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Gene Dmel\Ank

General Information
Symbol	Dmel\Ank	Species	D. melanogaster
Name	Ankyrin	Annotation symbol	CG1651
Feature type	protein_coding_gene	FlyBase ID	FBgn0011747
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Dank1
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102A3-102A3	Sequence location	4:135,700..150,475 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ankyrin is referred to in FlyBase by the symbol Dmel\Ank (CG1651, FBgn0011747). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process: cytoskeletal anchoring at plasma membrane. 8 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Death domain; Death-like domain; ZU5. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, adult heart, adult fat body, adult salivary gland, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635711_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Ank. Gene sequence location is 4:135700..150475.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102A3-102A3
Experimentally Determined Cytological Location
Cytogenetic map Notes References 101F-102A   (determined by in situ hybridisation)   (Dubreuil and Yu, 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ank for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.46 Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ank-RB FBtr0089173  NM_175926   5101   1549 Ank-RC FBtr0089171  NM_175927   5176   1549 Ank-RD FBtr0089172  NM_175928   5291   1549 Ank-RE FBtr0300497  NM_001169348   5777   1549
Additional Transcript Data & Comments
Reported size (kB)	5.5 (northern blot) (Dubreuil and Yu, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ank-PB   FBpp0088240   170.2   1549   7.05     NP_787122   AAF59369 Ank-PC   FBpp0088238   170.2   1549   7.05     NP_787123   AAG22123 Ank-PD   FBpp0088239   170.2   1549   7.05     NP_787124   AAN06551 Ank-PE   FBpp0289724   170.2   1549   7.05     NP_001162819   ACZ95088
Additional Polypeptide Data & Comments
Reported size (kDa)	1549 (aa); 170 (kD observed); 170 (kD predicted) (Dubreuil and Yu, 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Death domain (IPR000488) ZU5 (IPR000906) Ankyrin repeat (IPR002110) Death-like domain (IPR011029) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392270   AA440923   AA540798   AA735654   AA735848   AA801889   AA941217   AE014135 AAF59369   AE014135 AAG22123   AE014135 AAN06551   AC011250   AE014135 ACZ95088   AI107365   AI294977   AI544049   AW942608   AY054998 AAL15156   AY058513 AAL13742   BI165534   BI171358   BI171765   BI213908   BI371773   BI482438   BI577953   BI583800   BI629032   BI629453   BP550740   BP550741   BP552176   BP552177   BT022086   BT031123   CA805338   CK661896   CO178526   CO182993   CO186933   CO187442   CO188644   CO191242   CO264083   CO266407   CO267557   CO269038   CO269520   CO269843   CO270932   CO275272   CO276353   CO277036   CO280955   CO282952   CO284179   CO284381   CO284966   CO285914   CO292453   CO294097   CO294288   CO295416   CO296115   CO299431   CO305096   CO307166   CO309381   CO309800   CO310501   CO312102   CO318254   CO318375   CO323997   CO324034   CO324193   CO329438   CO339948   CO340207   CO340727   CO340959   CO341096   CO342547   CO342808   EC061548   EC064693   EC069918   EC071398   EC073619   EC074683   EC075618   EC075688   EC080666   EC082608   EC087202   EC197738   EC199635   EC206362   EC206363   EC207246   EC211439   EC213251   EC220121   EC223756   EC227166   EC229529   EC231932   EC233670   EC234154   EC235584   EC236487   EC236980   EC239323   EC240722   EC241008   EC243058   EC243147   EC244896   EC245277   EC247166   EC247762   EC249396   EC250023   EC250078   EC256095   EC257026   EC258112   EC259330   EC259341   EV580017   EV583973   EV594691   GH757949   GH785433   GH806045   GH806578   GH834147   GH843802   GH844448   GH861563   GH880819   GH897797   GH901095   GH902496   GH915703   GH927979   GH929402   GH932000   GH938022   GH941636   GH943374   GH944373   GH945304   GH947835   GH949221   GH954713   GH956684   GH960022   GH960193   GH960940   GH961349   GH969526   GH970156   GH974549   GH974598   GH975120   GH976597   L35601 AAC37208
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q0KIE7 Q24241 Q95TU4 Q95UF0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Bouley et al., 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Dubreuil and Yu, 1994) embryonic stage -- adult stage   organism   (Bouley et al., 2000) oogenesis & adult stage | female   ovary   (Dubreuil and Yu, 1994)   S2 cell-line   (Bouley et al., 2000)
