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Gene Dmel\tsr

General Information
Symbol	Dmel\tsr	Species	D. melanogaster
Name	twinstar	Annotation symbol	CG4254
Feature type	protein_coding_gene	FlyBase ID	FBgn0011726
Gene Model Status	Current	Stock availability	28 publicly available
Also Known As	ntf, cofilin, Adf, D-cof, l(2)k05633
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60B5-60B5	Sequence location	2R:19,931,971..19,934,359 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene twinstar is referred to in FlyBase by the symbol Dmel\tsr (CG4254, FBgn0011726). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin binding. There is experimental evidence for 16 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; sensory organ development; establishment of planar polarity; post-embryonic appendage morphogenesis; cell division; biological regulation; cellular process involved in reproduction; actin filament-based process; regulation of cellular component organization; protein complex biogenesis; central nervous system development; female gonad development; organ morphogenesis. 49 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; sensillum; external compound sense organ; organ system; cytoplasmic part; cellular process involved in reproduction; cell projection; cell cycle; spermatocyte; actomyosin contractile ring; meiosis II; cell projection membrane; wing hair; imaginal precursor; adult cuticle. It has one annotated transcript and one annotated polypeptide. Protein features are: Actin-binding, cofilin/tropomyosin type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623463_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of tsr. Gene sequence location is 2R:19931971..19934359.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	Controlled Vocabulary Terms cell morphogenesis imaginal disc-derived leg segmentation Sequence features BKN28706 HFA04718 References D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B5-60B5   Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A-60B     (Edwards, 1994.3.30) 60B4-60B5   (determined by in situ hybridisation)   (Spradling et al., 1999) 60A-60D     (Chen, 1998.3.12) 60B4-60B5     (Beaton, 1997.12.27) 60B3-60B5   60B4--5   (BDGP Project Members, 1994-1999) 60A10-60B1   Also placed in 60A8--60A16 by deficiency mapping. (determined by in situ hybridisation)   (Gunsalus et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)	sp (Chen et al., 2001)
Right of (cM)	px (Chen et al., 2001)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tsr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tsr-RA FBtr0072188  NM_057686   771   148
Additional Transcript Data & Comments
Reported size (kB)	0.8-0.9 (northern blot) (Gunsalus et al., 1995) 0.7 (longest cDNA) (Edwards et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tsr-PA   FBpp0072097   17.2   148   7.24     NP_477034   AAF47146
Additional Polypeptide Data & Comments
Reported size (kDa)	148 (aa) (Edwards et al., 1994) 17 (aa); 148 (kD) (Gunsalus et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441478   AA567190   AA696258   AA736147   AA803668   AA820621   AA950590   AE013599 AAF47146   AC004642   AI062940   AI134359   AI257183   AI258047   AI258758   AI296681   AI388171   AI515146   AI532163   AQ025765   AY231812   AY232186   AY432884   AY441275   BE975668   BG635436   BG636345   BG637061   BG639642   BG640305   BG640922   BG640963   BG641023   BI163684   BI163855   BI163979   BI164557   BI165896   BI167550   BI168201   BI168542   BI168742   BI169605   BI169777   BI173013   BI173748   BI212464   BI212838   BI213140   BI213748   BI214384   BI228990   BI229923   BI230093   BI231082   BI234998   BI235736   BI235807   BI235872   BI237462   BI239669   BI240987   BI241714   BI242007   BI243593   BI243862   BI352062   BI353433   BI353442   BI354007   BI357222   BI358216   BI361453   BI361515   BI361765   BI362767   BI364447   BI366616   BI367543   BI367862   BI373675   BI374178   BI481678   BI481873   BI482368   BI482884   BI483138   BI483933   BI486288   BI486440   BI577775   BI579843   BI580702   BI632401   BI635774   BI636103   BI636258   BI637314   BI638401   BI638488   BI638498   BI638616   BI641712   BI641970   BP541076   BP541335   BP541507   BP541988   BP542128   BP542517   BP542734   BP543329   BP543330   BP543462   BP543652   BP543653   BP543867   BP544163   BP544164   BP545037   BP545038   BP545592   BP545748   BP545804   BP545840   BP545855   BP546081   BP546090   BP546363   BP546970   BP547072   BP547249   BP547748   BP547950   BP548057   BP548192   BP548549   BP549390   BP549391   BP551162   BP551163   BP551554   BP551555   BP551865   BP551866   BP553964   BP554111   BP554112   BP555555   BP555556   BP555588   BP556464   BP556465   BT022688   BT089017   BX011388   BX011415   BX013184   BX017444   BX021953   BX023860   BX025764   BX030901   BX036222   BX047756   BX061063   BX070601   CK660618   CL868481   CO152691   CO152730   CO152962   CO153217   CO153336   CO153376   CO153498   CO153834   CO154303   CO154574   CO154708   CO155612   CO155927   CO156378   CO156540   CO156932   CO179886   CO180062   CO180458   CO180478   CO180889   CO181316   CO181666   CO181855   CO182172   CO182565   CO184367   CO185555   CO186986   CO191197   CO191239   CO191396   CO192678   CO195009   CO195619   CO284037   CO305108   CO329407   CO335475   CO335888   CO336218   CO336269   CZ469867   CZ474596   CZ489582   DQ440489   DQ443123   DQ443357   EC056966   EC057023   EC206371   EC249103   EC250660   EC260837   EC260849   EC262685   EC262849   EC262945   EC262981   EC263037   EC263063   EC263242   EC264588   EC265020   EC265361   EC265371   EC265469   EC265979   EC266749   EC267202   EC267221   EC267375   EL882316   EL882686   EV576250   EV576358   EV576596   EV576599   EV576706   EV577170   EV578308   EV579225   EV580547   EV580705   EV580917   EV581774   EV581962   EV582135   EV582546   EV582727   EV582765   EV583401   EV583721   EV584332   EV584501   EV585662   EV592144   EV597975   GH747938   GH749115   GH750140   GH753494   GH758630   GH758938   GH760454   GH770810   GH773104   GH775066   GH775395   GH777779   GH778348   GH782622   GH784627   GH785598   GH787120   GH787718   GH788858   GH789307   GH789319   GH792300   GH792918   GH798130   GH800614   GH801074   GH804541   GH805384   GH805661   GH808115   GH809843   GH811856   GH812068   GH815762   GH816098   GH817864   GH819570   GH820249   GH821556   GH824582   GH835003   GH836671   GH836848   GH837013   GH839529   GH842322   GH842843   GH847837   GH848103   GH849012   GH850366   GH851493   GH852549   GH852752   GH852831   GH854527   GH856634   GH856684   GH858245   GH858341   GH858533   GH860077   GH863146   GH864472   GH865836   GH872512   GH874404   GH874471   GH880570   GH882160   GH882409   GH882476   GH882701   GH884520   GH894236   GH898795   GH900253   GH902617   GH906863   GH907693   GH908025   GH909802   GH910293   GH911409   GH911676   GH911853   GH913046   GH917280   GH917910   GH919758   GH924509   GH925025   GH927160   GH927683   GH933601   GH938690   GH939067   GH939427   U08217 AAA19856   U24490 AAC46962   U24676 AAC46963
