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Gene Dmel\caz

General Information
Symbol	Dmel\caz	Species	D. melanogaster
Name	cabeza	Annotation symbol	CG3606
Feature type	protein_coding_gene	FlyBase ID	FBgn0011571
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	SARFH, P19
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	14B8-14B9	Sequence location	X:16,182,879..16,187,553 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cabeza is referred to in FlyBase by the symbol Dmel\caz (CG3606, FBgn0011571). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. Based on sequence similarity, it is predicted to be involved in the biological process: transcription initiation from RNA polymerase II promoter. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain; Zinc finger, RanBP2-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult Malpighian tubules, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634362_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of caz. Gene sequence location is X:16182879..16187553.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Wang et al., 2011, J. clin. Invest. 121(10): 4118--4126 Sequence features BKN27486 HFA20317 Controlled Vocabulary Terms transcriptionally active chromatin
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14B8-14B9   Limits computationally determined from genome sequence between P{EP}kat80EP620&P{EP}cazEP1564 and P{EP}Cyp1EP1073&P{EP}Dsp1EP355
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14-14     (Immanuel, 1994.8.8) 14B-14B   (determined by in situ hybridisation)   (Immanuel et al., 1995)
Experimentally Determined Recombination Data
Location	1- (Immanuel, 1994.8.8)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\caz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) caz-RB FBtr0074217  NM_078641   1630   399
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein caz-PB   FBpp0073996   38.8   399   9.72     NP_523365   AAN09389
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, RanBP2-type (IPR001876) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201394   AA202136   AA263238   AA390745   AA392581   AA441465   AA697002   AA697152   AA802002   AA820124   AA949010   AA979197   AE014298 AAN09389   AI114013   AI134540   AI455298   AI534083   AI546184   AI546318   AI546328   AI546331   AW941337   AY094763 AAM11116   BI165566   BI166173   BI228161   BI352391   BI483767   BI487216   BI577590   BI577923   BI579440   BI579473   BI639817   BP553150   BP553151   BT004875 AAO45231   CK661373   CK662055   CO270876   CO277568   CO286426   CO306670   CO314736   CO339163   EC070966   EC076859   EC076981   EC082342   EC207476   EC209770   EC220651   EC256390   EL877411   EL877486   EV576710   EV585175   L37083 AAC41563   M15765 AAA70425   U13178 AAA86955
UniProtKB/Swiss-Prot	Q27294
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011571    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011571 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011571 expression level Developmental Stage   Expression Level embryo 00-02hr    12279 embryo 02-04hr    17315 embryo 04-06hr    15984 embryo 06-08hr    20992 embryo 08-10hr    17075 embryo 10-12hr    9110 embryo 12-14hr    6879 embryo 14-16hr    13673 embryo 16-18hr    6547 embryo 18-20hr    3740 embryo 20-22hr    6545 embryo 22-24hr    4056 larva L1    7556 larva L2    4152 larva L3 12hr old    4122 larva L3 puffstage 1-2    2969 larva L3 puffstage 3-6    5110 larva L3 puffstage 7-9    4324 white prepupae new    4676 white prepupae 12hr    4869 white prepupae 24hr    7134 pupae 2d postWPP    3435 pupae 3d postWPP    1647 pupae 4d postWPP    2920 adult male 01day    1907 adult male 05day    3497 adult male 30day    4126 adult female 01day    5773 adult female 05day    6694 adult female 30day    7296 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12279) embryo 02-04hr  (17315) embryo 04-06hr  (15984) embryo 06-08hr  (20992) embryo 08-10hr  (17075) embryo 10-12hr  (9110) embryo 12-14hr  (6879) embryo 14-16hr  (13673) embryo 16-18hr  (6547) embryo 18-20hr  (3740) embryo 20-22hr  (6545) embryo 22-24hr  (4056) larva L1  (7556) larva L2  (4152) larva L3 12hr old  (4122) larva L3 puffstage 1-2  (2969) larva L3 puffstage 3-6  (5110) larva L3 puffstage 7-9  (4324) white prepupae new  (4676) white prepupae 12hr  (4869) white prepupae 24hr  (7134) pupae 2d postWPP  (3435) pupae 3d postWPP  (1647) pupae 4d postWPP  (2920) adult male 01day  (1907) adult male 05day  (3497) adult male 30day  (4126) adult female 01day  (5773) adult female 05day  (6694) adult female 30day  (7296) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12279) embryo 02-04hr  (17315) embryo 04-06hr  (15984) embryo 06-08hr  (20992) embryo 08-10hr  (17075) embryo 10-12hr  (9110) embryo 12-14hr  (6879) embryo 14-16hr  (13673) embryo 16-18hr  (6547) embryo 18-20hr  (3740) embryo 20-22hr  (6545) embryo 22-24hr  (4056) larva L1  (7556) larva L2  (4152) larva L3 12hr old  (4122) larva L3 puffstage 1-2  (2969) larva L3 puffstage 3-6  (5110) larva L3 puffstage 7-9  (4324) white prepupae new  (4676) white prepupae 12hr  (4869) white prepupae 24hr  (7134) pupae 2d postWPP  (3435) pupae 3d postWPP  (1647) pupae 4d postWPP  (2920) adult male 01day  (1907) adult male 05day  (3497) adult male 30day  (4126) adult female 01day  (5773) adult female 05day  (6694) adult female 30day  (7296) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (12279) embryo 02-04hr  (17315) embryo 04-06hr  (15984) embryo 06-08hr  (20992) embryo 08-10hr  (17075) embryo 10-12hr    9110 embryo 12-14hr    6879 embryo 14-16hr  (13673) embryo 16-18hr    6547 embryo 18-20hr    3740 embryo 20-22hr    6545 embryo 22-24hr    4056 larva L1    7556 larva L2    4152 larva L3 12hr old    4122 larva L3 puffstage 1-2    2969 larva L3 puffstage 3-6    5110 larva L3 puffstage 7-9    4324 white prepupae new    4676 white prepupae 12hr    4869 white prepupae 24hr    7134 pupae 2d postWPP    3435 pupae 3d postWPP    1647 pupae 4d postWPP    2920 adult male 01day    1907 adult male 05day    3497 adult male 30day    4126 adult female 01day    5773 adult female 05day    6694 adult female 30day    7296 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12279 embryo 02-04hr    17315 embryo 04-06hr    15984 embryo 06-08hr    20992 embryo 08-10hr    17075 embryo 10-12hr    9110 embryo 12-14hr    6879 embryo 14-16hr    13673 embryo 16-18hr    6547 embryo 18-20hr    3740 embryo 20-22hr    6545 embryo 22-24hr    4056 larva L1    7556 larva L2    4152 larva L3 12hr old    4122 larva L3 puffstage 1-2    2969 larva L3 puffstage 3-6    5110 larva L3 puffstage 7-9    4324 white prepupae new    4676 white prepupae 12hr    4869 white prepupae 24hr    7134 pupae 2d postWPP    3435 pupae 3d postWPP    1647 pupae 4d postWPP    2920 adult male 01day    1907 adult male 05day    3497 adult male 30day    4126 adult female 01day    5773 adult female 05day    6694 adult female 30day    7296 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011571 expression level Developmental Stage   Expression Level embryo 00-02hr    12279 embryo 02-04hr    17315 embryo 04-06hr    15984 embryo 06-08hr    20992 embryo 08-10hr    17075 embryo 10-12hr    9110 embryo 12-14hr    6879 embryo 14-16hr    13673 embryo 16-18hr    6547 embryo 18-20hr    3740 embryo 20-22hr    6545 embryo 22-24hr    4056 larva L1    7556 larva L2    4152 larva L3 12hr old    4122 larva L3 puffstage 1-2    2969 larva L3 puffstage 3-6    5110 larva L3 puffstage 7-9    4324 white prepupae new    4676 white prepupae 12hr    4869 white prepupae 24hr    7134 pupae 2d postWPP    3435 pupae 3d postWPP    1647 pupae 4d postWPP    2920 adult male 01day    1907 adult male 05day    3497 adult male 30day    4126 adult female 01day    5773 adult female 05day    6694 adult female 30day    7296 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12279) embryo 