Additional Descriptive Data
	Ank transcripts are detected in RNA from ovaries and embryos. (Dubreuil and Yu, 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   salivary gland   • plasma membrane (Dubreuil et al., 1997) adult stage & oogenesis   follicle cell   (Dubreuil et al., 1997) adult stage & oogenesis | early   spectrosome of germline stem cell   (de Cuevas et al., 1996) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Bouley et al., 2000) embryonic stage 14   salivary gland body primordium   (Bouley et al., 2000) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   • membrane (Bouley et al., 2000) embryonic stage & larval stage & adult stage     (Dubreuil and Yu, 1994)
Additional Descriptive Data
	Ank protein is detected in embryos, larvae, adults and S2 cells. (Dubreuil et al., 1997, Dubreuil and Yu, 1994) Ank is expressed at the lateral cell contacts of follicle cells in the ovary. (Dubreuil et al., 1997)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
NOT fusome inferred from direct assay (de Cuevas et al., 1996) plasma membrane inferred from direct assay (Dubreuil et al., 1997, Das et al., 2006, Khanna et al., 2010) spectrosome inferred from direct assay (de Cuevas et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, adult heart, adult fat body, adult salivary gland, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    714.4 Larval Midgut    466.1 Larval Hindgut    688.6 Larval Malpighian Tubules    504.7 Larval Fat Body    684.7 Larval Salivary Gland    547 Larval Trachea    720.85 Larval Carcass    678.7 Adult Head    582.3 Adult Eye    641.075 Adult Brain    926.4 Adult Thoracic-Abdominal Ganglion    869.4 Adult Crop    730.7 Adult Midgut    330 Adult Hindgut    513.4 Adult Malpighian Tubules    575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca    775.6 Adult InseminatedFemale Spermatheca    735.1 Adult Ovary    687.4 Adult Testis    190.6 Adult Male Accessory Gland    587.6 Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (714.4) Larval Midgut    466.1 Larval Hindgut  (688.6) Larval Malpighian Tubules  504.7 Larval Fat Body  (684.7) Larval Salivary Gland  (547) Larval Trachea  (720.85) Larval Carcass  (678.7) Adult Head  (582.3) Adult Eye  (641.075) Adult Brain  (926.4) Adult Thoracic-Abdominal Ganglion  (869.4) Adult Crop  (730.7) Adult Midgut    330 Adult Hindgut  513.4 Adult Malpighian Tubules  (575.7) Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca  (775.6) Adult InseminatedFemale Spermatheca  (735.1) Adult Ovary  (687.4) Adult Testis    190.6 Adult Male Accessory Gland  (587.6) Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    714.4 Larval Midgut    466.1 Larval Hindgut    688.6 Larval Malpighian Tubules    504.7 Larval Fat Body    684.7 Larval Salivary Gland    547 Larval Trachea    720.85 Larval Carcass    678.7 Adult Head    582.3 Adult Eye    641.075 Adult Brain    926.4 Adult Thoracic-Abdominal Ganglion    869.4 Adult Crop    730.7 Adult Midgut    330 Adult Hindgut    513.4 Adult Malpighian Tubules    575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca    775.6 Adult InseminatedFemale Spermatheca    735.1 Adult Ovary    687.4 Adult Testis    190.6 Adult Male Accessory Gland    587.6 Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    714.4 Larval Midgut    466.1 Larval Hindgut    688.6 Larval Malpighian Tubules    504.7 Larval Fat Body    684.7 Larval Salivary Gland    547 Larval Trachea    720.85 Larval Carcass    678.7 Adult Head    582.3 Adult Eye    641.075 Adult Brain    926.4 Adult Thoracic-Abdominal Ganglion    869.4 Adult Crop    730.7 Adult Midgut    330 Adult Hindgut    513.4 Adult Malpighian Tubules    575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca    775.6 Adult InseminatedFemale Spermatheca    735.1 Adult Ovary    687.4 Adult Testis    190.6 Adult Male Accessory Gland    587.6 Adult Carcass    391.