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Gene Dmel\Mvl

General Information
Symbol	Dmel\Mvl	Species	D. melanogaster
Name	Malvolio	Annotation symbol	CG3671
Feature type	protein_coding_gene	FlyBase ID	FBgn0011672
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93B7-93B8	Sequence location	3R:16,877,105..16,886,517 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Malvolio is referred to in FlyBase by the symbol Dmel\Mvl (CG3671, FBgn0011672). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: manganese ion transmembrane transporter activity; iron ion transmembrane transporter activity; copper ion transmembrane transporter activity; symporter activity. There is experimental evidence that it is involved in the biological process: iron assimilation; multicellular organismal iron ion homeostasis; copper ion transport; divalent metal ion transport; copper ion import; sensory perception of sweet taste; entry of virus into host cell; transition metal ion transport; copper ion homeostasis; transition metal ion homeostasis. 22 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Natural resistance-associated macrophage protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624392_s_at completely aligns to an exonic region of only a subset of 3 of the 4 FlyBase-annotated transcript isoforms of Mvl. Gene sequence location is 3R:16877105..16886517.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Maruyama et al., 2011, PLoS ONE 6(6): e20901
FB2012_01	Sequence features BKN28406 HFA16752
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93B7-93B8   Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 93B6-93B6     (Cheah, 1995.4.3) 93B6-93B6   (determined by in situ hybridisation)   (Rodrigues et al., 1995)
Experimentally Determined Recombination Data
Location	3- (Rodrigues et al., 1995, Cheah, 1995.4.3)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mvl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mvl-RB FBtr0089521  NM_169944   2648   596 Mvl-RD FBtr0301477  NM_001170197   4782   596 Mvl-RE FBtr0301478  NM_079701   2790   596 Mvl-RF FBtr0306350     2503   605 Mvl-RG FBtr0306351     2221   607
Additional Transcript Data & Comments
Reported size (kB)	3.0 (northern blot) (Rodrigues et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mvl-PB   FBpp0088507   65.5   596   6.11     NP_732584   AAN13847 Mvl-PD   FBpp0290692   65.5   596   6.11     NP_001163668   ACZ94964 Mvl-PE   FBpp0290693   65.5   596   6.11     NP_524425   AAF55839 Mvl-PF   FBpp0297443   66.4   605   6.50       Mvl-PG   FBpp0297444   66.9   607   7.14
Additional Polypeptide Data & Comments
Reported size (kDa)	486 (aa); 53 (kD predicted) (Rodrigues et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Natural resistance-associated macrophage protein (IPR001046)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA820638   AA950440   AE014297 AAF55839   AE014297 AAN13847   AE014297 ACZ94964   AI063612   AI238204   AI257740   AI404556   AI541884   AQ073961   AW942706   AY058543 AAL13772   BF498458   BG636591   BH854525   BI161675   BI161676   BI172439   BI212836   BI213181   BI236266   BI243471   BI364585   BI365035   BI368115   BI370457   BI370523   BI615320   BI624859   BP547997   BT015996 AAV36881   BT044567   BT120016   BT120017   BT120048   BT120178   CK660692   CL705839   CO152757   CO154944   CO185532   CO187166   CO196464   CO266881   CO268979   CO269087   CO303088   CO305540   CO310102   CO319365   CO324067   CO327531   CO338191   CO338720   CO339704   CO340331   CO342384   CZ467028   CZ468636   CZ468637   CZ472483   EC063821   EC086229   EC088827   EC205729   EC218334   EC219246   EC219986   EC225525   EC227264   EC235488   EC237565   EC240881   EC244996   EC247940   EC257592   EC258081   EC258364   EC259261   EC264459   EC264692   EC265289   EC268049   GH942049   GH942068   GH947072   GH952136   GH954749   GH955011   GH958644   GH959165   GH962380   GH962773   GH967818   GH967963   GH968734   GH969226   GH969297   GH970662   GH978659   GH980127   GH980270   GH980851   GH981026   GH982465   U23948 AAA82593
UniProtKB/Swiss-Prot	P49283
UniProtKB/TrEMBL	Q5U196 A4V370
