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Gene Dmel\α-Man-II

General Information
Symbol	Dmel\α-Man-II	Species	D. melanogaster
Name	α Mannosidase II	Annotation symbol	CG18802
Feature type	protein_coding_gene	FlyBase ID	FBgn0011740
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dGMII, GMII, alpha-Man-II
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85D15-85D16	Sequence location	3R:5,238,271..5,242,986 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α Mannosidase II is referred to in FlyBase by the symbol Dmel\α-Man-II (CG18802, FBgn0011740). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: mannosidase activity. There is experimental evidence that it is involved in the biological process: protein deglycosylation. 11 alleles are reported. The phenotype of these alleles is annotated with: eye. It has one annotated transcript and one annotated polypeptide. Protein features are: Glycoside hydrolase, family 38, central domain; Glycoside hydrolase, family 38, core; Glycoside hydrolase-type carbohydrate-binding; Glycoside hydrolase/deacetylase, beta/alpha-barrel; Glycosyl hydrolase, family 13, all-beta; Glycosyl hydrolases 38, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626112_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alpha-Man-II. Gene sequence location is 3R:5238271..5242986.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Cao et al., 2011, EMBO J. 30(18): 3701--3713 Alleles alpha-Man-II[S73G.Scer\UAS.T:Hsap\MYC] alpha-Man-II[LL01094] alpha-Man-II[Scer\UAS.T:Hsap\MYC] Controlled Vocabulary Terms mannosidase activity protein deglycosylation Insertions PBac{SAstopDsRed}alpha-Man-II[LL01094] Sequence features BKN45364 HFA15393 BKN20772
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85D15-85D16   Limits computationally determined from genome sequence between P{lacW}l(3)L4092L4092 and P{PZ}ps10615&P{PZ}Ras85D06677
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85D11-85D17     (Foster, 1994.2.8) 85D14-85D18   (determined by in situ hybridisation)   (Tchoubrieva and Roberts, 1997) 85D14-85D18   (determined by in situ hybridisation)   (Foster et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\α-Man-II for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) alpha-Man-II-RA FBtr0082031  NM_079567   3998   1108
Additional Transcript Data & Comments
Reported size (kB)	3.926 (longest cDNA) (Foster et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein alpha-Man-II-PA   FBpp0081509   126.7   1108   7.20     NP_524291   AAF54375
Additional Polypeptide Data & Comments
Reported size (kDa)	1108 (aa); 127 (kD predicted) (Foster et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 38, core (IPR000602) Glycoside hydrolase-type carbohydrate-binding (IPR011013) Glycosyl hydrolases 38, C-terminal (IPR011682) Glycoside hydrolase/deacetylase, beta/alpha-barrel (IPR011330) Glycosyl hydrolase, family 13, all-beta (IPR013780) Glycoside hydrolase, family 38, central domain (IPR015341) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1HTY 1HWW 1HXK
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA942006   AE014297 AAF54375   AI114424   AI238796   AI401932   AI405040   AI456535   AJ132715 CAA10755   AY119464 AAM50118   BG640338   BI238220   BI368872   BI612110   BI638284   CK659705   CO189973   CO267428   CO326508   CO339138   CO341968   CQ869497 CAH33908   CQ869513   CQ869514   CQ869515   CQ869516   CZ475121   EC070881   EC080806   EC210522   EC218068   EC231368   EC246058   EC252221   EC254406   EC258886   X77652 CAA54732
UniProtKB/Swiss-Prot	Q24451
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011740    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011740 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011740 expression level Developmental Stage   Expression Level embryo 00-02hr    2880 embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr    1796 embryo 08-10hr    1654 embryo 10-12hr    1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr    2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day    1589 adult female 30day    1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2880) embryo 02-04hr  (589) embryo 04-06hr  (784) embryo 06-08hr  (1796) embryo 08-10hr  (1654) embryo 10-12hr  (1452) embryo 12-14hr  (1198) embryo 14-16hr  (940) embryo 16-18hr  (594) embryo 18-20hr  (365) embryo 20-22hr  (214) embryo 22-24hr  (266) larva L1  (525) larva L2  (488) larva L3 12hr old  (408) larva L3 puffstage 1-2  (565) larva L3 puffstage 3-6  (935) larva L3 puffstage 7-9  (1190) white prepupae new  (1271) white prepupae 12hr  (1343) white prepupae 24hr  (2159) pupae 2d postWPP  (1135) pupae 3d postWPP  (535) pupae 4d postWPP  (424) adult male 01day  (801) adult male 05day  (1059) adult male 30day  (1085) adult female 01day  (1013) adult female 05day  (1589) adult female 30day  (1698) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2880) embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr  (1796) embryo 08-10hr  (1654) embryo 10-12hr  1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr  (2159) pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day  (1589) adult female 30day  (1698) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2880 embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr    1796 embryo 08-10hr    1654 embryo 10-12hr    1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr    2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day    1589 adult female 30day    1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2880 embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr    1796 embryo 08-10hr    1654 embryo 10-12hr    1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr    2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day    1589 adult female 30day    1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011740 expression level Developmental Stage   Expression Level embryo 00-02hr    2880 embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr    1796 embryo 08-10hr    1654 embryo 10-12hr    1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr    2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day    1589 adult female 30day    1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2880) embryo 02-04hr  (589) embryo 04-06hr  (784) embryo 06-08hr  (1796) embryo 08-10hr  (1654) embryo 10-12hr  (1452) embryo 12-14hr  (1198) embryo 14-16hr  (940) embryo 16-18hr  (594) embryo 18-20hr  (365) embryo 20-22hr  (214) embryo 22-24hr  (266) larva L1  (525) larva L2  (488) larva L3 12hr old  (408) larva L3 puffstage 1-2  (565) larva L3 puffstage 3-6  (935) larva L3 puffstage 7-9  (1190) white prepupae new  (1271) white prepupae 12hr  (1343) white prepupae 24hr  (2159) pupae 2d postWPP  (1135) pupae 3d postWPP  (535) pupae 4d postWPP  (424) adult male 01day  (801) adult male 05day  (1059) adult male 30day  (1085) adult female 01day  (1013) adult female 05day  (1589) adult female 30day  (1698) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2880) embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr  1796 embryo 08-10hr  1654 embryo 10-12hr  1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr  2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day  1589 adult female 30day  1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2880 embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr    1796 embryo 08-10hr    1654 embryo 10-12hr    1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr    2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day    1589 adult female 30day    1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2880 embryo 02-04hr    589 embryo 04-06hr    784 embryo 06-08hr    1796 embryo 08-10hr    1654 embryo 10-12hr    1452 embryo 12-14hr    1198 embryo 14-16hr    940 embryo 16-18hr    594 embryo 18-20hr    365 embryo 20-22hr    214 embryo 22-24hr    266 larva L1    525 larva L2    488 larva L3 12hr old    408 larva L3 puffstage 1-2    565 larva L3 puffstage 3-6    935 larva L3 puffstage 7-9    1190 white prepupae new    1271 white prepupae 12hr    1343 white prepupae 24hr    2159 pupae 2d postWPP    1135 pupae 3d postWPP    535 pupae 4d postWPP    424 adult male 01day    801 adult male 05day    1059 adult male 30day    1085 adult female 01day    1013 adult female 05day    1589 adult female 30day    1698 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011740    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011740 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011740 expression level Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland    628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland  (628.6) Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland    628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland    628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011740 expression level Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland    628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland  628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland    628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    266.2 Larval Midgut no informative data Larval Hindgut    77.9 Larval Malpighian Tubules    90.3 Larval Fat Body    60.1 Larval Salivary Gland    107.1 Larval Trachea    148.65 Larval Carcass    134.225 Adult Head    117.7 Adult Eye    146.45 Adult Brain    199.1 Adult Thoracic-Abdominal Ganglion    195.6 Adult Crop    79.6 Adult Midgut    23.2 Adult Hindgut    48.3 Adult Malpighian Tubules    204.4 Adult Fat Body    78.7 Adult Salivary Gland    79.2 Adult Heart    79.3 Adult VirginFemale Spermatheca    70.8 Adult InseminatedFemale Spermatheca    80.8 Adult Ovary    209.2 Adult Testis    100.7 Adult Male Accessory Gland    628.6 Adult Carcass    67.