UniProtKB/Swiss-Prot	P45594
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Gunsalus et al., 1995)
Additional Descriptive Data
	tsr transcript is detected throughout development, with peaks of expression in late larval and pupal stages. (Gunsalus et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011726    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011726 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011726 expression level Developmental Stage   Expression Level embryo 00-02hr    35899 embryo 02-04hr    56257 embryo 04-06hr    71419 embryo 06-08hr    38869 embryo 08-10hr    35442 embryo 10-12hr    35262 embryo 12-14hr    36637 embryo 14-16hr    20617 embryo 16-18hr    27061 embryo 18-20hr    18668 embryo 20-22hr    22971 embryo 22-24hr    32050 larva L1    24735 larva L2    41846 larva L3 12hr old    36995 larva L3 puffstage 1-2    41925 larva L3 puffstage 3-6    39316 larva L3 puffstage 7-9    62563 white prepupae new    57658 white prepupae 12hr    42425 white prepupae 24hr    40241 pupae 2d postWPP    30360 pupae 3d postWPP    20892 pupae 4d postWPP    12937 adult male 01day    10558 adult male 05day    8873 adult male 30day    7696 adult female 01day    14350 adult female 05day    31809 adult female 30day    29487 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (35899) embryo 02-04hr  (56257) embryo 04-06hr  (71419) embryo 06-08hr  (38869) embryo 08-10hr  (35442) embryo 10-12hr  (35262) embryo 12-14hr  (36637) embryo 14-16hr  (20617) embryo 16-18hr  (27061) embryo 18-20hr  (18668) embryo 20-22hr  (22971) embryo 22-24hr  (32050) larva L1  (24735) larva L2  (41846) larva L3 12hr old  (36995) larva L3 puffstage 1-2  (41925) larva L3 puffstage 3-6  (39316) larva L3 puffstage 7-9  (62563) white prepupae new  (57658) white prepupae 12hr  (42425) white prepupae 24hr  (40241) pupae 2d postWPP  (30360) pupae 3d postWPP  (20892) pupae 4d postWPP  (12937) adult male 01day  (10558) adult male 05day  (8873) adult male 30day  (7696) adult female 01day  (14350) adult female 05day  (31809) adult female 30day  (29487) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35899) embryo 02-04hr  (56257) embryo 04-06hr  (71419) embryo 06-08hr  (38869) embryo 08-10hr  (35442) embryo 10-12hr  (35262) embryo 12-14hr  (36637) embryo 14-16hr  (20617) embryo 16-18hr  (27061) embryo 18-20hr  (18668) embryo 20-22hr  (22971) embryo 22-24hr  (32050) larva L1  (24735) larva L2  (41846) larva L3 12hr old  (36995) larva L3 puffstage 1-2  (41925) larva L3 puffstage 3-6  (39316) larva L3 puffstage 7-9  (62563) white prepupae new  (57658) white prepupae 12hr  (42425) white prepupae 24hr  (40241) pupae 2d postWPP  (30360) pupae 3d postWPP  (20892) pupae 4d postWPP  (12937) adult male 01day  (10558) adult male 05day  (8873) adult male 30day  (7696) adult female 01day  (14350) adult female 05day  (31809) adult female 30day  (29487) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (35899) embryo 02-04hr  (56257) embryo 04-06hr  (71419) embryo 06-08hr  (38869) embryo 08-10hr  (35442) embryo 10-12hr  (35262) embryo 12-14hr  (36637) embryo 14-16hr  (20617) embryo 16-18hr  (27061) embryo 18-20hr  (18668) embryo 20-22hr  (22971) embryo 22-24hr  (32050) larva L1  (24735) larva L2  (41846) larva L3 12hr old  (36995) larva L3 puffstage 1-2  (41925) larva L3 puffstage 3-6  (39316) larva L3 puffstage 7-9  (62563) white prepupae new  (57658) white prepupae 12hr  (42425) white prepupae 24hr  (40241) pupae 2d postWPP  (30360) pupae 3d postWPP  (20892) pupae 4d postWPP  (12937) adult male 01day  10558 adult male 05day    8873 adult male 30day    7696 adult female 01day  (14350) adult female 05day  (31809) adult female 30day  (29487) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35899 embryo 02-04hr    56257 embryo 04-06hr    71419 embryo 06-08hr    38869 embryo 08-10hr    35442 embryo 10-12hr    35262 embryo 12-14hr    36637 embryo 14-16hr    20617 embryo 16-18hr    27061 embryo 18-20hr    18668 embryo 20-22hr    22971 embryo 22-24hr    32050 larva L1    24735 larva L2    41846 larva L3 12hr old    36995 larva L3 puffstage 1-2    41925 larva L3 puffstage 3-6    39316 larva L3 puffstage 7-9    62563 white prepupae new    57658 white prepupae 12hr    42425 white prepupae 24hr    40241 pupae 2d postWPP    30360 pupae 3d postWPP    20892 pupae 4d postWPP    12937 adult male 01day    10558 adult male 05day    8873 adult male 30day    7696 adult female 01day    14350 adult female 05day    31809 adult female 30day    29487 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011726 expression level Developmental Stage   Expression Level embryo 00-02hr    35899 embryo 02-04hr    56257 embryo 04-06hr    71419 embryo 06-08hr    38869 embryo 08-10hr    35442 embryo 10-12hr    35262 embryo 12-14hr    36637 embryo 14-16hr    20617 embryo 16-18hr    27061 embryo 18-20hr    18668 embryo 20-22hr    22971 embryo 22-24hr    32050 larva L1    24735 larva L2    41846 larva L3 12hr old    36995 larva L3 puffstage 1-2    41925 larva L3 puffstage 3-6    39316 larva L3 puffstage 7-9    62563 white prepupae new    57658 white prepupae 12hr    42425 white prepupae 24hr    40241 pupae 2d postWPP    30360 pupae 3d postWPP    20892 pupae 4d postWPP    12937 adult male 01day    10558 adult male 05day    8873 adult male 30day    7696 adult female 01day    14350 adult female 05day    31809 adult female 30day    29487 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (35899) embryo 02-04hr  (56257) embryo 04-06hr  (71419) embryo 06-08hr  (38869) embryo 08-10hr  (35442) embryo 10-12hr  (35262) embryo 12-14hr  (36637) embryo 14-16hr  (20617) embryo 16-18hr  (27061) embryo 18-20hr  (18668) embryo 20-22hr  (22971) embryo 22-24hr  (32050) larva L1  (24735) larva L2  (41846) larva L3 12hr old  (36995) larva L3 puffstage 1-2  (41925) larva L3 puffstage 3-6  (39316) larva L3 puffstage 7-9  (62563) white prepupae new  (57658) white prepupae 12hr  (42425) white prepupae 24hr  (40241) pupae 2d postWPP  (30360) pupae 3d postWPP  (20892) pupae 4d postWPP  (12937) adult male 01day  (10558) adult male 05day  (8873) adult male 30day  (7696) adult female 01day  (14350) adult female 05day  (31809) adult female 30day  (29487) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35899) embryo 02-04hr  (56257) embryo 04-06hr  (71419) embryo 06-08hr  (38869) embryo 08-10hr  (35442) embryo 10-12hr  (35262) embryo 12-14hr  (36637) embryo 14-16hr  (20617) embryo 16-18hr  (27061) embryo 18-20hr  (18668) embryo 20-22hr  (22971) embryo 22-24hr  (32050) larva L1  (24735) larva L2  (41846) larva L3 12hr old  (36995) larva L3 puffstage 1-2  (41925) larva L3 puffstage 3-6  (39316) larva L3 puffstage 7-9  (62563) white prepupae new  (57658) white prepupae 12hr  (42425) white prepupae 24hr  (40241) pupae 2d postWPP  (30360) pupae 3d postWPP  (20892) pupae 4d postWPP  (12937) adult male 01day  (10558) adult male 05day  (8873) adult male 30day  (7696) adult female 01day  (14350) adult female 05day  (31809) adult female 30day  (29487) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (35899) embryo 02-04hr  (56257) embryo 04-06hr  (71419) embryo 06-08hr  (38869) embryo 