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   tracheal pit | vicinity of   (Rodrigues et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Rodrigues et al., 1995) embryonic stage 10   procephalic segment   (Rodrigues et al., 1995) embryonic stage 16   amnioserosa   (Rodrigues et al., 1995) antenno-maxillary complex   (Rodrigues et al., 1995)
Additional Descriptive Data
	Mvl transcripts are expressed in embryos, downregulated in first and second instar larvae, increase again in third instars and maintained in pupae and adults. Transcripts are first detected by in situ hybridization in germband extended embryos in cells surrounding the tracheal pits and in the procephalic lobe. Staining is observed along the posterior border of segment boundaries during germband retraction. Expression occurs in the amnioserosa and is observed as two rows of cells during dorsal closure. The most prominent neuronal expression is in the cells of the antenno-maxillary complex. (Rodrigues et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011672    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011672 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011672 expression level Developmental Stage   Expression Level embryo 00-02hr    2153 embryo 02-04hr    617 embryo 04-06hr    1492 embryo 06-08hr    1811 embryo 08-10hr    1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6    2136 larva L3 puffstage 7-9    2567 white prepupae new    2519 white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day    1623 adult female 05day    1915 adult female 30day    1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2153) embryo 02-04hr  (617) embryo 04-06hr  (1492) embryo 06-08hr  (1811) embryo 08-10hr  (1442) embryo 10-12hr  (1299) embryo 12-14hr  (1104) embryo 14-16hr  (997) embryo 16-18hr  (882) embryo 18-20hr  (662) embryo 20-22hr  (831) embryo 22-24hr  (845) larva L1  (802) larva L2  (851) larva L3 12hr old  (839) larva L3 puffstage 1-2  (1215) larva L3 puffstage 3-6  (2136) larva L3 puffstage 7-9  (2567) white prepupae new  (2519) white prepupae 12hr  (1074) white prepupae 24hr  (826) pupae 2d postWPP  (720) pupae 3d postWPP  (645) pupae 4d postWPP  (727) adult male 01day  (948) adult male 05day  (940) adult male 30day  (892) adult female 01day  (1623) adult female 05day  (1915) adult female 30day  (1930) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2153) embryo 02-04hr    617 embryo 04-06hr  1492 embryo 06-08hr  (1811) embryo 08-10hr  1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6  (2136) larva L3 puffstage 7-9  (2567) white prepupae new  (2519) white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day  (1623) adult female 05day  (1915) adult female 30day  (1930) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2153 embryo 02-04hr    617 embryo 04-06hr    1492 embryo 06-08hr    1811 embryo 08-10hr    1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6    2136 larva L3 puffstage 7-9    2567 white prepupae new    2519 white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day    1623 adult female 05day    1915 adult female 30day    1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2153 embryo 02-04hr    617 embryo 04-06hr    1492 embryo 06-08hr    1811 embryo 08-10hr    1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6    2136 larva L3 puffstage 7-9    2567 white prepupae new    2519 white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day    1623 adult female 05day    1915 adult female 30day    1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011672 expression level Developmental Stage   Expression Level embryo 00-02hr    2153 embryo 02-04hr    617 embryo 04-06hr    1492 embryo 06-08hr    1811 embryo 08-10hr    1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6    2136 larva L3 puffstage 7-9    2567 white prepupae new    2519 white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day    1623 adult female 05day    1915 adult female 30day    1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2153) embryo 02-04hr  (617) embryo 04-06hr  (1492) embryo 06-08hr  (1811) embryo 08-10hr  (1442) embryo 10-12hr  (1299) embryo 12-14hr  (1104) embryo 14-16hr  (997) embryo 