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Gene Dmel\Tig

General Information
Symbol	Dmel\Tig	Species	D. melanogaster
Name	Tiggrin	Annotation symbol	CG11527
Feature type	protein_coding_gene	FlyBase ID	FBgn0011722
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	CT36389
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26D1-26D1	Sequence location	2L:6,415,179..6,423,310 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tiggrin is referred to in FlyBase by the symbol Dmel\Tig (CG11527, FBgn0011722). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: axon guidance; cell-substrate adhesion; substrate adhesion-dependent cell spreading; regulation of cell adhesion mediated by integrin; cell adhesion mediated by integrin; phagocytosis, engulfment. 10 alleles are reported. The phenotypes of these alleles are annotated with: hypodermal muscle of larval abdomen; organ system; ISN innervated muscle of A1-7; hypodermal muscle of larval abdominal 2; larval abdominal segment; abdominal 7 longitudinal muscle; A1-7 ventral longitudinal muscle 3; adult segment; abdominal 6 longitudinal muscle; adult. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Haem oxygenase-like, multi-helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval fat body, inseminated spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval hindgut, adult heart, adult fat body, larval trachea, virgin spermatheca, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634546_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tig. Gene sequence location is 2L:6415257..6423308.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides Tig-PB Transcripts Tig-RB
FB2013_02	Controlled Vocabulary Terms extracellular matrix substrate adhesion-dependent cell spreading cell adhesion mediated by integrin basement membrane
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26D1-26D1   Limits computationally determined from genome sequence between P{lacW}l(2)k09923k09923&P{lacW}CG9523k07502b and P{EP}Sec61αEP2180
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26D1-26D2     (Fogerty, 1994.5.9) 26D1-26D2   (determined by in situ hybridisation)   (Fogerty et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tig for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tig-RA FBtr0079275  NM_057685   6929   2188 Tig-RB FBtr0343152     7018   2188
Additional Transcript Data & Comments
Reported size (kB)	7.0 (northern blot) (Fogerty et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tig-PA   FBpp0078905   257.4   2188   5.80     NP_477033   AAF52380 Tig-PB   FBpp0309850   257.4   2188   5.80
Additional Polypeptide Data & Comments
Reported size (kDa)	2186 (aa); 220 (kD observed); 255 (kD predicted) (Fogerty et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Haem oxygenase-like, multi-helical (IPR016084)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52380   AC005419   AC093100   AI064027   AI107686   AI109575   AI134528   AI238132   AI296030   AI389719   AI519374   BG632227   BG639423   BI232855   BP552131   BP552132   BT010260 AAQ23578   CK661537   CO155640   CO156701   CO272113   CO274419   CO296047   CO297692   CO305984   CO319853   CO335990   CO337415   EC059426   EC066038   EC079832   EC087041   EC209448   EC209606   EC222807   EC243711   EC247586   EC250442   EC261552   EC263071   EC266592   ES694919   GH739842   GH740968   GH741112   GH741176   GH741537   GH742027   GH742135   GH743964   GH744037   GH744469   GH745622   GH746193   GH747050   GH747062   GH762844   GH763184   GH763674   GH763890   GH764200   GH764301   GH765273   GH765882   GH767627   GH767847   GH769559   U09506 AAA56998
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMD9 Q23984 Q6NR23
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12   hemocyte   (Fogerty et al., 1994) embryonic stage 13 -- 16   embryonic/larval fat body   (Fisher et al., 2012) embryonic stage 14   fat body   (Fogerty et al., 1994)
Additional Descriptive Data
	On northern blots, Tig transcripts are first detected at 6-8hrs, peak at 12-14hrs and decline to a low level by the end embryogenesis. A second peak occurs in the late 2nd instar larval to early third instar larval period. By in situ hybridization, transcripts are first detected in hemocytes at stage 12. By stage 14, they are seen in hemocytes throughout the embryo and in fat body. (Fogerty et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   commissure   (Fogerty et al., 1994) metameric furrow   (Fogerty et al., 1994) hemocyte   (Fogerty et al., 1994) embryonic/larval fat body   (Fogerty et al., 1994) embryonic stage & larval stage   muscle attachment site   (Fogerty et al., 1994) adult stage   mesothoracic extracoxal depressor muscle 66   (Fogerty et al., 1994) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference   Kc167 cell-line   (Kumagai et al., 2000) Comment:in conditioned medium
