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Gene Dmel\Cdc37

General Information
Symbol	Dmel\Cdc37	Species	D. melanogaster
Name	Cdc37	Annotation symbol	CG12019
Feature type	protein_coding_gene	FlyBase ID	FBgn0011573
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	E(sev)3B
Genomic Location
Chromosome (arm)	3L	Recombination map	3-5
Cytogenetic map	62B4-62B4	Sequence location	3L:1,795,392..1,797,307 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cdc37 is referred to in FlyBase by the symbol Dmel\Cdc37 (CG12019, FBgn0011573). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: unfolded protein binding. There is experimental evidence that it is involved in the biological process: neurogenesis. 20 alleles are reported. The phenotypes of these alleles are annotated with: actomyosin contractile ring; rhabdomere; adult abdomen; spermatid; spindle; nucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: Cdc37; Cdc37, C-terminal; Cdc37, Hsp90 binding; Cdc37, N-terminal domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630283_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cdc37. Gene sequence location is 3L:1795392..1797307.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B4-62B4   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References 62B4-62B5     (Cutforth, 1994.7.16)
Experimentally Determined Recombination Data
Location	3-5 (Simon et al., 1991)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cdc37 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cdc37-RA FBtr0072777  NM_057658   1611   389
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cdc37-PA   FBpp0072660   45.1   389   4.70     NP_477006   AAF47571
Additional Polypeptide Data & Comments
Reported size (kDa)	389 (aa); 58 (kD observed); 45 (kD predicted) (Cutforth and Rubin, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cdc37 (IPR004918) Cdc37, N-terminal domain (IPR013855) Cdc37, C-terminal (IPR013873) Cdc37, Hsp90 binding (IPR013874)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246851   AA438724   AA440650   AA538590   AA694731   AA735584   AA803117   AA817109   AA817409   AA820238   AA942371   AA948811   AA949081   AA950982   AA950984   AA951300   AA990802   AE014296 AAF47571   AC005557   AF067899   AF067900   AI061760   AI134738   AI294477   AI296237   AI389745   AI514500   AI515792   AI518446   AI519209   AI520515   AI542663   AI945064   BE975923   BE976094   BF488999   BF498726   BF498858   BF500345   BF505589   BG641363   BI352199   BI614598   BI625098   BI625411   BI640162   BI640184   BI641234   BI641789   BP549023   BQ103597   BT004828 AAO45184   BT083438   CK661587   CO154859   CO177467   CO182698   CO315832   EC089308   EC194723   EC218432   EC228116   EC262867   L32839 AAA28414
UniProtKB/Swiss-Prot	Q24276
UniProtKB/TrEMBL	Q86NM8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Cutforth and Rubin, 1994) embryonic stage | late     (Cutforth and Rubin, 1994) third instar larval stage   eye-antennal disc   (Cutforth and Rubin, 1994)
Additional Descriptive Data
	Cdc37 protein is ubiquitously distributed in the cytoplasm of cellularized embryos. It is also ubiquitously expressed in late embryos and third instar eye imaginal disc. (Cutforth and Rubin, 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Cutforth and Rubin, 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis    502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis  502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis    502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis    502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis    502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis  502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis    502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    379.65 Larval Midgut    200.4 Larval Hindgut    336.2 Larval Malpighian Tubules    484.4 Larval Fat Body    434.5 Larval Salivary Gland    303.6 Larval Trachea    471.05 Larval Carcass    319.65 Adult Head    273.1 Adult Eye    391.175 Adult Brain    241.1 Adult Thoracic-Abdominal Ganglion    231.6 Adult Crop    391.5 Adult Midgut    252.6 Adult Hindgut    327 Adult Malpighian Tubules    430.6 Adult Fat Body    232.9 Adult Salivary Gland    216.9 Adult Heart    259.125 Adult VirginFemale Spermatheca    420.6 Adult InseminatedFemale Spermatheca    410 Adult Ovary    461.5 Adult Testis    502.5 Adult Male Accessory Gland    194.1 Adult Carcass    265 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    273.1   NA  Eye    391.175   NA  Brain    241.1   379.