16-18hr  (882) embryo 18-20hr  (662) embryo 20-22hr  (831) embryo 22-24hr  (845) larva L1  (802) larva L2  (851) larva L3 12hr old  (839) larva L3 puffstage 1-2  (1215) larva L3 puffstage 3-6  (2136) larva L3 puffstage 7-9  (2567) white prepupae new  (2519) white prepupae 12hr  (1074) white prepupae 24hr  (826) pupae 2d postWPP  (720) pupae 3d postWPP  (645) pupae 4d postWPP  (727) adult male 01day  (948) adult male 05day  (940) adult male 30day  (892) adult female 01day  (1623) adult female 05day  (1915) adult female 30day  (1930) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2153 embryo 02-04hr    617 embryo 04-06hr  1492 embryo 06-08hr  1811 embryo 08-10hr  1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6  2136 larva L3 puffstage 7-9  (2567) white prepupae new  (2519) white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day  1623 adult female 05day  1915 adult female 30day  1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2153 embryo 02-04hr    617 embryo 04-06hr    1492 embryo 06-08hr    1811 embryo 08-10hr    1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6    2136 larva L3 puffstage 7-9    2567 white prepupae new    2519 white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day    1623 adult female 05day    1915 adult female 30day    1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2153 embryo 02-04hr    617 embryo 04-06hr    1492 embryo 06-08hr    1811 embryo 08-10hr    1442 embryo 10-12hr    1299 embryo 12-14hr    1104 embryo 14-16hr    997 embryo 16-18hr    882 embryo 18-20hr    662 embryo 20-22hr    831 embryo 22-24hr    845 larva L1    802 larva L2    851 larva L3 12hr old    839 larva L3 puffstage 1-2    1215 larva L3 puffstage 3-6    2136 larva L3 puffstage 7-9    2567 white prepupae new    2519 white prepupae 12hr    1074 white prepupae 24hr    826 pupae 2d postWPP    720 pupae 3d postWPP    645 pupae 4d postWPP    727 adult male 01day    948 adult male 05day    940 adult male 30day    892 adult female 01day    1623 adult female 05day    1915 adult female 30day    1930 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011672    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011672 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011672 expression level Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland    660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland    568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland  (660.7) Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland  (568.9) Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland    660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland    568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland    660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland    568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011672 expression level Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland    660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland    568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland  660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland  568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland    660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland    568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    103.8 Larval Midgut    229.6 Larval Hindgut    133.1 Larval Malpighian Tubules    193.6 Larval Fat Body    311.2 Larval Salivary Gland    660.7 Larval Trachea    112.075 Larval Carcass    213.5 Adult Head    103.5 Adult Eye    52.85 Adult Brain    124.5 Adult Thoracic-Abdominal Ganglion    111.1 Adult Crop    88.2 Adult Midgut    168 Adult Hindgut    82.5 Adult Malpighian Tubules    142.9 Adult Fat Body    225.5 Adult Salivary Gland    568.9 Adult Heart    270.55 Adult VirginFemale Spermatheca    206.8 Adult InseminatedFemale Spermatheca    177.1 Adult Ovary    255.4 Adult Testis    90 Adult Male Accessory Gland    123.2 Adult Carcass    109.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    103.5   NA  Eye    52.85   NA  Brain    124.5   103.