FB2020_06, released Dec 22, 2020

Gene: Dmel\pav

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General Information
Symbol
Dmel\pav
Species
D. melanogaster
Name
pavarotti
Annotation Symbol
CG1258
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011692
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Snapshot
pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. [Date last reviewed: 2019-06-13]
Other Summaries
Also Known As

Pav-KLP, 2A12, Pavarotti-KLP, Pavarotti KLP, Mklp1

Key Links
Genomic Location
Cytogenetic map
64A10-64A11
Sequence location
3L:4,242,734..4,246,233 [+]
Recombination map

3-10

RefSeq locus
NT_037436 REGION:4242734..4246233
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (32 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:P92177
(assigned by UniProt )
(Norkett et al., 2020)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000648413
(assigned by GO_Central )
(Gaudet et al., 2011)
enables microtubule binding
inferred from biological aspect of ancestor with PANTHER:PTN000648413
(assigned by GO_Central )
(Gaudet et al., 2011)
enables microtubule motor activity
inferred from biological aspect of ancestor with PANTHER:PTN000648413
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (14 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in actomyosin contractile ring contraction
inferred from mutant phenotype
(Minestrini et al., 2003)
involved_in cell fate determination
inferred from mutant phenotype
(Jones et al., 2010)
involved_in maintenance of protein location in cell
inferred from mutant phenotype
(Dean et al., 2005)
involved_in microtubule bundle formation involved in mitotic spindle midzone assembly
inferred from mutant phenotype
(Goshima and Vale, 2005)
involved_in microtubule sliding
inferred from mutant phenotype
(assigned by UniProt )
(Norkett et al., 2020)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Dean et al., 2005, Somma et al., 2002)
involved_in mitotic spindle organization
inferred from mutant phenotype
(Goshima and Vale, 2005)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Jones et al., 2010)
inferred from genetic interaction with FLYBASE:arm; FB:FBgn0000117
(Jones et al., 2010)
inferred from genetic interaction with FLYBASE:tum; FB:FBgn0086356
(Jones et al., 2010)
involved_in negative regulation of neuron projection arborization
inferred from mutant phenotype
(assigned by UniProt )
(Norkett et al., 2020)
involved_in regulation of microtubule cytoskeleton organization
inferred from mutant phenotype
(Guerin and Kramer, 2009)
involved_in somatic muscle development
inferred from mutant phenotype
(Guerin and Kramer, 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in microtubule-based movement
inferred from biological aspect of ancestor with PANTHER:PTN000648413
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in mitotic spindle midzone assembly
inferred from biological aspect of ancestor with PANTHER:PTN001189481
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in peripheral nervous system development
traceable author statement
(Salzberg et al., 1994)
Cellular Component (13 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
located_in axoneme
inferred from direct assay
(Carmena et al., 1998)
part_of centralspindlin complex
inferred from direct assay
(Montembault et al., 2010)
located_in cleavage furrow
inferred from direct assay
(Sechi et al., 2017, Carmena et al., 1998)
located_in contractile ring
inferred from direct assay
(Carmena et al., 1998)
located_in female germline ring canal
inferred from direct assay
(Airoldi et al., 2011)
located_in kinetochore microtubule
inferred from direct assay
(Delcros et al., 2006)
located_in male germline ring canal
inferred from direct assay
(Carmena et al., 1998)
located_in midbody
inferred from direct assay
(Minestrini et al., 2003)
located_in mitotic spindle midzone
inferred from direct assay
(Derivery et al., 2015, Goshima and Vale, 2005)
located_in nucleus
inferred from direct assay
(Jones et al., 2010, Goshima and Vale, 2005, Minestrini et al., 2003)
located_in somatic ring canal
inferred from direct assay
(Airoldi et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of kinesin complex
inferred from biological aspect of ancestor with PANTHER:PTN000648413
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in microtubule
inferred from biological aspect of ancestor with PANTHER:PTN000648413
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001189478
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
KINESINS -
Kinesin superfamily proteins (KIFs) are microtubule motor proteins which use the hydrolysis of ATP to drive directional movement along microtubules. KIFs possess a well-conserved 360 residue globular head domain which binds and hydrolyses ATP and interacts with microtubules. Many KIFs homodimerize via coiled-coil interactions in the stalk region. KIFs bind cargo through their variable tail regions and are involved in transporting organelles, protein complexes, mRNAs and the movement of spindles and chromosomes during cell division. (Adapted from FBrf0219884).
Pathway (FlyBase)
Negative Regulators of Wnt-TCF Signaling Pathway -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Summary (Interactive Fly)

