• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Moe

General Information
Symbol	Dmel\Moe	Species	D. melanogaster
Name	Moesin	Annotation symbol	CG10701
Feature type	protein_coding_gene	FlyBase ID	FBgn0011661
Gene Model Status	Current	Stock availability	45 publicly available
Also Known As	Dmoe, l(1)G0067
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	8B4-8B6	Sequence location	X:8,767,045..8,792,365 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Moesin is referred to in FlyBase by the symbol Dmel\Moe (CG10701, FBgn0011661). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; phosphatidylinositol-4,5-bisphosphate binding. There is experimental evidence that it is involved in the biological process: determination of left/right symmetry; olfactory behavior; oocyte anterior/posterior axis specification; actin cytoskeleton organization; establishment or maintenance of epithelial cell apical/basal polarity; establishment or maintenance of polarity of larval imaginal disc epithelium; rhabdomere membrane biogenesis; rhabdomere development; regulation of actin cytoskeleton organization; regulation of membrane potential in photoreceptor cell. 105 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; thoracic segment; external compound sense organ; non-connected developing system; imaginal precursor; dorsal trunk primordium; organelle; embryonic hindgut; embryonic foregut. It has 13 annotated transcripts and 13 annotated polypeptides. Protein features are: Band 4.1 domain; Band 4.1 family; Ezrin/radixin/moesin; Ezrin/radixin/moesin like; Ezrin/radixin/moesin, C-terminal; FERM central domain; FERM conserved site; FERM domain; FERM, C-terminal PH-like domain; FERM, N-terminal; FERM/acyl-CoA-binding protein, 3-helical bundle; Moesin; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1633074_a_at completely aligns to an exonic region common to each of the 10 FlyBase-annotated transcript isoforms of Moe. Gene sequence location is X:8767045..8792365.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles Moe[003] Controlled Vocabulary Terms male courtship behavior, veined wing generated song production
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8B4-8B6   (determined by in situ hybridisation); Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
Experimentally Determined Cytological Location
Cytogenetic map Notes References 8B4-8B4   (determined by in situ hybridisation)   (Molnar et al., 2006) 8B1-8B4   (determined by in situ hybridisation) 8B3--7 (determined by in situ hybridisation)   (Peter et al., 2002) 8B-8B     (Edwards, 1994.3.30) 8B1-8B4   (determined by in situ hybridisation) 8B3--7 (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 8B1-8B4   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 8E3-8E4   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29) 8B-8C     (Akaboshi and Inoue, 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Moe for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts do not represent all supported alternative splices within 5' UTR.Ó "Annotated transcripts do not represent all supported alternative splices within 5' UTR.Ó Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Moe-RA FBtr0071271  NM_167169   2353   640 Moe-RB FBtr0071270  NM_167168   2468   649 Moe-RC FBtr0071272  NM_167170   2027   512 Moe-RD FBtr0071269  NM_080343   3003   575 Moe-RE FBtr0071273  NM_206669   2283   575 Moe-RF FBtr0071274  NM_206668   2919   575 Moe-RG FBtr0071275  NM_206667   2295   575 Moe-RH FBtr0071276  NM_206666   2236   575 Moe-RI FBtr0071277  NM_206665   2282   575 Moe-RJ FBtr0071278  NM_206664   2401   578 Moe-RK FBtr0308193  NM_001258654   3064   646 Moe-RL FBtr0308194  NM_001258655   2528   578 Moe-RM FBtr0331601  NM_001272432   2995   584
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Moe-PA   FBpp0071214   75.3   640   5.48     NP_727291   AAF46417 Moe-PB   FBpp0071213   76.2   649   6.02     NP_727290   AAF46416 Moe-PC   FBpp0071215   60.6   512   5.53     NP_727292   AAF46418 Moe-PD   FBpp0071212   67.9   575   5.78     NP_525082   AAF46415 Moe-PE   FBpp0089231   67.9   575   5.78     NP_996392   AAS65294 Moe-PF   FBpp0089232   67.9   575   5.78     NP_996391   AAS65295 Moe-PG   FBpp0089233   67.9   575   5.78     NP_996390   AAS65296 Moe-PH   FBpp0089234   67.9   575   5.78     NP_996389   AAS65297 Moe-PI   FBpp0089235   67.9   575   5.78     NP_996388   AAS65298 Moe-PJ   FBpp0089236   68.1   578   5.78     NP_996387   AAS65299 Moe-PK   FBpp0300513   75.9   646   6.02     NP_001245583   AFH07297 Moe-PL   FBpp0300514   68.1   578   5.78     NP_001245584   AFH07298 Moe-PM   FBpp0303991   68.9   584   5.78     NP_001259361   AGB95204
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Ezrin/radixin/moesin like (IPR000798) Moesin (IPR008954) Ezrin/radixin/moesin (IPR011174) Ezrin/radixin/moesin, C-terminal (IPR011259) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) FERM, N-terminal (IPR018979) FERM, C-terminal PH-like domain (IPR018980) FERM conserved site (IPR019747) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263991   AA567446   AA695407   AA695450   AA696077   AA696638   AA802831   AA803709   AA820266   AA821041   AA949399   AA949771   AE014298 AAF46415   AE014298 AAF46416   AE014298 AAF46417   AE014298 AAF46418   AE014298 AAS65294   AE014298 AAS65295   AE014298 AAS65296   AE014298 AAS65297   AE014298 AAS65298   AE014298 AAS65299   AE014298 AFH07297   AE014298 AFH07298   AE014298 AGB95204   AI106804   AI107055   AI239075   AI258597   AI258649   AI259765   AI260089   AI261157   AI293051   AI293060   AI293065   AI293777   AI296348   AI296733   AI387627   AI403142   AI404577   AI404814   AI404832   AI405295   AI456513   AI516266   AI516480   AI520004   AI530763   AI531732   AI532711   AI533322   AI533740   AI533835   AI533889   AI534003   AI534708   AI541869   AI542198   AI543570   AI543928   AI543972   AI546725   AQ025424   AQ254784   AW944629   AX777301   AX777303   AX777305   AX777307   AY069855 AAL40000   BE975103   BF492211   BF499980   BF505856   BG632644   BG637392   BG640551   BH011525   BI161886   BI161887   BI162801   BI162959   BI164480   BI165313   BI167210   BI167391   BI168665   BI168727   BI169657   BI169748   BI170865   BI171518   BI172956   BI173058   BI213241   BI216295   BI227685   BI228581   BI228920   BI229144   BI229765   BI230793   BI231129   BI232899   BI234022   BI234481   BI234557   BI235005   BI235247   BI236133   BI236402   BI237386   BI241915   BI242015   BI242402   BI243110   BI243360   BI243370   BI352529   BI353060   BI354749   BI356438   BI356955   BI356970   BI357495   BI357785   BI358287   BI362821   BI367158   BI367468   BI367673   BI367775   BI369274   BI370400   BI373040   BI375414   BI375658   BI375839   BI482027   BI483085   BI483686   BI484781   BI484859   BI484884   BI485359   BI486839   BI563534   BI565737   BI575612   BI575967   BI576501   BI577523   BI579749   BI580327   BI580611   BI580865   BI588070   BI612225   BI613173   BI614340   BI618179   BI626622   BI632397   BI633678   BI637945   BI638075   BI638716   BI639386   BI640168   BI641041   BP543747   BP543748   BP550940   BP550941   BP553108   BP553109   BP558667   BQ102674   BQ102905   BQ103156   BQ103417   BQ103558   BT099729   BT099936   BT120336   BT120337   CK604224   CK604225   CK657301   CK657469   CK658417   CK659307   CK659551   CK659820   CK660247   CK662363   CO152671   CO152764   CO153102   CO153181   CO153184   CO153193   CO153214   CO153570   CO154067   CO154257   CO154346   CO154571   CO154621   CO154961   CO155001   CO155060   CO155108   CO155112   CO155266   CO155538   CO155681   CO155760   CO155804   CO155953   CO156363   CO156365   CO156513   CO156546   CO156718   CO156785   CO156959   CO156996   CO157037   CO157051   CO185627   CO186697   CO187709   CO266315   CO274498   CO275799   CO282436   CO283625   CO290583   CO296876   CO298145   CO308979   CO316197   CO321741   CO328621   CO329355   CO332719   CO335521   CO335561   CO335856   CO335943   CO336066   CO336177   CO336230   CO336303   CO336326   CO336859   CO336877   CO336932   CO336975   CO337055   CO337206   CO337230   CO337317   CO337460   CO337611   CO337752   CO337811   CO337935   CO338069   CO338175   CO338197   CO338292   CO338319   CO338878   CO339576   CZ472093   CZ472094   EC060627   EC066316   EC068886   EC072526   EC073551   EC082021   EC090665   EC194548   EC198579   EC200869   EC204733   EC205313   EC208885   EC213175   EC221906   EC222154   EC227781   EC230846   EC242651   EC260876   EC261236   EC261249   EC261274   EC261527   EC261528   EC261591   EC261615   EC261716   EC261995   EC262028   EC262070   EC262273   EC262322   EC262422   EC262811   EC262957   EC262972   EC263031   EC263316   EC263335   EC263464   EC263469   EC263485   EC264005   EC264026   EC264147   EC264326   EC264503   EC264928   EC264934   EC265597   EC265630   EC265634   EC265865   EC265901   EC265950   EC265981   EC266042   EC266214   EC266324   EC266325   EC266768   EC266800   EC266856   EC267018   EC267194   EC267604   EC267865   EC267925   EC267942   EV576856   EV594291   EV596424   EV596989   EV597415   EV597519   EV600798   GH941221   GH941783   GH942876   GH943262   GH943621   GH944027   GH944411   GH944623   GH944856   GH945017   GH945247   GH945445   GH945484   GH946328   GH946661   GH947297   GH947448   GH947543   GH947900   GH949699   GH950366   GH951356   GH951576   GH951663   GH951863   GH952665   GH954336   GH954351   GH954933   GH955143   GH956015   GH956045   GH957605   GH958247   GH958352   GH959003   GH959624   GH960218   GH960828   GH961008   GH961131   GH961911   GH962297   GH962499   GH963011   GH964156   GH964249   GH964334   GH966146   GH966570   GH967049   GH969658   GH969827   GH970006   GH970894   GH970899   GH971207   GH971355   GH971614   GH973291   GH973782   GH974276   GH974292   GH974365   GH974676   GH974721   GH975558   GH976055   GH978020   GH978232   GH978467   GH978914   GH979029   GH979398   GH979667   GH980909   GH981957   GH981964   GH982761   GH984761   GH984886   GH985064   L38909 AAB48934   U08218 AAA19857   U23798 AAA65059
UniProtKB/Swiss-Prot	P46150
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage proventriculus primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic anal pad   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic dorsal apodeme   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic small intestine   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval dorsal trunk   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference pupal stage   mesothoracic bristle   • actin cytoskeleton (Guild et al., 2002) immunolocalization Stage Tissue/Position (including subcellular localization) Reference pharate adult stage   rhabdomere   (Karagiosis and Ready, 2004) adult stage   rhabdomere   (Karagiosis and Ready, 2004)
Additional Descriptive Data