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    231.6   NA  Crop    391.5   200.4  Midgut    252.6   336.2  Hindgut    327   484.4  Malpighian Tubules    430.6   434.5  Fat Body    232.9   303.6  Salivary Gland    216.9   NA  Heart    259.125   471.05  Trachea    NA   NA  VirginFemale Spermatheca    420.6   NA  InseminatedFemale Spermatheca    410   NA  Ovary    461.5   NA  Testis    502.5   NA  Male Accessory Gland    194.1   319.65  Carcass    265 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    160 central nervous system, larvae L3    139 central nervous system, pupae P8    60 head, virgin 1-day female    39 head, virgin 4-day female    45 head, virgin 20-day female    35 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    32 head, mated 1-day male    49 head, mated 4-day male    53 head, mated 20-day male    65 salivary gland, larvae L3 wandering    48 salivary gland, white prepupae    129 digestive system, larvae L3 wandering    106 digestive system, 1-day adult    46 digestive system, 4-day adult    62 digestive system, 20-day adult    52 fat body, larvae L3 wandering    38 fat body, white prepupae    110 fat body, pupae P8    108 carcass, larvae L3 wandering    139 carcass, 1-day adult    36 carcass, 4-day adult    43 carcass, 20-day adult    40 ovary, virgin 4-day female    138 ovary, mated 4-day female    158 testis, mated 4-day male    206 accessory gland, mated 4-day male    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (160) central nervous system, larvae L3  (139) central nervous system, pupae P8  (60) head, virgin 1-day female  (39) head, virgin 4-day female  (45) head, virgin 20-day female  (35) head, mated 1-day female  (40) head, mated 4-day female  (47) head, mated 20-day female  (32) head, mated 1-day male  (49) head, mated 4-day male  (53) head, mated 20-day male  (65) salivary gland, larvae L3 wandering  (48) salivary gland, white prepupae  (129) digestive system, larvae L3 wandering  (106) digestive system, 1-day adult  (46) digestive system, 4-day adult  (62) digestive system, 20-day adult  (52) fat body, larvae L3 wandering  (38) fat body, white prepupae  (110) fat body, pupae P8  (108) carcass, larvae L3 wandering  (139) carcass, 1-day adult  (36) carcass, 4-day adult  (43) carcass, 20-day adult  (40) ovary, virgin 4-day female  (138) ovary, mated 4-day female  (158) testis, mated 4-day male  (206) accessory gland, mated 4-day male  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (160) central nervous system, larvae L3  (139) central nervous system, pupae P8    60 head, virgin 1-day female    39 head, virgin 4-day female    45 head, virgin 20-day female    35 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    32 head, mated 1-day male    49 head, mated 4-day male    53 head, mated 20-day male    65 salivary gland, larvae L3 wandering    48 salivary gland, white prepupae  (129) digestive system, larvae L3 wandering  106 digestive system, 1-day adult    46 digestive system, 4-day adult    62 digestive system, 20-day adult    52 fat body, larvae L3 wandering    38 fat body, white prepupae  (110) fat body, pupae P8  (108) carcass, larvae L3 wandering  (139) carcass, 1-day adult    36 carcass, 4-day adult    43 carcass, 20-day adult    40 ovary, virgin 4-day female  (138) ovary, mated 4-day female  (158) testis, mated 4-day male  (206) accessory gland, mated 4-day male    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    160 central nervous system, larvae L3    139 central nervous system, pupae P8    60 head, virgin 1-day female    39 head, virgin 4-day female    45 head, virgin 20-day female    35 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    32 head, mated 1-day male    49 head, mated 4-day male    53 head, mated 20-day male    65 salivary gland, larvae L3 wandering    48 salivary gland, white prepupae    129 digestive system, larvae L3 wandering    106 digestive system, 1-day adult    46 digestive system, 4-day adult    62 digestive system, 20-day adult    52 fat body, larvae L3 wandering    38 fat body, white prepupae    110 fat body, pupae P8    108 carcass, larvae L3 wandering    139 carcass, 1-day adult    36 carcass, 4-day adult    43 carcass, 20-day adult    40 ovary, virgin 4-day female    138 ovary, mated 4-day female    158 testis, mated 4-day male    206 accessory gland, mated 4-day male    44 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    160 central nervous system, larvae L3    139 central nervous system, pupae P8    60 head, virgin 1-day female    39 head, virgin 4-day female    45 head, virgin 20-day female    35 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    32 head, mated 1-day male    49 head, mated 4-day male    53 head, mated 20-day male    65 salivary gland, larvae L3 wandering    48 salivary gland, white prepupae    129 digestive system, larvae L3 wandering    106 digestive system, 1-day adult    46 digestive system, 4-day adult    62 digestive system, 20-day adult    52 fat body, larvae L3 wandering    38 fat body, white prepupae    110 fat body, pupae P8    108 carcass, larvae L3 wandering    139 carcass, 1-day adult    36 carcass, 4-day adult    43 carcass, 20-day adult    40 ovary, virgin 4-day female    138 ovary, mated 4-day female    158 testis, mated 4-day male    206 accessory gland, mated 4-day male    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (160) central nervous system, larvae L3  (139) central nervous system, pupae P8  (60) head, virgin 1-day female  (39) head, virgin 4-day female  (45) head, virgin 20-day female  (35) head, mated 1-day female  (40) head, mated 4-day female  (47) head, mated 20-day female  32 head, mated 1-day male  (49) head, mated 4-day male  (53) head, mated 