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    714.4 Larval Midgut    466.1 Larval Hindgut    688.6 Larval Malpighian Tubules    504.7 Larval Fat Body    684.7 Larval Salivary Gland    547 Larval Trachea    720.85 Larval Carcass    678.7 Adult Head    582.3 Adult Eye    641.075 Adult Brain    926.4 Adult Thoracic-Abdominal Ganglion    869.4 Adult Crop    730.7 Adult Midgut    330 Adult Hindgut    513.4 Adult Malpighian Tubules    575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca    775.6 Adult InseminatedFemale Spermatheca    735.1 Adult Ovary    687.4 Adult Testis    190.6 Adult Male Accessory Gland    587.6 Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  714.4 Larval Midgut    466.1 Larval Hindgut  688.6 Larval Malpighian Tubules  504.7 Larval Fat Body  684.7 Larval Salivary Gland  547 Larval Trachea  720.85 Larval Carcass  678.7 Adult Head  582.3 Adult Eye  641.075 Adult Brain  (926.4) Adult Thoracic-Abdominal Ganglion  (869.4) Adult Crop  730.7 Adult Midgut    330 Adult Hindgut  513.4 Adult Malpighian Tubules  575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca  775.6 Adult InseminatedFemale Spermatheca  735.1 Adult Ovary  687.4 Adult Testis    190.6 Adult Male Accessory Gland  587.6 Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    714.4 Larval Midgut    466.1 Larval Hindgut    688.6 Larval Malpighian Tubules    504.7 Larval Fat Body    684.7 Larval Salivary Gland    547 Larval Trachea    720.85 Larval Carcass    678.7 Adult Head    582.3 Adult Eye    641.075 Adult Brain    926.4 Adult Thoracic-Abdominal Ganglion    869.4 Adult Crop    730.7 Adult Midgut    330 Adult Hindgut    513.4 Adult Malpighian Tubules    575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca    775.6 Adult InseminatedFemale Spermatheca    735.1 Adult Ovary    687.4 Adult Testis    190.6 Adult Male Accessory Gland    587.6 Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    714.4 Larval Midgut    466.1 Larval Hindgut    688.6 Larval Malpighian Tubules    504.7 Larval Fat Body    684.7 Larval Salivary Gland    547 Larval Trachea    720.85 Larval Carcass    678.7 Adult Head    582.3 Adult Eye    641.075 Adult Brain    926.4 Adult Thoracic-Abdominal Ganglion    869.4 Adult Crop    730.7 Adult Midgut    330 Adult Hindgut    513.4 Adult Malpighian Tubules    575.7 Adult Fat Body    429.4 Adult Salivary Gland    451.3 Adult Heart    412.7 Adult VirginFemale Spermatheca    775.6 Adult InseminatedFemale Spermatheca    735.1 Adult Ovary    687.4 Adult Testis    190.6 Adult Male Accessory Gland    587.6 Adult Carcass    391.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    582.3   NA  Eye    641.075   NA  Brain    926.4   714.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    869.4   NA  Crop    730.7   466.1  Midgut    330   688.6  Hindgut    513.4   504.7  Malpighian Tubules    575.7   684.7  Fat Body    429.4   547  Salivary Gland    451.3   NA  Heart    412.7   720.85  Trachea    NA   NA  VirginFemale Spermatheca    775.6   NA  InseminatedFemale Spermatheca    735.1   NA  Ovary    687.4   NA  Testis    190.6   NA  Male Accessory Gland    587.6   678.7  Carcass    391.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    32 central nervous system, pupae P8    49 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male    37 head, mated 4-day male    38 head, mated 20-day male    41 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering    27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female    45 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3  (32) central nervous system, pupae P8  (49) head, virgin 1-day female  (28) head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male  (37) head, mated 4-day male  (38) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae  (33) digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering  (27) carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female  (45) ovary, mated 4-day female  (28) testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    32 central nervous system, pupae P8    49 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male    37 head, mated 4-day male    38 head, mated 20-day male    41 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering    27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female    45 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    32 central nervous system, pupae P8    49 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male    37 head, mated 4-day male    38 head, mated 20-day male    41 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering    27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female    45 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    32 central nervous system, pupae P8    49 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male    37 head, mated 4-day male    38 head, mated 20-day male    41 