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Gene Dmel\Snr1

General Information
Symbol	Dmel\Snr1	Species	D. melanogaster
Name	Snf5-related 1	Annotation symbol	CG1064
Feature type	protein_coding_gene	FlyBase ID	FBgn0011715
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	BAP45, snr
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	83A4-83A4	Sequence location	3R:1,296,648..1,298,476 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Snf5-related 1 is referred to in FlyBase by the symbol Dmel\Snr1 (CG1064, FBgn0011715). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: SET domain binding; protein binding. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing margin morphogenesis; dendrite morphogenesis; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; muscle organ development; positive regulation of transcription, DNA-dependent; epidermis development; negative regulation of cell proliferation; dendrite guidance. 23 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; adult antennal lobe projection neuron DL1 adPN; wing; tergite; wing vein; wing vein L2. It has one annotated transcript and one annotated polypeptide. Protein features are: SNF5/SMARCB1/INI1; SWI/SNF chromatin-remodeling complex, component hSNF5/Ini1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625112_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Snr1. Gene sequence location is 3R:1296648..1298476.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A4-83A4   Limits computationally determined from genome sequence between P{EP}EP974 and P{PZ}Snr101319&P{PZ}Itp-r83A05616
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83A5-83A6     (Dingwall, 1995.6.6) 83A5-83A6   (determined by in situ hybridisation)   (Spradling et al., 1999) 83A5-83A6   (determined by in situ hybridisation)   (Dingwall et al., 1995) 83A5-83A6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Dingwall, 1995.6.6)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Snr1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Snr1-RA FBtr0078682  NM_169055   1335   370
Additional Transcript Data & Comments
Reported size (kB)	1.4 (northern blot) (Dingwall et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Snr1-PA   FBpp0078331   41.9   370   4.91     NP_730935   AAF52024
Additional Polypeptide Data & Comments
Reported size (kDa)	370 (aa); 43 (kD observed); 43 (kD predicted) (Dingwall et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SNF5/SMARCB1/INI1 (IPR006939) SWI/SNF chromatin-remodeling complex, component hSNF5/Ini1 (IPR017393)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202023   AA390482   AA439789   AA538640   AA538674   AA539772   AA540401   AA540547   AA696784   AA803920   AA816887   AA949661   AE014297 AAF52024   AI107416   AI109494   AI402144   AI512685   AI543017   AQ026168   AY070501 AAL47972   BI142213   BI169596   BI236365   BI356360   BI370970   BI375981   BI635459   BI637898   CO190774   CO191088   CO280067   CO281252   CO289998   CO317835   CO325042   CO333353   EC058118   EC063426   EC068511   EC078159   EC230749   EC237883   EC251240   EV589446   FE863497   FE863574   FE863628   FE863713   FE863882   FE863960   U28485 AAC77830
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24090
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- pupal stage     (Dingwall et al., 1995) embryonic stage -- adult stage     (Zraly et al., 2003) adult stage | female     (Dingwall et al., 1995)   unfertilized egg   (Dingwall et al., 1995)
Additional Descriptive Data
	Nothern blotting with Snr1 specific riboprobes confirmed that the transcript can be detected at all stages of development. A transient increase in message was observed late in third instar larvae and in pupae corresponding to the time of rising titers of ecdysone hormone. In contrast to previous experiments expression was detected in adult males. (Zraly et al., 2003) Snr1 transcripts are expressed maximally in unfertilized eggs and early embryos, indicating maternal contributions. Levels drop steadily during embryogenesis with a dramatic drop at 16hrs. Low levels of Snr1 transcripts are observed in larvae, pupae, and adult females. The temporal pattern of Snr1 transcription is very similar to that of brm. (Dingwall et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 3   organism   • nucleus (Zraly et al., 2004) Comment:punctate within nuclei in a restricted region near the posterior blastoderm stage   organism   • nucleus (Zraly et al., 2004) embryonic stage 5   organism   • nucleus (Zraly et al., 2004) third instar larval stage   eye disc   (Zraly et al., 2003) wing disc | restricted   (Zraly et al., 2003) embryonic/larval salivary gland   • nucleus (Zraly et al., 2003) embryonic/larval optic lobe | restricted   (Zraly et al., 2003) germarium region 2 & germarium region 3   (Zraly et al., 2003) ventral thoracic disc | restricted   (Zraly et al., 2003) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Dingwall et al., 1995) embryonic stage -- pupal stage     (Dingwall et al., 1995) embryonic stage 13 -- 17   embryonic brain   (Dingwall et al., 1995) presumptive embryonic/larval central nervous system   (Dingwall et al., 1995) larval stage   imaginal disc   (Dingwall et al., 1995) embryonic/larval salivary gland   (Dingwall et al., 1995) adult stage | female     (Dingwall et al., 1995)
