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Gene: Dmel\Med

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General Information
Symbol
Dmel\Med
Species
D. melanogaster
Name
Medea
Annotation Symbol
CG1775
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011655
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Medea (Med) belongs to the highly conserved Smad family. Med can bind its siblings Mad or Smox to facilitate signal transduction for dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. [Date last reviewed: 2016-12-15]
Other Summaries
Also Known As
medea, l(3)SG70, l(3)11m-254, dSmad4
Key Links
Genomic Location
Cytogenetic map
100C7-100D1
Sequence location
3R:31,611,046..31,615,375 [+]
Recombination map
3-102
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
SMAD domain, Dwarfin-type; MAD homology 1, Dwarfin-type; SMAD/FHA domain superfamily; MAD homology, MH1; Dwarfin; SMAD-like domain superfamily; SMAD MH1 domain superfamily
Molecular Function (see GO section for details)
Experimental Evidence
protein binding; sequence-specific DNA binding
Predictions / Assertions
DNA binding; DNA-binding transcription factor activity; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
Summaries
Gene Group Membership
MAD HOMOLOGY DOMAIN TRANSCRIPTION FACTORS -
The Mother against Dpp (MAD) homology (MH) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These members contain an N-terminal sequence-specific DNA-binding MH1 and a C-terminal MH2 domain that mediates the formation of oligomeric complexes. (Adapted from FBrf0208242 and FBrf0206210).
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
l(3)SG70
Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal, and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but with reduced frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. Larval ganglion mitoses exhibit weak effect on chromosome condensation as well as chromosome breakage (Gatti and Baker, 1989, Genes Dev. 3: 438-53); salivary chromosomes appear normal.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Med or the JBrowse view of Dmel\Med for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.48
Gene model reviewed during 5.46
Gene model reviewed during 5.53
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Med-RA
FBtr0085815
NM_079871
3250
771
Med-RB
FBtr0085816
NM_170559
3028
697
Med-RC
FBtr0337030
NM_170560
3425
771
Additional Transcript Data and Comments
Reported size (kB)
2.8 (longest cDNA)
(Das et al., 1998)
3.1-3.3 (northern blot)
(Hudson et al., 1998)
3.3 (longest cDNA)
(Wisotzkey et al., 1998)
3.03 (longest cDNA)
(Xu et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Med-PA
FBpp0085176
81.6
771
7.60
NP_524610
AAF57172
Med-PB
FBpp0085177
73.7
697
7.45
NP_733438
AAN14277
Med-PC
FBpp0307959
81.6
771
7.60
NP_733439
AAN14278
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

771 aa isoforms: Med-PA, Med-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
771 (aa)
(Das et al., 1998, Hudson et al., 1998, Wisotzkey et al., 1998)
697 (aa)
(Xu et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Med using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Wisotzkey et al., 1998)
inferred from physical interaction with UniProtKB:Q9NB71
(assigned by UniProt )
(McCabe et al., 2004)
sequence-specific DNA binding
inferred from direct assay
(Weiss et al., 2010)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
DNA binding
traceable author statement
(Kawabata and Miyazono, 1999)
DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR013019
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
non-traceable author statement
(Kawabata and Miyazono, 1999)
Biological Process (17 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
cell proliferation
inferred from mutant phenotype
(Marquez et al., 2001)
dorsal/ventral axis specification
inferred from mutant phenotype
(Hudson et al., 1998)
dorsal/ventral pattern formation
inferred from mutant phenotype
(Wisotzkey et al., 1998)
germ-line stem cell division
inferred from mutant phenotype
(Xie and Spradling, 1998)
germ-line stem cell population maintenance
inferred from mutant phenotype
(Xie and Spradling, 1998)
imaginal disc-derived leg morphogenesis
inferred from mutant phenotype
(Marquez et al., 2001)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Marquez et al., 2001)
neuron development
inferred from mutant phenotype
(Zheng et al., 2006)
ovarian follicle cell development
inferred from mutant phenotype
(Kirilly et al., 2005)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(McCabe et al., 2004)
retinal ganglion cell axon guidance
inferred from mutant phenotype
(Yoshida et al., 2005)
somatic stem cell population maintenance
inferred from mutant phenotype
(Kirilly et al., 2005)
transforming growth factor beta receptor signaling pathway
inferred from mutant phenotype
(Marquez et al., 2001, Hudson et al., 1998)
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Hudson et al., 1998, Wisotzkey et al., 1998)
inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
(Hudson et al., 1998)
inferred from genetic interaction with FLYBASE:zen; FB:FBgn0004053
(Hudson et al., 1998)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
BMP signaling pathway
traceable author statement
(Raftery and Sutherland, 2003)
germ-line stem cell division
traceable author statement
(Lin, 2002)
heart development
traceable author statement
(Cripps and Olson, 2002, Chen and Fishman, 2000)
negative regulation of salivary gland boundary specification
traceable author statement
(Bradley et al., 2001)
regulation of transcription, DNA-templated
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
non-traceable author statement
(Affolter et al., 2001)
transforming growth factor beta receptor signaling pathway
traceable author statement
(Lall and Patel, 2001)
inferred from sequence or structural similarity with HGNC:6770
(Hudson et al., 1998)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Wisotzkey et al., 1998)
nucleus
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Wisotzkey et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleus
traceable author statement
(Affolter et al., 2001)
transcription factor complex
inferred from electronic annotation with InterPro:IPR013019
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4
(Wisotzkey et al., 1998)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7
organism | anterior
(Wisotzkey et al., 1998)
mesoderm
(Wisotzkey et al., 1998)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
endoderm
(Wisotzkey et al., 1998)
ectoderm
(Wisotzkey et al., 1998)
embryonic stage 14 -- 17
presumptive embryonic/larval central nervous system | restricted
(Wisotzkey et al., 1998)
embryonic stage 16
embryonic midgut constriction 2
(Wisotzkey et al., 1998)
Additional Descriptive Data
Med transcript expression is widespread in the stage 4 embryo. At stage 7, expression is detected in the mesoderm and in the anterior embryo. At stage 14, expression is detected in the ectoderm, endoderm, and the central nervous system. At stage 16, the CNS, the second midgut constriction, as well as other tissues, accumulate Med transcript.
