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General Information
Symbol
Dmel\wts
Species
D. melanogaster
Name
warts
Annotation Symbol
CG12072
Feature Type
FlyBase ID
FBgn0011739
Gene Model Status
Stock Availability
Gene Snapshot
warts (wts) encodes a tumor suppressor kinase in the Hippo pathway involved in the control of tissue growth. It also plays a post-mitotic role in R8 photoreceptor cells where it antagonizes the product of melt to control the bistable choice of Rhodospin expression. [Date last reviewed: 2019-03-21]
Also Known As
lats, Warts/Lats, large tumor suppressor, LATS1, Lats/Warts
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:30,789,625..30,806,619 [-]
Recombination map
3-101
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (Q9VA38)
Summaries
Gene Group (FlyBase)
AGC KINASES (UNCLASSIFIED) -
The AGC kinase subfamily are serine/threonine kinases that were originally defined based on the sequence similarity of the catalytic domain. The AGC KINASE (UNCLASSIFIED) gene group represents AGC kinases that do not fall into the PKA, PKC or PKG families. (Adapted from FBrf0132098 and PMID:20027184).
Pathway (FlyBase)
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
Protein Function (UniProtKB)
Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism.
(UniProt, Q9VA38)
Summary (Interactive Fly)
a tumor suppressor kinase - regulates cell cycle - loss of gene function leads to the cell-autonomous formation of epithelial tumors in the adult integumentary structures derived from imaginal discs - plays a post-mitotic role in R8 photoreceptor cells where it antagonizes melt to control the bistable choice of Rhodospin expression
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\wts or the JBrowse view of Dmel\wts for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0085720
5803
1105
Additional Transcript Data and Comments
Reported size (kB)
~6 (northern blot)
5.7, 4.7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085082
122.5
1105
9.85
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with yki. Interacts with jub.
(UniProt, Q9VA38)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wts using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (33 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:Q9VY77
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q95RA8
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(assigned by GO_Central )
inferred from sequence or structural similarity
Biological Process (26 terms)
Terms Based on Experimental Evidence (19 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:sav; FB:FBgn0053193, FLYBASE:hpo; FB:FBgn0261456
inferred from mutant phenotype
inferred from direct assay
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
inferred from genetic interaction with FLYBASE:ft; FB:FBgn0001075
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-4 hr AEL

Additional Descriptive Data
wts transcripts are expressed throughout embryonic, larval, and pupal stages.
The 5.7kb wts transcript is detected throughout development.
The 4.7kb wts transcript is detected only in 0-4hr embryos and in adult males and females.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}wtsGAL4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}wtsP509-19
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wts in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
dorsal multidendritic neuron ddaC | somatic clone & dendritic tree
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
 
 
9 of 15
No
Yes
 
 
2 of 15
No
No
 
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
8 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
Rattus norvegicus (Norway rat) (3)
7 of 13
Yes
Yes
2 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
2 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (5)
9 of 15
Yes
Yes
8 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
9 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (13)
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
3 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902SH )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501AT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W013N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X011X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G028J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (15)
4 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
suppressible
External Data
Subunit Structure (UniProtKB)
Interacts with yki. Interacts with jub.
(UniProt, Q9VA38 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-101
Cytogenetic map
Sequence location
3R:30,789,625..30,806,619 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
100A5-100A5
Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
100A2-100A5
100A1-100A5
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (20)
Genomic Clones (16)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: wts miracle-gro
    Source for database merge of
    Additional comments
    One of the introns of wts has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the wts intron is mir-1013.
    Other Comments
    wts restricts intestine stem cell proliferation by limiting the activity of yki and sd in precursor cells.
    wts seems to have a crucial role in dendrite-specific morphogenesis.
    In wts mutants, dendrites initially tile the body wall normally, but progressively lose branches at later larval stages, whereas the axon shows no obvious defects.
    wts acts cell autonomously in class IV neurons.
    wts regulates expression of the ban miRNA.
    dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway.
    wts is a potential negative regulator of Jak/STAT signaling
    Involved in restricting tracheal terminal cell growth and branching.
    yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway.
    Genetic analysis of double mutants shows that wts acts downstream of melt.
    wts is required to induce the photoreceptor cell R8 of yellow ommatidium fate and to repress the photoreceptor cell R8 of pale ommatidium fate.
