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Gene Dmel\ctp

General Information
Symbol	Dmel\ctp	Species	D. melanogaster
Name	cut up	Annotation symbol	CG6998
Feature type	protein_coding_gene	FlyBase ID	FBgn0011760
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	ddlc1, LC8, Ddlc-1, dlc, Cdlc1
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	4C13-4C14	Sequence location	X:4,581,833..4,596,067 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cut up is referred to in FlyBase by the symbol Dmel\ctp (CG6998, FBgn0011760). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: dynein intermediate chain binding; protein binding; protein homodimerization activity. There is experimental evidence for 14 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; multicellular organism reproduction; system development; sensory organ development; spermatid differentiation; gamete generation; organelle organization; localization; gland morphogenesis; post-embryonic organ morphogenesis; catabolic process. 56 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organ system subdivision; sense organ; eo support cell; anatomical structure; adult segment; cell cluster organ; spermatozoon; cytoplasmic part. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Dynein light chain, type 1/2; Dynein light chain, type 1/2, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Gene sequence location is X:4581833..4596067.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4C13-4C14   Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
Experimentally Determined Cytological Location
Cytogenetic map Notes References 4C15-4D2   (determined by in situ hybridisation) 4C5--8 (determined by in situ hybridisation) 4C7--8 (determined by in situ hybridisation) 4D1--2 (determined by in situ hybridisation) 4C13--16 (determined by in situ hybridisation) 4C11--14 (determined by in situ hybridisation) 4C15--CD3 (determined by in situ hybridisation)   (Peter et al., 2002) 4C7-4C8   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 4D-4D     (Li, 1996.2.9) 4E1-4E2     (Dick, 1995.8.1) 4C15-4D3   (determined by in situ hybridisation) 4D1--2 (determined by in situ hybridisation) 4C5--8 (determined by in situ hybridisation) 4C15--D2 (determined by in situ hybridisation) 4D1--2 (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 4C11-4C14   (determined by in situ hybridisation) 4C13--16 (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 4D1-4D3   (determined by in situ hybridisation)   (Phillis et al., 1996) 4E1-4E2   (determined by in situ hybridisation)   (Dick et al., 1996) 4D-4D   (determined by in situ hybridisation)   (Gramates and Phillis, 1995)
Experimentally Determined Recombination Data
Location	1- (Dick, 1995.8.1)
Left of (cM)	ct (Phillis et al., 1994)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ctp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Candidate for stop_codon_read_through: transcripts of this gene may undergo stop-codon suppression and translation read-through (FBrf0216884). Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ctp-RA FBtr0070706  NM_080336   1483   89 ctp-RB FBtr0070704  NM_167014   1597   89 ctp-RC FBtr0070707  NM_167015   2267   89 ctp-RD FBtr0070705  NM_167016   1457   89 ctp-RE FBtr0307065  NM_001258601   4061   89
Additional Transcript Data & Comments
Reported size (kB)	4.5, 2.4 (northern blot) (Dick et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ctp-PA   FBpp0070674   10.4   89   7.50     NP_525075   AAF45975 ctp-PB   FBpp0070672   10.4   89   7.50     NP_726942   AAN09126 ctp-PC   FBpp0070675   10.4   89   7.50     NP_726943   AAN09127 ctp-PD   FBpp0070673   10.4   89   7.50     NP_726944   AAN09128 ctp-PE   FBpp0297908   10.4   89   7.50     NP_001245530   AFH07244
Additional Polypeptide Data & Comments
Reported size (kDa)	89 (aa); 10 (kD predicted) (Dick et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dynein light chain, type 1/2 (IPR001372) Dynein light chain, type 1/2, conserved site (IPR019763)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201563   AA263835   AA263959   AA391327   AA392231   AA392261   AA440053   AA440510   AA735238   AA802175   AA820434   AA821093   AA948807   AA949175   AA978560   AA979427   AE014298 AAF45975   AE014298 AAN09126   AE014298 AAN09127   AE014298 AAN09128   AE014298 AFH07244   AI109315   AI238641   AI257308   AI260785   AI260824   AI292550   AI293363   AI387858   AI389488   AI389839   AI403372   AI403469   AI405765   AI512087   AI512810   AI516163   AI518701   AI543711   AI945386   AI946354   AJ426676   AJ426678   AJ426679   AJ426683   AJ426684   AJ426685   AJ426686   AJ426687   AX777274   AY094798 AAM11151   AY232086   BF489003   BG632235   BG632347   BG633413   BG633495   BG635226   BG639355   BG639371   BG641463   BH011447   BI161702   BI161703   BI163360   BI163895   BI164259   BI166013   BI166242   BI167026   BI167426   BI167539   BI170506   BI172772   BI173029   BI173107   BI173306   BI173490   BI173746   BI173964   BI212748   BI215891   BI215957   BI228825   BI229077   BI229178   BI231296   BI231887   BI232911   BI233048   BI234063   BI234143   BI235697   BI237956   BI240081   BI241270   BI241820   BI243122   BI352656   BI355418   BI355565   BI356162   BI356262   BI357115   BI357913   BI361957   BI362327   BI362478   BI364805   BI365177   BI366659   BI367215   BI367746   BI368509   BI368779   BI369070   BI370468   BI370959   BI371145   BI372125   BI372605   BI372827   BI373381   BI375001   BI375412   BI482425   BI482866   BI483012   BI484676   BI564701   BI577601   BI578845   BI579126   BI579448   BI580511   BI580721   BI581882   BI593518   BI614140   BI620281   BI620445   BI635213   BI635893   BI640317   BP541179   BP541180   BP543031   BP543032   BP543994   BP546016   BP546486   BP548025   BP548546   BP553563   BP553564   BP557941   BP557942   CK445265   CK662020   CO154245   CO177267   CO188481   CO188822   CO188867   CO189587   CO189841   CO195020   CO196146   CO264045   CO266944   CO267278   CO268888   CO269640   CO270887   CO271925   CO272715   CO274747   CO275123   CO277640   CO279720   CO280347   CO280535   CO283258   CO284949   CO285065   CO285810   CO285832   CO285871   CO286077   CO287892   CO288583   CO288912   CO289326   CO289552   CO289877   CO290235   CO290797   CO290882   CO291583   CO292326   CO292587   CO294883   CO295299   CO295571   CO296536   CO296904   CO297094   CO299110   CO303408   CO303548   CO305575   CO307812   CO307871   CO308121   CO308176   CO308645   CO316091   CO316680   CO317233   CO317830   CO319581   CO320413   CO320870   CO320898   CO321905   CO325131   CO330619   CO332186   CO333017   CO335860   CZ474730   EC056970   EC057788   EC063008   EC063504   EC067014   EC067203   EC067452   EC068196   EC069297   EC069390   EC069931   EC070426   EC070981   EC072141   EC073090   EC075092   EC076490   EC079327   EC080099   EC080783   EC081624   EC082338   EC082339   EC082405   EC083691   EC086949   EC088559   EC090045   EC194719   EC195379   EC197255   EC197830   EC200374   EC201484   EC204782   EC205255   EC205590   EC205606   EC207369   EC207782   EC214505   EC215775   EC216285   EC218172   EC218745   EC219170   EC219273   EC220981   EC221832   EC222228   EC222471   EC224599   EC226316   EC226916   EC227067   EC228756   EC230545   EC230555   EC230790   EC231469   EC231481   EC232366   EC233564   EC235545   EC236143   EC239275   EC241060   EC241529   EC241810   EC243024   EC244227   EC245347   EC246841   EC247633   EC248687   EC249480   EC249528   EC249534   EC250282   EC265945   EC267638   EL872619   EL882222   EL882223   EL887480   EV577413   EV580736   EV583661   EV590574   EV591216   EV594979   EV597339   GH747816   GH748663   GH749622   GH750815   GH751295   GH752870   GH756894   GH758575   GH759131   GH760046   GH760497   GH773067   GH774230   GH779516   GH781141   GH781545   GH782332   GH782928   GH783223   GH783532   GH785336   GH785551   GH788677   GH791840   GH792523   GH795413   GH797773   GH798179   GH798205   GH798653   GH799151   GH800272   GH800299   GH801823   GH806321   GH807410   GH809317   GH813681   GH814088   GH816047   GH823976   GH824434   GH829686   GH833570   GH833987   GH834199   GH836187   GH839635   GH844641   GH846196   GH849175   GH850334   GH851332   GH855093   GH855975   GH856059   GH856924   GH858559   GH860270   GH861455   GH865426   GH868721   GH869396   GH869450   GH873275   GH873629   GH874479   GH874698   GH876392   GH876741   GH879791   GH879799   GH882833   GH882874   GH882971   GH883908   GH886516   GH886555   GH891321   GH891723   GH893465   GH896556   GH897808   GH898857   GH903648   GH906718   GH906854   GH907544   GH908750   GH908984   GH909697   GH909761   GH910695   GH912219   GH912240   GH912925   GH915881   GH918777   GH918865   GH920309   GH921133   GH922072   GH925503   GH927085   GH929243   GH931678   GH934065   GH934185   GH934593   GH935175   GH935688   GH935868   GH935977   GH936614   GH937397   GH937565   GH938501   GH939718   GH939900   U32855 AAB04148   U48846 AAD00072   U48848
