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Gene Dmel\lark

General Information
Symbol	Dmel\lark	Species	D. melanogaster
Name	lark	Annotation symbol	CG8597
Feature type	protein_coding_gene	FlyBase ID	FBgn0011640
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	65F5-65F5	Sequence location	3L:7,332,366..7,334,996 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lark is referred to in FlyBase by the symbol Dmel\lark (CG8597, FBgn0011640). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: protein localization; actin cytoskeleton organization; circadian rhythm; mitosis; negative regulation of eclosion; oogenesis; embryo development; eclosion rhythm; cytoplasmic transport, nurse cell to oocyte. 29 alleles are reported. The phenotypes of these alleles are annotated with: adult cuticle; scutellar bristle; wing; posterior scutellar bristle. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain; Zinc finger, CCHC retroviral-type; Zinc finger, CCHC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628340_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of lark. Gene sequence location is 3L:7332366..7334996.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA11362 BKN27711 BKN45939
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65F5-65F5   Limits computationally determined from genome sequence between P{lacW}Cdc27L7123 and P{EP}larkEP3259&P{lacW}l(3)j1D5j1D5
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65E-65F     (Newby, 1996.5.29)
Experimentally Determined Recombination Data
Location	3- (Newby, 1996.5.29) 3-17.8 (Newby and Jackson, 1993)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lark for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lark-RA FBtr0076841  NM_079233   1832   352 lark-RB FBtr0076842  NM_168202   1738   352 lark-RC FBtr0076843  NM_168203   1779   352 lark-RD FBtr0076844  NM_168204   1761   352 lark-RE FBtr0076845  NM_168205   2082   352
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lark-PA   FBpp0076552   39.9   352   9.30     NP_523957   AAF50578 lark-PB   FBpp0076553   39.9   352   9.30     NP_729237   AAN12053 lark-PC   FBpp0076554   39.9   352   9.30     NP_729238   AAN12054 lark-PD   FBpp0076555   39.9   352   9.30     NP_729239   AAN12055 lark-PE   FBpp0076556   39.9   352   9.30     NP_729240   AAN12056
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, CCHC-type (IPR001878) Nucleotide-binding, alpha-beta plait (IPR012677) Zinc finger, CCHC retroviral-type (IPR013084)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201477   AA202298   AA202409   AA203087   AA203099   AA392131   AA392351   AA438332   AA439658   AA440971   AA538979   AA568043   AA802108   AA803179   AE014296 AAF50578   AE014296 AAN12053   AE014296 AAN12054   AE014296 AAN12055   AE014296 AAN12056   AI109223   AI258957   AI259916   AI260565   AI296199   AI388160   AI455040   AI456304   AI514057   AI520594   AI534211   AI534723   AI946191   AQ025307   AW943534   AY061458 AAL29006   BF486000   BF488247   BF490964   BF494940   BF501713   BF503000   BG634255   BG635259   BG640196   BI212860   BI229625   BI232697   BI235069   BI235434   BI237618   BI362740   BI371122   BI371512   BI484091   BI576104   BI591985   BI609974   BI615566   BI622034   BI627080   BP546093   BP551880   BP551881   BQ103049   BQ103217   BZ748759   CK657588   CK661696   CO156594   CO188961   CO263320   CO266244   CO267352   CO276220   CO279410   CO289743   CO295880   CO302767   CO307918   CO333278   CO335397   CO335838   CO341439   CZ466798   CZ474145   DN154027   EC058836   EC060722   EC061160   EC061945   EC073017   EC084598   EC194397   EC194980   EC197476   EC197556   EC211822   EC221896   EC221910   EC228303   EC241216   EC247590   EC247658   EC254739   EC262140   EC262272   EC264057   ES696491   ES696495   EV584356   EV584531   EV584782   EV586823   EV594650   EV595317   EV595608   U59476 AAB07067
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q94901