20-day male  (65) salivary gland, larvae L3 wandering  (48) salivary gland, white prepupae  (129) digestive system, larvae L3 wandering  (106) digestive system, 1-day adult  (46) digestive system, 4-day adult  (62) digestive system, 20-day adult  (52) fat body, larvae L3 wandering  (38) fat body, white prepupae  (110) fat body, pupae P8  (108) carcass, larvae L3 wandering  (139) carcass, 1-day adult  (36) carcass, 4-day adult  (43) carcass, 20-day adult  (40) ovary, virgin 4-day female  (138) ovary, mated 4-day female  (158) testis, mated 4-day male  (206) accessory gland, mated 4-day male  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (160) central nervous system, larvae L3  139 central nervous system, pupae P8    60 head, virgin 1-day female    39 head, virgin 4-day female    45 head, virgin 20-day female    35 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    32 head, mated 1-day male    49 head, mated 4-day male    53 head, mated 20-day male    65 salivary gland, larvae L3 wandering    48 salivary gland, white prepupae  129 digestive system, larvae L3 wandering  106 digestive system, 1-day adult    46 digestive system, 4-day adult    62 digestive system, 20-day adult    52 fat body, larvae L3 wandering    38 fat body, white prepupae  110 fat body, pupae P8  108 carcass, larvae L3 wandering  139 carcass, 1-day adult    36 carcass, 4-day adult    43 carcass, 20-day adult    40 ovary, virgin 4-day female  138 ovary, mated 4-day female  (158) testis, mated 4-day male  (206) accessory gland, mated 4-day male    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    160 central nervous system, larvae L3    139 central nervous system, pupae P8    60 head, virgin 1-day female    39 head, virgin 4-day female    45 head, virgin 20-day female    35 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    32 head, mated 1-day male    49 head, mated 4-day male    53 head, mated 20-day male    65 salivary gland, larvae L3 wandering    48 salivary gland, white prepupae    129 digestive system, larvae L3 wandering    106 digestive system, 1-day adult    46 digestive system, 4-day adult    62 digestive system, 20-day adult    52 fat body, larvae L3 wandering    38 fat body, white prepupae    110 fat body, pupae P8    108 carcass, larvae L3 wandering    139 carcass, 1-day adult    36 carcass, 4-day adult    43 carcass, 20-day adult    40 ovary, virgin 4-day female    138 ovary, mated 4-day female    158 testis, mated 4-day male    206 accessory gland, mated 4-day male    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    81 embryo 04-06hr    81 embryo 06-08hr    88 embryo 08-10hr    78 embryo 10-12hr    65 embryo 12-14hr    43 embryo 14-16hr    34 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    32 embryo 22-24hr    29 larva L1    41 larva L2    41 larva L3 12hr old    34 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    72 white prepupae new    74 white prepupae 12hr    77 white prepupae 24hr    76 pupae 2d postWPP    64 pupae 3d postWPP    47 pupae 4d postWPP    39 adult male 01day    47 adult male 05day    58 adult male 30day    54 adult female 01day    45 adult female 05day    71 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (94) embryo 02-04hr  (81) embryo 04-06hr  (81) embryo 06-08hr  (88) embryo 08-10hr  (78) embryo 10-12hr  (65) embryo 12-14hr  (43) embryo 14-16hr  (34) embryo 16-18hr  (32) embryo 18-20hr  (30) embryo 20-22hr  (32) embryo 22-24hr  (29) larva L1  (41) larva L2  (41) larva L3 12hr old  (34) larva L3 puffstage 1-2  (41) larva L3 puffstage 3-6  (58) larva L3 puffstage 7-9  (72) white prepupae new  (74) white prepupae 12hr  (77) white prepupae 24hr  (76) pupae 2d postWPP  (64) pupae 3d postWPP  (47) pupae 4d postWPP  (39) adult male 01day  (47) adult male 05day  (58) adult male 30day  (54) adult female 01day  (45) adult female 05day  (71) adult female 30day  (72) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    81 embryo 04-06hr    81 embryo 06-08hr    88 embryo 08-10hr    78 embryo 10-12hr    65 embryo 12-14hr    43 embryo 14-16hr    34 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    32 embryo 22-24hr    29 larva L1    41 larva L2    41 larva L3 12hr old    34 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    72 white prepupae new    74 white prepupae 12hr    77 white prepupae 24hr    76 pupae 2d postWPP    64 pupae 3d postWPP    47 pupae 4d postWPP    39 adult male 01day    47 adult male 05day    58 adult male 30day    54 adult female 01day    45 adult female 05day    71 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    81 embryo 04-06hr    81 embryo 06-08hr    88 embryo 08-10hr    78 embryo 10-12hr    65 embryo 12-14hr    43 embryo 14-16hr    34 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    32 embryo 22-24hr    29 larva L1    41 larva L2    41 larva L3 12hr old    34 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    72 white prepupae new    74 white prepupae 12hr    77 white prepupae 24hr    76 pupae 2d postWPP    64 pupae 3d postWPP    47 pupae 4d postWPP    39 adult male 01day    47 adult male 05day    58 adult male 30day    54 adult female 01day    