	Moe protein localizes to the base of the rhabdomere, and is seen in this location from about 50% through pupal development. (Karagiosis and Ready, 2004) Use of a Moe-GFPfusion construct was used as a marker of actin bundles in 32-56 hour developing pupal bristles in the thorax. (Guild et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with actin cytoskeleton inferred from direct assay (Roch et al., 2010) colocalizes_with actin filament inferred from direct assay (Vilmos et al., 2009) cell cortex inferred from direct assay (Vilmos et al., 2009, Roch et al., 2010) cytoplasm inferred from direct assay (Vilmos et al., 2009) colocalizes_with cytoplasm inferred from direct assay (Roch et al., 2010) NOT fusome inferred from direct assay (de Cuevas et al., 1996) nucleus inferred from direct assay (Vilmos et al., 2009) colocalizes_with nucleus inferred from direct assay (Roch et al., 2010) plasma membrane inferred from direct assay (McCartney and Fehon, 1996, de Cuevas et al., 1996, Verdier et al., 2006) colocalizes_with spindle inferred from direct assay (Vilmos et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1295.225 Larval Midgut    2647.3 Larval Hindgut    2839.6 Larval Malpighian Tubules    2534 Larval Fat Body    833.9 Larval Salivary Gland    4284.5 Larval Trachea    3858.35 Larval Carcass    1758 Adult Head    1583.1 Adult Eye    4454.4 Adult Brain    987.6 Adult Thoracic-Abdominal Ganglion    1238.5 Adult Crop    2455.8 Adult Midgut    2033.6 Adult Hindgut    2291.9 Adult Malpighian Tubules    2299.6 Adult Fat Body    640.2 Adult Salivary Gland    3377.9 Adult Heart    1424.675 Adult VirginFemale Spermatheca    1131.7 Adult InseminatedFemale Spermatheca    1321.3 Adult Ovary    1176.1 Adult Testis    260.5 Adult Male Accessory Gland    2573.8 Adult Carcass    954.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1295.225) Larval Midgut  (2647.3) Larval Hindgut  (2839.6) Larval Malpighian Tubules  (2534) Larval Fat Body  (833.9) Larval Salivary Gland  (4284.5) Larval Trachea  (3858.35) Larval Carcass  (1758) Adult Head  (1583.1) Adult Eye  (4454.4) Adult Brain  (987.6) Adult Thoracic-Abdominal Ganglion  (1238.5) Adult Crop  (2455.8) Adult Midgut  (2033.6) Adult Hindgut  (2291.9) Adult Malpighian Tubules  (2299.6) Adult Fat Body  (640.2) Adult Salivary Gland  (3377.9) Adult Heart  (1424.675) Adult VirginFemale Spermatheca  (1131.7) Adult InseminatedFemale Spermatheca  (1321.3) Adult Ovary  (1176.1) Adult Testis    260.5 Adult Male Accessory Gland  (2573.8) Adult Carcass  (954.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1295.225) Larval Midgut  (2647.3) Larval Hindgut  (2839.6) Larval Malpighian Tubules  (2534) Larval Fat Body    833.9 Larval Salivary Gland  (4284.5) Larval Trachea  (3858.35) Larval Carcass  (1758) Adult Head  (1583.1) Adult Eye  (4454.4) Adult Brain    987.6 Adult Thoracic-Abdominal Ganglion  (1238.5) Adult Crop  (2455.8) Adult Midgut  (2033.6) Adult Hindgut  (2291.9) Adult Malpighian Tubules  (2299.6) Adult Fat Body    640.2 Adult Salivary Gland  (3377.9) Adult Heart  (1424.675) Adult VirginFemale Spermatheca  (1131.7) Adult InseminatedFemale Spermatheca  (1321.3) Adult Ovary  (1176.1) Adult Testis    260.5 Adult Male Accessory Gland  (2573.8) Adult Carcass    954.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1295.225 Larval Midgut    2647.3 Larval Hindgut    2839.6 Larval Malpighian Tubules    2534 Larval Fat Body    833.9 Larval Salivary Gland    4284.5 Larval Trachea    3858.35 Larval Carcass    1758 Adult Head    1583.1 Adult Eye    4454.4 Adult Brain    987.6 Adult Thoracic-Abdominal Ganglion    1238.5 Adult Crop    2455.8 Adult Midgut    2033.6 Adult Hindgut    2291.9 Adult Malpighian Tubules    2299.6 Adult Fat Body    640.2 Adult Salivary Gland    3377.9 Adult Heart    1424.675 Adult VirginFemale Spermatheca    1131.7 Adult InseminatedFemale Spermatheca    1321.3 Adult Ovary    1176.1 Adult Testis    260.5 Adult Male Accessory Gland    2573.8 Adult Carcass    954.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1295.225 Larval Midgut    2647.3 Larval Hindgut    2839.6 Larval Malpighian Tubules    2534 Larval Fat Body    833.9 Larval Salivary Gland    4284.5 Larval Trachea    3858.35 Larval Carcass    1758 Adult Head    1583.1 Adult Eye    4454.4 Adult Brain    987.6 Adult Thoracic-Abdominal Ganglion    1238.5 Adult Crop    2455.8 Adult Midgut    2033.6 Adult Hindgut    2291.9 Adult Malpighian Tubules    2299.6 Adult Fat Body    640.2 Adult Salivary Gland    3377.9 Adult Heart    1424.675 Adult VirginFemale Spermatheca    1131.7 Adult InseminatedFemale Spermatheca    1321.3 Adult Ovary    1176.1 Adult Testis    260.5 Adult Male Accessory Gland    2573.8 Adult Carcass    954.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1295.225) Larval Midgut  (2647.3) Larval Hindgut  (2839.6) Larval Malpighian Tubules  (2534) Larval Fat Body  (833.9) Larval Salivary Gland  (4284.5) Larval Trachea  (3858.35) Larval Carcass  (1758) Adult Head  (1583.1) Adult Eye  (4454.4) Adult Brain  (987.6) Adult Thoracic-Abdominal Ganglion  (1238.5) Adult Crop  (2455.8) Adult Midgut  (2033.6) Adult Hindgut  (2291.9) Adult Malpighian Tubules  (2299.6) Adult Fat Body  640.2 Adult Salivary Gland  (3377.9) Adult Heart  (1424.675) Adult VirginFemale Spermatheca  (1131.7) Adult InseminatedFemale Spermatheca  (1321.3) Adult Ovary  (1176.1) Adult Testis    260.5 Adult Male Accessory Gland  (2573.8) Adult Carcass  (954.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1295.225 Larval Midgut  (2647.3) Larval Hindgut  (2839.6) Larval Malpighian Tubules  (2534) Larval Fat Body    833.9 Larval Salivary Gland  (4284.5) Larval Trachea  (3858.35) Larval Carcass  (1758) Adult Head  1583.1 Adult Eye  (4454.4) Adult Brain    987.6 Adult Thoracic-Abdominal Ganglion  1238.5 Adult Crop  (2455.8) Adult Midgut  (2033.6) Adult Hindgut  (2291.9) Adult Malpighian Tubules  (2299.6) Adult Fat Body    640.2 Adult Salivary Gland  (3377.9) Adult Heart  1424.675 Adult VirginFemale Spermatheca  1131.7 Adult InseminatedFemale Spermatheca  1321.3 Adult Ovary  1176.1 Adult Testis    260.5 Adult Male Accessory Gland  (2573.8) Adult Carcass    954.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1295.225 Larval Midgut    2647.3 Larval Hindgut    2839.6 Larval Malpighian Tubules    2534 Larval Fat Body    833.9 Larval Salivary Gland    4284.5 Larval Trachea    3858.35 Larval Carcass    1758 Adult Head    1583.1 Adult Eye    4454.4 Adult Brain    987.6 Adult Thoracic-Abdominal Ganglion    1238.5 Adult Crop    2455.8 Adult Midgut    2033.6 Adult Hindgut    2291.9 Adult Malpighian Tubules    2299.6 Adult Fat Body    640.2 Adult Salivary Gland    3377.9 Adult Heart    1424.675 Adult VirginFemale Spermatheca    1131.7 Adult InseminatedFemale Spermatheca    1321.3 Adult Ovary    1176.1 Adult Testis    260.5 Adult Male Accessory Gland    2573.8 Adult Carcass    954.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1583.1   NA  Eye    4454.4   NA  Brain    987.6   1295.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1238.5   NA  Crop    2455.8   2647.3  Midgut    2033.6   2839.6  Hindgut    2291.9   2534  Malpighian Tubules    2299.6   833.9  Fat Body    640.2   4284.5  Salivary Gland    3377.9   NA  Heart    1424.675   3858.35  Trachea    NA   NA  VirginFemale Spermatheca    1131.7   NA  InseminatedFemale Spermatheca    1321.3   NA  Ovary    1176.1   NA  Testis    260.5   NA  Male Accessory Gland    2573.8   1758  Carcass    954.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    147 central nervous system, larvae L3    148 central nervous system, pupae P8    71 head, virgin 1-day female    91 head, virgin 4-day female    89 head, virgin 20-day female    66 head, mated 1-day female    88 head, mated 4-day female    87 head, mated 20-day female    63 head, mated 1-day male    138 head, mated 4-day male    130 head, mated 20-day male    135 salivary gland, larvae L3 wandering    81 salivary gland, white prepupae    276 digestive system, larvae L3 wandering    112 digestive system, 1-day adult    107 digestive system, 4-day adult    117 digestive system, 20-day adult    116 fat body, larvae L3 wandering    30 fat body, white prepupae    35 fat body, pupae P8    86 carcass, larvae L3 wandering    183 carcass, 1-day adult    56 carcass, 4-day adult    60 carcass, 20-day adult    65 ovary, virgin 4-day female    137 ovary, mated 4-day female    131 testis, mated 4-day male    24 accessory gland, mated 4-day male    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (147) central nervous system, larvae L3  (148) central nervous system, pupae P8  (71) head, virgin 1-day female  (91) head, virgin 4-day female  (89) head, virgin 20-day female  (66) head, mated 1-day female  (88) head, mated 4-day female  (87) head, mated 20-day female  (63) head, mated 1-day male  (138) head, mated 4-day male  (130) head, mated 20-day male  (135) salivary gland, larvae L3 wandering  (81) salivary gland, white prepupae  (276) digestive system, larvae L3 wandering  (112) digestive system, 1-day adult  (107) digestive system, 4-day adult  (117) digestive system, 20-day adult  (116) fat body, larvae L3 wandering  (30) fat body, white prepupae  (35) fat body, pupae P8  (86) carcass, larvae L3 wandering  (183) carcass, 1-day adult  (56) carcass, 4-day adult  (60) carcass, 20-day adult  (65) ovary, virgin 4-day female  (137) ovary, mated 4-day female  (131) testis, mated 4-day male    24 accessory gland, mated 4-day male  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (147) central nervous system, larvae L3  (148) central nervous system, pupae P8    71 head, virgin 1-day female    91 head, virgin 4-day female    89 head, virgin 20-day female    66 head, mated 1-day female    88 head, mated 4-day female    87 head, mated 20-day female    63 head, mated 1-day male  (138) head, mated 4-day male  (130) head, mated 20-day male  (135) salivary gland, larvae L3 wandering    81 salivary gland, white prepupae  (276) digestive system, larvae L3 wandering  (112) digestive system, 1-day adult  107 digestive system, 4-day adult  (117) digestive system, 20-day adult  (116) fat body, larvae L3 wandering    30 fat body, white prepupae    35 fat body, pupae P8    86 carcass, larvae L3 wandering  (183) carcass, 1-day adult    56 carcass, 4-day adult    60 carcass, 20-day adult    65 ovary, virgin 4-day female  (137) ovary, mated 4-day female  (131) testis, mated 4-day male    24 accessory gland, mated 4-day male    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    147 central nervous system, larvae L3    148 central nervous system, pupae P8    71 head, virgin 1-day female    91 head, virgin 4-day female    89 head, virgin 20-day female    66 head, mated 1-day female    88 head, mated 4-day female    87 head, mated 20-day female    63 head, mated 1-day male    138 head, mated 4-day male    130 head, mated 20-day male    135 salivary gland, larvae L3 wandering    81 salivary gland, white prepupae    276 digestive system, larvae L3 wandering    112 digestive system, 1-day adult    107 digestive system, 4-day adult    117 digestive system, 20-day adult    116 fat body, larvae L3 wandering    30 fat body, white prepupae    35 fat body, pupae P8    86 carcass, larvae L3 wandering    183 carcass, 1-day adult    56 carcass, 4-day adult    60 carcass, 20-day adult    65 ovary, virgin 4-day female    137 ovary, mated 4-day female    131 testis, mated 4-day male    24 accessory gland, mated 4-day male    70 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    147 central nervous system, larvae L3    148 central nervous system, pupae P8    71 head, virgin 1-day female    91 head, virgin 4-day female    89 head, virgin 20-day female    66 head, mated 1-day female    88 head, mated 4-day female    87 head, mated 20-day female    63 head, mated 1-day male    138 head, mated 4-day male    130 head, mated 20-day male    135 salivary gland, larvae L3 wandering    81 salivary gland, white prepupae    276 digestive system, larvae L3 wandering    112 digestive system, 1-day adult    107 digestive system, 4-day adult    117 digestive system, 20-day adult    116 fat body, larvae L3 wandering    30 fat body, white prepupae    35 fat body, pupae P8    86 carcass, larvae L3 wandering    183 carcass, 1-day adult    56 carcass, 4-day adult    60 carcass, 20-day adult    65 ovary, virgin 4-day female    137 ovary, mated 4-day female    131 testis, mated 4-day male    24 accessory gland, mated 4-day male    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (147) central nervous system, larvae L3  (148) central nervous system, pupae P8  (71) head, virgin 1-day female  (91) head, virgin 4-day female  (89) head, virgin 20-day female  (66) head, mated 1-day female  (88) head, mated 4-day female  (87) head, mated 20-day female  (63) head, mated 1-day male  (138) head, mated 4-day male  (130) head, mated 20-day male  (135) salivary gland, larvae L3 wandering  (81) salivary gland, white prepupae  (276) digestive system, larvae L3 wandering  (112) digestive system, 1-day adult  (107) digestive system, 4-day adult  (117) digestive system, 20-day adult  (116) fat body, larvae L3 wandering  30 fat body, white prepupae  (35) fat body, pupae P8  (86) carcass, larvae L3 wandering  (183) carcass, 1-day adult  (56) carcass, 4-day adult  (60) carcass, 20-day adult  (65) ovary, virgin 4-day female  (137) ovary, mated 4-day female  (131) testis, mated 4-day male    24 accessory gland, mated 4-day male  