Additional Descriptive Data
	Tig protein is first detected in 8-10hr embryos on western blots. Levels continue to increase throughout embryogenesis. Tig protein is found throughout the larval stages with a peak at 3rd instar. Levels drop markedly at pupation and remain low in pupae and adults. In embryos, Tig protein is detected in hemocytes and fat body by immunolocalization. It accumulates generally in basement membrane and is found at segmental furrows, at sites where muscle apodemes form, and later, at muscle-epidermis attachment sites. Ventral nerve cord commissures are also stained. In larval musculature, Tig protein is most prominent at the muscle-epidermal attachment sites and is also present in ECM surrounding somatic muscles and in basement membrane underlying the epidermis. In adults, it is found at the Z bands of striated jump muscle. (Fogerty et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basement membrane inferred from direct assay (Fogerty et al., 1994) extracellular matrix inferred from direct assay (Fogerty et al., 1994) proteinaceous extracellular matrix inferred from direct assay AND inferred from sequence or structural similarity (Fessler et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval fat body, inseminated spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval hindgut, adult heart, adult fat body, larval trachea, virgin spermatheca, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body    2172.8 Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body  (2172.8) Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca  (691.7) Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body  (2172.8) Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body    2172.8 Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body    2172.8 Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body  (2172.8) Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca  691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body  (2172.8) Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    19.45 Larval Midgut    12.7 Larval Hindgut    156.1 Larval Malpighian Tubules    17.6 Larval Fat Body    2172.8 Larval Salivary Gland    79.8 Larval Trachea    130.125 Larval Carcass    107.575 Adult Head    164.7 Adult Eye    108.825 Adult Brain    27.1 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    64 Adult Midgut    10.8 Adult Hindgut    69.3 Adult Malpighian Tubules    12.1 Adult Fat Body    438.5 Adult Salivary Gland    17.9 Adult Heart    208.5 Adult VirginFemale Spermatheca    388.1 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    3.2 Adult Testis    19.5 Adult Male Accessory Gland    10.9 Adult Carcass    261.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    164.7   NA  Eye    108.825   NA  Brain    no informative data   19.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    64   no informative data  Midgut    no informative data   156.1  Hindgut    69.3   no informative data  Malpighian Tubules    no informative data   2172.8  Fat Body    438.5   79.8  Salivary Gland    no informative data   NA  Heart    208.5   130.125  Trachea    NA   NA  VirginFemale Spermatheca    388.1   NA  InseminatedFemale Spermatheca    691.7   NA  Ovary    3.2   NA  Testis    19.5   NA  Male Accessory Gland    no informative data   107.575  Carcass    261.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female    45 head, virgin 4-day female    21 head, virgin 20-day female    27 head, mated 1-day female    34 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    30 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    324 fat body, white prepupae    44 fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult    34 carcass, 4-day adult    28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female  (45) head, virgin 4-day female    21 head, virgin 20-day female  (27) head, mated 1-day female  (34) head, mated 4-day female  26 head, mated 20-day female  (27) head, mated 1-day male  (30) head, mated 4-day male    22 head, mated 20-day male  (27) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering  (324) fat body, white prepupae  (44) fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult  (34) carcass, 4-day adult  (28) carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female    45 head, virgin 4-day female    21 head, virgin 20-day female    27 head, mated 1-day female    34 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    30 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering  (324) fat body, white prepupae    44 fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult    34 carcass, 4-day adult    28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female    45 head, virgin 4-day female    21 head, virgin 20-day female    27 head, mated 1-day female    34 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    