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Gene Dmel\Dsp1

General Information
Symbol	Dmel\Dsp1	Species	D. melanogaster
Name	Dorsal switch protein 1	Annotation symbol	CG12223
Feature type	protein_coding_gene	FlyBase ID	FBgn0011764
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	14B14-14B15	Sequence location	X:16,227,645..16,234,476 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dorsal switch protein 1 is referred to in FlyBase by the symbol Dmel\Dsp1 (CG12223, FBgn0011764). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA bending activity; TBP-class protein binding; transcription factor binding; DNA binding. There is experimental evidence that it is involved in the biological process: negative regulation of antimicrobial humoral response; segment specification; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of DNA binding; negative regulation of transcription from RNA polymerase II promoter; leg disc development; developmental process; chromatin remodeling. 14 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; organ system; abdominal ventral denticle belt; cuticle; adult mesothoracic segment; adult abdominal segment; egg; thoracic segment; abdominal 5 ventral denticle belt; external compound sense organ; integumentary plate. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: HMG box A DNA-binding domain, conserved site; High mobility group, HMG1/HMG2; High mobility group, HMG1/HMG2, subgroup; High mobility group, superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624766_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Dsp1. Gene sequence location is X:16227645..16234476.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Huen and Russell, 2010, BMC Bioinformatics 11: 359 Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features BKN45851 HFA20315 BKN27579 Controlled Vocabulary Terms TBP-class protein binding negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14B14-14B15   Limits computationally determined from genome sequence between P{EP}Cyp1EP1073&P{EP}Dsp1EP355 and P{EP}EP1493EP1493
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14D-14D     (Locker, 1994.9.12) 14D-14D     (Locker, 1995.7.19) 14D1-14D4     (Canaple et al., 1997) 14C-14D   (determined by in situ hybridisation)   (Lehming et al., 1994)
Experimentally Determined Recombination Data
Location	1- (Locker, 1995.7.19)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dsp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST data suggest additional 3' exon(s)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dsp1-RA FBtr0089260  NM_167503   3990   385 Dsp1-RB FBtr0089259  NM_167504   3915   385 Dsp1-RC FBtr0089261  NM_080715   4511   385 Dsp1-RD FBtr0089262  NM_167502   2903   386 Dsp1-RE FBtr0089263  NM_206762   4059   393 Dsp1-RF FBtr0289960  NM_001144731   2201   397
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dsp1-PA   FBpp0088319   43.9   385   8.71     NP_727960   AAN09395 Dsp1-PB   FBpp0088318   43.9   385   8.71     NP_727961   AAN09396 Dsp1-PC   FBpp0088320   43.9   385   8.71     NP_542446   AAF48594 Dsp1-PD   FBpp0089257   44.0   386   8.71     NP_727959   AAN09394 Dsp1-PE   FBpp0089258   44.9   393   8.70     NP_996485   AAS65386 Dsp1-PF   FBpp0288398   45.3   397   8.70     NP_001138203   ACL82935
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • HMG box A DNA-binding domain, conserved site (IPR017967) High mobility group, HMG1/HMG2, subgroup (IPR000135) High mobility group, HMG1/HMG2 (IPR000910) High mobility group, superfamily (IPR009071)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391159   AA441057   AA695083   AE014298 AAF48594   AE014298 AAN09394   AE014298 AAN09395   AE014298 AAN09396   AE014298 AAS65386   AE014298 ACL82935   AI113748   AQ025322   AW941922   AY060841 AAL28389   AY095098   BI163180   BI167326   BI169760   BI172798   BI214265   BI214286   BI215637   BI228349   BI229616   BI236351   BI239539   BI243483   BI355041   BI367529   BI368076   BI370202   BI482384   BI482682   BI484432   BI484648   BI577937   BI579452   BP554295   BP554296   BT099920   BT126193   CO181047   CO187116   CO187699   CO187968   CO188224   CO189594   CO189848   CO190969   CO263179   CO269468   CO278625   CO278678   CO278862   CO279473   CO282425   CO283601   CO286763   CO287555   CO288709   CO288815   CO290410   CO291148   CO292116   CO293009   CO295824   CO296570   CO296903   