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (147) central nervous system, larvae L3  (148) central nervous system, pupae P8    71 head, virgin 1-day female    91 head, virgin 4-day female    89 head, virgin 20-day female    66 head, mated 1-day female    88 head, mated 4-day female    87 head, mated 20-day female    63 head, mated 1-day male  138 head, mated 4-day male  130 head, mated 20-day male  135 salivary gland, larvae L3 wandering    81 salivary gland, white prepupae  (276) digestive system, larvae L3 wandering  112 digestive system, 1-day adult  107 digestive system, 4-day adult  117 digestive system, 20-day adult  116 fat body, larvae L3 wandering    30 fat body, white prepupae    35 fat body, pupae P8    86 carcass, larvae L3 wandering  (183) carcass, 1-day adult    56 carcass, 4-day adult    60 carcass, 20-day adult    65 ovary, virgin 4-day female  137 ovary, mated 4-day female  131 testis, mated 4-day male    24 accessory gland, mated 4-day male    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    147 central nervous system, larvae L3    148 central nervous system, pupae P8    71 head, virgin 1-day female    91 head, virgin 4-day female    89 head, virgin 20-day female    66 head, mated 1-day female    88 head, mated 4-day female    87 head, mated 20-day female    63 head, mated 1-day male    138 head, mated 4-day male    130 head, mated 20-day male    135 salivary gland, larvae L3 wandering    81 salivary gland, white prepupae    276 digestive system, larvae L3 wandering    112 digestive system, 1-day adult    107 digestive system, 4-day adult    117 digestive system, 20-day adult    116 fat body, larvae L3 wandering    30 fat body, white prepupae    35 fat body, pupae P8    86 carcass, larvae L3 wandering    183 carcass, 1-day adult    56 carcass, 4-day adult    60 carcass, 20-day adult    65 ovary, virgin 4-day female    137 ovary, mated 4-day female    131 testis, mated 4-day male    24 accessory gland, mated 4-day male    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    43 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    45 embryo 10-12hr    70 embryo 12-14hr    72 embryo 14-16hr    101 embryo 16-18hr    109 embryo 18-20hr    125 embryo 20-22hr    126 embryo 22-24hr    120 larva L1    86 larva L2    123 larva L3 12hr old    90 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    103 white prepupae new    84 white prepupae 12hr    99 white prepupae 24hr    67 pupae 2d postWPP    121 pupae 3d postWPP    44 pupae 4d postWPP    98 adult male 01day    58 adult male 05day    60 adult male 30day    65 adult female 01day    89 adult female 05day    108 adult female 30day    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (43) embryo 04-06hr    17 embryo 06-08hr  (28) embryo 08-10hr  (45) embryo 10-12hr  (70) embryo 12-14hr  (72) embryo 14-16hr  (101) embryo 16-18hr  (109) embryo 18-20hr  (125) embryo 20-22hr  (126) embryo 22-24hr  (120) larva L1  (86) larva L2  (123) larva L3 12hr old  (90) larva L3 puffstage 1-2  (70) larva L3 puffstage 3-6  (115) larva L3 puffstage 7-9  (103) white prepupae new  (84) white prepupae 12hr  (99) white prepupae 24hr  (67) pupae 2d postWPP  (121) pupae 3d postWPP  (44) pupae 4d postWPP  (98) adult male 01day  (58) adult male 05day  (60) adult male 30day  (65) adult female 01day  (89) adult female 05day  (108) adult female 30day  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    43 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    45 embryo 10-12hr    70 embryo 12-14hr    72 embryo 14-16hr  101 embryo 16-18hr  (109) embryo 18-20hr  (125) embryo 20-22hr  (126) embryo 22-24hr  (120) larva L1    86 larva L2  (123) larva L3 12hr old    90 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6  (115) larva L3 puffstage 7-9  103 white prepupae new    84 white prepupae 12hr    99 white prepupae 24hr    67 pupae 2d postWPP  (121) pupae 3d postWPP    44 pupae 4d postWPP    98 adult male 01day    58 adult male 05day    60 adult male 30day    65 adult female 01day    89 adult female 05day  (108) adult female 30day  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    43 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    45 embryo 10-12hr    70 embryo 12-14hr    72 embryo 14-16hr    101 embryo 16-18hr    109 embryo 18-20hr    125 embryo 20-22hr    126 embryo 22-24hr    120 larva L1    86 larva L2    123 larva L3 12hr old    90 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    103 white prepupae new    84 white prepupae 12hr    99 white prepupae 24hr    67 pupae 2d postWPP    121 pupae 3d postWPP    44 pupae 4d postWPP    98 adult male 01day    58 adult male 05day    60 adult male 30day    65 adult female 01day    89 adult female 05day    108 adult female 30day    105 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    43 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    45 embryo 10-12hr    70 embryo 12-14hr    72 embryo 14-16hr    101 embryo 16-18hr    109 embryo 18-20hr    125 embryo 20-22hr    126 embryo 22-24hr    120 larva L1    86 larva L2    123 larva L3 12hr old    90 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    103 white prepupae new    84 white prepupae 12hr    99 white prepupae 24hr    67 pupae 2d postWPP    121 pupae 3d postWPP    44 pupae 4d postWPP    98 adult male 01day    58 adult male 05day    60 adult male 30day    65 adult female 01day    89 adult female 05day    108 adult female 30day    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (43) embryo 04-06hr    17 embryo 06-08hr  28 embryo 08-10hr  (45) embryo 10-12hr  (70) embryo 12-14hr  (72) embryo 14-16hr  (101) embryo 16-18hr  (109) embryo 18-20hr  (125) embryo 20-22hr  (126) embryo 22-24hr  (120) larva L1  (86) larva L2  (123) larva L3 12hr old  (90) larva L3 puffstage 1-2  (70) larva L3 puffstage 3-6  (115) larva L3 puffstage 7-9  (103) white prepupae new  (84) white prepupae 12hr  (99) white prepupae 24hr  (67) pupae 2d postWPP  (121) pupae 3d postWPP  (44) pupae 4d postWPP  (98) adult male 01day  (58) adult male 05day  (60) adult male 30day  (65) adult female 01day  (89) adult female 05day  (108) adult female 30day  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    43 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    45 embryo 10-12hr    70 embryo 12-14hr    72 embryo 14-16hr  101 embryo 16-18hr  109 embryo 18-20hr  125 embryo 20-22hr  126 embryo 22-24hr  120 larva L1    86 larva L2  123 larva L3 12hr old    90 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6  115 larva L3 puffstage 7-9  103 white prepupae new    84 white prepupae 12hr    99 white prepupae 24hr    67 pupae 2d postWPP  121 pupae 3d postWPP    44 pupae 4d postWPP    98 adult male 01day    58 adult male 05day    60 adult male 30day    65 adult female 01day    89 adult female 05day  108 adult female 30day  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    43 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    45 embryo 10-12hr    70 embryo 12-14hr    72 embryo 14-16hr    101 embryo 16-18hr    109 embryo 18-20hr    125 embryo 20-22hr    126 embryo 22-24hr    120 larva L1    86 larva L2    123 larva L3 12hr old    90 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    103 white prepupae new    84 white prepupae 12hr    99 white prepupae 24hr    67 pupae 2d postWPP    121 pupae 3d postWPP    44 pupae 4d postWPP    98 adult male 01day    58 adult male 05day    60 adult male 30day    65 adult female 01day    89 adult female 05day    108 adult female 30day    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    553 Schneider line 2 Sg4    379 embryonic 1182-4H    703 embryonic GM2    716 embryonic Kc167    276 embryonic S1    318 embryonic S3    270 leg disc CME L1    571 wing disc CME-W2    329 wing disc ML-DmD8    485 wing disc ML-DmD9    611 wing disc ML-DmD16-c3    299 wing disc ML-DmD21    290 wing disc ML-DmD32    636 haltere disc ML-DmD17-c3    286 eye-antennal disc ML-DmD11    450 antennal disc ML-DmD20-c5    372 mixed discs ML-DmD4-c1    425 CNS ML-DmBG1-c1    358 CNS ML-DmBG2-c2    219 tumorous blood cells mbn2    289 ovary fGS/OSS    340 ovary OSC    154 ovary OSS    152 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (553) Schneider line 2 Sg4  (379) embryonic 1182-4H  (703) embryonic GM2  (716) embryonic Kc167  (276) embryonic S1  (318) embryonic S3  (270) leg disc CME L1  (571) wing disc CME-W2  (329) wing disc ML-DmD8  (485) wing disc ML-DmD9  (611) wing disc ML-DmD16-c3  (299) wing disc ML-DmD21  (290) wing disc ML-DmD32  (636) haltere disc ML-DmD17-c3  (286) eye-antennal disc ML-DmD11  (450) antennal disc ML-DmD20-c5  (372) mixed discs ML-DmD4-c1  (425) CNS ML-DmBG1-c1  (358) CNS ML-DmBG2-c2  (219) tumorous blood cells mbn2  (289) ovary fGS/OSS  (340) ovary OSC  (154) ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (553) Schneider line 2 Sg4  (379) embryonic 1182-4H  (703) embryonic GM2  (716) embryonic Kc167  (276) embryonic S1  (318) embryonic S3  (270) leg disc CME L1  (571) wing disc CME-W2  (329) wing disc ML-DmD8  (485) wing disc ML-DmD9  (611) wing disc ML-DmD16-c3  (299) wing disc ML-DmD21  (290) wing disc ML-DmD32  (636) haltere disc ML-DmD17-c3  (286) eye-antennal disc ML-DmD11  (450) antennal disc ML-DmD20-c5  (372) mixed discs ML-DmD4-c1  (425) CNS ML-DmBG1-c1  (358) CNS ML-DmBG2-c2  (219) tumorous blood cells mbn2  (289) ovary fGS/OSS  (340) ovary OSC  (154) ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    553 Schneider line 2 Sg4    379 embryonic 1182-4H    703 embryonic GM2    716 embryonic Kc167    276 embryonic S1    318 embryonic S3    270 leg disc CME L1    571 wing disc CME-W2    329 wing disc ML-DmD8    485 wing disc ML-DmD9    611 wing disc ML-DmD16-c3    299 wing disc ML-DmD21    290 wing disc ML-DmD32    636 haltere disc ML-DmD17-c3    286 eye-antennal disc ML-DmD11    450 antennal disc ML-DmD20-c5    372 mixed discs ML-DmD4-c1    425 CNS ML-DmBG1-c1    358 CNS ML-DmBG2-c2    219 tumorous blood cells mbn2    289 ovary fGS/OSS    340 ovary OSC    154 ovary OSS    152 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    553 Schneider line 2 Sg4    379 embryonic 1182-4H    703 embryonic GM2    716 embryonic Kc167    276 embryonic S1    318 embryonic S3    270 leg disc CME L1    571 wing disc CME-W2    329 wing disc ML-DmD8    485 wing disc ML-DmD9    611 wing disc ML-DmD16-c3    299 wing disc ML-DmD21    290 wing disc ML-DmD32    636 haltere disc ML-DmD17-c3    286 eye-antennal disc ML-DmD11    450 antennal disc ML-DmD20-c5    372 mixed discs ML-DmD4-c1    425 CNS ML-DmBG1-c1    358 CNS ML-DmBG2-c2    219 tumorous blood cells mbn2    289 ovary fGS/OSS    340 ovary OSC    154 ovary OSS    152 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (553) Schneider line 2 Sg4  (379) embryonic 1182-4H  (703) embryonic GM2  (716) embryonic Kc167  (276) embryonic S1  (318) embryonic S3  (270) leg disc CME L1  (571) wing disc CME-W2  (329) wing disc ML-DmD8  (485) wing disc ML-DmD9  (611) wing disc ML-DmD16-c3  (299) wing disc ML-DmD21  (290) wing disc ML-DmD32  (636) haltere disc ML-DmD17-c3  (286) eye-antennal disc ML-DmD11  (450) antennal disc ML-DmD20-c5  (372) mixed discs ML-DmD4-c1  (425) CNS ML-DmBG1-c1  (358) CNS ML-DmBG2-c2  (219) tumorous blood cells mbn2  (289) ovary fGS/OSS  (340) ovary OSC  (154) ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (553) Schneider line 2 Sg4  (379) embryonic 1182-4H  (703) embryonic GM2  (716) embryonic Kc167  (276) embryonic S1  (318) embryonic S3  (270) leg disc CME L1  (571) wing disc CME-W2  (329) wing disc ML-DmD8  (485) wing disc ML-DmD9  (611) wing disc ML-DmD16-c3  (299) wing disc ML-DmD21  (290) wing disc ML-DmD32  (636) haltere disc ML-DmD17-c3  (286) eye-antennal disc ML-DmD11  (450) antennal disc ML-DmD20-c5  (372) mixed discs ML-DmD4-c1  (425) CNS ML-DmBG1-c1  (358) CNS ML-DmBG2-c2  (219) tumorous blood cells mbn2  (289) ovary fGS/OSS  (340) ovary OSC  (154) ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    553 Schneider line 2 Sg4    379 embryonic 1182-4H    703 embryonic GM2    716 embryonic Kc167    276 embryonic S1    318 embryonic S3    270 leg disc CME L1    571 wing disc CME-W2    329 wing disc ML-DmD8    485 wing disc ML-DmD9    611 wing disc