45 adult female 05day    71 adult female 30day    72 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    81 embryo 04-06hr    81 embryo 06-08hr    88 embryo 08-10hr    78 embryo 10-12hr    65 embryo 12-14hr    43 embryo 14-16hr    34 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    32 embryo 22-24hr    29 larva L1    41 larva L2    41 larva L3 12hr old    34 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    72 white prepupae new    74 white prepupae 12hr    77 white prepupae 24hr    76 pupae 2d postWPP    64 pupae 3d postWPP    47 pupae 4d postWPP    39 adult male 01day    47 adult male 05day    58 adult male 30day    54 adult female 01day    45 adult female 05day    71 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (94) embryo 02-04hr  (81) embryo 04-06hr  (81) embryo 06-08hr  (88) embryo 08-10hr  (78) embryo 10-12hr  (65) embryo 12-14hr  (43) embryo 14-16hr  (34) embryo 16-18hr  32 embryo 18-20hr  30 embryo 20-22hr  32 embryo 22-24hr  29 larva L1  (41) larva L2  (41) larva L3 12hr old  (34) larva L3 puffstage 1-2  (41) larva L3 puffstage 3-6  (58) larva L3 puffstage 7-9  (72) white prepupae new  (74) white prepupae 12hr  (77) white prepupae 24hr  (76) pupae 2d postWPP  (64) pupae 3d postWPP  (47) pupae 4d postWPP  (39) adult male 01day  (47) adult male 05day  (58) adult male 30day  (54) adult female 01day  (45) adult female 05day  (71) adult female 30day  (72) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    81 embryo 04-06hr    81 embryo 06-08hr    88 embryo 08-10hr    78 embryo 10-12hr    65 embryo 12-14hr    43 embryo 14-16hr    34 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    32 embryo 22-24hr    29 larva L1    41 larva L2    41 larva L3 12hr old    34 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    72 white prepupae new    74 white prepupae 12hr    77 white prepupae 24hr    76 pupae 2d postWPP    64 pupae 3d postWPP    47 pupae 4d postWPP    39 adult male 01day    47 adult male 05day    58 adult male 30day    54 adult female 01day    45 adult female 05day    71 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    81 embryo 04-06hr    81 embryo 06-08hr    88 embryo 08-10hr    78 embryo 10-12hr    65 embryo 12-14hr    43 embryo 14-16hr    34 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    32 embryo 22-24hr    29 larva L1    41 larva L2    41 larva L3 12hr old    34 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    72 white prepupae new    74 white prepupae 12hr    77 white prepupae 24hr    76 pupae 2d postWPP    64 pupae 3d postWPP    47 pupae 4d postWPP    39 adult male 01day    47 adult male 05day    58 adult male 30day    54 adult female 01day    45 adult female 05day    71 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    314 Schneider line 2 Sg4    128 embryonic 1182-4H    172 embryonic GM2    104 embryonic Kc167    81 embryonic S1    439 embryonic S3    143 leg disc CME L1    196 wing disc CME-W2    117 wing disc ML-DmD8    281 wing disc ML-DmD9    208 wing disc ML-DmD16-c3    294 wing disc ML-DmD21    118 wing disc ML-DmD32    158 haltere disc ML-DmD17-c3    177 eye-antennal disc ML-DmD11    109 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    317 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    92 ovary fGS/OSS    164 ovary OSC    191 ovary OSS    82 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (314) Schneider line 2 Sg4  (128) embryonic 1182-4H  (172) embryonic GM2  (104) embryonic Kc167  (81) embryonic S1  (439) embryonic S3  (143) leg disc CME L1  (196) wing disc CME-W2  (117) wing disc ML-DmD8  (281) wing disc ML-DmD9  (208) wing disc ML-DmD16-c3  (294) wing disc ML-DmD21  (118) wing disc ML-DmD32  (158) haltere disc ML-DmD17-c3  (177) eye-antennal disc ML-DmD11  (109) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (317) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2  (92) ovary fGS/OSS  (164) ovary OSC  (191) ovary OSS  (82) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (314) Schneider line 2 Sg4  (128) embryonic 1182-4H  (172) embryonic GM2  104 embryonic Kc167    81 embryonic S1  (439) embryonic S3  (143) leg disc CME L1  (196) wing disc CME-W2  (117) wing disc ML-DmD8  (281) wing disc ML-DmD9  (208) wing disc ML-DmD16-c3  (294) wing disc ML-DmD21  (118) wing disc ML-DmD32  (158) haltere disc ML-DmD17-c3  (177) eye-antennal disc ML-DmD11  (109) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (317) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2    92 ovary fGS/OSS  (164) ovary OSC  (191) ovary OSS    82 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    314 Schneider line 2 Sg4    128 embryonic 1182-4H    172 embryonic GM2    104 embryonic Kc167    81 embryonic S1    439 embryonic S3    143 leg disc CME L1    196 wing disc CME-W2    117 wing disc ML-DmD8    281 wing disc ML-DmD9    208 wing disc ML-DmD16-c3    294 wing disc ML-DmD21    118 wing disc ML-DmD32    158 haltere disc ML-DmD17-c3    177 eye-antennal disc ML-DmD11    109 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    317 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    92 ovary fGS/OSS    164 ovary OSC    191 ovary