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    117.7   NA  Eye    146.45   NA  Brain    199.1   266.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    195.6   NA  Crop    79.6   no informative data  Midgut    23.2   77.9  Hindgut    48.3   90.3  Malpighian Tubules    204.4   60.1  Fat Body    78.7   107.1  Salivary Gland    79.2   NA  Heart    79.3   148.65  Trachea    NA   NA  VirginFemale Spermatheca    70.8   NA  InseminatedFemale Spermatheca    80.8   NA  Ovary    209.2   NA  Testis    100.7   NA  Male Accessory Gland    628.6   134.225  Carcass    67.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011740 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18802-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Tn10\tetR[-]: α-Man-IIPdL19B3 viable, with Scer\GAL4pnr-MD237 α-Man-IIGD2875 Other Phenotypes Allele long lived, with Tn10\tetRAct5C.T:Hsim\VP16 α-Man-IIPdL19B3 visible, with Tn10\tetRAct5C.T:Hsim\VP16 α-Man-IIPdL19B3 Phenotype manifest in Allele eye, with Tn10\tetRAct5C.T:Hsim\VP16 α-Man-IIPdL19B3
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of α-Man-II Class Mutagen Stocks Known lesion α-Man-IId06422 P-element activity 1 -- α-Man-IIG4901 P-element activity 1 -- α-Man-IILL01094 1 -- α-Man-IIPdL19B3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of α-Man-II Class Mutagen Stocks Known lesion α-Man-IIGD2875 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes α-Man-IIAct5C.T:Disc\RFP-DsRed2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes α-Man-IIcvdEa in vitro construct 0 Yes α-Man-IIS73G.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes α-Man-IIScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes α-Man-IIScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes α-Man-IIΔ.MtnA.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-α-Man-II.R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}α-Man-IIG4901 NA P{PdL}α-Man-IIPdL19B3 NA P{XP}α-Man-IId06422 NA miscellaneous insertions PBac{SAstopDsRed}α-Man-IILL01094 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
mannosidase activity inferred from direct assay (Cao et al., 2011)
Biological Process
CV term Evidence References
protein deglycosylation inferred from direct assay (Cao et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
alpha-mannosidase activity inferred from electronic annotation with InterPro:IPR000602 (FlyBase Curators et al., 2004-) carbohydrate binding inferred from electronic annotation with InterPro:IPR011013 (FlyBase Curators et al., 2004-) mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity inferred from sequence or structural similarity with UniProtKB:Q24451 (FlyBase, 1992-) non-traceable author statement (Foster, 1994.2.8, Swiss-Prot Project Members, 1998.2.1) zinc ion binding inferred from electronic annotation with InterPro:IPR015341 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mannose metabolic process inferred from electronic annotation with InterPro:IPR011682 (FlyBase Curators et al., 2004-) protein glycosylation inferred from sequence or structural similarity with UniProtKB:Q24451 (FlyBase, 1992-) protein N-linked glycosylation non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Cellular Component
CV term Evidence References
endoplasmic reticulum non-traceable author statement (Kondylis et al., 2001) Golgi membrane inferred from sequence or structural similarity with mouse Man2a1 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1998.2.1) Golgi stack non-traceable author statement (Kondylis et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions α-Man-II allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66291 DroID - A comprehensive database of gene and protein interactions. • FBgn0011740 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41126
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17213 Dere\GG16776 Dgri\GH18434 Dmoj\GI24010 Dper\GL13822 Dpse\GA15085 Dsec\GM23804 Dsim\GD18615 Dvir\GJ23640 Dwil\GK10956 Dyak\GE25950
