FB2022_03, released June 9, 2022

Gene: Dmel\Cdc37

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General Information
Symbol
Dmel\Cdc37
Species
D. melanogaster
Name
Cdc37
Annotation Symbol
CG12019
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011573
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Cdc37 (Cdc37) encodes a putative chaperone that inhibits Wnt and Hh signaling pathways. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

E(sev)3B

Key Links
Genomic Location
Cytogenetic map
62B4-62B4
Sequence location
Recombination map
3-1.0
RefSeq locus
NT_037436 REGION:1795392..1797307
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables insulin receptor binding
inferred from direct assay
(Huang and Wang, 2018)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables chaperone binding
non-traceable author statement
(assigned by UniProt )
(Cutforth and Rubin, 1994)
inferred from biological aspect of ancestor with PANTHER:PTN000980613
(assigned by GO_Central )
(Gaudet et al., 2011)
enables heat shock protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000980613
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein kinase binding
inferred from electronic annotation with InterPro:IPR013855
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein tyrosine kinase activator activity
non-traceable author statement
(assigned by UniProt )
(Cutforth and Rubin, 1994)
enables unfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000980613
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in positive regulation of ERK1 and ERK2 cascade
inferred from high throughput genetic interaction with FLYBASE:Dsor1; FB:FBgn0010269
(Ashton-Beaucage et al., 2014)
involved_in positive regulation of insulin receptor signaling pathway
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Huang and Wang, 2018)
involved_in positive regulation of neuroblast proliferation
inferred from mutant phenotype
(Huang and Wang, 2018)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in intracellular signal transduction
non-traceable author statement
(assigned by UniProt )
(Cutforth and Rubin, 1994)
involved_in protein folding
inferred from biological aspect of ancestor with PANTHER:PTN000980613
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein stabilization
inferred from biological aspect of ancestor with PANTHER:PTN000980613
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000980613
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:Q16543
(assigned by UniProt )
(Cutforth and Rubin, 1994)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the CDC37 family. (Q24276)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cdc37 (Cdc37) encodes a putative chaperone that inhibits Wnt and Hh signaling pathways. [Date last reviewed: 2018-09-13]
Pathway (FlyBase)
Positive Regulators of Insulin-like Receptor Signaling Pathway -
Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Protein Function (UniProtKB)
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis.
(UniProt, Q24276)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cdc37 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24276)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cdc37-RA
FBtr0072777
NM_057658
1611
389
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cdc37-PA
FBpp0072660
45.1
389
4.70
Q24276
NP_477006
AAF47571
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

389 (aa); 58 (kD observed); 45 (kD predicted)

(Cutforth and Rubin, 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Forms a complex with Hsp90. Interacts with a number of kinases such as Cdk1, sev and aurB.

(UniProt, Q24276)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc37 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism | ubiquitous
(Cutforth and Rubin, 1994)
late embryonic stage
organism | ubiquitous
(Cutforth and Rubin, 1994)
third instar larval stage
eye-antennal disc
(Cutforth and Rubin, 1994)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Cdc37 protein is ubiquitously distributed in the cytoplasm of cellularized embryos. It is also ubiquitously expressed in late embryos and third instar eye imaginal disc.