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 6   organism | ubiquitous & uniform   (McNeil et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism   (McNeil et al., 1999) Comment:reference stages 0-2 hr AEL embryonic stage 17   organism   (McNeil et al., 1999) Comment:reference stages 16-18 hr AEL pupal stage   organism   (McNeil et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   embryonic cortex   (McNeil et al., 1999) embryonic stage 4 -- 11   organism | ubiquitous   (McNeil et al., 1999) embryonic stage 5 -- 11   cell   (McNeil et al., 1999) adult stage | female & oogenesis   egg chamber | ubiquitous   (McNeil et al., 1999) follicle cell   (McNeil et al., 1999) oogenesis & adult stage | female   nurse cell   (McNeil et al., 1999) oocyte   (McNeil et al., 1999) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 8   organism   (McNeil et al., 1999) Comment:0-3.5 hr AEL unfertilized egg stage   unfertilized egg   (McNeil et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011640    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011640 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011640 expression level Developmental Stage   Expression Level embryo 00-02hr    11341 embryo 02-04hr    17165 embryo 04-06hr    14787 embryo 06-08hr    14962 embryo 08-10hr    11598 embryo 10-12hr    10929 embryo 12-14hr    6583 embryo 14-16hr    6935 embryo 16-18hr    4052 embryo 18-20hr    3429 embryo 20-22hr    2273 embryo 22-24hr    1885 larva L1    3072 larva L2    3740 larva L3 12hr old    2768 larva L3 puffstage 1-2    2713 larva L3 puffstage 3-6    4306 larva L3 puffstage 7-9    4713 white prepupae new    4521 white prepupae 12hr    5179 white prepupae 24hr    6768 pupae 2d postWPP    4376 pupae 3d postWPP    2107 pupae 4d postWPP    2294 adult male 01day    1867 adult male 05day    2444 adult male 30day    2559 adult female 01day    4984 adult female 05day    5894 adult female 30day    6350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11341) embryo 02-04hr  (17165) embryo 04-06hr  (14787) embryo 06-08hr  (14962) embryo 08-10hr  (11598) embryo 10-12hr  (10929) embryo 12-14hr  (6583) embryo 14-16hr  (6935) embryo 16-18hr  (4052) embryo 18-20hr  (3429) embryo 20-22hr  (2273) embryo 22-24hr  (1885) larva L1  (3072) larva L2  (3740) larva L3 12hr old  (2768) larva L3 puffstage 1-2  (2713) larva L3 puffstage 3-6  (4306) larva L3 puffstage 7-9  (4713) white prepupae new  (4521) white prepupae 12hr  (5179) white prepupae 24hr  (6768) pupae 2d postWPP  (4376) pupae 3d postWPP  (2107) pupae 4d postWPP  (2294) adult male 01day  (1867) adult male 05day  (2444) adult male 30day  (2559) adult female 01day  (4984) adult female 05day  (5894) adult female 30day  (6350) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11341) embryo 02-04hr  (17165) embryo 04-06hr  (14787) embryo 06-08hr  (14962) embryo 08-10hr  (11598) embryo 10-12hr  (10929) embryo 12-14hr  (6583) embryo 14-16hr  (6935) embryo 16-18hr  (4052) embryo 18-20hr  (3429) embryo 20-22hr  (2273) embryo 22-24hr  (1885) larva L1  (3072) larva L2  (3740) larva L3 12hr old  (2768) larva L3 puffstage 1-2  (2713) larva L3 puffstage 3-6  (4306) larva L3 puffstage 7-9  (4713) white prepupae new  (4521) white prepupae 12hr  (5179) white prepupae 24hr  (6768) pupae 2d postWPP  (4376) pupae 3d postWPP  (2107) pupae 4d postWPP  (2294) adult male 01day  (1867) adult male 05day  (2444) adult male 30day  (2559) adult female 01day  (4984) adult female 05day  (5894) adult female 30day  (6350) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11341) embryo 02-04hr  (17165) embryo 04-06hr  (14787) embryo 06-08hr  (14962) embryo 08-10hr  (11598) embryo 10-12hr  (10929) embryo 12-14hr    6583 embryo 14-16hr    6935 embryo 16-18hr    4052 embryo 18-20hr    3429 embryo 20-22hr    2273 embryo 22-24hr    1885 larva L1    3072 larva L2    3740 larva L3 12hr old    2768 larva L3 puffstage 1-2    2713 larva L3 puffstage 3-6    4306 larva L3 puffstage 7-9    4713 white prepupae new    4521 white prepupae 12hr    5179 white prepupae 24hr    6768 pupae 2d postWPP    4376 pupae 3d postWPP    2107 pupae 4d postWPP    2294 adult male 01day    1867 adult male 05day    2444 adult male 30day    2559 adult female 01day    4984 adult female 05day    5894 adult female 30day    6350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11341 embryo 02-04hr    17165 embryo 04-06hr    14787 embryo 06-08hr    14962 embryo 08-10hr    11598 embryo 10-12hr    10929 embryo 12-14hr    6583 embryo 14-16hr    6935 embryo 16-18hr    4052 embryo 18-20hr    3429 embryo 20-22hr    2273 embryo 22-24hr    