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Gene Dmel\Arp1

General Information
Symbol	Dmel\Arp1	Species	D. melanogaster
Name	Actin-related protein 1	Annotation symbol	CG6174
Feature type	protein_coding_gene	FlyBase ID	FBgn0011745
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	ARP87C, grid
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87C5-87C5	Sequence location	3R:8,517,465..8,519,954 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Actin-related protein 1 is referred to in FlyBase by the symbol Dmel\Arp1 (CG6174, FBgn0011745). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton; actin binding. There is experimental evidence that it is involved in the biological process: axon transport of mitochondrion; retrograde axon cargo transport; mitosis; anterograde axon cargo transport. 9 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval brain; synapse; embryonic/larval neuroblast. It has one annotated transcript and one annotated polypeptide. Protein features are: Actin, conserved site; Actin-related protein; Actin/actin-like conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult fat body, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639121_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Arp87C. Gene sequence location is 3R:8517465..8519954.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87C5-87C5   Limits computationally determined from genome sequence between P{lacW}Vha55j2E9 and P{PZ}CtBP03463
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87C-87C     (Fyrberg, 1994.3.15) 87C-87C     (Haghnia et al., 1999) 87C-87C   (determined by in situ hybridisation)   (Fyrberg et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Arp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Arp1-RA FBtr0082652  NM_079607   1469   376
Additional Transcript Data & Comments
Reported size (kB)	1.131 (longest cDNA) (Fyrberg et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Arp1-PA   FBpp0082121   42.7   376   7.34     NP_524331   AAF54853
Additional Polypeptide Data & Comments
Reported size (kDa)	376 (aa) (Fyrberg et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin, conserved site (IPR004001) Actin-related protein (IPR004000) Actin/actin-like conserved site (IPR020902)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140713   AA567402   AA802567   AE014297 AAF54853   AI134601   AI134995   AI239076   AI257733   AI387182   AY070666 AAL48137   BE662165   BE975341   BF501306   BF503332   BF503441   BF504884   BI171184   BI171191   BI171262   BI215302   BI230758   BI243778   BI361583   BI367631   BI369406   BI483054   BI564505   BI564591   BI567987   BI569353   BI569354   BI570618   BI571593   BI571813   BI573089   BI573186   BI573187   BI575680   BI581647   BI581787   BI590348   BI591051   BI591651   BI593161   BI607524   BI611828   BI613809   BI615253   BI618019   BI619542   BI621631   BI624687   BI625972   BI626531   BI634952   BI638227   CK134883   CO154894   CO182770   CO285980   CO286073   CO289035   CO299062   CZ469238   CZ469239   EC069894   EC207345   EC242906   EL885385   EV583348   GH751487   GH754676   GH758754   GH761318   GH774781   GH776331   GH777604   GH778121   GH781420   GH782751   GH786034   GH793113   GH793327   GH793498   GH796374   GH797069   GH797693   GH798106   GH804123   GH806747   GH808494   GH810841   GH813175   GH814794   GH815014   GH820436   GH821268   GH822624   GH824578   GH827292   GH833430   GH833718   GH838550   GH839077   GH839777   GH842992   GH843430   GH845317   GH845551   GH851181   GH852072   GH855320   GH857602   GH859438   GH860323   GH861788   GH862384   GH864449   GH865462   GH868534   GH868915   GH875499   GH881621   GH884645   GH884686   GH887128   GH889662   GH891461   GH894666   GH898977   GH901331   GH904847   GH910799   GH911003   GH912089   GH914558   GH918949   GH919298   GH925617   GH926134   GH926741   GH926892   GH929573   GH930716   GH931012   GH931440   GH934722   GH935309   GH935458   GH938250   GH942303   X78488 CAA55240
UniProtKB/Swiss-Prot	P45889
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult fat body, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    853.725 Larval Midgut    1257.3 Larval Hindgut    1225.1 Larval Malpighian Tubules    1291.7 Larval Fat Body    574 Larval Salivary Gland    1724.9 Larval Trachea    1223.3 Larval Carcass    1078 Adult Head    522.7 Adult Eye    634.775 Adult Brain    677.6 Adult Thoracic-Abdominal Ganglion    981.3 Adult Crop    813 Adult Midgut    977 Adult Hindgut    913.6 Adult Malpighian Tubules    947.6 Adult Fat Body    449.9 Adult Salivary Gland    863 Adult Heart    485.325 Adult VirginFemale Spermatheca    769.2 Adult InseminatedFemale Spermatheca    958.4 Adult Ovary    567.7 Adult Testis    246.6 Adult Male Accessory Gland    696.1 Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (853.725) Larval Midgut  (1257.3) Larval Hindgut  (1225.1) Larval Malpighian Tubules  (1291.7) Larval Fat Body  (574) Larval Salivary Gland  (1724.9) Larval Trachea  (1223.3) Larval Carcass  (1078) Adult Head  522.7 Adult Eye  (634.775) Adult Brain  (677.6) Adult Thoracic-Abdominal Ganglion  (981.3) Adult Crop  (813) Adult Midgut  (977) Adult Hindgut  (913.6) Adult Malpighian Tubules  (947.6) Adult Fat Body    449.9 Adult Salivary Gland  (863) Adult Heart    485.325 Adult VirginFemale Spermatheca  (769.2) Adult InseminatedFemale Spermatheca  (958.4) Adult Ovary  (567.7) Adult Testis    246.6 Adult Male Accessory Gland  (696.1) Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    853.725 Larval Midgut  (1257.3) Larval Hindgut  (1225.1) Larval Malpighian Tubules  (1291.7) Larval Fat Body    574 Larval Salivary Gland  (1724.9) Larval Trachea  (1223.3) Larval Carcass  1078 Adult Head    522.7 Adult Eye    634.775 Adult Brain    677.6 Adult Thoracic-Abdominal Ganglion    981.3 Adult Crop    813 Adult Midgut    977 Adult Hindgut    913.6 Adult Malpighian Tubules    947.6 Adult Fat Body    449.9 Adult Salivary Gland    863 Adult Heart    485.325 Adult VirginFemale Spermatheca    769.2 Adult InseminatedFemale Spermatheca    958.4 Adult Ovary    567.7 Adult Testis    246.6 Adult Male Accessory Gland    696.1 Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    853.725 Larval Midgut    1257.3 Larval Hindgut    1225.1 Larval Malpighian Tubules    1291.7 Larval Fat Body    574 Larval Salivary Gland    1724.9 Larval Trachea    1223.3 Larval Carcass    1078 Adult Head    522.7 Adult Eye    634.775 Adult Brain    677.6 Adult Thoracic-Abdominal Ganglion    981.3 Adult Crop    813 Adult Midgut    977 Adult Hindgut    913.6 Adult Malpighian Tubules    947.6 Adult Fat Body    449.9 Adult Salivary Gland    863 Adult Heart    485.325 Adult VirginFemale Spermatheca    769.2 Adult InseminatedFemale Spermatheca    958.4 Adult Ovary    567.7 Adult Testis    246.6 Adult Male Accessory Gland    696.1 Adult Carcass    462.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    853.725 Larval Midgut    1257.3 Larval Hindgut    1225.1 Larval Malpighian Tubules    1291.7 Larval Fat Body    574 Larval Salivary Gland    1724.9 Larval Trachea    1223.3 Larval Carcass    1078 Adult Head    522.7 Adult Eye    634.775 Adult Brain    677.6 Adult Thoracic-Abdominal Ganglion    981.3 Adult Crop    813 Adult Midgut    977 Adult Hindgut    913.6 Adult Malpighian Tubules    947.6 Adult Fat Body    449.9 Adult Salivary Gland    863 Adult Heart    485.325 Adult VirginFemale Spermatheca    769.2 Adult InseminatedFemale Spermatheca    958.4 Adult Ovary    567.7 Adult Testis    246.6 Adult Male Accessory Gland    696.1 Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (853.725) Larval Midgut  (1257.3) Larval Hindgut  (1225.1) Larval Malpighian Tubules  (1291.7) Larval Fat Body  574 Larval Salivary Gland  (1724.9) Larval Trachea  (1223.3) Larval Carcass  (1078) Adult Head  522.7 Adult Eye  634.775 Adult Brain  677.6 Adult Thoracic-Abdominal Ganglion  (981.3) Adult Crop  813 Adult Midgut  (977) Adult Hindgut  (913.6) Adult Malpighian Tubules  (947.6) Adult Fat Body    449.9 Adult Salivary Gland  (863) Adult Heart    485.325 Adult VirginFemale Spermatheca  769.2 Adult InseminatedFemale Spermatheca  (958.4) Adult Ovary  567.7 Adult Testis    246.6 Adult Male Accessory Gland  696.1 Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    853.725 Larval Midgut  1257.3 Larval Hindgut  1225.1 Larval Malpighian Tubules  1291.7 Larval Fat Body    574 Larval Salivary Gland  (1724.9) Larval Trachea  1223.3 Larval Carcass  1078 Adult Head    522.7 Adult Eye    634.775 Adult Brain    677.6 Adult Thoracic-Abdominal Ganglion    981.3 Adult Crop    813 Adult Midgut    977 Adult Hindgut    913.6 Adult Malpighian Tubules    947.6 Adult Fat Body    449.9 Adult Salivary Gland    863 Adult Heart    485.325 Adult VirginFemale Spermatheca    769.2 Adult InseminatedFemale Spermatheca    958.4 Adult Ovary    567.7 Adult Testis    246.6 Adult Male Accessory Gland    696.1 Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    853.725 Larval Midgut    1257.3 Larval Hindgut    1225.1 Larval Malpighian Tubules    1291.7 Larval Fat Body    574 Larval Salivary Gland    1724.9 Larval Trachea    1223.3 Larval Carcass    1078 Adult Head    522.7 Adult Eye    634.775 Adult Brain    677.6 Adult Thoracic-Abdominal Ganglion    981.3 Adult Crop    813 Adult Midgut    977 Adult Hindgut    913.6 Adult Malpighian Tubules    947.6 Adult Fat Body    449.9 Adult Salivary Gland    863 Adult Heart    485.325 Adult VirginFemale Spermatheca    769.2 Adult InseminatedFemale Spermatheca    958.4 Adult Ovary    567.7 Adult Testis    246.6 Adult Male Accessory Gland    696.1 Adult Carcass    462.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    522.7   NA  Eye    634.775   NA  Brain    677.6   853.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    981.3   NA  Crop    813   1257.3  Midgut    977   1225.1  Hindgut    913.6   1291.7  Malpighian Tubules    947.6   574  Fat Body    449.9   1724.9  Salivary Gland    863   NA  Heart    485.325   1223.3  Trachea    NA   NA  VirginFemale Spermatheca    769.2   NA  InseminatedFemale Spermatheca    958.4   NA  Ovary    567.7   NA  Testis    246.6   NA  Male Accessory Gland    696.1   1078  Carcass    462.