CO296918   CO301370   CO301586   CO305257   CO306354   CO308987   CO311536   CO314074   CO314625   CO315886   CO315927   CO316312   CO321024   CO321614   CO322737   CO323865   CO325432   CO326737   CO331332   CO333524   CO333621   CO340113   CO341077   CO341307   CO344965   CO345522   CZ475687   CZ484859   EC059250   EC062872   EC063265   EC067639   EC067959   EC068019   EC069212   EC074249   EC074577   EC079789   EC080775   EC086532   EC088745   EC089366   EC200829   EC201492   EC205087   EC214609   EC226681   EC226804   EC230496   EC230654   EC230820   EC232309   EC234044   EC240867   EC241253   EC252039   EC255951   EC256302   EC259066   EC259772   EC260391   EV579476   EV581399   EV588636   EV589541   EV592538   EV596948   EV597366   EV597652   EV599970   GH738930   GH738993   GH739228   GH739665   GH739667   GH739869   GH739873   GH739892   GH739976   GH740252   GH741129   GH741178   GH741323   GH741345   GH741441   GH741584   GH741683   GH741697   GH741823   GH742044   GH742073   GH742100   GH742118   GH742467   GH742562   GH742632   GH742763   GH742927   GH743130   GH743204   GH743211   GH743282   GH743724   GH743820   GH743872   GH744015   GH744018   GH744217   GH744336   GH744442   GH744530   GH744588   GH744774   GH745179   GH745540   GH745665   GH746039   GH746112   GH746167   GH746579   GH746610   GH746832   GH746911   GH747016   GH747055   GH747148   GH761459   GH761614   GH761671   GH761776   GH761787   GH761873   GH761958   GH761965   GH761996   GH762241   GH762334   GH762817   GH762855   GH763162   GH763702   GH764419   GH764570   GH764622   GH764623   GH764820   GH764869   GH765326   GH765418   GH765448   GH765739   GH765763   GH765835   GH766095   GH766329   GH766492   GH766717   GH766911   GH767038   GH767040   GH767111   GH767334   GH767338   GH767688   GH767921   GH768485   GH768540   GH768546   GH768551   GH768678   GH768776   GH769139   GH769294   GH769383   GH769404   GH769767   GH779326   GH779455   GH959162   GH959497   U13881 AAA50238   X81456 CAA57212   X89811 CAA61938
UniProtKB/Swiss-Prot	Q24537
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011764    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011764 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011764 expression level Developmental Stage   Expression Level embryo 00-02hr    2784 embryo 02-04hr    5407 embryo 04-06hr    7442 embryo 06-08hr    8768 embryo 08-10hr    6781 embryo 10-12hr    4417 embryo 12-14hr    4292 embryo 14-16hr    2610 embryo 16-18hr    2406 embryo 18-20hr    2106 embryo 20-22hr    1730 embryo 22-24hr    1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6    1651 larva L3 puffstage 7-9    2133 white prepupae new    2591 white prepupae 12hr    2213 white prepupae 24hr    2626 pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day    1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2784) embryo 02-04hr  (5407) embryo 04-06hr  (7442) embryo 06-08hr  (8768) embryo 08-10hr  (6781) embryo 10-12hr  (4417) embryo 12-14hr  (4292) embryo 14-16hr  (2610) embryo 16-18hr  (2406) embryo 18-20hr  (2106) embryo 20-22hr  (1730) embryo 22-24hr  (1937) larva L1  (1367) larva L2  (936) larva L3 12hr old  (686) larva L3 puffstage 1-2  (794) larva L3 puffstage 3-6  (1651) larva L3 puffstage 7-9  (2133) white prepupae new  (2591) white prepupae 12hr  (2213) white prepupae 24hr  (2626) pupae 2d postWPP  (1355) pupae 3d postWPP  (818) pupae 4d postWPP  (701) adult male 01day  (727) adult male 05day  (635) adult male 30day  (622) adult female 01day  (1324) adult female 05day  (1547) adult female 30day  (1361) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2784) embryo 02-04hr  (5407) embryo 04-06hr  (7442) embryo 06-08hr  (8768) embryo 08-10hr  (6781) embryo 10-12hr  (4417) embryo 12-14hr  (4292) embryo 14-16hr  (2610) embryo 16-18hr  (2406) embryo 18-20hr  (2106) embryo 20-22hr  (1730) embryo 22-24hr  (1937) larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6  (1651) larva L3 puffstage 7-9  (2133) white prepupae new  (2591) white prepupae 12hr  (2213) white prepupae 24hr  (2626) pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day  (1547) adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2784 embryo 02-04hr    5407 embryo 04-06hr    7442 embryo 06-08hr    8768 embryo 08-10hr    6781 embryo 10-12hr    4417 embryo 12-14hr    4292 embryo 14-16hr    2610 embryo 16-18hr    2406 embryo 18-20hr    2106 