30 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    324 fat body, white prepupae    44 fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult    34 carcass, 4-day adult    28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female    45 head, virgin 4-day female    21 head, virgin 20-day female    27 head, mated 1-day female    34 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    30 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    324 fat body, white prepupae    44 fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult    34 carcass, 4-day adult    28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female  (45) head, virgin 4-day female    21 head, virgin 20-day female  27 head, mated 1-day female  (34) head, mated 4-day female  26 head, mated 20-day female  27 head, mated 1-day male  30 head, mated 4-day male    22 head, mated 20-day male  27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering  (324) fat body, white prepupae  (44) fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult  (34) carcass, 4-day adult  28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female    45 head, virgin 4-day female    21 head, virgin 20-day female    27 head, mated 1-day female    34 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    30 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering  (324) fat body, white prepupae    44 fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult    34 carcass, 4-day adult    28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    5 central nervous system, pupae P8    3 head, virgin 1-day female    45 head, virgin 4-day female    21 head, virgin 20-day female    27 head, mated 1-day female    34 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    30 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    324 fat body, white prepupae    44 fat body, pupae P8    5 carcass, larvae L3 wandering    23 carcass, 1-day adult    34 carcass, 4-day adult    28 carcass, 20-day adult    24 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr    39 embryo 12-14hr    80 embryo 14-16hr    206 embryo 16-18hr    213 embryo 18-20hr    212 embryo 20-22hr    114 embryo 22-24hr    109 larva L1    118 larva L2    168 larva L3 12hr old    172 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr  (39) embryo 12-14hr  (80) embryo 14-16hr  (206) embryo 16-18hr  (213) embryo 18-20hr  (212) embryo 20-22hr  (114) embryo 22-24hr  (109) larva L1  (118) larva L2  (168) larva L3 12hr old  (172) larva L3 puffstage 1-2  (70) larva L3 puffstage 3-6  (59) larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr    39 embryo 12-14hr    80 embryo 14-16hr  (206) embryo 16-18hr  (213) embryo 18-20hr  (212) embryo 20-22hr  (114) embryo 22-24hr  (109) larva L1  (118) larva L2  (168) larva L3 12hr old  (172) larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr    39 embryo 12-14hr    80 embryo 14-16hr    206 embryo 16-18hr    213 embryo 18-20hr    212 embryo 20-22hr    114 embryo 22-24hr    109 larva L1    118 larva L2    168 larva L3 12hr old    172 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr    39 embryo 12-14hr    80 embryo 14-16hr    206 embryo 16-18hr    213 embryo 18-20hr    212 embryo 20-22hr    114 embryo 22-24hr    109 larva L1    118 larva L2    168 larva L3 12hr old    172 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr  (39) embryo 12-14hr  (80) embryo 14-16hr  (206) embryo 16-18hr  (213) embryo 18-20hr  (212) embryo 20-22hr  (114) embryo 22-24hr  (109) larva L1  (118) larva L2  (168) larva L3 12hr old  (172) larva L3 puffstage 1-2  (70) larva L3 puffstage 3-6  (59) larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr    39 embryo 12-14hr    80 embryo 14-16hr  (206) embryo 16-18hr  (213) embryo 18-20hr  (212) embryo 20-22hr  114 embryo 22-24hr  109 larva L1  118 larva L2  (168) larva L3 12hr old  (172) larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    13 embryo 10-12hr    39 embryo 12-14hr    80 embryo 14-16hr    206 embryo 16-18hr    213 embryo 18-20hr    212 embryo 20-22hr    114 embryo 22-24hr    109 larva L1    118 larva L2    168 larva L3 12hr old    172 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    17 white prepupae new    8 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    7 pupae 3d postWPP    24 pupae 4d postWPP    25 adult male 01day    21 adult male 05day    16 adult male 30day    22 adult female 01day    15 adult female 05day    12 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    86 embryonic 1182-4H    213 embryonic GM2    123 embryonic Kc167    36 embryonic S1    57 embryonic S3    28 leg disc CME L1    134 wing disc CME-W2    26 wing disc ML-DmD8    8 wing disc ML-DmD9    80 wing disc ML-DmD16-c3    136 wing disc ML-DmD21    3 wing disc ML-DmD32    182 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    187 