(Wisotzkey et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S9 -- S10
centripetally migrating follicle cell
(Muzzopappa and Wappner, 2005)
oogenesis stage S10
follicle cell
(Muzzopappa and Wappner, 2005)
Additional Descriptive Data
Med protein is localized at oogenesis stage S9 to anterior follicle cells that migrate towards the oocyte, and at stage S10 to all follicle cells, with stronger expression observed in stretch cells.
(Muzzopappa and Wappner, 2005)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Wisotzkey et al., 1998)
nucleus
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Wisotzkey et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Med in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Allele of Med
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Med1
1
Yes
Med13
1
Yes
Med15
0
Yes
Med4
hypomorphic allele - genetic evidence
0
--
Med5
2
--
Med3
loss of function allele
0
--
Med8
loss of function allele
    0
    Yes
    Med26
    0
    Yes
    Med2
    0
    --
    Med7
    0
    Yes
    Med17
    0
    Yes
    Med3R-70-38
    0
    --
    Med14
    0
    Yes
    Med24
    0
    --
    MedC246
    loss of function allele
      0
      Yes
      MedG112
        0
        Yes
        Medunspecified
          0
          --
          MedMB08684
            1
            Yes
            Med3R-50-13
            0
            --
            Med3R-56-35
            0
            --
            Med3R-58-36
            0
            --
            Med6
            0
            Yes
            Med11
            0
            Yes
            Med12
            0
            Yes
            Med16
            0
            Yes
            Med18
            0
            --
            Med19
            0
            Yes
            Med21
            0
            Yes
            Med22
              0
              --
              Med23
              0
              Yes
              Med25
              hypomorphic allele - genetic evidence
              0
              --
              Med27
                0
                --
                Medadro
                0
                --
                MedBH1
                0
                --
                Medc5
                0
                --
                Medc7
                0
                --
                MedD5
                0
                --
                MedES2
                0
                --
                MedES3
                0
                --
                MedK465
                  0
                  Yes
                  Other relevant insertions
                  insertion of mobile activating element
                  Name
                  Expression Data
                  P{GSV1}CycGC166
                  NA
                  Transgenic Constructs ( 15 )
                  For All Alleles Carried on Transgenic Constructs Show
                  Transgenic constructs containing/affecting coding region of Med
                  Allele of Med
                  Mutagen
                  Associated Transgenic Construct
                  Stocks
                  MedUAS.cSa
                  0
                  MedJF02218
                  1
                  MedGD1483
                  2
                  MedKK108412
                  1
                  MedGL01313
                  1
                  MedUAS.ORF.GW.Tag:HA
                  1
                  MedABC.Ubi-p63E.Tag:MYC
                  0
                  MedK738R.UASp
                  0
                  MedUASp.cSa
                  0
                  MedUbi-p63E.PD
                  0
                  MedfTRG00576.sfGFP-TVPTBF
                  1
                  MedsfGFP,Tag:FLAG
                  1
                  MedTOE.GS02061
                  1
                  MedUAS.GFP
                  0
                  MedVDRC.cUa
                  0
                  Transgenic constructs containing regulatory region of Med
                  Deletions and Duplications ( 11 )
                  Summary of Phenotypes
                  For more details about a specific phenotype click on the relevant allele symbol.
