FlyBase Gene Report: Dmel\Arp1

General Information

Symbol

Dmel\Arp1

Species

D. melanogaster

Name

Actin-related protein 1

Annotation Symbol

CG6174

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011745

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Actin-related protein 1 (Arp1) encodes the short filamentous component of the Dynactin complex, which plays an essential role in the activation of the Dynein microtubule motor protein. As such, the Arp1 product is required for diverse cellular processes such as intracellular transport, mitotic spindle assembly, chromosome movements, and nuclear positioning. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Arp87C, gridlock, grid, Actin-related protein 87C

Key Links

Genomic Location

Cytogenetic map

87C5-87C5

Sequence location

3R:12,691,743..12,694,232 [+]

Recombination map

3-52

RefSeq locus

NT_033777 REGION:12691743..12694232

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in anterograde axonal transport

inferred from mutant phenotype

(Haghnia et al., 2007)

involved_in axonal transport of mitochondrion

inferred from mutant phenotype

(Haghnia et al., 2007)

involved_in microtubule-based movement

inferred from direct assay

(Eckley and Schroer, 2003)

involved_in mitotic cell cycle

inferred from high throughput mutant phenotype

(Ducat et al., 2008)

involved_in retrograde axonal transport

inferred from mutant phenotype

(Haghnia et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of dynactin complex

inferred from biological aspect of ancestor with PANTHER:PTN000233666

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ACTIN-RELATED PROTEINS

DYNACTIN COMPLEX

Protein Family (UniProt)

Belongs to the actin family. ARP1 subfamily. (P45889)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ACTIN-RELATED PROTEINS -: Actin-related proteins (Arp) share significant sequence identity with actins. Arps broadly fall into two groups: nuclear Arps, involved in chromatin remodeling; and cytoplasmic Arps, associated with actin. (Adapted from PMID:21859859).
DYNACTIN COMPLEX -: Dynactin is a large 1.2 MDa multisubunit protein complex that associates with the cytoplasmic dynein complex to drive microtubule-based transport. (Adapted from PMID:15473859 and PMID:25751425).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Arp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P45889)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Arp1-RA

FBtr0082652

NM_079607

1469

376

Additional Transcript Data and Comments

Reported size (kB)

1.131 (longest cDNA)

(Fyrberg et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Arp1-PA

FBpp0082121

42.7

376

7.34

P45889

NP_524331

AAF54853

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

376 (aa)

(Fyrberg et al., 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P45889

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arp1 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.67

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Arp1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Arp1

View exonic expression by tissue for Dmel\Arp1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011745

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41566/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011745

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011745

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011745

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6174

Flygut - An atlas of the Drosophila adult midgut

FBgn0011745

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Arp1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Arp1

Transgenic constructs containing regulatory region of Arp1

Aberrations (Deficiencies and Duplications) ( 12 )

Inferred from experimentation ( 12 )

Gene disrupted in

Df(3R)ED5610

(Nieuwburg et al., 2017)

Df(3R)Exel6166

(Nieuwburg et al., 2017, Ryder, 2004.4.26)

Df(3R)ry81

(Nieuwburg et al., 2017)

Df(3R)ry615

(Fyrberg et al., 1994)

Gene not disrupted in

Df(3R)ED5518

(Nieuwburg et al., 2017)

Df(3R)ED5612

(Nieuwburg et al., 2017)

Df(3R)ED5644

(Nieuwburg et al., 2017)

Df(3R)ED5664

(Nieuwburg et al., 2017)

Df(3R)ED5705

(Nieuwburg et al., 2017)

Df(3R)ED5780

(Nieuwburg et al., 2017)

Df(3R)Exel7316

(Nieuwburg et al., 2017)

Df(3R)Exel7317

(Nieuwburg et al., 2017)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

Arp1¹

lethal - all die during embryonic stage | germline clone | maternal effect

Arp1^4D2

partially lethal (with Arp1¹)

Arp1^4D2

partially lethal (with Arp1²)

Arp1^4D2

partially lethal (with Arp1^4D2)

Other Phenotypes

Allele

abnormal locomotor behavior | larval stage

Arp1¹

abnormal mitotic cell cycle | larval stage

Arp1¹

increased cell death | larval stage

Arp1¹

Phenotype manifest in

Allele

germarium | germline clone

Arp1^c04425

larval brain

Arp1¹

larval neuroblast

Arp1¹

microtubule | oogenesis

Arp1^4D2

oocyte

Arp1^4D2

oocyte | germline clone

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (42)