UniProtKB/Swiss-Prot	Q24117
UniProtKB/TrEMBL	Q8SX77
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage hindgut anlage   (Fisher et al., 2012) organism | intense & ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium inclusive hindgut primordium   (Fisher et al., 2012) organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) organism | intense & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Dick et al., 1996) embryonic stage | late   chordotonal organ   (Dick et al., 1996)   (Dick et al., 1996) presumptive embryonic/larval central nervous system   (Dick et al., 1996) embryonic stage -- adult stage     (Dick et al., 1996) pupal stage     (Dick et al., 1996) adult stage   head   (Dick et al., 1996) adult stage & oogenesis   nurse cell   (Dick et al., 1996) adult stageoogenesis stage S11 -- S14   oocyte   (Dick et al., 1996)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Dick et al., 1996) oogenesis   organism | ubiquitous   (Dick et al., 1996) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	ctp protein is localized in the cytoplasm where it is associated with microtubules. (Dick et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centriole inferred from direct assay (Wang et al., 2011) cytoplasm inferred from direct assay (assigned by UniProtKB) (Dick et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    255 central nervous system, larvae L3    620 central nervous system, pupae P8    517 head, virgin 1-day female    431 head, virgin 4-day female    329 head, virgin 20-day female    88 head, mated 1-day female    524 head, mated 4-day female    322 head, mated 20-day female    112 head, mated 1-day male    513 head, mated 4-day male    514 head, mated 20-day male    326 salivary gland, larvae L3 wandering    118 salivary gland, white prepupae    93 digestive system, larvae L3 wandering    186 digestive system, 1-day adult    135 digestive system, 4-day adult    202 digestive system, 20-day adult    108 fat body, larvae L3 wandering    224 fat body, white prepupae    145 fat body, pupae P8    217 carcass, larvae L3 wandering    330 carcass, 1-day adult    193 carcass, 4-day adult    214 carcass, 20-day adult    141 ovary, virgin 4-day female    217 ovary, mated 4-day female    636 testis, mated 4-day male    85 accessory gland, mated 4-day male    115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (255) central nervous system, larvae L3  (620) central nervous system, pupae P8  (517) head, virgin 1-day female  (431) head, virgin 4-day female  (329) head, virgin 20-day female  (88) head, mated 1-day female  (524) head, mated 4-day female  (322) head, mated 20-day female  (112) head, mated 1-day male  (513) head, mated 4-day male  (514) head, mated 20-day male  (326) salivary gland, larvae L3 wandering  (118) salivary gland, white prepupae  (93) digestive system, larvae L3 wandering  (186) digestive system, 1-day adult  (135) digestive system, 4-day adult  (202) digestive system, 20-day adult  (108) fat body, larvae L3 wandering  (224) fat body, white prepupae  (145) fat body, pupae P8  (217) carcass, larvae L3 wandering  (330) carcass, 1-day adult  (193) carcass, 4-day adult  (214) carcass, 20-day adult  (141) ovary, virgin 4-day female  (217) ovary, mated 4-day female  (636) testis, mated 4-day male  (85) accessory gland, mated 4-day male  (115) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (255) central nervous system, larvae L3  (620) central nervous system, pupae P8  (517) head, virgin 1-day female  (431) head, virgin 4-day female  (329) head, virgin 20-day female    88 head, mated 1-day female  (524) head, mated 4-day female  (322) head, mated 20-day female  (112) head, mated 1-day male  (513) head, mated 4-day male  (514) head, mated 20-day male  (326) salivary gland, larvae L3 wandering  (118) salivary gland, white prepupae    93 digestive system, larvae L3 wandering  (186) digestive system, 1-day adult  (135) digestive system, 4-day adult  (202) digestive system, 20-day adult  (108) fat body, larvae L3 wandering  (224) fat body, white prepupae  (145) fat body, pupae P8  (217) carcass, larvae L3 wandering  (330) carcass, 1-day adult  (193) carcass, 4-day adult  (214) carcass, 20-day adult  (141) ovary, virgin 4-day female  (217) ovary, mated 4-day female  (636) testis, mated 4-day male    85 accessory gland, mated 4-day male  (115) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    255 central nervous system, larvae L3    620 central nervous system, pupae P8    517 head, virgin 1-day female    431 head, virgin 4-day female    329 head, virgin 20-day female    88 head, mated 1-day female    524 head, mated 4-day female    322 head, mated 20-day female    112 head, mated 1-day male    513 head, mated 4-day male    514 head, mated 20-day male    326 salivary gland, larvae L3 wandering    118 salivary gland, white prepupae    93 digestive system, larvae L3 wandering    186 digestive system, 1-day adult    135 digestive system, 4-day adult    202 digestive system, 20-day adult    108 fat body, larvae L3 wandering    224 fat body, white prepupae    145 fat body, pupae P8    217 carcass, larvae L3 wandering    330 carcass, 1-day adult    193 carcass, 4-day adult    214 carcass, 20-day adult    141 ovary, virgin 4-day female    217 ovary, mated 4-day female    636 testis, mated 4-day male    85 accessory gland, mated 4-day male    115 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    255 central nervous system, larvae L3    620 central nervous system, pupae P8    517 head, virgin 1-day female    431 head, virgin 4-day female    329 head, virgin 20-day female    88 head, mated 1-day female    524 head, mated 4-day female    322 head, mated 20-day female    112 head, mated 1-day male    513 head, mated 4-day male    514 head, mated 20-day male    326 salivary gland, larvae L3 wandering    118 salivary gland, white prepupae    93 digestive system, larvae L3 wandering    186 digestive system, 1-day adult    135 digestive system, 4-day adult    202 digestive system, 20-day adult    108 fat body, larvae L3 wandering    224 fat body, white prepupae    145 fat body, pupae P8    217 carcass, larvae L3 wandering    330 carcass, 1-day adult    193 carcass, 4-day adult    214 carcass, 20-day adult    141 ovary, virgin 4-day female    217 ovary, mated 4-day female    636 testis, mated 4-day male    85 accessory gland, mated 4-day male    115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (255) central nervous system, larvae L3  (620) central nervous system, pupae P8  (517) head, virgin 1-day female  (431) head, virgin 4-day female  (329) head, virgin 20-day female  (88) head, mated 1-day female  (524) head, mated 4-day female  (322) head, mated 20-day female  (112) head, mated 1-day male  (513) head, mated 4-day male  (514) head, mated 20-day male  (326) salivary gland, larvae L3 wandering  (118) salivary gland, white prepupae  (93) digestive system, larvae L3 wandering  (186) digestive system, 1-day adult  (135) digestive system, 4-day adult  (202) digestive system, 20-day adult  (108) fat body, larvae L3 wandering  (224) fat body, white prepupae  (145) fat body, pupae P8  (217) carcass, larvae L3 wandering  (330) carcass, 1-day adult  (193) carcass, 4-day adult  (214) carcass, 20-day adult  (141) ovary, virgin 4-day female  (217) ovary, mated 4-day female  (636) testis, mated 4-day male  (85) accessory gland, mated 4-day male  (115) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (255) central nervous system, larvae L3  (620) central nervous system, pupae P8  (517) head, virgin 1-day female  (431) head, virgin 4-day female  (329) head, virgin 20-day female    88 head, mated 1-day female  (524) head, mated 4-day female  (322) head, mated 20-day female  112 head, mated 1-day male  (513) head, mated 4-day male  (514) head, mated 20-day male  (326) salivary gland, larvae L3 wandering  118 salivary gland, white prepupae    93 digestive system, larvae L3 wandering  (186) digestive system, 1-day adult  135 digestive system, 4-day adult  (202) digestive system, 20-day adult  108 fat body, larvae L3 wandering  (224) fat body, white prepupae  (145) fat body, pupae P8  (217) carcass, larvae L3 wandering  (330) carcass, 1-day adult  (193) carcass, 4-day adult  (214) carcass, 20-day adult  141 ovary, virgin 4-day female  (217) ovary, mated 4-day female  (636) testis, mated 4-day male    85 accessory gland, mated 4-day male  115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    255 central nervous system, larvae L3    620 central nervous system, pupae P8    517 head, virgin 1-day female    431 head, virgin 4-day female    329 head, virgin 20-day female    88 head, mated 1-day female    524 head, mated 4-day female    322 