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FB2025_02
,
released April 17, 2025
dDP, l(2)vr10, DP1
transcription factor - obligate dimerization partner of E2f1 and E2f2 - required for normal cell proliferation, optimal DNA synthesis, and efficient G2/M progression
Please see the JBrowse view of Dmel\Dp for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
1.2 (longest cDNA)
None of the polypeptides share 100% sequence identity.
445 (aa); 50 (kD observed)
377 (aa)
Heterodimer of E2f and Dp. Cooperate to give sequence-specific DNA binding and optimal trans-activation. Component of the DREAM complex at least composed of Myb, Caf1-55, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, HDAC1/Rpd3 and l(3)mbt.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dp using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
In syncytial embryos, Dp transcripts are clumped around migrating nuclei. Upon cellularization, they become localized below the nuclei. In early gastrulation, Dp transcripts are localized fairly uniformly and at later stages of germ band extension, they are apparent mainly in regions with dividing cells. In later embryonic stages, Dp expression is confined to the nervous system. Dp transcripts are restricted to proliferating cells in later developmental stages as well. Dp transcripts are observed in the third instar larval brain Dp transcripts are observed in the optic lobe and in the ventral ganglion. They are observed in leg discs and in antennal discs. In eye discs, expression is observed anterior to the morphogenetic furrow, in a stripe just behind it, and at a lower level over the rest of the disc. Expression is also observed in the testis through the spermatocyte growing stages.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dp in JBrowse
2-68
2-71.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages.
Dp is required for several essential processes during oogenesis, including dorsal-ventral patterning and germline cell cycle control.
Identification: One of a collection of genes identified with defective larval growth that extend larval life.
In vitro binding studies of E2f and Dp to the DNApol-α180 promoter region reveals each of the E2f binding sites plays a distinct role as positive or negative element in the regulation of the DNApol-α180 promoter during development.