                  Lethality
                  Allele
                  lethal (with Df(3R)tll-e)
                  lethal (with Med1)
                  lethal (with Med5)
                  lethal (with Med13)
                  lethal (with Medadro)
                  lethal | maternal effect | recessive
                  lethal | recessive
                  lethal - all die before end of embryonic stage | germline clone | recessive | rescuable maternal effect
                  lethal - all die before end of embryonic stage | maternal effect
                  lethal - all die before end of embryonic stage | maternal effect | recessive
                  lethal - all die before end of larval stage | recessive
                  lethal - all die before end of pupal stage | recessive
                  lethal - all die during P-stage, with Scer\GAL4Mef2.PR
                  viable
                  viable, with Scer\GAL4tin.CΔ4
                  Other Phenotypes
                  Allele
                  cell growth defective | somatic clone
                  decreased cell number
                  decreased cell number | oogenesis | oogenesis | somatic clone
                  decreased occurrence of cell division | larval stage
                  decreased occurrence of cell division | oogenesis | oogenesis
                  mitotic cell cycle defective
                  neuroanatomy defective
                  neuroanatomy defective (with Df(3R)Kpn-A)
                  neuroanatomy defective (with Med3)
                  neuroanatomy defective (with MedC246)
                  neurophysiology defective
                  size defective
                  size defective | adult stage, with Scer\GAL4dsx.KI
                  size defective | adult stage, with Scer\GAL4esg.PU
                  size defective | larval stage
                  small body | larval stage (with Df(3R)Kpn-A)
                  some die during embryonic stage | maternal effect
                  some die during embryonic stage | recessive | maternal effect | recessive
                  some die during embryonic stage | recessive | rescuable maternal effect
                  some die during larval stage | recessive
                  some die during pupal stage | recessive
                  visible, with Scer\GAL4A9
                  visible, with Scer\GAL4Bx-MS1096
                  visible, with Scer\GAL4ptc-559.1
                  visible | recessive
                  visible | somatic clone
                  wild-type
                  Phenotype manifest in
                  Allele
                  adult thorax
                  amnioserosa
                  bouton
                  bouton (with Df(3R)Kpn-A)
                  bouton (with Med3)
                  bouton (with MedC246)
                  cell cycle
                  chorion | maternal effect | somatic clone
                  chromosome
                  crystal cell
                  dense core granule | adult stage, with Scer\GAL4NP0261
                  denticle belt
                  dorsal cluster neuron | somatic clone
                  egg operculum | maternal effect | somatic clone
                  embryonic/first instar larval cuticle
                  embryonic/first instar larval cuticle | maternal effect
                  embryonic/larval central nervous system
                  embryonic/larval midgut | embryonic stage
                  embryonic/larval somatic muscle (with Df(3R)Kpn-A)
                  embryonic epidermis
                  embryonic midgut constriction 2
                  eye | somatic clone
                  eye disc | somatic clone
                  eye photoreceptor cell stalk | somatic clone
                  fat body
                  female germline stem cell
                  femur
                  filzkorper
                  follicle cell | somatic clone
                  follicle stem cell | somatic clone
                  gastric caecum
                  germarium
                  imaginal disc
                  imaginal disc | larval stage
                  lamina | somatic clone
                  larval head | dorso-lateral | embryonic stage
                  larval head | embryonic stage
                  leg, with Scer\GAL4ptc-559.1
                  leg | ectopic, with Scer\GAL4ptc-559.1
                  lysosome | adult stage, with Scer\GAL4dsx.KI
                  male accessory gland secondary cell, with Scer\GAL4dsx.KI
                  male accessory gland secondary cell, with Scer\GAL4esg.PU
                  male accessory gland secondary cell, with Scer\GAL4NP0261
                  male germline stem cell | germline clone
                  morphogenetic furrow | somatic clone
                  multivesicular body | adult stage, with Scer\GAL4dsx.KI
                  neuromuscular junction
                  neuromuscular junction (with Df(3R)Kpn-A)
                  neuromuscular junction (with Med3)
                  neuromuscular junction (with MedC246)
                  nucleus | adult stage, with Scer\GAL4esg.PU
                  posterior crossvein
                  pretarsus
                  secretory vesicle | adult stage, with Scer\GAL4dsx.KI
                  synapse
                  tarsal segment 4
                  t-bar
                  tibia
                  wing, with Scer\GAL4A9
                  wing, with Scer\GAL4Bx-MS1096
                  wing, with Scer\GAL4nub-AC-62
                  wing, with Scer\GAL4ptc-559.1
                  wing | cell non-autonomous | somatic clone
                  wing | somatic clone
                  wing disc | somatic clone
                  wing hinge | cell autonomous | somatic clone
                  wing hinge | cell non-autonomous | somatic clone
                  wing margin | cell non-autonomous | somatic clone
                  wing vein, with Scer\GAL4nub-AC-62
                  wing vein | ectopic, with Scer\GAL4A9
                  wing vein | ectopic, with Scer\GAL4ptc-559.1
                  wing vein L4
                  Orthologs
                  Downloads
                  Download All DIOPT Orthologs
                  Download All OrthoDB Orthologs
                  Human Orthologs (via DIOPT v7.1)
                  Homo sapiens (Human) (8)
                  Species\Gene Symbol
                  Score
                  Best Score
                  Best Reverse Score
                  Source
                  Compara
                  eggNOG
                  Hieranoid
                  Homologene
                  Inparanoid
                  Isobase
                  OMA
                  OrthoDB
                  OrthoFinder
                  OrthoInspector
                  orthoMCL
                  Panther
                  Phylome
                  RoundUp
                  TreeFam
                  ZFIN
                  Alignment
                  Complementation?