a kinesin motor protein - required both to establish the structure of the telophase spindle to provide a framework for assembly of the contractile ring and to mobilize mitotic regulator proteins - Pavarotti as an inhibitor of kinesin-1-driven microtubule sliding that regulates neurite outgrowth

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\pav for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
pav-RA
FBtr0073227
NM_057677
3207
887
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
pav-PA
FBpp0073083
100.7
887
9.75
NP_477025
AAF47868
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

886 (aa); 100 (kD observed)

(Adams et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pav using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | intense | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | intense | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
insulin secreting cell of pars intercerebralis
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain surface glia
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
egg chamber
(Minestrini et al., 2002)
nurse cell
• nucleus
(Minestrini et al., 2002)
ring canal
(Minestrini et al., 2002)
adult stage | female & oogenesis stage S7
oocyte
• nucleus
(Minestrini et al., 2002)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic cycle 16
organism
• midbody

Comment: telophase

(Somers and Saint, 2003)
organism
• spindle

Comment: metaphase

(Somers and Saint, 2003)
organism

Comment: anaphase

(Somers and Saint, 2003)
cell
• spindle

Comment: metaphase; expression assayed in cultured S2 cells

(Somers and Saint, 2003)
cell
• midbody

Comment: anaphase-telophase; expression assayed in cultured S2 cells

telophase; expression assayed in cultured S2 cells

(Somers and Saint, 2003, Somma et al., 2002)
cell

Comment: metaphase; expression assayed in cultured S2 cells

(Somma et al., 2002)
cell
• nucleus

Comment: interphase; expression assayed in cultured S2 cells

(Somers and Saint, 2003)
cell

Comment: expression assayed in cultured S2 cells; anaphase

(Somers and Saint, 2003)
adult stage
egg chamber
(Minestrini et al., 2002)
nurse cell
• nucleus
(Minestrini et al., 2002)
ring canal
(Minestrini et al., 2002)
adult stage | female & oogenesis stage S7
oocyte
• nucleus
(Minestrini et al., 2002)
Additional Descriptive Data

Expression of the protein is detected in the early egg chamber in the ring canals of the follicle cells and the oocyte and starting in stage 7 oocytes the protein isdetected in the oocyte nuclei. Lower levels of the protein are also detected in nurse cell nuclei. A pav-GFP protein confirms this localization although accumulation was more extensive and observed earlier in oogenesis, likely as a consequence of higher levels of expression mediated by the transgenic construct.

(Minestrini et al., 2002, Adams et al., 1998)

In S2 cells the pavprotein is found in a diffuse pattern throughout the cytoplasm during methaphase but concentrates at the central spindle microtubules in anaphase and telophase.

