• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Pms2

General Information
Symbol	Dmel\Pms2	Species	D. melanogaster
Name	Pms2	Annotation symbol	CG8169
Feature type	protein_coding_gene	FlyBase ID	FBgn0011660
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51F11-51F11	Sequence location	2R:11,255,579..11,259,025 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pms2 is referred to in FlyBase by the symbol Dmel\Pms2 (CG8169, FBgn0011660). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: mismatched DNA binding; ATP binding. Based on sequence similarity, it is predicted to be involved in the biological process: mismatch repair. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA mismatch repair protein; DNA mismatch repair protein Pms1/Mlh2; DNA mismatch repair protein, C-terminal; DNA mismatch repair protein, N-terminal; DNA mismatch repair, conserved site; Histidine kinase-like ATPase, ATP-binding domain; MutL, C-terminal, dimerisation; Ribosomal protein S5 domain 2-type fold; Ribosomal protein S5 domain 2-type fold, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1641382_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Pms2. Gene sequence location is 2R:11255579..11259025.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms MutSalpha complex binding single-stranded DNA binding reciprocal meiotic recombination mismatch repair complex ATPase activity
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51F11-51F11   Limits computationally determined from genome sequence between P{PZ}scb01288 and P{lacW}dupk03308
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51F-51F     (McKee, 1998.5.27)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pms2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pms2-RA FBtr0087388  NM_057675   3040   899
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pms2-PA   FBpp0086520   101.3   899   5.20     NP_477023   AAF58142
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA mismatch repair protein (IPR002099) Histidine kinase-like ATPase, ATP-binding domain (IPR003594) DNA mismatch repair protein, C-terminal (IPR013507) Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721) DNA mismatch repair, conserved site (IPR014762) DNA mismatch repair protein, N-terminal (IPR014763) MutL, C-terminal, dimerisation (IPR014790) DNA mismatch repair protein Pms1/Mlh2 (IPR015434) Ribosomal protein S5 domain 2-type fold (IPR020568)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201705   AA941378   AE013599 AAF58142   AC008343   AF068271 AAC19245   AI292490   AI456947   AI518690   AI541940   AI543280   AW944534   AY069833 AAL39978   BF486455   BF490334   BF498846   BF504160   BF506174   BG637814   BI241932   BI368355   CO183417   CO188031   CO337411   EC202298   EC266114   EV577278   EV581192   EY198982   GH867189
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZA03 Q8T9C0 O76417
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    85.85 Larval Midgut    16.5 Larval Hindgut    23.5 Larval Malpighian Tubules    28 Larval Fat Body    41.7 Larval Salivary Gland    24.3 Larval Trachea    44.75 Larval Carcass    34.3 Adult Head    20.6 Adult Eye    18.475 Adult Brain    42.5 Adult Thoracic-Abdominal Ganglion    57.8 Adult Crop    15.8 Adult Midgut    16.9 Adult Hindgut    13.9 Adult Malpighian Tubules    13.2 Adult Fat Body    6.4 Adult Salivary Gland    9.4 Adult Heart    6.3 Adult VirginFemale Spermatheca    8.9 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    163.1 Adult Testis    125.2 Adult Male Accessory Gland    28 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    42.5   85.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    57.8   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    6.4   no informative data  Salivary Gland    9.4   NA  Heart    6.3   44.75  Trachea    NA   NA  VirginFemale Spermatheca    8.9   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    163.1   NA  Testis    125.2   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    37 ovary, mated 4-day female    35 testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female  (37) ovary, mated 4-day female  (35) testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    37 ovary, mated 4-day female    35 testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    37 ovary, mated 4-day female    35 testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    37 ovary, mated 4-day female    35 testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female  (37) ovary, mated 4-day female  (35) testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    37 ovary, mated 4-day female    35 testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    6 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    2 