Additional Descriptive Data
	In the larval CNS expression of Snr1 protein is restricted to a subset of cells in the optic lobe. The protein is also restricted to subsets of cells in the leg and wing discs with low or undetectable expression in some discs. The Snr1 protein is detected at relatively high levels in developing eye discs both anterior and posterior to the morphogenetic furrow. The protein is detected in a punctate pattern within the nuclei of salivary gland cells. Staining is also observed in germarium regions 2 and 3 in the ovariole. A few cells of the somatic follicular sheath and nurse cell nuclei and the developing oocyte also express low levels of the Snr1 protein. (Zraly et al., 2003) Fluorescent confocal imaging of Snr1 localization in similarly staged embryos showed that the protein was tightly associated with chromatin in the vast majority of nuclei. Occasionally, Snr1 appeared more diffuse in the cytosol and closer examination revealed that the majority of chromosomes were in metaphase. (Zraly et al., 2004) Snr1 protein is detected at its highest level in early embryos. Low levels are found in larvae, pupae, and adult females. Snr1 protein is found in all nuclei of the embryo through germ band extension. After germ band retraction it is located almost exclusively in the brain and CNS. Snr1 protein is detected in salivary glands and imaginal discs in larvae (Dingwall et al., 1995)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
brahma complex inferred from direct assay (Kal et al., 2000, Marenda et al., 2003) nucleus inferred from direct assay (Mohrmann et al., 2004, Dingwall et al., 1995)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary    602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (618.9) Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary  (602.2) Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary    602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary    602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary    602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary  602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary    602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    618.9 Larval Midgut    151.8 Larval Hindgut    158.4 Larval Malpighian Tubules    192 Larval Fat Body    137.8 Larval Salivary Gland    223.6 Larval Trachea    347.575 Larval Carcass    202.325 Adult Head    170.1 Adult Eye    267.2 Adult Brain    251.2 Adult Thoracic-Abdominal Ganglion    242.1 Adult Crop    201.6 Adult Midgut    158.1 Adult Hindgut    152.1 Adult Malpighian Tubules    149.1 Adult Fat Body    84.3 Adult Salivary Gland    173 Adult Heart    152.4 Adult VirginFemale Spermatheca    137.9 Adult InseminatedFemale Spermatheca    168.2 Adult Ovary    602.2 Adult Testis    86.8 Adult Male Accessory Gland    263.7 Adult Carcass    120.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    170.1   NA  Eye    267.2   NA  Brain    251.2   618.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    242.1   NA  Crop    201.6   151.8  Midgut    158.1   158.4  Hindgut    152.1   192  Malpighian Tubules    149.1   137.8  Fat Body    84.3   223.6  Salivary Gland    no informative data   NA  Heart    152.4   347.575  Trachea    NA   NA  VirginFemale Spermatheca    137.9   NA  InseminatedFemale Spermatheca    168.2   NA  Ovary    602.2   NA  Testis    86.8   NA  Male Accessory Gland    263.7   202.325  Carcass    120.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    55 central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    74 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (55) central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering  (28) carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female  (74) ovary, mated 4-day female  (55) testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    55 central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    74 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    55 central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    74 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    55 central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    74 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (55) central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering  28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female  (74) ovary, mated 4-day female  (55) testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    55 central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    74 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    55 central nervous system, pupae P8    16 head, virgin 1-day female    7 head, virgin 4-day female    9 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    12 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    22 carcass, larvae