General Information
Symbol
Dmel\wts
Species
D. melanogaster
Name
warts
Annotation Symbol
CG12072
Feature Type
FlyBase ID
FBgn0011739
Gene Model Status
Stock Availability
Gene Snapshot
Warts is a tumor suppressor kinase in the Hippo pathway involved in the control of tissue growth. It also plays a post-mitotic role in R8 photoreceptor cells where it antagonizes melt to control the bistable choice of Rhodospin expression. [Date last reviewed: 2016-06-23]
Also Known As
lats, Warts, LATS1, Lats/Warts, warts/lats
Genomic Location
Cytogenetic map
Sequence location
3R:30,789,625..30,806,619 [-]
Recombination map
3-101
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (Q9VA38)
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
AGC KINASES (UNCLASSIFIED) -
The AGC kinase subfamily are serine/threonine kinases that were originally defined based on the sequence similarity of the catalytic domain. The AGC KINASE (UNCLASSIFIED) gene group represents AGC kinases that do not fall into the PKA, PKC or PKG families. (Adapted from FBrf0132098 and PMID:20027184).
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
UniProt Contributed Function Data
Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism.
(UniProt, Q9VA38)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\wts or the JBrowse view of Dmel\wts for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0085720
5803
1105
Additional Transcript Data and Comments
Reported size (kB)
~6 (northern blot)
5.7, 4.7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085082
122.5
1105
9.85
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with yki. Interacts with jub.
(UniProt, Q9VA38)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wts using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (32 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:Q9VY77
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q95RA8
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(assigned by GO_Central )
inferred from sequence or structural similarity
non-traceable author statement
Biological Process (25 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:sav; FB:FBgn0053193, FLYBASE:hpo; FB:FBgn0261456
inferred from mutant phenotype
inferred from direct assay
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
inferred from genetic interaction with FLYBASE:ft; FB:FBgn0001075
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002390470
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 0-4 hr AEL

Additional Descriptive Data
wts transcripts are expressed throughout embryonic, larval, and pupal stages.
The 5.7kb wts transcript is detected throughout development.
The 4.7kb wts transcript is detected only in 0-4hr embryos and in adult males and females.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}wtsGAL4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}wtsP509-19
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wts in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 98 )
For All Classical and Insertion Alleles Show
 
Allele of wts
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
      Other relevant insertions
      Transgenic Constructs ( 25 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of wts
      Allele of wts
      Mutagen
      Associated Transgenic Construct
      Stocks
      Transgenic constructs containing regulatory region of wts
      characterization construct
      Name
      Expression Data
      Deletions and Duplications ( 21 )
      Summary of Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      Sterility
      Allele
      Other Phenotypes
      Allele
      Phenotype manifest in
      Allele
      dorsal multidendritic neuron ddaC | somatic clone & dendritic tree
      Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (4)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      10 of 15
      Yes
      Yes
       