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    111.1   NA  Crop    88.2   229.6  Midgut    168   133.1  Hindgut    82.5   193.6  Malpighian Tubules    142.9   311.2  Fat Body    225.5   660.7  Salivary Gland    568.9   NA  Heart    270.55   112.075  Trachea    NA   NA  VirginFemale Spermatheca    206.8   NA  InseminatedFemale Spermatheca    177.1   NA  Ovary    255.4   NA  Testis    90   NA  Male Accessory Gland    123.2   213.5  Carcass    109.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011672 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3671-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mvl Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | conditional Mvl97f lethal | embryonic stage | recessive Mvlm13 semi-lethal | conditional | female limited Mvl97f viable MvlEY09165 viable, with Scer\GAL4pnr-MD237 MvlGD3095 Sterility Allele fertile MvlEY09165 Other Phenotypes Allele behavior defective | recessive Mvl8 Mvl23M MvlA-46 MvlJ2 behavior defective | semidominant Mvl5M Mvl12 Mvl97f chemical sensitive Mvl97f taste perception defective Mvl97f Phenotype manifest in Allele
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of Mvl Class Mutagen Stocks Known lesion Mvl5-HA-2861 1 -- Mvl97f P-element activity 1 Yes Mvlc01265 piggyBac transposase 1 -- Mvlc01990 1 -- MvlCB-5250-3 1 -- Mvld01867 P-element activity 1 -- MvlEY09165 P-element activity 1 -- MvlKG02112 P-element activity 1 -- Mvlm13 hypomorphic allele - genetic evidence Delta2-3 1 Yes MvlNP2375 1 -- Mvl12 Delta2-3 0 Yes Mvl23M hypomorphic allele - genetic evidence Delta2-3 0 Yes Mvl5M Delta2-3 0 Yes Mvl8 Delta2-3 0 Yes MvlA-46 hypomorphic allele - genetic evidence Delta2-3 0 Yes Mvlc03382 piggyBac transposase 0 -- Mvld06433 0 -- MvlEP3382 P-element activity 0 -- MvlJ2 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mvl Class Mutagen Stocks Known lesion MvlGD3095 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MvlKK108406 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes MvlScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC43 (Bloomington Drosophila Stock Center, 2003.12.2) Df(3R)e-R1 (Rodrigues et al., 1995) Df(3R)Exel6272 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3095} NA P{KK108406} NA P{UAS-Mvl.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}MvlEP3382 NA P{EPgy2}MvlEY09165 NA P{XP}Mvld01867 NA P{XP}Mvld06433 NA miscellaneous insertions P{5'lacW}Mvlm13 NA P{lacW-Δ5M}Mvl5M NA P{lacW-Δ12}Mvl12 NA P{RS3}MvlCB-5250-3 NA P{RS5}Mvl5-HA-2861 NA P{SUPor-P}MvlKG02112 NA PBac{PB}Mvlc01265 NA PBac{PB}Mvlc01990 NA PBac{PB}Mvlc03382 NA insertion of enhancer trap binary system P{GawB}MvlNP2375 No insertion of enhancer trap P{lacW}Mvl97f No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
copper ion transmembrane transporter activity inferred from mutant phenotype (Southon et al., 2008) iron ion transmembrane transporter activity inferred from mutant phenotype (Orgad et al., 1998) manganese ion transmembrane transporter activity inferred from mutant phenotype (Orgad et al., 1998) symporter activity inferred from genetic interaction with Saccharomyces SMF1, Saccharomyces SMF2, SGD:S000001092, SGD_LOCUS:SMF3 (Techau et al., 2007)
Biological Process
CV term Evidence References
copper ion homeostasis inferred from mutant phenotype (Southon et al., 2008) copper ion import inferred from mutant phenotype (Southon et al., 2008) copper ion transport inferred from mutant phenotype (Southon et al., 2008) divalent metal ion transport inferred from genetic interaction with Saccharomyces SMF1, Saccharomyces SMF2, SGD:S000001092, SGD_LOCUS:SMF3 (Techau et al., 2007) entry of virus into host cell inferred from mutant phenotype (Rose et al., 2011) iron assimilation inferred from direct assay (Bettedi et al., 2011) multicellular organismal iron ion homeostasis inferred from direct assay (Bettedi et al., 2011) sensory perception of sweet taste inferred from mutant phenotype (Rodrigues et al., 1995, Orgad et al., 1998) transition metal ion homeostasis inferred from mutant phenotype (Orgad et al., 1998) transition metal ion transport inferred from mutant phenotype (Orgad et al., 1998)
Cellular Component
CV term Evidence References