L3 wandering    28 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    74 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    141 embryo 02-04hr    215 embryo 04-06hr    187 embryo 06-08hr    173 embryo 08-10hr    144 embryo 10-12hr    118 embryo 12-14hr    68 embryo 14-16hr    87 embryo 16-18hr    58 embryo 18-20hr    38 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    50 white prepupae 24hr    61 pupae 2d postWPP    30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day    43 adult female 05day    64 adult female 30day    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (141) embryo 02-04hr  (215) embryo 04-06hr  (187) embryo 06-08hr  (173) embryo 08-10hr  (144) embryo 10-12hr  (118) embryo 12-14hr  (68) embryo 14-16hr  (87) embryo 16-18hr  (58) embryo 18-20hr  (38) embryo 20-22hr  (58) embryo 22-24hr  (52) larva L1  (30) larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2  26 larva L3 puffstage 3-6  (32) larva L3 puffstage 7-9  (39) white prepupae new  (35) white prepupae 12hr  (50) white prepupae 24hr  (61) pupae 2d postWPP  (30) pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day  (43) adult female 05day  (64) adult female 30day  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (141) embryo 02-04hr  (215) embryo 04-06hr  (187) embryo 06-08hr  (173) embryo 08-10hr  (144) embryo 10-12hr  (118) embryo 12-14hr    68 embryo 14-16hr    87 embryo 16-18hr    58 embryo 18-20hr    38 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    50 white prepupae 24hr    61 pupae 2d postWPP    30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day    43 adult female 05day    64 adult female 30day    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    141 embryo 02-04hr    215 embryo 04-06hr    187 embryo 06-08hr    173 embryo 08-10hr    144 embryo 10-12hr    118 embryo 12-14hr    68 embryo 14-16hr    87 embryo 16-18hr    58 embryo 18-20hr    38 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    50 white prepupae 24hr    61 pupae 2d postWPP    30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day    43 adult female 05day    64 adult female 30day    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    141 embryo 02-04hr    215 embryo 04-06hr    187 embryo 06-08hr    173 embryo 08-10hr    144 embryo 10-12hr    118 embryo 12-14hr    68 embryo 14-16hr    87 embryo 16-18hr    58 embryo 18-20hr    38 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    50 white prepupae 24hr    61 pupae 2d postWPP    30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day    43 adult female 05day    64 adult female 30day    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (141) embryo 02-04hr  (215) embryo 04-06hr  (187) embryo 06-08hr  (173) embryo 08-10hr  (144) embryo 10-12hr  (118) embryo 12-14hr  (68) embryo 14-16hr  (87) embryo 16-18hr  (58) embryo 18-20hr  (38) embryo 20-22hr  (58) embryo 22-24hr  (52) larva L1  30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2  26 larva L3 puffstage 3-6  32 larva L3 puffstage 7-9  (39) white prepupae new  (35) white prepupae 12hr  (50) white prepupae 24hr  (61) pupae 2d postWPP  30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day  (43) adult female 05day  (64) adult female 30day  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  141 embryo 02-04hr  (215) embryo 04-06hr  (187) embryo 06-08hr  (173) embryo 08-10hr  (144) embryo 10-12hr  118 embryo 12-14hr    68 embryo 14-16hr    87 embryo 16-18hr    58 embryo 18-20hr    38 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    50 white prepupae 24hr    61 pupae 2d postWPP    30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day    43 adult female 05day    64 adult female 30day    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    141 embryo 02-04hr    215 embryo 04-06hr    187 embryo 06-08hr    173 embryo 08-10hr    144 embryo 10-12hr    118 embryo 12-14hr    68 embryo 14-16hr    87 embryo 16-18hr    58 embryo 18-20hr    38 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    30 larva L2    24 larva L3 12hr old    18 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    35 white prepupae 12hr    50 white prepupae 24hr    61 pupae 2d postWPP    30 pupae 3d postWPP    17 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    16 adult male 30day    18 adult female 01day    43 adult female 05day    64 adult female 30day    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    69 Schneider line 2 Sg4    66 embryonic 1182-4H    43 embryonic GM2    27 embryonic Kc167    28 embryonic S1    69 embryonic S3    35 leg disc CME L1    57 wing disc CME-W2    29 wing disc ML-DmD8    49 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    109 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    63 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    29 ovary fGS/OSS    67 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (69) Schneider line 2 Sg4  (66) embryonic 1182-4H  (43) embryonic GM2  (27) embryonic Kc167  (28) embryonic S1  (69) embryonic S3  (35) leg disc CME L1  (57) wing disc CME-W2  (29) wing disc ML-DmD8  (49) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (43) wing disc ML-DmD21  (109) wing disc ML-DmD32  (57) haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (63) mixed discs ML-DmD4-c1  (55) CNS ML-DmBG1-c1  (45) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  (29) ovary fGS/OSS  (67) ovary OSC  (34) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    69 Schneider line 2 Sg4    66 embryonic 1182-4H    43 embryonic GM2    27 embryonic Kc167    28 embryonic S1    69 embryonic S3    35 leg disc CME L1    57 wing disc CME-W2    29 wing disc ML-DmD8    49 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    43 wing disc ML-DmD21  (109) wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    63 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    29 ovary fGS/OSS    67 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    69 Schneider line 2 Sg4    66 embryonic 1182-4H    43 embryonic GM2    27 embryonic Kc167    28 embryonic S1    69 embryonic S3    35 leg disc CME L1    57 wing disc CME-W2    29 wing disc ML-DmD8    49 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    109 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    63 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    29 ovary fGS/OSS    67 ovary OSC    34 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    69 Schneider line 2 Sg4    66 embryonic 1182-4H    43 embryonic GM2    27 embryonic Kc167    28 embryonic S1    69 embryonic S3    35 leg disc CME L1    57 wing disc CME-W2    29 wing disc ML-DmD8    49 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    109 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    63 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    29 ovary fGS/OSS    67 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (69) Schneider line 2 Sg4  (66) embryonic 1182-4H  (43) embryonic GM2  27 embryonic Kc167  28 embryonic S1  (69) embryonic S3  (35) leg disc CME L1  (57) wing disc CME-W2  29 wing disc ML-DmD8  (49) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (43) wing disc ML-DmD21  (109) wing disc ML-DmD32  (57) haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (63) mixed discs ML-DmD4-c1  (55) CNS ML-DmBG1-c1  (45) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  29 ovary fGS/OSS  (67) ovary OSC  (34) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    69 Schneider line 2 Sg4    66 embryonic 1182-4H    43 embryonic GM2    27 embryonic Kc167    28 embryonic S1    69 embryonic S3    35 leg disc CME L1    57 wing disc CME-W2    29 wing disc ML-DmD8    49 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    43 wing disc ML-DmD21  109 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    63 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    29 ovary fGS/OSS    67 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    69 Schneider line 2 Sg4    66 embryonic 1182-4H    43 embryonic GM2    27 embryonic Kc167    28 embryonic S1    69 embryonic S3    35 leg disc CME L1    57 wing disc CME-W2    29 wing disc ML-DmD8    49 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    43 wing disc ML-DmD21    109 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    63 mixed discs ML-DmD4-c1    55 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    29 ovary fGS/OSS    67 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (32) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (45) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (41) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    45 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    41 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH08712 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011715 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1064-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Snr1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | recessive | somatic clone Snr1R3 lethal, with Scer\GAL4hs.PB Snr1cdel.3.Scer\UAS lethal | heat sensitive, with Scer\GAL4e22c, Snr1cdel.3.Scer\UAS Snr1R3 lethal | heat sensitive, with Scer\GAL4e22c, Snr1R3 Snr1cdel.3.Scer\UAS lethal | larval stage | recessive Snr101319 Snr1R3 lethal | pupal stage, with Scer\GAL4pnr-MD237 Snr1GD4140 lethal | recessive Snr101319 Snr1E1 Snr1E2 Snr1E3 Snr1E4 Snr1R3 Snr1R10 Snr1SR21 viable Snr1P1rev Sterility Allele female sterile, with Scer\GAL4Act5C.PI, Snr1cdel.3.Scer\UAS Snr1R3 female sterile, with Scer\GAL4Act5C.PI, Snr1R3 Snr1cdel.3.Scer\UAS female sterile | germline clone Snr1R3 Other Phenotypes Allele body color defective | somatic clone Snr1R3 cell shape defective | recessive Snr101319 increased cell size Snr1dsRNA.cZa large body Snr1E1 neuroanatomy defective | recessive Snr101319 non-enhancer of variegation, with In(1)wm4h Snr1P1rev non-suppressor of variegation, with In(1)wm4h Snr1P1rev short lived, with Scer\GAL4Act5C.PI, Snr1cdel.3.Scer\UAS Snr1R3 short lived, with Scer\GAL4Act5C.PI, Snr1R3 Snr1cdel.3.Scer\UAS suppressor of variegation | dominant, with In(1)wm4h Snr1E2 Snr1E3 Snr1R3 Snr1SR21 visible, with Scer\GAL469B Snr1cdel.3.Scer\UAS visible, with