08-10hr  (35442) embryo 10-12hr  (35262) embryo 12-14hr  (36637) embryo 14-16hr  (20617) embryo 16-18hr  (27061) embryo 18-20hr  18668 embryo 20-22hr  (22971) embryo 22-24hr  (32050) larva L1  (24735) larva L2  (41846) larva L3 12hr old  (36995) larva L3 puffstage 1-2  (41925) larva L3 puffstage 3-6  (39316) larva L3 puffstage 7-9  (62563) white prepupae new  (57658) white prepupae 12hr  (42425) white prepupae 24hr  (40241) pupae 2d postWPP  (30360) pupae 3d postWPP  (20892) pupae 4d postWPP  12937 adult male 01day  10558 adult male 05day    8873 adult male 30day    7696 adult female 01day  14350 adult female 05day  (31809) adult female 30day  (29487) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35899 embryo 02-04hr    56257 embryo 04-06hr    71419 embryo 06-08hr    38869 embryo 08-10hr    35442 embryo 10-12hr    35262 embryo 12-14hr    36637 embryo 14-16hr    20617 embryo 16-18hr    27061 embryo 18-20hr    18668 embryo 20-22hr    22971 embryo 22-24hr    32050 larva L1    24735 larva L2    41846 larva L3 12hr old    36995 larva L3 puffstage 1-2    41925 larva L3 puffstage 3-6    39316 larva L3 puffstage 7-9    62563 white prepupae new    57658 white prepupae 12hr    42425 white prepupae 24hr    40241 pupae 2d postWPP    30360 pupae 3d postWPP    20892 pupae 4d postWPP    12937 adult male 01day    10558 adult male 05day    8873 adult male 30day    7696 adult female 01day    14350 adult female 05day    31809 adult female 30day    29487 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011726    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011726 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011726 expression level Tissue   Expression Level Larval Central Nervous System    2840.975 Larval Midgut    5587.7 Larval Hindgut    4301.9 Larval Malpighian Tubules    4795.2 Larval Fat Body    4343.1 Larval Salivary Gland    6309.4 Larval Trachea    5470.6 Larval Carcass    5110.95 Adult Head    2145.4 Adult Eye    2112.925 Adult Brain    1123.1 Adult Thoracic-Abdominal Ganglion    1478.4 Adult Crop    5400.7 Adult Midgut    5227.2 Adult Hindgut    4103.1 Adult Malpighian Tubules    3418.6 Adult Fat Body    1977.3 Adult Salivary Gland    3599.7 Adult Heart    3642.025 Adult VirginFemale Spermatheca    2659.3 Adult InseminatedFemale Spermatheca    2842.5 Adult Ovary    3258.8 Adult Testis    1522.3 Adult Male Accessory Gland    2932.2 Adult Carcass    2420.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2840.975) Larval Midgut  (5587.7) Larval Hindgut  (4301.9) Larval Malpighian Tubules  (4795.2) Larval Fat Body  (4343.1) Larval Salivary Gland  (6309.4) Larval Trachea  (5470.6) Larval Carcass  (5110.95) Adult Head  (2145.4) Adult Eye  (2112.925) Adult Brain  (1123.1) Adult Thoracic-Abdominal Ganglion  (1478.4) Adult Crop  (5400.7) Adult Midgut  (5227.2) Adult Hindgut  (4103.1) Adult Malpighian Tubules  (3418.6) Adult Fat Body  (1977.3) Adult Salivary Gland  (3599.7) Adult Heart  (3642.025) Adult VirginFemale Spermatheca  (2659.3) Adult InseminatedFemale Spermatheca  (2842.5) Adult Ovary  (3258.8) Adult Testis  (1522.3) Adult Male Accessory Gland  (2932.2) Adult Carcass  (2420.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2840.975) Larval Midgut  (5587.7) Larval Hindgut  (4301.9) Larval Malpighian Tubules  (4795.2) Larval Fat Body  (4343.1) Larval Salivary Gland  (6309.4) Larval Trachea  (5470.6) Larval Carcass  (5110.95) Adult Head  (2145.4) Adult Eye  (2112.925) Adult Brain  (1123.1) Adult Thoracic-Abdominal Ganglion  (1478.4) Adult Crop  (5400.7) Adult Midgut  (5227.2) Adult Hindgut  (4103.1) Adult Malpighian Tubules  (3418.6) Adult Fat Body  (1977.3) Adult Salivary Gland  (3599.7) Adult Heart  (3642.025) Adult VirginFemale Spermatheca  (2659.3) Adult InseminatedFemale Spermatheca  (2842.5) Adult Ovary  (3258.8) Adult Testis  (1522.3) Adult Male Accessory Gland  (2932.2) Adult Carcass  (2420.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2840.975 Larval Midgut    5587.7 Larval Hindgut    4301.9 Larval Malpighian Tubules    4795.2 Larval Fat Body    4343.1 Larval Salivary Gland    6309.4 Larval Trachea    5470.6 Larval Carcass    5110.95 Adult Head    2145.4 Adult Eye    2112.925 Adult Brain    1123.1 Adult Thoracic-Abdominal Ganglion    1478.4 Adult Crop    5400.7 Adult Midgut    5227.2 Adult Hindgut    4103.1 Adult Malpighian Tubules    3418.6 Adult Fat Body    1977.3 Adult Salivary Gland    3599.7 Adult Heart    3642.025 Adult VirginFemale Spermatheca    2659.3 Adult InseminatedFemale Spermatheca    2842.5 Adult Ovary    3258.8 Adult Testis    1522.3 Adult Male Accessory Gland    2932.2 Adult Carcass    2420.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011726 expression level Tissue   Expression Level Larval Central Nervous System    2840.975 Larval Midgut    5587.7 Larval Hindgut    4301.9 Larval Malpighian Tubules    4795.2 Larval Fat Body    4343.1 Larval Salivary Gland    6309.4 Larval Trachea    5470.6 Larval Carcass    5110.95 Adult Head    2145.4 Adult Eye    2112.925 Adult Brain    1123.1 Adult Thoracic-Abdominal Ganglion    1478.4 Adult Crop    5400.7 Adult Midgut    5227.2 Adult Hindgut    4103.1 Adult Malpighian Tubules    3418.6 Adult Fat Body    1977.3 Adult Salivary Gland    3599.7 Adult Heart    3642.025 Adult VirginFemale Spermatheca    2659.3 Adult InseminatedFemale Spermatheca    2842.5 Adult Ovary    3258.8 Adult Testis    1522.3 Adult Male Accessory Gland    2932.2 Adult Carcass    2420.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2840.975) Larval Midgut  (5587.7) Larval Hindgut  (4301.9) Larval Malpighian Tubules  (4795.2) Larval Fat Body  (4343.1) Larval Salivary Gland  (6309.4) Larval Trachea  (5470.6) Larval Carcass  (5110.95) Adult Head  (2145.4) Adult Eye  (2112.925) Adult Brain  (1123.1) Adult Thoracic-Abdominal Ganglion  (1478.4) Adult Crop  (5400.7) Adult Midgut  (5227.2) Adult Hindgut  (4103.1) Adult Malpighian Tubules  (3418.6) Adult Fat Body  (1977.3) Adult Salivary Gland  (3599.7) Adult Heart  (3642.025) Adult VirginFemale Spermatheca  (2659.3) Adult InseminatedFemale Spermatheca  (2842.5) Adult Ovary  (3258.8) Adult Testis  (1522.3) Adult Male Accessory Gland  (2932.2) Adult Carcass  (2420.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2840.975) Larval Midgut  (5587.7) Larval Hindgut  (4301.9) Larval Malpighian Tubules  (4795.2) Larval Fat Body  (4343.1) Larval Salivary Gland  (6309.4) Larval Trachea  (5470.6) Larval Carcass  (5110.95) Adult Head  (2145.4) Adult Eye  (2112.925) Adult Brain  1123.1 Adult Thoracic-Abdominal Ganglion  1478.4 Adult Crop  (5400.7) Adult Midgut  (5227.2) Adult Hindgut  (4103.1) Adult Malpighian Tubules  (3418.6) Adult Fat Body  (1977.3) Adult Salivary Gland  (3599.7) Adult Heart  (3642.025) Adult VirginFemale Spermatheca  (2659.3) Adult InseminatedFemale Spermatheca  (2842.5) Adult Ovary  (3258.8) Adult Testis  1522.3 Adult Male Accessory Gland  (2932.2) Adult Carcass  (2420.