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (86) embryonic 1182-4H  (213) embryonic GM2  (123) embryonic Kc167  (36) embryonic S1  (57) embryonic S3  (28) leg disc CME L1  (134) wing disc CME-W2  26 wing disc ML-DmD8    8 wing disc ML-DmD9  (80) wing disc ML-DmD16-c3  (136) wing disc ML-DmD21    3 wing disc ML-DmD32  (182) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2  (187) ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    86 embryonic 1182-4H  (213) embryonic GM2  (123) embryonic Kc167    36 embryonic S1    57 embryonic S3    28 leg disc CME L1  (134) wing disc CME-W2    26 wing disc ML-DmD8    8 wing disc ML-DmD9    80 wing disc ML-DmD16-c3  (136) wing disc ML-DmD21    3 wing disc ML-DmD32  (182) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2  (187) ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    86 embryonic 1182-4H    213 embryonic GM2    123 embryonic Kc167    36 embryonic S1    57 embryonic S3    28 leg disc CME L1    134 wing disc CME-W2    26 wing disc ML-DmD8    8 wing disc ML-DmD9    80 wing disc ML-DmD16-c3    136 wing disc ML-DmD21    3 wing disc ML-DmD32    182 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    187 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    86 embryonic 1182-4H    213 embryonic GM2    123 embryonic Kc167    36 embryonic S1    57 embryonic S3    28 leg disc CME L1    134 wing disc CME-W2    26 wing disc ML-DmD8    8 wing disc ML-DmD9    80 wing disc ML-DmD16-c3    136 wing disc ML-DmD21    3 wing disc ML-DmD32    182 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    187 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (86) embryonic 1182-4H  (213) embryonic GM2  (123) embryonic Kc167  (36) embryonic S1  (57) embryonic S3  28 leg disc CME L1  (134) wing disc CME-W2  26 wing disc ML-DmD8    8 wing disc ML-DmD9  (80) wing disc ML-DmD16-c3  (136) wing disc ML-DmD21    3 wing disc ML-DmD32  (182) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2  (187) ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    86 embryonic 1182-4H  (213) embryonic GM2  123 embryonic Kc167    36 embryonic S1    57 embryonic S3    28 leg disc CME L1  134 wing disc CME-W2    26 wing disc ML-DmD8    8 wing disc ML-DmD9    80 wing disc ML-DmD16-c3  136 wing disc ML-DmD21    3 wing disc ML-DmD32  (182) haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2  (187) ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    86 embryonic 1182-4H    213 embryonic GM2    123 embryonic Kc167    36 embryonic S1    57 embryonic S3    28 leg disc CME L1    134 wing disc CME-W2    26 wing disc ML-DmD8    8 wing disc ML-DmD9    80 wing disc ML-DmD16-c3    136 wing disc ML-DmD21    3 wing disc ML-DmD32    182 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    187 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    69 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    76 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    68 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult  (50) Cadmium 50 mM 6 hrs, larvae L3  (69) Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult  (86) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (76) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3  (55) Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3  (62) Ethanol 10% 3 hrs, larvae L3  (68) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (60) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3  (41) Rotenone 8 μg 12 hrs, larvae L3  (94) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    69 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    76 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    68 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    69 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    76 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    68 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    94 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    69 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    76 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    68 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult  (50) Cadmium 50 mM 6 hrs, larvae L3  (69) Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult  (86) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (76) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3  (55) Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3  (62) Ethanol 10% 3 hrs, larvae L3  (68) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (60) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3  (41) Rotenone 8 μg 12 hrs, larvae L3  (94) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    69 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    76 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    68 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    69 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    