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    55 central nervous system, pupae P8    41 head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female    27 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    21 head, mated 1-day male    33 head, mated 4-day male    39 head, mated 20-day male    46 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    61 digestive system, 1-day adult    54 digestive system, 4-day adult    40 digestive system, 20-day adult    40 fat body, larvae L3 wandering    8 fat body, white prepupae    26 fat body, pupae P8    33 carcass, larvae L3 wandering    49 carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female    55 ovary, mated 4-day female    37 testis, mated 4-day male    41 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (55) central nervous system, pupae P8  (41) head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female  (27) head, mated 1-day female    23 head, mated 4-day female  (27) head, mated 20-day female    21 head, mated 1-day male  (33) head, mated 4-day male  (39) head, mated 20-day male  (46) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (65) digestive system, larvae L3 wandering  (61) digestive system, 1-day adult  (54) digestive system, 4-day adult  (40) digestive system, 20-day adult  (40) fat body, larvae L3 wandering    8 fat body, white prepupae  26 fat body, pupae P8  (33) carcass, larvae L3 wandering  (49) carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (37) testis, mated 4-day male  (41) accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    55 central nervous system, pupae P8    41 head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female    27 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    21 head, mated 1-day male    33 head, mated 4-day male    39 head, mated 20-day male    46 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    61 digestive system, 1-day adult    54 digestive system, 4-day adult    40 digestive system, 20-day adult    40 fat body, larvae L3 wandering    8 fat body, white prepupae    26 fat body, pupae P8    33 carcass, larvae L3 wandering    49 carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female    55 ovary, mated 4-day female    37 testis, mated 4-day male    41 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    55 central nervous system, pupae P8    41 head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female    27 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    21 head, mated 1-day male    33 head, mated 4-day male    39 head, mated 20-day male    46 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    61 digestive system, 1-day adult    54 digestive system, 4-day adult    40 digestive system, 20-day adult    40 fat body, larvae L3 wandering    8 fat body, white prepupae    26 fat body, pupae P8    33 carcass, larvae L3 wandering    49 carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female    55 ovary, mated 4-day female    37 testis, mated 4-day male    41 accessory gland, mated 4-day male    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    55 central nervous system, pupae P8    41 head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female    27 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    21 head, mated 1-day male    33 head, mated 4-day male    39 head, mated 20-day male    46 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    61 digestive system, 1-day adult    54 digestive system, 4-day adult    40 digestive system, 20-day adult    40 fat body, larvae L3 wandering    8 fat body, white prepupae    26 fat body, pupae P8    33 carcass, larvae L3 wandering    49 carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female    55 ovary, mated 4-day female    37 testis, mated 4-day male    41 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (55) central nervous system, pupae P8  (41) head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female  27 head, mated 1-day female    23 head, mated 4-day female  27 head, mated 20-day female    21 head, mated 1-day male  (33) head, mated 4-day male  (39) head, mated 20-day male  (46) salivary gland, larvae L3 wandering    23 salivary gland, white prepupae  (65) digestive system, larvae L3 wandering  (61) digestive system, 1-day adult  (54) digestive system, 4-day adult  (40) digestive system, 20-day adult  (40) fat body, larvae L3 wandering    8 fat body, white prepupae  26 fat body, pupae P8  (33) carcass, larvae L3 wandering  (49) carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (37) testis, mated 4-day male  (41) accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    55 central nervous system, pupae P8    41 head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female    27 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    21 head, mated 1-day male    33 head, mated 4-day male    39 head, mated 20-day male    46 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    61 digestive system, 1-day adult    54 digestive system, 4-day adult    40 digestive system, 20-day adult    40 fat body, larvae L3 wandering    8 fat body, white prepupae    26 fat body, pupae P8    33 carcass, larvae L3 wandering    49 carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female    55 ovary, mated 4-day female    37 testis, mated 4-day male    41 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    55 central nervous system, pupae P8    41 head, virgin 1-day female    24 head, virgin 4-day female    20 head, virgin 20-day female    27 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    21 head, mated 1-day male    33 head, mated 4-day male    39 head, mated 20-day male    46 salivary gland, larvae L3 wandering    23 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    61 digestive system, 1-day adult    54 digestive system, 4-day adult    40 digestive system, 20-day adult    40 fat body, larvae L3 wandering    8 fat body, white prepupae    26 fat body, pupae P8    33 carcass, larvae L3 wandering    49 carcass, 1-day adult    21 carcass, 4-day adult    19 carcass, 20-day adult    19 ovary, virgin 4-day female    55 ovary, mated 4-day female    37 testis, mated 4-day male    41 