       
      9 of 15
      No
      Yes
       
       
      2 of 15
      No
      No
       
      2 of 15
      No
      No
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (4)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      10 of 15
      Yes
      Yes
      8 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      Rattus norvegicus (Norway rat) (3)
      7 of 13
      Yes
      Yes
      2 of 13
      No
      Yes
      1 of 13
      No
      No
      Xenopus tropicalis (Western clawed frog) (3)
      2 of 12
      Yes
      Yes
      1 of 12
      No
      No
      1 of 12
      No
      No
      Danio rerio (Zebrafish) (5)
      9 of 15
      Yes
      Yes
      8 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      No
      Caenorhabditis elegans (Nematode, roundworm) (3)
      9 of 15
      Yes
      Yes
      1 of 15
      No
      No
      1 of 15
      No
      No
      Arabidopsis thaliana (thale-cress) (13)
      2 of 9
      Yes
      No
      2 of 9
      Yes
      No
      2 of 9
      Yes
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      No
      1 of 9
      No
      Yes
      1 of 9
      No
      No
      Saccharomyces cerevisiae (Brewer's yeast) (4)
      3 of 15
      Yes
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      Schizosaccharomyces pombe (Fission yeast) (1)
      1 of 12
      Yes
      No
      Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902SH )
      Organism
      Common Name
      Gene
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila melanogaster
      fruit fly
      Drosophila suzukii
      Spotted wing Drosophila
      Drosophila simulans
      Drosophila sechellia
      Drosophila erecta
      Drosophila yakuba
      Drosophila ananassae
      Drosophila pseudoobscura pseudoobscura
      Drosophila persimilis
      Drosophila willistoni
      Drosophila virilis
      Drosophila mojavensis
      Drosophila grimshawi
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501AT )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Musca domestica
      House fly
      Glossina morsitans
      Tsetse fly
      Lucilia cuprina
      Australian sheep blowfly
      Mayetiola destructor
      Hessian fly
      Mayetiola destructor
      Hessian fly
      Aedes aegypti
      Yellow fever mosquito
      Anopheles darlingi
      American malaria mosquito
      Anopheles darlingi
      American malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W013N )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Bombyx mori
      Silkmoth
      Danaus plexippus
      Monarch butterfly
      Heliconius melpomene
      Postman butterfly
      Apis florea
      Little honeybee
      Apis mellifera
      Western honey bee
      Bombus impatiens
      Common eastern bumble bee
      Bombus terrestris
      Buff-tailed bumblebee
      Linepithema humile
      Argentine ant
      Megachile rotundata
      Alfalfa leafcutting bee
      Nasonia vitripennis
      Parasitic wasp
      Dendroctonus ponderosae
      Mountain pine beetle
      Tribolium castaneum
      Red flour beetle
      Pediculus humanus
      Human body louse
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Cimex lectularius
      Bed bug
      Acyrthosiphon pisum
      Pea aphid
      Acyrthosiphon pisum
      Pea aphid
      Zootermopsis nevadensis
      Nevada dampwood termite
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X011X )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strigamia maritima
      European centipede
      Strigamia maritima
      European centipede
      Ixodes scapularis
      Black-legged tick
      Stegodyphus mimosarum
      African social velvet spider
      Tetranychus urticae
      Two-spotted spider mite
      Daphnia pulex
      Water flea
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G028J )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Ciona intestinalis
      Vase tunicate
      Ciona intestinalis
      Vase tunicate
      Gallus gallus
      Domestic chicken
      Gallus gallus
      Domestic chicken
      Gallus gallus
      Domestic chicken
      Gallus gallus
      Domestic chicken
      Human Disease Model Data
      FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 3 )
      Allele
      Disease
      Evidence
      References
      model of  benign neoplasm
      inferred from mutant phenotype
      inferred from mutant phenotype
      model of  cancer
      in combination with pnutGD1512
      Interactions ( 1 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser

      Please look at the Interaction Group reports for full details of the physical interactions
      protein-protein
      Interacting group
      Assay
      References
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      suppressible
      External Data
      Subunit Structure (UniProtKB)
      Interacts with yki. Interacts with jub.
      (UniProt, Q9VA38 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      Hippo Signaling Pathway Core Components -
      The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-101
      Cytogenetic map
      Sequence location
      3R:30,789,625..30,806,619 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      100A5-100A5
      Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      100A2-100A5
      100A1-100A5
      Experimentally Determined Recombination Data
      Location
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (18)
      Genomic Clones (16)
       