02-04hr  (17315) embryo 04-06hr  (15984) embryo 06-08hr  (20992) embryo 08-10hr  (17075) embryo 10-12hr  (9110) embryo 12-14hr  (6879) embryo 14-16hr  (13673) embryo 16-18hr  (6547) embryo 18-20hr  (3740) embryo 20-22hr  (6545) embryo 22-24hr  (4056) larva L1  (7556) larva L2  (4152) larva L3 12hr old  (4122) larva L3 puffstage 1-2  (2969) larva L3 puffstage 3-6  (5110) larva L3 puffstage 7-9  (4324) white prepupae new  (4676) white prepupae 12hr  (4869) white prepupae 24hr  (7134) pupae 2d postWPP  (3435) pupae 3d postWPP  (1647) pupae 4d postWPP  (2920) adult male 01day  (1907) adult male 05day  (3497) adult male 30day  (4126) adult female 01day  (5773) adult female 05day  (6694) adult female 30day  (7296) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12279) embryo 02-04hr  (17315) embryo 04-06hr  (15984) embryo 06-08hr  (20992) embryo 08-10hr  (17075) embryo 10-12hr  (9110) embryo 12-14hr  (6879) embryo 14-16hr  (13673) embryo 16-18hr  (6547) embryo 18-20hr  (3740) embryo 20-22hr  (6545) embryo 22-24hr  (4056) larva L1  (7556) larva L2  (4152) larva L3 12hr old  (4122) larva L3 puffstage 1-2  (2969) larva L3 puffstage 3-6  (5110) larva L3 puffstage 7-9  (4324) white prepupae new  (4676) white prepupae 12hr  (4869) white prepupae 24hr  (7134) pupae 2d postWPP  (3435) pupae 3d postWPP  1647 pupae 4d postWPP  (2920) adult male 01day  1907 adult male 05day  (3497) adult male 30day  (4126) adult female 01day  (5773) adult female 05day  (6694) adult female 30day  (7296) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  12279 embryo 02-04hr  17315 embryo 04-06hr  15984 embryo 06-08hr  (20992) embryo 08-10hr  17075 embryo 10-12hr    9110 embryo 12-14hr    6879 embryo 14-16hr  13673 embryo 16-18hr    6547 embryo 18-20hr    3740 embryo 20-22hr    6545 embryo 22-24hr    4056 larva L1    7556 larva L2    4152 larva L3 12hr old    4122 larva L3 puffstage 1-2    2969 larva L3 puffstage 3-6    5110 larva L3 puffstage 7-9    4324 white prepupae new    4676 white prepupae 12hr    4869 white prepupae 24hr    7134 pupae 2d postWPP    3435 pupae 3d postWPP    1647 pupae 4d postWPP    2920 adult male 01day    1907 adult male 05day    3497 adult male 30day    4126 adult female 01day    5773 adult female 05day    6694 adult female 30day    7296 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12279 embryo 02-04hr    17315 embryo 04-06hr    15984 embryo 06-08hr    20992 embryo 08-10hr    17075 embryo 10-12hr    9110 embryo 12-14hr    6879 embryo 14-16hr    13673 embryo 16-18hr    6547 embryo 18-20hr    3740 embryo 20-22hr    6545 embryo 22-24hr    4056 larva L1    7556 larva L2    4152 larva L3 12hr old    4122 larva L3 puffstage 1-2    2969 larva L3 puffstage 3-6    5110 larva L3 puffstage 7-9    4324 white prepupae new    4676 white prepupae 12hr    4869 white prepupae 24hr    7134 pupae 2d postWPP    3435 pupae 3d postWPP    1647 pupae 4d postWPP    2920 adult male 01day    1907 adult male 05day    3497 adult male 30day    4126 adult female 01day    5773 adult female 05day    6694 adult female 30day    7296 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011571    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011571 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult Malpighian tubules, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011571 expression level Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (894.725) Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea  (592.95) Larval Carcass    337.575 Adult Head    313.8 Adult Eye  (555.275) Adult Brain  (785) Adult Thoracic-Abdominal Ganglion  (607.4) Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules  (624.1) Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary  (724.1) Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011571 expression level Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (894.725) Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea  592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye  555.275 Adult Brain  785 Adult Thoracic-Abdominal Ganglion  607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules  624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary  724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    894.725 Larval Midgut    275.2 Larval Hindgut    329.9 Larval Malpighian Tubules    336.8 Larval Fat Body    335.8 Larval Salivary Gland    419.1 Larval Trachea    592.95 Larval Carcass    337.575 Adult Head    313.8 Adult Eye    555.275 Adult Brain    785 Adult Thoracic-Abdominal Ganglion    607.4 Adult Crop    281.6 Adult Midgut    296.6 Adult Hindgut    287.7 Adult Malpighian Tubules    624.1 Adult Fat Body    231.1 Adult Salivary Gland    297.3 Adult Heart    356.375 Adult VirginFemale Spermatheca    348 Adult InseminatedFemale Spermatheca    457.7 Adult Ovary    724.1 Adult Testis    147 Adult Male Accessory Gland    167.4 Adult Carcass    224.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    313.8   NA  Eye    555.275   NA  Brain    785   894.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    607.4   NA  Crop    281.6   275.2  Midgut    296.6   329.9  Hindgut    287.7   336.8  Malpighian Tubules    624.1   335.8  Fat Body    231.1   419.1  Salivary Gland    297.3   NA  Heart    356.375   592.95  Trachea    NA   NA  VirginFemale Spermatheca    348   NA  InseminatedFemale Spermatheca    457.7   NA  Ovary    724.1   NA  Testis    147   NA  Male Accessory Gland    167.4   337.575  Carcass    224.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011571 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3606-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of caz Class Mutagen Stocks Known lesion cazEP1564 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of caz Class Mutagen Stocks Known lesion cazHMS00156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cazHMS00790 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cazKK107486 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cazGD4173 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4173} NA P{KK107486} NA P{TRiP.HMS00156} NA P{TRiP.HMS00790} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cazEP1564 NA P{Mae-UAS.6.11}B0176B0176 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleus inferred from direct assay (Immanuel et al., 1995) colocalizes_with transcriptionally active chromatin inferred from direct assay (Immanuel et al., 1995)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR001876 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071013 (Herold et al., 2009) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with human TAF12 (Aoyagi and Wassarman, 2000)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) transcription factor TFIID complex inferred from sequence or structural similarity with human TAF12 (Aoyagi and Wassarman, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions caz allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0011571 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32587
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19034 Dere\GG17948 Dgri\GH12560 Dmoj\GI11213 Dper\GL21338 Dpse\GA22827 Dsec\GM13418 Dsim\GD17272 Dvir\GJ18507 Dwil\GK25719 Dyak\GE17258
Curated drosophilid orthologs	Dpse\GA17554
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005382-PA Aedes aegypti (mosquito) AGAP001645-PA Anopheles gambiae (mosquito) XP_624681.1 Apis mellifera (honey bee) XP_001948049.1 Acyrthosiphon pisum (pea aphid) At1g50300.1 Arabidopsis thaliana (wall cress) 118606 Branchiostoma floridae (lancelet) BGIBMGA006796-PA Bombyx mori (silk worm) ENSBTAP00000007571 Bos taurus (bovine) CN21497 Caenorhabditis brenneri (small nematode) CBP33968 Caenorhabditis briggsae (nematode) CE27099 Caenorhabditis elegans (worm) ENSCAFP00000024800 Canis familiaris (dog) JA04204 Caenorhabditis japonica (nematode) ENSCPOP00000008529 Cavia porcellus (guinea pig) RP47183 Caenorhabditis remanei (nematode) 222177 Capitella spl (polychaete worm) 238350 Daphnia pulex (daphnia) ENSDARP00000055339 Danio rerio (zebra fish) ENSECAP00000019904 Equus caballus (horse) ENSGACP00000019672 Gymnopilus aculeatus (mushroom) ENSGALP00000003199 Gallus gallus (chicken) 186994 Hypsipyla robusta (cedar shoot borer) ENSP00000254108 Homo sapiens (human) ISCW015311-PA Ixodes scapularis (deer tick) ENSMODP00000002300 Monodelphis domestica (gray opossum) ENSMMUP00000032452 Macaca mulatta (rhesus monkey) ENSMUSP00000101858 Mus musculus (house mouse) XP_001606397.1 Nasonia vitripennis (wasp) ENSOANP00000008923 Ornithorynchus anatinus (platypus) ENSORLP00000008429 Oryzias latipes (japanese killifish) ENSORLP00000014255 Oryzias latipes (japanese killifish) LOC_Os09g12800.1 Oryza sativa (asian rice) 164439 Physcomitrella patens (moss) ENSPPYP00000008259 Pongo pygmaeus (orangutan) 156131 Phytophthora sojae (root rot pathogen) 564190 Populus trichocarpa (black cottonwood) ENSPTRP00000013729 Pan troglodytes (chimpanzee) ENSRNOP00000033029 Rattus norvegicus (norway rat) Smp_000240.1 Schistosoma mansoni (trematode parasite) XP_001196853.1 Strongylocentrotus purpuratus (purple sea urchin) XP_970338.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014242 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019374 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004156 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18945 NV15698 LH15898 ISCW015311 FBgn0227678 FBgn0225308 FBgn0205665 FBgn0188834 FBgn0168349 JGI_V11_238350 FBgn0244229 FBgn0158931 FBgn0133974 FBgn0120039 FBgn0110168 FBgn0096046 CPIJ006342 BGIBMGA006796 ACYPI009286 GB18987 AGAP001645 AAEL005394 AAEL005382 PHUM175000 GLEAN_11980
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17010 w1118 P{EP}cazEP1564 32990 y1 sc* v1; P{TRiP.HMS00790}attP2 34839 y1 sc* v1; P{TRiP.HMS00156}attP2
VDRC	v100291 P{KK107486}VIE-260B
Genomic Clones ( 2 )
	BACR06P10 BACR13G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09207 LD22761
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10644 GH12030 GM03708 GM08888 GM19081 LD02256 LD04561 LD06336 LD09020 LD12830 LD16412 LD27742 LD33502 LD46290 LD47866 LD47879 LD47883 LP20832 LP21988 RE05486 RE06215 RE25612 RE66702 RE70738 RE71292 RE71693 RE73469 RE73516 SD06591 SD22507
Other clones	7621 30103 118414 120144.1 214283.43 CK01.81B.C5 CK01.110C.E1 Dmel_dig_007676_0584_2543 Dmel_dig_012623_0655_1898 EK062811 EK100913 EK125515 EK237629 EK251755 EP01006 FGM222G11 IP07353 IP07453
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011571 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32587
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: caz BcDNA:GM09207 (FlyBase, 1996-)
Additional comments	Source for merge of caz BcDNA:GM09207 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	caz has been cloned and sequenced, and its expression pattern has been analysed. (Immanuel et al., 1995) caz gene product contains a glycine rich C-terminal domain, but only one RNA recognition motif (RRM) located in the central portion. Intron and exon borders of full length cDNA and genomic clones have been determined and the predicted protein has 403 amino acids and is 48.4kD. UV crosslinking experiments demonstrate general RNA binding activity for the full length protein and the RRM domain. (Stolow and Haynes, 1994) Isolated from a pupal cDNA library, using a fragment of the fs(1)h coding region containing "pen" repetitive sequences (GGN, where N is any nucleotide) as the probe. (Haynes et al., 1987)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078641 RefSeq (Proteins) • NP_523365 DDBJ / EMBL / GenBank • AA697152 AA820124 AAA70425 AAA86955 AAC41563 AAM11116 AAN09389 AAO45231 AI455298 AW941337 AY094763 BT004875 L37083 M15765 U13178 Entrez Gene - A searchable database of RefSeq genes. • 32587 UniProtKB/Swiss-Prot • Q27294
