FB2020_06, released Dec 22, 2020
Gene: Dmel\mas
FB2020_06, released Dec 22, 2020
Gene: Dmel\mas
Gene: Dmel\mas
Gene: Dmel\mas
Please see the JBrowse view of Dmel\mas for information on other features
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Gene model reviewed during 5.45
4.0 (northern blot)
None of the polypeptides share 100% sequence identity.
1047 (aa); 77, 35 (kD observed)
A 112kD proprotein is processed into two peptides of 35kD (amino-terminal) and 77kD (carboxy-terminal).
The 77kD mas protein is a carboxy-terminal peptide processed from the FBgn0011653:mas @ proprotein.
Proteolytically cleaved and thereafter secreted.
The CLIP domain consists of 37-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mas using the Feature Mapper tool.
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
mas is expressed in posterior midline glia but not in anterior midline glia in stage 12 embryos.
The 77kD mas protein appears to be secreted.
The 77kD mas peptide is detected in the attachment sites of somatic embryonic muscles starting in stage 16 and persisting until the beginning of pupation. It is thought to be secreted into the intercellular region of the attachment site by the epidermal cells. The polypeptide is also found in the tracheal lumen. In the CNS, the mas peptide is found in midline cells and in the axons of the longitudinal connectives, again consistent with it being secreted.
GBrowse - Visual display of RNA-Seq signals
View Dmel\mas in GBrowse 2
3-10
3-10
3-8.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
mas is expressed in relevant cell types during embryonic, larval and pupal life. Total loss of mas function in the embryo results in defects in the axonal connectivities of the motor as well as sensory axons. Defects in information processing by the neuronal pathways is the underlying cause for the aberrant taste behaviour exhibited by larvae and adults mutant for mas.