      cDNA Clones (22)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: wts miracle-gro
        Source for database merge of
        Additional comments
        One of the introns of wts has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the wts intron is mir-1013.
        Other Comments
        wts restricts intestine stem cell proliferation by limiting the activity of yki and sd in precursor cells.
        wts seems to have a crucial role in dendrite-specific morphogenesis.
        In wts mutants, dendrites initially tile the body wall normally, but progressively lose branches at later larval stages, whereas the axon shows no obvious defects.
        wts acts cell autonomously in class IV neurons.
        wts regulates expression of the ban miRNA.
        dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway.
        wts is a potential negative regulator of Jak/STAT signaling
        Involved in restricting tracheal terminal cell growth and branching.
        yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway.
        Genetic analysis of double mutants shows that wts acts downstream of melt.
        wts is required to induce the photoreceptor cell R8 of yellow ommatidium fate and to repress the photoreceptor cell R8 of pale ommatidium fate.
        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells seen.
        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
        RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
        Molecular and genetic characterisation of wts reveals that wts encodes a predicted novel protein kinase. Mitotic recombination analysis demonstrates wts is required for the control of the amount and direction of cell proliferation as well as for normal cell morphogenesis. Loss of wts leads to a cell-autonomous formation of epithelial tumours in the adult integumentary structures derived from imaginal discs. wts is a tumour suppressor gene.
        Mitotic recombination clones homozygous for deficiencies of wts show overgrowth and abnormal morphogenesis indicating that wts is a tumor suppressor gene.
        Mutants display hyperplastic phenotype, showing tissue overgrowth in mitotic recombination clones.
        Two alleles were examined for zfh1 protein, and the mutations had no effect on zfh1 protein expression. Identification: Screen for zfh1 alleles.
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 54 )
        Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Synonyms and Secondary IDs (30)
        Reported As
        Symbol Synonym
        MENE (3R)-G
        Warts/Lats
        Wts
        (Bae and Luo, 2018, Carmena, 2018, Elbediwy and Thompson, 2018, Enomoto et al., 2018, Fulford et al., 2018, Gou et al., 2018, Kim and Jho, 2018, Simón-Carrasco et al., 2018, Hu et al., 2017, Jang et al., 2017, Ma et al., 2017, Richardson and Portela, 2017, Tue et al., 2017, Yamamoto et al., 2017, Fagegaltier et al., 2016, Fallahi et al., 2016, Jiang et al., 2016, Meng et al., 2016, Saadin and Starz-Gaiano, 2016, Viets et al., 2016, Bae et al., 2015, Cao et al., 2015, Gailite et al., 2015, Irvine and Harvey, 2015, Li et al., 2015, Cao et al., 2014, Hu et al., 2014, Qing et al., 2014, Sadeqzadeh et al., 2014, Andersen et al., 2013, Degoutin et al., 2013, Enderle and McNeill, 2013, Johnston, 2013, Matsui and Lai, 2013, Pan et al., 2013, Puram and Bonni, 2013, Ren et al., 2013, Rister et al., 2013, Thanawala et al., 2013, Vaque et al., 2013, Yin et al., 2013, Yu and Guan, 2013, Yu et al., 2013, Chen et al., 2012, Fausti et al., 2012, Liu et al., 2012, Chan et al., 2011, Genevet and Tapon, 2011, Gilbert et al., 2011, Halder and Johnson, 2011, Laprise, 2011, Salah and Aqeilan, 2011, Cully et al., 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ling et al., 2010, Ren et al., 2010, Thomson and Johnson, 2010, Yu et al., 2010, Yu et al., 2010, Feng and Irvine, 2009, Koike-Kumagai et al., 2009, Oh and Irvine, 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Wu et al., 2008, Zhai et al., 2008, Dong et al., 2007, Feng and Irvine, 2007, Martin et al., 2007, Polesello and Tapon, 2007, Emoto et al., 2006, Hariharan, 2006, Polesello et al., 2006)