                  Transgene?
                  Hsap\SMAD4
                  12 of 15
                  Yes
                  Yes
                   
                  Hsap\SMAD1
                  1 of 15
                  No
                  No
                   
                  Hsap\SMAD2
                  1 of 15
                  No
                  No
                   
                  Hsap\SMAD3
                  1 of 15
                  No
                  No
                   
                  Hsap\SMAD5
                  1 of 15
                  No
                  No
                  Hsap\SMAD6
                  1 of 15
                  No
                  No
                   
                  Hsap\SMAD7
                  1 of 15
                  No
                  No
                   
                  Hsap\SMAD9
                  1 of 15
                  No
                  No
                  Model Organism Orthologs (via DIOPT v7.1)
                  Mus musculus (laboratory mouse) (8)
                  Species\Gene Symbol
                  Score
                  Best Score
                  Best Reverse Score
                  Source
                  Compara
                  eggNOG
                  Hieranoid
                  Homologene
                  Inparanoid
                  Isobase
                  OMA
                  OrthoDB
                  OrthoFinder
                  OrthoInspector
                  orthoMCL
                  Panther
                  Phylome
                  RoundUp
                  TreeFam
                  ZFIN
                  Alignment
                  Complementation?
                  Transgene?
                  Mmus\Smad4
                  13 of 15
                  Yes
                  Yes
                  Mmus\Smad1
                  1 of 15
                  No
                  No
                  Mmus\Smad2
                  1 of 15
                  No
                  No
                  Mmus\Smad3
                  1 of 15
                  No
                  No
                  Mmus\Smad5
                  1 of 15
                  No
                  No
                  Mmus\Smad6
                  1 of 15
                  No
                  No
                  Mmus\Smad7
                  1 of 15
                  No
                  No
                  Mmus\Smad9
                  1 of 15
                  No
                  No
                  Rattus norvegicus (Norway rat) (8)
                  Rnor\Smad4
                  8 of 13
                  Yes
                  Yes
                  Rnor\LOC103691556
                  1 of 13
                  No
                  No
                  Rnor\Smad1
                  1 of 13
                  No
                  No
                  Rnor\Smad2
                  1 of 13
                  No
                  No
                  Rnor\Smad3
                  1 of 13
                  No
                  No
                  Rnor\Smad5
                  1 of 13
                  No
                  No
                  Rnor\Smad6
                  1 of 13
                  No
                  No
                  Rnor\Smad7
                  1 of 13
                  No
                  No
                  Xenopus tropicalis (Western clawed frog) (9)
                  Xtro\smad4.1
                  8 of 12
                  Yes
                  Yes
                  Xtro\smad4.2
                  3 of 12
                  No
                  Yes
                  Xtro\smad1
                  1 of 12
                  No
                  No
                  Xtro\smad2
                  1 of 12
                  No
                  No
                  Xtro\smad3
                  1 of 12
                  No
                  No
                  Xtro\smad6.2
                  1 of 12
                  No
                  No
                  Xtro\smad6
                  1 of 12
                  No
                  No
                  Xtro\smad7
                  1 of 12
                  No
                  No
                  Xtro\smad9
                  1 of 12
                  No
                  No
                  Danio rerio (Zebrafish) (12)
                  Drer\si:dkey-222b8.1
                  11 of 15
                  Yes
                  Yes
                  Drer\si:dkey-239n17.4
                  11 of 15
                  Yes
                  Yes
                  Drer\smad4a
                  10 of 15
                  No
                  Yes
                  Drer\gb:cr929477
                  7 of 15
                  No
                  Yes
                  Drer\smad2
                  1 of 15
                  No
                  No
                  Drer\smad3a
                  1 of 15
                  No
                  No
                  Drer\smad3b
                  1 of 15
                  No
                  No
                  Drer\smad5
                  1 of 15
                  No
                  No
                  Drer\smad6a
                  1 of 15
                  No
                  No
                  Drer\smad6b
                  1 of 15
                  No
                  No
                  Drer\smad7
                  1 of 15
                  No
                  No
                  Drer\smad9
                  1 of 15
                  No
                  No
                  Caenorhabditis elegans (Nematode, roundworm) (7)
                  Cele\sma-4
                  8 of 15
                  Yes
                  Yes
                  Cele\daf-3
                  5 of 15
                  No
                  Yes
                  Cele\daf-8
                  1 of 15
                  No
                  No
                  Cele\daf-14
                  1 of 15
                  No
                  No
                  Cele\sma-2
                  1 of 15
                  No
                  No
                  Cele\sma-3
                  1 of 15
                  No
                  No
                  Cele\tag-68
                  1 of 15
                  No
                  No
                  Arabidopsis thaliana (thale-cress) (0)
                  No orthologs reported.