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering    27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female    45 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3  32 central nervous system, pupae P8  (49) head, virgin 1-day female  28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male  (37) head, mated 4-day male  (38) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae  (33) digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering  27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female  (45) ovary, mated 4-day female  28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    32 central nervous system, pupae P8    49 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male    37 head, mated 4-day male    38 head, mated 20-day male    41 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering    27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female    45 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    32 central nervous system, pupae P8    49 head, virgin 1-day female    28 head, virgin 4-day female    23 head, virgin 20-day female    21 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    18 head, mated 1-day male    37 head, mated 4-day male    38 head, mated 20-day male    41 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    13 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    10 fat body, white prepupae    20 fat body, pupae P8    16 carcass, larvae L3 wandering    27 carcass, 1-day adult    18 carcass, 4-day adult    16 carcass, 20-day adult    12 ovary, virgin 4-day female    45 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    50 embryo 10-12hr    32 embryo 12-14hr    67 embryo 14-16hr    31 embryo 16-18hr    50 embryo 18-20hr    34 embryo 20-22hr    45 embryo 22-24hr    64 larva L1    28 larva L2    27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    57 white prepupae new    56 white prepupae 12hr    50 white prepupae 24hr    49 pupae 2d postWPP    48 pupae 3d postWPP    50 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day    40 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (49) embryo 04-06hr  (48) embryo 06-08hr  (37) embryo 08-10hr  (50) embryo 10-12hr  (32) embryo 12-14hr  (67) embryo 14-16hr  (31) embryo 16-18hr  (50) embryo 18-20hr  (34) embryo 20-22hr  (45) embryo 22-24hr  (64) larva L1  (28) larva L2  (27) larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  (38) larva L3 puffstage 7-9  (57) white prepupae new  (56) white prepupae 12hr  (50) white prepupae 24hr  (49) pupae 2d postWPP  (48) pupae 3d postWPP  (50) pupae 4d postWPP    20 adult male 01day  (31) adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day  (40) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    50 embryo 10-12hr    32 embryo 12-14hr    67 embryo 14-16hr    31 embryo 16-18hr    50 embryo 18-20hr    34 embryo 20-22hr    45 embryo 22-24hr    64 larva L1    28 larva L2    27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    57 white prepupae new    56 white prepupae 12hr    50 white prepupae 24hr    49 pupae 2d postWPP    48 pupae 3d postWPP    50 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day    40 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    50 embryo 10-12hr    32 embryo 12-14hr    67 embryo 14-16hr    31 embryo 16-18hr    50 embryo 18-20hr    34 embryo 20-22hr    45 embryo 22-24hr    64 larva L1    28 larva L2    27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    57 white prepupae new    56 white prepupae 12hr    50 white prepupae 24hr    49 pupae 2d postWPP    48 pupae 3d postWPP    50 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day    40 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    50 embryo 10-12hr    32 embryo 12-14hr    67 embryo 14-16hr    31 embryo 16-18hr    50 embryo 18-20hr    34 embryo 20-22hr    45 embryo 22-24hr    64 larva L1    28 larva L2    27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    57 white prepupae new    56 white prepupae 12hr    50 white prepupae 24hr    49 pupae 2d postWPP    48 pupae 3d postWPP    50 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day    40 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (49) embryo 04-06hr  (48) embryo 06-08hr  (37) embryo 08-10hr  (50) embryo 10-12hr  32 embryo 12-14hr  (67) embryo 14-16hr  31 embryo 16-18hr  (50) embryo 18-20hr  (34) embryo 20-22hr  (45) embryo 22-24hr  (64) larva L1  28 larva L2  27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  (38) larva L3 puffstage 7-9  (57) white prepupae new  (56) white prepupae 12hr  (50) white prepupae 24hr  (49) pupae 2d postWPP  (48) pupae 3d postWPP  (50) pupae 4d postWPP    20 adult male 01day  31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day  (40) adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    50 embryo 10-12hr    32 embryo 12-14hr    67 embryo 14-16hr    31 embryo 16-18hr    50 embryo 18-20hr    34 embryo 20-22hr    45 embryo 22-24hr    64 larva L1    28 larva L2    27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    57 white prepupae new    56 white prepupae 12hr    50 white prepupae 24hr    49 pupae 2d postWPP    48 pupae 3d postWPP    50 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day    40 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    49 embryo 04-06hr    48 embryo 06-08hr    37 embryo 08-10hr    50 embryo 10-12hr    32 embryo 12-14hr    67 embryo 14-16hr    31 embryo 16-18hr    50 embryo 18-20hr    34 embryo 20-22hr    45 embryo 22-24hr    64 larva L1    28 larva L2    27 larva L3 12hr old    22 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    57 white prepupae new    56 white prepupae 12hr    50 white prepupae 24hr    49 pupae 2d postWPP    48 pupae 3d postWPP    50 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    24 adult male 30day    18 adult female 01day    21 adult female 05day    40 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H    33 embryonic GM2    103 embryonic Kc167    23 embryonic S1    26 embryonic S3    35 leg disc CME L1    11 wing disc CME-W2    65 wing disc ML-DmD8    74 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    6 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    41 ovary fGS/OSS    22 ovary OSC    32 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H  (33) embryonic GM2  (103) embryonic Kc167    23 embryonic S1  26 embryonic S3  (35) leg disc CME L1    11 wing disc CME-W2  (65) wing disc ML-DmD8  (74) wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (37) wing disc ML-DmD21    6 wing disc ML-DmD32  (36) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2  (41) ovary fGS/OSS    22 ovary OSC  (32) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H    33 embryonic GM2  103 embryonic Kc167    23 embryonic S1    26 embryonic S3    35 leg disc CME L1    11 wing disc CME-W2    65 wing disc ML-DmD8    74 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    6 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    41 ovary fGS/OSS    22 ovary OSC    32 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H    33 embryonic GM2    103 embryonic Kc167    23 embryonic S1    26 embryonic S3    35 leg disc CME L1    11 wing disc CME-W2    65 wing disc ML-DmD8    74 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    6 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    41 ovary fGS/OSS    22 ovary OSC    32 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H    33 embryonic GM2    103 embryonic Kc167    23 embryonic S1    26 embryonic S3    35 leg disc CME L1    11 wing disc CME-W2    65 wing disc ML-DmD8    74 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    6 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    41 ovary fGS/OSS    22 ovary OSC    32 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H  (33) embryonic GM2  (103) embryonic Kc167    23 embryonic S1  26 embryonic S3  (35) leg disc CME L1    11 wing disc CME-W2  (65) wing disc ML-DmD8  (74) wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (37) wing disc ML-DmD21    6 wing disc ML-DmD32  (36) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2  (41) ovary fGS/OSS    22 ovary OSC  32 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H    33 embryonic GM2  103 embryonic Kc167    23 embryonic S1    26 embryonic S3    35 leg disc CME L1    11 wing disc CME-W2    65 wing disc ML-DmD8    74 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    6 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    41 ovary fGS/OSS    22 ovary OSC    32 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    12 embryonic 1182-4H    33 embryonic GM2    103 embryonic Kc167    23 embryonic S1    26 embryonic S3    35 leg disc CME L1    11 wing disc CME-W2    65 wing disc ML-DmD8    74 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    6 wing disc ML-DmD32    36 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    41 ovary fGS/OSS    