Hsap\ACTR1A

14 of 14

Yes

Hsap\ACTR1B

12 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Actr1a

14 of 14

Yes

Rnor\Actr1b

12 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Potef

1 of 14

Mus musculus (laboratory mouse) (27)

Mmus\Actr1a

14 of 14

Yes

Mmus\Actr1b

12 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (15)

Xtro\acta1

3 of 13

Yes

Xtro\acta4

3 of 13

Yes

Xtro\actb

3 of 13

Yes

Xtro\actc1

3 of 13

Yes

Xtro\actg1

3 of 13

Yes

Xtro\acta2

2 of 13

Xtro\actr1a

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (22)

Drer\actr1b

13 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch211-241j12.3

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\arp-1

13 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP002127

12 of 12

Yes

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\ACT1

4 of 13

Yes

Atha\ACT2

4 of 13

Yes

Atha\ACT3

4 of 13

Yes

Atha\ACT4

4 of 13

Yes

Atha\ACT7

4 of 13

Yes

Atha\ACT8

4 of 13

Yes

Atha\ACT9

4 of 13

Yes

Atha\ACT11

4 of 13

Yes

Atha\ACT12

4 of 13

Yes

Atha\AT2G42100

4 of 13

Yes

Atha\AT2G42170

4 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\ARP1

5 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\arp1

5 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Arp1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ACTR1A; actin related protein 1A

14 of 14

605143

ACTR1B; actin related protein 1B

12 of 14

605144

ACTA1; actin alpha 1, skeletal muscle

4 of 14

102610

ACTBL2; actin beta like 2

4 of 14

614835

ACTC1; actin alpha cardiac muscle 1

4 of 14

102540

ACTRT3; actin related protein T3

4 of 14

608534

ACTA2; actin alpha 2, smooth muscle

3 of 14

102620

ACTB; actin beta

3 of 14

102630

Baraitser-Winter syndrome 1

ACTG1; actin gamma 1

3 of 14

102560

ACTG2; actin gamma 2, smooth muscle

3 of 14

102545

megacystis-microcolon-intestinal hypoperistalsis syndrome

ACTL8; actin like 8

3 of 14

ACTL9; actin like 9

3 of 14

619251

SPERMATOGENIC FAILURE 53; SPGF53

spermatogenic failure 53

ACTR2; actin related protein 2

3 of 14

604221

ACTRT1; actin related protein T1

3 of 14

300487

ACTRT2; actin related protein T2

3 of 14

608535

POTEE; POTE ankyrin domain family member E

3 of 14

608914

POTEI; POTE ankyrin domain family member I

3 of 14

POTEJ; POTE ankyrin domain family member J

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Arp1 - Arp10

experimental knowledge based

(Guruharsha et al., 2011)

Arp1 - DCTN1-p150

experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot

(Guruharsha et al., 2011, Kim et al., 2007)

Arp1 - DCTN2-p50

experimental knowledge based

(Guruharsha et al., 2011)

Arp1 - DCTN4-p62

experimental knowledge based

(Guruharsha et al., 2011)

Arp1 - DCTN5-p25

experimental knowledge based

(Guruharsha et al., 2011)

Arp1 - DCTN6-p27

experimental knowledge based

(Guruharsha et al., 2011)

Arp1 - LRR

experimental knowledge based

(Guruharsha et al., 2011)

Arp1 - Nuf2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2007)

Arp1 - shot

pull down, anti tag western blot

(Dewey and Johnston, 2017)

RNA-protein

Physical Interaction

Assay

References

Arp1 - fs(1)K10

pull down, peptide massfingerprinting

(Dix et al., 2013)

Arp1 - hry

pull down, peptide massfingerprinting

(Dix et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CycB

suppressible

Arp1

(Ji et al., 2002)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66659

DroID - A comprehensive database of gene and protein interactions.

