caffeine 25 mg/ml 48 hrs, 4-day adult    66 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    82 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD22761 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011571 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3606-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU cazScer\UAS.T:Ivir\HA1 lethal | heat sensitive, with Scer\GAL4D42 cazScer\UAS.T:Ivir\HA1 lethal | pupal stage, with Scer\GAL4D42 cazScer\UAS.T:Ivir\HA1 lethal | pupal stage, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 lethal | pupal stage | heat sensitive, with Scer\GAL4Act5C.PI cazdsRNA.1-167.Scer\UAS partially lethal - majority die | heat sensitive, with Scer\GAL4Act5C.PU cazKK107486 partially lethal - majority die | heat sensitive, with Scer\GAL4D42 cazKK107486 partially lethal - majority die | heat sensitive, with Scer\GAL4elav.PU cazKK107486 cazScer\UAS.T:Ivir\HA1 viable, with Scer\GAL4Act5C.PI cazdsRNA.180-346.Scer\UAS Other Phenotypes Allele gravitaxis defective | adult stage, with Scer\GAL4elav.PLu cazdsRNA.1-167.Scer\UAS cazKK107486 locomotor behavior defective | third instar larval stage, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 neuroanatomy defective, with Scer\GAL4Rapgap1-OK6 cazScer\UAS.x10.T:Zzzz\FLAG neuroanatomy defective | adult stage | conditional, with Scer\GAL4GMR.PF cazScer\UAS.T:Ivir\HA1 neuroanatomy defective | third instar larval stage, with Scer\GAL4elav.PLu cazdsRNA.1-167.Scer\UAS cazKK107486 neuroanatomy defective | third instar larval stage, with Scer\GAL4VGlut-OK371 cazKK107486 cazScer\UAS.T:Ivir\HA1 visible, with Scer\GAL4Bx-MS1096 cazScer\UAS.T:Ivir\HA1 visible | adult stage, with Scer\GAL4Bx-MS1096 cazKK107486 visible | adult stage | conditional, with Scer\GAL4GMR.PF cazScer\UAS.T:Ivir\HA1 visible | larval stage, with Scer\GAL4GMR.PF cazKK107486 wild-type cazrv1 Phenotype manifest in Allele A1-7 ventral longitudinal muscle 3, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 A1-7 ventral longitudinal muscle 4, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 abdominal segment motor neuron | third instar larval stage, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 cazKK107486 embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav.PLu cazKK107486 cazdsRNA.1-167.Scer\UAS embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Rapgap1-OK6 cazScer\UAS.x10.T:Zzzz\FLAG embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 eye | conditional, with Scer\GAL4GMR.PF cazScer\UAS.T:Ivir\HA1 eye disc, with Scer\GAL4GMR.PF cazKK107486 NMJ bouton | third instar larval stage, with Scer\GAL4elav.PLu cazKK107486 cazdsRNA.1-167.Scer\UAS NMJ bouton | third instar larval stage, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 ommatidium, with Scer\GAL4GMR.PF cazKK107486 ommatidium | conditional, with Scer\GAL4GMR.PF cazScer\UAS.T:Ivir\HA1 ventral nerve cord | third instar larval stage, with Scer\GAL4VGlut-OK371 cazScer\UAS.T:Ivir\HA1 cazKK107486 wing, with Scer\GAL4Bx-MS1096 cazScer\UAS.T:Ivir\HA1 cazKK107486
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of caz Class Mutagen Stocks Known lesion cazEP1564 P-element activity 1 Yes caz383 P-element activity 0 Yes cazrv1 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of caz Class Mutagen Stocks Known lesion cazHMS00156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cazHMS00790 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cazKK107486 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cazdsRNA.1-167.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes cazdsRNA.180-346.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes cazGD4173 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cazP398L.10x.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes cazR395G.10x.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes cazScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cazScer\UAS.x10.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cazT:Zzzz\FLAG in vitro construct - genomic fragment in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)383 (Wang et al., 2011) Df(1)BSC759 (Xia et al., 2012)
Partially disrupted in	Df(1)383 (Wang et al., 2011)