(Cutforth and Rubin, 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc37 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cdc37
Transgenic constructs containing regulatory region of Cdc37
Aberrations (Deficiencies and Duplications) ( 11 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Mef2.PR
lethal | recessive
lethal - all die before end of larval stage (with Cdc37e1C)
lethal - all die before end of larval stage (with Cdc37e1E)
lethal - all die before end of larval stage (with Cdc37e4D)
lethal - all die before end of larval stage (with Cdc37e6B)
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of second instar larval stage, with Df(3L)MY10
partially lethal, with Scer\GAL4tin.CΔ4
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal cell polarity | somatic clone, with Df(3L)MY10
abnormal cell shape | larval stage | conditional, with Scer\GAL4A58
abnormal cytokinesis (with Cdc37e1C)
abnormal cytokinesis (with Cdc37e1E)
abnormal cytokinesis (with Cdc37e4D)
abnormal cytokinesis (with Cdc37e6B)
abnormal meiotic cell cycle (with Cdc37e1C)
abnormal meiotic cell cycle (with Cdc37e1E)
abnormal meiotic cell cycle (with Cdc37e4D)
abnormal meiotic cell cycle (with Cdc37e6B)
abnormal neuroanatomy | larval stage
abnormal size | larval stage, with Scer\GAL4A58
abnormal wound healing | larval stage, with Scer\GAL4A58
decreased cell size | larval stage | conditional, with Scer\GAL4A58
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage (with Cdc37e1C)
some die during larval stage (with Cdc37e1E)
some die during larval stage (with Cdc37e4D)
some die during larval stage (with Cdc37e6B)
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during second instar larval stage, with Df(3L)MY10
wild-type
Phenotype manifest in
Allele
actomyosin contractile ring (with Cdc37e1C)
actomyosin contractile ring (with Cdc37e1E)
actomyosin contractile ring (with Cdc37e4D)
actomyosin contractile ring (with Cdc37e6B)
adult abdomen
anaphase & condensed nuclear chromosome (with Cdc37e1C)
anaphase & condensed nuclear chromosome (with Cdc37e1E)
anaphase & condensed nuclear chromosome (with Cdc37e4D)
anaphase & condensed nuclear chromosome (with Cdc37e6B)
embryonic/larval epidermis | larval stage, with Scer\GAL4A58
embryonic/larval epidermis | larval stage | conditional, with Scer\GAL4A58
eye photoreceptor cell | somatic clone, with Df(3L)MY10
ganglion mother cell | larval stage
larval neuroblast | larval stage
nucleus | larval stage, with Scer\GAL4A58
ommatidium | somatic clone, with Df(3L)MY10
rhabdomere, with Df(3L)MY10
rhabdomere | somatic clone, with Df(3L)MY10
spermatid (with Cdc37e1C)
spermatid (with Cdc37e1E)
spermatid (with Cdc37e4D)
spermatid (with Cdc37e6B)
spindle (with Cdc37e1C)
spindle (with Cdc37e1E)
spindle (with Cdc37e4D)
spindle (with Cdc37e6B)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDC37
13 of 15
Yes
Yes
1  
Hsap\CDC37L1
7 of 15
No
Yes
Hsap\MIR1181
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdc37
13 of 15
Yes
Yes
Mmus\Cdc37l1
7 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Cdc37
12 of 13
Yes
Yes
Rnor\Cdc37l1
7 of 13
No
Yes
Rnor\Atp5f1b
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\cdc37
13 of 12
Yes
Yes
Xtro\cdc37l1
7 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\cdc37
8 of 15
Yes
Yes
Drer\cdc37l1
8 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\cdc-37
14 of 15
Yes
Yes
Cele\K07E8.6
7 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CDC37
10 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cdc37
8 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CDC37; cell division cycle 37, HSP90 cochaperone
    13 of 15
    605065
         
        CDC37L1; cell division cycle 37 like 1, HSP90 cochaperone
        7 of 15
        610346
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Rho1
            suppressible
            Cdc37
            (Hariharan et al., 1995)
            sev
            enhanceable
            Cdc37
            (Simon et al., 1991)
            External Data
            Subunit Structure (UniProtKB)
            Forms a complex with Hsp90. Interacts with a number of kinases such as Cdk1, sev and aurB.
            (UniProt, Q24276 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Positive Regulators of Insulin-like Receptor Signaling Pathway -
            Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
            Metabolic Pathways
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-1.0
            Cytogenetic map
            62B4-62B4
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            62B4-62B4
            Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            62B4-62B5
            (Cutforth, 1994.7.16)
            Experimentally Determined Recombination Data
            Location

            3-1.0

            (FlyBase, 2016)

            3-2.7

            (Comeron et al., 2012)

            3-5

            (Simon et al., 1991)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (10)
            Genomic Clones (12)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (60)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Lee et al., 2019, Cutforth and Rubin, 1994)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of
            Additional comments
            Other Comments

            The activity of cdc2 is highly sensitive to Cdc37 levels, suggesting that the two genes may act in a common pathway to regulate cell cycle control.

            (Cutforth and Rubin, 1994)

            Mutants of Cdc37 display strong suppression of tor mutant embryos, embryos display 4 to 6 abdominal denticle belts.

            (Doyle and Bishop, 1993)

            Cdc37 is required for cell growth and viability.

            (Simon et al., 1991)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 46 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (8)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            References (103)