                  Saccharomyces cerevisiae (Brewer's yeast) (0)
                  No orthologs reported.
                  Schizosaccharomyces pombe (Fission yeast) (0)
                  No orthologs reported.
                  Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919062J )
                  Organism
                  Common Name
                  Gene
                  AAA Syntenic Ortholog
                  Multiple Dmel Genes in this Orthologous Group
                  Drosophila melanogaster
                  fruit fly
                  Dmel\Med
                  Drosophila suzukii
                  Spotted wing Drosophila
                  Dsuz\DS10_00007391
                  Drosophila simulans
                  Dsim\GD21590
                  Drosophila sechellia
                  Dsec\GM16436
                  Drosophila erecta
                  Dere\GG11819
                  Drosophila yakuba
                  Dyak\GE10952
                  Drosophila ananassae
                  Dana\GF22974
                  Drosophila pseudoobscura pseudoobscura
                  Dpse\GA14643
                  Drosophila persimilis
                  Dper\GL23637
                  Drosophila willistoni
                  Dwil\GK11724
                  Drosophila virilis
                  Dvir\GJ23092
                  Drosophila mojavensis
                  Dmoj\GI23400
                  Drosophila grimshawi
                  Dgri\GH18642
                  Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915018A )
                  Organism
                  Common Name
                  Gene
                  Multiple Dmel Genes in this Orthologous Group
                  Musca domestica
                  House fly
                  Mdoa\17005647
                  Glossina morsitans
                  Tsetse fly
                  Gmor\GMOY010539
                  Lucilia cuprina
                  Australian sheep blowfly
                  Lcup\FF38_00266
                  Aedes aegypti
                  Yellow fever mosquito
                  Aaeg\AAEL013896
                  Anopheles darlingi
                  American malaria mosquito
                  Adar\ADAC007516
                  Anopheles gambiae
                  Malaria mosquito
                  Agam\AGAP002902
                  Culex quinquefasciatus
                  Southern house mosquito
                  Cqui\CPIJ002563
                  Culex quinquefasciatus
                  Southern house mosquito
                  Cqui\CPIJ002562
                  Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03OZ )
                  Organism
                  Common Name
                  Gene
                  Multiple Dmel Genes in this Orthologous Group
                  Bombyx mori
                  Silkmoth
                  Bmor\BGIBMGA010110
                  Danaus plexippus
                  Monarch butterfly
                  Dple\DPOGS207335-PA
                  Heliconius melpomene
                  Postman butterfly
                  Hmel\HMEL002203
                  Apis florea
                  Little honeybee
                  Aflo\3081814724
                  Apis mellifera
                  Western honey bee
                  Amel\GB50071
                  Bombus impatiens
                  Common eastern bumble bee
                  Bimp\BIMP16290
                  Bombus terrestris
                  Buff-tailed bumblebee
                  Bter\15205669
                  Linepithema humile
                  Argentine ant
                  Lhum\LH21571
                  Megachile rotundata
                  Alfalfa leafcutting bee
                  Mrot\MROTU:001a25
                  Nasonia vitripennis
                  Parasitic wasp
                  Nvit\Nasvi2EG006495
                  Dendroctonus ponderosae
                  Mountain pine beetle
                  Dpod\YQE_06624
                  Tribolium castaneum
                  Red flour beetle
                  Tcas\Med
                  Pediculus humanus
                  Human body louse
                  Phum\PHUM002670
                  Cimex lectularius
                  Bed bug
                  Clec\CLEC002593
                  Cimex lectularius
                  Bed bug
                  Clec\CLEC002594
                  Acyrthosiphon pisum
                  Pea aphid
                  Apim\ACYPI000365
                  Acyrthosiphon pisum
                  Pea aphid
                  Apim\ACYPI003759
                  Acyrthosiphon pisum
                  Pea aphid
                  Apim\ACYPI005550
                  Acyrthosiphon pisum
                  Pea aphid
                  Apim\ACYPI008450
                  Zootermopsis nevadensis
                  Nevada dampwood termite
                  Znev\Znev_02071
                  Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03M2 )
                  Organism
                  Common Name
                  Gene
                  Multiple Dmel Genes in this Orthologous Group
                  Strigamia maritima
                  European centipede
                  Smar\SMAR013850
                  Ixodes scapularis
                  Black-legged tick
                  Isca\ISCW007667
                  Ixodes scapularis
                  Black-legged tick
                  Isca\ISCW018468
                  Stegodyphus mimosarum
                  African social velvet spider
                  Smim\KFM60390.1
                  Tetranychus urticae
                  Two-spotted spider mite
                  Turt\tetur10g00400
                  Daphnia pulex
                  Water flea
                  Dpux\DAPPUDRAFT_304115
                  Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05Z9 )
                  Organism
                  Common Name
                  Gene
                  Multiple Dmel Genes in this Orthologous Group
                  Strongylocentrotus purpuratus
                  Purple sea urchin
                  Spur\Sp-Smad4
                  Ciona intestinalis
                  Vase tunicate
                  Cint\ENSCING00000005559
                  Human Disease Model Data
                  FlyBase Human Disease Model Reports
                  Alleles Reported to Model Human Disease (Disease Ontology)
                  Download
                  Models ( 1 )
                  Interactions ( 3 )
                  Allele
                  Disease
                  Interaction
                  References
                  Med13
                  ameliorates  muscular dystrophy
                  modeled by Scgδ840
                  (Goldstein et al., 2011)
                  ameliorates  cardiomyopathy
                  modeled by Scgδ840
                  (Goldstein et al., 2011)
                  Med15
                  ameliorates  muscular dystrophy
                  modeled by Scgδ840
                  (Goldstein et al., 2011)
                  Med17
                  ameliorates  muscular dystrophy
                  modeled by Scgδ840
                  (Goldstein et al., 2011)
                  Comments ( 1 )
                   
                  Med13 suppresses the heart tube dysfunction component of muscular dystrophy in Scgδ840 flies, as well as muscle dysfunction.