FBgn0011745

MIST (genetic) - An integrated Molecular Interaction Database

41566

MIST (protein-protein) - An integrated Molecular Interaction Database

41566

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P45889

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-52

Cytogenetic map

87C5-87C5

Sequence location

3R:12,691,743..12,694,232 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87C5-87C5

Limits computationally determined from genome sequence between P{lacW}Vha55^j2E9 and P{PZ}CtBP⁰³⁴⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

87C-87C

(Haghnia et al., 1999, Fyrberg, 1994.3.15)

87C-87C

(determined by in situ hybridisation)

(Fyrberg et al., 1994)

Experimentally Determined Recombination Data

Location

3-52

(FlyBase, 2016)

3-50.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

30044

w¹¹¹⁸; P{EP}Arp1^G3709/TM6C, Sb¹

11424

w¹¹¹⁸; PBac{PB}Arp1^c04425/TM6B, Tb¹

67932

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05735}attP40

57944

y¹ w^*; Mi{MIC}Arp1^MI12442/TM3, Sb¹ Ser¹

NIG-Fly

6174R-2

P{NIG.6174R}2

6174R-3

P{NIG.6174R}3

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (139)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH04757

Other clones

DPiM_RH04757

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011745

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011745

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Haghnia et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The dynactin complex, (which contains Gl and Arp87C) functions locally within the presynaptic arbor to promote synapse stability.

(Eaton et al., 2002)

Mutant larvae show progressive distal paralysis that causes them to flip their tails upward as they crawl. Axonal transport defects are seen.

(Haghnia et al., 1999)

Isolation and characterisation of actin-related proteins Arp14D, Arp53D, Arp66B and Arp87C.

(Fyrberg et al., 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: Arp87C grid

(Haghnia et al., 2000)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Arp1 Arp87C

(FlyBase, 2009-)

Nomenclature comments

'Arp87C' renamed to 'Arp1' to rationalize the nomenclature of Actin-related protein (Arp) genes (by orthology with the mammalian and yeast genes).

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

ARP1

(Haghnia et al., 2002, Tekotte and Davis, 2002, Haghnia et al., 2001, Goldstein and Gunawardena, 2000, Haghnia et al., 2000)

ARP87C

(Fisher et al., 2008, Fyrberg, 1994.3.15)

Actr87C

Arp

(Deak et al., 1997)

Arp-1

(Eaton et al., 2002)

Arp1

(Barbaste et al., 2023, Schroeder et al., 2020, Noble et al., 2016, Kollmar, 2015.9.15, Kollmar, 2015.9.21, Chang et al., 2013, Dix et al., 2013, Hammesfahr and Kollmar, 2012, Reis et al., 2012, Kim et al., 2007, Kollmar and Odronitz, 2006, Haghnia and Goldstein, 2001, Ji et al., 2001)

Arp87C

(Butzlaff et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Joyce et al., 2012, Reis et al., 2012, Przewloka et al., 2007)

Arp87c

(Schnall-Levin et al., 2010)

CG6174

(Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Perkins et al., 2009, Ducat et al., 2008, Hughes et al., 2008, Przewloka et al., 2007, Eckley and Schroer, 2003, Goldstein and Gunawardena, 2000)

arp-1

(Dewey and Johnston, 2017)

arp1

(O'Farrell et al., 2023, Nashchekin et al., 2021, Nieuwburg et al., 2017, Reis et al., 2012, Haghnia et al., 2007, Frankel and Mooseker, 1996)

gdl

(Haghnia et al., 1999)

grid

(Reis et al., 2012, Haghnia et al., 2002, Haghnia et al., 2000, Haghnia et al., 1999)

Name Synonyms

Actin related protein 1

(Kollmar, 2015.9.15)

Actin-related protein 1

Actin-related protein 87C

(Ducat et al., 2008, Fyrberg et al., 1994)

actin-related protein 1

(Haghnia et al., 2007)

gridlock

(Haghnia et al., 2007, Haghnia et al., 2002, Haghnia and Goldstein, 2001, Haghnia et al., 2001, Haghnia et al., 1999)

Secondary FlyBase IDs

FBgn0026240

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41566

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P45889

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P45889

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P45889

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011745

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41566/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011745

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011745

FlyMine - An integrated database for Drosophila genomics

FBgn0011745

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6174

MARRVEL_MODEL - MARRVEL (model organism gene)

41566

Linkouts

BioGRID - A database of protein and genetic interactions.

66659

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011745

DroID - A comprehensive database of gene and protein interactions.

FBgn0011745

DRSC - Results frm RNAi screens

FBgn0011745

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011745

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011745

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6174

Flygut - An atlas of the Drosophila adult midgut

FBgn0011745

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011745

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030579

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

MIST (genetic) - An integrated Molecular Interaction Database

41566

MIST (protein-protein) - An integrated Molecular Interaction Database

41566

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P45889

References (85)

The following external sites may use different assemblies or annotations than FlyBase.

0.67

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