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Gene Dmel\DNApol-α50

General Information
Symbol	Dmel\DNApol-α50	Species	D. melanogaster
Name	DNA polymerase α 50kD	Annotation symbol	CG7108
Feature type	protein_coding_gene	FlyBase ID	FBgn0011762
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	pol α, polα, DNApol-alpha50
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66C7-66C8	Sequence location	3L:8,333,420..8,337,504 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene DNA polymerase α 50kD is referred to in FlyBase by the symbol Dmel\DNApol-α50 (CG7108, FBgn0011762). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process: DNA replication; neurogenesis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA primase, small subunit; DNA primase, small subunit, eukaryotic/archaeal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1633854_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of DNApol-alpha50. Gene sequence location is 3L:8333420..8337504.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Clones RP003077816
FB2012_01	Sequence features BKN22117 HFA11137
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66C7-66C8   Limits computationally determined from genome sequence between P{lacW}l(3)L0139L0139 and P{PZ}Gug03928&P{EP}CG6745EP595b
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\DNApol-α50 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) DNApol-α50-RA FBtr0076603  NM_079248   1563   438
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein DNApol-α50-PA   FBpp0076330   50.2   438   7.55     NP_523972   AAF50439
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA primase, small subunit (IPR002755) DNA primase, small subunit, eukaryotic/archaeal (IPR014052)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696124   AE014296 AAF50439   AI514104   AI544015   AX154908   AY071217 AAL48839   BI228518   BI236996   BI237063   BI482165   BI486485   BI578634   BP547699   CA803512   CO271742   CO282217   CO292320   CO301836   CO339920   CZ490220   EC063598   EC245430   EC258110   EV594683   GH749049   GH749400   GH750774   GH752060   GH753442   GH753504   GH755376   GH772785   GH776183   GH781180   GH784716   GH785887   GH790364   GH793359   GH799413   GH806338   GH808781   GH812055   GH813837   GH817226   GH818694   GH820604   GH820919   GH824457   GH835250   GH837622   GH840389   GH843154   GH843227   GH846510   GH850295   GH855849   GH857567   GH871733   GH873834   GH879348   GH879554   GH879703   GH882736   GH883289   GH887682   GH893163   GH894972   GH901687   GH901945   GH903402   GH906328   GH909137   GH911536   GH916131   GH917468   GH920576   GH922076   GH922640   GH923731   GH924336   GH924610   GH924689   GH926643   GH931818   GH936163   GH937386   S74013   X79801 CAA56196
UniProtKB/Swiss-Prot	Q24317
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011762    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011762 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011762 expression level Developmental Stage   Expression Level embryo 00-02hr    2132 embryo 02-04hr    2228 embryo 04-06hr    2757 embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2132) embryo 02-04hr  (2228) embryo 04-06hr  (2757) embryo 06-08hr  (1320) embryo 08-10hr  (887) embryo 10-12hr  (443) embryo 12-14hr  (318) embryo 14-16hr  (277) embryo 16-18hr  (319) embryo 18-20hr  (189) embryo 20-22hr  (154) embryo 22-24hr  (173) larva L1  (427) larva L2  (496) larva L3 12hr old  (274) larva L3 puffstage 1-2  (222) larva L3 puffstage 3-6  (246) larva L3 puffstage 7-9  (321) white prepupae new  (257) white prepupae 12hr  (385) white prepupae 24hr  (177) pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP  (120) adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day  (493) adult female 05day  (1287) adult female 30day  (1137) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2132) embryo 02-04hr  (2228) embryo 04-06hr  (2757) embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2132 embryo 02-04hr    2228 embryo 04-06hr    2757 embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2132 embryo 02-04hr    2228 embryo 04-06hr    2757 embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011762 expression level Developmental Stage   Expression Level embryo 00-02hr    2132 embryo 02-04hr    2228 embryo 04-06hr    2757 embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2132) embryo 