(Somma et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axoneme
inferred from direct assay
(Carmena et al., 1998)
part_of centralspindlin complex
inferred from direct assay
(Montembault et al., 2010)
located_in cleavage furrow
inferred from direct assay
(Sechi et al., 2017, Carmena et al., 1998)
located_in contractile ring
inferred from direct assay
(Carmena et al., 1998)
located_in female germline ring canal
inferred from direct assay
(Airoldi et al., 2011)
located_in kinetochore microtubule
inferred from direct assay
(Delcros et al., 2006)
located_in male germline ring canal
inferred from direct assay
(Carmena et al., 1998)
located_in midbody
inferred from direct assay
(Minestrini et al., 2003)
located_in mitotic spindle midzone
inferred from direct assay
(Derivery et al., 2015, Goshima and Vale, 2005)
located_in nucleus
inferred from direct assay
(Jones et al., 2010, Goshima and Vale, 2005, Minestrini et al., 2003)
located_in somatic ring canal
inferred from direct assay
(Airoldi et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\pav in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of pav
Transgenic constructs containing regulatory region of pav
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal (with Df(3L)GN50)
lethal | recessive
lethal - all die before end of embryonic stage | recessive
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4VP16.mat.αTub67C
Sterility
Allele
female fertile
female sterile, with Scer\GAL4VP16.mat.αTub67C
fertile, with Scer\GAL4VP16.mat.αTub67C
Other Phenotypes
Allele
cytokinesis defective | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
cytokinesis defective | embryonic stage | recessive
cytokinesis defective | somatic clone
decreased cell death | larval stage | somatic clone
decreased occurrence of cell division | embryonic stage
decreased occurrence of cell division | embryonic stage | somatic clone
increased cell size | embryonic stage
increased cell size | larval stage | somatic clone
locomotor behavior defective | adult stage, with Scer\GAL4Mef2.PR
meiotic cell cycle defective | dominant
mitotic cell cycle defective
neuroanatomy defective | embryonic stage | recessive
neuroanatomy defective | larval stage
size defective | embryonic stage | somatic clone
some die during embryonic stage | recessive
visible, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
abdominal ventral denticle belt | embryonic stage
abdominal ventral denticle belt | embryonic stage (with Df(3L)GN24)
actin filament & nurse cell, with Scer\GAL4VP16.mat.αTub67C
centrosome | embryonic cycle 16
commissure
egg, with Scer\GAL4VP16.mat.αTub67C
egg chamber, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval somatic muscle
embryonic epidermis
ganglion mother cell | larval stage
larval neuroblast | larval stage
longitudinal connective
mesothoracic tergum, with Scer\GAL4pnr-MD237
microtubule
mitotic domain 1 | embryonic cycle 16
mushroom body & axon | somatic clone
neuron & peripheral nervous system
neuron | embryonic stage
nucleus
nucleus (with Df(3L)GN50)
nurse cell, with Scer\GAL4VP16.mat.αTub67C
nurse cell & microtubule, with Scer\GAL4VP16.mat.αTub67C
oocyte, with Scer\GAL4VP16.mat.αTub67C
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
ring canal, with Scer\GAL4VP16.mat.αTub67C
spindle | embryonic cycle 16
ventral nerve cord | embryonic stage
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KIF23
14 of 15
Yes
Yes
Hsap\KIF20A
3 of 15
No
No
Hsap\KIF20B
3 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kif23
12 of 15
Yes
Yes
Mmus\Kif20a
3 of 15
No
No
Mmus\Kif20b
3 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Kif23
9 of 13
Yes
Yes
Rnor\Kif20a
2 of 13
No
No
Rnor\Kif20b
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\kif23
9 of 12
Yes
Yes
Xtro\kif20a
2 of 12
No
No
Xtro\kif20b
1 of 12
No
Yes
Xtro\LOC100489788
1 of 12
No
No
Danio rerio (Zebrafish) (5)
Drer\kif23
14 of 15
Yes
Yes
Drer\kif20ba
3 of 15
No
No
Drer\kif20a
2 of 15
No
No
Drer\kif20bb
2 of 15
No
No
Drer\zgc:56231
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\zen-4
14 of 15
Yes
Yes
Cele\klp-10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\klp9
7 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919025L )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010057
Drosophila simulans
Dsim\pav
Drosophila sechellia
Dsec\GM14638
Drosophila erecta
Dere\pav
Drosophila yakuba
Dyak\pav
Drosophila ananassae
Dana\GF10567
Drosophila pseudoobscura pseudoobscura
Dpse\GA11700
Drosophila persimilis
Dper\GL21444
Drosophila persimilis
Dper\GL12840
Drosophila persimilis
Dper\GL13777
Drosophila willistoni
Dwil\GK10551
Drosophila virilis
Dvir\GJ12838
Drosophila mojavensis
Dmoj\GI16586
Drosophila grimshawi
Dgri\GH15541
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915003R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024961
Musca domestica
House fly
Mdoa\17020454
Glossina morsitans
Tsetse fly
Gmor\GMOY006867
Glossina morsitans
Tsetse fly
Gmor\GMOY001727
Glossina morsitans
Tsetse fly
Gmor\GMOY004109
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08445
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02598
Mayetiola destructor
Hessian fly
Mdes\Mdes009955
Mayetiola destructor
Hessian fly
Mdes\Mdes009093
Mayetiola destructor
Hessian fly
Mdes\Mdes000705
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002714
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001542
Anopheles darlingi
American malaria mosquito
Adar\ADAC004893
Anopheles darlingi
American malaria mosquito
Adar\ADAC004902
Anopheles gambiae
Malaria mosquito
Agam\AGAP007706
Anopheles gambiae
Malaria mosquito
Agam\AGAP007709
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017948
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017655
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01GI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007794
Bombyx mori
Silkmoth
Bmor\BGIBMGA011193
Danaus plexippus
Monarch butterfly
Dple\DPOGS208086-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203107-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005565
Heliconius melpomene
Postman butterfly
Hmel\HMEL006228
Apis florea
Little honeybee
Aflo\2386681060
Apis florea
Little honeybee
Aflo\2604745892
Apis florea
Little honeybee
Aflo\2147590323
Apis mellifera
Western honey bee
Amel\GB54127
Apis mellifera
Western honey bee
Amel\kinesin-6B
Apis mellifera
Western honey bee
Amel\kinesin-6A
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19704
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11098
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11106
Bombus terrestris
Buff-tailed bumblebee
Bter\15208930
Bombus terrestris
Buff-tailed bumblebee
Bter\15206119
Bombus terrestris
Buff-tailed bumblebee
Bter\15208947
Linepithema humile
Argentine ant
Lhum\LH15357
Linepithema humile
Argentine ant
Lhum\LH18687
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0010d6
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001176
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0031b8
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012364
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017954