carcass, larvae L3 wandering    5 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    37 ovary, mated 4-day female    35 testis, mated 4-day male    16 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    11 embryo 04-06hr    10 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    4 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    15 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167    35 embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167  (35) embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2  26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167    35 embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167    35 embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167    35 embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167  (35) embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2  26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167    35 embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    13 embryonic 1182-4H    9 embryonic GM2    15 embryonic Kc167    35 embryonic S1    11 embryonic S3    17 leg disc CME L1    18 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    10 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    12 ovary fGS/OSS    16 ovary OSC    18 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011660 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8169-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Pms2GD14607 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Pms2 Class Mutagen Stocks Known lesion Pms2MI06364 1 -- Pms2EP2331 P-element activity 0 Yes Pms2f03177 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pms2 Class Mutagen Stocks Known lesion Pms2GD14607 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pms2KK102337 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pms2NIG.8169R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14607} NA P{KK102337} NA P{NIG.8169R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Pms2MI06364 NA P{GT1}BG01492 NA PBac{WH}Pms2f03177 NA insertion of mobile activating element P{EP}Pms2EP2331 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from biological aspect of ancestor with PANTHER:PTN000008161 (assigned by RefGenome) (Gaudet et al., 2010) ATP binding inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR003594, InterPro:IPR013507, InterPro:IPR014790 (FlyBase Curators et al., 2004-) mismatched DNA binding inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR013507 (FlyBase Curators et al., 2004-) MutSalpha complex binding inferred from biological aspect of ancestor with PANTHER:PTN000008163 (assigned by RefGenome) (Gaudet et al., 2010) single-stranded DNA binding inferred from biological aspect of ancestor with PANTHER:PTN000008161 (assigned by RefGenome) (Gaudet et al., 2010)
Biological Process
CV term Evidence References
mismatch repair inferred from biological aspect of ancestor with PANTHER:PTN000008161 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity (McKee, 1994) inferred from sequence or structural similarity with mouse Pms2 (FlyBase, 1992-) reciprocal meiotic recombination inferred from biological aspect of ancestor with PANTHER:PTN000008163 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component
CV term Evidence References
mismatch repair complex inferred from biological aspect of ancestor with PANTHER:PTN000008161 (assigned by RefGenome) (Gaudet et al., 2010) MutLalpha complex inferred from biological aspect of ancestor with PANTHER:PTN000008284 (assigned by RefGenome) (Gaudet et al., 2010)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pms2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62441 DroID - A comprehensive database of gene and protein interactions. • FBgn0011660 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36705
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N8RQ6 Dipteran inclusive ortholog search EOG6H72KP Insect inclusive ortholog search EOG65X6R4 Arthropod inclusive ortholog search EOG6VMCWC Metazoa inclusive ortholog search EOG65BD7F
Orthologs in Drosophila Species (EOG6N8RQ6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pms2     Drosophila simulans   Dsim\GD25619 Y   Drosophila sechellia   Dsec\GM20141 Y   Drosophila erecta   Dere\GG22356 Y   Drosophila yakuba   Dyak\GE14157 Y   Drosophila ananassae   Dana\GF11871 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20862 Y   Drosophila persimilis   Dper\GL20044 Y   Drosophila willistoni   Dwil\GK23208 Y   Drosophila virilis   Dvir\GJ19872 Y   Drosophila mojavensis   Dmoj\GI20104 Y   Drosophila grimshawi   Dgri\GH21651 Y
Orthologs in non-Drosophila Dipterans (EOG6H72KP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010033   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013690   Anopheles gambiae Malaria mosquito  Agam\AGAP007126   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016932