                  (Goldstein et al., 2011)
                  Human Orthologs (via DIOPT v7.1)
                  Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
                  Homo sapiens (Human)
                  Gene name
                  Score
                  OMIM
                  OMIM Phenotype
                  Complementation?
                  Transgene?
                  SMAD4; SMAD family member 4
                  12 of 15
                  600993
                   
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Med
                  suppressible
                  dpp
                  (Hudson et al., 1996)
                  Med
                  suppressible
                  fuss
                  (Fischer et al., 2012)
                  Med
                  suppressible
                  Smurf
                  (Podos et al., 2001)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  CycE
                  suppressible
                  Med|dpp
                  (Horsfield et al., 1998)
                  dpp
                  enhanceable
                  Med
                  (Takaesu et al., 2005, Hudson et al., 1998, Raftery et al., 1995)
                  dpp
                  suppressible
                  Med
                  (Bangi and Wharton, 2006, Wisotzkey et al., 1998)
                  dpp|faf
                  suppressible
                  Med
                  (Stinchfield et al., 2012)
                  dpp|lolal
                  suppressible
                  Med
                  (Quijano et al., 2016)
                  gbb
                  suppressible
                  Med
                  (Bangi and Wharton, 2006)
                  hiw
                  suppressible
                  Med
                  (McCabe et al., 2004)
                  Ras85D
                  enhanceable
                  Apc|Med|Pten
                  (Bangi et al., 2016)
                  Ras85D
                  enhanceable
                  Med|Pten|p53
                  (Bangi et al., 2016)
                  Ras85D
                  enhanceable
                  Apc|Med|p53
                  (Bangi et al., 2016)
                  Ras85D
                  enhanceable
                  Apc|Med|Pten|p53
                  (Bangi et al., 2016)
                  sax
                  suppressible
                  Med
                  (Das et al., 1998)
                  Scgδ
                  suppressible
                  Med
                  (Goldstein et al., 2011)
                  Snoo
                  suppressible
                  Med
                  (Barrio et al., 2007, Takaesu et al., 2006)
                  sog
                  enhanceable
                  Med
                  (Decotto and Ferguson, 2001)
                  sog
                  suppressible
                  Med
                  (Stinchfield et al., 2012)
                  spict
                  suppressible
                  Med
                  (Wang et al., 2007)
                  tkv
                  suppressible
                  Med
                  (Das et al., 1998)
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  Pathways
                  Gene Group - Pathway Membership (FlyBase)
                  External Data
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3R
                  Recombination map
                  3-102
                  Cytogenetic map
                  100C7-100D1
                  Sequence location
                  3R:31,611,046..31,615,375 [+]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  100C7-100D1
                  Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  100D-100D
                  (Hudson, 1997.12.18, Wisotzkey, 1997.10.1, Hudson et al., 1996)
                  100C4-100D2
                  (Raftery et al., 1996)
                  100D-100D
                  (determined by in situ hybridisation)
                  (Hudson et al., 1995)
                  Experimentally Determined Recombination Data
                  Location
                  3-102
                  (FlyBase, 2016)
                  3-99.1
                  (Comeron et al., 2012)
                  3-
                  (Hudson et al., 1996, Raftery et al., 1996)
                  3-130.2
                  (Gatti and Baker, 1989)
                  3-106
                  Left of (cM)
                  (Hudson et al., 1998)
                  (Wisotzkey et al., 1998)
                  Right of (cM)
                  (Decotto and Ferguson, 2001, Wisotzkey et al., 1998)
                  (Hudson et al., 1998)
                  Notes
                  Also mapped to 3-49.3 based on mapping of l(3)SG36, in error.