ML-DmD16-c3    299 wing disc ML-DmD21    290 wing disc ML-DmD32    636 haltere disc ML-DmD17-c3    286 eye-antennal disc ML-DmD11    450 antennal disc ML-DmD20-c5    372 mixed discs ML-DmD4-c1    425 CNS ML-DmBG1-c1    358 CNS ML-DmBG2-c2    219 tumorous blood cells mbn2    289 ovary fGS/OSS    340 ovary OSC    154 ovary OSS    152 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    180 cold shock, 4-day adult    152 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    87 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    120 Copper 0.5 mM 12 hrs, larvae L3    245 Copper 15 mM 48 hrs, 4-day adult    90 Zinc 5 mM 12 hrs, larvae L3    194 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    113 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    113 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    103 Rotenone 2 μg 12 hrs, larvae L3    100 Rotenone 8 μg 12 hrs, larvae L3    96 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (180) cold shock, 4-day adult  (152) heat shock, 4-day adult  (107) Cadmium 50 mM 6 hrs, larvae L3  (87) Cadmium 50 mM 12 hrs, larvae L3  (83) Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (120) Copper 0.5 mM 12 hrs, larvae L3  (245) Copper 15 mM 48 hrs, 4-day adult  (90) Zinc 5 mM 12 hrs, larvae L3  (194) Zinc 4.5 mM 48 hrs, 4-day adult  (92) Ethanol 2.5% 3 hrs, larvae L3  (113) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (110) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (88) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (105) Caffeine 25 mg/ml 48 hrs, 4-day adult  (113) Paraquat 5 mM 48 hrs, 4-day adult  (100) Paraquat 10 mM 48 hrs, 4-day adult  (103) Rotenone 2 μg 12 hrs, larvae L3  (100) Rotenone 8 μg 12 hrs, larvae L3  (96) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (180) cold shock, 4-day adult  (152) heat shock, 4-day adult  107 Cadmium 50 mM 6 hrs, larvae L3    87 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (120) Copper 0.5 mM 12 hrs, larvae L3  (245) Copper 15 mM 48 hrs, 4-day adult    90 Zinc 5 mM 12 hrs, larvae L3  (194) Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3  (113) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (110) Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  105 Caffeine 25 mg/ml 48 hrs, 4-day adult  (113) Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult  103 Rotenone 2 μg 12 hrs, larvae L3    100 Rotenone 8 μg 12 hrs, larvae L3    96 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    180 cold shock, 4-day adult    152 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    87 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    120 Copper 0.5 mM 12 hrs, larvae L3    245 Copper 15 mM 48 hrs, 4-day adult    90 Zinc 5 mM 12 hrs, larvae L3    194 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    113 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    113 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    103 Rotenone 2 μg 12 hrs, larvae L3    100 Rotenone 8 μg 12 hrs, larvae L3    96 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    180 cold shock, 4-day adult    152 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    87 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    120 Copper 0.5 mM 12 hrs, larvae L3    245 Copper 15 mM 48 hrs, 4-day adult    90 Zinc 5 mM 12 hrs, larvae L3    194 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    113 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    113 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    103 Rotenone 2 μg 12 hrs, larvae L3    100 Rotenone 8 μg 12 hrs, larvae L3    96 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (180) cold shock, 4-day adult  (152) heat shock, 4-day adult  (107) Cadmium 50 mM 6 hrs, larvae L3  (87) Cadmium 50 mM 12 hrs, larvae L3  (83) Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (120) Copper 0.5 mM 12 hrs, larvae L3  (245) Copper 15 mM 48 hrs, 4-day adult  (90) Zinc 5 mM 12 hrs, larvae L3  (194) Zinc 4.5 mM 48 hrs, 4-day adult  (92) Ethanol 2.5% 3 hrs, larvae L3  (113) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (110) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (88) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (105) Caffeine 25 mg/ml 48 hrs, 4-day adult  (113) Paraquat 5 mM 48 hrs, 4-day adult  (100) Paraquat 10 mM 48 hrs, 4-day adult  (103) Rotenone 2 μg 12 hrs, larvae L3  (100) Rotenone 8 μg 12 hrs, larvae L3  (96) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (180) cold shock, 4-day adult  (152) heat shock, 4-day adult  107 Cadmium 50 mM 6 hrs, larvae L3    87 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult  108 Cadmium 100 mM 48 hrs, 4-day adult  120 Copper 0.5 mM 12 hrs, larvae L3  (245) Copper 15 mM 48 hrs, 4-day adult    90 Zinc 5 mM 12 hrs, larvae L3  (194) Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3  113 Ethanol 5% 3 hrs, larvae L3  109 Ethanol 10% 3 hrs, larvae L3  110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  105 Caffeine 25 mg/ml 48 hrs, 4-day adult  113 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult  103 Rotenone 2 μg 12 hrs, larvae L3    100 Rotenone 8 μg 12 hrs, larvae L3    96 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    180 cold shock, 4-day adult    152 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    87 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    120 Copper 0.5 mM 12 hrs, larvae L3    245 Copper 15 mM 48 hrs, 4-day adult    90 Zinc 5 mM 12 hrs, larvae L3    194 Zinc 4.5 mM 48 hrs, 4-day adult    92 Ethanol 2.5% 3 hrs, larvae L3    113 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    110 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    113 Paraquat 5 mM 48 hrs, 4-day adult    100 Paraquat 10 mM 48 hrs, 4-day adult    103 Rotenone 2 μg 12 hrs, larvae L3    100 Rotenone 8 μg 12 hrs, larvae L3    96 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_09 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • SD10366 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011661 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10701-RD FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Moe Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal MoePL106 lethal, with MoePL106, Scer\GAL4αTub84B.PL MoeTD.Scer\UAS.T:Avic\GFP-EGFP lethal, with MoeTD.Scer\UAS.T:Avic\GFP-EGFP, Scer\GAL4αTub84B.PL MoePL106 lethal, with Scer\GAL4αTub84B.PL MoeTD.Scer\UAS.T:Avic\GFP-EGFP lethal | embryonic stage MoePL54 lethal | first instar larval stage, with Scer\GAL4αTub84B.PL MoeTD.Scer\UAS.P\T lethal | larval stage MoeG0110 MoePL54 lethal | larval stage | recessive MoeG0323 lethal | pharate adult stage MoeG0067 MoeG0258 MoeG0323 lethal | pupal stage MoeG0258 MoeG0323 lethal | pupal stage | recessive MoeG0323 lethal | recessive MoeG0323 MoeG0404 MoeG0415 MoePG26 MoePG67 MoePG82 MoePL54 MoePL106 partially lethal - majority die MoeG0415 partially lethal - majority die, with MoeKN.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 partially lethal - majority die, with MoeKNTA.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 partially lethal - majority die, with MoeKNTD.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 partially lethal - majority die, with MoePL106, Scer\GAL4αTub84B.PL MoeKN.Scer\UAS.P\T.T:Avic\GFP MoeKNTA.Scer\UAS.P\T.T:Avic\GFP MoeKNTD.Scer\UAS.P\T.T:Avic\GFP MoeTA.Scer\UAS.T:Avic\GFP-EGFP partially lethal - majority die, with MoeTA.Scer\UAS.T:Avic\GFP-EGFP, Scer\GAL4αTub84B.PL MoePL106 partially lethal - majority die | female MoeG0404 partially lethal - majority die | male MoeG0404 partially lethal - majority die | recessive MoeG0067 viable MoeBG01015 viable, with Scer\GAL4dpp.blk1 MoedsRNA.327-775.Scer\UAS viable, with Scer\GAL4pnr-MD237 MoeGD5211 Sterility Allele fertile Moehs.T:Avic\GFP Other Phenotypes Allele developmental rate defective | recessive MoeG0323 increased cell death, with Scer\GAL4dpp.blk1 MoedsRNA.327-775.Scer\UAS increased cell death | recessive MoeG0323 increased cell death | somatic clone | third instar larval stage MoePL106 increased cell death | somatic clone | third instar larval stage, with MoeKNTD.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 increased cell death | somatic clone | third instar larval stage, with MoePL106, Scer\GAL4αTub84B.PL MoeKNTD.Scer\UAS.P\T.T:Avic\GFP increased cell death | third instar larval stage MoePL106 size defective MoePL106 size defective | recessive MoeG0323 smell perception defective MoeBG01015 song defective Moe003 visible MoeC858 visible, with MoeKN.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 visible, with MoeKNTA.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 visible, with MoePL106, Scer\GAL4αTub84B.PL MoeKN.Scer\UAS.P\T.T:Avic\GFP MoeKNTA.Scer\UAS.P\T.T:Avic\GFP visible, with Scer\GAL4Bx-MS1096 MoeT559D.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4dpp.3KK MoeC858 visible, with Scer\GAL4dpp.blk1 MoedsRNA.327-775.Scer\UAS visible, with Scer\GAL4MD-638 MoeC858 Phenotype manifest in Allele 1st posterior cell MoeC858 1st posterior cell, with Scer\GAL4dpp.blk1 MoedsRNA.327-775.Scer\UAS basal lamina & dorsal mesothoracic disc & third instar larva MoePL106 cyst progenitor cell, with Scer\GAL4C587 MoedsRNA.327-775.Scer\UAS MoeTA.Scer\UAS.T:Avic\GFP-EGFP MoeTD.Scer\UAS.T:Avic\GFP-EGFP cyst progenitor cell | somatic clone, with Scer\GAL4Act5C.PI MoeTA.Scer\UAS.T:Avic\GFP-EGFP dorsal trunk primordium MoeT559D.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle | non-rescuable maternal effect MoePL106 MoePL54 embryonic/larval midgut primordium, with Scer\GAL4byn-Gal4 MoeScer\UAS.T:Avic\GFP embryonic abdominal segment | non-rescuable maternal effect MoePL106 MoePL54 embryonic hindgut, with Scer\GAL4byn-Gal4 MoeScer\UAS.T:Avic\GFP eye, with MoeKN.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 eye, with MoeKNTA.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 eye, with MoeKNTD.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 eye, with MoePL106, Scer\GAL4αTub84B.PL MoeTA.Scer\UAS.T:Avic\GFP-EGFP MoeKN.Scer\UAS.P\T.T:Avic\GFP MoeKNTA.Scer\UAS.P\T.T:Avic\GFP MoeKNTD.Scer\UAS.P\T.T:Avic\GFP eye, with MoeTA.Scer\UAS.T:Avic\GFP-EGFP, Scer\GAL4αTub84B.PL MoePL106 eye, with Scer\GAL4αTub84B.PL MoeKNTD.Scer\UAS.P\T germline cell | embryonic stage, with Scer\GAL4[-]: MoeEP1652 germline cell | embryonic stage (with Df(1)KA14), with Scer\GAL4[-]: MoeEP1652 germline cell | embryonic stage (with MoeEP1652) MoeG0323 MoeG0415 MoeGT193 germline cell | embryonic stage (with MoeEP1652), with Scer\GAL4[-]: MoeG0323 MoeG0415 MoeGT193 germline cell | embryonic stage (with MoeG0323) MoeEP1652 MoeGT193 germline cell | embryonic stage (with MoeG0323), with Scer\GAL4[-]: MoeEP1652 germline cell | embryonic stage (with MoeG0415) MoeEP1652 MoeGT193 germline cell | embryonic stage (with MoeG0415), with Scer\GAL4[-]: MoeEP1652 germline cell | embryonic stage (with MoeGT193) MoeEP1652 MoeG0323 MoeG0415 germline cell | embryonic stage (with MoeGT193), with Scer\GAL4[-]: MoeEP1652 imaginal disc MoeG0323 imaginal disc | third instar larval stage MoeG0323 nurse cell & actin filament MoeX5 nurse cell & actin filament, with Scer\GAL4Moe-PG26 MoeTA.Scer\UAS.T:Avic\GFP-EGFP MoeTD.Scer\UAS.T:Avic\GFP-EGFP nurse cell & actin filament, with Scer\GAL4nos.UTR.T:Hsim\VP16 MoeTA.Scer\UAS.T:Avic\GFP-EGFP MoeTD.Scer\UAS.T:Avic\GFP-EGFP ommatidium MoePL106 ommatidium | somatic clone MoeX5 oocyte & actin filament MoeX5 oocyte & actin filament | ectopic, with Scer\GAL4nos.UTR.T:Hsim\VP16 MoeTA.Scer\UAS.T:Avic\GFP-EGFP oocyte & cytoskeleton (with MoeEP1652) MoeG0415 oocyte & cytoskeleton (with MoeEP1652), with Scer\GAL4[-]: MoeG0415 oocyte & cytoskeleton (with MoeG0415) MoeEP1652 oocyte & cytoskeleton (with MoeG0415), with Scer\GAL4[-]: MoeEP1652 photoreceptor cell, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4GMR.PF MoedsRNA.818-1326.Scer\UAS photoreceptor cell, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4GMR.PF MoedsRNA.327-775.Scer\UAS photoreceptor cell | somatic clone MoeX5 pole cell | non-rescuable maternal effect MoePL106 MoePL54 presumptive embryonic salivary gland MoeT559D.Scer\UAS.T:Hsap\MYC presumptive embryonic salivary gland, with Scer\GAL4fkh.PH MoeScer\UAS.T:Hsap\MYC retina, with Scer\GAL4ninaE.PD MoeT559A.Scer\UAS.T:Hsap\MYC MoeT559D.Scer\UAS.T:Hsap\MYC rhabdomere & actin filament, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4GMR.PF MoedsRNA.818-1326.Scer\UAS rhabdomere & actin filament, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4hs.PB MoedsRNA.818-1326.Scer\UAS rhabdomere & actin filament, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4GMR.PF MoedsRNA.327-775.Scer\UAS rhabdomere & actin filament, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4hs.PB MoedsRNA.327-775.Scer\UAS rhabdomere & actin filament | somatic clone MoePL54 rhabdomere & cytoskeleton | apical, with Scer\GAL4hs.PB MoeK.T559D.Scer\UAS.T:Hsap\MYC rhabdomere & microvillus, with Scer\GAL4hs.PB MoeK.T559D.Scer\UAS.T:Hsap\MYC rhabdomere & plasma membrane | apical, with Scer\GAL4hs.PB MoeK.T559D.Scer\UAS.T:Hsap\MYC rhabdomere & plasma membrane | apical | somatic clone MoePL54 spindle, with Scer\GAL4C587 MoedsRNA.327-775.Scer\UAS MoeTA.Scer\UAS.T:Avic\GFP-EGFP MoeTD.Scer\UAS.T:Avic\GFP-EGFP wing MoeC858 wing, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.818-1326.Scer\UAS wing, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.327-775.Scer\UAS wing, with Scer\GAL4MD-638 MoeC858 wing blade MoePL106 wing blade, with MoeKN.