1885 larva L1    3072 larva L2    3740 larva L3 12hr old    2768 larva L3 puffstage 1-2    2713 larva L3 puffstage 3-6    4306 larva L3 puffstage 7-9    4713 white prepupae new    4521 white prepupae 12hr    5179 white prepupae 24hr    6768 pupae 2d postWPP    4376 pupae 3d postWPP    2107 pupae 4d postWPP    2294 adult male 01day    1867 adult male 05day    2444 adult male 30day    2559 adult female 01day    4984 adult female 05day    5894 adult female 30day    6350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011640 expression level Developmental Stage   Expression Level embryo 00-02hr    11341 embryo 02-04hr    17165 embryo 04-06hr    14787 embryo 06-08hr    14962 embryo 08-10hr    11598 embryo 10-12hr    10929 embryo 12-14hr    6583 embryo 14-16hr    6935 embryo 16-18hr    4052 embryo 18-20hr    3429 embryo 20-22hr    2273 embryo 22-24hr    1885 larva L1    3072 larva L2    3740 larva L3 12hr old    2768 larva L3 puffstage 1-2    2713 larva L3 puffstage 3-6    4306 larva L3 puffstage 7-9    4713 white prepupae new    4521 white prepupae 12hr    5179 white prepupae 24hr    6768 pupae 2d postWPP    4376 pupae 3d postWPP    2107 pupae 4d postWPP    2294 adult male 01day    1867 adult male 05day    2444 adult male 30day    2559 adult female 01day    4984 adult female 05day    5894 adult female 30day    6350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11341) embryo 02-04hr  (17165) embryo 04-06hr  (14787) embryo 06-08hr  (14962) embryo 08-10hr  (11598) embryo 10-12hr  (10929) embryo 12-14hr  (6583) embryo 14-16hr  (6935) embryo 16-18hr  (4052) embryo 18-20hr  (3429) embryo 20-22hr  (2273) embryo 22-24hr  (1885) larva L1  (3072) larva L2  (3740) larva L3 12hr old  (2768) larva L3 puffstage 1-2  (2713) larva L3 puffstage 3-6  (4306) larva L3 puffstage 7-9  (4713) white prepupae new  (4521) white prepupae 12hr  (5179) white prepupae 24hr  (6768) pupae 2d postWPP  (4376) pupae 3d postWPP  (2107) pupae 4d postWPP  (2294) adult male 01day  (1867) adult male 05day  (2444) adult male 30day  (2559) adult female 01day  (4984) adult female 05day  (5894) adult female 30day  (6350) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11341) embryo 02-04hr  (17165) embryo 04-06hr  (14787) embryo 06-08hr  (14962) embryo 08-10hr  (11598) embryo 10-12hr  (10929) embryo 12-14hr  (6583) embryo 14-16hr  (6935) embryo 16-18hr  (4052) embryo 18-20hr  (3429) embryo 20-22hr  2273 embryo 22-24hr  1885 larva L1  (3072) larva L2  (3740) larva L3 12hr old  (2768) larva L3 puffstage 1-2  (2713) larva L3 puffstage 3-6  (4306) larva L3 puffstage 7-9  (4713) white prepupae new  (4521) white prepupae 12hr  (5179) white prepupae 24hr  (6768) pupae 2d postWPP  (4376) pupae 3d postWPP  2107 pupae 4d postWPP  2294 adult male 01day  1867 adult male 05day  2444 adult male 30day  (2559) adult female 01day  (4984) adult female 05day  (5894) adult female 30day  (6350) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11341 embryo 02-04hr  17165 embryo 04-06hr  14787 embryo 06-08hr  14962 embryo 08-10hr  11598 embryo 10-12hr  10929 embryo 12-14hr    6583 embryo 14-16hr    6935 embryo 16-18hr    4052 embryo 18-20hr    3429 embryo 20-22hr    2273 embryo 22-24hr    1885 larva L1    3072 larva L2    3740 larva L3 12hr old    2768 larva L3 puffstage 1-2    2713 larva L3 puffstage 3-6    4306 larva L3 puffstage 7-9    4713 white prepupae new    4521 white prepupae 12hr    5179 white prepupae 24hr    6768 pupae 2d postWPP    4376 pupae 3d postWPP    2107 pupae 4d postWPP    2294 adult male 01day    1867 adult male 05day    2444 adult male 30day    2559 adult female 01day    4984 adult female 05day    5894 adult female 30day    6350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11341 embryo 02-04hr    17165 embryo 04-06hr    14787 embryo 06-08hr    14962 embryo 08-10hr    11598 embryo 10-12hr    10929 embryo 12-14hr    6583 embryo 14-16hr    6935 embryo 16-18hr    4052 embryo 18-20hr    3429 embryo 20-22hr    2273 embryo 22-24hr    1885 larva L1    3072 larva L2    3740 larva L3 12hr old    2768 larva L3 puffstage 1-2    2713 larva L3 puffstage 3-6    4306 larva L3 puffstage 7-9    4713 white prepupae new    4521 white prepupae 12hr    5179 white prepupae 24hr    6768 pupae 2d postWPP    4376 pupae 3d postWPP    2107 pupae 