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    34 embryo 04-06hr    56 embryo 06-08hr    66 embryo 08-10hr    64 embryo 10-12hr    85 embryo 12-14hr    53 embryo 14-16hr    58 embryo 16-18hr    49 embryo 18-20hr    49 embryo 20-22hr    59 embryo 22-24hr    55 larva L1    62 larva L2    85 larva L3 12hr old    70 larva L3 puffstage 1-2    76 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    102 white prepupae new    107 white prepupae 12hr    103 white prepupae 24hr    90 pupae 2d postWPP    77 pupae 3d postWPP    58 pupae 4d postWPP    74 adult male 01day    56 adult male 05day    56 adult male 30day    53 adult female 01day    75 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (95) embryo 02-04hr  (34) embryo 04-06hr  (56) embryo 06-08hr  (66) embryo 08-10hr  (64) embryo 10-12hr  (85) embryo 12-14hr  (53) embryo 14-16hr  (58) embryo 16-18hr  (49) embryo 18-20hr  (49) embryo 20-22hr  (59) embryo 22-24hr  (55) larva L1  (62) larva L2  (85) larva L3 12hr old  (70) larva L3 puffstage 1-2  (76) larva L3 puffstage 3-6  (80) larva L3 puffstage 7-9  (102) white prepupae new  (107) white prepupae 12hr  (103) white prepupae 24hr  (90) pupae 2d postWPP  (77) pupae 3d postWPP  (58) pupae 4d postWPP  (74) adult male 01day  (56) adult male 05day  (56) adult male 30day  (53) adult female 01day  (75) adult female 05day  (84) adult female 30day  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    34 embryo 04-06hr    56 embryo 06-08hr    66 embryo 08-10hr    64 embryo 10-12hr    85 embryo 12-14hr    53 embryo 14-16hr    58 embryo 16-18hr    49 embryo 18-20hr    49 embryo 20-22hr    59 embryo 22-24hr    55 larva L1    62 larva L2    85 larva L3 12hr old    70 larva L3 puffstage 1-2    76 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9  102 white prepupae new  107 white prepupae 12hr  103 white prepupae 24hr    90 pupae 2d postWPP    77 pupae 3d postWPP    58 pupae 4d postWPP    74 adult male 01day    56 adult male 05day    56 adult male 30day    53 adult female 01day    75 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    34 embryo 04-06hr    56 embryo 06-08hr    66 embryo 08-10hr    64 embryo 10-12hr    85 embryo 12-14hr    53 embryo 14-16hr    58 embryo 16-18hr    49 embryo 18-20hr    49 embryo 20-22hr    59 embryo 22-24hr    55 larva L1    62 larva L2    85 larva L3 12hr old    70 larva L3 puffstage 1-2    76 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    102 white prepupae new    107 white prepupae 12hr    103 white prepupae 24hr    90 pupae 2d postWPP    77 pupae 3d postWPP    58 pupae 4d postWPP    74 adult male 01day    56 adult male 05day    56 adult male 30day    53 adult female 01day    75 adult female 05day    84 adult female 30day    87 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    34 embryo 04-06hr    56 embryo 06-08hr    66 embryo 08-10hr    64 embryo 10-12hr    85 embryo 12-14hr    53 embryo 14-16hr    58 embryo 16-18hr    49 embryo 18-20hr    49 embryo 20-22hr    59 embryo 22-24hr    55 larva L1    62 larva L2    85 larva L3 12hr old    70 larva L3 puffstage 1-2    76 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    102 white prepupae new    107 white prepupae 12hr    103 white prepupae 24hr    90 pupae 2d postWPP    77 pupae 3d postWPP    58 pupae 4d postWPP    74 adult male 01day    56 adult male 05day    56 adult male 30day    53 adult female 01day    75 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (95) embryo 02-04hr  (34) embryo 04-06hr  (56) embryo 06-08hr  (66) embryo 08-10hr  (64) embryo 10-12hr  (85) embryo 12-14hr  (53) embryo 14-16hr  (58) embryo 16-18hr  (49) embryo 18-20hr  (49) embryo 20-22hr  (59) embryo 22-24hr  (55) larva L1  (62) larva L2  (85) larva L3 12hr old  (70) larva L3 puffstage 1-2  (76) larva L3 puffstage 3-6  (80) larva L3 puffstage 7-9  (102) white prepupae new  (107) white prepupae 12hr  (103) white prepupae 24hr  (90) pupae 2d postWPP  (77) pupae 3d postWPP  (58) pupae 4d postWPP  (74) adult male 01day  (56) adult male 05day  (56) adult male 30day  (53) adult female 01day  (75) adult female 05day  (84) adult female 30day  (87) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    34 embryo 04-06hr    56 embryo 06-08hr    66 embryo 08-10hr    64 embryo 10-12hr    85 embryo 12-14hr    53 embryo 14-16hr    58 embryo 16-18hr    49 embryo 18-20hr    49 embryo 20-22hr    59 embryo 22-24hr    55 larva L1    62 larva L2    85 larva L3 12hr old    70 larva L3 puffstage 1-2    76 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9  102 white prepupae new  107 white prepupae 12hr  103 white prepupae 24hr    90 pupae 2d postWPP    77 pupae 3d postWPP    58 pupae 4d postWPP    74 adult male 01day    56 adult male 05day    56 adult male 30day    53 adult female 01day    75 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    95 embryo 02-04hr    34 embryo 04-06hr    56 embryo 06-08hr    66 embryo 08-10hr    64 embryo 10-12hr    85 embryo 12-14hr    53 embryo 14-16hr    58 embryo 16-18hr    49 embryo 18-20hr    49 embryo 20-22hr    59 embryo 22-24hr    55 larva L1    62 larva L2    85 larva L3 12hr old    70 larva L3 puffstage 1-2    76 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    102 white prepupae new    107 white prepupae 12hr    103 white prepupae 24hr    90 pupae 2d postWPP    77 pupae 3d postWPP    58 pupae 4d postWPP    74 adult male 01day    56 adult male 05day    56 adult male 30day    53 adult female 01day    75 adult female 05day    84 adult female 30day    87 