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 wing blade, with MoeKNTA.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 wing blade, with MoePL106, Scer\GAL4αTub84B.PL MoeKN.Scer\UAS.P\T.T:Avic\GFP MoeKNTA.Scer\UAS.P\T.T:Avic\GFP wing blade, with Scer\GAL4Bx-MS1096 MoeT559D.Scer\UAS.T:Hsap\MYC wing blade, with Scer\GAL4dpp.blk1 MoedsRNA.327-775.Scer\UAS wing disc MoeG0323 MoeC858 wing disc, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.818-1326.Scer\UAS wing disc, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.327-775.Scer\UAS wing disc | somatic clone | third instar larval stage MoePL106 wing disc | somatic clone | third instar larval stage, with MoeKNTD.Scer\UAS.P\T.T:Avic\GFP, Scer\GAL4αTub84B.PL MoePL106 wing disc | somatic clone | third instar larval stage, with MoePL106, Scer\GAL4αTub84B.PL MoeKNTD.Scer\UAS.P\T.T:Avic\GFP wing disc | third instar larval stage MoePL106 wing disc | third instar larval stage, with Scer\GAL4dpp.blk1 MoedsRNA.327-775.Scer\UAS wing hinge MoeC858 wing hinge, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.818-1326.Scer\UAS wing hinge, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.327-775.Scer\UAS wing vein, with MoedsRNA.327-775.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.818-1326.Scer\UAS wing vein, with MoedsRNA.818-1326.Scer\UAS, Scer\GAL4MD-638 MoedsRNA.327-775.Scer\UAS wing vein, with Scer\GAL4dpp.3KK MoeC858 wing vein L3 MoeC858
Classical Alleles ( 60 )
For All Classical Alleles Show
Allele of Moe Class Mutagen Stocks Known lesion MoeG0404 P-element activity 2 -- MoeG0417a 2 -- MoeG0323 amorphic allele - genetic evidence P-element activity 1 Yes Moe5-HA-1851 1 -- Moe5-HA-2142 1 -- MoeBG02548 P-element activity 1 -- MoeCB-5184-3 1 -- Moed01211 P-element activity 1 -- Moed04116 1 -- Moee02369 1 -- Moee03902 1 -- Moee04400 1 -- MoeEP1652 P-element activity 1 -- MoeEY12769 1 -- Moef03979 1 -- Moef06122 1 -- MoeG0067 P-element activity 1 -- MoeG0415 P-element activity 1 -- MoeGS1014 1 Yes MoeGS7455 1 -- MoeNP0343 1 -- MoeNP1621 1 -- MoeNP2456 1 -- MoeNP2677 1 -- MoeNP3506 1 -- MoeNP5010 1 -- MoeNP5069 1 -- MoeNP5074 1 -- MoeNP6104 1 -- Moe003 0 -- Moe5-HA-2571 0 -- Moe5-HA-2574 0 -- Moe5-HA-2579 0 -- Moe5-SZ-3689 0 -- MoeBG01015 0 Yes MoeC858 P-element activity 0 Yes MoeCB-0537-3 0 -- Moed03169 0 -- Moed04603 0 -- Moed09175 0 -- Moee04353 0 -- MoeEP1373 P-element activity 0 -- MoeEP1652EX2 P-element activity 0 Yes Moef06459 0 -- Moef06488 0 -- MoeG0110 P-element activity 0 -- MoeG0258 P-element activity 0 -- MoeG0415EX6 P-element activity 0 -- MoeG0460b 0 -- MoeGG01003 0 -- MoeGG01111 0 -- MoeGS6024 0 Yes MoeGT193 P-element activity 0 -- MoeNP4069 0 -- MoePG26 Delta2-3 0 -- MoePG67 Delta2-3 0 -- MoePG82 Delta2-3 0 Yes MoePL106 Delta2-3 0 -- MoePL54 Delta2-3 0 -- MoeX5 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 46 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Moe Class Mutagen Stocks Known lesion MoeGMA.Scer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion 3 Yes Moesqh.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes Moebtl.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes MoedsRNA.327-775.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes MoeGD5211 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MoeHM05265 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MoeHMS00886 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MoeJF01610 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MoeK.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 1 Yes MoeK.T559D.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 1 Yes MoeABD.ptc.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Moeact.Scer\UAS.P\T.T:Disc\RFP-mCherry 0 -- Moebtl.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeDB.nos.nos3'UTR,T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes MoeDNLS.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoedsRNA.818-1326.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Moehs.PH in vitro construct - regulatory fusion 0 Yes Moehs.PM in vitro construct - regulatory fusion 0 Yes Moehs.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeK.Scer\UAS.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes MoeKK108480 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Moekn.4-0.9.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeKN.Scer\UAS.P\T.T:Avic\GFP in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeKN.Scer\UAS.P\T in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes MoeKNTA.Scer\UAS.P\T.T:Avic\GFP in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeKNTA.Scer\UAS.P\T in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes MoeKNTD.Scer\UAS.P\T.T:Avic\GFP in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeKNTD.Scer\UAS.P\T in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes MoeNIG.10701R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Moenos.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeScer\UAS.P\T.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeScer\UAS.P\T in vitro construct - regulatory fusion 0 Yes MoeScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes MoeScer\UAS.T:Disc\RFP-mRFP.cKa 0 -- MoeScer\UAS.T:Disc\RFP-mRFP in vitro construct - coding region fusion 0 Yes MoeScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeSix4.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Moesqh.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MoeT559A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes MoeT559D.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes MoeTA.Scer\UAS.P\T in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes MoeTA.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes MoeTD.Scer\UAS.P\T in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes MoeTD.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes MoeWT.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)KA14 (Jankovics et al., 2002) Df(1)lz-90b24 (Speck et al., 2003)
Duplicated in	Dp(1;3)DC199 (Popodi et al., 2010-) Dp(1;Y)619 (Speck et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5211} NA P{KK108480} NA P{NIG.10701R} NA P{TRiP.HM05265} NA P{TRiP.HMS00886} NA P{TRiP.JF01610} NA P{UAS-GMA} NA P{UAS-Moe::GFP} NA P{UAS-Moe.GFP.K} NA P{UAS-Moe.IR.327-775} NA P{UAS-Moe.IR.818-1326} NA P{UAS-Moe.MYC.K} NA P{UAS-Moe.myc.T559A} NA P{UAS-Moe.myc.T559D} NA P{UAS-Moe.myc} NA P{UAS-Moe.RFP.K} NA P{UAS-Moe.RFP} NA P{UAS-Moe.T559D.MYC} NA P{UAS-Moe.TA::GFP} NA P{UAS-Moe.TD::GFP} NA P{UAS-Moe.WT::GFP} NA P{UAS-pHMA} NA P{UASp-mCherry-actMoe} NA P{UASp-mCherry-Moesin} NA P{UASp-Moe.GFP.KN} NA P{UASp-Moe.GFP.KNTA} NA P{UASp-Moe.GFP.KNTD} NA P{UASp-Moe.KN} NA P{UASp-Moe.KNTA.P\T} NA P{UASp-Moe.KNTD} NA P{UASp-Moe.TA} NA P{UASp-Moe.TD} NA P{UASp-Moe.WT} NA P{UASp-MoeDNLS-GFP} NA P{UASp-Moe-GFP} NA heat-shock construct P{hs-GFP-Moe} NA characterization construct P{btl-Moe::GFP} NA P{btl-moe.mRFP1} NA P{kn-moeGFP.4-0.9} NA P{nos-Moe.EGFP.nos3'UTR} NA P{nos-Moe.RFP} NA P{ptc-EGFP-Moe.ABD} NA P{sChMCA} NA P{sGMCA} NA P{Six4-EGFP-Moe.ABD} NA P{Ubi-pHMA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}MoeEP1373 NA P{EP}MoeEP1652 NA P{EPgy2}MoeEY12769 NA P{GSV1}MoeC858 NA P{GSV1}MoeGS1014 NA P{GSV2}MoeGS7455 NA P{GSV3}MoeGS6024 NA P{Mae-UAS.6.11}MoeGG01003 NA P{Mae-UAS.6.11}MoeGG01111 NA P{XP}Moed01211 NA P{XP}Moed03169 NA P{XP}Moed04116 NA P{XP}Moed04603 NA P{XP}Moed09175 NA miscellaneous insertions P{EGFP.GT}MoeGT193 NA P{GT1}MoeBG01015 NA P{GT1}MoeBG02548 NA P{RS3}MoeCB-0537-3 NA P{RS3}MoeCB-5184-3 NA P{RS5}Moe5-HA-1851 NA P{RS5}Moe5-HA-2142 NA P{RS5}Moe5-HA-2571 NA P{RS5}Moe5-HA-2574 NA P{RS5}Moe5-HA-2579 NA P{RS5}Moe5-SZ-3689 NA PBac{RB}Moee02369 NA PBac{RB}Moee03902 NA PBac{RB}Moee04353 NA PBac{RB}Moee04400 NA PBac{WH}Moef03979 NA PBac{WH}Moef06122 NA PBac{WH}Moef06459 NA PBac{WH}Moef06488 NA insertion of enhancer trap binary system P{GawB}Moe003 No P{GawB}MoeNP0343 No P{GawB}MoeNP1621 No P{GawB}MoeNP2456 No P{GawB}MoeNP2677 No P{GawB}MoeNP3506 No P{GawB}MoeNP4069 No P{GawB}MoeNP5010 No P{GawB}MoeNP5069 No P{GawB}MoeNP5074 No P{GawB}MoeNP6104 No P{GawB}MoePG26 No P{GawB}MoePG67 No P{GawB}MoePG82 No insertion of enhancer trap P{lacW}l(1)G0187G0187 No P{lacW}MoeG0067 No P{lacW}MoeG0110 No P{lacW}MoeG0258 No P{lacW}MoeG0323 No P{lacW}MoeG0404 No P{lacW}MoeG0415 No P{lacW}MoeG0417a No P{lacW}MoeG0460b No P{lacW}MoePL54 No P{lacW}MoePL106 No
Gene Ontology: Function, Process & Cellular Component ( 35 unique terms )
Terms Based on Experimental Evidence ( 21 terms )
Molecular Function
CV term Evidence References
phosphatidylinositol-4,5-bisphosphate binding inferred from direct assay (Roch et al., 2010) protein binding inferred from physical interaction with Mer (McCartney and Fehon, 1996)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Polesello et al., 2002) determination of left/right symmetry inferred from mutant phenotype (Taniguchi et al., 2007) establishment or maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Speck et al., 2003) establishment or maintenance of polarity of larval imaginal disc epithelium inferred from mutant phenotype (Speck et al., 2003) male courtship behavior, veined wing generated song production inferred from mutant phenotype (Moran and Kyriacou, 2009) olfactory behavior inferred from mutant phenotype (Sambandan et al., 2006) oocyte anterior/posterior axis specification inferred from mutant phenotype (Polesello et al., 2002) regulation of actin cytoskeleton organization inferred from mutant phenotype (Kunda et al., 2008) regulation of membrane potential in photoreceptor cell inferred from direct assay (Chorna-Ornan et al., 2005) rhabdomere development inferred from mutant phenotype (Karagiosis and Ready, 2004) rhabdomere membrane biogenesis inferred from mutant phenotype (Karagiosis and Ready, 2004)
Cellular Component
CV term Evidence References
colocalizes_with actin cytoskeleton inferred from direct assay (Roch et al., 2010) colocalizes_with actin filament inferred from direct assay (Vilmos et al., 2009) cell cortex inferred from direct assay (Vilmos et al., 2009, Roch et al., 2010) cytoplasm inferred from direct assay (Vilmos et al., 2009) colocalizes_with cytoplasm inferred from direct assay (Roch et al., 2010) NOT fusome inferred from direct assay (de Cuevas et al., 1996) nucleus inferred from direct assay (Vilmos et al., 2009) colocalizes_with nucleus inferred from direct assay (Roch et al., 2010) plasma membrane inferred from direct assay (McCartney and Fehon, 1996, de Cuevas et al., 1996, Verdier et al., 2006) colocalizes_with spindle inferred from direct assay (Vilmos et al., 2009)
Terms Based on Predictions or Assertions ( 16 terms )
Molecular Function
CV term Evidence References
actin binding non-traceable author statement (Gibson and Perrimon, 2003, Swiss-Prot Project Members, 1995.9.1) cytoskeletal protein binding inferred from electronic annotation with InterPro:IPR000798, InterPro:IPR008954, InterPro:IPR011174, InterPro:IPR011259 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
