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Gene Dmel\Iswi

General Information
Symbol	Dmel\Iswi	Species	D. melanogaster
Name	Imitation SWI	Annotation symbol	CG8625
Feature type	protein_coding_gene	FlyBase ID	FBgn0011604
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	NURF, CHRAC, ACF, dNURF, dISWI, dCHRAC
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49B10-49B10	Sequence location	2R:8,524,123..8,528,133 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; nucleosome-dependent ATPase activity; DNA-dependent ATPase activity. There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; chromatin organization; organelle organization; regulation of cellular macromolecule biosynthetic process; cellular macromolecular complex subunit organization; anatomical structure development; cellular macromolecule metabolic process; gene expression; regulation of metabolic process. 18 alleles are reported. The phenotypes of these alleles are annotated with: eye; wing disc; mechanosensory chaeta; polytene chromosome; dorsocentral bristle; euchromatin; mesothoracic tergum; condensed chromosome. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: ATPase, nucleosome remodelling ISWI, HAND domain; DEAD-like helicase; Helicase, C-terminal; Homeodomain-like; SANT domain, DNA binding; SANT, eukarya; SLIDE; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641309_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Iswi. Gene sequence location is 2R:8524123..8528133.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Kirilly et al., 2011, Neuron 72(1): 86--100 Sequence features BKN20457 HFA07446 Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter transcription factor binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49B10-49B10   Limits computationally determined from genome sequence between P{EP}AmphEP2175&P{lacW}spt4k05316 and P{PZ}ox1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49B-49C     (Elfring, 1994.7.19) 49B-49C   (determined by in situ hybridisation)   (Elfring et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Iswi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Iswi-RA FBtr0087841  NM_078995   3700   1027 Iswi-RB FBtr0087842  NM_165930   3556   1027 Iswi-RC FBtr0087843  NM_165931   3535   1027
Additional Transcript Data & Comments
Reported size (kB)	3.6 (northern blot) (Elfring et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Iswi-PA   FBpp0086954   118.9   1027   8.51     NP_523719   AAF58479 Iswi-PB   FBpp0086955   118.9   1027   8.51     NP_725203   AAM68637 Iswi-PC   FBpp0086956   118.9   1027   8.51     NP_725204   AAM68638
Additional Polypeptide Data & Comments
Reported size (kDa)	1027 (aa); 119 (kD predicted) (Elfring et al., 1994) 140 (kD) (Tsukiyama et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) SANT domain, DNA binding (IPR001005) Helicase, C-terminal (IPR001650) Homeodomain-like (IPR009057) DEAD-like helicase (IPR014001) ATPase, nucleosome remodelling ISWI, HAND domain (IPR015194) SLIDE (IPR015195) SANT, eukarya (IPR017884)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201120   AA201296   AA201495   AA391704   AA439535   AA440104   AA440995   AA567122   AA696149   AA697243   AA820897   AA950111   AA951778   AE013599 AAF58479   AE013599 AAM68637   AE013599 AAM68638   AI108812   AI109405   AI456584   AI512664   AI518321   AI518602   AI531064   AI531151   AI533058   AX683150   AY094908 AAM11261   AZ300947   BF496004   BF500189   BG639137   BH840518   BI162946   BI162971   BI167010   BI168901   BI170413   BI171416   BI171656   BI172739   BI216776   BI231530   BI231922   BI234045   BI235918   BI243358   BI352793   BI353760   BI354462   BI366398   BI368572   BI372234   BI485932   BI607064   BI608595   BI621218   BI623303   BI630628   BI633522   BT044562   CA806406   CO186130   CO275410   CO276149   CO278500   CO282995   CO287076   CO289316   CO290144   CO298200   CO307762   CO321853   CO330321   CO332904   CO333097   CZ488977   EC051113   EC053148   EC053632   EC056403   EC060680   EC068220   EC070290   EC076552   EC078938   EC079343   EC082900   EC085242   EC203950   EC205309   EC210038   EC213742   EC217014   EC217015   EC217225   EC219059   EC222644   EC230504   EC238109   EC245483   EC246271   EV582450   GH747866   GH753282   GH753431   GH757593   GH758164   GH758327   GH760760   GH771251   GH774802   GH775088   GH775130   GH776152   GH777930   GH784568   GH793209   GH793373   GH799144   GH802113   GH802610   GH803345   GH804139   GH805569   GH806556   GH807851   GH810549   GH812352   GH815366   GH821791   GH822520   GH825007   GH825813   GH825850   GH826019   GH831518   GH835271   GH835602   GH836054   GH843848   GH848779   GH854391   GH857341   GH857569   GH859844   GH861225   GH864348   GH865326   GH866329   GH867936   GH876228   GH880236   GH880832   GH883233   GH883696   GH883728   GH884641   GH885016   GH885838   GH888478   GH891964   GH898127   GH898910   GH904272   GH913584   GH914453   GH918300   GH925769   GH926165   GH930963   GH931097   GH935318   GH936299   GH941572   GH944720   GH944740   GH945211   GH945344   GH946737   GH946958   GH948630   GH949268   GH950450   GH950841   GH951840   GH952197   GH952544   GH953033   GH953885   GH955658   GH956590   GH958593   GH959144   GH962538   GH962691   GH962930   GH966770   GH968908   GH970615   GH972811   GH973794   GH975713   GH976225   GH977479   GH978458   GH979720   GH979843   GH980135   GH980608   GH982572   GH983035   GH983837   GH984571   L27127 AAA19868
UniProtKB/Swiss-Prot	Q24368
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 12   organism | ubiquitous & uniform   (Elfring et al., 1994) embryonic stage 13 -- 17   embryonic/larval central nervous system   (Elfring et al., 1994) gonad   (Elfring et al., 1994) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- pupal stage     (Elfring et al., 1994) embryonic stage 1 -- 12   organism   (Elfring et al., 1994) embryonic stage 1 -- 15   organism | intense   (Elfring et al., 1994) embryonic stage 13 -- 17   gonad   (Elfring et al., 1994) presumptive embryonic/larval central nervous system   (Elfring et al., 1994) embryonic stage 16 -- third instar larval stage   organism | faint   (Elfring et al., 1994) P-stage   organism   (Elfring et al., 1994) adult stage | female     (Elfring et al., 1994) organism | faint   (Elfring et al., 1994) oogenesis   oocyte   (Elfring et al., 1994)