22 ovary OSC    32 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (28) Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3  (30) Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (32) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (28) Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3  30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3  32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    23 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011747 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1651-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 AnkGD10431 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Ank Class Mutagen Stocks Known lesion AnkMB02705 1 -- AnkMB01701 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ank Class Mutagen Stocks Known lesion AnkGD10431 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AnkJF01588 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AnkdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes AnkRpS27A.T:Hsap\MYC,T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes AnkRpS27A.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes AnkScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10431} NA P{TRiP.JF01588} NA P{UAS-Ank.dsRNA} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}AnkMB01701 No Mi{ET1}AnkMB02705 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytoskeletal anchoring at plasma membrane inferred from direct assay (Dubreuil et al., 1997)
Cellular Component
CV term Evidence References
NOT fusome inferred from direct assay (de Cuevas et al., 1996) plasma membrane inferred from direct assay (Dubreuil et al., 1997, Das et al., 2006, Khanna et al., 2010) spectrosome inferred from direct assay (de Cuevas et al., 1996)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
cytoskeletal protein binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural constituent of cytoskeleton inferred from sequence or structural similarity with EMBL:X56958 (FlyBase, 1992-)
Biological Process
CV term Evidence References
signal transduction inferred from electronic annotation with InterPro:IPR000488 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
fusome non-traceable author statement (Deng and Lin, 2001) spectrosome traceable author statement (Deng and Lin, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ank - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ank - CG13630 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ank - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ank - CG9467 experimental knowledge based (Guruharsha et al., 2011) Ank - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ank - Odc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ank - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) Ank - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ank allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68608 DroID - A comprehensive database of gene and protein interactions. • FBgn0011747 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43770 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KIE7
Orthologs
OrthoDB Orthologs (69) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67H688 Dipteran inclusive ortholog search EOG683DCH Insect inclusive ortholog search EOG6B5N0Z Arthropod inclusive ortholog search EOG6C5B0C Metazoa inclusive ortholog search EOG6R5BVJ
Orthologs in Drosophila Species (EOG67H688)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ank     Drosophila sechellia   Dsec\GM23234 Y   Drosophila erecta   Dere\GG16463 Y   Drosophila yakuba   Dyak\GE14529 Y   Drosophila ananassae   Dana\GF23392 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14074 Y   Drosophila persimilis   Dper\GL18390 Y   Drosophila willistoni   Dwil\GK13612     Drosophila virilis   Dvir\GJ19213     Drosophila grimshawi   Dgri\GH23945 Y
Orthologs in non-Drosophila Dipterans (EOG683DCH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011565 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014668 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013466 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014742 Y Anopheles gambiae Malaria mosquito  Agam\AGAP009937 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002272 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017156 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010503 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002592 Y