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05930
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15503
Tribolium castaneum
Red flour beetle
Tcas\pav2
Pediculus humanus
Human body louse
Phum\PHUM505210
Pediculus humanus
Human body louse
Phum\PHUM193530
Rhodnius prolixus
Kissing bug
Rpro\RPRC010446
Rhodnius prolixus
Kissing bug
Rpro\RPRC008677
Cimex lectularius
Bed bug
Clec\CLEC003698
Cimex lectularius
Bed bug
Clec\CLEC013069
Cimex lectularius
Bed bug
Clec\CLEC006555
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010128
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006157
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11968
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11655
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01EQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008504
Strigamia maritima
European centipede
Smar\SMAR003718
Ixodes scapularis
Black-legged tick
Isca\ISCW015412
Ixodes scapularis
Black-legged tick
Isca\ISCW003234
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65237.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83444.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57466.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79904.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57467.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur29g00350
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g05550
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g02090
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305721
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_39704
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G024C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kcnh7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kif23
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Krp110
Ciona intestinalis
Vase tunicate
Cint\LOC100181038
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003537
Gallus gallus
Domestic chicken
Ggal\KCNH7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000505
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027043
Gallus gallus
Domestic chicken
Ggal\KIF23
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (26)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
sub
5 of 10
cana
2 of 10
CG32318
2 of 10
cmet
2 of 10
cos
2 of 10
Khc-73
2 of 10
Khc
2 of 10
Kif3C
2 of 10
Kif19A
2 of 10
Klp3A
2 of 10
Klp10A
2 of 10
Klp31E
2 of 10
Klp54D
2 of 10
Klp59C
2 of 10
Klp59D
2 of 10
Klp61F
2 of 10
Klp64D
2 of 10
Klp67A
2 of 10
Klp68D
2 of 10
Klp98A
2 of 10
ncd
2 of 10
neb
2 of 10
nod
2 of 10
unc-104
2 of 10
CG5004
1 of 10
CG14535
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KIF23; kinesin family member 23
    14 of 15
    605064
        KIF20A; kinesin family member 20A
        3 of 15
        605664
            KIF20B; kinesin family member 20B
            3 of 15
            605498
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                pav
                proximity-dependent biotin identification, Identification by mass spectrometry, western blot, proximity ligation assay, fluorescence microscopy, cosedimentation through density gradient, molecular weight
                (Mannix et al., 2019, Sommi et al., 2010)
                pav - ALiX
                anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry, pull down, autoradiography
                (Lie-Jensen et al., 2019)
                pav - AP-2μ
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - Arf51F
                pull down, western blot, two hybrid
                (Dyer et al., 2007)
                pav - BicD
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - CG32344
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - CG43333
                proximity-dependent biotin identification, Identification by mass spectrometry
                (Mannix et al., 2019)
                pav - CG8939
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - Dgp-1
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - Lkb1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                pav - Map205
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - Srp72
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - eIF2β
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - feo
                pull down, autoradiography
                (Bassi et al., 2013)
                pav - foxo
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                pav - gig
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                pav - l(1)G0020
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - neb
                pull down, autoradiography
                (Bassi et al., 2013)
                pav - nesd
                pull down, autoradiography, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Montembault et al., 2010)
                pav - pit
                experimental knowledge based
                (Guruharsha et al., 2011)
                pav - sau
                pull down, western blot
                (Sechi et al., 2014)
                pav - scra
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (D'Avino et al., 2008)
                pav - sima
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                pav - sti
                pull down, autoradiography, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
                (Bassi et al., 2013)
                pav - tum
                proximity-dependent biotin identification, Identification by mass spectrometry, two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, anti bait coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy
                (Lie-Jensen et al., 2019, Mannix et al., 2019, Guruharsha et al., 2011, Ebrahimi et al., 2010, Jones et al., 2010, Montembault et al., 2010, Somers and Saint, 2003)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                pav|tum
                enhanceable
                wg
                (Jones et al., 2010)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                arm
                suppressible
                pav
                (Jones et al., 2010)
                nesd
                suppressible
                pav
                (Montembault et al., 2010)
                nesd
                enhanceable
                pav
                (Montembault et al., 2010)
                pbl
                enhanceable
                pav
                (Gregory et al., 2007)
                smo
                enhanceable
                pav
                (Collins, 2005.7.7, Collins and Cohen, 2005)
                smo
                suppressible
                pav
                (Collins, 2005.7.7, Collins and Cohen, 2005)
                tum
                enhanceable
                pav
                (Jones et al., 2010)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Negative Regulators of Wnt-TCF Signaling Pathway -
                Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
                Metabolic Pathways
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3L
                Recombination map

