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FB2021_04, released August 17, 2021

Gene: Dmel\E2f1

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General Information
Symbol
Dmel\E2f1
Species
D. melanogaster
Name
E2F transcription factor 1
Annotation Symbol
CG6376
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011766
Gene Model Status
Current
Stock Availability
36 publicly available
Gene Summary
Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg. (UniProt, Q27368)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

E2F, dE2F1, dE2F, E(var)3-93E, drosE2F1

Key Links
Genomic Location
Cytogenetic map
93E9-93F1
Sequence location
3R:21,620,304..21,660,871 [-]
Recombination map
3-72
RefSeq locus
NT_033777 REGION:21620304..21660871
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (29 terms)
Molecular Function (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
enables DNA binding
inferred from direct assay
(Ohtani and Nevins, 1994)
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Stevaux et al., 2002)
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from physical interaction with FLYBASE:Dp; FB:FBgn0011763
(Dynlacht et al., 1994)
enables DNA-binding transcription factor activity
inferred from direct assay
(Ohtani and Nevins, 1994)
enables DNA-binding transcription repressor activity, RNA polymerase II-specific
inferred from direct assay
(Zhang et al., 2017)
enables protein binding
inferred from physical interaction with FLYBASE:l(3)mbt; FB:FBgn0002441
(Lu et al., 2007)
inferred from physical interaction with FLYBASE:dom; FB:FBgn0020306
(Lu et al., 2007)
inferred from physical interaction with FLYBASE:Rbf; FB:FBgn0015799
(Du et al., 1996)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from mutant phenotype
(Kim et al., 2018)
inferred from direct assay
(Lee et al., 2012)
contributes_to sequence-specific DNA binding
inferred from physical interaction with FLYBASE:Dp; FB:FBgn0011763
(Sawado et al., 1998)
enables transcription factor binding
inferred from physical interaction with FLYBASE:Dp; FB:FBgn0011763
(Dynlacht et al., 1994)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from sequence or structural similarity with HGNC:3113
(Ohtani and Nevins, 1994)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR032198
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000249624
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (15 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in DNA endoreduplication
inferred from mutant phenotype
(Weng et al., 2003)
inferred from genetic interaction with FLYBASE:CycE; FB:FBgn0010382
(Weng et al., 2003)
involved_in larval lymph gland hemopoiesis
inferred from mutant phenotype
(Mondal et al., 2014)
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Zhang et al., 2017, Sawado et al., 1998)
involved_in positive regulation of apoptotic process
inferred from mutant phenotype
(Zhang et al., 2017)
involved_in positive regulation of DNA endoreduplication
inferred from mutant phenotype
(Kim et al., 2018)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Lu et al., 2007)
involved_in positive regulation of nurse cell apoptotic process
inferred from mutant phenotype
(Royzman et al., 2002)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Sawado et al., 1998, Ohtani and Nevins, 1994)
involved_in regulation of execution phase of apoptosis
inferred from mutant phenotype
(Bhaskar et al., 2014)
involved_in regulation of gene expression
inferred from mutant phenotype
(Kim et al., 2018)
involved_in regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
involved_in ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in eggshell chorion gene amplification
traceable author statement
(Lee and Orr-Weaver, 2003, McNairn and Gilbert, 2003)
involved_in G1/S transition of mitotic cell cycle
traceable author statement
(Lee and Orr-Weaver, 2003)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000249624
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ohtani and Nevins, 1994)
part_of Rb-E2F complex
inferred from direct assay
(Stevaux et al., 2002, Du et al., 1996)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of RNA polymerase II transcription regulator complex
inferred from biological aspect of ancestor with PANTHER:PTN000249624
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the E2F/DP family. (Q27368)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
E2F TRANSCRIPTION FACTORS -
The E2F/DP family of transcription factors are sequence-specific DNA-binding proteins that regulate transcription. The functional E2F are transcriptional heterodimers composed of two subunits, E2F and DP. (Adapted from FBrf0128583).
Protein Function (UniProtKB)
Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg.
(UniProt, Q27368)
Summary (Interactive Fly)

positively regulates genes involved in the S (DNA synthesis) phase of the cell cycle - alternate transcripts are necessary for maintenance of cell cycle exit during development - required during late myogenesis to directly control the expression of a set of muscle-specific genes

