Stop-codon suppression (UAG) postulated; FBrf0216884.
Gene model reviewed during 5.39
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.44
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
3.0 (northern blot)
486 (aa); 53 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mvl using the Feature Mapper tool.
Mvl transcripts are expressed in embryos, downregulated in first and second instar larvae, increase again in third instars and maintained in pupae and adults. Transcripts are first detected by in situ hybridization in germband extended embryos in cells surrounding the tracheal pits and in the procephalic lobe. Staining is observed along the posterior border of segment boundaries during germband retraction. Expression occurs in the amnioserosa and is observed as two rows of cells during dorsal closure. The most prominent neuronal expression is in the cells of the antenno-maxillary complex.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mvl in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Mvl CG3671
Isolated by homology to mammalian Nramp, Natural resistance-associated macrophage protein. Mutants exhibit altered gustatory behaviour and are defective in the neural pathway processing or discriminating gustatory information.
The gene name, coined by J. Chia, derives from the character Malvolio in Shakespeare's "Twelfth Night", who "taste(d) with distempered appetite".