Additional Descriptive Data
	The pattern of Iswi and brm transcript expression are very similar. Iswi transcript levels are highest in oocytes and early embryos, and lower in late embryos and larvae. Iswi is barely detected in pupae and adult females, but is not detected in adult males. In embryos, both Iswi and brm transcripts are uniformly distributed until germ band retraction. Both gradually become restricted to the central nervous system and are undetectable near hatching. Unlike brm, Iswi transcripts are also detected in gonads after germ band retraction. (Elfring et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Tsukiyama et al., 1995, Ito et al., 1999)
Additional Descriptive Data
	Iswi protein is detected in all nuclei of embryos, as well as in diploid and polyploid nuclei of third instar larvae. (Ito et al., 1999, Tsukiyama et al., 1995) Iswi protein is detected in all developmental stages. It is at highest levels in mid-embryogenesis, with lower levels in larvae, pupae, and adults. Expression in adult males is ~50-fold lower than in 0-12 hr embryos. Expression in the developing embryo can be as high as 100,000 molecules of Iswi protein per cell. (Tsukiyama et al., 1995)
Marker for
Subcellular Localization
CV Term	nucleus (Tsukiyama et al., 1995)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011604    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011604 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011604 expression level Developmental Stage   Expression Level embryo 00-02hr    5233 embryo 02-04hr    10953 embryo 04-06hr    18364 embryo 06-08hr    11785 embryo 08-10hr    8587 embryo 10-12hr    3981 embryo 12-14hr    3761 embryo 14-16hr    2640 embryo 16-18hr    2113 embryo 18-20hr    1041 embryo 20-22hr    2939 embryo 22-24hr    2710 larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6    1943 larva L3 puffstage 7-9    2480 white prepupae new    2490 white prepupae 12hr    3083 white prepupae 24hr    3742 pupae 2d postWPP    2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day    1954 adult male 30day    1728 adult female 01day    1479 adult female 05day    3032 adult female 30day    2895 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5233) embryo 02-04hr  (10953) embryo 04-06hr  (18364) embryo 06-08hr  (11785) embryo 08-10hr  (8587) embryo 10-12hr  (3981) embryo 12-14hr  (3761) embryo 14-16hr  (2640) embryo 16-18hr  (2113) embryo 18-20hr  (1041) embryo 20-22hr  (2939) embryo 22-24hr  (2710) larva L1  (1076) larva L2  (884) larva L3 12hr old  (692) larva L3 puffstage 1-2  (1176) larva L3 puffstage 3-6  (1943) larva L3 puffstage 7-9  (2480) white prepupae new  (2490) white prepupae 12hr  (3083) white prepupae 24hr  (3742) pupae 2d postWPP  (2353) pupae 3d postWPP  (1211) pupae 4d postWPP  (862) adult male 01day  (1354) adult male 05day  (1954) adult male 30day  (1728) adult female 01day  (1479) adult female 05day  (3032) adult female 30day  (2895) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5233) embryo 02-04hr  (10953) embryo 04-06hr  (18364) embryo 06-08hr  (11785) embryo 08-10hr  (8587) embryo 10-12hr  (3981) embryo 12-14hr  (3761) embryo 14-16hr  (2640) embryo 16-18hr  (2113) embryo 18-20hr    1041 embryo 20-22hr  (2939) embryo 22-24hr  (2710) larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6  (1943) larva L3 puffstage 7-9  (2480) white prepupae new  (2490) white prepupae 12hr  (3083) white prepupae 24hr  (3742) pupae 2d postWPP  (2353) pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day  (1954) adult male 30day  (1728) adult female 01day  1479 adult female 05day  (3032) adult female 30day  (2895) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5233 embryo 02-04hr  (10953) embryo 04-06hr  (18364) embryo 06-08hr  (11785) embryo 08-10hr    8587 embryo 10-12hr    3981 embryo 12-14hr    3761 embryo 14-16hr    2640 embryo 16-18hr    2113 embryo 18-20hr    1041 embryo 20-22hr    2939 embryo 22-24hr    2710 larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6    1943 larva L3 puffstage 7-9    2480 white prepupae new    2490 white prepupae 12hr    3083 white prepupae 24hr    3742 pupae 2d postWPP    2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day    1954 adult male 30day    1728 adult female 01day    1479 adult female 05day    3032 adult female 30day    2895 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5233 embryo 02-04hr    10953 embryo 04-06hr    18364 embryo 06-08hr    11785 embryo 08-10hr    8587 embryo 10-12hr    3981 embryo 12-14hr    3761 embryo 14-16hr    2640 embryo 16-18hr    2113 embryo 18-20hr    1041 embryo 20-22hr    2939 embryo 22-24hr    2710 larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6    1943 larva L3 puffstage 7-9    2480 white prepupae new    2490 white prepupae 12hr    3083 white prepupae 24hr    3742 pupae 2d postWPP    2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day    1954 adult male 30day    1728 adult female 01day    1479 adult female 05day    3032 adult female 30day    2895 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011604 expression level Developmental Stage   Expression Level embryo 00-02hr    5233 embryo 02-04hr    10953 embryo 04-06hr    18364 embryo 06-08hr    11785 embryo 08-10hr    8587 embryo 10-12hr    3981 embryo 12-14hr    3761 embryo 14-16hr    2640 embryo 16-18hr    2113 embryo 18-20hr    1041 embryo 20-22hr    2939 embryo 22-24hr    2710 larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6    1943 larva L3 puffstage 7-9    2480 white prepupae new    2490 white prepupae 12hr    3083 white prepupae 24hr    3742 pupae 2d postWPP    2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day    1954 adult male 30day    1728 adult female 01day    1479 adult female 05day    3032 adult female 30day    2895 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5233) embryo 02-04hr  (10953) embryo 04-06hr  (18364) embryo 06-08hr  (11785) embryo 08-10hr  (8587) embryo 10-12hr  (3981) embryo 12-14hr  (3761) embryo 14-16hr  (2640) embryo 16-18hr  (2113) embryo 18-20hr  (1041) embryo 20-22hr  (2939) embryo 22-24hr  (2710) larva L1  (1076) larva L2  (884) larva L3 12hr old  (692) larva L3 puffstage 1-2  (1176) larva L3 puffstage 3-6  (1943) larva L3 puffstage 7-9  (2480) white prepupae new  (2490) white prepupae 12hr  (3083) white prepupae 24hr  (3742) pupae 2d postWPP  (2353) pupae 3d postWPP  (1211) pupae 4d postWPP  (862) adult male 01day  (1354) adult male 05day  (1954) adult male 30day  (1728) adult female 01day  (1479) adult female 05day  (3032) adult female 30day  (2895) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5233) embryo 02-04hr  (10953) embryo 04-06hr  (18364) embryo 06-08hr  (11785) embryo 08-10hr  (8587) embryo 10-12hr  (3981) embryo 12-14hr  (3761) embryo 14-16hr  (2640) embryo 16-18hr  2113 embryo 18-20hr    1041 embryo 20-22hr  (2939) embryo 22-24hr  (2710) larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6  1943 larva L3 puffstage 7-9  (2480) white prepupae new  (2490) white prepupae 12hr  (3083) white prepupae 24hr  (3742) pupae 2d postWPP  2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day  1954 adult male 30day  1728 adult female 01day  1479 adult female 05day  (3032) adult female 30day  (2895) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5233 embryo 02-04hr  10953 embryo 04-06hr  18364 embryo 06-08hr  11785 embryo 08-10hr    8587 embryo 10-12hr    3981 embryo 12-14hr    3761 embryo 14-16hr    2640 embryo 16-18hr    2113 embryo 18-20hr    1041 embryo 20-22hr    2939 embryo 22-24hr    2710 larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6    1943 larva L3 puffstage 7-9    2480 white prepupae new    2490 white prepupae 12hr    3083 white prepupae 24hr    3742 pupae 2d postWPP    2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day    1954 adult male 30day    1728 adult female 01day    1479 adult female 05day    3032 adult female 30day    2895 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5233 embryo 02-04hr    10953 embryo 04-06hr    18364 embryo 06-08hr    11785 embryo 08-10hr    8587 embryo 10-12hr    3981 embryo 12-14hr    3761 embryo 14-16hr    2640 embryo 16-18hr    2113 embryo 18-20hr    1041 embryo 20-22hr    2939 embryo 22-24hr    2710 larva L1    1076 larva L2    884 larva L3 12hr old    692 larva L3 puffstage 1-2    1176 larva L3 puffstage 3-6    1943 larva L3 puffstage 7-9    2480 white prepupae new    2490 white prepupae 12hr    3083 white prepupae 24hr    3742 pupae 2d postWPP    2353 pupae 3d postWPP    1211 pupae 4d postWPP    862 adult male 01day    1354 adult male 05day    1954 adult male 30day    1728 adult female 01day    1479 adult female 05day    3032 adult female 30day    2895 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011604    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011604 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011604 expression level Tissue   Expression Level Larval Central Nervous System    787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (787.3) Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011604 expression level Tissue   Expression Level Larval Central Nervous System    787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    787.3 Larval Midgut    80.2 Larval Hindgut    116 Larval Malpighian Tubules    147.6 Larval Fat Body    110.5 Larval Salivary Gland    178 Larval Trachea    208.25 Larval Carcass    129.525 Adult Head    88.4 Adult Eye    120.05 Adult Brain    272.5 Adult Thoracic-Abdominal Ganglion    234.6 Adult Crop    90.9 Adult Midgut    86.5 Adult Hindgut    95.8 Adult Malpighian Tubules    98.2 Adult Fat Body    51.6 Adult Salivary Gland    122.1 Adult Heart    58.275 Adult VirginFemale Spermatheca    37.1 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    427.5 Adult Testis    340.6 Adult Male Accessory Gland    63.4 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    88.4   NA  Eye    120.05   NA  Brain    272.5   787.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    234.6   NA  Crop    90.9   80.2  Midgut    86.5   116  Hindgut    95.8   147.6  Malpighian Tubules    98.2   110.5  Fat Body    51.6   178  Salivary Gland    122.1   NA  Heart    58.275   208.25  Trachea    NA   NA  VirginFemale Spermatheca    37.1   NA  InseminatedFemale Spermatheca    36.7   NA  Ovary    427.5   NA  Testis    340.6   NA  Male Accessory Gland    63.4   129.525  Carcass    43.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011604 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8625-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Iswi Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Iswi1 Iswi2 lethal, with Iswi2 Iswi1 lethal, with Scer\GAL469B IswiK159R.Scer\UAS.T:Ivir\HA1 lethal, with Scer\GAL41407 IswiGD1467 lethal | heat sensitive, with Iswi2, Scer\GAL4da.G32 IswiK159R.Scer\UAS.T:Ivir\HA1 lethal | heat sensitive, with IswiK159R.Scer\UAS.T:Ivir\HA1, Scer\GAL4da.G32 Iswi2 lethal | larval stage, with Iswi1 Iswi2 lethal | larval stage, with Iswi2 Iswi1 lethal | larval stage (with Iswi1) Iswi2 lethal | larval stage (with Iswi2) Iswi1 lethal | recessive Iswi1 Iswi2 viable, with Scer\GAL4pnr-MD237 IswiGD1467 Sterility Allele female sterile Iswi2 Other Phenotypes Allele eye color defective | somatic clone Iswi2 locomotor rhythm defective, with Scer\GAL4tim.Scer\UAS IswidsRNA.Scer\UAS mitotic cell cycle defective Iswi2 non-enhancer of variegation, with In(1)wm4 Iswiunspecified non-suppressor of variegation, with In(1)wm4 Iswiunspecified tumorigenic Iswi1 Iswi2 visible, with Iswi2, Scer\GAL4ey.PH IswiK159R.Scer\UAS.T:Ivir\HA1 visible, with IswiK159R.Scer\UAS.T:Ivir\HA1, Scer\GAL4ey.PH Iswi2 visible, with Scer\GAL4ey.PH IswiK159R.Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4pnr-MD237 IswiGD1467 visible, with Scer\GAL4sca-537.4 IswiK159R.Scer\UAS.T:Ivir\HA1 visible | somatic clone Iswi2 wild-type Iswi+t12 IswiT:Ivir\HA1 Phenotype manifest in Allele adult head | somatic clone Iswi2 adult thoracic segment | somatic clone Iswi2 condensed chromosome, with Iswi2, Scer\GAL4da.G32 IswiK159R.Scer\UAS.T:Ivir\HA1 condensed chromosome, with IswiK159R.Scer\UAS.T:Ivir\HA1, Scer\GAL4da.G32 Iswi2 condensed chromosome, with Scer\GAL4da.G32 IswiK159R.Scer\UAS.T:Ivir\HA1 dorsocentral bristle Iswi2 dorsocentral bristle, with Scer\GAL4pnr-MD237 IswiK159R.Scer\UAS.T:Ivir\HA1 embryonic/larval brain | larval stage, with Scer\GAL41407 IswiGD1467 embryonic/larval hemocyte | supernumerary Iswi1 Iswi2 euchromatin, with Scer\GAL4da.G32 IswiK159R.Scer\UAS.T:Ivir\HA1 eye, with Iswi2, Scer\GAL4ey.PH IswiK159R.Scer\UAS.T:Ivir\HA1 eye, with IswiK159R.Scer\UAS.T:Ivir\HA1, Scer\GAL4ey.PH Iswi2 eye, with Scer\GAL4ey.PH IswiK159R.Scer\UAS.T:Ivir\HA1 eye | somatic clone Iswi2 eye photoreceptor cell | somatic clone Iswi2 female germline stem cell | germline clone Iswi1 Iswi2 follicle stem cell | somatic clone Iswi2 genitalia | somatic clone Iswi2 hemocyte | supernumerary, with Iswi1 Iswi2 hemocyte | supernumerary, with Iswi2 Iswi1 mechanosensory chaeta, with Scer\GAL4sca-537.4 IswiK159R.Scer\UAS.T:Ivir\HA1 mesothoracic tergum, with Scer\GAL4pnr-MD237 IswiGD1467 ommatidium | somatic clone Iswi2 ovariole | germline clone Iswi2 polytene chromosome Iswi1 Iswi2 polytene chromosome, with Scer\GAL4ey.PH IswiK159R.Scer\UAS.T:Ivir\HA1 polytene chromosome (with Iswi1) Iswi2 polytene chromosome (with Iswi2) Iswi1 polytene chromosome | male, with Iswi1 Iswi2 polytene chromosome | male, with Iswi2 Iswi1 polytene chromosome | male limited (with Iswi1) Iswi2 polytene chromosome | male limited (with Iswi2) Iswi1 wing disc, with Iswi1 Iswi2 wing disc, with Iswi2 Iswi1 X chromosome | male Iswi2
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Iswi Class Mutagen Stocks Known lesion IswiEP2413 P-element activity 1 -- IswiKG03354 P-element activity 1 -- Iswi1 loss of function allele ethyl methanesulfonate 0 Yes Iswi2 loss of function allele ethyl methanesulfonate 0 Yes Iswif06295 piggyBac transposase 0 -- Iswiunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Iswi Class Mutagen Stocks Known lesion IswiGD1467 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes IswiHMS00628 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IswiJF01582 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Iswi+t12 in vitro construct - genomic fragment 0 Yes IswidsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes IswiK159R.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes IswiK159R.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes IswiScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes IswiScer\UAS.T:Zzzz\TAP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes IswiT:Ivir\HA1 in vitro construct - coding region fusion 0 Yes IswitBR5 in vitro construct - genomic fragment 0 Yes IswitBR7 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7121 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1467} NA P{TRiP.HMS00628} NA P{TRiP.JF01582} NA P{UAS-Iswi.HA} NA P{UAS-Iswi.IR} NA P{UAS-Iswi.K159R} NA P{UAS-Iswi.TAP} NA characterization construct P{Iswi+.B12} NA P{IswiK159R.T:Ivir\HA1} NA P{IswiT:Ivir\HA1} NA P{IswitBR5} NA P{IswitBR7} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}IswiKG03354 NA PBac{WH}Iswif06295 NA insertion of mobile activating element P{EP}IswiEP2413 NA
Gene Ontology: Function, Process & Cellular Component ( 37 unique terms )
Terms Based on Experimental Evidence ( 26 terms )
Molecular Function
CV term Evidence References
DNA-dependent ATPase activity inferred from direct assay (Varga-Weisz et al., 1997, Hamiche et al., 1999, Fyodorov and Kadonaga, 2002) inferred from direct assay AND inferred from genetic interaction with His3 AND inferred from genetic interaction with His4 (Georgel et al., 1997) nucleosome-dependent ATPase activity inferred from direct assay (Burgio et al., 2008) protein binding inferred from physical interaction with Acf1 (Fyodorov and Kadonaga, 2002) inferred from physical interaction with Chi (Vanolst et al., 2005) inferred from physical interaction with Chrac-14 (Corona et al., 2000) inferred from physical interaction with Chrac-14, Chrac-16 (Corona et al., 2000) inferred from physical interaction with tou (Vanolst et al., 2005) transcription factor binding inferred from physical interaction with pnr (Vanolst et al., 2005)
Biological Process
CV term Evidence References
chromatin assembly or disassembly inferred from direct assay (Mizuguchi et al., 1997) chromatin organization inferred from mutant phenotype (Corona et al., 2007) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) ecdysone receptor-mediated signaling pathway inferred from genetic interaction with EcR (Badenhorst et al., 2005) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Liu et al., 2008) nuclear speck organization inferred from mutant phenotype (Onorati et al., 2011) nucleosome assembly inferred from direct assay (Ito et al., 1997, Ito et al., 1999) nucleosome mobilization inferred from direct assay (Hamiche et al., 1999, Eberharter et al., 2001, Langst and Becker, 2001) nucleosome positioning inferred from direct assay (Ito et al., 1997, Varga-Weisz et al., 1997) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Vanolst et al., 2005) regulation of circadian rhythm inferred from mutant phenotype (Matsumoto et al., 2007) regulation of transcription, DNA-dependent inferred from direct assay (Ito et al., 1997) inferred from mutant phenotype (Corona et al., 2007) transcription, DNA-dependent inferred from direct assay (Mizuguchi et al., 2001)
Cellular Component
CV term Evidence References
ACF complex inferred from direct assay (Ito et al., 1997, Ito et al., 1999) NOT brahma complex inferred from direct assay (Kal et al., 2000) chromatin accessibility complex inferred from direct assay (Varga-Weisz et al., 1997, Eberharter et al., 2001) nucleus inferred from direct assay (Tsukiyama et al., 1995) NURF complex inferred from direct assay (Tsukiyama et al., 1995) polytene chromosome inferred from direct assay (Hanai et al., 2008, Burgio et al., 2008) RSF complex inferred from physical interaction with CG8677 (Hanai et al., 2008) transcription factor complex inferred from physical interaction with Trf2 (Hochheimer et al., 2002)