Orthologs in non-Dipteran Insects (EOG6B5N0Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44218 Y Apis mellifera Western honey bee  Amel\GB46564 Y Apis mellifera Western honey bee  Amel\GB47425 Y Apis mellifera Western honey bee  Amel\GB45715 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010051 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011990 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15861 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21619 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17403 Y Atta cephalotes Leafcutter ant  Acep\ACEP11003 Y Atta cephalotes Leafcutter ant  Acep\ACEP16179 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14623 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18535 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13195 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10487 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26919 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11243 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL11614 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19388 Y Linepithema humile Argentine ant  Lhum\LH17900 Y Linepithema humile Argentine ant  Lhum\LH17830 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24205 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25065 Y Solenopsis invicta Red fire ant  Sinv\SINV15011 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI38268 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000387 Y Pediculus humanus Human body louse  Phum\PHUM596790 Y Pediculus humanus Human body louse  Phum\PHUM570540 Y Tribolium castaneum Red flour beetle  Tcas\TC003843 Y Tribolium castaneum Red flour beetle  Tcas\TC003960 Y
Orthologs in non-Insect Arthropods (EOG6C5B0C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\PHYP Y Daphnia pulex Water flea  Dpux\CYB561D1 Y Daphnia pulex Water flea  Dpux\COII Y Ixodes scapularis Deer tick  Isca\ISCW018406 Y
Orthologs in non-Arthropod Metazoa (EOG6R5BVJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\clx-1 Y Caenorhabditis elegans Nematode  Cele\unc-44 Y Caenorhabditis elegans Nematode  Cele\K02E11.10 Y Caenorhabditis elegans Nematode  Cele\K06A9.1 Y Caenorhabditis elegans Nematode  Cele\col-50 Y Caenorhabditis elegans Nematode  Cele\F16B4.4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000908gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021014gn Y Danio rerio Zebrafish  Drer\si:ch211-173b16.3 Y Danio rerio Zebrafish  Drer\OTTDARG00000031570 Y Danio rerio Zebrafish  Drer\CR388002.1 Y Xenopus tropicalis Western clawed frog  Xtro\ank1 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000003594 Y Mus musculus House mouse  Mmus\ENSMUSG00000031543 Y Rattus norvegicus Norway rat  Rnor\Ank1 Y Homo sapiens Human  Hsap\ANK1 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\ANK1
AAA Orthologs (7) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM23234 Drosophila erecta Dere\GG16463 Drosophila yakuba Dyak\GE14529 Drosophila ananassae Dana\GF23392 Drosophila pseudoobscura pseudoobscura Dpse\GA14074 Drosophila persimilis Dper\GL18390 Drosophila grimshawi Dgri\GH23945
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	25213 y1; Mi{ET1}AnkMB02705 31115 y1 v1; P{TRiP.JF01588}attP2/TM3, Sb1
VDRC	v25945 w1118; P{GD10431}v25945 v25946 w1118; P{GD10431}v25946
Genomic Clones ( 2 )
	BACR05L22 BACR21B19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 153 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10053 LD21682 RE13111
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04175 GM03542 GM09965 LD11111 LD12731 LD20616 LD25236 LD46072 LP08475 LP21683 RE05453 RE13608 RE19547 RE58750 RE65133 RE71730 RH22489 RH57825 RH58325
Other clones	1545 35352 35557 38019 42031 45658 46425 47265 56309 64773 65536 71868 73781 79143 80237 80993 82686 83416 97252 99454 104491 148339 165281 166339 166829 214221.5 214275.6 214315.4 214541.6 CK01.22B.G2 CK01.26A.D6 CK01.34C.E4 CK01.37B.D6 CK01.49D.B6 CK01.71D.G4 CK01.78C.E6 CK01.122B.E9 CK01.124D.A2 CK01.125B.H9 CK01.127B.G10 CK01.132C.H2 CK01.141A.E4 Dmel_dig_018875_0700_1034 Dmel_dig_020716_0673_0600 Dmel_neb_012182_0645_2927 EC24394 EC30509 EC256095 EK024836 EK029350 EK041339 EK056944 EK061151 EK093417 EK094833 EK096102 EK101061 EK116950 EK120608 EK122722 EK137341 EK146259 EK150822 EK155548 EK161837 EK165433 EK165931 EK167740 EK175438 EK192217 EK192403 EK192941 EK200223 EK206008 EK206508 EK209804 EK212736 EK217455 EK219341 EK221851 EK227876 EK247401 EK253812 EK271157 EK271832 EK292836 EP09716 EP10215 EP11225 EP11634 EP11849 EP15109 EP15539 ESG0117d.B21_A05 FGM208H02 FGM217C06 RP003022562 RP003037708 RP003037709 RP003049794 RP003142725 RP003239165 RP003292773 RP003399743 RP003418801 RP003421783 RP003431619 RP003438458 RP003478370 RP003574065 RP003578402 RP003597072 RP003679019 RP004073737 RP004109447 RP004187296 RP004204910 RP004232557 RP004241650 RP004250639 RP004264295 RP004315961 RP004349447 RP004360490 RP004361243 RP004430953 RP004440005 RP004536245 RP004539244 RP004547789 RP004549730