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2840.975 Larval Midgut    5587.7 Larval Hindgut    4301.9 Larval Malpighian Tubules    4795.2 Larval Fat Body    4343.1 Larval Salivary Gland    6309.4 Larval Trachea    5470.6 Larval Carcass    5110.95 Adult Head    2145.4 Adult Eye    2112.925 Adult Brain    1123.1 Adult Thoracic-Abdominal Ganglion    1478.4 Adult Crop    5400.7 Adult Midgut    5227.2 Adult Hindgut    4103.1 Adult Malpighian Tubules    3418.6 Adult Fat Body    1977.3 Adult Salivary Gland    3599.7 Adult Heart    3642.025 Adult VirginFemale Spermatheca    2659.3 Adult InseminatedFemale Spermatheca    2842.5 Adult Ovary    3258.8 Adult Testis    1522.3 Adult Male Accessory Gland    2932.2 Adult Carcass    2420.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2145.4   NA  Eye    2112.925   NA  Brain    1123.1   2840.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1478.4   NA  Crop    5400.7   5587.7  Midgut    5227.2   4301.9  Hindgut    4103.1   4795.2  Malpighian Tubules    3418.6   4343.1  Fat Body    1977.3   6309.4  Salivary Gland    3599.7   NA  Heart    3642.025   5470.6  Trachea    NA   NA  VirginFemale Spermatheca    2659.3   NA  InseminatedFemale Spermatheca    2842.5   NA  Ovary    3258.8   NA  Testis    1522.3   NA  Male Accessory Gland    2932.2   5110.95  Carcass    2420.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011726 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4254-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal tsr76E tsr99E tsr100A tsr110M tsrCC01393 lethal | first instar larval stage tsrΔ96 lethal | larval stage tsrΔ96 lethal | larval stage | heat sensitive, with tsr139.cBa tsrΔ96 lethal | larval stage | heat sensitive, with tsr139.cBa, tsrV27Q.cBa tsrΔ96 lethal | larval stage | heat sensitive, with tsrV27Q.cBa tsrΔ96 lethal | larval stage | heat sensitive, with tsrV27Q.cBa/tsrΔ96 tsr139.cBa lethal | larval stage | heat sensitive, with tsrΔ96 tsr139.cBa tsrV27Q.cBa lethal | larval stage | heat sensitive, with tsrΔ96, tsr139.cBa tsrV27Q.cBa lethal | larval stage | heat sensitive, with tsrΔ96, tsrV27Q.cBa tsr139.cBa lethal | larval stage | heat sensitive (with tsr139.cBa) tsrΔ96 lethal | larval stage | heat sensitive (with tsrV27Q.cBa) tsrΔ96 lethal | larval stage | heat sensitive (with tsrV27Q.cBa), with tsr139.cBa tsrΔ96 lethal | larval stage | heat sensitive (with tsrΔ96) tsr139.cBa tsrV27Q.cBa lethal | larval stage | heat sensitive (with tsrΔ96), with tsr139.cBa tsrV27Q.cBa lethal | pupal stage tsr1 lethal | pupal stage (with tsr1) tsr2 lethal | pupal stage (with tsr2) tsr1 lethal | pupal stage | cold sensitive, with tsr139.cBa tsrΔ96 lethal | pupal stage | cold sensitive, with tsrV27Q.cBa tsrΔ96 lethal | pupal stage | cold sensitive, with tsrΔ96 tsr139.cBa tsrV27Q.cBa lethal | pupal stage | cold sensitive (with tsr139.cBa) tsrΔ96 lethal | pupal stage | cold sensitive (with tsrV27Q.cBa) tsrΔ96 lethal | pupal stage | cold sensitive (with tsrΔ96) tsr139.cBa tsrV27Q.cBa lethal | pupal stage | heat sensitive, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 lethal | pupal stage | heat sensitive, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa lethal | pupal stage | heat sensitive, with tsr139.cBa tsrV27Q.cBa lethal | pupal stage | heat sensitive, with tsrV27Q.cBa tsr139.cBa lethal | pupal stage | heat sensitive (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 lethal | pupal stage | heat sensitive (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa lethal | recessive tsr1 tsr2 tsrk00508 tsrk01208 tsrk03101 tsrk05403 tsrk05419b tsrk05633 tsrk09317 tsrk12103 tsrk13409 tsrk16304 semi-lethal | heat sensitive tsr2 semi-lethal | pupal stage tsrntf semi-viable (with tsr1) tsrntf semi-viable (with tsrntf) tsr1 viable (with tsr2) tsrntf viable (with tsrntf) tsr2 viable | cold sensitive, with tsr139.cBa tsrV27Q.cBa viable | cold sensitive, with tsr139.cBa, tsrV27Q.cBa tsrΔ96 viable | cold sensitive, with tsrV27Q.cBa tsr139.cBa viable | cold sensitive, with tsrV27Q.cBa/tsrΔ96 tsr139.cBa viable | cold sensitive, with tsrΔ96, tsr139.cBa tsrV27Q.cBa viable | cold sensitive, with tsrΔ96, tsrV27Q.cBa tsr139.cBa viable | cold sensitive (with tsrV27Q.cBa), with tsr139.cBa tsrΔ96 viable | cold sensitive (with tsrΔ96), with tsr139.cBa tsrV27Q.cBa Sterility Allele female sterile (with tsr1) tsrntf female sterile (with tsr2) tsrntf female sterile (with tsrntf) tsr1 tsr2 male fertile | partially (with tsr2) tsrntf male fertile | partially (with tsrntf) tsr2 male sterile tsr2 male sterile | heat sensitive (with tsr1) tsrntf male sterile | heat sensitive (with tsrntf) tsr1 sterile tsrntf Other Phenotypes Allele cell polarity defective, with tsr139.cBa, tsrV27Q.cBa tsrΔ96 cell polarity defective, with tsrhs.PB tsrΔ96 cell polarity defective, with tsrV27Q.cBa/tsrΔ96 tsr139.cBa cell polarity defective, with tsrΔ96 tsrhs.PB cell polarity defective, with tsrΔ96, tsr139.cBa tsrV27Q.cBa cell polarity defective, with tsrΔ96, tsrV27Q.cBa tsr139.cBa cell polarity defective (with tsrhs.PB) tsrΔ96 cell polarity defective (with tsrV27Q.cBa), with tsr139.cBa tsrΔ96 cell polarity defective (with tsrΔ96) tsrhs.PB cell polarity defective (with tsrΔ96), with tsr139.cBa tsrV27Q.cBa cytokinesis defective tsrdsRNA.13-629 neuroanatomy defective, with Scer\GAL4109(2)80 tsrScer\UAS.cNa neuroanatomy defective | somatic clone tsrLL01333 tsrLL02200 tsrN96A tsrN121 visible | somatic clone tsrN121 wild-type tsr+t6.4 Phenotype manifest in Allele actin cytoskeleton & eye disc | somatic clone tsrk05633 actin filament | heat sensitive tsrntf actomyosin contractile ring tsrdsRNA.13-629 adult abdominal sensillum, with tsrhs.PB tsrΔ96 adult abdominal sensillum, with tsrΔ96 tsrhs.PB adult abdominal sensillum (with tsrhs.PB) tsrΔ96 adult abdominal sensillum (with tsrΔ96) tsrhs.PB adult mushroom body & axon | somatic clone tsrN121 tsrN96A adult mushroom body | somatic clone tsrN121 tsrN96A aster & primary spermatocyte cyst tsr1 tsr2 aster & secondary spermatocyte tsr1 tsr2 border follicle cell | heat sensitive (with tsr1) tsrntf border follicle cell | heat sensitive (with tsrntf) tsr1 bract, with tsrhs.PB tsrΔ96 bract, with tsrΔ96 tsrhs.PB bract (with tsrhs.PB) tsrΔ96 bract (with tsrΔ96) tsrhs.PB chaeta tsrntf dendrite, with Scer\GAL4109(2)80 tsrScer\UAS.cNa eye, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 eye, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa eye (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 eye (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa eye | somatic clone tsrk05633 filamentous actin | somatic clone tsrN121 follicle cell & actin filament | ectopic | somatic clone tsrunspecified follicle cell | somatic clone tsrunspecified imaginal disc tsrk01208 lamina, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 lamina, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa lamina (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 lamina (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa leg sensillum, with tsrhs.PB tsrΔ96 leg sensillum, with tsrΔ96 tsrhs.PB leg sensillum (with tsrhs.PB) tsrΔ96 leg sensillum (with tsrΔ96) tsrhs.PB meiotic prophase I tsr1 tsr2 meiotic prophase II tsr1 tsr2 microchaeta, with tsr139.cBa, tsrV27Q.cBa tsrΔ96 microchaeta, with tsrΔ96, tsr139.cBa tsrV27Q.cBa microchaeta, with tsrΔ96, tsrV27Q.cBa