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    139 Schneider line 2 Sg4    109 embryonic 1182-4H    80 embryonic GM2    111 embryonic Kc167    60 embryonic S1    105 embryonic S3    95 leg disc CME L1    86 wing disc CME-W2    113 wing disc ML-DmD8    50 wing disc ML-DmD9    83 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    113 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    109 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    73 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    95 tumorous blood cells mbn2    68 ovary fGS/OSS    51 ovary OSC    55 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (139) Schneider line 2 Sg4  (109) embryonic 1182-4H  (80) embryonic GM2  (111) embryonic Kc167  (60) embryonic S1  (105) embryonic S3  (95) leg disc CME L1  (86) wing disc CME-W2  (113) wing disc ML-DmD8  (50) wing disc ML-DmD9  (83) wing disc ML-DmD16-c3  (70) wing disc ML-DmD21  (113) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (109) eye-antennal disc ML-DmD11  (83) antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1  (73) CNS ML-DmBG1-c1  (68) CNS ML-DmBG2-c2  (95) tumorous blood cells mbn2  (68) ovary fGS/OSS  (51) ovary OSC  (55) ovary OSS  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (139) Schneider line 2 Sg4  (109) embryonic 1182-4H    80 embryonic GM2  (111) embryonic Kc167    60 embryonic S1  105 embryonic S3    95 leg disc CME L1    86 wing disc CME-W2  (113) wing disc ML-DmD8    50 wing disc ML-DmD9    83 wing disc ML-DmD16-c3    70 wing disc ML-DmD21  (113) wing disc ML-DmD32    81 haltere disc ML-DmD17-c3  (109) eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1    73 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    95 tumorous blood cells mbn2    68 ovary fGS/OSS    51 ovary OSC    55 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    139 Schneider line 2 Sg4    109 embryonic 1182-4H    80 embryonic GM2    111 embryonic Kc167    60 embryonic S1    105 embryonic S3    95 leg disc CME L1    86 wing disc CME-W2    113 wing disc ML-DmD8    50 wing disc ML-DmD9    83 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    113 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    109 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    73 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    95 tumorous blood cells mbn2    68 ovary fGS/OSS    51 ovary OSC    55 ovary OSS    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    139 Schneider line 2 Sg4    109 embryonic 1182-4H    80 embryonic GM2    111 embryonic Kc167    60 embryonic S1    105 embryonic S3    95 leg disc CME L1    86 wing disc CME-W2    113 wing disc ML-DmD8    50 wing disc ML-DmD9    83 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    113 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    109 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    73 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    95 tumorous blood cells mbn2    68 ovary fGS/OSS    51 ovary OSC    55 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (139) Schneider line 2 Sg4  (109) embryonic 1182-4H  (80) embryonic GM2  (111) embryonic Kc167  (60) embryonic S1  (105) embryonic S3  (95) leg disc CME L1  (86) wing disc CME-W2  (113) wing disc ML-DmD8  (50) wing disc ML-DmD9  (83) wing disc ML-DmD16-c3  (70) wing disc ML-DmD21  (113) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (109) eye-antennal disc ML-DmD11  (83) antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1  (73) CNS ML-DmBG1-c1  (68) CNS ML-DmBG2-c2  (95) tumorous blood cells mbn2  (68) ovary fGS/OSS  (51) ovary OSC  (55) ovary OSS  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  139 Schneider line 2 Sg4  109 embryonic 1182-4H    80 embryonic GM2  111 embryonic Kc167    60 embryonic S1  105 embryonic S3    95 leg disc CME L1    86 wing disc CME-W2  113 wing disc ML-DmD8    50 wing disc ML-DmD9    83 wing disc ML-DmD16-c3    70 wing disc ML-DmD21  113 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3  109 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1    73 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    95 tumorous blood cells mbn2    68 ovary fGS/OSS    51 ovary OSC    55 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    139 Schneider line 2 Sg4    109 embryonic 1182-4H    80 embryonic GM2    111 embryonic Kc167    60 embryonic S1    105 embryonic S3    95 leg disc CME L1    86 wing disc CME-W2    113 wing disc ML-DmD8    50 wing disc ML-DmD9    83 wing disc ML-DmD16-c3    70 wing disc ML-DmD21    113 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    109 eye-antennal disc ML-DmD11    83 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    73 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    95 tumorous blood cells mbn2    68 ovary fGS/OSS    51 ovary OSC    55 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    46 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    62 Rotenone 8 μg 12 hrs, larvae L3    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (46) Cadmium 50 mM 12 hrs, larvae L3  (60) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3  (29) Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (46) Ethanol 5% 3 hrs, larvae L3  (60) Ethanol 10% 3 hrs, larvae L3  (52) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (43) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3  (62) Rotenone 8 μg 12 hrs, larvae L3  (65) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    