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011747 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43770
Antibody Information
	polyclonal (Dubreuil and Yu, 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ank CG1651 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Ank is not required for the recruitment of Spectrin to postsynaptic muscle membranes at the neuromuscular junction. (Pielage et al., 2006) Ank contributes to the Spectrin-dependent control of synapse development. (Pielage et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The molecular evolution of the Rel/NF-κB and IκB proteins is studied in parallel. Phylogenetic analysis allows the structure of the putative ancestor genes to be defined and proposes and evolutionary model that clusters both families in a unique Rel/NF-κB/IκB superfamily. (Huguet et al., 1997) Elimination of α-Spec from follicle cells does not appear to prevent the assembly of conventional β-Spec and Ank products at the lateral domain of the follicle cell plasma membrane. (Lee et al., 1997) The Ank gene product is a component of spectrosomes but not fusomes. (de Cuevas et al., 1996) Interaction between Ank and Nrg molecules occurs by a mechanism that couples the positional information of cell adhesion to the polar assembly of Ank. (Dubreuil et al., 1996) Ank was identified by amplification of genomic DNA with oligonucleotide primers based on a conserved region of mammalian brain ankyrin. (Dubreuil and Yu, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_175926 NM_175927 NM_175928 NM_001169348 RefSeq (Proteins) • NP_787122 NP_787123 NP_787124 NP_001162819 DDBJ / EMBL / GenBank • AA735654 AAC37208 AAF59369 AAG22123 AAL13742 AAL15156 AAN06550 AAN06551 AC011250 ACZ95088 ACZ95089 AW942608 AY054998 AY058513 BI171358 L35601 Entrez Gene - A searchable database of RefSeq genes. • 43770 UniProtKB/TrEMBL • Q0KIE7 Q95TU4 Q95UF0 Q24241
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Death domain (IPR000488) ZU5 (IPR000906) Ankyrin repeat (IPR002110) Death-like domain (IPR011029) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68608 DroID - A comprehensive database of gene and protein interactions. • FBgn0011747 DRSC - Results from RNAi screens. • FBgn0011747 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011747 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1651-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011747 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43770 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43770 modMine - Data generated by the modENCODE project. • FBgn0011747 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KIE7
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	ank (Jasper et al., 2002, Pielage et al., 2006) ANK (Khush and Lemaitre, 2000, Pebusque et al., 1998) Ank (Masly et al., 2006, Stuart et al., 2007, Bakal et al., 2007, Johansson et al., 2007, Deng et al., 2009, Spresser et al., 2008, Curtis et al., 2007) CG1651 (Ryder et al., 2004, Jensen, 2001.4.18, Goldstein and Gunawardena, 2000, Khanna et al., 2010, Ni et al., 2008, Cammarato et al., 2011) CG32008   Dank1 (Bouley et al., 2000) dank1 (Garbe et al., 2007) DAnk1 (Mazock et al., 2010)
Name Synonym	ankyrin (Das et al., 2006, Deng and Lin, 2001, Dubreuil, 1994.10.25, Dubreuil et al., 1997, Bakal et al., 2007, Yamashita et al., 2005, Mudiganti et al., 2010, Kohsaka et al., 2007, Mazock et al., 2010) Ankyrin (Pielage et al., 2006, Khanna et al., 2010, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 86 )
Generate a list of	All references relating to this gene ( 86 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 12 ) Review  ( 11 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 3 )
Recent research papers (0)
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Recent reviews (0)
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