Curated drosophilid orthologs	Dpse\GA15085   Dsim\α-Man-II
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011978-PA Aedes aegypti (mosquito) AGAP004020-PA Anopheles gambiae (mosquito) XP_624759.2 Apis mellifera (honey bee) XP_001946979.1 Acyrthosiphon pisum (pea aphid) At5g14950.1 Arabidopsis thaliana (wall cress) 216394 Branchiostoma floridae (lancelet) XP_001897356.1 Brugia malayi (roundworm nematode) BGIBMGA005142-PA Bombyx mori (silk worm) ENSBTAP00000025161 Bos taurus (bovine) CBP31464 Caenorhabditis briggsae (nematode) CE39509 Caenorhabditis elegans (worm) ENSCAFP00000011020 Canis familiaris (dog) ENSCINP00000023920 Ciona intestinalis (sea squirt) JA11181 Caenorhabditis japonica (nematode) CPIJ009720 Culex pipens (mosquito) ENSCPOP00000006698 Cavia porcellus (guinea pig) RP30760 Caenorhabditis remanei (nematode) ENSCSAVP00000008365 Ciona savignyi (sedentary tunicate) 167403 Capitella spl (polychaete worm) ENSDARP00000086327 Danio rerio (zebra fish) ENSECAP00000020639 Equus caballus (horse) ENSGACP00000015208 Gymnopilus aculeatus (mushroom) ENSGALP00000000333 Gallus gallus (chicken) 110840 Hypsipyla robusta (cedar shoot borer) ENSP00000261483 Homo sapiens (human) ISCW018027-PA Ixodes scapularis (deer tick) 188902 Lottia gigantea (owl limpet) ENSMODP00000024280 Monodelphis domestica (gray opossum) ENSMMUP00000004423 Macaca mulatta (rhesus monkey) ENSMUSP00000083928 Mus musculus (house mouse) 166900 Nematostella vectensis (starlet anemone) XP_001601023.1 Nasonia vitripennis (wasp) ENSOANP00000018059 Ornithorynchus anatinus (platypus) ENSORLP00000014907 Oryzias latipes (japanese killifish) LOC_Os06g13650.1 Oryza sativa (asian rice) PHUM003705-PA Pediculus humanus (human body louse) PP23662 Pristionchus pacificus (nematode) 159159 Physcomitrella patens (moss) ENSPPYP00000017527 Pongo pygmaeus (orangutan) 549487 Populus trichocarpa (black cottonwood) ENSPTRP00000048125 Pan troglodytes (chimpanzee) ENSRNOP00000020767 Rattus norvegicus (norway rat) 5061581 Sorghum bicolor (sorghum) Smp_143430 Schistosoma mansoni (trematode parasite) 60265 Trichoplax adhaerens (metazoa) XP_972030.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015129 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000001660 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033737 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14616 NV15211 LH20387 ISCW018027 FBgn0242997 FBgn0212967 FBgn0210737 FBgn0190137 FBgn0178669 FBgn0075110 FBgn0151427 FBgn0146733 FBgn0125902 FBgn0109006 FBgn0094231 CPIJ009720 BGIBMGA005142 ACYPI009717 GB19751 AGAP004020 AAEL011978 PHUM459490 GLEAN_09186
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	30106 w1118; P{EP}α-Man-IIG4901
Harvard	- P{XP}α-Man-IId06422
Kyoto	140255 y* w*; P{FRT(whs)}2A P{neoFRT}82B PBac{SAstopDsRed}α-Man-IILL01094 P{Car20y}96E/TM6B, Tb1
VDRC	v5838 w1118; P{GD2875}v5838
Genomic Clones ( 1 )
	BACR19J06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03876
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14911 GH24948 LD27388 LD36582 LP17650 RE34620 RE54926 RH40512 SD11332 SD20533
Other clones	EK045822 EK150114 EP00935 EP04032 EP13537
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011740 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41126
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: α-Man-II CG18474 (Whitfield, 2000.12.15) Source for merge of: α-Man-II CG18802 (FlyBase, 1996-)
Additional comments	Source for merge of α-Man-II CG18802 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
	α-Man-II is cloned and the amino acid sequence shows similarity to the murine Man II protein. (Foster et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079567 RefSeq (Proteins) • NP_524291 DDBJ / EMBL / GenBank • AAF54375 AAM50118 AI114424 AI401932 AJ132715 AY119464 CAA10755 CAA54732 CAH33908 CQ869497 CQ869513 CQ869514 CQ869515 CQ869516 CZ475121 X77652 Entrez Gene - A searchable database of RefSeq genes. • 41126 UniProtKB/Swiss-Prot • Q24451
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 38, core (IPR000602) Glycoside hydrolase-type carbohydrate-binding (IPR011013) Glycosyl hydrolases 38, C-terminal (IPR011682) Glycoside hydrolase/deacetylase, beta/alpha-barrel (IPR011330) Glycosyl hydrolase, family 13, all-beta (IPR013780) Glycoside hydrolase, family 38, central domain (IPR015341) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1HTY 1HWW 1HXK
Linkouts