embryo 20-22hr    1730 embryo 22-24hr    1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6    1651 larva L3 puffstage 7-9    2133 white prepupae new    2591 white prepupae 12hr    2213 white prepupae 24hr    2626 pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day    1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2784 embryo 02-04hr    5407 embryo 04-06hr    7442 embryo 06-08hr    8768 embryo 08-10hr    6781 embryo 10-12hr    4417 embryo 12-14hr    4292 embryo 14-16hr    2610 embryo 16-18hr    2406 embryo 18-20hr    2106 embryo 20-22hr    1730 embryo 22-24hr    1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6    1651 larva L3 puffstage 7-9    2133 white prepupae new    2591 white prepupae 12hr    2213 white prepupae 24hr    2626 pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day    1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011764 expression level Developmental Stage   Expression Level embryo 00-02hr    2784 embryo 02-04hr    5407 embryo 04-06hr    7442 embryo 06-08hr    8768 embryo 08-10hr    6781 embryo 10-12hr    4417 embryo 12-14hr    4292 embryo 14-16hr    2610 embryo 16-18hr    2406 embryo 18-20hr    2106 embryo 20-22hr    1730 embryo 22-24hr    1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6    1651 larva L3 puffstage 7-9    2133 white prepupae new    2591 white prepupae 12hr    2213 white prepupae 24hr    2626 pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day    1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2784) embryo 02-04hr  (5407) embryo 04-06hr  (7442) embryo 06-08hr  (8768) embryo 08-10hr  (6781) embryo 10-12hr  (4417) embryo 12-14hr  (4292) embryo 14-16hr  (2610) embryo 16-18hr  (2406) embryo 18-20hr  (2106) embryo 20-22hr  (1730) embryo 22-24hr  (1937) larva L1  (1367) larva L2  (936) larva L3 12hr old  (686) larva L3 puffstage 1-2  (794) larva L3 puffstage 3-6  (1651) larva L3 puffstage 7-9  (2133) white prepupae new  (2591) white prepupae 12hr  (2213) white prepupae 24hr  (2626) pupae 2d postWPP  (1355) pupae 3d postWPP  (818) pupae 4d postWPP  (701) adult male 01day  (727) adult male 05day  (635) adult male 30day  (622) adult female 01day  (1324) adult female 05day  (1547) adult female 30day  (1361) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2784) embryo 02-04hr  (5407) embryo 04-06hr  (7442) embryo 06-08hr  (8768) embryo 08-10hr  (6781) embryo 10-12hr  (4417) embryo 12-14hr  (4292) embryo 14-16hr  (2610) embryo 16-18hr  2406 embryo 18-20hr  2106 embryo 20-22hr  1730 embryo 22-24hr  1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6  1651 larva L3 puffstage 7-9  2133 white prepupae new  (2591) white prepupae 12hr  2213 white prepupae 24hr  (2626) pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day  1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2784 embryo 02-04hr    5407 embryo 04-06hr    7442 embryo 06-08hr    8768 embryo 08-10hr    6781 embryo 10-12hr    4417 embryo 12-14hr    4292 embryo 14-16hr    2610 embryo 16-18hr    2406 embryo 18-20hr    2106 embryo 20-22hr    1730 embryo 22-24hr    1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6    1651 larva L3 puffstage 7-9    2133 white prepupae new    2591 white prepupae 12hr    2213 white prepupae 24hr    2626 pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day    1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2784 embryo 02-04hr    5407 embryo 04-06hr    7442 embryo 06-08hr    8768 embryo 08-10hr    6781 embryo 10-12hr    4417 embryo 12-14hr    4292 embryo 14-16hr    2610 embryo 16-18hr    2406 embryo 18-20hr    2106 embryo 20-22hr    1730 embryo 22-24hr    1937 larva L1    1367 larva L2    936 larva L3 12hr old    686 larva L3 puffstage 1-2    794 larva L3 puffstage 3-6    1651 larva L3 puffstage 7-9    2133 white prepupae new    2591 white prepupae 12hr    2213 white prepupae 24hr    2626 pupae 2d postWPP    1355 pupae 3d postWPP    818 pupae 4d postWPP    701 adult male 01day    727 adult male 05day    635 adult male 30day    622 adult female 01day    1324 adult female 05day    1547 adult female 30day    1361 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011764    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011764 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011764 expression level Tissue   Expression Level Larval Central Nervous System    942.675 Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (942.675) Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary  (616) Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    942.675 Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    942.675 Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011764 expression level Tissue   Expression Level Larval Central Nervous System    942.675 Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (942.675) Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary  616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    942.675 Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    942.675 Larval Midgut    160.7 Larval Hindgut    325.4 Larval Malpighian Tubules    191.7 Larval Fat Body    136.7 Larval Salivary Gland    248.5 Larval Trachea    498.3 Larval Carcass    331.475 Adult Head    219.3 Adult Eye    249.925 Adult Brain    409.5 Adult Thoracic-Abdominal Ganglion    261.4 Adult Crop    381.7 Adult Midgut    140.7 Adult Hindgut    242.8 Adult Malpighian Tubules    88.5 Adult Fat Body    190.9 Adult Salivary Gland    211.5 Adult Heart    172.1 Adult VirginFemale Spermatheca    136.6 Adult InseminatedFemale Spermatheca    196.1 Adult Ovary    616 Adult Testis    62.2 Adult Male Accessory Gland    380.6 Adult Carcass    181.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    219.3   NA  Eye    249.925   NA  Brain    409.5   942.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    261.4   NA  Crop    381.7   160.7  Midgut    140.7   325.4  Hindgut    242.8   191.7  Malpighian Tubules    88.5   136.7  Fat Body    190.9   248.5  Salivary Gland    211.5   NA  Heart    172.1   498.3  Trachea    NA   NA  VirginFemale Spermatheca    136.6   NA  InseminatedFemale Spermatheca    196.1   NA  Ovary    616   NA  Testis    62.2   NA  Male Accessory Gland    380.6   331.475  Carcass    181.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011764 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12223-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD Dsp1GS1115 lethal, with Scer\GAL4c355 Dsp1GS1115 lethal, with Scer\GAL4dpp.blk1 Dsp1GS1115 lethal, with Scer\GAL4hs.2sev Dsp1GS1115 lethal, with Scer\GAL4pnr-MD237 Dsp1GD4269 lethal | partially | recessive Dsp11 viable | poor Dsp11 Sterility Allele fertile | poor Dsp11 sterile | partially | recessive Dsp11 Other Phenotypes Allele flight defective | recessive Dsp11 locomotor behavior defective | recessive Dsp11 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Dsp1EP355 visible, with Scer\GAL4ap-md544 Dsp1EP355 visible, with Scer\GAL4GMR.PF Dsp1EP355 visible | adult stage | homeotic | recessive Dsp11 visible | homeotic Dsp11 wild-type Dsp1274 Phenotype manifest in Allele abdominal 4 ventral denticle belt Dsp11 abdominal 5 ventral denticle belt Dsp11 abdominal sternite bristle | ectopic Dsp11 adult abdominal segment 4 Dsp11 adult abdominal segment 5 | ectopic Dsp11 adult abdominal segment 6 Dsp11 adult thorax | dorsal, with Scer\GAL4ap-md544 Dsp1EP355 anterior fascicle & synapse, with Scer\GAL4elav-C155 Dsp1EP355 egg Dsp11 embryonic/first instar larval cuticle Dsp11 eye, with Scer\GAL4GMR.PF Dsp1EP355 haltere Dsp11 intersegmental nerve, with Scer\GAL4elav-C155 Dsp1EP355 metathoracic laterotergite Dsp11 metathoracic leg | ectopic Dsp11 metathoracic segment | anterior compartment Dsp11 prothoracic leg Dsp11 scutellum, with Scer\GAL4ap-md544 Dsp1EP355 scutum | ectopic Dsp11 sex comb Dsp11 wing, with Scer\GAL4ap-md544 Dsp1EP355 wing | ectopic Dsp11
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Dsp1 Class Mutagen Stocks Known lesion Dsp1d07366 P-element activity 1 -- Dsp1EP355 P-element activity 1 Yes Dsp1f00014 1 -- Dsp1f02356 piggyBac transposase 1 -- Dsp1NP4141 1 -- Dsp11 loss of function allele Delta2-3 P-element activity 0 Yes Dsp1274 Delta2-3 0 Yes Dsp1CPTI002844 piggyBac transposase 0 Yes Dsp1GS1115 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dsp1 Class Mutagen Stocks Known lesion Dsp1GD4269 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsp1JF02732 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsp1KK107579 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dsp1Scer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Dsp1Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)19 (Decoville et al., 2001)