OSS    82 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    314 Schneider line 2 Sg4    128 embryonic 1182-4H    172 embryonic GM2    104 embryonic Kc167    81 embryonic S1    439 embryonic S3    143 leg disc CME L1    196 wing disc CME-W2    117 wing disc ML-DmD8    281 wing disc ML-DmD9    208 wing disc ML-DmD16-c3    294 wing disc ML-DmD21    118 wing disc ML-DmD32    158 haltere disc ML-DmD17-c3    177 eye-antennal disc ML-DmD11    109 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    317 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    92 ovary fGS/OSS    164 ovary OSC    191 ovary OSS    82 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (314) Schneider line 2 Sg4  (128) embryonic 1182-4H  (172) embryonic GM2  (104) embryonic Kc167  (81) embryonic S1  (439) embryonic S3  (143) leg disc CME L1  (196) wing disc CME-W2  (117) wing disc ML-DmD8  (281) wing disc ML-DmD9  (208) wing disc ML-DmD16-c3  (294) wing disc ML-DmD21  (118) wing disc ML-DmD32  (158) haltere disc ML-DmD17-c3  (177) eye-antennal disc ML-DmD11  (109) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (317) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2  (92) ovary fGS/OSS  (164) ovary OSC  (191) ovary OSS  (82) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (314) Schneider line 2 Sg4  128 embryonic 1182-4H  (172) embryonic GM2  104 embryonic Kc167    81 embryonic S1  (439) embryonic S3  143 leg disc CME L1  (196) wing disc CME-W2  117 wing disc ML-DmD8  (281) wing disc ML-DmD9  (208) wing disc ML-DmD16-c3  (294) wing disc ML-DmD21  118 wing disc ML-DmD32  (158) haltere disc ML-DmD17-c3  (177) eye-antennal disc ML-DmD11  109 antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (317) CNS ML-DmBG2-c2  (174) tumorous blood cells mbn2    92 ovary fGS/OSS  (164) ovary OSC  (191) ovary OSS    82 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    314 Schneider line 2 Sg4    128 embryonic 1182-4H    172 embryonic GM2    104 embryonic Kc167    81 embryonic S1    439 embryonic S3    143 leg disc CME L1    196 wing disc CME-W2    117 wing disc ML-DmD8    281 wing disc ML-DmD9    208 wing disc ML-DmD16-c3    294 wing disc ML-DmD21    118 wing disc ML-DmD32    158 haltere disc ML-DmD17-c3    177 eye-antennal disc ML-DmD11    109 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    317 CNS ML-DmBG2-c2    174 tumorous blood cells mbn2    92 ovary fGS/OSS    164 ovary OSC    191 ovary OSS    82 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    82 cold shock, 4-day adult    67 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    58 Cadmium 50 mM 12 hrs, larvae L3    78 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    127 Copper 0.5 mM 12 hrs, larvae L3    81 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    70 Zinc 4.5 mM 48 hrs, 4-day adult    57 Ethanol 2.5% 3 hrs, larvae L3    126 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    61 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    72 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (82) cold shock, 4-day adult  (67) heat shock, 4-day adult  (108) Cadmium 50 mM 6 hrs, larvae L3  (58) Cadmium 50 mM 12 hrs, larvae L3  (78) Cadmium 50 mM 48 hrs, 4-day adult  (86) Cadmium 100 mM 48 hrs, 4-day adult  (127) Copper 0.5 mM 12 hrs, larvae L3  (81) Copper 15 mM 48 hrs, 4-day adult  (76) Zinc 5 mM 12 hrs, larvae L3  (70) Zinc 4.5 mM 48 hrs, 4-day adult  (57) Ethanol 2.5% 3 hrs, larvae L3  (126) Ethanol 5% 3 hrs, larvae L3  (44) Ethanol 10% 3 hrs, larvae L3  (61) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (113) Caffeine 25 mg/ml 48 hrs, 4-day adult  (72) Paraquat 5 mM 48 hrs, 4-day adult  (98) Paraquat 10 mM 48 hrs, 4-day adult  (93) Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    82 cold shock, 4-day adult    67 heat shock, 4-day adult  (108) Cadmium 50 mM 6 hrs, larvae L3    58 Cadmium 50 mM 12 hrs, larvae L3    78 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult  (127) Copper 0.5 mM 12 hrs, larvae L3    81 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    70 Zinc 4.5 mM 48 hrs, 4-day adult    57 Ethanol 2.5% 3 hrs, larvae L3  (126) Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    61 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (113) Caffeine 25 mg/ml 48 hrs, 4-day adult    72 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    82 cold shock, 4-day adult    67 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    58 Cadmium 50 mM 12 hrs, larvae L3    78 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    127 Copper 0.5 mM 12 hrs, larvae L3    81 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    70 Zinc 4.5 mM 48 hrs, 4-day adult    57 Ethanol 2.5% 3 hrs, larvae L3    126 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    61 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    72 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    58 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    82 cold shock, 4-day adult    67 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    58 Cadmium 50 mM 12 hrs, larvae L3    78 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    127 