Open Close
General Information
Symbol
Dmel\Med
Species
D. melanogaster
Name
Medea
Annotation Symbol
CG1775
Feature Type
FlyBase ID
FBgn0011655
Gene Model Status
Stock Availability
Gene Snapshot
Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. [Date last reviewed: 2019-03-14]
Also Known As

l(3)SG70, l(3)11m-254, dSmad4

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:31,611,046..31,615,375 [+]
Recombination map

3-102

RefSeq locus
NT_033777 REGION:31611046..31615375
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
MAD HOMOLOGY DOMAIN TRANSCRIPTION FACTORS -
The Mother against Dpp (MAD) homology (MH) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These members contain an N-terminal sequence-specific DNA-binding MH1 and a C-terminal MH2 domain that mediates the formation of oligomeric complexes. (Adapted from FBrf0208242 and FBrf0206210).
Pathway (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Activin Signaling Pathway Core Components -
The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(3)SG70
Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal, and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but with reduced frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. Larval ganglion mitoses exhibit weak effect on chromosome condensation as well as chromosome breakage (Gatti and Baker, 1989, Genes Dev. 3: 438-53); salivary chromosomes appear normal.
Summary (Interactive Fly)

Smad family member - associates with Smad1 in response to Dpp or with Smad2 (Smox) in response to Activin ligands - dominant negative Smad4 blocks both BMP and activin responses - developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Med or the JBrowse view of Dmel\Med for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.46

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0085815
3250
771
FBtr0085816
3028
697
FBtr0337030
3425
771
Additional Transcript Data and Comments
Reported size (kB)

2.8 (longest cDNA)

3.1-3.3 (northern blot)

3.3 (longest cDNA)

3.03 (longest cDNA)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085176
81.6
771
7.60
FBpp0085177
73.7
697
7.45
FBpp0307959
81.6
771
7.60
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

771 aa isoforms: Med-PA, Med-PC
Additional Polypeptide Data and Comments
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Med using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (30 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (20 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
inferred from direct assay
inferred from physical interaction with FLYBASE:Smox; FB:FBgn0025800
inferred from direct assay
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

Additional Descriptive Data

Med transcript expression is widespread in the stage 4 embryo. At stage 7, expression is detected in the mesoderm and in the anterior embryo. At stage 14, expression is detected in the ectoderm, endoderm, and the central nervous system. At stage 16, the CNS, the second midgut constriction, as well as other tissues, accumulate Med transcript.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Med protein is localized at oogenesis stage S9 to anterior follicle cells that migrate towards the oocyte, and at stage S10 to all follicle cells, with stronger expression observed in stretch cells.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
inferred from direct assay
inferred from physical interaction with FLYBASE:Smox; FB:FBgn0025800
inferred from direct assay
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Med in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Med
Transgenic constructs containing regulatory region of Med
Deletions and Duplications ( 11 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
7 of 13
Yes
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
8 of 12
Yes
Yes
4 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (12)
12 of 15
Yes
Yes
10 of 15
No
Yes
9 of 15
No
Yes
9 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
8 of 15
Yes
Yes
5 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919062J )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915018A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03OZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03M2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05Z9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
3 of 10
3 of 10
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 3 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Activin Signaling Pathway Core Components -
The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Metabolic Pathways
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map

3-102

Cytogenetic map
Sequence location
3R:31,611,046..31,615,375 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
100C7-100D1
Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
100D-100D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Notes

Also mapped to 3-49.3 based on mapping of l(3)SG36, in error.

Stocks and Reagents
Stocks (18)
Genomic Clones (9)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (73)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: Med CG1775

Source for database merge of

Source for merge of: Med E(zen)3

Source for merge of: Med anon- EST:Posey121

Additional comments
Other Comments

DNA-protein interactions: genome-wide binding profile assayed for Med protein in 2-3 hr embryos; see BDTNP1_TFBS_Med collection report.

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

The brk silencer serves as a direct target for a protein complex consisting of Mad/Med and shn.

Overexpression of Med or Hsap\MADH4 in the wing and leg causes a similar phenotype. The leg phenotype caused by overexpression of Med or Hsap\MADH4 is similar to that caused by overexpression of Hsap\MADH6 or Hsap\MADH7. Overexpression of Med, Smox, Hsap\MADH2 or Hsap\MADH4 causes a similar phenotype in the wing.