actin filament-based process non-traceable author statement (Baum, 2002) anterior/posterior pattern specification traceable author statement (Polesello and Payre, 2004) cytoskeleton organization traceable author statement (Polesello and Payre, 2004) establishment or maintenance of apical/basal cell polarity traceable author statement (Polesello and Payre, 2004) eye photoreceptor cell development traceable author statement (Polesello and Payre, 2004) morphogenesis of an epithelium traceable author statement (Polesello and Payre, 2004) pole plasm assembly traceable author statement (Polesello and Payre, 2004) pole plasm protein localization traceable author statement (Polesello and Payre, 2004) protein localization traceable author statement (Polesello and Payre, 2004)
Cellular Component
CV term Evidence References
adherens junction non-traceable author statement (Swiss-Prot Project Members, 1995.9.1) cytoplasm non-traceable author statement (Polesello and Payre, 2004) extrinsic to membrane inferred from electronic annotation with InterPro:IPR000798, InterPro:IPR008954, InterPro:IPR011174, InterPro:IPR011259 (FlyBase Curators et al., 2004-) plasma membrane non-traceable author statement (Polesello and Payre, 2004) subapical complex traceable author statement (Medina et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Moe - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Akap200 experimental knowledge based (Guruharsha et al., 2011) Moe - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Moe - Bacc experimental knowledge based (Guruharsha et al., 2011) Moe - CG10425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG10638 experimental knowledge based (Guruharsha et al., 2011) Moe - CG11200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG11267 experimental knowledge based (Guruharsha et al., 2011) Moe - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG14715 experimental knowledge based (Guruharsha et al., 2011) Moe - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG1561 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG16817 experimental knowledge based (Guruharsha et al., 2011) Moe - CG17323 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG17337 experimental knowledge based (Guruharsha et al., 2011) Moe - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG2767 experimental knowledge based (Guruharsha et al., 2011) Moe - CG2852 experimental knowledge based (Guruharsha et al., 2011) Moe - CG2862 experimental knowledge based (Guruharsha et al., 2011) Moe - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG4598 experimental knowledge based (Guruharsha et al., 2011) Moe - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG5844 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG6084 experimental knowledge based (Guruharsha et al., 2011) Moe - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - CG8036 experimental knowledge based (Guruharsha et al., 2011) Moe - CG8132 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Chd64 experimental knowledge based (Guruharsha et al., 2011) Moe - Crc experimental knowledge based (Guruharsha et al., 2011) Moe - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Df31 experimental knowledge based (Guruharsha et al., 2011) Moe - Dim1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Eb1 experimental knowledge based (Guruharsha et al., 2011) Moe - Ef2b experimental knowledge based (Guruharsha et al., 2011) Moe - EndoGI experimental knowledge based (Guruharsha et al., 2011) Moe - Eno experimental knowledge based (Guruharsha et al., 2011) Moe - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Moe - Fim experimental knowledge based (Guruharsha et al., 2011) Moe - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Moe - Gdi experimental knowledge based (Guruharsha et al., 2011) Moe - GstE6 experimental knowledge based (Guruharsha et al., 2011) Moe - GstO3 experimental knowledge based (Guruharsha et al., 2011) Moe - Hop experimental knowledge based (Guruharsha et al., 2011) Moe - Hsc70Cb experimental knowledge based (Guruharsha et al., 2011) Moe - Inos experimental knowledge based (Guruharsha et al., 2011) Moe - Lamp1 experimental knowledge based (Guruharsha et al., 2011) Moe - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Moe - Men experimental knowledge based (Guruharsha et al., 2011) Moe - Nacα experimental knowledge based (Guruharsha et al., 2011) Moe - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Nlp experimental knowledge based (Guruharsha et al., 2011) Moe - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) Moe - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - PHGPx experimental knowledge based (Guruharsha et al., 2011) Moe - Pdi experimental knowledge based (Guruharsha et al., 2011) Moe - Pgd experimental knowledge based (Guruharsha et al., 2011) Moe - Pgk experimental knowledge based (Guruharsha et al., 2011) Moe - Pglym78 experimental knowledge based (Guruharsha et al., 2011) Moe - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Prosα1 experimental knowledge based (Guruharsha et al., 2011) Moe - Prosβ5 experimental knowledge based (Guruharsha et al., 2011) Moe - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Moe - RhoGDI experimental knowledge based (Guruharsha et al., 2011) Moe - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Sh3β experimental knowledge based (Guruharsha et al., 2011) Moe - TER94 experimental knowledge based (Guruharsha et al., 2011) Moe - Tal experimental knowledge based (Guruharsha et al., 2011) Moe - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - Trxr-1 experimental knowledge based (Guruharsha et al., 2011) Moe - Tudor-SN experimental knowledge based (Guruharsha et al., 2011) Moe - Uch experimental knowledge based (Guruharsha et al., 2011) Moe - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - ave anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - awd experimental knowledge based (Guruharsha et al., 2011) Moe - boi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - capt experimental knowledge based (Guruharsha et al., 2011) Moe - chic experimental knowledge based (Guruharsha et al., 2011) Moe - cib experimental knowledge based (Guruharsha et al., 2011) Moe - eEF1δ experimental knowledge based (Guruharsha et al., 2011) Moe - eIF-5A experimental knowledge based (Guruharsha et al., 2011) Moe - fabp experimental knowledge based (Guruharsha et al., 2011) Moe - fax experimental knowledge based (Guruharsha et al., 2011) Moe - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - flr experimental knowledge based (Guruharsha et al., 2011) Moe - mRpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - mus209 experimental knowledge based (Guruharsha et al., 2011) Moe - regucalcin experimental knowledge based (Guruharsha et al., 2011) Moe - robl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Moe - scf experimental knowledge based (Guruharsha et al., 2011) Moe - scu experimental knowledge based (Guruharsha et al., 2011) Moe - smt3 experimental knowledge based (Guruharsha et al., 2011) Moe - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Moe allele Gene References MoeG0323 dsh (Speck et al., 2003) Rho1 (Speck et al., 2003) rok (Speck et al., 2003) zip (Speck et al., 2003) MoeTD.Scer\UAS.T:Avic\GFP-EGFP slik (Hipfner et al., 2004) unspecified Nsf2 (Laviolette et al., 2005) pbl (Gregory et al., 2007) Ret (Read et al., 2005) Rho1 (Molnar and de Celis, 2006) smo (Molnar and de Celis, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58274 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011661 DroID - A comprehensive database of gene and protein interactions. • FBgn0011661 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31816
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QRHPJ Dipteran inclusive ortholog search EOG6S7JZB Insect inclusive ortholog search EOG6R4XZ0 Arthropod inclusive ortholog search EOG6M37QT Metazoa inclusive ortholog search EOG65J4QN
Orthologs in Drosophila Species (EOG6QRHPJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Moe     Drosophila simulans   Dsim\GD16093 Y   Drosophila sechellia   Dsec\GM13695 Y   Drosophila erecta   Dere\GG19021 Y   Drosophila yakuba   Dyak\GE17431 Y   Drosophila ananassae   Dana\GF19124 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10507 Y   Drosophila persimilis   Dper\GL13033 Y   Drosophila willistoni   Dwil\GK16883 Y   Drosophila virilis   Dvir\GJ15179 Y   Drosophila mojavensis   Dmoj\GI15567 Y   Drosophila grimshawi   Dgri\GH12073 Y
Orthologs in non-Drosophila Dipterans (EOG6S7JZB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\Moe   Anopheles gambiae Malaria mosquito  Agam\MOEH_ANOGA   Culex quinquefasciatus Southern house mosquito  Cqui\Moe
Orthologs in non-Dipteran Insects (EOG6R4XZ0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47960   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG031040   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18202   Atta cephalotes Leafcutter ant  Acep\ACEP19546   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16404   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16329   Linepithema humile Argentine ant  Lhum\LH17145   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27194   Solenopsis invicta Red fire ant  Sinv\SINV14640   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010009   Bombyx mori Silkmoth  Bmor\BGIBMGA002544   Pediculus humanus Human body louse  Phum\PHUM424430   Tribolium castaneum Red flour beetle  Tcas\TC000998   Tribolium castaneum Red flour beetle  Tcas\TC016331
Orthologs in non-Insect Arthropods (EOG6M37QT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb   Ixodes scapularis Deer tick  Isca\ISCW021858
Orthologs in non-Arthropod Metazoa (EOG65J4QN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\erm-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018705gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028926gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007679gn Y Danio rerio Zebrafish  Drer\nf2a Y Danio rerio Zebrafish  Drer\msnb Y Danio rerio Zebrafish  Drer\msna Y Danio rerio Zebrafish  Drer\nf2b Y Danio rerio Zebrafish  Drer\ezr Y Danio rerio Zebrafish  Drer\ezrl Y Xenopus tropicalis Western clawed frog  Xtro\rdx Y Xenopus tropicalis Western clawed frog  Xtro\msn Y Xenopus tropicalis Western clawed frog  Xtro\nf2 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000010090 Y Xenopus tropicalis Western clawed frog  Xtro\ezr Y Gallus gallus Domestic chicken  Ggal\EZR Y Gallus gallus Domestic chicken  Ggal\NF2 Y Gallus gallus Domestic chicken  Ggal\LOC417537 Y Gallus gallus Domestic chicken  Ggal\RDX Y Gallus gallus Domestic chicken  Ggal\LOC422173 Y Mus musculus House mouse  Mmus\Ezr Y Mus musculus House mouse  Mmus\Nf2 Y Mus musculus House mouse  Mmus\Rdx Y Mus musculus House mouse  Mmus\Msn Y Rattus norvegicus Norway rat  Rnor\Ezr Y Rattus norvegicus Norway rat  Rnor\Msn Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000012237 Y Rattus norvegicus Norway rat  Rnor\Nf2 Y Homo sapiens Human  Hsap\EZR Y Homo sapiens Human  Hsap\MSN Y Homo sapiens Human  Hsap\RDX Y Homo sapiens Human  Hsap\NF2 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\EZR     Hsap\MSN     Hsap\RDX     Hsap\NF2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16093 Drosophila sechellia Dsec\GM13695 Drosophila erecta Dere\GG19021 Drosophila yakuba Dyak\GE17431 Drosophila ananassae Dana\GF19124 Drosophila pseudoobscura pseudoobscura Dpse\GA10507 Drosophila persimilis Dper\GL13033 Drosophila willistoni Dwil\GK16883 Drosophila virilis Dvir\GJ15179 Drosophila mojavensis Dmoj\GI15567 Drosophila grimshawi Dgri\GH12073
Stocks & Reagents
Stocks Listed in FlyBase ( 45 )
Bloomington	31774 P{UAS-GMA}1, w1118 31775 w1118; P{UAS-GMA}2 31776 w1118; P{UAS-GMA}3 35519 w1118 P{sChMCA}12 35520 w1118; P{sChMCA}22
Harvard	- P{XP}Moed01211 - P{XP}Moed04116 - PBac{RB}Moee02369 - PBac{RB}Moee03902 - PBac{RB}Moee04400 - PBac{WH}Moef03979 - PBac{WH}Moef06122
	More stocks available...