Copper 0.5 mM 12 hrs, larvae L3    81 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    70 Zinc 4.5 mM 48 hrs, 4-day adult    57 Ethanol 2.5% 3 hrs, larvae L3    126 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    61 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    72 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (82) cold shock, 4-day adult  (67) heat shock, 4-day adult  (108) Cadmium 50 mM 6 hrs, larvae L3  (58) Cadmium 50 mM 12 hrs, larvae L3  (78) Cadmium 50 mM 48 hrs, 4-day adult  (86) Cadmium 100 mM 48 hrs, 4-day adult  (127) Copper 0.5 mM 12 hrs, larvae L3  (81) Copper 15 mM 48 hrs, 4-day adult  (76) Zinc 5 mM 12 hrs, larvae L3  (70) Zinc 4.5 mM 48 hrs, 4-day adult  (57) Ethanol 2.5% 3 hrs, larvae L3  (126) Ethanol 5% 3 hrs, larvae L3  (44) Ethanol 10% 3 hrs, larvae L3  (61) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (113) Caffeine 25 mg/ml 48 hrs, 4-day adult  (72) Paraquat 5 mM 48 hrs, 4-day adult  (98) Paraquat 10 mM 48 hrs, 4-day adult  (93) Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    82 cold shock, 4-day adult    67 heat shock, 4-day adult  108 Cadmium 50 mM 6 hrs, larvae L3    58 Cadmium 50 mM 12 hrs, larvae L3    78 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult  127 Copper 0.5 mM 12 hrs, larvae L3    81 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    70 Zinc 4.5 mM 48 hrs, 4-day adult    57 Ethanol 2.5% 3 hrs, larvae L3  126 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    61 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  113 Caffeine 25 mg/ml 48 hrs, 4-day adult    72 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    82 cold shock, 4-day adult    67 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    58 Cadmium 50 mM 12 hrs, larvae L3    78 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    127 Copper 0.5 mM 12 hrs, larvae L3    81 Copper 15 mM 48 hrs, 4-day adult    76 Zinc 5 mM 12 hrs, larvae L3    70 Zinc 4.5 mM 48 hrs, 4-day adult    57 Ethanol 2.5% 3 hrs, larvae L3    126 Ethanol 5% 3 hrs, larvae L3    44 Ethanol 10% 3 hrs, larvae L3    61 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    72 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    93 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12019-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Cdc37GD14633 lethal | larval stage (with Cdc37e1C) Cdc37e6B lethal | larval stage (with Cdc37e1E) Cdc37e6B lethal | larval stage (with Cdc37e4D) Cdc37e6B lethal | larval stage (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D lethal | pupal stage, with Scer\GAL4pnr-MD237 Cdc37GD14633 lethal | recessive Cdc37e1C Cdc37e1E Cdc37e4D Cdc37e6B lethal | second instar larval stage, with Df(3L)MY10 Cdc37+t9.5.Δdpatj Other Phenotypes Allele cell polarity defective | somatic clone, with Df(3L)MY10 Cdc37+t9.5.Δdpatj cytokinesis defective (with Cdc37e1C) Cdc37e6B cytokinesis defective (with Cdc37e1E) Cdc37e6B cytokinesis defective (with Cdc37e4D) Cdc37e6B cytokinesis defective (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D increased cell size Cdc37dsRNA.cLa meiotic cell cycle defective (with Cdc37e1C) Cdc37e6B meiotic cell cycle defective (with Cdc37e1E) Cdc37e6B meiotic cell cycle defective (with Cdc37e4D) Cdc37e6B meiotic cell cycle defective (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D mitotic cell cycle defective Cdc37dsRNA.cLa neuroanatomy defective | larval stage Cdc37GD14633 wild-type Cdc37+t9.5 Cdc37+tCOSMY1-1 Cdc37+tCOSMY8-1 Cdc37+tpW8spKA Cdc37EHHS Phenotype manifest in Allele actomyosin contractile ring (with Cdc37e1C) Cdc37e6B actomyosin contractile ring (with Cdc37e1E) Cdc37e6B actomyosin contractile ring (with Cdc37e4D) Cdc37e6B actomyosin contractile ring (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D adult abdomen Cdc37e1E anaphase & condensed nuclear chromosome (with Cdc37e1C) Cdc37e6B anaphase & condensed nuclear chromosome (with Cdc37e1E) Cdc37e6B anaphase & condensed nuclear chromosome (with Cdc37e4D) Cdc37e6B anaphase & condensed nuclear chromosome (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D embryonic/larval neuroblast | larval stage Cdc37GD14633 eye photoreceptor cell | somatic clone, with Df(3L)MY10 Cdc37+t9.5.Δdpatj ganglion mother cell | larval stage Cdc37GD14633 mitosis & nuclear chromosome Cdc37dsRNA.cLa nucleus Cdc37dsRNA.cLa ommatidium | somatic clone, with Df(3L)MY10 Cdc37+t9.5.Δdpatj rhabdomere, with Df(3L)MY10 Cdc37+t9.5 rhabdomere | somatic clone, with Df(3L)MY10 Cdc37+t9.5.Δdpatj spermatid (with Cdc37e1C) Cdc37e6B spermatid (with Cdc37e1E) Cdc37e6B spermatid (with Cdc37e4D) Cdc37e6B spermatid (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D spindle Cdc37dsRNA.cLa spindle (with Cdc37e1C) Cdc37e6B spindle (with Cdc37e1E) Cdc37e6B spindle (with Cdc37e4D) Cdc37e6B spindle (with Cdc37e6B) Cdc37e1C Cdc37e1E Cdc37e4D