tsr139.cBa microchaeta (with tsrV27Q.cBa) tsrΔ96 microchaeta (with tsrΔ96) tsrV27Q.cBa mushroom body | somatic clone tsrLL01333 tsrLL02200 Nebenkern tsr1 tsr2 nurse cell & nucleus (with tsr1) tsrntf nurse cell & nucleus (with tsrntf) tsr1 ommatidium, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 ommatidium, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa ommatidium, with tsrhs.PB tsrΔ96 ommatidium, with tsrΔ96 tsrhs.PB ommatidium (with tsrhs.PB) tsrΔ96 ommatidium (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 ommatidium (with tsrΔ96) tsrhs.PB ommatidium (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa ommatidium | somatic clone tsrk05633 oocyte & actin filament | ectopic | germ-line clone tsr1 tsr2 optic lobe, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 optic lobe, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa optic lobe (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 optic lobe (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa ovary | heat sensitive tsrntf retina, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 retina, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa retina (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 retina (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa rhabdomere, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 rhabdomere, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa rhabdomere (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 rhabdomere (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa rhabdomere | somatic clone tsrk05633 rhabdomere membrane, with Scer\GAL4GMR.Pc, tsrScer\UAS.cPa tsrΔ96 rhabdomere membrane, with Scer\GAL4GMR.Pc, tsrΔ96 tsrScer\UAS.cPa rhabdomere membrane (with tsrScer\UAS.cPa), with Scer\GAL4GMR.Pc tsrΔ96 rhabdomere membrane (with tsrΔ96), with Scer\GAL4GMR.Pc tsrScer\UAS.cPa spermatid tsr1 tsr2 spermatocyte fusome tsr1 spermatocyte ring canal tsr1 terminal filament | heat sensitive tsrntf wing & filamentous actin, with tsr139.cBa, tsrV27Q.cBa tsrΔ96 wing & filamentous actin, with tsrΔ96, tsr139.cBa tsrV27Q.cBa wing & filamentous actin, with tsrΔ96, tsrV27Q.cBa tsr139.cBa wing & filamentous actin (with tsrV27Q.cBa) tsrΔ96 wing & filamentous actin (with tsrΔ96) tsrV27Q.cBa wing hair, with tsr139.cBa, tsrV27Q.cBa tsrΔ96 wing hair, with tsrhs.PB tsrΔ96 wing hair, with tsrΔ96 tsrhs.PB wing hair, with tsrΔ96, tsr139.cBa tsrV27Q.cBa wing hair, with tsrΔ96, tsrV27Q.cBa tsr139.cBa wing hair (with tsrhs.PB) tsrΔ96 wing hair (with tsrV27Q.cBa) tsrΔ96 wing hair (with tsrΔ96) tsrV27Q.cBa tsrhs.PB wing hair | somatic clone tsrN121
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of tsr Class Mutagen Stocks Known lesion tsrEY16043 P-element activity 2 -- tsrk05633 P-element activity 2 -- tsr1 P-element activity 1 Yes tsr5-SZ-3356 1 -- tsrc05308 piggyBac transposase 1 -- tsrd05545 P-element activity 1 -- tsrDG24312 1 -- tsrEY11205 P-element activity 1 -- tsrf06853 piggyBac transposase 1 -- tsrk00508 P-element activity 1 -- tsrk01208 P-element activity 1 -- tsrk03101 P-element activity 1 -- tsrk05403 P-element activity 1 -- tsrk13409 P-element activity 1 -- tsrk16304 P-element activity 1 -- tsrLL01333 1 Yes tsrN121 loss of function allele P-element activity 1 Yes tsrN96A loss of function allele P-element activity 1 Yes tsrNP3184 1 -- tsr00026 P-element activity 0 -- tsr100A ethyl methanesulfonate 0 Yes tsr110M ethyl methanesulfonate 0 Yes tsr2 P-element activity 0 Yes tsr76E ethyl methanesulfonate 0 Yes tsr99E ethyl methanesulfonate 0 Yes tsrCC01393 P-element activity 0 Yes tsrCPTI002237 piggyBac transposase 0 Yes tsrk05419b P-element activity 0 -- tsrk09317 P-element activity 0 -- tsrk12103 P-element activity 0 -- tsrLL02200 0 Yes tsrntf 0 Yes tsrunspecified 0 -- tsrΔ96 loss of function allele 0 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tsr Class Mutagen Stocks Known lesion tsrS3A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 2 Yes tsrS3E.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 2 Yes tsrScer\UAS.cNa in vitro construct - regulatory fusion 2 Yes tsrHMS00534 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes tsr+t6.4 in vitro construct - genomic fragment 0 Yes tsr139.cBa in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes tsrdsRNA.13-629 in vitro construct - RNAi 0 Yes tsrGD12410 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes tsrhs.PB in vitro construct - regulatory fusion 0 Yes tsrKK108706 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes tsrS3A.cA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes tsrScer\UAS.cAa in vitro construct - regulatory fusion 0 Yes tsrScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes tsrScer\UAS.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes tsrV27Q.cBa in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)2651ex3 (Chen et al., 2001) Df(2R)Exel6081 (Ryder, 2004.4.26) Df(2R)or-BR6 (Gunsalus et al., 1995) Df(2R)or-BR11 (Spradling et al., 1999, Chen et al., 2001, BDGP Project Members, 1994-1999, Gunsalus et al., 1995)
Not disrupted in	Df(2R)bwVDe2LPxKR (Spradling et al., 1999, BDGP Project Members, 1994-1999, Beaton, 1997.12.27) Df(2R)bw-S46 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Gunsalus et al., 1995) Df(2R)Px2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) In(2LR)ltG10LBR27R (BDGP Project Members, 1994-1999, Gunsalus et al., 1995) In(2LR)Px4 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12410} NA P{KK108706} NA P{TRiP.HMS00534} NA P{tsrUAS} NA P{UAS-cofilin.A} NA P{UAS-cofilin.S3A} NA P{UAS-tsr.His} NA P{UAS-tsr.N} NA P{UAS-tsr.S3A} NA P{UAS-tsr.S3E} NA heat-shock construct P{tsr.WHTG} NA characterization construct P{tsr.139} NA P{tsr.V27Q} NA P{tsr+.RS6.4} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{A92}tsr1 No P{lacW}l(2)SH0343SH0343 No P{lacW}tsr2 No P{lacW}tsrk00508 No P{lacW}tsrk01208 No P{lacW}tsrk03101 No P{lacW}tsrk05403 No P{lacW}tsrk05419b No P{lacW}tsrk05633 No P{lacW}tsrk09317 No P{lacW}tsrk12103 No P{lacW}tsrk13409 No P{lacW}tsrk16304 No P{PZ}tsr00026 No insertion of mobile activating element P{EPgy2}tsrEY11205 NA P{EPgy2}tsrEY16043 NA P{XP}tsrd05545 NA miscellaneous insertions gypsy{}tsrntf NA P{PTT-GC}tsrCC01393 NA P{RS5}tsr5-SZ-3356 NA P{wHy}tsrDG24312 NA PBac{754.P.FSVS-0}tsrCPTI002237 NA PBac{PB}tsrc05308 NA PBac{SAstopDsRed}tsrLL01333 NA PBac{SAstopDsRed}tsrLL02200 NA PBac{WH}tsrf06853 NA insertion of enhancer trap binary system P{GawB}tsrNP3184 No
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