    When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells seen.
    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
    Molecular and genetic characterisation of wts reveals that wts encodes a predicted novel protein kinase. Mitotic recombination analysis demonstrates wts is required for the control of the amount and direction of cell proliferation as well as for normal cell morphogenesis. Loss of wts leads to a cell-autonomous formation of epithelial tumours in the adult integumentary structures derived from imaginal discs. wts is a tumour suppressor gene.
    Mitotic recombination clones homozygous for deficiencies of wts show overgrowth and abnormal morphogenesis indicating that wts is a tumor suppressor gene.
    Mutants display hyperplastic phenotype, showing tissue overgrowth in mitotic recombination clones.
    Two alleles were examined for zfh1 protein, and the mutations had no effect on zfh1 protein expression. Identification: Screen for zfh1 alleles.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 64 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    MENE (3R)-G
    Warts/Lats
    Wts
    (Alégot et al., 2019, Gokhale and Pfleger, 2019, Matsui and Lai, 2019, Meltzer et al., 2019, Nan et al., 2019, Bae and Luo, 2018, Carmena, 2018, Elbediwy and Thompson, 2018, Enomoto et al., 2018, Fulford et al., 2018, Gou et al., 2018, Kim and Jho, 2018, Simón-Carrasco et al., 2018, Hu et al., 2017, Jang et al., 2017, Ma et al., 2017, Richardson and Portela, 2017, Tue et al., 2017, Yamamoto et al., 2017, Fagegaltier et al., 2016, Fallahi et al., 2016, Jiang et al., 2016, Meng et al., 2016, Saadin and Starz-Gaiano, 2016, Viets et al., 2016, Bae et al., 2015, Cao et al., 2015, Gailite et al., 2015, Irvine and Harvey, 2015, Li et al., 2015, Cao et al., 2014, Hu et al., 2014, Qing et al., 2014, Sadeqzadeh et al., 2014, Andersen et al., 2013, Degoutin et al., 2013, Enderle and McNeill, 2013, Johnston, 2013, Matsui and Lai, 2013, Pan et al., 2013, Puram and Bonni, 2013, Ren et al., 2013, Rister et al., 2013, Thanawala et al., 2013, Vaque et al., 2013, Yin et al., 2013, Yu and Guan, 2013, Yu et al., 2013, Chen et al., 2012, Fausti et al., 2012, Liu et al., 2012, Chan et al., 2011, Genevet and Tapon, 2011, Gilbert et al., 2011, Halder and Johnson, 2011, Laprise, 2011, Losick et al., 2011, Salah and Aqeilan, 2011, Zhao et al., 2011, Cully et al., 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ling et al., 2010, Ren et al., 2010, Thomson and Johnson, 2010, Yu et al., 2010, Yu et al., 2010, Feng and Irvine, 2009, Koike-Kumagai et al., 2009, Oh and Irvine, 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Wu et al., 2008, Zhai et al., 2008, Dong et al., 2007, Feng and Irvine, 2007, Martin et al., 2007, Polesello and Tapon, 2007, Emoto et al., 2006, Hariharan, 2006, Polesello et al., 2006)
    l(3)100Aa
    wts
    (Gao et al., 2019, Khadilkar and Tanentzapf, 2019, Kim et al., 2019, Ly et al., 2019, Matsui et al., 2019, Sun et al., 2019, Texada et al., 2019, Azuma et al., 2018, Bohère et al., 2018, Cho et al., 2018, Courgeon et al., 2018, de Vreede et al., 2018, Forest et al., 2018, Gou et al., 2018, Jia et al., 2018, Katsukawa et al., 2018, Li et al., 2018, Oliveira et al., 2018, Saturnino et al., 2018, Tan et al., 2018, Tsai et al., 2018, Tsuboi et al., 2018, Wang et al., 2018, Xu et al., 2018, Yu and Pan, 2018, Baker, 2017, de Morais et al., 2017, Houtz et al., 2017, Moeller