Terms Based on Predictions or Assertions ( 16 terms )
Molecular Function
CV term Evidence References
ATPase activity non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) ATP binding inferred from sequence or structural similarity with Saccharomyces SNF2 (Tsukiyama et al., 1995) DNA binding inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR001005 (FlyBase Curators et al., 2004-) DNA helicase activity traceable author statement (Brehm et al., 2000) helicase activity inferred from electronic annotation with InterPro:IPR001650 (FlyBase Curators et al., 2004-) nucleosome binding inferred from electronic annotation with InterPro:IPR015194 (FlyBase Curators et al., 2004-) nucleotide binding traceable author statement (Ito et al., 1997)
Biological Process
CV term Evidence References
ATP-dependent chromatin remodeling inferred from electronic annotation with InterPro:IPR015194 (FlyBase Curators et al., 2004-) chromatin assembly or disassembly traceable author statement (Lusser and Kadonaga, 2003) chromatin remodeling inferred from sequence or structural similarity with Saccharomyces SNF2 (Elfring et al., 1994) non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) traceable author statement (Brehm et al., 2000, Lusser and Kadonaga, 2003) nucleosome mobilization traceable author statement (Lusser and Kadonaga, 2003) positive regulation of transcription, DNA-dependent traceable author statement (Badenhorst et al., 2002)
Cellular Component
CV term Evidence References
ACF complex non-traceable author statement (Swiss-Prot Project Members, 1999.12.15, Lusser and Kadonaga, 2003) traceable author statement (Badenhorst et al., 2002) chromatin accessibility complex non-traceable author statement (Swiss-Prot Project Members, 1999.12.15, Lusser and Kadonaga, 2003) traceable author statement (Badenhorst et al., 2002) chromatin remodeling complex inferred from sequence or structural similarity with Saccharomyces SNF2 (FlyBase, 1992-) NURF complex non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) traceable author statement (Ito et al., 1997, Badenhorst et al., 2002, Gdula et al., 1998, Lusser and Kadonaga, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Iswi allele Gene References Iswi1 Acf1 (Fyodorov et al., 2004) Iswi2 Acf1 (Fyodorov et al., 2004) unspecified EcR (Badenhorst et al., 2005) RpII215 (Armstrong et al., 2005) scf (Furuhashi et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62163 DroID - A comprehensive database of gene and protein interactions. • FBgn0011604 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36390
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13400 Dere\GG20326 Dgri\GH23147 Dmoj\GI18485 Dper\GL11075 Dpse\GA21216 Dsec\GM21414 Dsim\GD10909 Dvir\GJ21347 Dwil\GK21565 Dyak\GE12485
Curated drosophilid orthologs	Dpse\GA21216
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003968-PA Aedes aegypti (mosquito) AGAP010700-PA Anopheles gambiae (mosquito) XP_396195.2 Apis mellifera (honey bee) XP_001945595.1 Acyrthosiphon pisum (pea aphid) At3g06400.1 Arabidopsis thaliana (wall cress) At5g18620.2 Arabidopsis thaliana (wall cress) 17244 Batrachochytrium dendrobatidis (chytrid fungus) XP_001891999.1 Brugia malayi (roundworm nematode) BGIBMGA000930-PA Bombyx mori (silk worm) ENSBTAP00000004408 Bos taurus (bovine) CAL0001816 Candida albicans (a form of yeast) CN08163 Caenorhabditis brenneri (small nematode) CBP32890 Caenorhabditis briggsae (nematode) CE29792 Caenorhabditis elegans (worm) ENSCAFP00000011181 Canis familiaris (dog) CAGL0I09614g Candida glabrata (haploid yeast) Chro.60441 Cryptosporidium hominis (obligate parasite) ENSCINP00000008494 Ciona intestinalis (sea squirt) JA15722 Caenorhabditis japonica (nematode) CMQ363C Cyanidioschyzon merolae (red alga) cn12203 Cryptococcus neoformans (yeast-like fungus) cgd6_3860 Cryptosporidium parvum (protozoan parasite) CPIJ011038 Culex pipens (mosquito) ENSCPOP00000002050 Cavia porcellus (guinea pig) 135484 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000007729 Ciona savignyi (sedentary tunicate) 18898 Capitella spl (polychaete worm) DDB0231763 Dictyostelium discoideum (amoeba) DEHA2C08294g Debaryomyces Hansenii (yeast) 318579 Daphnia pulex (daphnia) ENSDARP00000023313 Danio rerio (zebra fish) ENSECAP00000004410 Equus caballus (horse) XP_657207 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022775 Gymnopilus aculeatus (mushroom) ENSGALP00000013722 Gallus gallus (chicken) GL50803_8228 Giardia lamblia (flagellated protozoan) 101736 Hypsipyla robusta (cedar shoot borer) ENSP00000283131 Homo sapiens (human) ISCW023393-PA Ixodes scapularis (deer tick) KLLA0F24838g Kluyveromyces lactis (yeast) 182249 Lottia gigantea (owl limpet) LmjF33.1700 Leishmania major (virus) 14315 Monocosta brevicollis (choanoflagellate) ENSMODP00000000470 Monodelphis domestica (gray opossum) ENSMMUP00000001125 Macaca mulatta (rhesus monkey) ENSMUSP00000044361 Mus musculus (house mouse) 226879 Nematostella vectensis (starlet anemone) XP_001601734.1 Nasonia vitripennis (wasp) ENSOANP00000004550 Ornithorynchus anatinus (platypus) LOC_Os01g27040.1 Oryza sativa (asian rice) 34063 Ostreococcus tauri (green alga) PF11_0053 Plasmodium falciparum (protozoal parasite) PHUM004414-PA Pediculus humanus (human body louse) PP02251 Pristionchus pacificus (nematode) 216086 Physcomitrella patens (moss) ENSPPYP00000016857 Pongo pygmaeus (orangutan) 80013 Phytophthora ramorum (sudden oak death pathogen) 119019 Phytophthora sojae (root rot pathogen) 229734 Populus trichocarpa (black cottonwood) ENSPTRP00000028278 Pan troglodytes (chimpanzee) PVX_090890 Plasmodium vivax (protozoal parasite) ENSRNOP00000024568 Rattus norvegicus (norway rat) 5053112 Sorghum bicolor (sorghum) YOR304W Saccharomyces cerevisiae (budding yeast) Smp_008830 Schistosoma mansoni (trematode parasite) XP_001176374.1 Strongylocentrotus purpuratus (purple sea urchin) 60972 Trichoplax adhaerens (metazoa) TA06490 Theileria annulata (apicomplexan parasite) XP_972116.1 Tribolium castaneum (red flour beetle) Tc00.1047053509213.170 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020867 Tetraodon nigroviridis (green spotted pufferfish) TP01_0936 Theileria parva (parasitic protozoan) 12403 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036061 Takifugu rubripes (pufferfish Takifugu) 3698.m00154 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000038157 Xenopus tropicalis (frog) YALI0E02332g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15374 LH16817 ISCW023393 ISCW010946 FBgn0230228 FBgn0223557 FBgn0208477 FBgn0208475 FBgn0182672 FBgn0176295 JGI_V11_318579 FBgn0081204 FBgn0148685 FBgn0141224 FBgn0130604 FBgn0112517 FBgn0090432 CPIJ011038 BGIBMGA000930 ACYPI006575 ACYPI004047 ACYPI001312 GB14577 AGAP010700 AAEL003968 PB24926 PHUM614620 GLEAN_07199