4d postWPP    2294 adult male 01day    1867 adult male 05day    2444 adult male 30day    2559 adult female 01day    4984 adult female 05day    5894 adult female 30day    6350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011640    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011640 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011640 expression level Tissue   Expression Level Larval Central Nervous System    1026.4 Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea    517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain    624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary    725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1026.4) Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea  517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain  (624.1) Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary  (725.5) Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1026.4 Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea    517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain    624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary    725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1026.4 Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea    517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain    624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary    725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011640 expression level Tissue   Expression Level Larval Central Nervous System    1026.4 Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea    517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain    624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary    725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1026.4) Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea  517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain  624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary  725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1026.4 Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea    517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain    624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary    725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1026.4 Larval Midgut    343.1 Larval Hindgut    488.3 Larval Malpighian Tubules    309.3 Larval Fat Body    495.4 Larval Salivary Gland    499.8 Larval Trachea    517.325 Larval Carcass    454.125 Adult Head    285.2 Adult Eye    486.525 Adult Brain    624.1 Adult Thoracic-Abdominal Ganglion    418.5 Adult Crop    396.3 Adult Midgut    313.5 Adult Hindgut    357.5 Adult Malpighian Tubules    316.3 Adult Fat Body    277.6 Adult Salivary Gland    493 Adult Heart    297.725 Adult VirginFemale Spermatheca    238.9 Adult InseminatedFemale Spermatheca    252.5 Adult Ovary    725.5 Adult Testis    195 Adult Male Accessory Gland    473.7 Adult Carcass    306 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    285.2   NA  Eye    486.525   NA  Brain    624.1   1026.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    418.5   NA  Crop    396.3   343.1  Midgut    313.5   488.3  Hindgut    357.5   309.3  Malpighian Tubules    316.3   495.4  Fat Body    277.6   499.8  Salivary Gland    493   NA  Heart    297.725   517.325  Trachea    NA   NA  VirginFemale Spermatheca    238.9   NA  InseminatedFemale Spermatheca    252.5   NA  Ovary    725.5   NA  Testis    195   NA  Male Accessory Gland    473.7   454.125  Carcass    306 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011640 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8597-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive lark1 lethal | pharate adult stage, with Scer\GAL4elav-C155 larkScer\UAS.T:Ivir\HA1 lethal | pupal stage, with Scer\GAL4Act5C.PHb larkScer\UAS.T:Ivir\HA1 lethal | recessive lark1 larkR1 larkR2 larkR3 larkR4 larkR5 larkR6 semi-lethal | pharate adult stage, with Scer\GAL4386Y larkScer\UAS.T:Ivir\HA1 semi-lethal | pharate adult stage, with Scer\GAL4dimm-929 larkScer\UAS.T:Ivir\HA1 viable, with Scer\GAL4Ccap.PP larkScer\UAS.T:Ivir\HA1 viable, with Scer\GAL4P2.4.Pdf larkScer\UAS.T:Ivir\HA1 viable, with Scer\GAL4ple.PF larkScer\UAS.T:Ivir\HA1 viable, with Scer\GAL4tim.PE larkScer\UAS.T:Ivir\HA1 Sterility Allele female