Dmoesin, Dmoe, l(1)G0067, l(1)G0323, l(1)G0404
the sole Drosophila Ezrin, Radixin, Moesin (ERM) protein - involved in cortical cytoskeleton stability - actin-binding protein - functions to promote cortical actin assembly, apical-basal polarity and mitotic spindle organisation - Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Moe using the Feature Mapper tool.
Comment: reported as posterior spiracle specific anlage
GBrowse - Visual display of RNA-Seq signalsView Dmel\Moe in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Moe is required to maintain apical-basal polarity, epithelial integrity and correct actin distribution in imaginal disc cells.
Mutant phenotypes include lethality, female sterility and imperfect eye and wing development, in addition to a maternal effect loss of germ cells in embryos.
Alteration of the actin cytoskeleton in oocytes resulting from Moe mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. Moe mutations also lead to defects in the actin cytoskeleton of nurse cells and consequently produce severe defects in nurse-cell shape.
Moe is required during oogenesis for anchoring microfilaments to the oocyte cortex.
Transcript induced by MMS treatment of S1CII cells.
Mer and Moe are frequently coexpressed in developing tissues, but their subcellular localisations are distinct. Moe shows continuous plasma membrane association and Mer is localised in punctate structures that are associated with both the plasma membrane and the cytoplasm.