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31111 y1 v1; P{TRiP.JF01582}attP2 14265 y1 w67c23; P{SUPor-P}IswiKG03354 32845 y1 sc* v1; P{TRiP.HMS00628}attP2/TM3, Sb1
Kyoto	122051 w1118; P{EP}IswiEP2413
VDRC	v6208 w1118; P{GD1467}v6208 v24505 w1118; P{GD1467}v24505
Genomic Clones ( 1 )
	BACR27F05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 202 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH13158
Other clones	FI04427
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09707 AT14940 GH08103 GH08587 GM01149 GM05168 GM09513 GM20823 GM25021 GM26914 LD03686 LD04238 LD04574 LD11629 LD14126 LD15186 LD15719 LD24831 LD28644 LD32493 LD36651 LD37802 LD38212 RE02227 RE02256 RE07277 RE09807 RE11846 RE13189 RE13476 RE15410 RE22406 RE24027 RE25104 RE29674 RE31874 RE40972 RE51926 RE54564 RE59147 RE69291 RH52527 RH55428 RH59908 RH74052 SD01940 SD02071 SD04746 SD27632
Other clones	14869 17806 45414 48108 51181 60230 103618 105997 149617 160065 192250 277321 280938 CK01.16A.G6 CK01.82B.G11 CK01.89D.C12 CK01.93D.F2 CK01.113A.A6 CK01.145D.D7 Dmel_dig_018727_0584_1922 EC051113 EC053148 EC053632 EC056403 EK016059 EK064828 EK070742 EK073153 EK117528 EK119816 EK130216 EK161951 EK172522 EK186533 EK255535 EK294954 EK305105 EK305658 ESG013a.E21.1_H02 LD44594 RP003011862 RP003032258 RP003037323 RP003040324 RP003054235 RP003054257 RP003082023 RP003082026 RP003089069 RP003095955 RP003097937 RP003118581 RP003137706 RP003139185 RP003149360 RP003153839 RP003163946 RP003168799 RP003171152 RP003184665 RP003194665 RP003206025 RP003207095 RP003217228 RP003222002 RP003234918 RP003238684 RP003239109 RP003246747 RP003255351 RP003267863 RP003283950 RP003285430 RP003290830 RP003297785 RP003300446 RP003302517 RP003342000 RP003367650 RP003367743 RP003380859 RP003380940 RP003390805 RP003394012 RP003417343 RP003421908 RP003444189 RP003448427 RP003460356 RP003460849 RP003462374 RP003467819 RP003469780 RP003470096 RP003484116 RP003493199 RP003502816 RP003532862 RP003533310 RP003535389 RP003540170 RP003549814 RP003552927 RP003579511 RP003595449 RP003617678 RP003652626 RP003658231 RP003661116 RP003668785 RP003675406 RP004011710 RP004029325 RP004075799 RP004092775 RP004122655 RP004135422 RP004143423 RP004147585 RP004152763 RP004167921 RP004169867 RP004190707 RP004196753 RP004196797 RP004204244 RP004214168 RP004215519 RP004216883 RP004219713 RP004231367 RP004233326 RP004237797 RP004238506 RP004239324 RP004243077 RP004245120 RP004246878 RP004259737 RP004265428 RP004290171 RP004324332 RP004336551 RP004375644 RP004391642 RP004424900 RP004448556 RP004476719 RP004520043 RP004522260 RP004524374
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011604 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36390
Antibody Information
	polyclonal (Ito et al., 1999, Ferreira et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Iswi anon-EP1279744.124 (FlyBase, 1996-)
Additional comments	Source for merge of Iswi anon-EP1279744.124 was sequence comparison (date:031211). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. RNAi of Iswi results in increased arborization of ddaD and ddaE neurons, defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Unilateral binding of Iswi protein to a model nucleosome correlates with directional movement of the nucleosome toward the enzyme. (Langst and Becker, 2001) The NURF complex (composed of Caf1, E(bx), Iswi and Nurf-38 proteins) can remodel chromatin and stimulate transcription in vitro irrespective of the acetylation status of histones. (Mizuguchi et al., 2001) The Iswi protein per se, out of the context of a multi subunit complex, is able to remodel nucleosomes, rearrange nucleosomal positions and function as a chromatin assembly factor. (Corona et al., 1999) ACF (ATP-utilizing chromatin assembly and remodeling factor) is a multisubunit factor consisting of 3 polypeptides. These are encoded by Iswi and by Acf1 (this encodes both 170 and 185kD subunits). The p47 polypeptide seen previously in ACF fractions (FBrf0095281) has been found to be identical to Yp2 and appears to have been a contaminant in these earlier ACF fractions. (Ito et al., 1999) The Acf1 and Iswi subunits of ACF (ATP-utilizing chromatin assembly and remodeling factor) function synergistically in the assembly of chromatin. (Ito et al., 1999) Trl- and Iswi-mediated disruption of the chromatin structure within the promoter region of ftz activates transcription on the chromatin template. (Okada and Hirose, 1998) The ATPase activity of Iswi is completely inhibited by each of the four histone tails (His2A, His2B, His3 and His4), results indicate a novel role for the flexible histone tails in chromatin remodeling by Iswi. (Georgel et al., 1997) The interaction between Iswi and nucleosomes is impaired by proteolytic removal of the N-terminal histone tails and by chemical crosslinking of nucleosomal histones. (Georgel et al., 1997) Acf1, a multisubunit factor consisting of polypeptides with molecular masses of 47, 140, 170 and 185kD, has been purified and characterised. The 140kD component is encoded by Iswi. (Ito et al., 1997) Once nucleosome remodelling by the DNA binding factor is accomplished a high level of NURF activity is not continuously required for recruitment of the general transcription machinery and transcription initiation. NURF is able to assist gene activation in a chromatin context: remodel nucleosomes for gene activation in chromatin. (Mizuguchi et al., 1997) NURF, a protein complex of four subunits