fertile, with lark1 larkcMa.T:Ivir\HA1 larkRRM1.RNP2.T:Ivir\HA1 female fertile, with larkcMa.T:Ivir\HA1 lark1 female fertile, with larkRRM1.RNP2.T:Ivir\HA1 lark1 female sterile, with lark1 larkRRM1+RTZF.T:Ivir\HA1 larkRRM2.RNP2.T:Ivir\HA1 larkRRM2+RTZF.T:Ivir\HA1 female sterile, with larkRRM1+RTZF.T:Ivir\HA1 lark1 female sterile, with larkRRM2.RNP2.T:Ivir\HA1 lark1 female sterile, with larkRRM2+RTZF.T:Ivir\HA1 lark1 male fertile, with lark1 larkcMa.T:Ivir\HA1 larkRRM1.RNP2.T:Ivir\HA1 larkRRM1+RTZF.T:Ivir\HA1 larkRRM2.RNP2.T:Ivir\HA1 larkRRM2+RTZF.T:Ivir\HA1 male fertile, with larkcMa.T:Ivir\HA1 lark1 male fertile, with larkRRM1.RNP2.T:Ivir\HA1 lark1 male fertile, with larkRRM1+RTZF.T:Ivir\HA1 lark1 male fertile, with larkRRM2.RNP2.T:Ivir\HA1 lark1 male fertile, with larkRRM2+RTZF.T:Ivir\HA1 lark1 Other Phenotypes Allele behavior defective | dominant lark1 eclosion rhythm defective, with Scer\GAL4Ccap.PP larkScer\UAS.T:Ivir\HA1 eclosion rhythm defective, with Scer\GAL4Eh.2.4 larkScer\UAS.T:Ivir\HA1 eclosion rhythm defective, with Scer\GAL4tim.PE larkScer\UAS.T:Ivir\HA1 flight defective, with lark1 larkRRM2.RNP2.T:Ivir\HA1 flight defective, with larkRRM2.RNP2.T:Ivir\HA1 lark1 flightless, with lark1 larkRRM1+RTZF.T:Ivir\HA1 larkRRM2+RTZF.T:Ivir\HA1 larkZF.T:Ivir\HA1 flightless, with larkRRM1+RTZF.T:Ivir\HA1 lark1 flightless, with larkRRM2+RTZF.T:Ivir\HA1 lark1 flightless, with larkZF.T:Ivir\HA1 lark1 locomotor rhythm defective, with Scer\GAL4P2.4.Pdf larkScer\UAS.T:Ivir\HA1 locomotor rhythm defective, with Scer\GAL4tim.PE larkScer\UAS.T:Ivir\HA1 visible, with lark1 larkRRM2.RNP2.T:Ivir\HA1 larkRRM2+RTZF.T:Ivir\HA1 larkZF.T:Ivir\HA1 visible, with larkRRM2.RNP2.T:Ivir\HA1 lark1 visible, with larkRRM2+RTZF.T:Ivir\HA1 lark1 visible, with larkZF.T:Ivir\HA1 lark1 visible, with Scer\GAL4386Y larkScer\UAS.T:Ivir\HA1 visible, with Scer\GAL4bbg-C96 larkd04807 visible, with Scer\GAL4Ccap.PP larkScer\UAS.T:Ivir\HA1 visible, with Scer\GAL4Eh.2.4 larkScer\UAS.T:Ivir\HA1 wild-type lark+mMa larkcMa.T:Ivir\HA1 larkRRM1.RNP2.T:Ivir\HA1 Phenotype manifest in Allele adult cuticle, with Scer\GAL4386Y larkScer\UAS.T:Ivir\HA1 adult cuticle, with Scer\GAL4Ccap.PP larkScer\UAS.T:Ivir\HA1 adult cuticle, with Scer\GAL4Eh.2.4 larkScer\UAS.T:Ivir\HA1 adult cuticle, with Scer\GAL4elav-C155 larkScer\UAS.T:Ivir\HA1 embryo | germline clone lark1 posterior scutellar bristle, with lark1 larkZF.T:Ivir\HA1 posterior scutellar bristle, with larkZF.T:Ivir\HA1 lark1 scutellar bristle, with lark1 larkRRM2+RTZF.T:Ivir\HA1 larkRRM2.RNP2.T:Ivir\HA1 larkZF.T:Ivir\HA1 scutellar bristle, with larkRRM2.RNP2.T:Ivir\HA1 lark1 scutellar bristle, with larkRRM2+RTZF.T:Ivir\HA1 lark1 scutellar bristle, with larkZF.T:Ivir\HA1 lark1 scutellar bristle | ectopic, with lark1 larkZF.T:Ivir\HA1 scutellar bristle | ectopic, with larkZF.T:Ivir\HA1 lark1 wing, with lark1 larkRRM2+RTZF.T:Ivir\HA1 larkRRM2.RNP2.T:Ivir\HA1 larkZF.T:Ivir\HA1 wing, with larkRRM2.RNP2.T:Ivir\HA1 lark1 wing, with larkRRM2+RTZF.T:Ivir\HA1 lark1 wing, with larkZF.T:Ivir\HA1 lark1 wing, with Scer\GAL4386Y larkScer\UAS.T:Ivir\HA1 wing, with Scer\GAL4bbg-C96 larkd04807 wing, with Scer\GAL4Ccap.PP larkScer\UAS.T:Ivir\HA1 wing, with Scer\GAL4Eh.2.4 larkScer\UAS.T:Ivir\HA1 wing, with Scer\GAL4elav-C155 larkScer\UAS.T:Ivir\HA1
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of lark Class Mutagen Stocks Known lesion larkc01004 piggyBac transposase 1 -- larkd04807 P-element activity 1 -- larkDG23107 P-element activity 1 -- larkEY00297 P-element activity 1 -- larkEY23084 P-element activity 1 -- lark1 Delta2-3 P-element activity 0 Yes lark5-HA-2401 0 -- larka 0 -- larkEP3259 P-element activity 0 -- larkR1 Delta2-3 0 Yes larkR2 Delta2-3 0 Yes larkR3 Delta2-3 0 Yes larkR4 Delta2-3 0 Yes larkR5 Delta2-3 0 Yes larkR6 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lark Class Mutagen Stocks Known lesion larkJF02783 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes larkScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 1 Yes lark+mMa in vitro construct 0 Yes larkcMa.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes larkF10A.F89A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes larkGD1310 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes larkKK107711 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes larkRRM1+2.RNP2.