Scer\GAL4e22c Snr1cdel.3.Scer\UAS visible, with Scer\GAL4MD-638 Snr1GD4140 visible, with Scer\GAL4salm-459.2 Snr1GD4140 visible (with Snr1E1) Snr1R3 Snr1SR21 visible (with Snr1R3) Snr1E1 visible (with Snr1SR21) Snr1E1 visible | dominant Snr1E1 visible | dominant | heat sensitive Snr1E1 visible | recessive | somatic clone Snr1R3 Phenotype manifest in Allele adult antennal lobe projection neuron DL1 adPN Snr101319 adult cuticle | somatic clone Snr1R3 adult thorax | dorsal & chaeta | somatic clone Snr1R3 eye | somatic clone Snr1R3 mechanosensory chaeta & adult abdomen | somatic clone Snr1R3 mechanosensory chaeta | supernumerary & adult abdomen | somatic clone Snr1R3 socket & adult abdomen | somatic clone Snr1R3 tergite, with Scer\GAL4e22c Snr1cdel.3.Scer\UAS tergite, with Scer\GAL4e22c, Snr1cdel.3.Scer\UAS Snr1R3 tergite, with Scer\GAL4e22c, Snr1R3 Snr1cdel.3.Scer\UAS wing Snr1E1 wing (with Snr1E1) Snr1R3 wing (with Snr1R3) Snr1E1 wing hair | ectopic, with Scer\GAL4MD-638 Snr1GD4140 wing hair | ectopic, with Scer\GAL4salm-459.2 Snr1GD4140 wing margin, with Scer\GAL4MD-638 Snr1GD4140 wing margin, with Scer\GAL4salm-459.2 Snr1GD4140 wing sensillum | ectopic, with Scer\GAL469B Snr1cdel.3.Scer\UAS wing sensillum | ectopic, with Scer\GAL4MD-638 Snr1GD4140 wing sensillum | ectopic, with Scer\GAL4salm-459.2 Snr1GD4140 wing vein, with Scer\GAL4MD-638 Snr1GD4140 wing vein, with Scer\GAL4salm-459.2 Snr1GD4140 wing vein (with Snr1E1) Snr1SR21 wing vein (with Snr1SR21) Snr1E1 wing vein | ectopic Snr1E1 wing vein | ectopic (with Snr1E1) Snr1R3 wing vein | ectopic (with Snr1R3) Snr1E1 wing vein | ectopic | heat sensitive Snr1E1 wing vein L2, with Scer\GAL469B Snr1cdel.3.Scer\UAS
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Snr1 Class Mutagen Stocks Known lesion Snr101319 P-element activity 1 Yes Snr16C P-element activity 1 Yes Snr10319 0 -- Snr1E1 ethyl methanesulfonate 0 Yes Snr1E2 ethyl methanesulfonate 0 Yes Snr1E3 ethyl methanesulfonate 0 Yes Snr1E4 ethyl methanesulfonate 0 Yes Snr1P1rev Delta2-3 0 -- Snr1R10 Delta2-3 0 Yes Snr1R3 Delta2-3 0 Yes Snr1SR21 loss of function allele P-element activity 0 Yes Snr1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Snr1 Class Mutagen Stocks Known lesion Snr1GD4140 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Snr1HMS00363 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Snr1KK101602 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Snr1+t8.9 in vitro construct - genomic fragment 0 Yes Snr13.Scer\UAS in vitro construct - regulatory fusion 0 Yes Snr14.Scer\UAS in vitro construct - regulatory fusion 0 Yes Snr1cdel.3.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes Snr1dsRNA.cZa in vitro construct - RNAi 0 Yes Snr1hs.PZ in vitro construct - regulatory fusion 0 Yes Snr1hs.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Snr1Scer\UAS.cZa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)2-2 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3R)SR29 (Zraly et al., 2003) Df(3R)SR71 (Zraly et al., 2003)
Partially disrupted in	Df(3R)Hdac36C (Zhu et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{HA-hs-Snr1} NA P{hs-Snr1.Z} NA UAS construct P{GD4140} NA P{KK101602} NA P{TRiP.HMS00363} NA P{UAS-Snr1.1} NA P{UAS-Snr1.3} NA P{UAS-Snr1.4} NA P{UAS-snr1.cdel.3} NA characterization construct P{Snr1+t8.9} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Snr101319 No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with brm (Brumby et al., 2002) inferred from physical interaction with CycE (Brumby et al., 2002) inferred from physical interaction with Rbf (Brumby et al., 2002) SET domain binding inferred from physical interaction with trx (Marenda et al., 2003)
Biological Process
CV term Evidence References
dendrite guidance inferred from mutant phenotype (Tea and Luo, 2011) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) epidermis development inferred from mutant phenotype (Parrish et al., 2006) imaginal disc-derived wing margin morphogenesis inferred from mutant phenotype (Terriente-Félix and de Celis, 2009) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Terriente-Félix and de Celis, 2009) imaginal disc-derived wing vein specification inferred from mutant phenotype (Marenda et al., 2004, Curtis et al., 2011) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) negative regulation of cell proliferation inferred from mutant phenotype (Marenda et al., 2003) positive regulation of transcription, DNA-dependent inferred from direct assay (Kal et al., 2000)
Cellular Component
CV term Evidence References
brahma complex inferred from direct assay (Kal et al., 2000, Marenda et al., 2003) nucleus inferred from direct assay (Mohrmann et al., 2004, Dingwall et al., 1995)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
contributes_to transcription coactivator activity inferred by curator from GO:0035060 (Kal et al., 2000)
Biological Process
CV term Evidence References