46 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    62 Rotenone 8 μg 12 hrs, larvae L3    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    46 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    62 Rotenone 8 μg 12 hrs, larvae L3    65 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    46 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    62 Rotenone 8 μg 12 hrs, larvae L3    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (46) Cadmium 50 mM 12 hrs, larvae L3  (60) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3  29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (46) Ethanol 5% 3 hrs, larvae L3  (60) Ethanol 10% 3 hrs, larvae L3  (52) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (43) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3  (62) Rotenone 8 μg 12 hrs, larvae L3  (65) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    46 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    62 Rotenone 8 μg 12 hrs, larvae L3    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    24 cold shock, 4-day adult    19 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    46 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    46 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    62 Rotenone 8 μg 12 hrs, larvae L3    65 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RH04757 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011745 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6174-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Arp1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone Arp11 Other Phenotypes Allele increased cell death | larval stage Arp11 locomotor behavior defective | larval stage Arp11 mitotic cell cycle defective | larval stage Arp11 Phenotype manifest in Allele embryonic/larval brain Arp11 embryonic/larval neuroblast Arp11 oocyte | germline clone Arp11 synapse Arp1dsRNA.cEa
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Arp1 Class Mutagen Stocks Known lesion Arp1c04425 piggyBac transposase 2 -- Arp1G3709 P-element activity 1 -- Arp11 ethyl methanesulfonate 0 Yes Arp12 ethyl methanesulfonate 0 Yes Arp1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Arp1 Class Mutagen Stocks Known lesion Arp1HM05259 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Arp1dsRNA.cEa in vitro construct - RNAi 0 Yes Arp1GD16647 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Arp1NIG.6174R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6166 (Ryder, 2004.4.26) Df(3R)ry615 (Fyrberg et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.6174R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Arp1c04425 NA insertion of mobile activating element P{EP}Arp1G3709 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
anterograde axon cargo transport inferred from mutant phenotype (Haghnia et al., 2007) axon transport of mitochondrion inferred from mutant phenotype (Haghnia et al., 2007) mitosis inferred from mutant phenotype (Ducat et al., 2008) retrograde axon cargo transport inferred from mutant phenotype (Haghnia et al., 2007)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity with Saccharomyces ARP1 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR004001 (FlyBase Curators et al., 2004-) structural constituent of cytoskeleton inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with Saccharomyces ARP1 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
actin cytoskeleton non-traceable author statement (Swiss-Prot Project Members, 1995.9.1) actin filament inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) dynactin complex inferred from sequence or structural similarity with Saccharomyces ARP1 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Arp1 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Arp10 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Arp1 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG12042 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp1 - CG12129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG12237 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG12241 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG12333 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG12659 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG1399 experimental knowledge based (Guruharsha et al., 2011) Arp1 - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG15484 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG2469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG3523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG4004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG4338 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG4858 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG5190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG5525 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG5961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG6073 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG7048 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG7770 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - CG8258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Cen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Cyp12d1-p anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Dmn anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp1 - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Gl experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Arp1 