et al., 2017, Pascual et al., 2017, Su et al., 2017, Wells et al., 2017, Atkins et al., 2016, Deng et al., 2016, Huang et al., 2016, Jahanshahi et al., 2016, Jukam et al., 2016, Kuleesha et al., 2016, Liu et al., 2016, Losick et al., 2016, Mao et al., 2016, Park et al., 2016, Poon et al., 2016, Sakuma et al., 2016, Shih et al., 2016, Di Cara et al., 2015, Doggett et al., 2015, Enomoto et al., 2015, Fletcher et al., 2015, Gaspar et al., 2015, Kanoh et al., 2015, Keder et al., 2015, Kwon et al., 2015, Li et al., 2015, Parker and Struhl, 2015, Sidorov et al., 2015, Ugrankar et al., 2015, Wang and Baker, 2015, Wittkorn et al., 2015, Zaessinger et al., 2015, Zheng et al., 2015, Ashwal-Fluss et al., 2014, Bosch et al., 2014, Chen et al., 2014, Huang and Kalderon, 2014, Ikmi et al., 2014, Li et al., 2014, Lin et al., 2014, Oh et al., 2014, Rauskolb et al., 2014, Robbins et al., 2014, Sopko et al., 2014, Tipping and Perrimon, 2014, Campbell and Ganetzky, 2013, Huang et al., 2013, Ilanges et al., 2013, Jukam et al., 2013, Jukam et al., 2013, Koontz et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lucas et al., 2013, Ly et al., 2013, Mao et al., 2013, Marcinkevicius and Zallen, 2013, Oh et al., 2013, Pan et al., 2013, Vaqué et al., 2013, Webber et al., 2013, Wehr et al., 2013, Yin et al., 2013, Yin et al., 2013, Yu et al., 2013, Chen and Verheyen, 2012, Hafezi et al., 2012, Hazelett et al., 2012, Justiniano et al., 2012, Marinari et al., 2012, Matakatsu and Blair, 2012, Nagaraj et al., 2012, Nawaz et al., 2012, Poon et al., 2012, Verghese et al., 2012, Ye et al., 2012, Bao et al., 2011, Boggiano et al., 2011, Chen et al., 2011, Fernández et al., 2011, Grusche et al., 2011, Kawamori et al., 2011, Kirsanov et al., 2011, Napoletano et al., 2011, Poon et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Salah and Aqeilan, 2011, Vasiliauskas et al., 2011, Wen et al., 2011, Zhang et al., 2011, Zhang et al., 2011, Baumgartner et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Dolezal et al., 2010, Fang and Adler, 2010, Ho et al., 2010, Milton et al., 2010, Nedelsky et al., 2010, Neto-Silva et al., 2010, Nicolay et al., 2010, Reddy et al., 2010, Ren et al., 2010, Ribeiro et al., 2010, Shaw et al., 2010, Varelas et al., 2010, Wendler et al., 2010, Zecca and Struhl, 2010, Zeng et al., 2010, Ziosi et al., 2010, Badouel et al., 2009, Peng et al., 2009, Zhang et al., 2009, Baena-Lopez et al., 2008, Dutta and Baehrecke, 2008, Nicolay and Frolov, 2008, Oh and Irvine, 2008, Shimizu et al., 2008, Simcox et al., 2008, Simcox et al., 2008, Sun et al., 2008, Yu et al., 2008, Zhang et al., 2008, Zhao et al., 2008, Fang and Adler, 2007, Meignin et al., 2007, Parrish et al., 2007, Pistillo and Desplan, 2007, Polesello and Tapon, 2007, Sprecher et al., 2007, Tountas and Fortini, 2007, Tyler et al., 2007, Wei et al., 2007, Bennett and Harvey, 2006, Cho et al., 2006, Colombani et al., 2006, Dorus et al., 2006, Hamaratoglu et al., 2006, Hamaratoglu et al., 2006, Nolo et al., 2006, Polesello et al., 2006, Willecke et al., 2006, He et al., 2005, Mikeladze-Dvali et al., 2005, Stanyon et al., 2004, Pantalacci, 2003, Sidorov et al., 2003, Sidorov et al., 2001)
    wts/lats
    Name Synonyms
    LARGE tumor suppressor
    Large Tumor Suppressor
    Warts kinase
    large tumor supressor
    warts/large tumour suppressor
    Secondary FlyBase IDs
    • FBgn0013549
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (521)