ATP-dependent chromatin remodeling inferred from sequence or structural similarity with Saccharomyces SNF2 (Dingwall et al., 1995) embryonic development via the syncytial blastoderm non-traceable author statement (Marenda et al., 2003) instar larval or pupal development non-traceable author statement (Marenda et al., 2003) positive regulation of transcription, DNA-dependent inferred from sequence or structural similarity with Saccharomyces SNF2 (Dingwall et al., 1995) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with Saccharomyces SNF5 (FlyBase, 1992-) non-traceable author statement (Dingwall, 1995.6.6)
Cellular Component
CV term Evidence References
brahma complex non-traceable author statement (Marenda et al., 2003) traceable author statement (Fry and Peterson, 2001) nuclear chromosome inferred from electronic annotation with InterPro:IPR006939 (FlyBase Curators et al., 2004-) nucleus inferred from sequence or structural similarity with Saccharomyces SNF5 (FlyBase, 1992-) non-traceable author statement (Dingwall, 1995.6.6)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Snr1 - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - BEAF-32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Bap55 experimental knowledge based (Guruharsha et al., 2011) Snr1 - Bap60 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Snr1 - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG11562 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG14207 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Snr1 - CG14480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG18048 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG2017 experimental knowledge based (Guruharsha et al., 2011) Snr1 - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG6272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG7185 experimental knowledge based (Guruharsha et al., 2011) Snr1 - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG7845 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - CG8043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Cpr31A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Droj2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - E(spl)m3-HLH experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Snr1 - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - MED14 experimental knowledge based (Guruharsha et al., 2011) Snr1 - MED17 experimental knowledge based (Guruharsha et al., 2011) Snr1 - MED18 experimental knowledge based (Guruharsha et al., 2011) Snr1 - MED7 experimental knowledge based (Guruharsha et al., 2011) Snr1 - MED8 experimental knowledge based (Guruharsha et al., 2011) Snr1 - ND42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Pof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - RpL37a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Tpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - Vinc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - brm experimental knowledge based (Guruharsha et al., 2011) Snr1 - ct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - dalao experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Snr1 - dsh experimental knowledge based (Guruharsha et al., 2011) Snr1 - ebi experimental knowledge based (Guruharsha et al., 2011) Snr1 - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - hep anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - lft anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - mRpL39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - mRpL4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - miple2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - mor anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Snr1 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - p38b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - ssp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - twin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Snr1 - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Snr1 allele Gene References Snr101319 CycE (Brumby et al., 2002) osa (Collins et al., 1999) Snr1cdel.3.Scer\UAS CycE (Brumby et al., 2002) Snr1E1 ab (Marenda et al., 2004) ash1 (Marenda et al., 2004) Asx (Marenda et al., 2004) brm (Marenda et al., 2004) bs (Marenda et al., 2004) cdc2c (Zraly et al., 2004) corto (Marenda et al., 2004) cv (Marenda et al., 2004) CycE (Zraly et al., 2004) Dl (Marenda et al., 2004) dpp (Marenda et al., 2004) E(z) (Marenda et al., 2004) Egfr (Marenda et al., 2004) ex (Marenda et al., 2004) gpp (Marenda et al., 2004) gro (Marenda et al., 2004) H (Marenda et al., 2004) Hdac3 (Zraly et al., 2004) Hsc70-4 (Marenda et al., 2004) kis (Marenda et al., 2004) lawc (Marenda et al., 2004) N (Marenda et al., 2004) net (Marenda et al., 2004) Pc (Marenda et al., 2004) px (Marenda et al., 2004) rho (Marenda et al., 2004) Rpd3 (Zraly et al., 2004) RpII215 (Marenda et al., 2004) S (Marenda et al., 2004) sbb (Marenda et al., 2004) sens (Marenda et al., 2004) tkv (Marenda et al., 2004) Snr1R3 Antp (Zraly et al., 2003) brm (Dingwall et al., 1995, Zraly et al., 2003, Marenda et al., 2004) CycE (Brumby et al., 2002) Dl (Marenda et al., 2004) dpp (Marenda et al., 2004) net (Marenda et al., 2004) rho (Marenda et al., 2004) Rpd3 (Zraly et al., 2004) trx (Dingwall et al., 1995) Snr1unspecified CycE (Brumby et al., 2004) E(z) (Bajusz et al., 2001) unspecified brm (Dingwall et al., 1995, Armstrong et al., 2005) dm (Secombe et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65866 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011715 DroID - A comprehensive database of gene and protein interactions. • FBgn0011715 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40657 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24090