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Grp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Hsp67Bc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Myo61F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Nle anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Pex14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosα7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosβ3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosβ5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Prosβ7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rab18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - RpS10a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpn1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpn2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpn3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - TfIIEα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - cpb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - dpa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - dyn-p25 experimental knowledge based (Guruharsha et al., 2011) Arp1 - fax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - hop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - hyd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - l(2)06496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - l(2)37Ce anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Arp1 - l(3)01239 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mRpS7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mgr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - ox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - slmb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - smid anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - vnc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - wal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Arp1 - βggt-II anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Arp1 allele Gene References Arp87Cunspecified CycB (Ji et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66659 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011745 DroID - A comprehensive database of gene and protein interactions. • FBgn0011745 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41566 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P45889
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N8RQN Dipteran inclusive ortholog search EOG6WDDMB Insect inclusive ortholog search EOG6Z0925 Arthropod inclusive ortholog search EOG63N5V5 Metazoa inclusive ortholog search EOG6WMHN8
Orthologs in Drosophila Species (EOG6N8RQN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Arp1     Drosophila simulans   Dsim\GD18855 Y   Drosophila sechellia   Dsec\GM24057 Y   Drosophila erecta   Dere\GG19181 Y   Drosophila yakuba   Dyak\GE26215 Y   Drosophila ananassae   Dana\GF17116 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19410 Y   Drosophila persimilis   Dper\GL24422 Y   Drosophila willistoni   Dwil\GK13729 Y   Drosophila virilis   Dvir\GJ23183 Y   Drosophila mojavensis   Dmoj\GI10502 Y   Drosophila grimshawi   Dgri\GH21372 Y
Orthologs in non-Drosophila Dipterans (EOG6WDDMB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015309   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003383   Anopheles gambiae Malaria mosquito  Agam\AGAP002127   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001227
Orthologs in non-Dipteran Insects (EOG6Z0925)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC551438   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG030216   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22205   Atta cephalotes Leafcutter ant  Acep\ACEP13643   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20697   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19551   Linepithema humile Argentine ant  Lhum\LH20482   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20340   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006251   Bombyx mori Silkmoth  Bmor\BGIBMGA012151   Pediculus humanus Human body louse  Phum\PHUM515240   Tribolium castaneum Red flour beetle  Tcas\TC030579
Orthologs in non-Insect Arthropods (EOG63N5V5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_203872   Ixodes scapularis Deer tick  Isca\ISCW022123
Orthologs in non-Arthropod Metazoa (EOG6WMHN8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\arp-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001366gn   Danio rerio Zebrafish  Drer\actr1   Xenopus tropicalis Western clawed frog  Xtro\actr1a   Gallus gallus Domestic chicken  Ggal\ACTR1A   Mus musculus House mouse  Mmus\Actr1b   Mus musculus House mouse  Mmus\Actr1a   Rattus norvegicus Norway rat  Rnor\Actr1a   Rattus norvegicus Norway rat  Rnor\Actr1b   Homo sapiens Human  Hsap\ACTR1A   Homo sapiens Human  Hsap\ACTR1B
Human Orthologs (2)
Gene OMIM HGNC Hsap\ACTR1A     Hsap\ACTR1B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18855 Drosophila sechellia Dsec\GM24057 Drosophila erecta Dere\GG19181 Drosophila yakuba Dyak\GE26215 Drosophila ananassae Dana\GF17116 Drosophila pseudoobscura pseudoobscura Dpse\GA19410 Drosophila persimilis Dper\GL24422 Drosophila willistoni Dwil\GK13729 Drosophila virilis Dvir\GJ23183 Drosophila mojavensis Dmoj\GI10502 Drosophila grimshawi Dgri\GH21372
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	30044 w1118; P{EP}Arp1G3709/TM6C, Sb1 32032 y1 sc* v1; P{TRiP.HM05259}attP2 11424 w1118; PBac{PB}Arp1c04425/TM6B, Tb1