head, mated 20-day female    112 head, mated 1-day male    513 head, mated 4-day male    514 head, mated 20-day male    326 salivary gland, larvae L3 wandering    118 salivary gland, white prepupae    93 digestive system, larvae L3 wandering    186 digestive system, 1-day adult    135 digestive system, 4-day adult    202 digestive system, 20-day adult    108 fat body, larvae L3 wandering    224 fat body, white prepupae    145 fat body, pupae P8    217 carcass, larvae L3 wandering    330 carcass, 1-day adult    193 carcass, 4-day adult    214 carcass, 20-day adult    141 ovary, virgin 4-day female    217 ovary, mated 4-day female    636 testis, mated 4-day male    85 accessory gland, mated 4-day male    115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    92 embryo 02-04hr    141 embryo 04-06hr    93 embryo 06-08hr    85 embryo 08-10hr    103 embryo 10-12hr    66 embryo 12-14hr    84 embryo 14-16hr    62 embryo 16-18hr    89 embryo 18-20hr    73 embryo 20-22hr    83 embryo 22-24hr    96 larva L1    68 larva L2    63 larva L3 12hr old    64 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    91 white prepupae new    86 white prepupae 12hr    77 white prepupae 24hr    93 pupae 2d postWPP    79 pupae 3d postWPP    79 pupae 4d postWPP    81 adult male 01day    53 adult male 05day    43 adult male 30day    43 adult female 01day    59 adult female 05day    74 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (92) embryo 02-04hr  (141) embryo 04-06hr  (93) embryo 06-08hr  (85) embryo 08-10hr  (103) embryo 10-12hr  (66) embryo 12-14hr  (84) embryo 14-16hr  (62) embryo 16-18hr  (89) embryo 18-20hr  (73) embryo 20-22hr  (83) embryo 22-24hr  (96) larva L1  (68) larva L2  (63) larva L3 12hr old  (64) larva L3 puffstage 1-2  (55) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9  (91) white prepupae new  (86) white prepupae 12hr  (77) white prepupae 24hr  (93) pupae 2d postWPP  (79) pupae 3d postWPP  (79) pupae 4d postWPP  (81) adult male 01day  (53) adult male 05day  (43) adult male 30day  (43) adult female 01day  (59) adult female 05day  (74) adult female 30day  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    92 embryo 02-04hr  (141) embryo 04-06hr    93 embryo 06-08hr    85 embryo 08-10hr  103 embryo 10-12hr    66 embryo 12-14hr    84 embryo 14-16hr    62 embryo 16-18hr    89 embryo 18-20hr    73 embryo 20-22hr    83 embryo 22-24hr    96 larva L1    68 larva L2    63 larva L3 12hr old    64 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    91 white prepupae new    86 white prepupae 12hr    77 white prepupae 24hr    93 pupae 2d postWPP    79 pupae 3d postWPP    79 pupae 4d postWPP    81 adult male 01day    53 adult male 05day    43 adult male 30day    43 adult female 01day    59 adult female 05day    74 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    92 embryo 02-04hr    141 embryo 04-06hr    93 embryo 06-08hr    85 embryo 08-10hr    103 embryo 10-12hr    66 embryo 12-14hr    84 embryo 14-16hr    62 embryo 16-18hr    89 embryo 18-20hr    73 embryo 20-22hr    83 embryo 22-24hr    96 larva L1    68 larva L2    63 larva L3 12hr old    64 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    91 white prepupae new    86 white prepupae 12hr    77 white prepupae 24hr    93 pupae 2d postWPP    79 pupae 3d postWPP    79 pupae 4d postWPP    81 adult male 01day    53 adult male 05day    43 adult male 30day    43 adult female 01day    59 adult female 05day    74 adult female 30day    71 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    92 embryo 02-04hr    141 embryo 04-06hr    93 embryo 06-08hr    85 embryo 08-10hr    103 embryo 10-12hr    66 embryo 12-14hr    84 embryo 14-16hr    62 embryo 16-18hr    89 embryo 18-20hr    73 embryo 20-22hr    83 embryo 22-24hr    96 larva L1    68 larva L2    63 larva L3 12hr old    64 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    91 white prepupae new    86 white prepupae 12hr    77 white prepupae 24hr    93 pupae 2d postWPP    79 pupae 3d postWPP    79 pupae 4d postWPP    81 adult male 01day    53 adult male 05day    43 adult male 30day    43 adult female 01day    59 adult female 05day    74 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (92) embryo 02-04hr  (141) embryo 04-06hr  (93) embryo 06-08hr  (85) embryo 08-10hr  (103) embryo 10-12hr  (66) embryo 12-14hr  (84) embryo 14-16hr  (62) embryo 16-18hr  (89) embryo 18-20hr  (73) embryo 20-22hr  (83) embryo 22-24hr  (96) larva L1  (68) larva L2  (63) larva L3 12hr old  (64) larva L3 puffstage 1-2  (55) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9  (91) white prepupae new  (86) white prepupae 12hr  (77) white prepupae 24hr  (93) pupae 2d postWPP  (79) pupae 3d postWPP  (79) pupae 4d postWPP  (81) adult male 01day  (53) adult male 05day  (43) adult male 30day  (43) adult female 01day  (59) adult female 05day  (74) adult female 30day  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    92 embryo 02-04hr  141 embryo 04-06hr    93 embryo 06-08hr    85 embryo 08-10hr  103 embryo 10-12hr    66 embryo 12-14hr    84 embryo 14-16hr    62 embryo 16-18hr    89 embryo 18-20hr    73 embryo 20-22hr    83 embryo 22-24hr    96 larva L1    68 larva L2    63 larva L3 12hr old    64 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    91 white prepupae new    86 white prepupae 12hr    77 white prepupae 24hr    93 pupae 2d postWPP    79 pupae 3d postWPP    79 pupae 4d postWPP    81 adult male 01day    53 adult male 05day    43 adult male 30day    43 adult female 01day    59 adult female 05day    74 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    92 embryo 02-04hr    141 embryo 04-06hr    93 embryo 06-08hr    85 embryo 08-10hr    103 embryo 10-12hr    66 embryo 12-14hr    84 embryo 14-16hr    62 embryo 16-18hr    89 embryo 18-20hr    73 embryo 20-22hr    83 embryo 22-24hr    96 larva L1    68 larva L2    63 larva L3 12hr old    64 larva L3 puffstage 1-2    55 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    91 white prepupae new    86 white prepupae 12hr    77 white prepupae 24hr    93 pupae 2d postWPP    79 pupae 3d postWPP    79 pupae 4d postWPP    81 adult male 01day    53 adult male 05day    43 adult male 30day    43 adult female 01day    59 adult female 05day    74 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    128 embryonic 1182-4H    281 embryonic GM2    189 embryonic Kc167    146 embryonic S1    284 embryonic S3    304 leg disc CME L1    355 wing disc CME-W2    183 wing disc ML-DmD8    254 wing disc ML-DmD9    457 wing disc ML-DmD16-c3    552 wing disc ML-DmD21    382 wing disc ML-DmD32    434 haltere disc ML-DmD17-c3    314 eye-antennal disc ML-DmD11    264 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    321 CNS ML-DmBG1-c1    582 CNS ML-DmBG2-c2    185 tumorous blood cells mbn2    260 ovary fGS/OSS    1179 ovary OSC    1196 ovary OSS    1257 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (128) embryonic 1182-4H  (281) embryonic GM2  (189) embryonic Kc167  (146) embryonic S1  (284) embryonic S3  (304) leg disc CME L1  (355) wing disc CME-W2  (183) wing disc ML-DmD8  (254) wing disc ML-DmD9  (457) wing disc ML-DmD16-c3  (552) wing disc ML-DmD21  (382) wing disc ML-DmD32  (434) haltere disc ML-DmD17-c3  (314) eye-antennal disc ML-DmD11  (264) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (321) CNS ML-DmBG1-c1  (582) CNS ML-DmBG2-c2  (185) tumorous blood cells mbn2  (260) ovary fGS/OSS  (1179) ovary OSC  (1196) ovary OSS  (1257) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (128) embryonic 1182-4H  (281) embryonic GM2  (189) embryonic Kc167  (146) embryonic S1  (284) embryonic S3  (304) leg disc CME L1  (355) wing disc CME-W2  (183) wing disc ML-DmD8  (254) wing disc ML-DmD9  (457) wing disc ML-DmD16-c3  (552) wing disc ML-DmD21  (382) wing disc ML-DmD32  (434) haltere disc ML-DmD17-c3  (314) eye-antennal disc ML-DmD11  (264) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (321) CNS ML-DmBG1-c1  (582) CNS ML-DmBG2-c2  (185) tumorous blood cells mbn2  (260) ovary fGS/OSS  (1179) ovary OSC  (1196) ovary OSS  (1257) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    128 embryonic 1182-4H    281 embryonic GM2    189 embryonic Kc167    146 embryonic S1    284 embryonic S3    304 leg disc CME L1    355 wing disc CME-W2    183 wing disc ML-DmD8    254 wing disc ML-DmD9    457 wing disc ML-DmD16-c3    552 wing disc ML-DmD21    382 wing disc ML-DmD32    434 haltere disc ML-DmD17-c3    314 eye-antennal disc ML-DmD11    264 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    321 CNS ML-DmBG1-c1    582 CNS ML-DmBG2-c2    185 tumorous blood cells mbn2    260 ovary fGS/OSS    1179 ovary OSC    1196 ovary OSS    1257 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    128 embryonic 1182-4H    281 embryonic GM2    189 embryonic Kc167    146 embryonic S1    284 embryonic S3    304 leg disc CME L1    355 wing disc CME-W2    