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69S6SF Dipteran inclusive ortholog search EOG6WSWK8 Insect inclusive ortholog search EOG6BP07F Arthropod inclusive ortholog search EOG6NCJV9 Metazoa inclusive ortholog search EOG6MH524
Orthologs in Drosophila Species (EOG69S6SF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Snr1     Drosophila simulans   Dsim\GD19788 Y   Drosophila sechellia   Dsec\GM10810 Y   Drosophila erecta   Dere\GG12837 Y   Drosophila yakuba   Dyak\GE25470 Y   Drosophila ananassae   Dana\GF17254 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26364 Y   Drosophila persimilis   Dper\GL21665 Y   Drosophila willistoni   Dwil\GK11225 Y   Drosophila virilis   Dvir\GJ22699 Y   Drosophila mojavensis   Dmoj\GI23079 Y   Drosophila grimshawi   Dgri\GH18597 Y
Orthologs in non-Drosophila Dipterans (EOG6WSWK8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004371   Anopheles gambiae Malaria mosquito  Agam\AGAP001154   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008910
Orthologs in non-Dipteran Insects (EOG6BP07F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Snr1   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009373   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10938   Atta cephalotes Leafcutter ant  Acep\ACEP20120   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17020   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15771   Linepithema humile Argentine ant  Lhum\LH13957   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26045   Solenopsis invicta Red fire ant  Sinv\SINV11312   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006268   Bombyx mori Silkmoth  Bmor\BGIBMGA013255   Pediculus humanus Human body louse  Phum\PHUM217130   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15634
Orthologs in non-Insect Arthropods (EOG6NCJV9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW008377
Orthologs in non-Arthropod Metazoa (EOG6MH524)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\snfc-5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013577gn   Danio rerio Zebrafish  Drer\smarcb1b   Danio rerio Zebrafish  Drer\smarcb1a   Xenopus tropicalis Western clawed frog  Xtro\smarcb1   Gallus gallus Domestic chicken  Ggal\SMARCB1   Rattus norvegicus Norway rat  Rnor\Smarcb1   Homo sapiens Human  Hsap\SMARCB1
Human Orthologs (1)
Gene OMIM HGNC Hsap\SMARCB1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19788 Drosophila sechellia Dsec\GM10810 Drosophila erecta Dere\GG12837 Drosophila yakuba Dyak\GE25470 Drosophila ananassae Dana\GF17254 Drosophila pseudoobscura pseudoobscura Dpse\GA26364 Drosophila persimilis Dper\GL21665 Drosophila willistoni Dwil\GK11225 Drosophila virilis Dvir\GJ22699 Drosophila mojavensis Dmoj\GI23079 Drosophila grimshawi Dgri\GH18597
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	32372 y1 sc* v1; P{TRiP.HMS00363}attP2 11529 P{PZ}Snr101319 ry506/TM3, ryRK Sb1 Ser1 34494 w*; P{FRT(whs)}2A P{neoFRT}82B Snr16C Hdac36C/TM6B, Tb1
VDRC	v108599 P{KK101602}VIE-260B v12644 w1118; P{GD4140}v12644 v12645 w1118; P{GD4140}v12645/TM3
Genomic Clones ( 2 )
	BACR24O24 BACR34M23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08712
Other clones	DPiM_GH08712
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04584 GM08391 GM10843 LD03625 LD09395 LD14451 LD18106 LD18217 LD18257 LD19880 LD20072 LD20266 LD29634 LD44627 RE10818 RE32414 RE42481 RE57758 RE63896 SD09579 SD16245 SD16824 SD20043
Other clones	67358 145717 164722 281339 CK01.17B.C6 CK01.62D.G4 CK01.93B.E1 Dmel_neb_004740_0444_1670 EK049606 EK050658 EK072817 EK152343 EK156303 EK195443 EK269252 EK306557 RM07419 RM07519 RM07619 RM07719 RM08019 RM08119
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011715 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40657
Antibody Information
	polyclonal (Dingwall et al., 1995, Zraly et al., 2003, Chalkley et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Snr1 CG1064 (Beasley, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. RNAi of Snr1 results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes defects in muscle, defects in the epidermis, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Loss of Snr1 function results in ectopic vein material in the wing. (Marenda et al., 2004) Snr1 is identified in a yeast two-hybrid screen for proteins interacting with trx. Yeast two-hybrid assays, in vitro binding assays and coimmunoprecipitation of proteins from cultured cells and transgenic flies demonstrates the trx and Snr1 proteins interact. (Rozenblatt-Rosen et al., 1998) The Snr1 and brm proteins are