02-04hr  (2228) embryo 04-06hr  (2757) embryo 06-08hr  (1320) embryo 08-10hr  (887) embryo 10-12hr  (443) embryo 12-14hr  (318) embryo 14-16hr  (277) embryo 16-18hr  (319) embryo 18-20hr  (189) embryo 20-22hr  (154) embryo 22-24hr  (173) larva L1  (427) larva L2  (496) larva L3 12hr old  (274) larva L3 puffstage 1-2  (222) larva L3 puffstage 3-6  (246) larva L3 puffstage 7-9  (321) white prepupae new  (257) white prepupae 12hr  (385) white prepupae 24hr  (177) pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP  120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day  (493) adult female 05day  (1287) adult female 30day  (1137) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2132 embryo 02-04hr  2228 embryo 04-06hr  (2757) embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2132 embryo 02-04hr    2228 embryo 04-06hr    2757 embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2132 embryo 02-04hr    2228 embryo 04-06hr    2757 embryo 06-08hr    1320 embryo 08-10hr    887 embryo 10-12hr    443 embryo 12-14hr    318 embryo 14-16hr    277 embryo 16-18hr    319 embryo 18-20hr    189 embryo 20-22hr    154 embryo 22-24hr    173 larva L1    427 larva L2    496 larva L3 12hr old    274 larva L3 puffstage 1-2    222 larva L3 puffstage 3-6    246 larva L3 puffstage 7-9    321 white prepupae new    257 white prepupae 12hr    385 white prepupae 24hr    177 pupae 2d postWPP    86 pupae 3d postWPP    57 pupae 4d postWPP    120 adult male 01day    83 adult male 05day    40 adult male 30day    59 adult female 01day    493 adult female 05day    1287 adult female 30day    1137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011762    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011762 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011762 expression level Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011762 expression level Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    81.15 Larval Midgut no informative data Larval Hindgut    35.4 Larval Malpighian Tubules    28.9 Larval Fat Body    26.3 Larval Salivary Gland    65.7 Larval Trachea    60.3 Larval Carcass    31.35 Adult Head    16 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    24.8 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    20.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    227.5 Adult Testis    4.3 Adult Male Accessory Gland    9.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    16   NA  Eye    no informative data   NA  Brain    no informative data   81.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    18.8   NA  Crop    no informative data   no informative data  Midgut    no informative data   35.4  Hindgut    24.8   28.9  Malpighian Tubules    no informative data   26.3  Fat Body    no informative data   65.7  Salivary Gland    no informative data   NA  Heart    7.45   60.3  Trachea    NA   NA  VirginFemale Spermatheca    20.6   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    227.5   NA  Testis    4.3   NA  Male Accessory Gland    9.4   31.35  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011762 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7108-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 DNApol-α50GD4566 lethal, with Scer\GAL4pnr-MD237 DNApol-α50GD4566 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 DNApol-α50GD4566 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 DNApol-α50GD4566 ganglion mother cell | larval stage, with Scer\GAL41407 DNApol-α50GD4566
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of DNApol-α50 Class Mutagen Stocks Known lesion DNApol-α50f02992 piggyBac transposase 2 -- DNApol-α50f07480 piggyBac transposase 1 -- DNApol-α50G3879 P-element activity 1 -- DNApol-α50G6398 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of DNApol-α50 Class Mutagen Stocks Known lesion DNApol-α50GD4566 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6112 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}DNApol-α50f02992 NA PBac{WH}DNApol-α50f07480 NA insertion of mobile activating element P{EP}DNApol-α50G3879 NA P{EP}DNApol-α50G6398 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
DNA replication inferred from direct assay (Kaguni et al., 1983, Villani et al., 1980) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