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes larkRRM1+RTZF.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes larkRRM1.RNP2.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes larkRRM2+RTZF.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes larkRRM2.RNP2.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes larkZF.T:Ivir\HA1 in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes larkΔC.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;Y)A76 (Newby and Jackson, 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1310} NA P{KK107711} NA P{TRiP.JF02783} NA P{UAS-lark-3HA} NA P{UAS-lark.F10A.F89A} NA characterization construct P{lark.RRM1.RNP2} NA P{lark.RRM1+2.RNP2} NA P{lark.RRM1+RTZF} NA P{lark.RRM2.RNP2} NA P{lark.RRM2+RTZF} NA P{lark.ZF} NA P{lark.ΔC} NA P{lark+.HA} NA P{lark+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}larkEP3259 NA P{EPgy2}larkEY00297 NA P{EPgy2}larkEY23084 NA P{XP}larkd04807 NA miscellaneous insertions P{RS5}lark5-HA-2401 NA P{wHy}larkDG23107 NA PBac{PB}larkc01004 NA insertion of enhancer trap P{lacW}lark1 No
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (assigned by UniProtKB) (McNeil et al., 2004) circadian rhythm inferred from mutant phenotype (Newby and Jackson, 1993) cytoplasmic transport, nurse cell to oocyte inferred from mutant phenotype (assigned by UniProtKB) (McNeil et al., 2004) eclosion rhythm inferred from mutant phenotype (Newby and Jackson, 1993) inferred from mutant phenotype (assigned by UniProtKB) (Newby and Jackson, 1996) embryo development inferred from mutant phenotype (Newby and Jackson, 1993) mitosis inferred from mutant phenotype (Ducat et al., 2008) negative regulation of eclosion inferred from mutant phenotype (Newby and Jackson, 1993) inferred from mutant phenotype (assigned by UniProtKB) (Newby and Jackson, 1996) oogenesis inferred from mutant phenotype (assigned by UniProtKB) (McNeil et al., 2004) protein localization inferred from mutant phenotype (assigned by UniProtKB) (McNeil et al., 2004)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytoplasm inferred from direct assay (assigned by UniProtKB) (McNeil et al., 1998) nucleus inferred from direct assay (assigned by UniProtKB) (McNeil et al., 1998, McNeil et al., 2001) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Newby and Jackson, 1995, Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504, InterPro:IPR001878, InterPro:IPR013084 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) RNA binding non-traceable author statement (assigned by UniProtKB) (McNeil et al., 2004) zinc ion binding inferred from electronic annotation with InterPro:IPR001878, InterPro:IPR013084 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
circadian rhythm non-traceable author statement (Sokolowski, 2001) eclosion traceable author statement (Hendricks, 2003) eclosion rhythm non-traceable author statement (Sokolowski, 2001) traceable author statement (Panda et al., 2002, Stanewsky, 2003) NOT locomotion traceable author statement (Hendricks, 2003) locomotor rhythm traceable author statement (Panda et al., 2002) nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lark allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64251 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011640 DroID - A comprehensive database of gene and protein interactions. • FBgn0011640 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38811
Orthologs
Genome-wide drosophilid orthologs	Dpse\GA21193
Curated drosophilid orthologs	Dpse\GA21193
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013982-PA Aedes aegypti (mosquito) XP_623841.2 Apis mellifera (honey bee) XP_001943947.1 Acyrthosiphon pisum (pea aphid) 32353 Batrachochytrium dendrobatidis (chytrid fungus) 83339 Branchiostoma floridae (lancelet) 83361 Branchiostoma floridae (lancelet) BGIBMGA007410-PA Bombyx mori (silk worm) ENSBTAP00000000541 Bos taurus (bovine) ENSBTAP00000007153 Bos taurus (bovine) CBP33695 Caenorhabditis briggsae (nematode) CE15447 Caenorhabditis elegans (worm) ENSCAFP00000018230 Canis familiaris (dog) CPIJ009028 Culex pipens (mosquito) ENSCPOP00000012327 Cavia porcellus (guinea pig) 224043 Capitella spl (polychaete worm) ENSDARP00000071862 