Orthologs in non-Dipteran Insects (EOG65X6R4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55893   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012340   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14065   Atta cephalotes Leafcutter ant  Acep\ACEP13308   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22899   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22137   Linepithema humile Argentine ant  Lhum\LH11385   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12383   Solenopsis invicta Red fire ant  Sinv\SINV24297   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005502   Acyrthosiphon pisum Pea aphid  Apim\ACYPI065830   Bombyx mori Silkmoth  Bmor\BGIBMGA012027   Pediculus humanus Human body louse  Phum\PHUM182300   Tribolium castaneum Red flour beetle  Tcas\TC002932
Orthologs in non-Insect Arthropods (EOG6VMCWC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Exd1   Ixodes scapularis Deer tick  Isca\ISCW016226
Orthologs in non-Arthropod Metazoa (EOG65BD7F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pms-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027975gn   Danio rerio Zebrafish  Drer\pms2   Xenopus tropicalis Western clawed frog  Xtro\pms2   Gallus gallus Domestic chicken  Ggal\PMS2   Mus musculus House mouse  Mmus\Pms2   Rattus norvegicus Norway rat  Rnor\Pms2   Homo sapiens Human  Hsap\PMS2
Human Orthologs (1)
Gene OMIM HGNC Hsap\PMS2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25619 Drosophila sechellia Dsec\GM20141 Drosophila erecta Dere\GG22356 Drosophila yakuba Dyak\GE14157 Drosophila ananassae Dana\GF11871 Drosophila pseudoobscura pseudoobscura Dpse\GA20862 Drosophila persimilis Dper\GL20044 Drosophila willistoni Dwil\GK23208 Drosophila virilis Dvir\GJ19872 Drosophila mojavensis Dmoj\GI20104 Drosophila grimshawi Dgri\GH21651
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	43057 y1 w*; Mi{MIC}Pms2MI06364
VDRC	v108638 P{KK102337}VIE-260B v39193 w1118; P{GD14607}v39193/CyO
Genomic Clones ( 2 )
	BACR03D24 BACR33K06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD07911
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05471 AT08575 AT13403 AT20756 AT26675 GH15410 LD25501 LD37124 LD38367 RE39138 RE54311 SD09988
Other clones	102431 569077 Dmel_dig_002545_0690_2185 Dmel_dig_006191_0585_2060 EC25695 EK036303 EN14513 LD04909 RP003225854
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011660 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36705
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Mlh1 and Pms2 are involved in the mismatch repair system by which DNA replication errors can be repaired and correcting mismatches in heteroduplex DNAs formed during recombination. (Bradberry et al., 1995) Mlh1 and Pms2 are members of a family of genes that encode proteins needed for repair of mismatches generated either during DNA replication or during recombination. (McKee, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057675 RefSeq (Proteins) • NP_477023 DDBJ / EMBL / GenBank • AAC19245 AAF58142 AAL39978 AC008343 AF068271 AI541940 AW944534 AY069833 Entrez Gene - A searchable database of RefSeq genes. • 36705 UniProtKB/TrEMBL • A1ZA03 O76417 Q8T9C0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA mismatch repair protein (IPR002099) Histidine kinase-like ATPase, ATP-binding domain (IPR003594) DNA mismatch repair protein, C-terminal (IPR013507) Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721) DNA mismatch repair, conserved site (IPR014762) DNA mismatch repair protein, N-terminal (IPR014763) MutL, C-terminal, dimerisation (IPR014790) DNA mismatch repair protein Pms1/Mlh2 (IPR015434) Ribosomal protein S5 domain 2-type fold (IPR020568)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62441 DroID - A comprehensive database of gene and protein interactions. • FBgn0011660 DRSC - Results from RNAi screens. • FBgn0011660 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011660 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8169-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011660 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36705 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36705 modMine - Data generated by the modENCODE project. • FBgn0011660
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG8169 (Keleman et al., 2009.8.5, Hughes et al., 2008) dmlh2 (Bradberry et al., 1995, ) dmlh-2 (McKee, 1994) dpms2   Mlh2   pms2 (Orian et al., 2003) Pms2 (Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Pms2
Secondary FlyBase IDs
	FBgn0024325
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Show all research papers ...