                  Stocks and Reagents
                  Stocks (14)
                  Genomic Clones (9)
                   

                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                  cDNA Clones (73)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequences
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for identity of: Med CG1775
                  (Zhao, 1999.11)
                  Source for database merge of
                  Source for merge of: Med E(zen)3
                  (Ferguson, 1998.8.7)
                  Source for merge of: Med anon- EST:Posey121
                  (Bayraktaroglu, 2000.11.2)
                  Additional comments
                  Other Comments
                  DNA-protein interactions: genome-wide binding profile assayed for Med protein in 2-3 hr embryos; see BDTNP1_TFBS_Med collection report.
                  (MacArthur et al., 2009)
                  RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
                  (Boutros et al., 2004)
                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                  (Kiger et al., 2003)
                  The brk silencer serves as a direct target for a protein complex consisting of Mad/Med and shn.
                  (Muller et al., 2003)
                  Overexpression of Med or Hsap\MADH4 in the wing and leg causes a similar phenotype. The leg phenotype caused by overexpression of Med or Hsap\MADH4 is similar to that caused by overexpression of Hsap\MADH6 or Hsap\MADH7. Overexpression of Med, Smox, Hsap\MADH2 or Hsap\MADH4 causes a similar phenotype in the wing.
                  (Marquez et al., 2001)
                  Hsap\MADH1 and Hsap\MADH4, as well as Mad and Med, can stimulate dpp signalling in limb development. Hsap\MADH2, Hsap\MADH4 and Med stimulate activin-β- rather than dpp-mediated cell proliferation. Med can signal for both TGF-beta families - Dpp/BMP signalling Smads and TGF-beta/Activin Smads.
                  (Marquez et al., 2001)
                  One of five genes identified as encoding downstream components of the dpp signalling cascade which is necessary for blocking salivary gland gene activation by Scr in the dorsal region of parasegment 2. Med function is required to block salivary gland formation in dorsal regions of PS2.
                  (Henderson et al., 1999)
                  Loss of function alleles of tkv, put, Mad, Med and shn suppress the CycEJP mutant eye phenotype in combination with dppd-ho.
                  (Horsfield et al., 1998)
                  Med is required for both embryonic and imaginal disc patterning. Med may have two independently mutable functions in patterning the embryonic ectoderm. Med acts downstream of tkv.
                  (Hudson et al., 1998)
                  Complete elimination of maternal and zygotic Med activity in the early embryo produces a ventralised phenotype identical to that of null dpp mutants, suggesting that Med is required for all dpp-dependent signaling in embryonic dorsal-ventral patterning.
                  (Hudson et al., 1998)
                  Mutants show no interaction with Df(2R)Pcl11B or Df(3L)66C-G28.
                  (Nicholls and Gelbart, 1998)
                  Med functions in dpp signaling. Med protein is localised in the cytoplasm, is not regulated by phosphorylation, and requires physical association with Mad protein for nuclear translocation. Mad mediated nuclear translocation is essential for Med function.
                  (Wisotzkey et al., 1998)
                  Dominant enhancer of zen.
                  (Hudson et al., 1995)
                  Med gene was identified in screens for mutations that decrease apparent activity of the dpp signal in the embryonic ectoderm.
                  (Raftery et al., 1995)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 80 )
                  Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMine - An integrated database for Drosophila genomics
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Synonyms and Secondary IDs (20)
                  Reported As
                  Symbol Synonym
                  CG1775
                  (Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Molnar et al., 2006)
                  E(zen)3
                  MED
                  (Blatti et al., 2015, Restrepo et al., 2014, Slattery et al., 2014, Cheng et al., 2013, MacArthur et al., 2009)
                  Med