                3-10

                Cytogenetic map
                64A10-64A11
                Sequence location
                3L:4,242,734..4,246,233 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                64A10-64A11
                Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                64B2-64B7
                (Adams, 1998.3.25)
                64B-64B
                (determined by in situ hybridisation)
                (Szeged Stock Center, 1998-, Deak et al., 1997, Salzberg et al., 1997)
                64B2-64B14
                (determined by in situ hybridisation)
                (Salzberg et al., 1994)
                Experimentally Determined Recombination Data
                Location

                3-10

                (FlyBase, 2016)

                3-9.2

                (Comeron et al., 2012)

                3-

                (Collins and Cohen, 2005)

                3-18--20

                (Salzberg et al., 1994)
                Left of (cM)
                (Collins and Cohen, 2005)
                Right of (cM)
                (Collins and Cohen, 2005)
                Notes
                Stocks and Reagents
                Stocks (19)
                Genomic Clones (17)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (75)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Lie-Jensen et al., 2019, Sommi et al., 2010, Adams et al., 1998)
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: pav CG1258

                (Gabrielian, 1999.11)
                Source for database merge of

                Source for merge of: pav Mklp1

                (FlyBase, 1996-)
                Additional comments

                Source for merge of pav Mklp1 was sequence comparison ( date:000202 ).

                (FlyBase, 1996-)

                FlyBase Curator comment: Despite several pav synonyms containing the characters "2A12", the protein product of pav is NOT the antigen recognized by the monoclonal 2A12 antibody.

                (FlyBase, 1992-)
                Other Comments

                pav regulates microtubule organisation during myogenesis.

                (Guerin and Kramer, 2009)

                RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape and cytokinesis failure when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

                (Goshima et al., 2007)

                dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

                (Echard et al., 2004)

                RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.

                (Eggert et al., 2004)

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)

                RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells.

                (Kiger et al., 2003)

                Five EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.