Genomic Clones ( 2 )
	BACR23M02 BACR36F08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 410 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10189 RH14719 SD10366
Other clones	DPiM_SD10366 RE21205 RE21217
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08087 AT14767 AT29107 GH06344 GH15250 GH16129 GH16140 GH16147 GH18196 GH22520 GH24339 GH24652 GH24670 GH25250 GM02769 GM02844 GM05017 GM05472 GM06377 GM08051 GM14055 GM19676 GM22059 GM28137 HL01278 LD07491 LD23790 LD28284 LD29781 LD36557 LD39921 LD42068 LD42363 LD45618 LD45679 LP01118 LP01828 LP01891 LP03254 LP03772 LP06992 LP10214 LP10788 LP15326 LP16981 LP17388 LP17873 LP18655 LP22515 LP23487 RE02037 RE02241 RE04165 RE07544 RE09508 RE09576 RE10905 RE11015 RE12466 RE13315 RE15236 RE15792 RE18606 RE19327 RE23282 RE24795 RE26580 RE26863 RE27614 RE29056 RE29640 RE30184 RE30273 RE30795 RE31066 RE32142 RE32452 RE39117 RE39229 RE39720 RE40666 RE40974 RE40986 RE43264 RE47473 RE52865 RE53240 RE53472 RE53619 RE55401 RE56905 RE60252 RE63213 RE63521 RE63725 RE64667 RE66609 RE67934 RE68025 RE68046 RE68672 RE70315 RE71216 RE73827 RE74507 RE74827 RE75117 RH31351 RH32396 RH33076 RH34180 RH40640 RH42271 RH48764 RH67621 SD01336 SD02976 SD04305 SD05086 SD05688 SD05805 SD05865 SD06423 SD07708 SD07819 SD08341 SD10679 SD11594 SD15387 SD20132 SD20258 SD21076 SD21954 SD22970 SD24119 SD26166 SD27825
Other clones	13342 15879 16300 35264 39014 44966 66534 82110 156777 180964 190622 277231 277434 473478 522057 522135 522139 522565 523461 523949 524284 524329 524688 524974 525462 525597 525729 527770 527772 527998 528038 528169 528237 533512 533544 533587 533603 542449 542484 542755 542801 542878 556954 557128 557717 557741 561921 561934 561990 562114 568848 568874 568964 569128 569449 569600 569656 569789 571113 571142 571240 571273 576528 bs38f05 CK01.7C.G2 CK01.24D.E12 CK01.95C.G4 CK01.102C.F12 CK01.104B.G6 CK01.144A.H6 Dmel_dig_002541_0580_2564 Dmel_neb_009234_0870_1046 Dmel_neb_009511_0908_3411 Dmel_neb_012697_0910_2802 Dmel_neb_013046_0818_3147 Dmel_neb_014488_0820_3419 Dmel_neb_015928_0613_1461 EK010543 EK022239 EK032007 EK074358 EK114301 EK118663 EK146017 EK160462 EK163830 EK171602 EK186304 EK215336 EK259827 EK263929 EK291024 EK292654 EK304340 EN00138 EN00403 EN01263 EN01432 EN01436 EN01451 EN01512 EN02352 EN03422 EN03813 EN03947 EN04403 EN04463 EN05114 EN05159 EN05309 EN05403 EN05408 EN05736 EN06260 EN06547 EN06706 EN06758 EN07108 EN07924 EN07926 EN08219 EN08259 EN08659 EN09312 EN09645 EN09725 EN09815 EN09836 EN10633 EN10721 EN11348 EN11531 EN11744 EN12008 EN12113 EN12248 EN12319 EN13361 EN13418 EN13515 EN13603 EN13733 EN14038 EN14112 EN14250 EN14610 EN14919 EN15229 EN15337 EN15621 EN15906 EN16116 EN16153 EN16421 EN16462 EN17847 EP02304 FGC022B08 FGM210A11 FGM222F01 FGM316D05 GH06028 GH11719 LP23788 RE01359 RE05166 RE07767 RE15669 RE26160 RE33609 RE42573 RE43288 RE44005 RE44351 RE45018 RE65925 RH29082 RH43695 RH63551 RP004016782 RP004036269 RP004038937 RP004054766 RP004086888 RP004087428 RP004102571 RP004107310 RP004115933 RP004116514 RP004140103 RP004152918 RP004155584 RP004156867 RP004158207 RP004175384 RP004177053 RP004181495 RP004203732 RP004207377 RP004209510 RP004210501 RP004217716 RP004217906 RP004221152 RP004225916 RP004226259 RP004229951 RP004230383 RP004232532 RP004234447 RP004236808 RP004237198 RP004239041 RP004241638 RP004246603 RP004247157 RP004248055 RP004249101 RP004251196 RP004253086 RP004253808 RP004255351 RP004256200 RP004259657 RP004262105 RP004263160 RP004265171 RP004269945 RP004328698 RP004339335 RP004358253 RP004358812 RP004365220 RP004366422 RP004366852 RP004375865 RP004384116 RP004409645 RP004413828 RP004416395 RP004420521 RP004420584 RP004433476 RP004436517 RP004438384 RP004472855 RP004479208 RP004482626 RP004505203 RP004506524 RP004507601 RP004519304 RP004523266 RP004527132 RP004530030 RP004533427 RP004538144 RP004539476 RP004541609 RP004547885 RP004555633 UT01016 UUGC0054 UUGC0299 UUGC0554 UUGC0822 UUGC0966
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011661 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31816
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Moe anon-WO03040301.155 anon-WO03040301.157 anon-WO03040301.159 anon-WO03040301.161 (FlyBase, 1996-) Source for merge of: Moe l(1)G0323 (Speck et al., 2003) Source for merge of: Moe l(1)G0415 (Jankovics et al., 2002)
Additional comments	"l(1)G0187" may affect "Moe". (Peter et al., 2002) Source for merge of Moe anon-WO03040301.155 anon-WO03040301.157 anon-WO03040301.159 anon-WO03040301.161 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	The effect of slik on Mer is not mediated through its effects on Moe activation. (Hughes and Fehon, 2006) Mutations that impair phosphorylation of Moe abolish the movement of Moe upon illumination and result in light-activated degeneration of the photoreceptor cells. (Chorna-Ornan et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Moe is required to maintain apical-basal polarity, epithelial integrity and correct actin distribution in imaginal disc cells. (Speck et al., 2003) Mutant phenotypes include lethality, female sterility and imperfect eye and wing development, in addition to a maternal effect loss of germ cells in embryos. (Jankovics et al., 2002) Alteration of the actin cytoskeleton in oocytes resulting from Moe mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. Moe mutations also lead to defects in the actin cytoskeleton of nurse cells and consequently produce severe defects in nurse-cell shape. (Polesello et al., 2002) Moe is required during oogenesis for anchoring microfilaments to the oocyte cortex. (Polesello et al., 2002) Transcript induced by MMS treatment of S1CII cells. (Akaboshi and Inoue, 1997) The Moe gene product is not a component of fusome. (de Cuevas et al., 1996) Mer and Moe are frequently coexpressed in developing tissues, but their subcellular localisations are distinct. Moe shows continuous plasma membrane association and Mer is localised in punctate structures that are associated with both the plasma membrane and the cytoplasm. (McCartney and Fehon, 1996) A yeast phenotypic screen efficiently identifies conserved genes from more complex organisms and sheds light on their potential in vivo functions. Induced expression of Moe proteins causes aberrant cell shapes reflecting defects in cytokinesis and/or cell shape maintenance. (Edwards et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080343 NM_167168 NM_167169 NM_167170 NM_206664 NM_206665 NM_206666 NM_206667 NM_206668 NM_206669 NM_001258654 NM_001258655 NM_001272432 RefSeq (Proteins) • NP_525082 NP_727290 NP_727291 NP_727292 NP_996387 NP_996388 NP_996389 NP_996390 NP_996391 NP_996392 NP_001245583 NP_001245584 NP_001259361 DDBJ / EMBL / GenBank • AAA19857 AAA65059 AAB48934 AAF46415 AAF46416 AAF46417 AAF46418 AAL40000 AAS65294 AAS65295 AAS65296 AAS65297 AAS65298 AAS65299 AFH07297 AFH07298 AGB95204 AI543570 AQ025424 AQ254784 AW944629 AX777301 AX777303 AX777305 AX777307 AY069855 BH011525 CZ472093 CZ472094 L38909 U08218 U23798 Entrez Gene - A searchable database of RefSeq genes. • 31816 UniProtKB/Swiss-Prot • P46150
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • FERM domain (IPR000299) Ezrin/radixin/moesin like (IPR000798) Moesin (IPR008954) Ezrin/radixin/moesin (IPR011174) Ezrin/radixin/moesin, C-terminal (IPR011259) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) FERM, N-terminal (IPR018979) FERM, C-terminal PH-like domain (IPR018980) FERM conserved site (IPR019747) FERM central domain (IPR019748) Band 4.1 domain (IPR019749) Band 4.1 family (IPR019750) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD10366
Linkouts
	BioGRID - A database of protein and genetic interactions • 58274 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011661 DroID - A comprehensive database of gene and protein interactions. • FBgn0011661 DRSC - Results from RNAi screens. • FBgn0011661 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011661 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10701-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011661 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31816 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/moesin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31816 modMine - Data generated by the modENCODE project. • FBgn0011661
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	anon-WO03040301.155   anon-WO03040301.157   anon-WO03040301.159   anon-WO03040301.161   CG10701 (Bourbon et al., 2002, Goldstein and Gunawardena, 2000, Laviolette et al., 2005, Rogers et al., 2003, Stuart et al., 2007, Molnar et al., 2006, Lebo et al., 2009, Chang et al., 2008, Perkins et al., 2009, Ni et al., 2008, Kim et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Yano et al., 2012) D17 (Edwards et al., 1994) Dmoe (Polesello and Payre, 2004, Medina et al., 2002, Polesello et al., 2002, Jankovics et al., 2002, Seabrooke and Stewart, 2008, McNeil et al., 2009) dMoe (Foussard et al., 2007) EMR1 (Winge, 1995.3.30) Emr1   ERM (Nikiforova and Fehon, 2002) gma (Schönbauer et al., 2011) l(1)G0067 (Schaefer et al., 1999.6.15, Schaefer et al., 1999.3.29, ) l(1)G0323 (Schaefer et al., 1999.6.15, ) l(1)G0404 (Schaefer et al., 1999.8.12, ) l(1)G0415 (Schaefer et al., 1999.8.12, ) Moe (Solon et al., 2009, Kerman et al., 2007, Ramos et al., 2006, Garcia et al., 2007, Stuart et al., 2007, Fox and Peifer, 2007, Hughes and Fehon, 2006, Macdonald and Long, 2007, Carreno et al., 2008, Molnar et al., 2006, Bakal et al., 2007, Li et al., 2007, Taniguchi et al., 2007, Robida et al., 2007, Toyama et al., 2008, Moran and Kyriacou, 2009, Mukherjee et al., 2011, Cheshire et al., 2008, Xu et al., 2011, Jankovics and Brunner, 2006, Blankenship et al., 2006, Cavey et al., 2008, Chang et al., 2008, Nishimura et al., 2007, Homem and Peifer, 2008, Gervais et al., 2008, Polesello and Tapon, 2007, Kunda et al., 2008, Rauzi et al., 2008, Cabernard and Affolter, 2005, Grusche et al., 2009, Dworkin et al., 2009, Genevet et al., 2009, Vilmos et al., 2009, Zanet et al., 2009, Wolfstetter et al., 2009, Forster et al., 2010, Gervais and Casanova, 2010, Robinson et al., 2010, David et al., 2010, Monier et al., 2010, Neisch et al., 2010, Roch et al., 2010, Neubueser and Hipfner, 2010, Simone and DiNardo, 2010, Tajiri et al., 2010, Blanchard et al., 2010, Popodi et al., 2010-, Ling et al., 2010, Foussard et al., 2010, Letizia et al., 2011, Georgiou and Baum, 2010, Hughes et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Förster and Luschnig, 2012) moe (Ribeiro et al., 2004, Bourbon et al., 2002, Edwards et al., 1997, Molnar and de Celis, 2006, Laviolette et al., 2005, Weil et al., 2010, Boukhatmi et al., 2012, Layton et al., 2009, Chanut-Delalande et al., 2007, Abruzzi et al., 2011, Caussinus et al., 2008, Tsarouhas et al., 2007, Royou et al., 2008, Inoue and Hayashi, 2007, Sano et al., 2005, Kerman et al., 2008, Ricardo and Lehmann, 2009, Ricardo and Lehmann, 2009, Rodriguez-Diaz et al., 2008, McNeil et al., 2009, Wang et al., 2009, Vlisidou et al., 2009, Sawyer et al., 2009, Wang et al., 2010, Araújo and Casanova, 2011, Khuong et al., 2010, Cobreros-Reguera et al., 2010, Khuong et al., 2010, Keleman et al., 2005, Renault et al., 2010) moesin/ezrin/radixin homolog mRNA (Edwards, 1994.3.30)