Duplicated in	Dp(1;Y)shi+3 (Decoville et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4269} NA P{KK107579} NA P{TRiP.JF02732} NA P{UAS-Dsp1.D} NA P{UASp-Dsp1.3xFLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Dsp1EP355 NA P{GSV1}Dsp1GS1115 NA P{Mae-UAS.6.11}B2017B2017 NA P{XP}Dsp1d07366 NA miscellaneous insertions ?{}Dsp11 NA P{}Dsp1274 NA PBac{CPTI-un}Dsp1CPTI002844 NA PBac{WH}Dsp1f00014 NA PBac{WH}Dsp1f02356 NA insertion of enhancer trap binary system P{GawB}Dsp1NP4141 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
DNA bending activity inferred from direct assay (Janke et al., 2003) DNA binding inferred from direct assay (Lehming et al., 1994) TBP-class protein binding inferred from physical interaction with Tbp (Kirov et al., 1996) transcription factor binding inferred from physical interaction with dl (Decoville et al., 2000)
Biological Process
CV term Evidence References
chromatin remodeling inferred from mutant phenotype (Decoville et al., 2001) developmental process inferred from mutant phenotype (Mosrin-Huaman et al., 1998) leg disc development inferred from mutant phenotype (Ragab et al., 2006) negative regulation of antimicrobial humoral response inferred from genetic interaction with Rel (Kim et al., 2007) inferred from mutant phenotype (Kim et al., 2007) negative regulation of RNA polymerase II transcriptional preinitiation complex assembly inferred from direct assay (Kirov et al., 1996) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Lehming et al., 1994, Lehming et al., 1998) inferred from mutant phenotype (Decoville et al., 2000) positive regulation of DNA binding inferred from direct assay (Lehming et al., 1994, Decoville et al., 2000) segment specification inferred from mutant phenotype (Decoville et al., 2001)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Mosrin-Huaman et al., 1998) polytene chromosome inferred from direct assay (Lamiable et al., 2010)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred by curator from GO:0003677|GO:0000122 (Lehming et al., 1994)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dsp1 allele Gene References Dsp11 Antp (Decoville et al., 2001) ash1 (Decoville et al., 2001) Pc (Decoville et al., 2001) Scr (Decoville et al., 2001) trx (Decoville et al., 2001) Ubx (Decoville et al., 2001) Dsp1EP355 btl (Zhu et al., 2005) pnr (Pena-Rangel et al., 2002) Rac1 (Zhu et al., 2005) Dsp1Scer\UAS.cDa Pc (Decoville et al., 2001) unspecified grim (Mueller et al., 2005) H (Mueller et al., 2005) HmgD (Ragab et al., 2006) HmgZ (Ragab et al., 2006) p53 (Mueller et al., 2005) rpr (Mueller et al., 2005) W (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72866 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011764 DroID - A comprehensive database of gene and protein interactions. • FBgn0011764 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117294
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19115 Dere\GG17955 Dgri\GH12282 Dmoj\GI10980 Dper\GL15829 Dpse\GA11488 Dsim\GD17278 Dvir\GJ19445 Dwil\GK25058 Dyak\GE17263
Curated drosophilid orthologs	Dpse\GA11488
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011380-PA Aedes aegypti (mosquito) AGAP000005-PA Anopheles gambiae (mosquito) XP_001121384.1 Apis mellifera (honey bee) XP_001944154.1 Acyrthosiphon pisum (pea aphid) At4g11080.1 Arabidopsis thaliana (wall cress) 57556 Branchiostoma floridae (lancelet) BGIBMGA001132-PA Bombyx mori (silk worm) ENSBTAP00000019791 Bos taurus (bovine) ENSBTAP00000020096 Bos taurus (bovine) ENSBTAP00000024094 Bos taurus (bovine) CN09990 Caenorhabditis brenneri (small nematode) CBP03568 Caenorhabditis briggsae (nematode) ENSCAFP00000009862 Canis familiaris (dog) CAGL0L02013g Candida glabrata (haploid yeast) ENSCINP00000008399 Ciona intestinalis (sea squirt) CPIJ014043 Culex pipens (mosquito) ENSCPOP00000020089 Cavia porcellus (guinea pig) 151215 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000000612 Ciona savignyi (sedentary tunicate) 158220 Capitella spl (polychaete worm) DDB0220651 Dictyostelium discoideum (amoeba) 232871 Daphnia pulex (daphnia) ENSDARP00000040975 Danio rerio (zebra fish) ENSECAP00000006518 Equus caballus (horse) ENSGACP00000015140 Gymnopilus aculeatus (mushroom) ENSGALP00000027541 Gallus gallus (chicken) 157878 Hypsipyla robusta (cedar shoot borer) ENSP00000345347 Homo sapiens (human) ISCW017350-PA Ixodes scapularis (deer tick) KLLA0E18481g Kluyveromyces lactis (yeast) 200052 Lottia gigantea (owl limpet) LmjF29.0850 Leishmania major (virus) 34324 Monocosta brevicollis (choanoflagellate) ENSMODP00000004305 