183 wing disc ML-DmD8    254 wing disc ML-DmD9    457 wing disc ML-DmD16-c3    552 wing disc ML-DmD21    382 wing disc ML-DmD32    434 haltere disc ML-DmD17-c3    314 eye-antennal disc ML-DmD11    264 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    321 CNS ML-DmBG1-c1    582 CNS ML-DmBG2-c2    185 tumorous blood cells mbn2    260 ovary fGS/OSS    1179 ovary OSC    1196 ovary OSS    1257 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  (128) embryonic 1182-4H  (281) embryonic GM2  (189) embryonic Kc167  (146) embryonic S1  (284) embryonic S3  (304) leg disc CME L1  (355) wing disc CME-W2  (183) wing disc ML-DmD8  (254) wing disc ML-DmD9  (457) wing disc ML-DmD16-c3  (552) wing disc ML-DmD21  (382) wing disc ML-DmD32  (434) haltere disc ML-DmD17-c3  (314) eye-antennal disc ML-DmD11  (264) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (321) CNS ML-DmBG1-c1  (582) CNS ML-DmBG2-c2  (185) tumorous blood cells mbn2  (260) ovary fGS/OSS  (1179) ovary OSC  (1196) ovary OSS  (1257) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (400) Schneider line 2 Sg4  128 embryonic 1182-4H  (281) embryonic GM2  (189) embryonic Kc167  (146) embryonic S1  (284) embryonic S3  (304) leg disc CME L1  (355) wing disc CME-W2  (183) wing disc ML-DmD8  (254) wing disc ML-DmD9  (457) wing disc ML-DmD16-c3  (552) wing disc ML-DmD21  (382) wing disc ML-DmD32  (434) haltere disc ML-DmD17-c3  (314) eye-antennal disc ML-DmD11  (264) antennal disc ML-DmD20-c5  (189) mixed discs ML-DmD4-c1  (321) CNS ML-DmBG1-c1  (582) CNS ML-DmBG2-c2  (185) tumorous blood cells mbn2  (260) ovary fGS/OSS  (1179) ovary OSC  (1196) ovary OSS  (1257) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    400 Schneider line 2 Sg4    128 embryonic 1182-4H    281 embryonic GM2    189 embryonic Kc167    146 embryonic S1    284 embryonic S3    304 leg disc CME L1    355 wing disc CME-W2    183 wing disc ML-DmD8    254 wing disc ML-DmD9    457 wing disc ML-DmD16-c3    552 wing disc ML-DmD21    382 wing disc ML-DmD32    434 haltere disc ML-DmD17-c3    314 eye-antennal disc ML-DmD11    264 antennal disc ML-DmD20-c5    189 mixed discs ML-DmD4-c1    321 CNS ML-DmBG1-c1    582 CNS ML-DmBG2-c2    185 tumorous blood cells mbn2    260 ovary fGS/OSS    1179 ovary OSC    1196 ovary OSS    1257 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    619 cold shock, 4-day adult    484 heat shock, 4-day adult    268 Cadmium 50 mM 6 hrs, larvae L3    169 Cadmium 50 mM 12 hrs, larvae L3    201 Cadmium 50 mM 48 hrs, 4-day adult    310 Cadmium 100 mM 48 hrs, 4-day adult    476 Copper 0.5 mM 12 hrs, larvae L3    770 Copper 15 mM 48 hrs, 4-day adult    515 Zinc 5 mM 12 hrs, larvae L3    680 Zinc 4.5 mM 48 hrs, 4-day adult    564 Ethanol 2.5% 3 hrs, larvae L3    239 Ethanol 5% 3 hrs, larvae L3    161 Ethanol 10% 3 hrs, larvae L3    208 Caffeine 1.5 mg/ml 4 hrs, larvae L3    117 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    461 Caffeine 25 mg/ml 48 hrs, 4-day adult    709 Paraquat 5 mM 48 hrs, 4-day adult    358 Paraquat 10 mM 48 hrs, 4-day adult    229 Rotenone 2 μg 12 hrs, larvae L3    166 Rotenone 8 μg 12 hrs, larvae L3    122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (619) cold shock, 4-day adult  (484) heat shock, 4-day adult  (268) Cadmium 50 mM 6 hrs, larvae L3  (169) Cadmium 50 mM 12 hrs, larvae L3  (201) Cadmium 50 mM 48 hrs, 4-day adult  (310) Cadmium 100 mM 48 hrs, 4-day adult  (476) Copper 0.5 mM 12 hrs, larvae L3  (770) Copper 15 mM 48 hrs, 4-day adult  (515) Zinc 5 mM 12 hrs, larvae L3  (680) Zinc 4.5 mM 48 hrs, 4-day adult  (564) Ethanol 2.5% 3 hrs, larvae L3  (239) Ethanol 5% 3 hrs, larvae L3  (161) Ethanol 10% 3 hrs, larvae L3  (208) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (117) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (461) Caffeine 25 mg/ml 48 hrs, 4-day adult  (709) Paraquat 5 mM 48 hrs, 4-day adult  (358) Paraquat 10 mM 48 hrs, 4-day adult  (229) Rotenone 2 μg 12 hrs, larvae L3  (166) Rotenone 8 μg 12 hrs, larvae L3  (122) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (619) cold shock, 4-day adult  (484) heat shock, 4-day adult  (268) Cadmium 50 mM 6 hrs, larvae L3  (169) Cadmium 50 mM 12 hrs, larvae L3  (201) Cadmium 50 mM 48 hrs, 4-day adult  (310) Cadmium 100 mM 48 hrs, 4-day adult  (476) Copper 0.5 mM 12 hrs, larvae L3  (770) Copper 15 mM 48 hrs, 4-day adult  (515) Zinc 5 mM 12 hrs, larvae L3  (680) Zinc 4.5 mM 48 hrs, 4-day adult  (564) Ethanol 2.5% 3 hrs, larvae L3  (239) Ethanol 5% 3 hrs, larvae L3  (161) Ethanol 10% 3 hrs, larvae L3  (208) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (117) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (461) Caffeine 25 mg/ml 48 hrs, 4-day adult  (709) Paraquat 5 mM 48 hrs, 4-day adult  (358) Paraquat 10 mM 48 hrs, 4-day adult  (229) Rotenone 2 μg 12 hrs, larvae L3  (166) Rotenone 8 μg 12 hrs, larvae L3  (122) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    619 cold shock, 4-day adult    484 heat shock, 4-day adult    268 Cadmium 50 mM 6 hrs, larvae L3    169 Cadmium 50 mM 12 hrs, larvae L3    201 Cadmium 50 mM 48 hrs, 4-day adult    310 Cadmium 100 mM 48 hrs, 4-day adult    476 Copper 0.5 mM 12 hrs, larvae L3    770 Copper 15 mM 48 hrs, 4-day adult    515 Zinc 5 mM 12 hrs, larvae L3    680 Zinc 4.5 mM 48 hrs, 4-day adult    564 Ethanol 2.5% 3 hrs, larvae L3    239 Ethanol 5% 3 hrs, larvae L3    161 Ethanol 10% 3 hrs, larvae L3    208 Caffeine 1.5 mg/ml 4 hrs, larvae L3    117 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    461 Caffeine 25 mg/ml 48 hrs, 4-day adult    709 Paraquat 5 mM 48 hrs, 4-day adult    358 Paraquat 10 mM 48 hrs, 4-day adult    229 Rotenone 2 μg 12 hrs, larvae L3    166 Rotenone 8 μg 12 hrs, larvae L3    122 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    619 cold shock, 4-day adult    484 heat shock, 4-day adult    268 Cadmium 50 mM 6 hrs, larvae L3    169 Cadmium 50 mM 12 hrs, larvae L3    201 Cadmium 50 mM 48 hrs, 4-day adult    310 Cadmium 100 mM 48 hrs, 4-day adult    476 Copper 0.5 mM 12 hrs, larvae L3    770 Copper 15 mM 48 hrs, 4-day adult    515 Zinc 5 mM 12 hrs, larvae L3    680 Zinc 4.5 mM 48 hrs, 4-day adult    564 Ethanol 2.5% 3 hrs, larvae L3    239 Ethanol 5% 3 hrs, larvae L3    161 Ethanol 10% 3 hrs, larvae L3    208 Caffeine 1.5 mg/ml 4 hrs, larvae L3    117 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    461 Caffeine 25 mg/ml 48 hrs, 4-day adult    709 Paraquat 5 mM 48 hrs, 4-day adult    358 Paraquat 10 mM 48 hrs, 4-day adult    229 Rotenone 2 μg 12 hrs, larvae L3    166 Rotenone 8 μg 12 hrs, larvae L3    122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (619) cold shock, 4-day adult  (484) heat shock, 4-day adult  (268) Cadmium 50 mM 6 hrs, larvae L3  (169) Cadmium 50 mM 12 hrs, larvae L3  (201) Cadmium 50 mM 48 hrs, 4-day adult  (310) Cadmium 100 mM 48 hrs, 4-day adult  (476) Copper 0.5 mM 12 hrs, larvae L3  (770) Copper 15 mM 48 hrs, 4-day adult  (515) Zinc 5 mM 12 hrs, larvae L3  (680) Zinc 4.5 mM 48 hrs, 4-day adult  (564) Ethanol 2.5% 3 hrs, larvae L3  (239) Ethanol 5% 3 hrs, larvae L3  (161) Ethanol 10% 3 hrs, larvae L3  (208) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (117) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (461) Caffeine 25 mg/ml 48 hrs, 4-day adult  (709) Paraquat 5 mM 48 hrs, 4-day adult  (358) Paraquat 10 mM 48 hrs, 4-day adult  (229) Rotenone 2 μg 12 hrs, larvae L3  (166) Rotenone 8 μg 12 hrs, larvae L3  (122) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (619) cold shock, 4-day adult  (484) heat shock, 4-day adult  (268) Cadmium 50 mM 6 hrs, larvae L3  (169) Cadmium 50 mM 12 hrs, larvae L3  (201) Cadmium 50 mM 48 hrs, 4-day adult  (310) Cadmium 100 mM 48 hrs, 4-day adult  (476) Copper 0.5 mM 12 hrs, larvae L3  (770) Copper 15 mM 48 hrs, 4-day adult  (515) Zinc 5 mM 12 hrs, larvae L3  (680) Zinc 4.5 mM 48 hrs, 4-day adult  (564) Ethanol 2.5% 3 hrs, larvae L3  (239) Ethanol 5% 3 hrs, larvae L3  (161) Ethanol 10% 3 hrs, larvae L3  (208) Caffeine 1.5 mg/ml 4 hrs, larvae L3  117 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (461) Caffeine 25 mg/ml 48 hrs, 4-day adult  (709) Paraquat 5 mM 48 hrs, 4-day adult  (358) Paraquat 10 mM 48 hrs, 4-day adult  (229) Rotenone 2 μg 12 hrs, larvae L3  (166) Rotenone 8 μg 12 hrs, larvae L3  122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    619 cold shock, 4-day adult    484 heat shock, 4-day adult    268 Cadmium 50 mM 6 hrs, larvae L3    169 Cadmium 50 mM 12 hrs, larvae L3    201 Cadmium 50 mM 48 hrs, 4-day adult    310 Cadmium 100 mM 48 hrs, 4-day adult    476 Copper 0.5 mM 12 hrs, larvae L3    770 Copper 15 mM 48 hrs, 4-day adult    515 Zinc 5 mM 12 hrs, larvae L3    680 Zinc 4.5 mM 48 hrs, 4-day adult    564 Ethanol 2.5% 3 hrs, larvae L3    239 Ethanol 5% 3 hrs, larvae L3    161 Ethanol 10% 3 hrs, larvae L3    208 Caffeine 1.5 mg/ml 4 hrs, larvae L3    117 