Harvard	- PBac{PB}Arp1c04425
Genomic Clones ( 1 )
	BACR07J06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 144 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH04757
Other clones	DPiM_RH04757
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06970 AT16590 AT19295 AT19431 GH12112 GH12602 GH15252 GH17635 GM05842 HL01134 LP06188 RE12885 RE12895 RE12989 RE14790 RE21664 RE41509 RE45865 RE53434 RE55578 RE65889 RH03955 RH05379 RH06847 RH07113 RH08787 RH11110 RH18251 RH19175 RH19485 RH31458 RH39310 RH39933 RH43051 RH44841 RH48531 RH50593 RH53005 RH61804 RH61894 RH64286 RH66494 RH67504 RH74607 SD20461
Other clones	bs41e10 CK01.78D.F12 CK01.79B.A6 CK01.89A.D10 CK00410 Dmel_dig_000325_0667_3727 EC24002 EK061342 EK061635 EK069946 EK174428 EN05005 IP16706 RH01446 RH06513 RH08909 RP003005359 RP003031991 RP003048474 RP003063823 RP003068209 RP003069821 RP003094148 RP003096459 RP003118557 RP003126216 RP003132460 RP003137540 RP003144376 RP003149027 RP003152649 RP003159768 RP003163266 RP003171929 RP003174908 RP003176203 RP003179092 RP003179418 RP003186672 RP003187848 RP003203690 RP003216549 RP003223807 RP003225738 RP003230023 RP003236292 RP003237419 RP003240817 RP003250476 RP003250710 RP003278739 RP003285865 RP003286276 RP003300105 RP003306623 RP003316384 RP003335437 RP003341235 RP003345046 RP003369363 RP003380363 RP003385216 RP003386919 RP003396403 RP003405336 RP003418923 RP003419589 RP003457701 RP003465518 RP003471981 RP003476872 RP003479479 RP003484215 RP003499347 RP003510588 RP003520365 RP003524148 RP003526043 RP003529528 RP003530291 RP003532373 RP003532688 RP003533452 RP003554730 RP003563109 RP003575395 RP003575922 RP003577878 RP003578354 RP003580757 RP003585994 RP003587792 RP003595245 RP003599706 RP003610927 RP003613612 RP003630740
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011745 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41566
Antibody Information
	polyclonal (Haghnia et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Arp1 Arp87C (FlyBase, 2009-)
Source for database merge of	Source for merge of: Arp87C grid (Haghnia et al., 2000)
Additional comments	FlyBase Curator comment: 'Arp87C' renamed to 'Arp1' to rationalize the nomenclature of Actin-related protein (Arp) genes (by orthology with the mammalian and yeast genes). (FlyBase, 2009-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The dynactin complex, (which contains Gl and Arp87C) functions locally within the presynaptic arbor to promote synapse stability. (Eaton et al., 2002) Mutant larvae show progressive distal paralysis that causes them to flip their tails upward as they crawl. Axonal transport defects are seen. (Haghnia et al., 1999) Isolation and characterisation of actin-related proteins Arp14D, Arp53D, Arp66B and Arp87C. (Fyrberg et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079607 RefSeq (Proteins) • NP_524331 DDBJ / EMBL / GenBank • AA802567 AAF54853 AAL48137 AY070666 BE662165 BI591051 CAA55240 CZ469238 CZ469239 X78488 Entrez Gene - A searchable database of RefSeq genes. • 41566 UniProtKB/Swiss-Prot • P45889
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin, conserved site (IPR004001) Actin-related protein (IPR004000) Actin/actin-like conserved site (IPR020902) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH04757
Linkouts
	BioGRID - A database of protein and genetic interactions • 66659 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011745 DroID - A comprehensive database of gene and protein interactions. • FBgn0011745 DRSC - Results from RNAi screens. • FBgn0011745 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011745 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6174-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011745 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41566 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41566 modMine - Data generated by the modENCODE project. • FBgn0011745 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P45889
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	Actr87C   Arp (Deak et al., 1997) ARP1 (Tekotte and Davis, 2002, Haghnia et al., 2002, Haghnia et al., 2001, Goldstein and Gunawardena, 2000, Haghnia et al., 2000) Arp-1 (Eaton et al., 2002) Arp1 (Haghnia and Goldstein, 2001, Ji et al., 2001, Kim et al., 2007, Reis et al., 2012) arp1 (Frankel and Mooseker, 1996, Haghnia et al., 2007, Reis et al., 2012) ARP87C (Fyrberg, 1994.3.15, Fisher et al., 2008) Arp87c (Schnall-Levin et al., 2010) Arp87C (Przewloka et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Reis et al., 2012) CG6174 (Goldstein and Gunawardena, 2000, Przewloka et al., 2007, Ducat et al., 2008, Hughes et al., 2008, Perkins et al., 2009) gdl (Haghnia et al., 1999) grid (Haghnia et al., 2002, Haghnia et al., 2000, Haghnia et al., 1999, Reis et al., 2012)
Name Synonym	actin-related protein 1 (Haghnia et al., 2007) Actin-related protein 1   Actin-related protein 87C (Fyrberg et al., 1994, Ducat et al., 2008) gridlock (Haghnia et al., 2002, Haghnia and Goldstein, 2001, Haghnia et al., 2001, Haghnia et al., 1999, Haghnia et al., 2007)
Secondary FlyBase IDs
	FBgn0026240
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 8 ) Review  ( 3 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 8 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Reis et al., 2012, Mol. Biol. Cell 23(9): 1700--1714 Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. [FBrf0218178] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...