Hsap\MADH1 and Hsap\MADH4, as well as Mad and Med, can stimulate dpp signalling in limb development. Hsap\MADH2, Hsap\MADH4 and Med stimulate activin-β- rather than dpp-mediated cell proliferation. Med can signal for both TGF-beta families - Dpp/BMP signalling Smads and TGF-beta/Activin Smads.

One of five genes identified as encoding downstream components of the dpp signalling cascade which is necessary for blocking salivary gland gene activation by Scr in the dorsal region of parasegment 2. Med function is required to block salivary gland formation in dorsal regions of PS2.

Loss of function alleles of tkv, put, Mad, Med and shn suppress the CycEJP mutant eye phenotype in combination with dppd-ho.

Med is required for both embryonic and imaginal disc patterning. Med may have two independently mutable functions in patterning the embryonic ectoderm. Med acts downstream of tkv.

Complete elimination of maternal and zygotic Med activity in the early embryo produces a ventralised phenotype identical to that of null dpp mutants, suggesting that Med is required for all dpp-dependent signaling in embryonic dorsal-ventral patterning.

Mutants show no interaction with Df(2R)Pcl11B or Df(3L)66C-G28.

Med functions in dpp signaling. Med protein is localised in the cytoplasm, is not regulated by phosphorylation, and requires physical association with Mad protein for nuclear translocation. Mad mediated nuclear translocation is essential for Med function.

Dominant enhancer of zen.

Med gene was identified in screens for mutations that decrease apparent activity of the dpp signal in the embryonic ectoderm.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 83 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (20)
Reported As
Symbol Synonym
E(zen)3
Med
(Drummond-Barbosa, 2019, Leiblich et al., 2019, Li et al., 2019, Meltzer et al., 2019, Shokri et al., 2019, Vuilleumier et al., 2019, Ahmed-de-Prado and Baonza, 2018, Bischof et al., 2018, Kwon et al., 2018, Liao et al., 2018, Li et al., 2018, Powers and Srivastava, 2018, Setiawan et al., 2018, Song et al., 2018, Wang et al., 2018, Follansbee et al., 2017, Houtz et al., 2017, Jeibmann et al., 2017, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Altenhein et al., 2016, Mbodj et al., 2016, Quijano et al., 2016, Sarov et al., 2016, Bivik et al., 2015, Chen et al., 2015, Newton et al., 2015, Schertel et al., 2015, Zhou et al., 2015, Deshpande et al., 2014, Esteves et al., 2014, Jiang and Singh, 2014, Oh et al., 2014, Pichaud, 2014, Beckwith et al., 2013, Curtis et al., 2013, Li and Gilmour, 2013, Saunders et al., 2013, Webber et al., 2013, Fischer et al., 2012, Holmqvist et al., 2012, Kvon et al., 2012, Spokony and White, 2012.11.14, Stinchfield et al., 2012, Takaesu et al., 2012, Harris and Ashe, 2011, Li et al., 2011, Oh and Irvine, 2011, Quijano et al., 2011, Toku et al., 2011, Ball et al., 2010, Blanco et al., 2010, Chen and Xu, 2010, Dworkin et al., 2009, Lembong et al., 2009, Liu et al., 2009, Casas-Tinto et al., 2008, Christoforou et al., 2008, Miles et al., 2008, Ng, 2008, Pinto et al., 2008, Yakoby et al., 2008, Yao et al., 2008, Beltran et al., 2007, Gao and Laughon, 2007, Li et al., 2007, Shravage et al., 2007, Walsh and Carroll, 2007, Wang et al., 2007, Bangi and Wharton, 2006, Bernardi et al., 2006, Davidson and Erwin, 2006, Gao and Laughon, 2006, Molnar et al., 2006, Sotillos and de Celis, 2006, Takaesu et al., 2006, Yao et al., 2006, Gao et al., 2005, Kirilly et al., 2005, Marques, 2005, Xie et al., 2005, Yamashita et al., 2005, Pyrowolakis et al., 2004, Gim et al., 2001, Kyoda et al., 2000, Pickeral et al., 2000)
anon-EST:Posey121
l(3)SG36
l(3)XIIm137
Name Synonyms
lethal(3)SG36
lethal(3)SG70
Secondary FlyBase IDs
  • FBgn0002479
  • FBgn0002509
  • FBgn0013946
  • FBgn0027760
Datasets (2)
Study focus (2)
Experimental Role
Project
Project Type
Title
  • bait_protein
ChIP characterization of transcription factor genome binding, Berkeley Drosophila Transcription Factor Network Project.
  • bait_protein
Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
References (385)