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    461 Caffeine 25 mg/ml 48 hrs, 4-day adult    709 Paraquat 5 mM 48 hrs, 4-day adult    358 Paraquat 10 mM 48 hrs, 4-day adult    229 Rotenone 2 μg 12 hrs, larvae L3    166 Rotenone 8 μg 12 hrs, larvae L3    122 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD24056 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011760 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6998-RB;S.CX000506 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ctp Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal ctpGD4688 lethal (with Df(1)bi-DL1) ctpexc6 lethal | embryonic stage ctpG0089 lethal | embryonic stage | partially | recessive ctpexc6 lethal | embryonic stage | recessive ctpexc3 lethal | heat sensitive ctpDIIA82 ctpins1 lethal | heat sensitive (with Df(1)bi-DL1) ctpDIIA82 ctpins1 lethal | larval stage ctpG0445b lethal | pharate adult stage ctpG0153 ctpG0204 ctpG0207 ctpG0244a ctpG0338 ctpG0371 ctpG0387 ctpG0432 lethal | pupal stage ctpG0338 ctpG0371 ctpG0387 lethal | pupal stage | recessive ctpe55 ctpe73 lethal | recessive ctpexc6 ctpG0153 ctpG0204 ctpG0207 ctpG0244a ctpG0338 ctpG0371 ctpG0387 ctpG0445b ctpPG10 ctpPG54 ctpPG88 ctpPG134 ctpPG139 ctpPG145 ctpPL13 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 ctpGD4688 partially lethal - majority die | recessive ctpG0248 ctpG0432 partially lethal - majority live ctpDIIA82 ctpins1 partially lethal - majority live (with Df(1)bi-DL1) ctpexc39 viable ctp1 ctpe21 ctpe27 ctpexc39 ctpins1 Sterility Allele female sterile ctp1 female sterile | recessive ctpins1 ctpins2 ctpins3 male fertile ctprev male fertile | poor ctpDIIA82 ctpexc39 ctpins1 male semi-sterile (with Df(3L)fz-GF3b) ctpexc39 male sterile ctpG0248 ctpins1 Other Phenotypes Allele behavior defective ctp1 locomotor behavior defective | third instar larval stage ctpG0371 neuroanatomy defective | larval stage ctpGD4688 visible ctp1 visible, with Scer\GAL4pnr-MD237 ctpGD4688 visible (with ctpDIA5) ctpDIIA82 ctpDIIB14 ctpexc6 ctpexc41 ctpins1 visible (with ctpDIIA82) ctpDIA5 ctpDIIB14 ctpexc6 ctpexc41 ctpins1 visible (with ctpDIIB14) ctpDIA5 ctpDIIA82 ctpexc6 ctpexc41 ctpins1 visible (with ctpexc6) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc39 ctpexc41 ctpexc123 ctpins1 visible (with ctpexc39) ctpexc6 visible (with ctpexc41) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc6 ctpins1 visible (with ctpexc123) ctpexc6 visible (with ctpins1) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc6 ctpexc41 visible (with Df(1)bi-DL1) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc39 ctpexc41 ctpexc123 visible | recessive ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc41 ctpins1 wild-type ctpe36 Phenotype manifest in Allele actin filament & spermatid ctpDIIA82 ctpexc39 ctpins1 actin filament bundle & nucleus ctpDIIA82 ctpins1 astral microtubule ctpexc6 astral microtubule (with Df(1)JC70) ctpexc6 chaeta ctpG0153 ctpG0204 ctpG0244a ctpG0432 commissure ctpe73 cystic bulge ctpDIIA82 ctpexc39 ctpins1 egg chamber ctpexc3 ctpexc6 ctpins1 ctpins2 ctpins3 egg chamber | somatic clone ctpexc3 embryonic/larval neuroblast ctpexc6 embryonic/larval neuroblast (with Df(1)JC70) ctpexc6 embryonic/larval neuroblast | larval stage ctpGD4688 embryonic head & macrochaeta ctpe55 ctpe73 ganglion mother cell | larval stage ctpGD4688 head & macrochaeta ctp1 leg & macrochaeta & embryo ctpe55 ctpe73 longitudinal connective ctpe73 lysosome | pupal stage ctpG0371 macrochaeta ctp1 ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc41 ctpins1 macrochaeta (with ctpDIA5) ctpDIIA82 ctpDIIB14 ctpexc41 ctpexc6 ctpins1 macrochaeta (with ctpDIIA82) ctpDIA5 ctpDIIB14 ctpexc41 ctpexc6 ctpins1 macrochaeta (with ctpDIIB14) ctpDIA5 ctpDIIA82 ctpexc41 ctpexc6 ctpins1 macrochaeta (with ctpexc6) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc123 ctpexc39 ctpexc41 ctpins1 macrochaeta (with ctpexc39) ctpexc6 macrochaeta (with ctpexc41) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc6 ctpins1 macrochaeta (with ctpexc123) ctpexc6 macrochaeta (with ctpins1) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc41 ctpexc6 macrochaeta (with Df(1)bi-DL1) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc123 ctpexc39 ctpexc41 mesothoracic femoral chordotonal organ & axon ctpe73 metathoracic femoral chordotonal organ & axon ctpe73 NMJ bouton | third instar larval stage ctpG0371 nucleus & spermatid ctpexc39 ovariole ctpexc3 ctpexc6 ctpins1 ctpins2 ctpins3 prothoracic femoral chordotonal organ & axon ctpe73 prothoracic femoral chordotonal organ & axon & pupa ctpe55 ctpe73 salivary gland | pupal stage ctpG0371 ctpe73 scutum & macrochaeta ctp1 scutum & macrochaeta & embryo ctpe55 ctpe73 scutum & microchaeta ctp1 scutum & microchaeta & embryo ctpe55 ctpe73 seminal vesicle ctpDIIA82 ctpins1 sensory neuron | P-stage ctpe55 ctpe73 spermatid ctpDIIA82 ctpexc39 spermatid cyst ctpDIIA82 ctpexc39 ctpins1 spermatocyte fusome ctpDIIA82 ctpins1 spermatozoon ctpDIIA82 ctpins1 synaptonemal complex | somatic clone ctpexc3 tormogen cell, with Scer\GAL4pnr-MD237 ctpGD4688 trichogen cell, with Scer\GAL4pnr-MD237 ctpGD4688 wing ctpDIA5 ctpDIIA82 ctpDIIB14 ctpG0153 ctpG0204 ctpG0244a ctpG0432 ctpexc41 ctpins1 wing (with ctpDIA5) ctpDIIA82 ctpDIIB14 ctpexc41 ctpexc6 ctpins1 wing (with ctpDIIA82) ctpDIA5 ctpDIIB14 ctpexc41 ctpexc6 ctpins1 wing (with ctpDIIB14) ctpDIA5 ctpDIIA82 ctpexc41 ctpexc6 ctpins1 wing (with ctpexc6) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc123 ctpexc39 ctpexc41 ctpins1 wing (with ctpexc39) ctpexc6 wing (with ctpexc41) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc6 ctpins1 wing (with ctpexc123) ctpexc6 wing (with ctpins1) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc41 ctpexc6 wing (with Df(1)bi-DL1) ctpDIA5 ctpDIIA82 ctpDIIB14 ctpexc123 ctpexc39 ctpexc41 wing & macrochaeta ctpins1 wing vein ctpins1
Classical Alleles ( 49 )
For All Classical Alleles Show
Allele of ctp Class Mutagen Stocks Known lesion ctpG0153 P-element activity 2 -- ctpG0207 P-element activity 2 -- ctpG0244a P-element activity 2 -- ctpG0371 P-element activity 2 -- ctpG0445b P-element activity 2 -- ctpCB-6802-3 1 -- ctpCB-6888-3 1 -- ctpd04061 1 -- ctpf02345 1 -- ctpG0094a P-element activity 1 -- ctpG0204 P-element activity 1 -- ctpG0248 P-element activity 1 -- ctpG0387 P-element activity 1 -- ctpG0432 P-element activity 1 -- ctpKG06321 1 -- ctpe55 amorphic allele - genetic evidence Delta2-3 0 -- ctpe73 amorphic allele - genetic evidence Delta2-3 0 Yes ctpexc3 amorphic allele - genetic evidence Delta2-3 0 Yes ctpexc6 amorphic allele - genetic evidence Delta2-3 0 Yes ctp1 hypomorphic allele - genetic evidence P-element activity 0 Yes ctpCB-0769-3 0 -- ctpCB-6621-3 0 -- ctpd01801 0 -- ctpd05797 P-element activity 0 -- ctpDIA5 Delta2-3 0 Yes ctpDIIA82 hypomorphic allele - genetic evidence Delta2-3 0 Yes ctpDIIB14 Delta2-3 0 Yes ctpe01712 0 -- ctpe21 Delta2-3 0 Yes ctpe27 Delta2-3 0 Yes ctpe36 0 -- ctpexc123 Delta2-3 0 Yes ctpexc39 hypomorphic allele - genetic evidence Delta2-3 0 Yes ctpexc41 Delta2-3 0 Yes ctpG0089 P-element activity 0 -- ctpG0338 P-element activity 0 -- ctpGG01021 0 -- ctpGG01074 0 -- ctpins1 loss of function allele, hypomorphic allele - genetic evidence P-element activity 0 Yes ctpins2 P-element activity 0 -- ctpins3 P-element activity 0 -- ctpPG10 Delta2-3 0 -- ctpPG134 Delta2-3 0 -- ctpPG139 Delta2-3 0 -- ctpPG145 Delta2-3 0 -- ctpPG54 Delta2-3 0 -- ctpPG88 Delta2-3 0 -- ctpPL13 Delta2-3 0 -- ctprev Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ctp Class Mutagen Stocks Known lesion ctpGD4688 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ctpHMS02554 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctpKK115493 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ctpScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes ctpScer\UAS.P\T.cGa in vitro construct - regulatory fusion 0 Yes ctpScer\UAS.T:Avic\GFP-YFP.Venus,T:Uuuu\CAAX in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ctpScer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)bi-D2 (Ghosh-Roy et al., 2004) Df(1)bi-DL1 (Ghosh-Roy et al., 2004) Df(1)ovo6 (Dick et al., 1996) Df(1)RC40 (Phillis et al., 1996)
Not disrupted in	Df(1)DEB4D (Dick et al., 1996) Df(1)EH587 (Dick et al., 1996) Df(1)JC70 (Ghosh-Roy et al., 2004)
Duplicated in	Dp(1;3)DC120 (Popodi et al., 2010-, Venken et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4688} NA P{KK115493} NA P{TRiP.HMS02554} NA P{UAS-ctp.B} NA P{UASp-ctp.G} NA P{UAS-Venus-ctp.CAAX} NA P{UAS-Venus-ctp} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}ctpins2 NA P{}ctpins3 NA P{GT1}BG01970 NA P{RS3}ctpCB-0769-3 NA P{RS3}ctpCB-6621-3 NA P{RS3}ctpCB-6802-3 NA P{RS3}ctpCB-6888-3 NA P{SUPor-P}ctpKG06321 NA PBac{RB}ctpe01712 NA PBac{WH}ctpf02345 NA insertion of mobile activating element P{Mae-UAS.6.11}B2008B2008 NA P{Mae-UAS.6.11}ctpGG01021 NA P{Mae-UAS.6.11}ctpGG01074 NA P{XP}ctpd01801 NA P{XP}ctpd04061 NA P{XP}ctpd05797 NA insertion of enhancer trap P{lacW}ctp1 No P{lacW}ctpG0089 No P{lacW}ctpG0094a No P{lacW}ctpG0153 No P{lacW}ctpG0204 No P{lacW}ctpG0207 No P{lacW}ctpG0244a No P{lacW}ctpG0248 No P{lacW}ctpG0338 No P{lacW}ctpG0371 No P{lacW}ctpG0387 No P{lacW}ctpG0432 No P{lacW}ctpG0445b No P{lacW}ctpins1 No P{lacW}ctpPL13 No insertion of enhancer trap binary system P{GawB}ctpPG10 No P{GawB}ctpPG54 No P{GawB}ctpPG88 No P{GawB}ctpPG134 No P{GawB}ctpPG139 No P{GawB}ctpPG145 No