actin binding inferred from mutant phenotype AND inferred from sequence or structural similarity with human CFL1 AND inferred from sequence or structural similarity with Saccharomyces COF1 (Edwards et al., 1994)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Baum and Perrimon, 2001, Kiger et al., 2003, Medina et al., 2008) actin filament polymerization inferred from mutant phenotype (Rogers et al., 2003) axonogenesis inferred from mutant phenotype (Ng and Luo, 2004) border follicle cell migration inferred from mutant phenotype (Chen et al., 2001) cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) compound eye development inferred from genetic interaction with mbt (Menzel et al., 2007) compound eye morphogenesis inferred from mutant phenotype (Pham et al., 2008) cytokinesis inferred from mutant phenotype (Kiger et al., 2003, Echard et al., 2004, Somma et al., 2002) establishment of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Blair et al., 2006) establishment of ommatidial planar polarity inferred from mutant phenotype (Blair et al., 2006) establishment of planar polarity inferred from mutant phenotype (Blair et al., 2006) female gonad development inferred from mutant phenotype (Chen et al., 2001) imaginal disc-derived leg segmentation inferred from mutant phenotype (Blair et al., 2006) mushroom body development inferred from mutant phenotype (Ng and Luo, 2004) regulation of lamellipodium assembly inferred from mutant phenotype (Iwasa and Mullins, 2007) rhabdomere development inferred from mutant phenotype (Pham et al., 2008)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) non-traceable author statement (Swiss-Prot Project Members, 1995.9.1)
Biological Process
CV term Evidence References
actin filament depolymerization non-traceable author statement (Edwards, 1994.3.30) cytokinesis, actomyosin contractile ring assembly traceable author statement (Mazumdar and Mazumdar, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tsr allele Gene References tsrk05633 twf (Wahlstrom et al., 2001) tsrS3A.Scer\UAS LIMK1 (Ng and Luo, 2004) Pak (Ng and Luo, 2004) ssh (Ng and Luo, 2004) tsrScer\UAS.cNa LIMK1 (Ng and Luo, 2004) Pak (Ng and Luo, 2004) ssh (Ng and Luo, 2004) unspecified Btk29A (Chandrasekaran and Beckendorf, 2005) LIMK1 (Ang et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63422 DroID - A comprehensive database of gene and protein interactions. • FBgn0011726 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37841
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13484 Dere\GG19959 Dmoj\GI20679 Dper\GL10428 Dpse\GA18060 Dsec\GM18279 Dsim\GD24977 Dwil\GK10641 Dyak\tsr
Curated drosophilid orthologs	Dpse\GA18060   Dsan\tsr   Dyak\tsr
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003957-PA Aedes aegypti (mosquito) AGAP012056-PA Anopheles gambiae (mosquito) XP_001120072.1 Apis mellifera (honey bee) NP_001119642.1 Acyrthosiphon pisum (pea aphid) At5g59890.1 Arabidopsis thaliana (wall cress) 87998 Batrachochytrium dendrobatidis (chytrid fungus) 283554 Branchiostoma floridae (lancelet) 67392 Branchiostoma floridae (lancelet) 81123 Branchiostoma floridae (lancelet) XP_001896055.1 Brugia malayi (roundworm nematode) BGIBMGA000129-PA Bombyx mori (silk worm) ENSBTAP00000020036 Bos taurus (bovine) ENSBTAP00000020512 Bos taurus (bovine) CAF0006915 Candida albicans (a form of yeast) CBP33574 Caenorhabditis briggsae (nematode) CE31893 Caenorhabditis elegans (worm) ENSCAFP00000019576 Canis familiaris (dog) CAGL0E04048g Candida glabrata (haploid yeast) Chro.50095 Cryptosporidium hominis (obligate parasite) JA03385 Caenorhabditis japonica (nematode) CMN147C Cyanidioschyzon merolae (red alga) cn03122 Cryptococcus neoformans (yeast-like fungus) cgd5_2800 Cryptosporidium parvum (protozoan parasite) CPIJ006194 Culex pipens (mosquito) ENSCPOP00000008080 Cavia porcellus (guinea pig) RP35569 Caenorhabditis remanei (nematode) 221112 Capitella spl (polychaete worm) DDB0201631 Dictyostelium discoideum (amoeba) DDB0214987 Dictyostelium discoideum (amoeba) DEHA2B07722g Debaryomyces Hansenii (yeast) 309155 Daphnia pulex (daphnia) ENSDARP00000023177 Danio rerio (zebra fish) ENSECAP00000017389 Equus caballus (horse) XP_651689 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005461 Gymnopilus aculeatus (mushroom) ENSGALP00000014097 Gallus gallus (chicken) 160072 Hypsipyla robusta (cedar shoot borer) ENSP00000246069 Homo sapiens (human) ENSP00000309629 Homo sapiens (human) ENSP00000340635 Homo sapiens (human) ISCW006326-PA Ixodes scapularis (deer tick) KLLA0E00463g Kluyveromyces lactis (yeast) 164500 Lottia gigantea (owl limpet) LmjF29.0510 Leishmania major (virus) 8986 Monocosta brevicollis (choanoflagellate) ENSMODP00000006703 Monodelphis domestica (gray opossum) ENSMODP00000006706 Monodelphis domestica (gray opossum) ENSMODP00000016202 Monodelphis domestica (gray opossum) ENSMMUP00000024101 Macaca mulatta (rhesus monkey) ENSMUSP00000099461 Mus musculus (house mouse) 236760 Nematostella vectensis (starlet anemone) XP_001602492.1 Nasonia vitripennis (wasp) ENSOANP00000001984 Ornithorynchus anatinus (platypus) ENSOANP00000022154 Ornithorynchus anatinus (platypus) ENSORLP00000014864 Oryzias latipes (japanese killifish) LOC_Os02g44470.1 Oryza sativa (asian rice) PF13_0326 Plasmodium falciparum (protozoal parasite) PHUM004965-PA Pediculus humanus (human body louse) PP17095 Pristionchus pacificus (nematode) 221707 Physcomitrella patens (moss) ENSPPYP00000006519 Pongo pygmaeus (orangutan) ENSPPYP00000011991 Pongo pygmaeus (orangutan) 79782 Phytophthora ramorum (sudden oak death pathogen) 155603 Phytophthora sojae (root rot pathogen) 640513 Populus trichocarpa (black cottonwood) ENSPTRP00000004744 Pan troglodytes (chimpanzee) ENSPTRP00000010616 Pan troglodytes (chimpanzee) ENSPTRP00000022766 Pan troglodytes (chimpanzee) PVX_115030 Plasmodium vivax (protozoal parasite) ENSRNOP00000000975 Rattus norvegicus (norway rat) ENSRNOP00000007794 Rattus norvegicus (norway rat) ENSRNOP00000008229 Rattus norvegicus (norway rat) ENSRNOP00000035048 Rattus norvegicus (norway rat) 147069 Sorghum bicolor (sorghum) 4893658 Sorghum bicolor (sorghum) YLL050C Saccharomyces cerevisiae (budding yeast) Smp_120700.1 Schistosoma mansoni (trematode parasite) SPAC20G4.06c Schizosaccharomyces pombe (fission yeast) XP_001189287.1 Strongylocentrotus purpuratus (purple sea urchin) 57086 Trichoplax adhaerens (metazoa) XP_968178.1 Tribolium castaneum (red flour beetle) Tc00.1047053508411.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510145.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003347 Tetraodon nigroviridis (green spotted pufferfish) 4830 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019380 Takifugu rubripes (pufferfish Takifugu) 134.m00094 Tetrahymena thermophila (ciliate protozoa) 86673.m00308 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006568 Xenopus tropicalis (frog) YALI0F20856g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11052 LH24307 ISCW006326 FBgn0064246 FBgn0212654 FBgn0209017 FBgn0196290 FBgn0173186 JGI_V11_309155 FBgn0078068 FBgn0148038 FBgn0143414 FBgn0112159 FBgn0090513 CPIJ015839 CPIJ006194 BGIBMGA000129 ACYPI000058 GB18917 AGAP012056 AAEL003957 PB25963 PHUM164690 GLEAN_01574
Stocks & Reagents
Stocks Listed in FlyBase ( 28 )
Bloomington	20665 y1 w67c23; P{EPgy2}tsrEY11205 9109 w*; P{FRT(whs)}G13 tsrN121/CyO 12201 y1 w67c23; P{lacW}tsrk05633/CyO 9234 P{UAS-tsr.N}1.7, y1 w*; Pin1/CyO 21246 y1 w67c23; P{wHy}tsrDG24312/SM6a 33670 y1 sc* v1; P{TRiP.HMS00534}attP2 21181 y1 w67c23; P{EPgy2}tsrEY16043/CyO 9236 P{UAS-tsr.S3A}4.1, y1 w*; Pin1/CyO
Harvard	- P{XP}tsrd05545 - PBac{PB}tsrc05308 - PBac{WH}tsrf06853
Kyoto	126013 w1118; P{RS5}tsr5-SZ-3356
	More stocks available...