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Cdc37 Class Mutagen Stocks Known lesion Cdc37e4D 2 Yes Cdc375-SZ-3021 1 -- Cdc37G7101 P-element activity 1 -- Cdc37e1C 0 -- Cdc37e1E 0 Yes Cdc37e6B hypomorphic allele - genetic evidence 0 Yes Cdc37unspecified 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cdc37 Class Mutagen Stocks Known lesion Cdc37GD14633 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cdc37HMS01401 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cdc37JF03184 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cdc37+t9.5.Δdpatj in vitro construct - genomic fragment in vitro construct - deletion 0 Yes Cdc37+t9.5 in vitro construct - genomic fragment 0 Yes Cdc37+tCOSMY1-1 in vitro construct - genomic fragment 0 Yes Cdc37+tCOSMY8-1 in vitro construct - genomic fragment 0 Yes Cdc37+tpW8spKA in vitro construct - genomic fragment 0 Yes Cdc37dsRNA.cLa in vitro construct - RNAi 0 Yes Cdc37EHHS in vitro construct - genomic fragment 0 Yes Cdc37GD1220 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cdc37KK102575 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cdc37NIG.12019R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Aprt-126 (Bhat et al., 1999) Df(3L)BSC123 (Andrade and Cook, 2005.8.25) Df(3L)BSC181 (Gresens and Cook, 2006.12.5) Df(3L)Exel6088 (Ryder, 2004.4.26) Df(3L)MY10 (Bhat et al., 1999, Tanentzapf et al., 2000, Pielage et al., 2003) Df(3L)R-G2 (Cutforth and Rubin, 1994) Df(3L)R-G5 (Cutforth and Rubin, 1994) Df(3L)R-R2 (Cutforth and Rubin, 1994) In(3L)Cdc37e1C (Cutforth and Rubin, 1994)
Not disrupted in	Df(3L)R-E (Cutforth and Rubin, 1994) Df(3L)R-G7 (Cutforth and Rubin, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1220} NA P{GD14633} NA P{KK102575} NA P{NIG.12019R} NA P{TRiP.HMS01401} NA P{TRiP.JF03184} NA characterization construct P{COSMY1-1} NA P{COSMY8-1} NA P{PatjEHHS} NA P{PatjEΔHS} NA P{pW8K/ScII.ΔPatj} NA P{pW8K/ScII} NA P{pW8spKA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}Cdc375-SZ-3021 NA insertion of mobile activating element P{EP}Cdc37G7101 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Cutforth and Rubin, 1994)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
chaperone binding non-traceable author statement (assigned by UniProtKB) (Cutforth and Rubin, 1994) protein kinase binding inferred from electronic annotation with InterPro:IPR013855 (FlyBase Curators et al., 2004-) protein tyrosine kinase activator activity non-traceable author statement (assigned by UniProtKB) (Cutforth and Rubin, 1994) unfolded protein binding inferred from sequence or structural similarity with Saccharomyces CDC37 (FlyBase, 1992-)
Biological Process
CV term Evidence References
intracellular protein kinase cascade non-traceable author statement (assigned by UniProtKB) (Cutforth and Rubin, 1994) transmembrane receptor protein tyrosine kinase signaling pathway non-traceable author statement (Cutforth, 1994.7.16)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cdc37 - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - Cdk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - Src64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - fzo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - grp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - sax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdc37 - ytr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cdc37 allele Gene References Cdc37e1C sev (Simon et al., 1991) Cdc37e1E cdc2 (Cutforth and Rubin, 1994) Rho1 (Hariharan et al., 1995) sev (Simon et al., 1991) Cdc37e4D sev (Simon et al., 1991)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63764 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011573 DroID - A comprehensive database of gene and protein interactions. • FBgn0011573 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38232
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TQMW0 Dipteran inclusive ortholog search EOG6JHCQC Insect inclusive ortholog search EOG6WM3QD Arthropod inclusive ortholog search EOG6JSXN6 Metazoa inclusive ortholog search EOG6FJN3W
Orthologs in Drosophila Species (EOG6TQMW0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cdc37     Drosophila simulans   Dsim\Cdc37 Y   Drosophila sechellia   Dsec\Cdc37 Y   Drosophila erecta   Dere\GG14824 Y   Drosophila yakuba   Dyak\GE21187 Y   Drosophila ananassae   Dana\GF24836 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11342 Y   Drosophila persimilis   Dper\GL25303 Y   Drosophila willistoni   Dwil\GK20531 Y   Drosophila virilis   Dvir\Cdc37 Y   Drosophila mojavensis   Dmoj\GI12516 Y   Drosophila grimshawi   Dgri\GH16432 Y
Orthologs in non-Drosophila Dipterans (EOG6JHCQC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010057   Anopheles gambiae Malaria mosquito  Agam\AGAP001914   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007320
Orthologs in non-Dipteran Insects (EOG6WM3QD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52345   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004092   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17853   Atta cephalotes Leafcutter ant  Acep\ACEP21577   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18871   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17926   Linepithema humile Argentine ant  Lhum\LH16492   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10804   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006313   Bombyx mori Silkmoth  Bmor\BGIBMGA010245   Pediculus humanus Human body louse  Phum\PHUM253670   Tribolium castaneum Red flour beetle  Tcas\TC013118