        l(3)100Aa
        wts
        (Azuma et al., 2018, de Vreede et al., 2018, Gou et al., 2018, Li et al., 2018, Oliveira et al., 2018, Saturnino et al., 2018, Tan et al., 2018, Tsai et al., 2018, Tsuboi et al., 2018, Xu et al., 2018, Yu and Pan, 2018, Baker, 2017, de Morais et al., 2017, Houtz et al., 2017, Moeller et al., 2017, Pascual et al., 2017, Su et al., 2017, Wells et al., 2017, Atkins et al., 2016, Deng et al., 2016, Huang et al., 2016, Jahanshahi et al., 2016, Jukam et al., 2016, Liu et al., 2016, Losick et al., 2016, Mao et al., 2016, Park et al., 2016, Poon et al., 2016, Sakuma et al., 2016, Shih et al., 2016, Di Cara et al., 2015, Enomoto et al., 2015, Fletcher et al., 2015, Gaspar et al., 2015, Kanoh et al., 2015, Keder et al., 2015, Kwon et al., 2015, Li et al., 2015, Parker and Struhl, 2015, Sidorov et al., 2015, Ugrankar et al., 2015, Wang and Baker, 2015, Wittkorn et al., 2015, Zaessinger et al., 2015, Zheng et al., 2015, Ashwal-Fluss et al., 2014, Bosch et al., 2014, Chen et al., 2014, Huang and Kalderon, 2014, Ikmi et al., 2014, Li et al., 2014, Lin et al., 2014, Oh et al., 2014, Rauskolb et al., 2014, Robbins et al., 2014, Sopko et al., 2014, Tipping and Perrimon, 2014, Campbell and Ganetzky, 2013, Huang et al., 2013, Ilanges et al., 2013, Jukam et al., 2013, Jukam et al., 2013, Koontz et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lucas et al., 2013, Ly et al., 2013, Mao et al., 2013, Marcinkevicius and Zallen, 2013, Oh et al., 2013, Pan et al., 2013, Vaqué et al., 2013, Webber et al., 2013, Wehr et al., 2013, Yin et al., 2013, Yin et al., 2013, Yu et al., 2013, Chen and Verheyen, 2012, Hafezi et al., 2012, Hazelett et al., 2012, Justiniano et al., 2012, Marinari et al., 2012, Matakatsu and Blair, 2012, Nagaraj et al., 2012, Nawaz et al., 2012, Poon et al., 2012, Verghese et al., 2012, Ye et al., 2012, Bao et al., 2011, Boggiano et al., 2011, Chen et al., 2011, Fernández et al., 2011, Grusche et al., 2011, Kawamori et al., 2011, Kirsanov et al., 2011, Napoletano et al., 2011, Poon et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Salah and Aqeilan, 2011, Vasiliauskas et al., 2011, Wen et al., 2011, Zhang et al., 2011, Zhang et al., 2011, Baumgartner et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Dolezal et al., 2010, Fang and Adler, 2010, Ho et al., 2010, Milton et al., 2010, Nedelsky et al., 2010, Neto-Silva et al., 2010, Nicolay et al., 2010, Reddy et al., 2010, Ren et al., 2010, Ribeiro et al., 2010, Shaw et al., 2010, Varelas et al., 2010, Wendler et al., 2010, Zecca and Struhl, 2010, Zeng et al., 2010, Ziosi et al., 2010, Badouel et al., 2009, Peng et al., 2009, Zhang et al., 2009, Baena-Lopez et al., 2008, Dutta and Baehrecke, 2008, Nicolay and Frolov, 2008, Oh and Irvine, 2008, Shimizu et al., 2008, Simcox et al., 2008, Simcox et al., 2008, Sun et al., 2008, Yu et al., 2008, Zhang et al., 2008, Zhao et al., 2008, Fang and Adler, 2007, Meignin et al., 2007, Parrish et al., 2007, Pistillo and Desplan, 2007, Polesello and Tapon, 2007, Sprecher et al., 2007, Tountas and Fortini, 2007, Tyler et al., 2007, Wei et al., 2007, Bennett and Harvey, 2006, Cho et al., 2006, Colombani et al., 2006, Dorus et al., 2006, Hamaratoglu et al., 2006, Hamaratoglu et al., 2006, Nolo et al., 2006, Polesello et al., 2006, Willecke et al., 2006, He et al., 2005, Mikeladze-Dvali et al., 2005, Stanyon et al., 2004, Pantalacci, 2003, Sidorov et al., 2003, Sidorov et al., 2001)
        wts/lats
        Name Synonyms
        LARGE tumor suppressor
        Large Tumor Suppressor
        Warts kinase
        large tumor supressor
        warts/large tumour suppressor
        Secondary FlyBase IDs
        • FBgn0013549
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
        References (490)