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, RanBP2-type (IPR001876) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0011571 DRSC - Results from RNAi screens. • FBgn0011571 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011571 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3606-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011571 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32587 InParanoid A subset of ortholog calls from InParanoid. • AAEL005382-PA Aedes aegypti (mosquito) AGAP001645-PA Anopheles gambiae (mosquito) XP_624681.1 Apis mellifera (honey bee) XP_001948049.1 Acyrthosiphon pisum (pea aphid) At1g50300.1 Arabidopsis thaliana (wall cress) 118606 Branchiostoma floridae (lancelet) BGIBMGA006796-PA Bombyx mori (silk worm) ENSBTAP00000007571 Bos taurus (bovine) CN21497 Caenorhabditis brenneri (small nematode) CBP33968 Caenorhabditis briggsae (nematode) CE27099 Caenorhabditis elegans (worm) ENSCAFP00000024800 Canis familiaris (dog) JA04204 Caenorhabditis japonica (nematode) ENSCPOP00000008529 Cavia porcellus (guinea pig) RP47183 Caenorhabditis remanei (nematode) 222177 Capitella spl (polychaete worm) 238350 Daphnia pulex (daphnia) ENSDARP00000055339 Danio rerio (zebra fish) ENSECAP00000019904 Equus caballus (horse) ENSGACP00000019672 Gymnopilus aculeatus (mushroom) ENSGALP00000003199 Gallus gallus (chicken) 186994 Hypsipyla robusta (cedar shoot borer) ENSP00000254108 Homo sapiens (human) ISCW015311-PA Ixodes scapularis (deer tick) ENSMODP00000002300 Monodelphis domestica (gray opossum) ENSMMUP00000032452 Macaca mulatta (rhesus monkey) ENSMUSP00000101858 Mus musculus (house mouse) XP_001606397.1 Nasonia vitripennis (wasp) ENSOANP00000008923 Ornithorynchus anatinus (platypus) ENSORLP00000008429 Oryzias latipes (japanese killifish) ENSORLP00000014255 Oryzias latipes (japanese killifish) LOC_Os09g12800.1 Oryza sativa (asian rice) 164439 Physcomitrella patens (moss) ENSPPYP00000008259 Pongo pygmaeus (orangutan) 156131 Phytophthora sojae (root rot pathogen) 564190 Populus trichocarpa (black cottonwood) ENSPTRP00000013729 Pan troglodytes (chimpanzee) ENSRNOP00000033029 Rattus norvegicus (norway rat) Smp_000240.1 Schistosoma mansoni (trematode parasite) XP_001196853.1 Strongylocentrotus purpuratus (purple sea urchin) XP_970338.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014242 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019374 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004156 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32587 modMine - Data generated by the modENCODE project. • FBgn0011571 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18945 NV15698 LH15898 ISCW015311 FBgn0227678 FBgn0225308 FBgn0205665 FBgn0188834 FBgn0168349 JGI_V11_238350 FBgn0244229 FBgn0158931 FBgn0133974 FBgn0120039 FBgn0110168 FBgn0096046 CPIJ006342 BGIBMGA006796 ACYPI009286 GB18987 AGAP001645 AAEL005394 AAEL005382 PHUM175000 GLEAN_11980
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	anon-Pen19   BcDNA:GM09207   cas (Robertson, 2001.1.8) caz (Legube et al., 2006, Herold et al., 2009, Zhou et al., 2008) CG3606 (Aoyagi and Wassarman, 2000, Grieder et al., 2007, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2010.12.1, Ni et al., 2011.7.19) P19 (Stolow and Haynes, 1994, ) p19 (Haynes et al., 1987) pen19   Pen19   SARFH (Immanuel, 1994.8.8, Immanuel et al., 1995) Sarfh   TFIID (Butler and Kadonaga, 2002)
Name Synonym	cabeza (Stolow, 1994) CABEZA (Minakhina et al., 2003) Sarcoma-associated RNA-binding fly homolog (Immanuel et al., 1995, )
Secondary FlyBase IDs
	FBgn0003059 FBgn0011830 FBgn0062479
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Thesis  ( 1 )
Recent research papers ( 3 )
	Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Wang et al., 2011, J. clin. Invest. 121(10): 4118--4126 The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. [FBrf0216240] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...