General Information
Symbol
Dmel\Med
Species
D. melanogaster
Name
Medea
Annotation Symbol
CG1775
Feature Type
FlyBase ID
FBgn0011655
Gene Model Status
Stock Availability
Gene Snapshot
Medea (Med) belongs to the highly conserved Smad family. Med can bind its siblings Mad or Smox to facilitate signal transduction for dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. [Date last reviewed: 2016-12-15]
Also Known As
medea, l(3)SG70, l(3)11m-254, dSmad4
Genomic Location
Cytogenetic map
Sequence location
3R:31,611,046..31,615,375 [+]
Recombination map
3-102
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Summaries
Gene Group Membership
MAD HOMOLOGY DOMAIN TRANSCRIPTION FACTORS -
The Mother against Dpp (MAD) homology (MH) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These members contain an N-terminal sequence-specific DNA-binding MH1 and a C-terminal MH2 domain that mediates the formation of oligomeric complexes. (Adapted from FBrf0208242 and FBrf0206210).
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
l(3)SG70
Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal, and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but with reduced frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. Larval ganglion mitoses exhibit weak effect on chromosome condensation as well as chromosome breakage (Gatti and Baker, 1989, Genes Dev. 3: 438-53); salivary chromosomes appear normal.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Med or the JBrowse view of Dmel\Med for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.48
Gene model reviewed during 5.46
Gene model reviewed during 5.53
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0085815
3250
771
FBtr0085816
3028
697
FBtr0337030
3425
771
Additional Transcript Data and Comments
Reported size (kB)
2.8 (longest cDNA)
3.1-3.3 (northern blot)
3.3 (longest cDNA)
3.03 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085176
81.6
771
7.60
FBpp0085177
73.7
697
7.45
FBpp0307959
81.6
771
7.60
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

771 aa isoforms: Med-PA, Med-PC
Additional Polypeptide Data and Comments
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Med using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
inferred from physical interaction with UniProtKB:Q9NB71
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Biological Process (17 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
traceable author statement
inferred from electronic annotation with InterPro:IPR013019
(assigned by InterPro )
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

Additional Descriptive Data
Med transcript expression is widespread in the stage 4 embryo. At stage 7, expression is detected in the mesoderm and in the anterior embryo. At stage 14, expression is detected in the ectoderm, endoderm, and the central nervous system. At stage 16, the CNS, the second midgut constriction, as well as other tissues, accumulate Med transcript.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Med protein is localized at oogenesis stage S9 to anterior follicle cells that migrate towards the oocyte, and at stage S10 to all follicle cells, with stronger expression observed in stretch cells.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Med in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Allele of Med
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    Yes
      0
      --
        0
        --
          0
          Yes
          Other relevant insertions
          insertion of mobile activating element
          Name
          Expression Data
          Transgenic Constructs ( 15 )
          For All Alleles Carried on Transgenic Constructs Show
          Transgenic constructs containing/affecting coding region of Med
          Allele of Med
          Mutagen
          Associated Transgenic Construct
          Stocks
          Transgenic constructs containing regulatory region of Med
          Deletions and Duplications ( 11 )
          Summary of Phenotypes
          For more details about a specific phenotype click on the relevant allele symbol.
          Lethality
          Allele
          Other Phenotypes
          Allele
          Phenotype manifest in
          Allele
          Orthologs
          Human Orthologs (via DIOPT v7.1)
          Homo sapiens (Human) (8)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Alignment
          Complementation?
          Transgene?
          12 of 15
          Yes
          Yes
           