Genomic Clones ( 1 )
	BACR28M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 327 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP12293 LD06785
Other clones	yak-ad_tsr yak-em_tsr
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02325 GH11804 GH18979 GM01262 GM05382 GM12248 GM13866 GM15315 GM17481 GM23602 GM23641 GM25935 LD16430 LD24439 LD30447 LD46849 LP01133 LP02030 LP05481 LP10669 LP19346 RE03146 RE03371 RE03529 RE04257 RE05887 RE07957 RE08784 RE09310 RE09593 RE10832 RE11047 RE15744 RE16841 RE17561 RE17970 RE18082 RE18477 RE19241 RE20167 RE26670 RE27816 RE30788 RE31657 RE31741 RE31822 RE33690 RE36230 RE37956 RE38850 RE39221 RE41280 RE41662 RE43641 RE44911 RE45669 RE45757 RE46122 RE47422 RE49551 RE52191 RE53332 RE53724 RE61038 RE61705 RE64270 RE64482 RE65052 RE65689 RE65979 RE66903 RE69704 RE69866 RE71516 RE73933 RE74925 SD03547 SD11289 SD12102 SD12157 SD12243 SD12845 SD13987 SD14913 SD17250 SD17671 SD17882 SD19287 SD20679 SD20785 SD20796 SD20955 SD25276 SD25662 SD26171
Other clones	125182 190406 473510 473591 521739 522176 522303 522341 522473 522858 523420 524033 525050 525732 527788 528031 533953 542826 557118 557168 576480 bs45a10 CK01.5B.F3 CK01.6D.G4 CK01.26B.D10 Dmel_dig_000232_0628_0544 Dmel_dig_000458_0673_0533 Dmel_dig_000726_0686_0395 Dmel_dig_000867_0628_0329 Dmel_dig_002274_0584_1827 Dmel_dig_003225_0592_2024 Dmel_dig_004283_0585_1876 Dmel_dig_004381_0640_0525 Dmel_dig_004976_0685_2023 Dmel_dig_005343_0691_3502 Dmel_dig_005615_0707_2000 Dmel_dig_006201_0594_2470 Dmel_dig_006324_0662_2346 Dmel_dig_007924_0675_3172 Dmel_dig_008226_0641_3483 Dmel_dig_008255_0659_3512 Dmel_dig_008481_0661_2782 Dmel_dig_009248_0711_0924 Dmel_dig_013072_0663_2904 Dmel_dig_014468_0623_0388 Dmel_dig_015875_0689_3085 Dmel_dig_016036_0596_1104 Dmel_neb_012456_0907_2597 Dmel_neb_014685_0586_1171 EC00447 EC00847 EC01582 EC01805 EC13105 EC14028 EC14810 EC15107 EC22207 EC22976 EC27978 EC30420 EC30506 EC30807 EC34271 EC39580 EC40678 EK010144 EK025135 EK165105 EK247436 EK292761 EN00216 EN00318 EN00937 EN01516 EN01762 EN01843 EN02110 EN02918 EN03863 EN04406 EN04635 EN06424 EN07031 EN07940 EN08252 EN09609 EN10520 EN11426 EN12062 EN12164 FGA010D06 FGB002A03 FGC002D08 FGC007H01 FGC009D05 FGC014A04 FGC016D01 FGC019H06 FGC020F02 FGC021F07 FGC022G11 FGC024D08 FGC029B07 FGC032B05 FGC033A09 FGC033G01 FGH001B02 FGH001C05 FGH102F05 FGH102G02 FGH105F01 FGH112A08 FGH113B04 FGH115A03 FGH120C08 FGH122D08 FGH123E09 FGH125A03 FGH128H12 FGM101C05 FGM211C11 FGM213E07 FGM215C08 FGM227C05 FGM228A10 FGM235H07 FGM236A12 FGM303F09 RP003003292 RP003004698 RP003008857 RP003016179 RP003020559 RP003023944 RP003024148 RP003025490 RP003033841 RP003046504 RP003052872 RP003058628 RP003081676 RP003082471 RP003082489 RP003094149 RP003096544 RP003113987 RP003114610 RP003120279 RP003122601 RP003125124 RP003125832 RP003125958 RP003129672 RP003132274 RP003136211 RP003154755 RP003158586 RP003163480 RP003166569 RP003168493 RP003172182 RP003172362 RP003173359 RP003178792 RP003186202 RP003186742 RP003191344 RP003192588 RP003202855 RP003205230 RP003221171 RP003225175 RP003234388 RP003242967 RP003260236 RP003273406 RP003285906 RP003286171 RP003290050 RP003290840 RP003291966 RP003303065 RP003312726 RP003322693 RP003333256 RP003351816 RP003354827 RP003365396 RP003387161 RP003393111 RP003406290 RP003406875 RP003410850 RP003415615 RP003430222 RP003434191 RP003436119 RP003442883 RP003449373 RP003457761 RP003458381 RP003462206 RP003465477 RP003470514 RP003474643 RP003474839 RP003479308 RP003479501 RP003497572 RP003502526 RP003514849 RP003515979 RP003521992 RP003554875 RP003563571 RP003574523 RP003581259 RP003597242 RP003608139 RP003621929 RP003629560 RP003636442 RP003638908 RP003647383 RP003651533 RP003679113 SD03850
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011726 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37841
Antibody Information
	polyclonal (Jovceva et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tsr CG4254 (Wang, 1999.11)
Source for database merge of	Source for merge of: tsr l(2)k05633 (Spradling et al., 1999) Source for merge of: tsr ntf (Chen et al., 1999)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release. (Zhang et al., 2006) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) tsr regulates actin filament formation throughout the cell cortex in the follicular epithelium. (Baum and Perrimon, 2001) tsr is required for the formation of terminal filaments during larval development and is also required for the migration of border cells during oogenesis. (Chen et al., 2001) tsr mutants show disruption of terminal filament (TF) formation in the ovary. TF precursor cells can be seen scattered in a ring in the anterior region of late third larval instar tsr mutant ovaries. tsr is pupal lethal. (Chen et al., 1998) tsr is required for ovarian morphogenesis. (Chen et al., 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) tsr mutant spermatocytes exhibit abnormal positioning and delayed migration of asters to cell poles. (Giansanti et al., 1995) tsr has been cloned and characterised. (Gunsalus et al., 1995) Induced expression of tsr proteins in yeast causes aberrant cell shapes reflecting defects in cytokinesis and/or cell shape maintenance. (Edwards et al., 1994) tsr mutant spermatocytes exhibit abnormal positioning and delayed migration of asters to cell poles. tsr mutants also display a defect in cytokinesis (in mitosis and meiosis). (Gunsalus et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057686 RefSeq (Proteins) • NP_477034 DDBJ / EMBL / GenBank • AA803668 AAA19856 AAC46962 AAC46963 AAF47146 AC004642 AQ025765 CL868481 CZ469867 CZ474596 CZ489582 U08217 U24490 U24676 Entrez Gene - A searchable database of RefSeq genes. • 37841 UniProtKB/Swiss-Prot • P45594
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63422 DroID - A comprehensive database of gene and protein interactions. • FBgn0011726 DRSC - Results from RNAi screens. • FBgn0011726 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011726 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4254-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011726 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37841 InParanoid A subset of ortholog calls from InParanoid. • AAEL003957-PA Aedes aegypti (mosquito) AGAP012056-PA Anopheles gambiae (mosquito) XP_001120072.1 Apis mellifera (honey bee) NP_001119642.1 Acyrthosiphon pisum (pea aphid) At5g59890.1 Arabidopsis thaliana (wall cress) 87998 Batrachochytrium dendrobatidis (chytrid fungus) 283554 Branchiostoma floridae (lancelet) 67392 Branchiostoma floridae (lancelet) 81123 Branchiostoma floridae (lancelet) XP_001896055.1 Brugia malayi (roundworm nematode) BGIBMGA000129-PA Bombyx mori (silk worm) ENSBTAP00000020036 Bos taurus (bovine) ENSBTAP00000020512 Bos taurus (bovine) CAF0006915 Candida albicans (a form of yeast) CBP33574 Caenorhabditis briggsae (nematode) CE31893 Caenorhabditis elegans (worm) ENSCAFP00000019576 Canis familiaris (dog) CAGL0E04048g Candida glabrata (haploid yeast) Chro.50095 Cryptosporidium hominis (obligate parasite) JA03385 Caenorhabditis japonica (nematode) CMN147C Cyanidioschyzon merolae (red alga) cn03122 Cryptococcus neoformans (yeast-like fungus) cgd5_2800 Cryptosporidium parvum (protozoan parasite) CPIJ006194 Culex pipens (mosquito) ENSCPOP00000008080 Cavia porcellus (guinea pig) RP35569 Caenorhabditis remanei (nematode) 221112 Capitella spl (polychaete worm) DDB0201631 Dictyostelium discoideum (amoeba) DDB0214987 Dictyostelium discoideum (amoeba) DEHA2B07722g Debaryomyces Hansenii (yeast) 309155 Daphnia pulex (daphnia) ENSDARP00000023177 Danio