Not disrupted in	Df(1)ED7355 (Xia et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{10xUAS-caz.FLAG} NA P{10xUAS-caz.P398L.FLAG} NA P{10xUAS-caz.R395G.FLAG} NA P{GD4173} NA P{KK107486} NA P{TRiP.HMS00156} NA P{TRiP.HMS00790} NA P{UAS-caz.HA} NA P{UAS-caz.IR.1-167} NA P{UAS-caz.IR.180-346} NA characterization construct P{caz.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cazEP1564 NA P{Mae-UAS.6.11}B0176B0176 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult locomotory behavior inferred from mutant phenotype (Wang et al., 2011, Xia et al., 2012) compound eye development inferred from mutant phenotype (Xia et al., 2012) larval locomotory behavior inferred from mutant phenotype (Xia et al., 2012) positive regulation of motor neuron apoptotic process inferred from mutant phenotype (Xia et al., 2012)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleoplasm inferred from direct assay (Sasayama et al., 2012) nucleus inferred from direct assay (Immanuel et al., 1995, Wang et al., 2011) colocalizes_with transcriptionally active chromatin inferred from direct assay (Immanuel et al., 1995)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR001876 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071013 (Herold et al., 2009) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with human TAF12 (Aoyagi and Wassarman, 2000)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) transcription factor TFIID complex inferred from sequence or structural similarity with human TAF12 (Aoyagi and Wassarman, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
caz - TBPH anti tag coimmunoprecipitation, anti tag western blot (Wang et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions caz allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0011571 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32587
Orthologs
OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W9JQD Dipteran inclusive ortholog search EOG670TSK Insect inclusive ortholog search EOG65MM2S Arthropod inclusive ortholog search EOG6DZ0BK Metazoa inclusive ortholog search EOG6ZKXH4
Orthologs in Drosophila Species (EOG6W9JQD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\caz     Drosophila simulans   Dsim\GD17272 Y   Drosophila sechellia   Dsec\GM13418 Y   Drosophila erecta   Dere\GG17948 Y   Drosophila ananassae   Dana\GF19034 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22827 Y   Drosophila persimilis   Dper\GL21338 Y   Drosophila willistoni   Dwil\GK25719 Y   Drosophila virilis   Dvir\GJ18507 Y   Drosophila mojavensis   Dmoj\GI11213 Y   Drosophila grimshawi   Dgri\GH12560 Y
Orthologs in non-Drosophila Dipterans (EOG670TSK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005394   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005382   Anopheles gambiae Malaria mosquito  Agam\AGAP001645   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006342
Orthologs in non-Dipteran Insects (EOG65MM2S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44991   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012235   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27178   Atta cephalotes Leafcutter ant  Acep\ACEP20301   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21206   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18228   Linepithema humile Argentine ant  Lhum\LH15898   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18945   Solenopsis invicta Red fire ant  Sinv\SINV14664   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009286   Bombyx mori Silkmoth  Bmor\BGIBMGA006796   Pediculus humanus Human body louse  Phum\PHUM175000   Tribolium castaneum Red flour beetle  Tcas\TC011980   Tribolium castaneum Red flour beetle  Tcas\Nplp4
Orthologs in non-Insect Arthropods (EOG6DZ0BK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_238350   Ixodes scapularis Deer tick  Isca\ISCW015311
Orthologs in non-Arthropod Metazoa (EOG6ZKXH4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\fust-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005676gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004836gn   Danio rerio Zebrafish  Drer\ENSDARG00000020258   Danio rerio Zebrafish  Drer\zgc:158363   Danio rerio Zebrafish  Drer\ewsr1b   Danio rerio Zebrafish  Drer\fus   Xenopus tropicalis Western clawed frog  Xtro\ewsr1   Xenopus tropicalis Western clawed frog  Xtro\fus   Xenopus tropicalis Western clawed frog  Xtro\taf15   Gallus gallus Domestic chicken  Ggal\EWSR1   Gallus gallus Domestic chicken  Ggal\TAF15   Mus musculus House mouse  Mmus\Ewsr1   Mus musculus House mouse  Mmus\Taf15   Rattus norvegicus Norway rat  Rnor\RGD1566093   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038121   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022418   Rattus norvegicus Norway rat  Rnor\Fus   Rattus norvegicus Norway rat  Rnor\Taf15   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024836   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008655   Rattus norvegicus Norway rat  Rnor\Ewsr1   Homo sapiens Human  Hsap\FUS   Homo sapiens Human  Hsap\EWSR1   Homo sapiens Human  Hsap\TAF15
Human Orthologs (3)
Gene OMIM HGNC Hsap\FUS     Hsap\EWSR1     Hsap\TAF15
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17272 Drosophila sechellia Dsec\GM13418 Drosophila erecta Dere\GG17948 Drosophila yakuba Dyak\GE17258 Drosophila ananassae Dana\GF19034 Drosophila pseudoobscura pseudoobscura Dpse\GA22827 Drosophila persimilis Dper\GL21338 Drosophila willistoni Dwil\GK25719 Drosophila virilis Dvir\GJ18507 Drosophila mojavensis Dmoj\GI11213 Drosophila grimshawi Dgri\GH12560