cytoplasmic part inferred from direct assay (Southon et al., 2008) membrane inferred from direct assay (Techau et al., 2007) plasma membrane inferred from direct assay (Southon et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from sequence model (Rodrigues et al., 1995) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1) plasma membrane non-traceable author statement (Cheah, 1995.4.3)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mvl allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67461 DroID - A comprehensive database of gene and protein interactions. • FBgn0011672 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42490
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18523 Dere\GG14948 Dgri\GH23182 Dmoj\GI10306 Dper\GL12685 Dpse\GA17603 Dsec\GM15109 Dsim\Mvl Dvir\GJ10160 Dwil\GK14311 Dyak\Mvl
Curated drosophilid orthologs	Dhet\mvl   Dpse\GA17603   Dsim\Mvl   Dyak\Mvl
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP012464-PA Anopheles gambiae (mosquito) XP_001946266.1 Acyrthosiphon pisum (pea aphid) At5g67330.1 Arabidopsis thaliana (wall cress) 29076 Batrachochytrium dendrobatidis (chytrid fungus) 220855 Branchiostoma floridae (lancelet) 246766 Branchiostoma floridae (lancelet) ENSBTAP00000019133 Bos taurus (bovine) CAL0001616 Candida albicans (a form of yeast) CN03608 Caenorhabditis brenneri (small nematode) CBP29070 Caenorhabditis briggsae (nematode) CE41828 Caenorhabditis elegans (worm) ENSCAFP00000011707 Canis familiaris (dog) CAGL0A03476g Candida glabrata (haploid yeast) ENSCINP00000002598 Ciona intestinalis (sea squirt) JA14298 Caenorhabditis japonica (nematode) CML262C Cyanidioschyzon merolae (red alga) cn12291 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000009991 Cavia porcellus (guinea pig) 128400 Chlamidomonas reinhardtii (green alga) RP46404 Caenorhabditis remanei (nematode) 224895 Capitella spl (polychaete worm) DDB0232113 Dictyostelium discoideum (amoeba) DEHA2G08536g Debaryomyces Hansenii (yeast) 53232 Daphnia pulex (daphnia) ENSECAP00000018203 Equus caballus (horse) NP_416893.1 Escherichia coli K12 (bacteria) ENSGACP00000015490 Gymnopilus aculeatus (mushroom) ENSGALP00000018625 Gallus gallus (chicken) ENSP00000378364 Homo sapiens (human) ISCW015858-PA Ixodes scapularis (deer tick) KLLA0F17391g Kluyveromyces lactis (yeast) 143684 Lottia gigantea (owl limpet) 30285 Monocosta brevicollis (choanoflagellate) ENSMODP00000006316 Monodelphis domestica (gray opossum) ENSMMUP00000039682 Macaca mulatta (rhesus monkey) ENSMUSP00000023774 Mus musculus (house mouse) 164036 Nematostella vectensis (starlet anemone) XP_001600967.1 Nasonia vitripennis (wasp) ENSOANP00000004590 Ornithorynchus anatinus (platypus) ENSORLP00000019423 Oryzias latipes (japanese killifish) LOC_Os03g11010.1 Oryza sativa (asian rice) 26923 Ostreococcus tauri (green alga) PFE1185w Plasmodium falciparum (protozoal parasite) PHUM000934-PA Pediculus humanus (human body louse) PP01445 Pristionchus pacificus (nematode) 158431 Physcomitrella patens (moss) ENSPPYP00000005158 Pongo pygmaeus (orangutan) 79134 Phytophthora ramorum (sudden oak death pathogen) 137726 Phytophthora sojae (root rot pathogen) 278309 Populus trichocarpa (black cottonwood) ENSPTRP00000008446 Pan troglodytes (chimpanzee) PVX_080060 Plasmodium vivax (protozoal parasite) ENSRNOP00000026494 Rattus norvegicus (norway rat) 4745365 Sorghum bicolor (sorghum) YOL122C Saccharomyces cerevisiae (budding yeast) Smp_099850.3 Schistosoma mansoni (trematode parasite) SPAC27F1.08 Schizosaccharomyces pombe (fission yeast) XP_781841.2 Strongylocentrotus purpuratus (purple sea urchin) 20654 Trichoplax adhaerens (metazoa) XP_967521.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009880 Tetraodon nigroviridis (green spotted pufferfish) 9840 Thalassiosira pseudonana (marine diatom) ENSTRUP00000032407 Takifugu rubripes (pufferfish Takifugu) 3674.m00063 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000021232 Xenopus tropicalis (frog) YALI0D26818g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19021 NV18843 NV18844 NV17911 LH22843 ISCW015858 FBgn0067445 FBgn0216317 FBgn0197448 FBgn0067519 FBgn0170029 JGI_V11_53232 FBgn0077614 FBgn0150291 FBgn0133071 FBgn0130639 FBgn0107202 FBgn0095541 ACYPI010054 ACYPI009621 GB19114 GB15139 AGAP012464 PHUM047910 GLEAN_00399 GLEAN_14904