Monodelphis domestica (gray opossum) ENSMODP00000010935 Monodelphis domestica (gray opossum) ENSMMUP00000004251 Macaca mulatta (rhesus monkey) ENSMMUP00000038937 Macaca mulatta (rhesus monkey) ENSMUSP00000082625 Mus musculus (house mouse) ENSMUSP00000082682 Mus musculus (house mouse) XP_001605958.1 Nasonia vitripennis (wasp) ENSOANP00000018433 Ornithorynchus anatinus (platypus) ENSORLP00000004224 Oryzias latipes (japanese killifish) 24540 Ostreococcus tauri (green alga) 210318 Physcomitrella patens (moss) ENSPPYP00000006318 Pongo pygmaeus (orangutan) 73033 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000009794 Pan troglodytes (chimpanzee) ENSRNOP00000040874 Rattus norvegicus (norway rat) ENSRNOP00000044451 Rattus norvegicus (norway rat) Smp_000980 Schistosoma mansoni (trematode parasite) XP_001176404.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001176807.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001178542.1 Strongylocentrotus purpuratus (purple sea urchin) 56397 Trichoplax adhaerens (metazoa) XP_973934.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012801 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011525 Takifugu rubripes (pufferfish Takifugu) 97090.m00120 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000041556 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12629 NV15664 LH12822 ISCW017350 FBgn0234741 FBgn0227017 FBgn0206588 FBgn0188840 JGI_V11_306496 JGI_V11_232871 FBgn0071539 FBgn0153433 FBgn0133743 FBgn0119761 FBgn0110175 FBgn0096126 CPIJ014043 BGIBMGA001132 ACYPI007949 GB13747 AGAP000005 AAEL011380 PHUM006290 GLEAN_07692
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	17270 w1118 P{EP}Dsp1EP355 31960 y1 v1; P{TRiP.JF02732}attP2
Harvard	- P{XP}Dsp1d07366 - PBac{WH}Dsp1f00014 - PBac{WH}Dsp1f02356
Kyoto	113403 w* P{GawB}Dsp1NP4141 / FM7c
VDRC	v101327 P{KK107579}VIE-260B v41029 w1118; P{GD4269}v41029
Genomic Clones ( 2 )
	BACR06P10 BACR13G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 235 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM02110 RE09522 RE44118 SD05379
Other clones	DPiM_GM02110
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10190 GM29307 LD09221 LD15831 RE02519 RE07683 RE11030 RE15474 RE20020 RE20050 RE22211 RE25875 RE27434 RE32392 RE36054 RE41138 RE53315 RE53986 RE56640 RE65070 RE65405 RE67534 RE67783 RE71712 RE73482
Other clones	7893 45020 58677 59780 63198 65193 65943 71361 77145 125610 144661 157077 160217 160670 210988.1 211266.2 214253.15 214439.47 214505.29 214511.37 214545.36 214571.42 281931 283493 CK01.16A.E4 CK01.29D.A12 CK01.41C.A10 CK01.55D.C2 CK01.82D.F4 CK01.88A.G5 CK01.95A.E3 CK01.104D.C3 Dmel_dig_005675_0669_0411 Dmel_dig_010107_0682_0887 Dmel_neb_003872_0877_3633 Dmel_neb_008627_0633_0939 Dmel_neb_009672_0901_3053 Dmel_neb_010759_0379_1522 Dmel_neb_011579_0840_2913 Dmel_neb_012339_0160_2631 Dmel_neb_015448_0834_1363 EC13383 EK026327 EK031916 EK035335 EK038521 EK044641 EK045341 EK050315 EK063803 EK066154 EK069208 EK069427 EK073914 EK076308 EK087710 EK094710 EK130611 EK130944 EK131919 EK134616 EK160443 EK163741 EK180822 EK181461 EK186028 EK188752 EK191741 EK196513 EK199232 EK201507 EK211654 EK214204 EK215406 EK215425 EK225217 EK234935 EK237303 EK247759 EK250840 EK259842 EK262928 EK263129 EK264452 EK290153 EK299307 EK307201 EK307462 EP04531 EP10039 EP11828 EP12231 EP21036 EP22218 FGM229B01 RP01428 RP001000721 RP001000958 RP001001932 RP001002191 RP001002551 RP001003503 RP001003733 RP001005406 RP001005567 RP001005575 RP001005683 RP001006415 RP001006723 RP001006917 RP001007097 RP001007875 RP001008810 RP001009577 RP001009633 RP001009662 RP001010107 RP001011132 RP001011923 RP001012895 RP001014317 RP001014784 RP001015687 RP001015993 RP001016168 RP001016182 RP001016219 RP001016416 RP001017602 RP001017773 RP001017887 RP001018165 RP001018484 RP001018960 RP001019090 RP001019368 RP001019415 RP001021877 RP001022122 RP001022165 RP001023312 RP001023427 RP001023798 RP001023996 RP001024418 RP001024911 RP001027762 RP001028911 RP001028952 RP001030157 RP001030653 RP001030672 RP001031158 RP001031329 RP001031473 RP001031721 RP001031967 RP001033373 RP001033723 RP001033873 RP001036613 RP001036699 RP001036874 RP001037414 RP001037788 RP001038605 RP001038887 RP001039125 RP001039738 RP001039774 RP001039950 RP001040265 RP001040338 RP001040626 RP001041982 RP001042125 RP001042398 RP001042602 RP001043532 RP001043586 RP001044355 RP001045040 RP001046548 RP001046810 RP001046842 RP001046881 RP001047175 RP001049432 RP001049735 RP001049744 RP001050675 RP001051342 RP001051846 RP001052359 RP001052550 RP001053166 RP001053202 RP001053569 RP001054710 RP001054990 RP001055630 RP001055920 RP001056618 RP004010522 RP004557545