86 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    76 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    68 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    41 Rotenone 8 μg 12 hrs, larvae L3    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	BDGP expression data • RE28982 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011722 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11527-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tig Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive Tigx partially lethal - majority die (with TigA1) Tigx partially lethal - majority die (with Tigx) TigA1 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 TigGD12430 partially lethal - majority die | recessive TigA1 TigO2 Other Phenotypes Allele neuroanatomy defective Tigx Phenotype manifest in Allele abdominal 2 lateral oblique muscle 1 Tigx abdominal 2 segment border muscle Tigx abdominal 2 ventral longitudinal muscle 3 Tigx abdominal 2 ventral longitudinal muscle 4 Tigx abdominal 3 lateral oblique muscle 1 Tigx abdominal 3 segment border muscle Tigx abdominal 3 ventral longitudinal muscle 3 Tigx abdominal 3 ventral longitudinal muscle 4 Tigx abdominal 4 lateral oblique muscle 1 Tigx abdominal 4 segment border muscle Tigx abdominal 4 ventral longitudinal muscle 3 Tigx abdominal 4 ventral longitudinal muscle 4 Tigx abdominal 5 lateral oblique muscle 1 Tigx abdominal 5 segment border muscle Tigx abdominal 5 ventral longitudinal muscle 3 Tigx abdominal 5 ventral longitudinal muscle 4 Tigx abdominal 6 lateral oblique muscle 1 Tigx abdominal 6 segment border muscle Tigx abdominal 6 ventral longitudinal muscle 3 Tigx abdominal 6 ventral longitudinal muscle 4 Tigx abdominal 7 lateral oblique muscle 1 Tigx abdominal 7 segment border muscle Tigx abdominal 7 ventral longitudinal muscle 3 Tigx abdominal 7 ventral longitudinal muscle 4 Tigx adult abdomen TigA1 TigO2 Tigx air bubble TigA1 Tigx embryonic/larval somatic muscle TigA1 Tigx fascicle Tigx pupa TigA1 Tigx wing TigA1 Tigx
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Tig Class Mutagen Stocks Known lesion TigA1 ethyl methanesulfonate 1 -- Tigx Delta2-3 1 Yes TigO2 ethyl methanesulfonate 0 -- Tigx2 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tig Class Mutagen Stocks Known lesion TigGD12430 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TigJF01143 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TigKK103086 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TigLGA.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes TigNIG.11527R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TigScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12430} NA P{KK103086} NA P{NIG.11527R} NA P{TRiP.JF01143} NA P{UAS-Tig.B} NA P{UAS-Tig.LGA} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}k09239 No P{lacW}l(2)SH1968SH1968 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Stevens and Jacobs, 2002) cell adhesion mediated by integrin inferred from direct assay (Fogerty et al., 1994) cell-substrate adhesion inferred from mutant phenotype (Zhang et al., 2010) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of cell adhesion mediated by integrin inferred from genetic interaction with pgant3 (Zhang et al., 2008) substrate adhesion-dependent cell spreading inferred from direct assay (Fogerty et al., 1994)
Cellular Component
CV term Evidence References
basement membrane inferred from direct assay (Fogerty et al., 1994) extracellular matrix inferred from direct assay (Fogerty et al., 1994) proteinaceous extracellular matrix inferred from direct assay AND inferred from sequence or structural similarity (Fessler et al., 1994)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
proteinaceous extracellular matrix non-traceable author statement (Fogerty, 1994.5.9)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tig allele Gene References Tigx rhea (Martin-Bermudo and Brown, 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60053 DroID - A comprehensive database of gene and protein interactions. • FBgn0011722 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33896
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62NJJM Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG62NJJM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tig     Drosophila simulans   Dsim\GD22579 Y   Drosophila sechellia   Dsec\GM17942 Y   Drosophila erecta   Dere\GG23626 Y   Drosophila yakuba   Dyak\GE18445 Y   Drosophila ananassae   Dana\GF15390 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11052 Y   Drosophila persimilis   Dper\GL26260 Y   Drosophila willistoni   Dwil\GK15356 Y   Drosophila virilis   Dvir\GJ15168 Y   Drosophila mojavensis   Dmoj\GI17497 Y   Drosophila grimshawi   Dgri\GH10985 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22579 Drosophila sechellia Dsec\GM17942 Drosophila erecta Dere\GG23626 Drosophila yakuba Dyak\GE18445 Drosophila ananassae Dana\GF15390 Drosophila pseudoobscura pseudoobscura Dpse\GA11052 Drosophila persimilis Dper\GL26260 Drosophila willistoni Dwil\GK15356 Drosophila virilis Dvir\GJ15168 Drosophila mojavensis Dmoj\GI17497 Drosophila grimshawi Dgri\GH10985