Danio rerio (zebra fish) ENSECAP00000020394 Equus caballus (horse) ENSGACP00000001061 Gymnopilus aculeatus (mushroom) ENSGALP00000029322 Gallus gallus (chicken) ENSP00000310471 Homo sapiens (human) ISCW015020-PA Ixodes scapularis (deer tick) KLLA0F18216g Kluyveromyces lactis (yeast) ENSMODP00000010014 Monodelphis domestica (gray opossum) ENSMMUP00000013865 Macaca mulatta (rhesus monkey) ENSMUSP00000038256 Mus musculus (house mouse) ENSOANP00000004983 Ornithorynchus anatinus (platypus) ENSOANP00000017481 Ornithorynchus anatinus (platypus) ENSORLP00000015616 Oryzias latipes (japanese killifish) PHUM005048-PA Pediculus humanus (human body louse) ENSPPYP00000003487 Pongo pygmaeus (orangutan) 244286 Populus trichocarpa (black cottonwood) ENSPTRP00000006780 Pan troglodytes (chimpanzee) ENSRNOP00000026605 Rattus norvegicus (norway rat) Smp_079290.1 Schistosoma mansoni (trematode parasite) XP_001175941.1 Strongylocentrotus purpuratus (purple sea urchin) XP_970745.1 Tribolium castaneum (red flour beetle) Tc00.1047053509317.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511621.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000000403 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033958 Takifugu rubripes (pufferfish Takifugu) 82538.m00091 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008271 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23065 LH22860 FBgn0081181 CPIJ009028 BGIBMGA007410 ACYPI010087 ACYPI008424 ACYPI003756 GB13251 AAEL013982 PB23863 PHUM127250 GLEAN_06476
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	7125 w1118; P{UAS-lark-3HA}23A 27703 y1 v1; P{TRiP.JF02783}attP2 15287 y1 w67c23; P{EPgy2}larkEY00297 ecoEY00297 20624 y1 w67c23; P{wHy}larkDG23107/TM3, Sb1 Ser1 22604 y1 w67c23; P{EPgy2}larkEY23084/TM3, Sb1 Ser1
Harvard	- P{XP}larkd04807 - PBac{PB}larkc01004
Genomic Clones ( 2 )
	BACR09E21 BACR11B04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 103 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD40792
Other clones	DPiM_LD40792
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03727 AT17196 AT18884 AT20121 AT23471 AT27606 AT30411 AT31779 GH08352 GH18968 GH27111 GM03865 GM10352 HL01213 LD02452 LD02580 LD03587 LD03603 LD04379 LD06268 LD11104 LD11222 LD12284 LD12790 LD14282 LD18663 LD36208 LP02267 LP03440 LP04478 LP10035 LP21351 LP24006 RE18123 RE27445 RE28811 RE30872 RE31276 RE33869 RE47389 RE57947 RE58423 RE67124 RH09564 RH14834 RH32606 RH45244 RH53844 RH68278 SD06794 SD07724 SD11161
Other clones	17886 20958 35059 35243 35363 37656 42111 61388 79882 81134 214403.68 281434 527874 533837 542785 bs21h11 CK01.3D.C8 CK01.28D.G3 CK01.52C.E8 CK01.92A.C2 CK01.142D.B4 CK01.147A.F11 Dmel_dig_004036_0625_2450 Dmel_dig_006434_0623_1932 Dmel_dig_016171_0674_1244 Dmel_neb_010901_0590_0408 Dmel_neb_012967_0662_2286 Dmel_neb_013532_0113_0396 Dmel_neb_014116_0613_1834 EK042552 EK071941 EK088217 EK120024 EK134247 EK145540 EK149534 EK155216 EK184849 EK211942 EK256203 EK306359 EN08352 EN10245 EN11327 EP12442 FGH102G05 FGM215D05 UUGC0445 UUGC0617
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011640 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38811
Antibody Information
	polyclonal (Newby and Jackson, 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The lark RNA-binding protein oscillates in abundance during the circadian cycle. (McNeil et al., 1998) Results from mRNA expression pattern studies and gene dosage experiments suggest lark is required for the posttranscriptional repression of genes encoding other elements of the clock output pathway. (Newby and Jackson, 1996) The lark gene encodes an essential embryonic product which is also required later in development for the daily timing of adult eclosion. The lark protein is a repressor, a member of the RNP (RMM) class of RNA-binding proteins, which mediates inhibition of eclosion until an appropriate time of day. (Newby and Jackson, 1995) Mutants of lark alter the timing of eclosion but do not perturb circadian period or the expression of the activity rhythm. lark gene product has an essential function and is one element of the output pathway mediating the pacemaker control of eclosion. (Newby and Jackson, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079233 NM_168202 NM_168203 NM_168204 NM_168205 RefSeq (Proteins) • NP_523957 NP_729237 NP_729238 NP_729239 NP_729240 DDBJ / EMBL / GenBank • AAB07067 AAF50578 AAF50578.1 AAL29006 AAN12053 AAN12053.1 AAN12054 AAN12054.1 AAN12055 AAN12055.1 AAN12056 AAN12056.1 AI388160 AI520594 AI946191 AQ025307 AW943534 AY061458 BZ748759 CZ466798 CZ474145 U59476 Entrez Gene - A searchable database of RefSeq genes. • 38811 UniProtKB/TrEMBL • Q94901