Name Synonym	DMoesin (Mueller and Bossinger, 2003, Knust and Bossinger, 2002, Medina et al., 2003, Medina et al., 2002, Medina et al., 2002, Verdier et al., 2006, Williams et al., 2004) Dmoesin (Gibson and Perrimon, 2003, Miller, 2003, Cereijido et al., 2003, Baum, 2002, Anonymous, 2002, Karagiosis and Ready, 2003, Karagiosis and Ready, 2002, Muller, 2000, Fehon, 1995.1.12, McCartney and Fehon, 1994, McCartney and Fehon, 1995, Polesello and Payre, 2004, de Cuevas et al., 1996, McCartney and Fehon, 1996, Chorna-Ornan et al., 2005, Suzuki and Ohno, 2006, Hegan et al., 2007, Parnas et al., 2009, McNeil et al., 2009, Batchelor et al., 2004) dMoesin (Carreno et al., 2007, Foussard et al., 2007, Roubinet et al., 2007) Ezrin-moesin-radixin-1   Ezrin-Radixin-Moesin (Pilot et al., 2006) Moesin (Solon et al., 2009, de Heredia and Jansen, 2004, Kerman et al., 2007, Neisch et al., 2007, Fehon, 2006, Pilot et al., 2006, Fox et al., 2005, Medina et al., 2006, Gregory et al., 2007, Schwabe et al., 2005, Rogers et al., 2003, Sambandan et al., 2006, Hoopfer et al., 2008, Weis and Nelson, 2006, Silva et al., 2006, Walters et al., 2006, Schneider et al., 2006, Bakal et al., 2007, Hughes and Fehon, 2006, Baum, 2006, Carreno et al., 2008, Galy et al., 2011, Cohen et al., 2011, Mukherjee et al., 2011, Cheshire et al., 2008, Blankenship et al., 2006, Prasad and Montell, 2007, Besse et al., 2007, Cao et al., 2008, Chang et al., 2008, Millard and Martin, 2008, Homem and Peifer, 2008, Gervais et al., 2008, Polesello and Tapon, 2007, Riggs et al., 2007, Kunda et al., 2008, Price et al., 2006, Kerman et al., 2008, Grusche et al., 2009, Lebo et al., 2009, Hijazi et al., 2009, Genevet et al., 2009, Bradu et al., 2009, Webb et al., 2009, Massarwa et al., 2009, Liu et al., 2009, Hughes et al., 2010, Robinson et al., 2010, Siekhaus et al., 2010, Neisch et al., 2010, Roch et al., 2010, Neubueser and Hipfner, 2010, Tajiri et al., 2010, Blanchard et al., 2010, Ling et al., 2010, Tucker et al., 2011, Martin et al., 2009, Foussard et al., 2010, Olguín et al., 2011, Letizia et al., 2011, Khuong et al., 2010, Rotkopf et al., 2011, Mitonaka et al., 2007, Yano et al., 2012, Zanet et al., 2012, Kunda et al., 2012, Förster and Luschnig, 2012) moesin (Dove, 2000, Dorman et al., 2000, Turunen et al., 1998, Somogyi and Rorth, 2004, Franke et al., 2006, Seabrooke and Stewart, 2007, Laplante and Nilson, 2006, Harris and Peifer, 2004, Stramer et al., 2005, Pilot et al., 2006, Oshima et al., 2006, Oshima, 2006, Hozumi et al., 2006, Wheeler et al., 2012, Fishilevich et al., 2010, Seabrooke and Stewart, 2008, Peyre et al., 2006, Sekyrova et al., 2010, Fox and Peifer, 2007, Fei et al., 2002, Sano et al., 2005, Wada et al., 2007, Fernandez-Gonzalez and Zallen, 2011, Ma et al., 2009, Maddox et al., 2007, Tsarouhas et al., 2007, Cavey et al., 2008, Carreno et al., 2008, Royou et al., 2008, Shindo et al., 2008, Inoue and Hayashi, 2007, Weil et al., 2008, Leiss et al., 2009, Golovnina et al., 2005, Widmann and Dahmann, 2009, Kakihara et al., 2008, Wang et al., 2009, Vlisidou et al., 2009, Vilmos et al., 2009, Kondo et al., 2007, Sheng et al., 2009, Sawyer et al., 2009, Stramer et al., 2008, Gervais and Casanova, 2010, Cohen et al., 2010, Fabian et al., 2010, Kaido et al., 2009, Hatan et al., 2011, Cheng et al., 2011, Parkhurst, 2011.4.14, Boggiano et al., 2011, He et al., 2010, Abreu-Blanco et al., 2011, Okumura et al., 2010, Khuong et al., 2010, Geiger et al., 2011, Roch et al., 2010, Sano et al., 2012) Moesin-like (Moran and Kyriacou, 2009)
Secondary FlyBase IDs
	FBgn0013950 FBgn0014345 FBgn0026689 FBgn0027218 FBgn0028282 FBgn0028289 FBgn0066841 FBgn0066842 FBgn0066843 FBgn0066844
References ( 331 )
Generate a list of	All references relating to this gene ( 331 )
List References by type	Research paper  ( 221 ) Supplementary material  ( 18 ) Review  ( 28 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 36 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 )
Recent research papers ( 35 )
	Sung et al., 2013, Curr. Biol. 23(2): 133--138 Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription. [FBrf0220648] Boukhatmi et al., 2012, Development 139(19): 3572--3582 Tup/Islet1 integrates time and position to specify muscle identity in Drosophila. [FBrf0219376] Chatterjee and Bohmann, 2012, PLoS ONE 7(4): e34063 A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture. [FBrf0218067] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Kunda et al., 2012, Curr. Biol. 22(3): 231--236 PP1-Mediated Moesin Dephosphorylation Couples Polar Relaxation to Mitotic Exit. [FBrf0217436] Menant and Karess, 2012, Cell Cycle 11(15): 2856--2863 Inducing "cytokinesis" without mitosis in unfertilized Drosophila eggs. [FBrf0219101] Sano et al., 2012, PLoS ONE 7(12): e52649 The Drosophila Actin Regulator ENABLED Regulates Cell Shape and Orientation during Gonad Morphogenesis. [FBrf0220491] Tsubouchi et al., 2012, Curr. Biol. 22(22): 2124--2134 Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae. [FBrf0219946] Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Wheeler et al., 2012, Dev. Biol. 361(2): 232--244 Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration. [FBrf0217061] Yang et al., 2012, Dev. Biol. 361(2): 412--426 The PP1 phosphatase Flapwing regulates the activity of Merlin and Moesin in Drosophila. [FBrf0217056] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Zanet et al., 2012, J. Cell Biol. 197(4): 477--486 Fascin promotes filopodia formation independent of its role in actin bundling. [FBrf0218285] Abreu-Blanco et al., 2011, J. Cell Biol. 193(3): 455--464 Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. [FBrf0213583] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Araújo and Casanova, 2011, J. Cell Sci. 124(14): 2335--2340 Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels. [FBrf0214024] Barry et al., 2011, Development 138(9): 1759--1769 The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. [FBrf0213458] Boggiano et al., 2011, Dev. Cell 21(5): 888--895 Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. [FBrf0217346] Cheng et al., 2011, Development 138(5): 831--837 Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning. [FBrf0213009] Cohen et al., 2011, J. R. Soc. Interface 8(59): 787--798 The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling. [FBrf0213520] Degennaro et al., 2011, Dev. Cell 20(2): 233--243 Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion. [FBrf0212971] Fernandez-Gonzalez and Zallen, 2011, Phys. Biol. 8(4): 045005 Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. [FBrf0214479] Galy et al., 2011, Dev. Biol. 359(1): 37--46 CYFIP dependent Actin Remodeling controls specific aspects of Drosophila eye morphogenesis. [FBrf0216378] Geiger et al., 2011, PLoS ONE 6(11): e28349 Hole-in-One Mutant Phenotypes Link EGFR/ERK Signaling to Epithelial Tissue Repair in Drosophila. [FBrf0216857] Hatan et al., 2011, J. Cell Biol. 192(2): 307--319 The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures. [FBrf0212807] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Mukherjee et al., 2011, Development 138(11): 2347--2357 The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis. [FBrf0213663] Olguín et al., 2011, Curr. Biol. 21(3): 236--242 Intertissue mechanical stress affects frizzled-mediated planar cell polarity in the Drosophila notum epidermis. [FBrf0212947] Rotkopf et al., 2011, Development 138(13): 2729--2739 The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. [FBrf0213892] Roubinet et al., 2011, J. Cell Biol. 195(1): 99--112 Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. [FBrf0216647] Rumpf et al., 2011, Development 138(6): 1153--1160 Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. [FBrf0213078] Schönbauer et al., 2011, Nature 479(7373): 406--409 Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. [FBrf0216735] Tucker et al., 2011, Dis. Model Mech. 4(1): 126--134 Ena drives invasive macrophage migration in Drosophila embryos. [FBrf0212563] Xu et al., 2011, Development 138(24): 5415--5427 Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin. [FBrf0216741] Ye et al., 2011, J. Neurosci. 31(9): 3309--3319 Differential regulation of dendritic and axonal development by the novel kruppel-like factor dar1. [FBrf0213162] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...