Gene Ontology: Function, Process & Cellular Component ( 25 unique terms )
Terms Based on Experimental Evidence ( 19 terms )
Molecular Function
CV term Evidence References
dynein intermediate chain binding inferred from physical interaction with sw (Song et al., 2007) protein binding inferred from physical interaction with egg (Stabell et al., 2006) protein homodimerization activity inferred from direct assay (Song et al., 2007)
Biological Process
CV term Evidence References
actin filament bundle assembly inferred from mutant phenotype (Ghosh-Roy et al., 2005) autophagy inferred from mutant phenotype (Batlevi et al., 2010) chaeta development inferred from mutant phenotype (assigned by UniProtKB) (Dick et al., 1996) chaeta morphogenesis inferred from mutant phenotype (Ghosh-Roy et al., 2004) establishment of mitotic spindle orientation inferred from mutant phenotype (Wang et al., 2011) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Ghosh-Roy et al., 2004) microtubule anchoring at centrosome inferred from mutant phenotype (Wang et al., 2011) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) oogenesis inferred from mutant phenotype (assigned by UniProtKB) (Dick et al., 1996) salivary gland cell autophagic cell death inferred from mutant phenotype (Batlevi et al., 2010) spermatid nucleus elongation inferred from mutant phenotype (Ghosh-Roy et al., 2005) spermatogenesis inferred from mutant phenotype (Ghosh-Roy et al., 2004) sperm individualization inferred from mutant phenotype (Ghosh-Roy et al., 2005) wing disc development inferred from mutant phenotype (assigned by UniProtKB) (Dick et al., 1996)
Cellular Component
CV term Evidence References
centriole inferred from direct assay (Wang et al., 2011) cytoplasm inferred from direct assay (assigned by UniProtKB) (Dick et al., 1996)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) microtubule motor activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Biological Process
CV term Evidence References
microtubule-based movement inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
cytoplasmic dynein complex inferred from sequence or structural similarity with EMBL:U32944 (FlyBase, 1992-) non-traceable author statement (Dick, 1995.8.1) cytoskeleton non-traceable author statement (Li et al., 1996) dynein complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ctp - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Bx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10139 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10158 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10249 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10602 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10752 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG10909 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG11109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG11306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG12493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG13385 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ctp - CG13950 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG14020 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG14544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG14667 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG15097 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG15440 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG1607 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG17323 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG17494 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG17601 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG1965 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG2202 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG30195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG30284 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG30324 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG3061 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG31235 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG33213 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG3907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG43795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG44249 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG5118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG5516 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG6153 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG6422 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG6617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG6654 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG6933 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG7048 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG7550 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG8009 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG8079 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ctp - CG8298 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG9090 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG9281 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG9389 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG9754 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CG9911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CalpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Cchl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Cdc27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Cdk5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Cen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Chi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Chmp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Coop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - CrebA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Dip1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Fmrf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - HP1c anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Hmgcr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Inx3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Irp-1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Jra anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Liprin-α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Mp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Mtor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - NTPase anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Nxt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Pitslre anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Prosβ3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - RAF2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Rab9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Rca1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - RhoGDI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - RhoGEF2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - RluA-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - SNCF anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Sar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Sdc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Snr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - TER94 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Tsc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Ublcp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Ubqn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Ugt86De anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Vps25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - Vps4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - ago anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - boly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - bor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - capu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - caup anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - cmet anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - dpn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - dpr14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - dup anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - egl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - elB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - geminin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - gig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - htl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - insv