Orthologs in non-Insect Arthropods (EOG6JSXN6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306914   Ixodes scapularis Deer tick  Isca\ISCW021899
Orthologs in non-Arthropod Metazoa (EOG6FJN3W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K07E8.6   Caenorhabditis elegans Nematode  Cele\cdc-37   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014577gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024241gn   Danio rerio Zebrafish  Drer\CABZ01043370.1   Xenopus tropicalis Western clawed frog  Xtro\cdc37   Mus musculus House mouse  Mmus\Cdc37   Rattus norvegicus Norway rat  Rnor\Cdc37   Homo sapiens Human  Hsap\CDC37
Human Orthologs (1)
Gene OMIM HGNC Hsap\CDC37
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Cdc37 Drosophila sechellia Dsec\Cdc37 Drosophila erecta Dere\GG14824 Drosophila yakuba Dyak\GE21187 Drosophila ananassae Dana\GF24836 Drosophila pseudoobscura pseudoobscura Dpse\GA11342 Drosophila persimilis Dper\GL25303 Drosophila willistoni Dwil\GK20531 Drosophila virilis Dvir\Cdc37 Drosophila mojavensis Dmoj\GI12516 Drosophila grimshawi Dgri\GH16432
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	28756 y1 v1; P{TRiP.JF03184}attP2 5693 w*; Cdc37e4D/TM6B, Tb1 27222 y1 w*; P{EP}Cdc37G7101 34991 y1 sc* v1; P{TRiP.HMS01401}attP2/TM3, Sb1
Kyoto	125840 w1118; P{RS5}Cdc375-SZ-3021 108370 w*; Cdc37e4D/TM6B, Tb1
VDRC	v29182 w1118 P{GD14633}v29182 v47776 w1118; P{GD14633}v47776/TM3
Genomic Clones ( 1 )
	BACR10D15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD25413
Other clones	DPiM_FI07667 FI07667
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07847 AT13188 AT13416 AT15196 AT24682 GH12276 GH20989 GM01424 GM07061 GM18283 LD05876 LD13064 LD15504 LD18155 LD21574 LD22215 LD22680 LD23749 LD26531 LD27462 LD27840 LD31182 LD31184 LD31693 LD34689 LD34866 LD37960 LD38722 LD40696 LD41027 LD41463 LP07857 LP10085 LP21187 RH44011 RH64944 RH65824 SD09093 SD12685 SD22964 SD22987 SD24454
Other clones	159753 273924 524191 bs08e10 bs46a03 bs46h10 CK01.20D.H10 CK01.66A.D11 EC23686 EK053616 EK262643 EN04932 FGM003B10 UUGC1005
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38232
Antibody Information
	polyclonal (Cutforth and Rubin, 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The activity of cdc2 is highly sensitive to Cdc37 levels, suggesting that the two genes may act in a common pathway to regulate cell cycle control. (Cutforth and Rubin, 1994) Mutants of Cdc37 display strong suppression of tor mutant embryos, embryos display 4 to 6 abdominal denticle belts. (Doyle and Bishop, 1993) Cdc37 is required for cell growth and viability. (Simon et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057658 RefSeq (Proteins) • NP_477006 DDBJ / EMBL / GenBank • AAA28414 AAF47571 AAO45184 AC005557 AF067899 AF067900 AI542663 AI945064 BI641789 BT004828 L32839 Entrez Gene - A searchable database of RefSeq genes. • 38232 UniProtKB/Swiss-Prot • Q24276 UniProtKB/TrEMBL • Q86NM8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cdc37 (IPR004918) Cdc37, N-terminal domain (IPR013855) Cdc37, C-terminal (IPR013873) Cdc37, Hsp90 binding (IPR013874)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63764 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011573 DroID - A comprehensive database of gene and protein interactions. • FBgn0011573 DRSC - Results from RNAi screens. • FBgn0011573 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011573 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12019-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011573 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38232 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38232 modMine - Data generated by the modENCODE project. • FBgn0011573
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	cdc37 (Richard et al., 2006, Tanentzapf et al., 2000, Colson, 1998.5.26, Colson, 1998.5.26, McVean and Vieira, 1999, Bhat et al., 1999, Hariharan et al., 1995, Kramer et al., 1995, Cutforth et al., 1993, Begemann et al., 1995, Nam and Choi, 2006, Mudiganti et al., 2010) Cdc37 (Djiane et al., 2005, Gresens and Cook, 2006.12.5, McDermott and Kliman, 2008, Dworkin et al., 2009, Neumüller et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Valakh et al., 2012) CG12019 (Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CPDR-1 (Colson and Goldstein, 1999) CPDR-2 (Colson and Goldstein, 1999) DROCPDR (Colson and Goldstein, 1999) E(sev)3B (Takahashi et al., 1996, Cutforth and Rubin, 1994, Yamamoto, 1993, Doyle and Bishop, 1993, Simon et al., 1991, )
Name Synonym	Cdc37   cdc37 protein (Cutforth, 1994.7.16)
Secondary FlyBase IDs
	FBgn0004640
References ( 65 )
Generate a list of	All references relating to this gene ( 65 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 6 ) Review  ( 2 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Valakh et al., 2012, Dev. Biol. 366(2): 163--171 A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. [FBrf0218359] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...