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31570 y1 v1; P{TRiP.JF01143}attP2 8796 w*; Tigx/CyO, P{lacZ-un3}276 8795 w*; TigA1/CyO, P{lacZ-un3}276
VDRC	v100036 P{KK103086}VIE-260B v28255 w1118; P{GD12430}v28255/TM3 v28257 w1118; P{GD12430}v28257/TM3
Genomic Clones ( 2 )
	BACR05J04 BACR37F23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE28982
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04274 GH05366 GH05502 GH08810 GH12016 GH14132 GH20957 LD38943 LP21123
Other clones	EK105916 EK114049 EK170343 EK212559 EK249940 EK281059 EN06456 EN08638 EN11617 EN14517 FGM217A05 LP09822 RP001001919 RP001003772 RP001005159 RP001006332 RP001008512 RP001009535 RP001012123 RP001013382 RP001014657 RP001021218 RP001028220 RP001029871 RP001031396 RP001031799 RP001036811 RP001038365 RP001040485 RP001040841 RP001044154 RP001046826 RP001047352 RP001051170 RP001051309 RP001053600 RP001054228
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011722 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33896
Antibody Information
	monoclonal (Kumagai et al., 2000) polyclonal (Fogerty et al., 1994, Deng et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tig CG11527 (Deng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Muscle connections, function and morphology are defective in Tig mutants. (Bunch et al., 1998) Tig encodes a extracellular matrix protein which is a good candidate for an aPS2ΒPS integrin ligand. (Fogerty et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057685 RefSeq (Proteins) • NP_477033 DDBJ / EMBL / GenBank • AAA56998 AAF52380 AAQ23578 AC005419 AC093100 BI232855 BT010260 U09506 Entrez Gene - A searchable database of RefSeq genes. • 33896 UniProtKB/TrEMBL • Q6NR23 Q9VMD9 Q23984
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Haem oxygenase-like, multi-helical (IPR016084) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE28982
Linkouts
	BioGRID - A database of protein and genetic interactions • 60053 DroID - A comprehensive database of gene and protein interactions. • FBgn0011722 DRSC - Results from RNAi screens. • FBgn0011722 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011722 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11527-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011722 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33896 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/tiggrin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33896 modMine - Data generated by the modENCODE project. • FBgn0011722
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG11527 (Keleman et al., 2009.8.5, Ni et al., 2008, Cammarato et al., 2011) CT36389 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) tig (MacMullin and Jacobs, 2006, Siechen and Chiba, 2000, Bunch et al., 1998, Vanderploeg et al., 2012, Avet-Rochex et al., 2010) TIG (Graner et al., 1998) Tig (Stroschein-Stevenson et al., 2006, Chanana et al., 2007, Blauwkamp et al., 2008, Sandmann et al., 2006, Liu et al., 2009, Wertheim et al., 2011, Zhang et al., 2008, Zeitlinger et al., 2007, Fernández-Ayala et al., 2010, Zhang et al., 2010, Wasbrough et al., 2010, Deng et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	tiggrin (Jasper et al., 2001, Brown, 2000, Brown et al., 2000, Grabbe et al., 2004, Fogerty, 1994.5.9, Bunch et al., 1998, Lo, 2006, Clark and Beckerle, 2008, Kumagai et al., 2000, Ellis et al., 2011, Devenport et al., 2007, Tanentzapf and Brown, 2006, Zhang et al., 2008, Avet-Rochex et al., 2010, Zhang et al., 2010, Boyle et al., 2010) Tiggrin (Bunch et al., 2006, Chanana et al., 2007, Subramanian et al., 2007, Kallappagoudar et al., 2010, Blauwkamp et al., 2008, Tanentzapf and Brown, 2006, Yuan et al., 2010, Pines et al., 2011, Cammarato et al., 2011, Deng et al., 2010)
Secondary FlyBase IDs
References ( 80 )
Generate a list of	All references relating to this gene ( 80 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 10 ) Review  ( 8 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 5 )
	Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Ellis et al., 2011, J. Cell Sci. 124(11): 1844--1856 In vivo functional analysis reveals specific roles for the integrin-binding sites of talin. [FBrf0213701] Pines et al., 2011, Dev. Dyn. 240(1): 36--51 Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis. [FBrf0212613] Wertheim et al., 2011, Mol. Ecol. 20(5): 932--949 Functional genomics of the evolution of increased resistance to parasitism in Drosophila. [FBrf0213049] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...