experimental knowledge based (Guruharsha et al., 2011) ctp - key anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - l(1)G0469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - lack anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - mof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - msl-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - msl-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - msl-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - mub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - nxf2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - row anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - sbb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - slp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - sunz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - swa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - tlk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - trsn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - wde anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - woc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ctp - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ctp allele Gene References ctp1 ct (Gramates and Phillis, 1995) ctpDIIA82 Dhc64C (Ghosh-Roy et al., 2004) Gl (Ghosh-Roy et al., 2004) ctpexc39 Gl (Ghosh-Roy et al., 2004) ctpins1 Dhc64C (Ghosh-Roy et al., 2004) Gl (Ghosh-Roy et al., 2004) unspecified Gl (Ghosh-Roy et al., 2005) Hsap\DYNLL1 (Ghosh-Roy et al., 2004) shi (Ghosh-Roy et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57920 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011760 DroID - A comprehensive database of gene and protein interactions. • FBgn0011760 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31405
Orthologs
OrthoDB Orthologs (60) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6V17MK Dipteran inclusive ortholog search EOG6MW8GP Insect inclusive ortholog search EOG60GBNT Arthropod inclusive ortholog search EOG60RXZM Metazoa inclusive ortholog search EOG6Z0Q2C
Orthologs in Drosophila Species (EOG6V17MK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cdlc2     Drosophila melanogaster fruit fly  Dmel\ctp     Drosophila simulans   Dsim\GD23096   Y Drosophila sechellia   Dsec\GM12359 Y Y Drosophila sechellia   Dsec\GM16816   Y Drosophila erecta   Dere\GG18720 Y Y Drosophila erecta   Dere\GG24789   Y Drosophila erecta   Dere\GG24601   Y Drosophila yakuba   Dyak\GE17560   Y Drosophila yakuba   Dyak\ctp Y Y Drosophila ananassae   Dana\GF15181   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA25980   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA26073   Y Drosophila persimilis   Dper\GL15652   Y Drosophila willistoni   Dwil\GK15188   Y Drosophila willistoni   Dwil\GK25335 Y Y Drosophila virilis   Dvir\GJ17036   Y Drosophila virilis   Dvir\GJ17025   Y Drosophila mojavensis   Dmoj\GI14559   Y Drosophila mojavensis   Dmoj\GI14563   Y Drosophila grimshawi   Dgri\GH11410   Y
Orthologs in non-Drosophila Dipterans (EOG6MW8GP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011478 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001335 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015622 Y
Orthologs in non-Dipteran Insects (EOG60GBNT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\DLC-D Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007052 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13830 Y Atta cephalotes Leafcutter ant  Acep\ACEP22571 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18182 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21917 Y Linepithema humile Argentine ant  Lhum\LH10243 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12909 Y Solenopsis invicta Red fire ant  Sinv\SINV16815 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI065028 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI087266 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012762 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15765 Y
Orthologs in non-Insect Arthropods (EOG60RXZM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308639 Y Ixodes scapularis Deer tick  Isca\ISCW003606 Y
Orthologs in non-Arthropod Metazoa (EOG6Z0Q2C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dlc-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008799gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018567gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024499gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008800gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018607gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024498gn Y Danio rerio Zebrafish  Drer\dynll1 Y Danio rerio Zebrafish  Drer\dnl2l Y Danio rerio Zebrafish  Drer\dnl2l Y Xenopus tropicalis Western clawed frog  Xtro\dynll2 Y Xenopus tropicalis Western clawed frog  Xtro\dynll1 Y Gallus gallus Domestic chicken  Ggal\DYNLL2 Y Gallus gallus Domestic chicken  Ggal\GGA.44939 Y Gallus gallus Domestic chicken  Ggal\GGA.46920 Y Mus musculus House mouse  Mmus\Dynll1 Y Mus musculus House mouse  Mmus\Dynll2 Y Rattus norvegicus Norway rat  Rnor\Dynll2 Y Rattus norvegicus Norway rat  Rnor\Dynll1 Y Homo sapiens Human  Hsap\DNCL1 Y Homo sapiens Human  Hsap\DYNLL2 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\DNCL1     Hsap\DYNLL2
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM12359 Drosophila erecta Dere\GG18720 Drosophila yakuba Dyak\ctp Drosophila willistoni Dwil\GK25335
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Bloomington	11851 w67c23 P{lacW}ctpG0153/FM7c 11852 w67c23 P{lacW}ctpG0207/FM7c 11960 w67c23 P{lacW}ctpG0248/FM7c 11988 w67c23 P{lacW}ctpG0371/FM7c 11999 w67c23 P{lacW}ctpG0387/FM7c 12024 w67c23 P{lacW}ctpG0432/FM7c 12228 w67c23 P{lacW}ctpG0204/FM7c 11847 w67c23 P{lacW}ctpG0244a/FM7c
Harvard	- P{XP}ctpd04061 - PBac{WH}ctpf02345
VDRC	v43115 w1118; P{GD4688}v43115 v43116 w1118; P{GD4688}v43116
	More stocks available...
Genomic Clones ( 1 )
	BACR17H06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 416 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24056
Other clones	DPiM_LD24056
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT24687 AT31743 GH05504 GH06754 GH08464 GH14724 GH15477 GH20676 GH21118 GH22793 GH22917 GH25887 GH26601 GH28357 GM03969 GM09669 GM20240 GM30709 GM31385 LD04365 LD07022 LD07170 LD09862 LD11044 LD11277 LD15131 LD27456 LD27966 LD31236 LD33985 LD38391 LD41931 LD43783 LD44869 LP04758 LP04811 LP04905 LP05626 LP05774 LP06401 LP14279 LP21930 RE02741 RE03907 RE06031 RE06302 RE07296 RE07813 RE07943 RE11986 RE15445 RE15761 RE15847 RE16204 RE16421 RE16838 RE17120 RE17888 RE20744 RE22655 RE22737 RE24849 RE26471 RE26781 RE26907 RE29052 RE29314 RE29694 RE29790 RE31612 RE34295 RE36728 RE38301 RE38995 RE40679 RE42240 RE42356 RE43490 RE44540 RE46861 RE47040 RE49989 RE50416 RE52245 RE53578 RE54489 RE55152 RE57747 RE57974 RE59608 RE60012 RE60648 RE62705 RE63211 RE65118 RE65649 RE65833 RE67817 RE72775 RE73110 RE73478 RE74717 RE74944 RH11609 RH19702 RH43445 RH62095 SD10589 SD16495 SD17428 SD23143
Other clones	7531 8778 13653 14418 28054 29407 34195 35777 36861 40068 43394 44819 59873 61539 67596 70250 71477 71873 77011 77442 78401 79528 80647 105224 109296 121246 122079 146307 149572 153270 153305 162187 164753 174336 175246 179170 180037 183554 183900 192029 192031 275212 280637 528133 542807 bs12c09 bs24b03 CK01.1D.F4 CK01.12D.F10 CK01.13D.C12 CK01.16D.C4 CK01.42B.F1 CK01.50C.B10 CK01.51D.G3 CK01.52A.C11 CK01.52A.E2 CK01.55D.G7 CK01.65A.B4 CK01.78A.B8 CK01.78A.G12 CK01.78B.B12 CK01.79B.B6 CK01.84B.G11 CK01.84C.G2 CK01.88C.D10 CK01.89D.G10 CK01.91A.E1 CK01.92B.F1 CK01.92C.D5 CK01.94B.F1 CK01.97B.G4 CK01.97B.H4 CK01.110C.C2 CK01.110D.E9 CK01.110D.H9 CK01.111B.E7 CK01.111C.H8 CK01.112A.G5 CK01.121C.H2 CK01.125A.E11 Dmel_dig_008380_0715_0763 Dmel_dig_008389_0661_2994 Dmel_dig_010837_0632_0419 Dmel_neb_004053_0402_3748 Dmel_neb_012823_0314_2447 Dmel_neb_012915_0916_2541 Dmel_neb_014294_0625_1950 EC39592 EK001227 EK040439 EK042112 EK042249 EK044628 EK045328 EK053038 EK060760 EK060840 EK061038 EK061639 EK067043 EK068926 EK069647 EK070757 EK071317 EK072312 EK073421 EK075205 EK075444 EK092961 EK095420 EK100931 EK105209 EK108125 EK115319 EK116523 EK125659 EK135730 EK137247 EK148010 EK149322 EK153828 EK154304 EK162722 EK167706 EK168124 EK174535 EK186753 EK195650 EK197662 EK199841 EK200523 EK207911 EK209350 EK210730 EK213924 EK215407 EK215921 EK241403 EK242055 EK248964 EK255752 EK255903 EK256663 EK256916 EK259001 EK263635 EK265634 EK267407 EK269158 EK279234 EK284762 EK288554 EK288664 EK295741 EK302719 EK305444 EN03801 EN11354 FGA011C11 FGC018C06 FGC023E05 FGH101H11 FGH106H10 FGH123C01 FGH128H09 FGM225B01 FGM312B01 GH18533 IP04511 IP11981 IP18731 LD01658 LD14527 