	BioGRID - A database of protein and genetic interactions • 66291 DroID - A comprehensive database of gene and protein interactions. • FBgn0011740 DRSC - Results from RNAi screens. • FBgn0011740 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011740 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18802-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011740 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41126 InParanoid A subset of ortholog calls from InParanoid. • AAEL011978-PA Aedes aegypti (mosquito) AGAP004020-PA Anopheles gambiae (mosquito) XP_624759.2 Apis mellifera (honey bee) XP_001946979.1 Acyrthosiphon pisum (pea aphid) At5g14950.1 Arabidopsis thaliana (wall cress) 216394 Branchiostoma floridae (lancelet) XP_001897356.1 Brugia malayi (roundworm nematode) BGIBMGA005142-PA Bombyx mori (silk worm) ENSBTAP00000025161 Bos taurus (bovine) CBP31464 Caenorhabditis briggsae (nematode) CE39509 Caenorhabditis elegans (worm) ENSCAFP00000011020 Canis familiaris (dog) ENSCINP00000023920 Ciona intestinalis (sea squirt) JA11181 Caenorhabditis japonica (nematode) CPIJ009720 Culex pipens (mosquito) ENSCPOP00000006698 Cavia porcellus (guinea pig) RP30760 Caenorhabditis remanei (nematode) ENSCSAVP00000008365 Ciona savignyi (sedentary tunicate) 167403 Capitella spl (polychaete worm) ENSDARP00000086327 Danio rerio (zebra fish) ENSECAP00000020639 Equus caballus (horse) ENSGACP00000015208 Gymnopilus aculeatus (mushroom) ENSGALP00000000333 Gallus gallus (chicken) 110840 Hypsipyla robusta (cedar shoot borer) ENSP00000261483 Homo sapiens (human) ISCW018027-PA Ixodes scapularis (deer tick) 188902 Lottia gigantea (owl limpet) ENSMODP00000024280 Monodelphis domestica (gray opossum) ENSMMUP00000004423 Macaca mulatta (rhesus monkey) ENSMUSP00000083928 Mus musculus (house mouse) 166900 Nematostella vectensis (starlet anemone) XP_001601023.1 Nasonia vitripennis (wasp) ENSOANP00000018059 Ornithorynchus anatinus (platypus) ENSORLP00000014907 Oryzias latipes (japanese killifish) LOC_Os06g13650.1 Oryza sativa (asian rice) PHUM003705-PA Pediculus humanus (human body louse) PP23662 Pristionchus pacificus (nematode) 159159 Physcomitrella patens (moss) ENSPPYP00000017527 Pongo pygmaeus (orangutan) 549487 Populus trichocarpa (black cottonwood) ENSPTRP00000048125 Pan troglodytes (chimpanzee) ENSRNOP00000020767 Rattus norvegicus (norway rat) 5061581 Sorghum bicolor (sorghum) Smp_143430 Schistosoma mansoni (trematode parasite) 60265 Trichoplax adhaerens (metazoa) XP_972030.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015129 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000001660 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033737 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41126 modMine - Data generated by the modENCODE project. • FBgn0011740 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14616 NV15211 LH20387 ISCW018027 FBgn0242997 FBgn0212967 FBgn0210737 FBgn0190137 FBgn0178669 FBgn0075110 FBgn0151427 FBgn0146733 FBgn0125902 FBgn0109006 FBgn0094231 CPIJ009720 BGIBMGA005142 ACYPI009717 GB19751 AGAP004020 AAEL011978 PHUM459490 GLEAN_09186
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	alpha-Man-II (Giot et al., 2003, Ford et al., 2007) CG8139   CG18474   CG18802   dGMII (Shah et al., 2003, Numao et al., 2003, Dunne et al., 2002, Landis et al., 2001, van den Elsen et al., 2001, Rabouille et al., 1999, Shah et al., 2008, Wen et al., 2005, Kuntz et al., 2008) dGMIIb (Poláková et al., 2011) DM-GII.1 (Gonzalez and Jordan, 2000) GMII (Farkas et al., 2003, Roberts, 1999.2.1, Roberts et al., 1998, Tchoubrieva and Roberts, 1997, Giansanti et al., 2006) GmII (Foster et al., 1995) Man (Chen et al., 2006) MAN-2 (Choudhary et al., 1992) α-Man-II (Liu and Lehmann, 2008, Cao et al., 2011)
Name Synonym	alpha-mannosidase II (Aigaki et al., 2002, Foster, 1994.2.8) Golgi Man II (Foster et al., 1995) Golgi mannosidase II (Tchoubrieva and Roberts, 1997) Golgi α-mannosidase II (Shah et al., 2008, Kuntz et al., 2008, Poláková et al., 2011) mannosidase II (Kondylis et al., 2001) α-mannosidase 2 (Cox and Spradling, 2003) α Mannosidase II (Kuntz et al., 2010) α mannosidase II (Giansanti et al., 2006) α-mannosidase II (Wen et al., 2005)
Secondary FlyBase IDs
	FBgn0037691 FBgn0042203
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Cao et al., 2011, EMBO J. 30(18): 3701--3713 A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. [FBrf0215269] Poláková et al., 2011, Eur. J. Med. Chem. 46(3): 944--952 α-d-Mannose derivatives as models designed for selective inhibition of Golgi α-mannosidase II. [FBrf0213098] Kuntz et al., 2010, Chembiochem 11(5): 673--680 Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. [FBrf0210848] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...