rerio (zebra fish) ENSECAP00000017389 Equus caballus (horse) XP_651689 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005461 Gymnopilus aculeatus (mushroom) ENSGALP00000014097 Gallus gallus (chicken) 160072 Hypsipyla robusta (cedar shoot borer) ENSP00000246069 Homo sapiens (human) ENSP00000309629 Homo sapiens (human) ENSP00000340635 Homo sapiens (human) ISCW006326-PA Ixodes scapularis (deer tick) KLLA0E00463g Kluyveromyces lactis (yeast) 164500 Lottia gigantea (owl limpet) LmjF29.0510 Leishmania major (virus) 8986 Monocosta brevicollis (choanoflagellate) ENSMODP00000006703 Monodelphis domestica (gray opossum) ENSMODP00000006706 Monodelphis domestica (gray opossum) ENSMODP00000016202 Monodelphis domestica (gray opossum) ENSMMUP00000024101 Macaca mulatta (rhesus monkey) ENSMUSP00000099461 Mus musculus (house mouse) 236760 Nematostella vectensis (starlet anemone) XP_001602492.1 Nasonia vitripennis (wasp) ENSOANP00000001984 Ornithorynchus anatinus (platypus) ENSOANP00000022154 Ornithorynchus anatinus (platypus) ENSORLP00000014864 Oryzias latipes (japanese killifish) LOC_Os02g44470.1 Oryza sativa (asian rice) PF13_0326 Plasmodium falciparum (protozoal parasite) PHUM004965-PA Pediculus humanus (human body louse) PP17095 Pristionchus pacificus (nematode) 221707 Physcomitrella patens (moss) ENSPPYP00000006519 Pongo pygmaeus (orangutan) ENSPPYP00000011991 Pongo pygmaeus (orangutan) 79782 Phytophthora ramorum (sudden oak death pathogen) 155603 Phytophthora sojae (root rot pathogen) 640513 Populus trichocarpa (black cottonwood) ENSPTRP00000004744 Pan troglodytes (chimpanzee) ENSPTRP00000010616 Pan troglodytes (chimpanzee) ENSPTRP00000022766 Pan troglodytes (chimpanzee) PVX_115030 Plasmodium vivax (protozoal parasite) ENSRNOP00000000975 Rattus norvegicus (norway rat) ENSRNOP00000007794 Rattus norvegicus (norway rat) ENSRNOP00000008229 Rattus norvegicus (norway rat) ENSRNOP00000035048 Rattus norvegicus (norway rat) 147069 Sorghum bicolor (sorghum) 4893658 Sorghum bicolor (sorghum) YLL050C Saccharomyces cerevisiae (budding yeast) Smp_120700.1 Schistosoma mansoni (trematode parasite) SPAC20G4.06c Schizosaccharomyces pombe (fission yeast) XP_001189287.1 Strongylocentrotus purpuratus (purple sea urchin) 57086 Trichoplax adhaerens (metazoa) XP_968178.1 Tribolium castaneum (red flour beetle) Tc00.1047053508411.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510145.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003347 Tetraodon nigroviridis (green spotted pufferfish) 4830 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019380 Takifugu rubripes (pufferfish Takifugu) 134.m00094 Tetrahymena thermophila (ciliate protozoa) 86673.m00308 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006568 Xenopus tropicalis (frog) YALI0F20856g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/twinstar1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37841 modMine - Data generated by the modENCODE project. • FBgn0011726 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11052 LH24307 ISCW006326 FBgn0064246 FBgn0212654 FBgn0209017 FBgn0196290 FBgn0173186 JGI_V11_309155 FBgn0078068 FBgn0148038 FBgn0143414 FBgn0112159 FBgn0090513 CPIJ015839 CPIJ006194 BGIBMGA000129 ACYPI000058 GB18917 AGAP012056 AAEL003957 PB25963 PHUM164690 GLEAN_01574
Synonyms & Secondary IDs ( 28 )
Reported As
Symbol Synonym	12/8 (Roch et al., 1998) Adf (Rogers et al., 2003) ADF (Pham et al., 2008) ADF/cofilin (Petit et al., 2002) Cadf   CG4254 (Vierstraete et al., 2004, Goldstein and Gunawardena, 2000, Rogers et al., 2003, Quinones-Coello, 2007, Hughes et al., 2008, Monzo et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cammarato et al., 2011) cofilin (Rogers et al., 2005, Rogers et al., 2003) cofilin/actin depolymerizing factor homolog (Edwards, 1994.3.30) cofilin/ADF (Rorth, 2002) D61 (Edwards et al., 1994) D-cof (Ohashi et al., 2000, Medina et al., 2008) l(2)03101 (Kolhekar et al., 1997) l(2)k03101   l(2)k05633 (Beaton, 1997.12.27, BDGP Project Members, 1994-1999, ) l(2)k13409   ntf (Chen et al., 1999, Chen, 1998.3.12, Chen et al., 1998, ) T8 (Vierstraete et al., 2004) tsr (Janody and Treisman, 2006, Zhang et al., 2006, Blanco et al., 2010, Stuart et al., 2007, Zhang et al., 2006, Fernández et al., 2011, Buszczak et al., 2007, Quinones-Coello, 2007, Menzel et al., 2007, Bakal et al., 2007, Hempel et al., 2006, Ren et al., 2007, Somma et al., 2008, Corrigall et al., 2007, Schuldiner et al., 2008, Cao et al., 2008, Ng, 2008, Pham et al., 2008, Fulga et al., 2007, Williams et al., 2006, Castellanos et al., 2008, Sese et al., 2006, von Blume et al., 2009, Shuai et al., 2010, Johnson et al., 2008, Chen et al., 2005, Wang et al., 2010, Zhang et al., 2011) Tsr (Rebelo and Janody, 2007, Johnson et al., 2008)
Name Synonym	actin-depolymerizing factor (Pham et al., 2008) ADFcofilin (Silver and Montell, 2001) cofilin (Fernandez, 2004, Guild and Tilney, 2001, Miller, 2002, Niwa et al., 2002, Anonymous, 2001, Anonymous, 2001, Iwasa and Mullins, 2007, Sordella and Van, 2006, Lecuit, 2004, D'Avino et al., 2005, Silverman-Gavrila et al., 2008, Corrigall et al., 2007, Johnson et al., 2008, Medina et al., 2008, Pham et al., 2008, Fulga et al., 2007, Williams et al., 2006, Jovceva et al., 2007, Zhang et al., 2011, D'Ambrosio and Vale, 2010) Cofilin (Jacinto and Baum, 2003, Schober and Perrimon, 2002, Baum, 2002, Janody and Treisman, 2006, Ang et al., 2006, Rogers et al., 2003, Pimentel et al., 2007, Menzel et al., 2007, Marques, 2005, Serio et al., 2010) Cofilin/actin depolymerizing factor-like   DCofilin (Pichaud et al., 2007) no terminal filament (Chen et al., 1998, ) twinstar (Giansanti et al., 1995, Gunsalus et al., 1994, Chanut-Delalande et al., 2006, Dilks and DiNardo, 2007, Rogers et al., 2003, Iwasa and Mullins, 2007, Menzel et al., 2007, Somma et al., 2008, Cao et al., 2008, Medina et al., 2008, Williams et al., 2006, Castellanos et al., 2008, von Blume et al., 2009, Schuldiner et al., 2008, Shuai et al., 2010, Johnson et al., 2008, Sánchez-Soriano et al., 2010, Chen et al., 2005, Zhang et al., 2011, Cammarato et al., 2011) Twinstar (Rebelo and Janody, 2007, Blair et al., 2006, Bakal et al., 2007, Johnson et al., 2008, Fulga et al., 2007, Jovceva et al., 2007, Nie et al., 2009) twin star (Corrigall et al., 2007)
Secondary FlyBase IDs
	FBgn0011567 FBgn0020533 FBgn0020539 FBgn0022163 FBgn0024209
References ( 148 )
Generate a list of	All references relating to this gene ( 148 )
List References by type	Research paper  ( 70 ) Supplementary material  ( 11 ) Review  ( 23 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 22 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 10 )
	Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Zhang et al., 2011, Development 138(3): 455--464 Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. [FBrf0212692] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Monzo et al., 2010, Dev. Biol. 340(2): 408--418 Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. [FBrf0210519] Serio et al., 2010, Cell Host Microbe 7(5): 388--398 Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. [FBrf0210774] Shuai et al., 2010, Cell 140(4): 579--589 Forgetting Is Regulated through Rac Activity in Drosophila. [FBrf0210130] Sánchez-Soriano et al., 2010, Dev. Neurobiol. 70(1): 58--71 Drosophila growth cones: a genetically tractable platform for the analysis of axonal growth dynamics. [FBrf0209638] Wang et al., 2010, J. Cell Sci. 123(9): 1546--1556 Drosophila twinfilin is required for cell migration and synaptic endocytosis. [FBrf0210650] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...