RE01136 RE03421 RE46390 RE52928 RE54815 RE56996 RE59005 RE71309 RH51368 RH51592 RP003022433 RP003038909 RP003045608 RP003062467 RP003064857 RP003067259 RP003070395 RP003070765 RP003080002 RP003080723 RP003096108 RP003097112 RP003099844 RP003102779 RP003117222 RP003117629 RP003118565 RP003126577 RP003129394 RP003137753 RP003138837 RP003141472 RP003146673 RP003147271 RP003149012 RP003156187 RP003157785 RP003157934 RP003168691 RP003172201 RP003172785 RP003172945 RP003184598 RP003192326 RP003194953 RP003198062 RP003204869 RP003243261 RP003252578 RP003256172 RP003257829 RP003260104 RP003277597 RP003278264 RP003278306 RP003285439 RP003293033 RP003301292 RP003301864 RP003302658 RP003305955 RP003314060 RP003315590 RP003317737 RP003321173 RP003321495 RP003322074 RP003323530 RP003331725 RP003338927 RP003340056 RP003340683 RP003346350 RP003349760 RP003351606 RP003354442 RP003374819 RP003395731 RP003400345 RP003402327 RP003402442 RP003404742 RP003416220 RP003424115 RP003425898 RP003441424 RP003441486 RP003450843 RP003453865 RP003456840 RP003462394 RP003472965 RP003473091 RP003494758 RP003510732 RP003512894 RP003512983 RP003515509 RP003515765 RP003519397 RP003522601 RP003523731 RP003534333 RP003536754 RP003539359 RP003546662 RP003562381 RP003567104 RP003567685 RP003567808 RP003580470 RP003581896 RP003588631 RP003595582 RP003600220 RP003601838 RP003605247 RP003605683 RP003607730 RP003613175 RP003613492 RP003617752 RP003633288 RP003636324 RP003636994 RP003653874 RP003661720 RP003663495 RP003680656 SD12814
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011760 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31405
Antibody Information
	polyclonal (Dick et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ctp CG6998 (Zhao, 1999.11)
Source for database merge of	Source for merge of: ctp anon-WO03040301.128 (FlyBase, 1996-) Source for merge of: ctp Cdlc1 (Murphey et al., 1999) Source for merge of: ctp l(1)G0338 l(1)G0387 l(1)G0204 l(1)G0248 l(1)G0153 l(1)G0207 l(1)G0432 l(1)G0371 (Peter et al., 2002)
Additional comments	The Cdlc2 gene may be derived from the ctp gene by retroposition. (Betran et al., 2002) Source for merge of ctp anon-WO03040301.128 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	ctp interacts with egl through a ctp interaction domain near the C terminus of egl and a well established binding motif in ctp. (Navarro et al., 2004) ctp is a swa-binding protein. (Schnorrer et al., 2000) ctp, a component of the dynein-dynactin complex, appears to have a role in normal terminal branching, synaptogenesis and stabilisation of some sensory neurons. (Murphey et al., 1999) After reaching the CNS, mutant axons exhibit errors in branching within the target domain. (Murphey et al., 1999) Molecular and genetic characterisation of ctp. Partial loss of function mutations cause pleiotrophic morphological defects in adults and total loss of function mutations are lethal and cause embryonic degeneration and wide-spread apoptotic cell death. (Dick et al., 1996) Dlc mutations fail to complement the lethal and female-sterile phenotypes of ctp alleles. Dlc mutations also show the same sensory axon projection defects observed for ctp mutants. (Phillis et al., 1996) ctp is required for proper axon guidance of imaginal sensory neurons. (Phillis et al., 1996) Mutations of ctp enhance the phenotype of lethal I class of ct mutations. ctp has a non-additive interaction with eppy. (Gramates and Phillis, 1995) Mutations cause occasional bristle loss and reduction in bristle length and thickness. (Phillis et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080336 NM_167014 NM_167015 NM_167016 NM_001258601 RefSeq (Proteins) • NP_525075 NP_726942 NP_726943 NP_726944 NP_001245530 DDBJ / EMBL / GenBank • AA392261 AA820434 AAB04148 AAD00072 AAD00074 AAF45975 AAM11151 AAN09126 AAN09127 AAN09128 AFH07244 AI260824 AI945386 AI946354 AJ426676 AJ426678 AJ426679 AJ426683 AJ426684 AJ426685 AJ426686 AJ426687 AX777274 AY094798 BH011447 CZ474730 U32855 U48846 U48848 Entrez Gene - A searchable database of RefSeq genes. • 31405 UniProtKB/Swiss-Prot • Q24117 UniProtKB/TrEMBL • Q8SX77
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dynein light chain, type 1/2 (IPR001372) Dynein light chain, type 1/2, conserved site (IPR019763) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24056
Linkouts
	BioGRID - A database of protein and genetic interactions • 57920 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011760 DroID - A comprehensive database of gene and protein interactions. • FBgn0011760 DRSC - Results from RNAi screens. • FBgn0011760 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011760 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6998-RB;S.CX000506 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011760 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31405 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31405 modMine - Data generated by the modENCODE project. • FBgn0011760
Synonyms & Secondary IDs ( 36 )
Reported As
Symbol Synonym	anon-WO03040301.128   Cdlc1 (Phillis et al., 2001, Phillis et al., 2000, Murphey et al., 1999, ) CG6998 (Lee et al., 2003, Bourbon et al., 2002, Mount, 2001.8.14, Goldstein and Gunawardena, 2000, Grieder et al., 2007, Chang et al., 2008, Keleman et al., 2009.8.5, Cammarato et al., 2011, Ni et al., 2010.12.1) ctp (Liebl et al., 2006, Stabell et al., 2006, Grieder et al., 2007, FlyBase Curators, 2008, Dorus et al., 2006, Jungreis et al., 2011, Nelson et al., 2005, Chang et al., 2008, Lipatov et al., 2005, Dorus et al., 2008, Dorus et al., 2006, Wang et al., 2011, Popodi et al., 2010-, Neumüller et al., 2011, Venken et al., 2010) Ctp (Langille and Clark, 2007) ddlc1 (Ghosh-Roy et al., 2004, Roy and Ray, 2001, Dick, 1995.8.1, Dick et al., 1997, Dick et al., 1996, Ghosh-Roy et al., 2005, Batlevi et al., 2010, Rom et al., 2007) Ddlc-1 (Johnstone and Lasko, 2001, Fischer, 2000, Schnorrer et al., 2000, Bar and Abdu, 2006, Abdu et al., 2006) Ddlc1 (Schnorrer et al., 1999) dlc (Huynh and St. Johnston, 2004) Dlc (Bullock et al., 2006, Bullock et al., 2006, Navarro et al., 2004) DLC8 (Mohan and Hosur, 2008) l(1)G0153 (Schaefer et al., 1999.6.15, ) l(1)G0204 (Schaefer et al., 1999.12.2, ) l(1)G0207 (Schaefer et al., 1999.6.15, ) l(1)G0244   l(1)G0248 (Schaefer et al., 1999.8.12, ) l(1)G0338 (Schaefer et al., 1999.8.12, ) l(1)G0371 (Schaefer et al., 1999.8.12, ) l(1)G0387 (Schaefer et al., 1999.8.12, ) l(1)G0432 (Schaefer et al., 1999.8.12, ) l(1)G0445   LC8 (Wang et al., 2004, Makokha et al., 2002, Barbar et al., 2001, Song et al., 2007, Hall et al., 2009, Lightcap et al., 2008, Nyarko et al., 2004, Nyarko et al., 2005, Benison et al., 2007)
Name Synonym	8kd dynein light chain (Li, 1996.2.9, Li, 1996.2.9) cut up (Stabell et al., 2006, Nelson et al., 2005, Chang et al., 2008, van Eyk et al., 2011, Cammarato et al., 2011) Cytoplasmic dynein (Welte, 2004) cytoplasmic dynein (de Heredia and Jansen, 2004, Gonczy, 2002) Cytoplasmic dynein 8kD light chain (Murphey et al., 1997) cytoplasmic dynein light chain 1 (Goldstein and Gunawardena, 2000) Cytoplasmic dynein light chain 1   dynein (Kalinovsky and Scheiffele, 2004, Kuznetsov, 2011) dynein light chain (Stebbings, 2000, Phillis et al., 1997, Li et al., 1995, Navarro et al., 2004, Shav-Tal and Singer, 2005) Dynein light chain (Abdu et al., 2006, Mohan and Hosur, 2008, Rom et al., 2007) dynein light-chain (Nyarko et al., 2004) dynein light-chain 1 (Dick et al., 1996) dynein light chain 1 (Ghosh-Roy et al., 2005) Dynein light chain 1 (Batlevi et al., 2010)
Secondary FlyBase IDs
	FBgn0015619 FBgn0015650 FBgn0027256 FBgn0027271 FBgn0027293 FBgn0028265 FBgn0028273 FBgn0028298 FBgn0028309 FBgn0028322 FBgn0028337 FBgn0040189 FBgn0066852
References ( 110 )
Generate a list of	All references relating to this gene ( 110 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 14 ) Review  ( 11 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 14 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Patent  ( 1 )
Recent research papers ( 7 )
	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Joti et al., 2011, Sci. Rep. 1: 173 Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila. [FBrf0217480] Kuznetsov, 2011, Comput. Methods. Biomech. Biomed. Engin. 14(12): 1117--1131 Modelling active transport in Drosophila unipolar motor neurons. [FBrf0216800] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Otani et al., 2011, Dev. Cell 20(2): 219--232 IKKɛ Regulates Cell Elongation through Recycling Endosome Shuttling. [FBrf0212985] van Eyk et al., 2011, Hum. Mol. Genet. 20(14): 2783--2794 Perturbation of the Akt/Gsk3-{beta} signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. [FBrf0213942] Wang et al., 2011, Dev. Cell 21(3): 520--533 An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. [FBrf0215580] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...