Caf1, Nurf-38, E(bx) and Iswi, is able to facilitate transcription mediated by a Scer\GAL4 derivative carrying a constitutively activating region from Hsf. (Mizuguchi et al., 1997) A chromatin-accessibility complex (CHRAC), which uses energy to increase the general accessibility of DNA in chromatin, has been identified. CHRAC can also function during chromatin assembly, using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. (Varga-Weisz et al., 1997) The chromatin-accessibility complex (CHRAC) contains 5 subunits, two of which have been identified as the Iswi and Top2 gene products. (Varga-Weisz et al., 1997) Iswi encodes the 140kD subunit of Nucleosome remodeling factor. (Tsukiyama et al., 1995) Nucleosome remodelling factor is composed of at least four polypeptides that act in concert with the Trl transcription factor at the Hsp70 promoter. Nucleosome remodelling factor acts directly on the nucleosome to perturb its structure. (Tsukiyama and Wu, 1995) Identified on the basis of similarity to Scer\snf2. (Elfring et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078995 NM_165930 NM_165931 RefSeq (Proteins) • NP_523719 NP_725203 NP_725204 DDBJ / EMBL / GenBank • AAA19868 AAF58479 AAM11261 AAM68637 AAM68638 AX683150 AY094908 AZ300947 BH840518 BI608595 CZ488977 L27127 Entrez Gene - A searchable database of RefSeq genes. • 36390 UniProtKB/Swiss-Prot • Q24368
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) SANT domain, DNA binding (IPR001005) Helicase, C-terminal (IPR001650) Homeodomain-like (IPR009057) DEAD-like helicase (IPR014001) ATPase, nucleosome remodelling ISWI, HAND domain (IPR015194) SLIDE (IPR015195) SANT, eukarya (IPR017884)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62163 DroID - A comprehensive database of gene and protein interactions. • FBgn0011604 DRSC - Results from RNAi screens. • FBgn0011604 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011604 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8625-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011604 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36390 InParanoid A subset of ortholog calls from InParanoid. • AAEL003968-PA Aedes aegypti (mosquito) AGAP010700-PA Anopheles gambiae (mosquito) XP_396195.2 Apis mellifera (honey bee) XP_001945595.1 Acyrthosiphon pisum (pea aphid) At3g06400.1 Arabidopsis thaliana (wall cress) At5g18620.2 Arabidopsis thaliana (wall cress) 17244 Batrachochytrium dendrobatidis (chytrid fungus) XP_001891999.1 Brugia malayi (roundworm nematode) BGIBMGA000930-PA Bombyx mori (silk worm) ENSBTAP00000004408 Bos taurus (bovine) CAL0001816 Candida albicans (a form of yeast) CN08163 Caenorhabditis brenneri (small nematode) CBP32890 Caenorhabditis briggsae (nematode) CE29792 Caenorhabditis elegans (worm) ENSCAFP00000011181 Canis familiaris (dog) CAGL0I09614g Candida glabrata (haploid yeast) Chro.60441 Cryptosporidium hominis (obligate parasite) ENSCINP00000008494 Ciona intestinalis (sea squirt) JA15722 Caenorhabditis japonica (nematode) CMQ363C Cyanidioschyzon merolae (red alga) cn12203 Cryptococcus neoformans (yeast-like fungus) cgd6_3860 Cryptosporidium parvum (protozoan parasite) CPIJ011038 Culex pipens (mosquito) ENSCPOP00000002050 Cavia porcellus (guinea pig) 135484 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000007729 Ciona savignyi (sedentary tunicate) 18898 Capitella spl (polychaete worm) DDB0231763 Dictyostelium discoideum (amoeba) DEHA2C08294g Debaryomyces Hansenii (yeast) 318579 Daphnia pulex (daphnia) ENSDARP00000023313 Danio rerio (zebra fish) ENSECAP00000004410 Equus caballus (horse) XP_657207 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022775 Gymnopilus aculeatus (mushroom) ENSGALP00000013722 Gallus gallus (chicken) GL50803_8228 Giardia lamblia (flagellated protozoan) 101736 Hypsipyla robusta (cedar shoot borer) ENSP00000283131 Homo sapiens (human) ISCW023393-PA Ixodes scapularis (deer tick) KLLA0F24838g Kluyveromyces lactis (yeast) 182249 Lottia gigantea (owl limpet) LmjF33.1700 Leishmania major (virus) 14315 Monocosta brevicollis (choanoflagellate) ENSMODP00000000470 Monodelphis domestica (gray opossum) ENSMMUP00000001125 Macaca mulatta (rhesus monkey) ENSMUSP00000044361 Mus musculus (house mouse) 226879 Nematostella vectensis (starlet anemone) XP_001601734.1 Nasonia vitripennis (wasp) ENSOANP00000004550 Ornithorynchus anatinus (platypus) LOC_Os01g27040.1 Oryza sativa (asian rice) 34063 Ostreococcus tauri (green alga) PF11_0053 Plasmodium falciparum (protozoal parasite) PHUM004414-PA Pediculus humanus (human body louse) PP02251 Pristionchus pacificus (nematode) 216086 Physcomitrella patens (moss) ENSPPYP00000016857 Pongo pygmaeus (orangutan) 80013 Phytophthora ramorum (sudden oak death pathogen) 119019 Phytophthora sojae (root rot pathogen) 229734 Populus trichocarpa (black cottonwood) ENSPTRP00000028278 Pan troglodytes (chimpanzee) PVX_090890 Plasmodium vivax (protozoal parasite) ENSRNOP00000024568 Rattus norvegicus (norway rat) 5053112 Sorghum bicolor (sorghum) YOR304W Saccharomyces cerevisiae (budding yeast) Smp_008830 Schistosoma mansoni (trematode parasite) XP_001176374.1 Strongylocentrotus purpuratus (purple sea urchin) 60972 Trichoplax adhaerens (metazoa) TA06490 Theileria annulata (apicomplexan parasite) XP_972116.1 Tribolium castaneum (red flour beetle) Tc00.1047053509213.170 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020867 Tetraodon nigroviridis (green spotted pufferfish) TP01_0936 Theileria parva (parasitic protozoan) 12403 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036061 Takifugu rubripes (pufferfish Takifugu) 3698.m00154 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000038157 Xenopus tropicalis (frog) YALI0E02332g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/i-switch.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36390 modMine - Data generated by the modENCODE project. • FBgn0011604 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15374 LH16817 ISCW023393 ISCW010946 FBgn0230228 FBgn0223557 FBgn0208477 FBgn0208475 FBgn0182672 FBgn0176295 JGI_V11_318579 FBgn0081204 FBgn0148685 FBgn0141224 FBgn0130604 FBgn0112517 FBgn0090432 CPIJ011038 BGIBMGA000930 ACYPI006575 ACYPI004047 ACYPI001312 GB14577 AGAP010700 AAEL003968 PB24926 PHUM614620 GLEAN_07199