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, CCHC-type (IPR001878) Nucleotide-binding, alpha-beta plait (IPR012677) Zinc finger, CCHC retroviral-type (IPR013084)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64251 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011640 DroID - A comprehensive database of gene and protein interactions. • FBgn0011640 DRSC - Results from RNAi screens. • FBgn0011640 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011640 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8597-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011640 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38811 InParanoid A subset of ortholog calls from InParanoid. • AAEL013982-PA Aedes aegypti (mosquito) XP_623841.2 Apis mellifera (honey bee) XP_001943947.1 Acyrthosiphon pisum (pea aphid) 32353 Batrachochytrium dendrobatidis (chytrid fungus) 83339 Branchiostoma floridae (lancelet) 83361 Branchiostoma floridae (lancelet) BGIBMGA007410-PA Bombyx mori (silk worm) ENSBTAP00000000541 Bos taurus (bovine) ENSBTAP00000007153 Bos taurus (bovine) CBP33695 Caenorhabditis briggsae (nematode) CE15447 Caenorhabditis elegans (worm) ENSCAFP00000018230 Canis familiaris (dog) CPIJ009028 Culex pipens (mosquito) ENSCPOP00000012327 Cavia porcellus (guinea pig) 224043 Capitella spl (polychaete worm) ENSDARP00000071862 Danio rerio (zebra fish) ENSECAP00000020394 Equus caballus (horse) ENSGACP00000001061 Gymnopilus aculeatus (mushroom) ENSGALP00000029322 Gallus gallus (chicken) ENSP00000310471 Homo sapiens (human) ISCW015020-PA Ixodes scapularis (deer tick) KLLA0F18216g Kluyveromyces lactis (yeast) ENSMODP00000010014 Monodelphis domestica (gray opossum) ENSMMUP00000013865 Macaca mulatta (rhesus monkey) ENSMUSP00000038256 Mus musculus (house mouse) ENSOANP00000004983 Ornithorynchus anatinus (platypus) ENSOANP00000017481 Ornithorynchus anatinus (platypus) ENSORLP00000015616 Oryzias latipes (japanese killifish) PHUM005048-PA Pediculus humanus (human body louse) ENSPPYP00000003487 Pongo pygmaeus (orangutan) 244286 Populus trichocarpa (black cottonwood) ENSPTRP00000006780 Pan troglodytes (chimpanzee) ENSRNOP00000026605 Rattus norvegicus (norway rat) Smp_079290.1 Schistosoma mansoni (trematode parasite) XP_001175941.1 Strongylocentrotus purpuratus (purple sea urchin) XP_970745.1 Tribolium castaneum (red flour beetle) Tc00.1047053509317.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511621.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000000403 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033958 Takifugu rubripes (pufferfish Takifugu) 82538.m00091 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008271 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38811 modMine - Data generated by the modENCODE project. • FBgn0011640 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23065 LH22860 FBgn0081181 CPIJ009028 BGIBMGA007410 ACYPI010087 ACYPI008424 ACYPI003756 GB13251 AAEL013982 PB23863 PHUM127250 GLEAN_06476
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG8597 (Ducat et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Herold et al., 2009, Cammarato et al., 2011) dLARK (Huang et al., 2007) LARK (Levine, 2004) Lark (Lai et al., 2003, Ducat et al., 2008) lark (Schroeder et al., 2003, Arancio et al., 2010, McNeil et al., 2008, Martin et al., 2005, Kankel et al., 2007, Sofola et al., 2008, Newby and Jackson, 1996, Huang et al., 2009, Herold et al., 2009)
Name Synonym	lark (Newby and Jackson, 1995, McNeil et al., 2009, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 76 )
Generate a list of	All references relating to this gene ( 76 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 4 ) Review  ( 18 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 16 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 1 )
	Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...