                (Hummel et al., 1999)

                Candidate gene for quantitative trait (QTL) locus determining bristle number.

                (Nuzhdin et al., 1999)

                pav is required to organise the central spindle and contractile ring for cytokinesis.

                (Adams et al., 1998)

                Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

                (Schmid and Tautz, 1997)

                Mutation in pav affects cell division in the neuronal lineage.

                (Salzberg et al., 1994)

                pav is required for PNS development in the embryo.

                (Salzberg et al., 1994)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 47 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (40)
                Reported As
                Symbol Synonym
                0934/13
                (Deak et al., 1997)
                0973/08
                (Deak et al., 1997)
                2A12
                (Wang et al., 2012, Tiklova et al., 2010, Franch-Marro et al., 2006, Jiang and Crews, 2006, Krause et al., 2006, Luschnig et al., 2006, Tonning et al., 2006, Araujo et al., 2005, Wu and Beitel, 2004, Tautz and Schmid, 1998)
                2A12MEL
                (Schmid and Tautz, 1998)
                CG1258
                (Verma and Maresca, 2019, Çiçek et al., 2016, Chittaranjan et al., 2015, Hosono et al., 2015, Moutinho-Pereira et al., 2013, Schertel et al., 2013, Ni et al., 2011.7.19, Haglund et al., 2010, Montembault et al., 2010, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Derré et al., 2007, Goshima et al., 2007, Goldstein and Gunawardena, 2000)
                DmKLP1/pav
                (Endow, 1999)
                DmMKLP1
                (Schmid and Tautz, 1998)
                DmPAV
                (Dagenbach and Endow, 2004)
                DmPav
                (Hirokawa, 2012, Dagenbach and Endow, 2004)
                KIF 23
                (Miki et al., 2001)
                KIF23
                (Hirokawa, 2012.11.20)
                MKLP1
                (Aguilar-Aragon et al., 2020, Verma and Maresca, 2019)
                Mklp1
                (Schmid and Tautz, 1997)
                PAV
                (Moshkin et al., 2009, D'Avino et al., 2006, D'Avino et al., 2005, Jang et al., 2005)
                PAV-KLP
                (Riparbelli and Callaini, 2005, Adams et al., 2001, Adams, 1998.3.25)
                PAV-MKLP
                (Field et al., 1999)
                PAV/KLP
                (Kwon and Scholey, 2004)
                Pav
                (Nakamura et al., 2020, Norkett et al., 2020, Costa and Ohkura, 2019, Lie-Jensen et al., 2019, Roubinet et al., 2017, Sechi et al., 2017, McLaughlin et al., 2016, Afonso et al., 2014, Sechi et al., 2014, McLean and Cooley, 2013, McLean and Cooley, 2013, Takeda et al., 2013, Yadlapalli and Yamashita, 2013, Crest et al., 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Hirokawa, 2012.11.20, Szafer-Glusman et al., 2011, Ong and Tan, 2010, Coumailleau et al., 2009, Vale et al., 2009, Goshima et al., 2007, Gwack et al., 2007, Jones and Bejsovec, 2007, Bokel et al., 2006, Resnick et al., 2006, Goshima and Vale, 2005, Miki et al., 2005, Miki et al., 2001)
                Pav KLP
                (Airoldi and Cooley, 2007)
                Pav-KLP
                (McLaughlin et al., 2016, Airoldi et al., 2011, Riparbelli and Callaini, 2011, Ebrahimi et al., 2010, Sommi et al., 2010, D'Avino et al., 2008, Goshima et al., 2007, Gregory et al., 2007, Colombie et al., 2006, Pearson et al., 2006, Riparbelli et al., 2005, Zavortink et al., 2005, Inoue et al., 2004, Barbosa et al., 2003, Minestrini et al., 2003, Riparbelli and Callaini, 2003, Minestrini et al., 2002, Donaldson et al., 2001, Gonzalez and Bornens, 2000, Carmena et al., 1998)