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011764 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117294
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dsp1 Hmg14D (FlyBase, 1996-)
Additional comments	"bss" stated to correspond to "Dsp1". (Reynolds and Tanouye, 1998) Source for merge of Dsp1 Hmg14D was sequence comparison (date:000202). (FlyBase, 1996-)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Dsp1 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) Dsp1 may act as a chromatin remodeling factor. (Decoville et al., 2001) Loss of Dsp1 function causes homeotic transformations resembling those associated with loss of function mutations in Scr, Ubx and Abd-B. (Decoville et al., 2001) Dsp1 protein binds cooperatively to Rel sites on DNA with NF-κΒ, the p50 subunit of the NF-κΒ heterodimer and with the Rel domain of dl. This cooperativity is unaffected by the presence of a negative regulatory element. Dif does not show high cooperative DNA binding with Dsp1 protein. dl can activate transcription from zen and twi promoters, and additional Dsp1 inhibits the zen activation and increases the twi activation. (Brickman et al., 1999) Dsp1 protein can act as a potent transcriptional repressor for multiple activator families in vitro and in transfection studies. Dsp1 represses activated transcription by interfering with the binding of TFIIA, a general transcription factor implicated in activated transcription pathways. (Kirov et al., 1996) Dsp1 can convert dl from a transcriptional activator to repressor. This effect requires the sequence termed a negative regulatory element (NRE) found adjacent to the dl binding sites in the zen promoter. (Lehming et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080715 NM_167502 NM_167503 NM_167504 NM_206762 NM_001144731 RefSeq (Proteins) • NP_542446 NP_727959 NP_727960 NP_727961 NP_996485 NP_001138203 DDBJ / EMBL / GenBank • AA695083 AAA50238 AAF48594 AAL28389 AAN09394 AAN09395 AAN09396 AAS65386 ACL82935 AQ025322 AW941922 AY060841 CAA57212 CAA61938 CZ475687 CZ484859 U13881 X81456 X89811 Entrez Gene - A searchable database of RefSeq genes. • 117294 UniProtKB/Swiss-Prot • Q24537
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • HMG box A DNA-binding domain, conserved site (IPR017967) High mobility group, HMG1/HMG2, subgroup (IPR000135) High mobility group, HMG1/HMG2 (IPR000910) High mobility group, superfamily (IPR009071)
Linkouts
	BioGRID - A database of protein and genetic interactions • 72866 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011764 DroID - A comprehensive database of gene and protein interactions. • FBgn0011764 DRSC - Results from RNAi screens. • FBgn0011764 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011764 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12223-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011764 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 92302 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117294 InParanoid A subset of ortholog calls from InParanoid. • AAEL011380-PA Aedes aegypti (mosquito) AGAP000005-PA Anopheles gambiae (mosquito) XP_001121384.1 Apis mellifera (honey bee) XP_001944154.1 Acyrthosiphon pisum (pea aphid) At4g11080.1 Arabidopsis thaliana (wall cress) 57556 Branchiostoma floridae (lancelet) BGIBMGA001132-PA Bombyx mori (silk worm) ENSBTAP00000019791 Bos taurus (bovine) ENSBTAP00000020096 Bos taurus (bovine) ENSBTAP00000024094 Bos taurus (bovine) CN09990 Caenorhabditis brenneri (small nematode) CBP03568 Caenorhabditis briggsae (nematode) ENSCAFP00000009862 Canis familiaris (dog) CAGL0L02013g Candida glabrata (haploid yeast) ENSCINP00000008399 Ciona intestinalis (sea squirt) CPIJ014043 Culex pipens (mosquito) ENSCPOP00000020089 Cavia porcellus (guinea pig) 151215 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000000612 Ciona savignyi (sedentary tunicate) 158220 Capitella spl (polychaete worm) DDB0220651 Dictyostelium discoideum (amoeba) 232871 Daphnia pulex (daphnia) ENSDARP00000040975 Danio rerio (zebra fish) ENSECAP00000006518 Equus caballus (horse) ENSGACP00000015140 Gymnopilus aculeatus (mushroom) ENSGALP00000027541 Gallus gallus (chicken) 157878 Hypsipyla robusta (cedar shoot borer) ENSP00000345347 Homo sapiens (human) ISCW017350-PA Ixodes scapularis (deer tick) KLLA0E18481g Kluyveromyces lactis (yeast) 200052 Lottia gigantea (owl limpet) LmjF29.0850 Leishmania major (virus) 34324 Monocosta brevicollis (choanoflagellate) ENSMODP00000004305 Monodelphis domestica (gray opossum) ENSMODP00000010935 Monodelphis domestica (gray opossum) ENSMMUP00000004251 Macaca mulatta (rhesus monkey) ENSMMUP00000038937 Macaca mulatta (rhesus monkey) ENSMUSP00000082625 Mus musculus (house mouse) ENSMUSP00000082682 Mus musculus (house mouse) XP_001605958.1 Nasonia vitripennis (wasp) ENSOANP00000018433 Ornithorynchus anatinus (platypus) ENSORLP00000004224 Oryzias latipes (japanese killifish) 24540 Ostreococcus tauri (green alga) 210318 Physcomitrella patens (moss) ENSPPYP00000006318 Pongo pygmaeus (orangutan) 73033 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000009794 Pan troglodytes (chimpanzee) ENSRNOP00000040874 Rattus norvegicus (norway rat) ENSRNOP00000044451 Rattus norvegicus (norway rat) Smp_000980 Schistosoma mansoni (trematode parasite) XP_001176404.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001176807.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001178542.1 Strongylocentrotus purpuratus (purple sea urchin) 56397 Trichoplax adhaerens (metazoa) XP_973934.2 Tribolium castaneum (red flour beetle) ENSTNIP00000012801 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011525 Takifugu rubripes (pufferfish Takifugu) 97090.m00120 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000041556 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117294 modMine - Data generated by the modENCODE project. • FBgn0011764 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12629 NV15664 LH12822 ISCW017350 FBgn0234741 FBgn0227017 FBgn0206588 FBgn0188840 JGI_V11_306496 JGI_V11_232871 FBgn0071539 FBgn0153433 FBgn0133743 FBgn0119761 FBgn0110175 FBgn0096126 CPIJ014043 BGIBMGA001132 ACYPI007949 GB13747 AGAP000005 AAEL011380 PHUM006290 GLEAN_07692
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG12223 (Kraut et al., 2001, Kraut et al., 2001, Whitfield, 2000.5.8, Quinones-Coello, 2007, Grieder et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009) Dsp1 (Cao et al., 2008, Brown et al., 2005, Schuettengruber, 2006, Legube et al., 2006, Sessa and Bianchi, 2007, Quinones-Coello, 2007, Grieder et al., 2007, Ringrose and Paro, 2007, Kim et al., 2007, Cardoso et al., 2006, Yatsu et al., 2008, Pruteanu-Malinici et al., 2011, Cunha et al., 2010, Huen and Russell, 2010) DSP1 (Bianchi and Agresti, 2005, Dejardin et al., 2005, Rappailes et al., 2002, Govind, 1999, Lehming, 1994.8.21, Decoville et al., 1999, Mosrin-Huaman et al., 1998, Ogbourne and Antalis, 1998, Rorth et al., 1998, Ip and Hemavathy, 1997, Kirov et al., 1996, Canaple et al., 1997, Ip, 1995, Schwartz and Pirrotta, 2007, Decoville et al., 2007, Hauenschild et al., 2008, Qi et al., 2007, Schuettengruber et al., 2009, Shevelyov et al., 2009, Janke et al., 2003, de Wit et al., 2008, van Steensel et al., 2010, Filion et al., 2010, Lamiable et al., 2010) dsp1 (Dejardin et al., 2005, Decoville et al., 2001, Decoville et al., 2001, LOCKER and DECOVILLE, 2006, Daulny et al., 2003, Muller and Kassis, 2006, Salvaing et al., 2006) Hmg14D   ssrp2 (Locker, 1995.7.19) Ssrp2
Name Synonym	Dorsal switch protein 1 (Lehming et al., 1994, ) Dorsal Switch Protein 1 (Brown et al., 2005, Lamiable et al., 2010) Dorsal switch protein-1 (Huen and Russell, 2010) Structure specific recognition protein 2
Secondary FlyBase IDs
	FBgn0015237 FBgn0015301
References ( 80 )
Generate a list of	All references relating to this gene ( 80 )
List References by type	Research paper  ( 40 ) Supplementary material  ( 6 ) Review  ( 9 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 6 )
	Pruteanu-Malinici et al., 2011, PLoS Comput. Biol. 7(7): e1002098 Automatic Annotation of Spatial Expression Patterns via Sparse Bayesian Factor Models. [FBrf0214618] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Huen and Russell, 2010, BMC Bioinformatics 11: 359 On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence. [FBrf0214212] Lamiable et al., 2010, genesis 48(4): 244--253 Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos. [FBrf0210563] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...