alpha DNA polymerase:primase complex inferred from direct assay (Kaguni et al., 1983, Villani et al., 1980)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA-directed DNA polymerase activity inferred from sequence or structural similarity (Bakkenist and Cotterill, 1994) inferred from sequence or structural similarity with UniProtKB:P49642 (FlyBase, 1992-) non-traceable author statement (Cotterill, 1994.6.20) DNA primase activity inferred from electronic annotation with InterPro:IPR002755, InterPro:IPR014052 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Biological Process
CV term Evidence References
DNA replication non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) DNA replication, synthesis of RNA primer inferred from electronic annotation with InterPro:IPR002755, InterPro:IPR014052 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Bakkenist and Cotterill, 1994)
Cellular Component
CV term Evidence References
alpha DNA polymerase:primase complex inferred from sequence or structural similarity (Bakkenist and Cotterill, 1994) inferred from sequence or structural similarity with UniProtKB:P49642 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions DNApol-α50 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64360 DroID - A comprehensive database of gene and protein interactions. • FBgn0011762 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38942
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10290 Dere\GG14305 Dgri\GH15058 Dmoj\GI12823 Dper\GL24698 Dpse\GA20108 Dsec\GM25047 Dsim\GD14084 Dvir\GJ12966 Dwil\GK11955 Dyak\GE20733
Curated drosophilid orthologs	Dpse\GA20108
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014314-PA Aedes aegypti (mosquito) AGAP006065-PA Anopheles gambiae (mosquito) XP_001950179.1 Acyrthosiphon pisum (pea aphid) At5g41880.1 Arabidopsis thaliana (wall cress) 12476 Batrachochytrium dendrobatidis (chytrid fungus) 84141 Branchiostoma floridae (lancelet) BGIBMGA006931-PA Bombyx mori (silk worm) CAL0004759 Candida albicans (a form of yeast) CN24637 Caenorhabditis brenneri (small nematode) CBP16772 Caenorhabditis briggsae (nematode) CE00220 Caenorhabditis elegans (worm) ENSCAFP00000000208 Canis familiaris (dog) CAGL0L09471g Candida glabrata (haploid yeast) ENSCINP00000014188 Ciona intestinalis (sea squirt) JA04294 Caenorhabditis japonica (nematode) CMO313C Cyanidioschyzon merolae (red alga) cn05167 Cryptococcus neoformans (yeast-like fungus) cgd4_1490 Cryptosporidium parvum (protozoan parasite) CPIJ000325 Culex pipens (mosquito) ENSCPOP00000014464 Cavia porcellus (guinea pig) 112983 Chlamidomonas reinhardtii (green alga) RP11981 Caenorhabditis remanei (nematode) ENSCSAVP00000010553 Ciona savignyi (sedentary tunicate) 172979 Capitella spl (polychaete worm) DDB0232279 Dictyostelium discoideum (amoeba) DEHA2D13838g Debaryomyces Hansenii (yeast) 206450 Daphnia pulex (daphnia) ENSDARP00000095418 Danio rerio (zebra fish) ENSECAP00000013166 Equus caballus (horse) XP_649456 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000020110 Gymnopilus aculeatus (mushroom) GL50803_114670 Giardia lamblia (flagellated protozoan) 102735 Hypsipyla robusta (cedar shoot borer) ENSP00000350491 Homo sapiens (human) KLLA0B11682g Kluyveromyces lactis (yeast) LmjF22.0390 Leishmania major (virus) ENSMMUP00000030690 Macaca mulatta (rhesus monkey) ENSMUSP00000026461 Mus musculus (house mouse) 170128 Nematostella vectensis (starlet anemone) XP_001601538.1 Nasonia vitripennis (wasp) ENSOANP00000012906 Ornithorynchus anatinus (platypus) ENSORLP00000015369 Oryzias latipes (japanese killifish) LOC_Os05g29010.2 Oryza sativa (asian rice) PF14_0366 Plasmodium falciparum (protozoal parasite) PP24329 Pristionchus pacificus (nematode) 131719 Physcomitrella patens (moss) ENSPPYP00000005323 Pongo pygmaeus (orangutan) 77227 Phytophthora ramorum (sudden oak death pathogen) 143617 Phytophthora sojae (root rot pathogen) 711657 Populus trichocarpa (black cottonwood) ENSPTRP00000041095 Pan troglodytes (chimpanzee) PVX_118560 Plasmodium vivax (protozoal parasite) ENSRNOP00000051344 Rattus norvegicus (norway rat) 4852058 Sorghum bicolor (sorghum) YIR008C Saccharomyces cerevisiae (budding yeast) Smp_160190 Schistosoma mansoni (trematode parasite) SPAC6B12.10c Schizosaccharomyces pombe (fission yeast) XP_791278.2 Strongylocentrotus purpuratus (purple sea urchin) 26575 Trichoplax adhaerens (metazoa) TA15420 Theileria annulata (apicomplexan parasite) XP_971054.2 Tribolium castaneum (red flour beetle) Tc00.1047053511809.70 Trypanosoma cruzi (parasitic trypanosome) TP02_0837 Theileria parva (parasitic protozoan) 1622 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000908 Takifugu rubripes (pufferfish Takifugu) 3810.m02077 Tetrahymena thermophila (ciliate protozoa) 83673.m00026 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000054212 Xenopus tropicalis (frog) YALI0B11396g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17404 NV10517 LH23908 ISCW009122 FBgn0238036 FBgn0213966 FBgn0200200 FBgn0185776 FBgn0179908 JGI_V11_206450 FBgn0080104 FBgn0162286 FBgn0135580 FBgn0122533 FBgn0106566 FBgn0087331 CPIJ000325 BGIBMGA006931 ACYPI008656 GB10597 AGAP006065 AAEL014314 PB22395 PHUM012430 GLEAN_11690
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18605 w1118; PBac{WH}DNApol-α50f02992/TM6B, Tb1 27205 y1 w*; P{EP}DNApol-α50G6398/TM3, Sb1 Ser1 27137 y1 w*; P{EP}DNApol-α50G3879 CG7083G3879/TM3, Sb1 Ser1
Harvard	- PBac{WH}DNApol-α50f02992 - PBac{WH}DNApol-α50f07480
VDRC	v43870 w1118; P{GD4566}v43870
Genomic Clones ( 1 )
	BACR13E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE26079
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH27162 GM05107 LD46032 RE33137 RE33219 RE64823 RE69920 RE72527
Other clones	44566 71455 214247.75 Dmel_neb_009574_0564_2701 EK104502 EK159830 EK182303 EK199829 EP09644 ESG011b.E21_F02 FGH119G07 RP003003383 RP003023674 RP003041282 RP003060099 RP003068107 RP003077816 RP003090080 RP003094481 RP003095944 RP003113465 RP003115204 RP003133239 RP003146139 RP003149945 RP003160369 RP003164893 RP003179684 RP003182649 RP003183754 RP003189633 RP003207865 RP003242137 RP003242553 RP003265449 RP003281086 RP003281157 RP003281840 RP003297423 RP003303414 RP003305050 RP003317110 RP003321521 RP003333976 RP003349999 RP003350713 RP003355545 RP003358696 RP003386472 RP003387704 RP003395952 RP003404174 RP003451486 RP003454272 RP003454589 RP003481609 RP003484556 RP003498234 RP003507520 RP003525760 RP003528898 RP003530868 RP003544888 RP003557506 RP003573446 RP003582514 RP003612214 RP003613340 RP003616936 RP003618678 RP003637097 RP003646292 RP003669601
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011762 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38942
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: DNApol-α50 anon-WO0140519.257 (FlyBase, 1996-)
Additional comments	Source for merge of DNApol-α50 anon-WO0140519.257 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Subunits of DNA polymerase α and δ are purified from embryos and characterised. (Mitsis et al., 1995) DNApol-α50 has been cloned and characterised. Expression patterns of DNApol-α50 protein and transcript throughout development are consistent with a role of the protein in DNA replication. (Bakkenist and Cotterill, 1994) The properties of the DNA polymerase α enzyme have been studied. (Cai et al., 1993) 25bp DNA oligomer containing m4T is used in a gel extension assay to measure the efficiency of incorporation of dATP and dGTP opposite m4T using a DNA polymerase α-primase complex. The DNA polymerase α shows a clear preference for pairing with dGTP. (Dosanjh et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079248 RefSeq (Proteins) • NP_523972 DDBJ / EMBL / GenBank • AAF50439 AAL48839 AX154908 AY071217 BI228518 BI236996 CAA56196 CZ490220 S74013 X79801 Entrez Gene - A searchable database of RefSeq genes. • 38942 UniProtKB/Swiss-Prot • Q24317
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA primase, small subunit (IPR002755) DNA primase, small subunit, eukaryotic/archaeal (IPR014052)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64360 DroID - A comprehensive database of gene and protein interactions. • FBgn0011762 DRSC - Results from RNAi screens. • FBgn0011762 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011762 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7108-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011762 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38942 InParanoid A subset of ortholog calls from InParanoid. • AAEL014314-PA Aedes aegypti (mosquito) AGAP006065-PA Anopheles gambiae (mosquito) XP_001950179.1 Acyrthosiphon pisum (pea aphid) At5g41880.1 Arabidopsis thaliana (wall cress) 12476 Batrachochytrium dendrobatidis (chytrid fungus) 84141 Branchiostoma floridae (lancelet) BGIBMGA006931-PA Bombyx mori (silk worm) CAL0004759 Candida albicans (a form of yeast) CN24637 Caenorhabditis brenneri (small nematode) CBP16772 