                Pav-Klp
                (Haglund et al., 2010)
                Pav-klp
                (Prigent et al., 2005)
                PavKLP
                (Tao and Scholey, 2010)
                anon-EST:fe2A12
                anon2A12
                (Schmid, 1997.5.30)
                group D
                (Collins, 2005.7.7, Collins and Cohen, 2005)
                kinesin-6
                (Tao et al., 2016)
                pav
                (Witte et al., 2020, Finegan et al., 2019, Hughes and Simmonds, 2019, Mannix et al., 2019, Parkhurst, 2019.4.17, Rotelli et al., 2019, Hao et al., 2018, Transgenic RNAi Project members, 2017-, Tao et al., 2016, Chittaranjan et al., 2015, Dequéant et al., 2015, Fischer et al., 2015, Kitazawa et al., 2014, Matsuoka et al., 2014, Johnson et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Unhavaithaya et al., 2013, Bateman et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Joyce et al., 2012, Korenjak et al., 2012, Lesch and Page, 2012, Friedman et al., 2011, Neumüller et al., 2011, Szafer-Glusman et al., 2011, Cabernard et al., 2010, Ebrahimi et al., 2010, Jones et al., 2010, Montembault et al., 2010, Müller et al., 2010, Ong et al., 2010, Guerin and Kramer, 2009, Christensen et al., 2008.7.11, Somma et al., 2008, Tögel et al., 2008, Christensen et al., 2007.10.29, Derré et al., 2007, Dyer et al., 2007, Akashi et al., 2006, D'Avino et al., 2006, Mukai et al., 2006, Zavortink et al., 2005)
                pav-KLP
                (Montembault et al., 2010, Delcros et al., 2006)
                pav-Klp
                (Riparbelli et al., 2002)
                Name Synonyms
                Kinesin-6
                (Vale et al., 2009)
                Kinesin6
                (Kollmar, 2015.9.15)
                Mitotic kinesin-like protein 1
                (Schmid and Tautz, 1998)
                Pavarotti
                (Lie-Jensen et al., 2019, Verma and Maresca, 2019, McLaughlin et al., 2016, Taniguchi et al., 2014, Moutinho-Pereira et al., 2013, Takeda et al., 2013, Crest et al., 2012, Giansanti and Fuller, 2012, Giansanti et al., 2012, Hirokawa, 2012.11.20, Cheng et al., 2011, Szafer-Glusman et al., 2011, Castoreno et al., 2010, Inaba et al., 2010, Montembault et al., 2010, Coumailleau et al., 2009, Guerin et al., 2008, Prokopenko and Chia, 2008, Szafer-Glusman et al., 2008, D'Avino et al., 2007, Jones and Bejsovec, 2007, Nurminsky, 2007, Prokopenko and Chia, 2007, Bokel et al., 2006, Bokel et al., 2006, Foglietti et al., 2006, Gatt and Glover, 2006, D'Avino et al., 2005, Goshima and Vale, 2005, Zavortink et al., 2005)
                Pavarotti KLP
                (Airoldi and Cooley, 2007, Airoldi and Cooley, 2006, Airoldi and Cooley, 2005)
                Pavarotti kinesin-like protein
                (Airoldi et al., 2011)
                Pavarotti-KLP
                (Airoldi and Cooley, 2008, Delcros et al., 2006, Resnick et al., 2006, Prigent et al., 2005)
                Pavarroti
                (Vendra et al., 2007)
                anon-fast-evolving-2A12
                kinesin-6
                (Tao and Scholey, 2010)
                pavarotti
                (Das et al., 2016, Dequéant et al., 2015, Debruhl et al., 2013, Unhavaithaya et al., 2013, Yadlapalli and Yamashita, 2013, Ahmad et al., 2012, Lesch and Page, 2012, Meyer et al., 2011, Riparbelli and Callaini, 2011, Jones et al., 2010, Guerin and Kramer, 2009, Somma et al., 2008, Tögel et al., 2008, Georlette et al., 2007, Gregory et al., 2007, Tadros et al., 2007, Mukai et al., 2006, Dean et al., 2005, Gatt et al., 2005, Riparbelli and Callaini, 2005, Riparbelli et al., 2005, Bellotto et al., 2002, Salzberg et al., 1994)
                Secondary FlyBase IDs
                • FBgn0022345
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (256)