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17010 w1118 P{EP}cazEP1564 32990 y1 sc* v1; P{TRiP.HMS00790}attP2 34839 y1 sc* v1; P{TRiP.HMS00156}attP2
VDRC	v100291 P{KK107486}VIE-260B
Genomic Clones ( 2 )
	BACR06P10 BACR13G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09207 LD22761
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10644 GH12030 GM03708 GM08888 GM19081 LD02256 LD04561 LD06336 LD09020 LD12830 LD16412 LD27742 LD33502 LD46290 LD47866 LD47879 LD47883 LP20832 LP21988 RE05486 RE06215 RE25612 RE66702 RE70738 RE71292 RE71693 RE73469 RE73516 SD06591 SD22507
Other clones	7621 30103 118414 120144.1 214283.43 CK01.81B.C5 CK01.110C.E1 Dmel_dig_007676_0584_2543 Dmel_dig_012623_0655_1898 EK062811 EK100913 EK125515 EK237629 EK251755 EP01006 FGM222G11 IP07353 IP07453
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011571 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32587
Antibody Information
	polyclonal (Sasayama et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: caz BcDNA:GM09207 (FlyBase, 1996-)
Additional comments	Source for merge of caz BcDNA:GM09207 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	caz has been cloned and sequenced, and its expression pattern has been analysed. (Immanuel et al., 1995) caz gene product contains a glycine rich C-terminal domain, but only one RNA recognition motif (RRM) located in the central portion. Intron and exon borders of full length cDNA and genomic clones have been determined and the predicted protein has 403 amino acids and is 48.4kD. UV crosslinking experiments demonstrate general RNA binding activity for the full length protein and the RRM domain. (Stolow and Haynes, 1994) Isolated from a pupal cDNA library, using a fragment of the fs(1)h coding region containing "pen" repetitive sequences (GGN, where N is any nucleotide) as the probe. (Haynes et al., 1987)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078641 NM_167493 NM_001272672 NM_001272673 RefSeq (Proteins) • NP_523365 NP_727946 NP_001259601 NP_001259602 DDBJ / EMBL / GenBank • AA697152 AA820124 AAA70425 AAA86955 AAC41563 AAF48578 AAM11116 AAN09389 AAO45231 AGB95443 AGB95444 AI455298 AW941337 AY094763 BT004875 L37083 M15765 U13178 Entrez Gene - A searchable database of RefSeq genes. • 32587 UniProtKB/Swiss-Prot • Q27294
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, RanBP2-type (IPR001876) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22761
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0011571 DRSC - Results from RNAi screens. • FBgn0011571 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011571 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3606-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011571 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32587 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32587 modMine - Data generated by the modENCODE project. • FBgn0011571
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	anon-Pen19   BcDNA:GM09207   cas (Robertson, 2001.1.8) caz (Legube et al., 2006, Wang et al., 2011, Hartmann et al., 2011, Herold et al., 2009, Zhou et al., 2008) Caz (Xia et al., 2012, Sasayama et al., 2012) CG3606 (Aoyagi and Wassarman, 2000, Grieder et al., 2007, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2010.12.1, Ni et al., 2011.7.19) EWSR1 (Couthouis et al., 2012) P19 (Stolow and Haynes, 1994, ) p19 (Haynes et al., 1987) pen19   Pen19   SARFH (Immanuel, 1994.8.8, Immanuel et al., 1995) Sarfh   TFIID (Butler and Kadonaga, 2002)
Name Synonym	cabeza (Stolow, 1994, Wang et al., 2011) CABEZA (Minakhina et al., 2003) Cabeza (Xia et al., 2012) Sarcoma-associated RNA-binding fly homolog (Immanuel et al., 1995, )
Secondary FlyBase IDs
	FBgn0003059 FBgn0011830 FBgn0062479
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Thesis  ( 1 )
Recent research papers ( 8 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Couthouis et al., 2012, Hum. Mol. Genet. 21(13): 2899--2911 Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. [FBrf0218546] Sasayama et al., 2012, PLoS ONE 7(6): e39483 Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches. [FBrf0218682] Wang et al., 2012, PLoS ONE 7(7): e42102 A modular toolset for recombination transgenesis and neurogenetic analysis of Drosophila. [FBrf0219026] Xia et al., 2012, Mol. Neurodegener. 7: 10 Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. [FBrf0218020] Hartmann et al., 2011, RNA 17(3): 453--468 Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster. [FBrf0212988] Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Wang et al., 2011, J. Clin. Invest. 121(10): 4118--4126 The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. [FBrf0216240] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...