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	ACF (Dilworth et al., 2004, Alexiadis et al., 2004, An and Roeder, 2003, Alexiadis and Kadonaga, 2002, Ridgway and Almouzni, 2001, Levenstein and Kadonaga, 2002, Nakagawa et al., 2001, Huang and Kadonaga, 2001, Jiang et al., 2000, Farkas et al., 2000, Wu, 2006, Shogren-Knaak et al., 2006) anon-EP1279744.124   CG8625 (Klebes et al., 2005, Gonzalez-Aguero et al., 2005, Schneiderman et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1, Casola et al., 2007) CHRAC (Ridgway and Almouzni, 2001, Ridgway and Almouzni, 2000, Farkas et al., 2000, Glass and Rosenfeld, 2000, Tyler and Kadonaga, 1999, Guschin and Wolffe, 1999, Di Croce et al., 1999, Langst et al., 1999, Kornberg and Lorch, 1999, Reinberg et al., 1998, Jacobson and Pillus, 1999, John and Workman, 1998, Armstrong and Emerson, 1998, Mizuguchi et al., 1997, Kadonaga, 1998, Varga-Weisz et al., 1997) dCHRAC (Boyer et al., 2000, Peterson, 2000) dISWI (Fyodorov and Kadonaga, 2001, Guschin et al., 2000, Dilworth et al., 2000) dNURF (Emerson, 2002, Fry and Peterson, 2001, Boyer et al., 2000, Peterson, 2000) ISW (Cryderman et al., 1999) ISWI (Henikoff et al., 2009, Varga-Weisz, 2006, Grune et al., 2003, Xi and Xie, 2005, de la Cruz et al., 2005, Eberharter et al., 2004, Eberharter and Becker, 2004, Flaus and Owen-Hughes, 2004, Aalfs and Kingston, 2000, Fyodorov et al., 2004, Hochheimer and Tjian, 2003, Bonaldi et al., 2002, Armstrong et al., 2002, Eberharter et al., 2001, Corona et al., 2001, Mello and Almouzni, 2001, Zaret and Wolffe, 2001, Papoulas et al., 2001, Farkas et al., 2000, Corona et al., 2000, Brehm et al., 2000, Aasland, 2000, Tyler and Kadonaga, 1999, Collins et al., 1999, Elfring, 1994.7.19, Kornberg and Lorch, 1999, Cryderman et al., 1999, LeRoy et al., 1998, Alexiadis et al., 1998, Okada and Hirose, 1998, Martinez-Balbas et al., 1998, Varga-Weisz et al., 1997, Carlson and Laurent, 1994, Straub and Becker, 2007, Wu, 2006, Jacquier et al., 2007, Kruger, 2005, Kruger, 2005, Nystul and Spradling, 2006, Parrish et al., 2006, Furuhashi et al., 2006, Onorati et al., 2011, Prestel et al., 2010, Arancio et al., 2010, Konev et al., 2007, Georges et al., 2002, Fyodorov and Kadonaga, 2002, Dilworth et al., 2000, Taylor-Harding et al., 2004, Chalkley et al., 2008, Srinivasan et al., 2008, Petesch and Lis, 2008, Fanti et al., 2008, Sala et al., 2011, Corona et al., 2002, Siriaco et al., 2009, Yokoyama et al., 2009, Sala et al., 2008, Moshkin et al., 2009, Ferreira et al., 2007, Hanai et al., 2008, Kopytova et al., 2006, Burgio et al., 2008, Li et al., 2010, Emelyanov et al., 2010, Reddy et al., 2010, Di Stefano et al., 2011, van Uden et al., 2011, Lusser et al., 2005, Santoso and Kadonaga, 2006, Strohner et al., 2005) iswi (Evans et al., 2003, Badenhorst et al., 2002, Xi and Xie, 2005, Kruger, 2005, D and Emerson, 2006, Liu et al., 2008, Schneiderman et al., 2009) Iswi (Schuettengruber, 2006, Cayirlioglu et al., 2003, Bai et al., 2007, Gan et al., 2010, Matsumoto et al., 2007, Gabut et al., 2007, Corona et al., 2007, Carré et al., 2008, Keuling et al., 2007, Zhou et al., 2008, Wasbrough et al., 2010, Kugler and Nagel, 2010) NURF (Varga-Weisz, 2006, Baumann et al., 2003, Shen et al., 2003, Wu, 2001, Ridgway and Almouzni, 2001, Mizuguchi et al., 2001, Jones and Kadonaga, 2000, Farkas et al., 2000, Glass and Rosenfeld, 2000, Tyler and Kadonaga, 1999, Di Croce et al., 1999, Kornberg and Lorch, 1999, Wu et al., 1998, Reinberg et al., 1998, Jacobson and Pillus, 1999, John and Workman, 1998, Gregory and Horz, 1998, Armstrong and Emerson, 1998, Luger and Richmond, 1998, Mizuguchi et al., 1997, Kadonaga, 1998, Mizzen and Allis, 1998, Cairns, 1998, Gregory and Horz, 1998, Tsukiyama and Wu, 1997, Georgel et al., 1997, Burns and Peterson, 1997, Peterson, 1996, Kingston et al., 1996, Wysocka et al., 2006) NURF-140 (Hamiche et al., 1999) Nurf-140   p140 (Hochheimer et al., 2002) p140/ISWI (Hochheimer et al., 2002) SWI (Guschin and Wolffe, 1999)
Name Synonym	Imitation SW (Gabut et al., 2007) imitation-SWI (Elfring, 1994.7.19) Imitation SWI (Xi and Xie, 2005) imitation SWI (Nystul and Spradling, 2006) ISWI ATPase (Badenhorst et al., 2000) Nucleosome remodeling factor (Kingston et al., 1996) Nucleosome remodeling factor - 140kD
Secondary FlyBase IDs
	FBgn0010436 FBgn0066055
References ( 212 )
Generate a list of	All references relating to this gene ( 212 )
List References by type	Research paper  ( 121 ) Supplementary material  ( 7 ) Review  ( 58 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 13 )
	Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] Onorati et al., 2011, PLoS Genet. 7(5): e1002096 The ISWI Chromatin Remodeler Organizes the hsrω ncRNA–Containing Omega Speckle Nuclear Compartments. [FBrf0213856] Sala et al., 2011, EMBO J. 30(9): 1766--1777 Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. [FBrf0213629] van Uden et al., 2011, PLoS Genet. 7(1): e1001285 Evolutionary Conserved Regulation of HIF-1β by NF-κB. [FBrf0212948] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Cherry and Matunis, 2010, Cell Stem Cell 6(6): 557--567 Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF. [FBrf0211111] Emelyanov et al., 2010, J. Biol. Chem. 285(20): 15027--15037 Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo. [FBrf0210725] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Kugler and Nagel, 2010, Mol. Biol. Cell 21(19): 3443--3448 A novel Pzg-NURF complex regulates Notch target gene activity. [FBrf0211977] Li et al., 2010, Mol. Cell. Biol. 30(4): 1067--1076 Modulation of Chromatin Boundary Activities by Nucleosome-Remodeling Activities in Drosophila melanogaster. [FBrf0209771] Prestel et al., 2010, Mol. Cell 38(6): 815--826 The Activation Potential of MOF Is Constrained for Dosage Compensation. [FBrf0211211] Reddy et al., 2010, Mol. Cell. Biol. 30(21): 5234--5244 Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD. [FBrf0212010] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...