                  (Ahmed-de-Prado and Baonza, 2018, Li et al., 2018, Powers and Srivastava, 2018, Wang et al., 2018, Follansbee et al., 2017, Houtz et al., 2017, Jeibmann et al., 2017, Transgenic RNAi Project members, 2017-, Altenhein et al., 2016, Mbodj et al., 2016, Quijano et al., 2016, Sarov et al., 2016, Bivik et al., 2015, Chen et al., 2015, Newton et al., 2015, Schertel et al., 2015, Zhou et al., 2015, Deshpande et al., 2014, Esteves et al., 2014, Jiang and Singh, 2014, Oh et al., 2014, Pichaud, 2014, Beckwith et al., 2013, Curtis et al., 2013, Li and Gilmour, 2013, Saunders et al., 2013, Webber et al., 2013, Fischer et al., 2012, Holmqvist et al., 2012, Kvon et al., 2012, Spokony and White, 2012.11.14, Stinchfield et al., 2012, Takaesu et al., 2012, Harris and Ashe, 2011, Li et al., 2011, Oh and Irvine, 2011, Quijano et al., 2011, Toku et al., 2011, Ball et al., 2010, Blanco et al., 2010, Chen and Xu, 2010, Dworkin et al., 2009, Lembong et al., 2009, Liu et al., 2009, Casas-Tinto et al., 2008, Christoforou et al., 2008, Miles et al., 2008, Ng, 2008, Pinto et al., 2008, Yakoby et al., 2008, Yao et al., 2008, Beltran et al., 2007, Gao and Laughon, 2007, Li et al., 2007, Shravage et al., 2007, Walsh and Carroll, 2007, Wang et al., 2007, Bangi and Wharton, 2006, Bernardi et al., 2006, Davidson and Erwin, 2006, Gao and Laughon, 2006, Molnar et al., 2006, Sotillos and de Celis, 2006, Takaesu et al., 2006, Yao et al., 2006, Gao et al., 2005, Kirilly et al., 2005, Marques, 2005, Xie et al., 2005, Yamashita et al., 2005, Pyrowolakis et al., 2004, Gim et al., 2001, Kyoda et al., 2000, Pickeral et al., 2000)
                  Medea
                  (Romero-Pozuelo et al., 2017, Niwa and Niwa, 2016, Urrutia et al., 2016, Van Bortle et al., 2015, Yamanaka et al., 2013, Raftery and Umulis, 2012)
                  SMAD4
                  (Takaesu et al., 2005)
                  Smad4
                  (Chen and Xu, 2010)
                  anon-EST:Posey121
                  dSmad4
                  (Bangi et al., 2016, Xu et al., 1998)
                  l(3)11m-254
                  (Castellanos et al., 2008, Gatti and Baker, 1989)
                  l(3)12m-137
                  (Gatti and Baker, 1989)
                  l(3)SG36
                  l(3)SG70
                  (Cohen, 1993, Gatti and Baker, 1989)
                  l(3)XIIm137
                  med
                  (Wells et al., 2017, Moulton and Letsou, 2016, Ayyaz et al., 2015, Kang et al., 2014, Marinho et al., 2013, Nègre et al., 2011, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Jiang et al., 2008, Ng, 2008, Wang et al., 2008, Kalinovsky and Scheiffele, 2004, Luschnig et al., 2004, Luschnig et al., 2004, McCabe et al., 2002, Baonza and Freeman, 2001, Dequier et al., 2001, Reiter et al., 2001, Horsfield et al., 1998)
                  medea
                  (Garaulet et al., 2016, Ayyaz et al., 2015, Eaton and Davis, 2005, Deng and Lin, 2001, Kockel et al., 2001, Affolter, 2000, Chen and Fishman, 2000, Potter et al., 2000, Henderson and Andrew, 1998, Haerry et al., 1996)
                  smad4
                  (Ayyaz et al., 2015)
                  Name Synonyms
                  Medea
                  (Upadhyay et al., 2017, Grill et al., 2016, Bier and De Robertis, 2015, Newton et al., 2015, Li et al., 2014, Mannervik, 2014, Zhang et al., 2014, Bausek, 2013, Doumpas et al., 2013, Holmqvist et al., 2012, Sun et al., 2012, Eivers et al., 2011, Eliazer and Buszczak, 2011, Goldstein et al., 2011, Hamaratoglu et al., 2011, Harris and Ashe, 2011, Ball et al., 2010, Bryk et al., 2010, Chen and Xu, 2010, Quijano et al., 2010, Sander et al., 2010, Wagner et al., 2010, Weiss et al., 2010, Lembong et al., 2009, MacArthur et al., 2009, Campbell and Moser, 2008, Jiang et al., 2008, Kamiya et al., 2008, Miles et al., 2008, Miles et al., 2008, Ng, 2008, Padgett, 2008.6.25, Pinto et al., 2008, Warrior et al., 2008, Yakoby et al., 2008, Yao et al., 2008, Barrio et al., 2007, Fuller and Spradling, 2007, Gao and Laughon, 2007, Lilja et al., 2007, Newfeld et al., 2007, Pistillo and Desplan, 2007, Pollard et al., 2007, Potthoff and Olson, 2007, Walsh and Carroll, 2007, Wang et al., 2007, Bernardi et al., 2006, Gao and Laughon, 2006, Li and Li, 2006, Lin et al., 2006, Marques, 2005, Stathopoulos and Levine, 2005, Yamashita et al., 2005, Stefancsik and Sarkar, 2003, Gim et al., 2001, Evangelista et al., 1998, Padgett, 1998.1.7, Padgett et al., 1998, Sutherland and Raftery, 1998, Takase, 1998.4.3, Wisotzkey et al., 1997, Xu, 1997.8.16, Yin, 1997.8.16)
                  Media
                  (Akasaka et al., 2006)
                  lethal(3)SG36
                  lethal(3)SG70
                  medea
                  (Richard et al., 2017, Marinho et al., 2013, Fischer et al., 2012, Nagel et al., 2012, Wang et al., 2007, Nakayama et al., 2006, Eaton and Davis, 2005)
                  Secondary FlyBase IDs
                  • FBgn0002479
                  • FBgn0002509
                  • FBgn0013946
                  • FBgn0027760
                  Datasets (2)
                  Study focus (2)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  • bait_protein
                  BDTNP_TFBS
                  ChIP characterization of transcription factor genome binding, Berkeley Drosophila Transcription Factor Network Project.
                  • bait_protein
                  modENCODE_regulation_TFs
                  Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
                  References (360)