Caenorhabditis briggsae (nematode) CE00220 Caenorhabditis elegans (worm) ENSCAFP00000000208 Canis familiaris (dog) CAGL0L09471g Candida glabrata (haploid yeast) ENSCINP00000014188 Ciona intestinalis (sea squirt) JA04294 Caenorhabditis japonica (nematode) CMO313C Cyanidioschyzon merolae (red alga) cn05167 Cryptococcus neoformans (yeast-like fungus) cgd4_1490 Cryptosporidium parvum (protozoan parasite) CPIJ000325 Culex pipens (mosquito) ENSCPOP00000014464 Cavia porcellus (guinea pig) 112983 Chlamidomonas reinhardtii (green alga) RP11981 Caenorhabditis remanei (nematode) ENSCSAVP00000010553 Ciona savignyi (sedentary tunicate) 172979 Capitella spl (polychaete worm) DDB0232279 Dictyostelium discoideum (amoeba) DEHA2D13838g Debaryomyces Hansenii (yeast) 206450 Daphnia pulex (daphnia) ENSDARP00000095418 Danio rerio (zebra fish) ENSECAP00000013166 Equus caballus (horse) XP_649456 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000020110 Gymnopilus aculeatus (mushroom) GL50803_114670 Giardia lamblia (flagellated protozoan) 102735 Hypsipyla robusta (cedar shoot borer) ENSP00000350491 Homo sapiens (human) KLLA0B11682g Kluyveromyces lactis (yeast) LmjF22.0390 Leishmania major (virus) ENSMMUP00000030690 Macaca mulatta (rhesus monkey) ENSMUSP00000026461 Mus musculus (house mouse) 170128 Nematostella vectensis (starlet anemone) XP_001601538.1 Nasonia vitripennis (wasp) ENSOANP00000012906 Ornithorynchus anatinus (platypus) ENSORLP00000015369 Oryzias latipes (japanese killifish) LOC_Os05g29010.2 Oryza sativa (asian rice) PF14_0366 Plasmodium falciparum (protozoal parasite) PP24329 Pristionchus pacificus (nematode) 131719 Physcomitrella patens (moss) ENSPPYP00000005323 Pongo pygmaeus (orangutan) 77227 Phytophthora ramorum (sudden oak death pathogen) 143617 Phytophthora sojae (root rot pathogen) 711657 Populus trichocarpa (black cottonwood) ENSPTRP00000041095 Pan troglodytes (chimpanzee) PVX_118560 Plasmodium vivax (protozoal parasite) ENSRNOP00000051344 Rattus norvegicus (norway rat) 4852058 Sorghum bicolor (sorghum) YIR008C Saccharomyces cerevisiae (budding yeast) Smp_160190 Schistosoma mansoni (trematode parasite) SPAC6B12.10c Schizosaccharomyces pombe (fission yeast) XP_791278.2 Strongylocentrotus purpuratus (purple sea urchin) 26575 Trichoplax adhaerens (metazoa) TA15420 Theileria annulata (apicomplexan parasite) XP_971054.2 Tribolium castaneum (red flour beetle) Tc00.1047053511809.70 Trypanosoma cruzi (parasitic trypanosome) TP02_0837 Theileria parva (parasitic protozoan) 1622 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000908 Takifugu rubripes (pufferfish Takifugu) 3810.m02077 Tetrahymena thermophila (ciliate protozoa) 83673.m00026 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000054212 Xenopus tropicalis (frog) YALI0B11396g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38942 modMine - Data generated by the modENCODE project. • FBgn0011762 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17404 NV10517 LH23908 ISCW009122 FBgn0238036 FBgn0213966 FBgn0200200 FBgn0185776 FBgn0179908 JGI_V11_206450 FBgn0080104 FBgn0162286 FBgn0135580 FBgn0122533 FBgn0106566 FBgn0087331 CPIJ000325 BGIBMGA006931 ACYPI008656 GB10597 AGAP006065 AAEL014314 PB22395 PHUM012430 GLEAN_11690
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	anon-WO0140519.257   CG7108 (Dimova et al., 2003, ) Dmpol α (Takeuchi et al., 2004) DNApol-alpha50 (Giot et al., 2003, Neumüller et al., 2011) DNA polα (Frolov et al., 2003) DNApolα (Cai et al., 1993) DNApol-α (Shen et al., 1992) DNApolα50 (Brumby et al., 2004) DNApol-α50 (Cayirlioglu et al., 2003) Dpri50 (Cotterill, 1994.6.20, ) Pol (Machida et al., 2005) POLA (Matsukage et al., 1995) pol α (Mizushina et al., 2003, Singer and Dosanjh, 1990) polα (Royzman and Orr-Weaver, 1998) Polα (Lehman, 1998) polα50 (Crevel et al., 2001) PRI1 (Mushegian et al., 1998)
Name Synonym	DNA polymerase 50K (Hochheimer et al., 2002) DNA polymerase alpha 50 kda primase subunit (Bakkenist, 1995.5.12) DNA-polymerase α (Leclerc et al., 1996) DNA polymerase α (Kamakaka et al., 1994, Marton et al., 1994, Mitsis et al., 1993, Matsukage et al., 1995) DNA polymerase α 46,000 γ subunit (Villani et al., 1980) DNA polymerase α 50,000 γ subunit (Kaguni et al., 1983) DNA polymerase α 50kD   p50 subunit of DNA polymerase α (Curbo et al., 2003)
Secondary FlyBase IDs
	FBgn0044611
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...