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	5151 w1118; P{lacW}Mvl97f 19886 y1 w67c23; P{EPgy2}MvlEY09165 743 w1118; Mvlm13/TM3, Sb1 P{35UZ}2 14419 y1 w67c23; ry506 P{SUPor-P}MvlKG02112
Harvard	- P{XP}Mvld01867 - PBac{PB}Mvlc01265 - PBac{PB}Mvlc01990
Kyoto	123528 w1118; P{RS3}MvlCB-5250-3 125713 w1118; P{RS5}Mvl5-HA-2861 104178 w*; P{GawB}MvlNP2375 / TM3, Sb1 Ser1
VDRC	v44000 w1118; P{GD3095}v44000
Genomic Clones ( 2 )
	BACR05I01 BACR20N14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 92 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24465 RE49741
Other clones	FI04486 MIP14640 MIP14740 MIP14840 MIP15667
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12867 GH03523 GH14215 GH24309 LD30223 LP06201 LP19489 RE14930 RE18080 RE18530 RE32304 RE41125 RE50254 RE54031 RE56979 RE57172 RH44926 RH64568 SD07840 SD14336
Other clones	37080 65595 70741 74336 98064 105379 120002 146187 173411 214219.57 214281.62 214371.77 214505.63 473624 524273 571135 575643 CK01.30D.C6 CK01.61A.E10 CK01.96C.B4 CK01.116A.H6 CK01.122A.H7 EK004706 EK010023 EK026843 EK093232 EK093601 EK147833 EK192447 EK220511 EK239860 EK248919 EK277755 EN00354 EN05059 EN16144 EN17459 EP07437 EP10435 EP14812 EP22341 FGH122H09 RE01118 RP004010449 RP004028396 RP004105182 RP004109533 RP004148216 RP004213166 RP004220833 RP004236060 RP004237646 RP004242711 RP004243323 RP004257990 RP004259744 RP004259895 RP004424179 RP004443337 RP004444259 RP004451356 RP004461262 RP004462312 RP004521615 RP004525784
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011672 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42490
Antibody Information
	polyclonal (Folwell et al., 2006)
Other Information
Discoverer
Etymology
	The gene name, coined by J. Chia, derives from the character Malvolio in Shakespeare's "Twelfth Night", who "taste(d) with distempered appetite". (Rodrigues et al., 1995)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mvl CG3671 (Gong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Isolated by homology to mammalian Nramp, Natural resistance-associated macrophage protein. Mutants exhibit altered gustatory behaviour and are defective in the neural pathway processing or discriminating gustatory information. (Cellier et al., 1995) The Mvl gene was identified in a screen for mutants that affect taste behaviour. Based on its mutant phenotype, expression pattern and similarity to the mammalian NRAMPs and a nitrate transporter in A.nidulans, the Mvl product may have a role in nitrite/nitrate transport. (Rodrigues et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079701 NM_169944 NM_001170197 RefSeq (Proteins) • NP_524425 NP_732584 NP_001163668 DDBJ / EMBL / GenBank • AA820638 AAA82593 AAF55839 AAL13772 AAN13847 AAS65187 AAV36881 ACZ94964 AQ073961 AW942706 AY058543 BH854525 BI364585 BT015996 CL705839 CZ467028 CZ468636 CZ468637 CZ472483 U23948 Entrez Gene - A searchable database of RefSeq genes. • 42490 UniProtKB/Swiss-Prot • P49283 UniProtKB/TrEMBL • A4V370 Q5U196
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Natural resistance-associated macrophage protein (IPR001046)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67461 DroID - A comprehensive database of gene and protein interactions. • FBgn0011672 DRSC - Results from RNAi screens. • FBgn0011672 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011672 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3671-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011672 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42490 InParanoid A subset of ortholog calls from InParanoid. • AGAP012464-PA Anopheles gambiae (mosquito) XP_001946266.1 Acyrthosiphon pisum (pea aphid) At5g67330.1 Arabidopsis thaliana (wall cress) 29076 Batrachochytrium dendrobatidis (chytrid fungus) 220855 Branchiostoma floridae (lancelet) 246766 Branchiostoma floridae (lancelet) ENSBTAP00000019133 Bos taurus (bovine) CAL0001616 Candida albicans (a form of yeast) CN03608 Caenorhabditis brenneri (small nematode) CBP29070 Caenorhabditis briggsae (nematode) CE41828 Caenorhabditis elegans (worm) ENSCAFP00000011707 Canis familiaris (dog) CAGL0A03476g Candida glabrata (haploid yeast) ENSCINP00000002598 Ciona intestinalis (sea squirt) JA14298 Caenorhabditis japonica (nematode) CML262C Cyanidioschyzon merolae (red alga) cn12291 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000009991 Cavia porcellus (guinea pig) 128400 Chlamidomonas reinhardtii (green alga) RP46404 Caenorhabditis remanei (nematode) 224895 Capitella spl (polychaete worm) DDB0232113 Dictyostelium discoideum (amoeba) DEHA2G08536g Debaryomyces Hansenii (yeast) 53232 Daphnia pulex (daphnia) ENSECAP00000018203 Equus caballus (horse) NP_416893.1 Escherichia coli K12 (bacteria) ENSGACP00000015490 Gymnopilus aculeatus (mushroom) ENSGALP00000018625 Gallus gallus (chicken) ENSP00000378364 Homo sapiens (human) ISCW015858-PA Ixodes scapularis (deer tick) KLLA0F17391g Kluyveromyces lactis (yeast) 143684 Lottia gigantea (owl limpet) 30285 Monocosta brevicollis (choanoflagellate) ENSMODP00000006316 Monodelphis domestica (gray opossum) ENSMMUP00000039682 Macaca mulatta (rhesus monkey) ENSMUSP00000023774 Mus musculus (house mouse) 164036 Nematostella vectensis (starlet anemone) XP_001600967.1 Nasonia vitripennis (wasp) ENSOANP00000004590 Ornithorynchus anatinus (platypus) ENSORLP00000019423 Oryzias latipes (japanese killifish) LOC_Os03g11010.1 Oryza sativa (asian rice) 26923 Ostreococcus tauri (green alga) PFE1185w Plasmodium falciparum (protozoal parasite) PHUM000934-PA Pediculus humanus (human body louse) PP01445 Pristionchus pacificus (nematode) 158431 Physcomitrella patens (moss) ENSPPYP00000005158 Pongo pygmaeus (orangutan) 79134 Phytophthora ramorum (sudden oak death pathogen) 137726 Phytophthora sojae (root rot pathogen) 278309 Populus trichocarpa (black cottonwood) ENSPTRP00000008446 Pan troglodytes (chimpanzee) PVX_080060 Plasmodium vivax (protozoal parasite) ENSRNOP00000026494 Rattus norvegicus (norway rat) 4745365 Sorghum bicolor (sorghum) YOL122C Saccharomyces cerevisiae (budding yeast) Smp_099850.3 Schistosoma mansoni (trematode parasite) SPAC27F1.08 Schizosaccharomyces pombe (fission yeast) XP_781841.2 Strongylocentrotus purpuratus (purple sea urchin) 20654 Trichoplax adhaerens (metazoa) XP_967521.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009880 Tetraodon nigroviridis (green spotted pufferfish) 9840 Thalassiosira pseudonana (marine diatom) ENSTRUP00000032407 Takifugu rubripes (pufferfish Takifugu) 3674.m00063 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000021232 Xenopus tropicalis (frog) YALI0D26818g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42490 modMine - Data generated by the modENCODE project. • FBgn0011672 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19021 NV18843 NV18844 NV17911 LH22843 ISCW015858 FBgn0067445 FBgn0216317 FBgn0197448 FBgn0067519 FBgn0170029 JGI_V11_53232 FBgn0077614 FBgn0150291 FBgn0133071 FBgn0130639 FBgn0107202 FBgn0095541 ACYPI010054 ACYPI009621 GB19114 GB15139 AGAP012464 PHUM047910 GLEAN_00399 GLEAN_14904
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG3671 (Keleman et al., 2009.8.5) dNRAMP (Rose et al., 2011) mvl (Shen and Cai, 2001, Nelson, 1999, D'Souza et al., 1999, Orgad et al., 1998, Reed et al., 1997, Cellier et al., 1995, Rodrigues et al., 1995) Mvl (Maruyama et al., 2011, Orgad et al., 1998, Folwell et al., 2006, Southon et al., 2008, Techau et al., 2007, Bushati et al., 2008, Bettedi et al., 2011) NRM2 (Mushegian et al., 1998)
Name Synonym	malvolio (Kimbrell and Beutler, 2001, Shen and Cai, 2001, Techau et al., 2007, Beckstead et al., 2007) Malvolio (Maruyama et al., 2008, Folwell et al., 2006, Southon et al., 2008, Bettedi et al., 2011)
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 3 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Bettedi et al., 2011, J. Exp. Biol. 214(6): 971--978 Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase. [FBrf0213129] Maruyama et al., 2011, PLoS ONE 6(6): e20901 Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head. [FBrf0214025] Rose et al., 2011, Cell Host Microbe 10(2): 97--104 Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and Mammalian hosts. [FBrf0214675] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...