          1 of 15
          No
          No
           
          1 of 15
          No
          No
           
          1 of 15
          No
          No
           
          1 of 15
          No
          No
          1 of 15
          No
          No
           
          1 of 15
          No
          No
           
          1 of 15
          No
          No
          Model Organism Orthologs (via DIOPT v7.1)
          Mus musculus (laboratory mouse) (8)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Alignment
          Complementation?
          Transgene?
          13 of 15
          Yes
          Yes
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          Rattus norvegicus (Norway rat) (8)
          8 of 13
          Yes
          Yes
          1 of 13
          No
          No
          1 of 13
          No
          No
          1 of 13
          No
          No
          1 of 13
          No
          No
          1 of 13
          No
          No
          1 of 13
          No
          No
          1 of 13
          No
          No
          Xenopus tropicalis (Western clawed frog) (9)
          8 of 12
          Yes
          Yes
          3 of 12
          No
          Yes
          1 of 12
          No
          No
          1 of 12
          No
          No
          1 of 12
          No
          No
          1 of 12
          No
          No
          1 of 12
          No
          No
          1 of 12
          No
          No
          1 of 12
          No
          No
          Danio rerio (Zebrafish) (12)
          11 of 15
          Yes
          Yes
          11 of 15
          Yes
          Yes
          10 of 15
          No
          Yes
          7 of 15
          No
          Yes
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          Caenorhabditis elegans (Nematode, roundworm) (7)
          8 of 15
          Yes
          Yes
          5 of 15
          No
          Yes
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          1 of 15
          No
          No
          Arabidopsis thaliana (thale-cress) (0)
          No orthologs reported.
          Saccharomyces cerevisiae (Brewer's yeast) (0)
          No orthologs reported.
          Schizosaccharomyces pombe (Fission yeast) (0)
          No orthologs reported.
          Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919062J )
          Organism
          Common Name
          Gene
          AAA Syntenic Ortholog
          Multiple Dmel Genes in this Orthologous Group
          Drosophila melanogaster
          fruit fly
          Drosophila suzukii
          Spotted wing Drosophila
          Drosophila simulans
          Drosophila sechellia
          Drosophila erecta
          Drosophila yakuba
          Drosophila ananassae
          Drosophila pseudoobscura pseudoobscura
          Drosophila persimilis
          Drosophila willistoni
          Drosophila virilis
          Drosophila mojavensis
          Drosophila grimshawi
          Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915018A )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Musca domestica
          House fly
          Glossina morsitans
          Tsetse fly
          Lucilia cuprina
          Australian sheep blowfly
          Aedes aegypti
          Yellow fever mosquito
          Anopheles darlingi
          American malaria mosquito
          Anopheles gambiae
          Malaria mosquito
          Culex quinquefasciatus
          Southern house mosquito
          Culex quinquefasciatus
          Southern house mosquito
          Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03OZ )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Bombyx mori
          Silkmoth
          Danaus plexippus
          Monarch butterfly
          Heliconius melpomene
          Postman butterfly
          Apis florea
          Little honeybee
          Apis mellifera
          Western honey bee
          Bombus impatiens
          Common eastern bumble bee
          Bombus terrestris
          Buff-tailed bumblebee
          Linepithema humile
          Argentine ant
          Megachile rotundata
          Alfalfa leafcutting bee
          Nasonia vitripennis
          Parasitic wasp
          Dendroctonus ponderosae
          Mountain pine beetle
          Tribolium castaneum
          Red flour beetle
          Pediculus humanus
          Human body louse
          Cimex lectularius
          Bed bug
          Cimex lectularius
          Bed bug
          Acyrthosiphon pisum
          Pea aphid
          Acyrthosiphon pisum
          Pea aphid
          Acyrthosiphon pisum
          Pea aphid
          Acyrthosiphon pisum
          Pea aphid
          Zootermopsis nevadensis
          Nevada dampwood termite
          Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03M2 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strigamia maritima
          European centipede
          Ixodes scapularis
          Black-legged tick
          Ixodes scapularis
          Black-legged tick
          Stegodyphus mimosarum
          African social velvet spider
          Tetranychus urticae
          Two-spotted spider mite
          Daphnia pulex
          Water flea
          Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05Z9 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strongylocentrotus purpuratus
          Purple sea urchin
          Ciona intestinalis
          Vase tunicate
          Human Disease Model Data
          FlyBase Human Disease Model Reports
          Alleles Reported to Model Human Disease (Disease Ontology)
          Download
          Models ( 1 )
          Interactions ( 3 )
          Allele
          Disease
          Interaction
          References
          Comments ( 1 )
           
          Med13 suppresses the heart tube dysfunction component of muscular dystrophy in Scgδ840 flies, as well as muscle dysfunction.
          Human Orthologs (via DIOPT v7.1)
          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement

          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Pathways
          Gene Group - Pathway Membership (FlyBase)
          External Data
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map
          3-102
          Cytogenetic map
          Sequence location
          3R:31,611,046..31,615,375 [+]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          100C7-100D1
          Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          100D-100D
          (determined by in situ hybridisation)
          Experimentally Determined Recombination Data
          Notes
          Also mapped to 3-49.3 based on mapping of l(3)SG36, in error.
          Stocks and Reagents
          Stocks (14)
          Genomic Clones (9)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (73)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: Med CG1775
          Source for database merge of
          Source for merge of: Med E(zen)3
          Source for merge of: Med anon- EST:Posey121
          Additional comments
          Other Comments
          DNA-protein interactions: genome-wide binding profile assayed for Med protein in 2-3 hr embryos; see BDTNP1_TFBS_Med collection report.
          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          The brk silencer serves as a direct target for a protein complex consisting of Mad/Med and shn.
          Overexpression of Med or Hsap\MADH4 in the wing and leg causes a similar phenotype. The leg phenotype caused by overexpression of Med or Hsap\MADH4 is similar to that caused by overexpression of Hsap\MADH6 or Hsap\MADH7. Overexpression of Med, Smox, Hsap\MADH2 or Hsap\MADH4 causes a similar phenotype in the wing.
          Hsap\MADH1 and Hsap\MADH4, as well as Mad and Med, can stimulate dpp signalling in limb development. Hsap\MADH2, Hsap\MADH4 and Med stimulate activin-β- rather than dpp-mediated cell proliferation. Med can signal for both TGF-beta families - Dpp/BMP signalling Smads and TGF-beta/Activin Smads.
          One of five genes identified as encoding downstream components of the dpp signalling cascade which is necessary for blocking salivary gland gene activation by Scr in the dorsal region of parasegment 2. Med function is required to block salivary gland formation in dorsal regions of PS2.
          Loss of function alleles of tkv, put, Mad, Med and shn suppress the CycEJP mutant eye phenotype in combination with dppd-ho.
          Med is required for both embryonic and imaginal disc patterning. Med may have two independently mutable functions in patterning the embryonic ectoderm. Med acts downstream of tkv.
          Complete elimination of maternal and zygotic Med activity in the early embryo produces a ventralised phenotype identical to that of null dpp mutants, suggesting that Med is required for all dpp-dependent signaling in embryonic dorsal-ventral patterning.
          Mutants show no interaction with Df(2R)Pcl11B or Df(3L)66C-G28.
          Med functions in dpp signaling. Med protein is localised in the cytoplasm, is not regulated by phosphorylation, and requires physical association with Mad protein for nuclear translocation. Mad mediated nuclear translocation is essential for Med function.
          Dominant enhancer of zen.
          Med gene was identified in screens for mutations that decrease apparent activity of the dpp signal in the embryonic ectoderm.
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 80 )
          Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Synonyms and Secondary IDs (20)
          Reported As
          Symbol Synonym
          E(zen)3
          Med
          (Ahmed-de-Prado and Baonza, 2018, Li et al., 2018, Powers and Srivastava, 2018, Wang et al., 2018, Follansbee et al., 2017, Houtz et al., 2017, Jeibmann et al., 2017, Transgenic RNAi Project members, 2017-, Altenhein et al., 2016, Mbodj et al., 2016, Quijano et al., 2016, Sarov et al., 2016, Bivik et al., 2015, Chen et al., 2015, Newton et al., 2015, Schertel et al., 2015, Zhou et al., 2015, Deshpande et al., 2014, Esteves et al., 2014, Jiang and Singh, 2014, Oh et al., 2014, Pichaud, 2014, Beckwith et al., 2013, Curtis et al., 2013, Li and Gilmour, 2013, Saunders et al., 2013, Webber et al., 2013, Fischer et al., 2012, Holmqvist et al., 2012, Kvon et al., 2012, Spokony and White, 2012.11.14, Stinchfield et al., 2012, Takaesu et al., 2012, Harris and Ashe, 2011, Li et al., 2011, Oh and Irvine, 2011, Quijano et al., 2011, Toku et al., 2011, Ball et al., 2010, Blanco et al., 2010, Chen and Xu, 2010, Dworkin et al., 2009, Lembong et al., 2009, Liu et al., 2009, Casas-Tinto et al., 2008, Christoforou et al., 2008, Miles et al., 2008, Ng, 2008, Pinto et al., 2008, Yakoby et al., 2008, Yao et al., 2008, Beltran et al., 2007, Gao and Laughon, 2007, Li et al., 2007, Shravage et al., 2007, Walsh and Carroll, 2007, Wang et al., 2007, Bangi and Wharton, 2006, Bernardi et al., 2006, Davidson and Erwin, 2006, Gao and Laughon, 2006, Molnar et al., 2006, Sotillos and de Celis, 2006, Takaesu et al., 2006, Yao et al., 2006, Gao et al., 2005, Kirilly et al., 2005, Marques, 2005, Xie et al., 2005, Yamashita et al., 2005, Pyrowolakis et al., 2004, Gim et al., 2001, Kyoda et al., 2000, Pickeral et al., 2000)
          anon-EST:Posey121
          l(3)SG36
          l(3)XIIm137
          Name Synonyms
          lethal(3)SG36
          lethal(3)SG70
          Secondary FlyBase IDs
          • FBgn0002479
          • FBgn0002509
          • FBgn0013946
          • FBgn0027760
          Datasets (2)
          Study focus (2)
          Experimental Role
          Project
          Project Type
          Title
          • bait_protein
          ChIP characterization of transcription factor genome binding, Berkeley Drosophila Transcription Factor Network Project.
          • bait_protein
          Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
          References (360)