present in a large complex and co-precipitate from extracts, these results suggest that the Drosophila counterpart of the yeast SWI/SNF complex plays an important role in counteracting the repressive effects of chromatin on homeotic gene transcription during development. (Dingwall et al., 1995) Snr1 is essential for viability. Phenotypic studies and genetic interactions suggest that Snr1 and brm act together, and with trx, to regulate homeotic gene transcription. Snr1 and brm proteins are present in a large complex, this complex may play an important role in maintaining homeotic gene transcription during development by counteracting the repressive effect of chromatin. (Dingwall et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169055 RefSeq (Proteins) • NP_730935 DDBJ / EMBL / GenBank • AA538674 AAC77830 AAF52024 AAL47972 AI109494 AI402144 AQ026168 AY070501 U28485 Entrez Gene - A searchable database of RefSeq genes. • 40657 UniProtKB/TrEMBL • Q24090
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SNF5/SMARCB1/INI1 (IPR006939) SWI/SNF chromatin-remodeling complex, component hSNF5/Ini1 (IPR017393) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH08712
Linkouts
	BioGRID - A database of protein and genetic interactions • 65866 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011715 DroID - A comprehensive database of gene and protein interactions. • FBgn0011715 DRSC - Results from RNAi screens. • FBgn0011715 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011715 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1064-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011715 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40657 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/snr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40657 modMine - Data generated by the modENCODE project. • FBgn0011715 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24090
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BAP45 (Kal et al., 2000, Wade and Wolffe, 1999, Papoulas et al., 1998) CG1064 (Keleman et al., 2009.8.5, Gandhi et al., 2007, Ni et al., 2010.12.1) l(3)01319   snr (Vazquez et al., 1999) Snr (Smulders-Srinivasan et al., 2010) snr1 (Armstrong et al., 2005, Wang et al., 2004, Brumby et al., 2004, Zraly et al., 2004, Marenda et al., 2004, Zraly et al., 2003, Brumby et al., 2002, Gutierrez et al., 2003, Marenda et al., 2003, Zraly et al., 2002, Bajusz et al., 2001, Fry and Peterson, 2001, Zraly et al., 2001, Zraly et al., 2000, Dingwall et al., 2000, Dingwall, 1995.6.6, van Lohuizen, 1999, Pollard and Peterson, 1998, Rozenblatt-Rosen et al., 1998, Tsukiyama and Wu, 1997, Gould, 1997, Dingwall et al., 1995, Curtis et al., 2011, Zraly et al., 2006, Marenda et al., 2003, Secombe et al., 2007, Curtis et al., 2008, Chalkley et al., 2008, Nègre et al., 2011, Vázquez et al., 2008, Melicharek et al., 2008, Zhu et al., 2008, Terriente-Félix and de Celis, 2009, Nakamura et al., 2008, Kleefstra et al., 2012, Zraly and Dingwall, 2012) SNR1 (Eberharter and Becker, 2004, Aalfs and Kingston, 2000, Sudarsanam and Winston, 2000, Curtis et al., 2008, Taylor-Harding et al., 2004, Still et al., 2004, Moshkin et al., 2009, Reddy et al., 2010, Vorobyeva et al., 2009) Snr1 (Schuettengruber et al., 2007, Parrish et al., 2006, Gan et al., 2010, Vorobyeva et al., 2009, Waldholm et al., 2011, Toku et al., 2011, Kinstrie et al., 2006, Diop et al., 2008, Herr et al., 2010, Di Stefano et al., 2011, Nowak et al., 2012, Tea and Luo, 2011, Nakayama et al., 2012, Dekanty et al., 2010, Soshnikova et al., 2008, Tokusumi et al., 2012, Antao et al., 2012) Snr1/BAP45 (Mohrmann et al., 2004)
Name Synonym	snf5-related 1 (Dingwall et al., 1995) Snf5-related 1 (Nègre et al., 2011, Waldholm et al., 2011, Kinstrie et al., 2006)
Secondary FlyBase IDs
	FBgn0010744
References ( 100 )
Generate a list of	All references relating to this gene ( 100 )
List References by type	Research paper  ( 56 ) Supplementary material  ( 6 ) Review  ( 15 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 12 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Kleefstra et al., 2012, Am. J. Hum. Genet. 91(1): 73--82 Disruption of an EHMT1-Associated Chromatin-Modification Module Causes Intellectual Disability. [FBrf0218925] Nakayama et al., 2012, Development 139(24): 4582--4590 The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. [FBrf0219981] Nowak et al., 2012, PLoS Genet. 8(3): e1002547 Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis. [FBrf0217616] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Zraly and Dingwall, 2012, Nucleic Acids Res. 40(13): 5975--5987 The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit. [FBrf0218975] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Tea and Luo, 2011, Neural Dev. 6: 5 The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting. [FBrf0213006] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Waldholm et al., 2011, BMC Mol. Biol. 12: 46 SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. [FBrf0216757] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...