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\E2f1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.47

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
E2f1-RA
FBtr0084119
NM_079713
3913
805
E2f1-RB
FBtr0084117
NM_169961
3150
805
E2f1-RC
FBtr0084118
NM_169962
4778
805
E2f1-RD
FBtr0334678
NM_001275880
3581
821
E2f1-RE
FBtr0345217
NM_001300525
4234
821
E2f1-RF
FBtr0346157
NM_001300526
4653
805
Additional Transcript Data and Comments
Reported size (kB)

4.7 (northern blot)

(Sawado et al., 1998)

4.5 (longest cDNA)

(Dynlacht et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
E2f1-PA
FBpp0083518
87.5
805
6.64
NP_524437
AAF55904
E2f1-PB
FBpp0083516
87.5
805
6.64
NP_732646
AAN13878
E2f1-PC
FBpp0083517
87.5
805
6.64
NP_732647
AAN13879
E2f1-PD
FBpp0306739
89.3
821
6.72
NP_001262809
AGB96189
E2f1-PE
FBpp0311412
89.3
821
6.72
NP_001287454
AHN57453
E2f1-PF
FBpp0311985
87.5
805
6.64
NP_001287455
AHN57454
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

805 aa isoforms: E2f1-PA, E2f1-PB, E2f1-PC, E2f1-PF
821 aa isoforms: E2f1-PD, E2f1-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

805 (aa)

(Dynlacht et al., 1994)

805 (aa); 88 (kD predicted)

(Ohtani and Nevins, 1994)
Comments

E2f2 protein requires Dp protein for binding to the E2f recognition sites of the adenovirus E2 promoter. E2f protein does not require Dp protein for binding the same site, but binding is enhanced in the presence of Dp protein. E2f2 binds to one of two E2f recognition sites in the mus209 gene promoter. Unlike the transcription activator E2f, E2f2 acts as a repressor of expression from the mus209 promoter.

(Sawado et al., 1998)

Cotransfection assays in S2 cells were used to demonstrate that E2f protein and Dp protein form a heteromeric complex and cooperate to give sequence-specific DNA binding and transcriptional activation. Deletion mutants of E2f protein were made to identify a region of E2f protein necessary for interaction with Dp protein.

(Dynlacht et al., 1994)

E2f protein expressed in bacteria was shown to have DNA-binding activity and to bind specifically to E2f recognition sequences. In S2 cells, E2f protein stimulates transcription and the activation is dependent on functional E2f binding sites. The transcription activation function was mapped to the C-terminal portion of the E2f protein between amino acids 560 and 769. Finally, E2f protein recognition sequences were found within the promoter of the DNA polymerase alpha gene.

(Ohtani and Nevins, 1994)
External Data
Subunit Structure (UniProtKB)

Heterodimer of E2f and Dp. Cooperates to give sequence-specific DNA binding and optimal trans-activation. Interacts with PCNA.

(UniProt, Q27368)
Post Translational Modification

Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase. Ubiquitination by the DCX(DTL) complex is essential for cell cycle control and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation.

(UniProt, Q27368)
Domain

The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.

(UniProt, Q27368)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\E2f1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Duronio et al., 1995)
neuroblast
(Duronio et al., 1995)
embryonic stage 1
organism | ubiquitous
(Seum et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
(Duronio et al., 1995)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
organism | ubiquitous
(Hao et al., 1995)
embryonic stage 7
ventral furrow
(Seum et al., 1996)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 8 -- 11
mesoderm
(Seum et al., 1996)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 11
neuroblast
(Seum et al., 1996)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 10 -- 17
organism | ubiquitous
(Duronio et al., 1995)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic central brain surface glia
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
lateral cord surface glial cell
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 12
presumptive embryonic/larval central nervous system | restricted
(Hao et al., 1995)
embryonic stage 12 -- 17
embryonic brain
(Hao et al., 1995)
embryonic stage 13
embryonic/larval anterior midgut
(Seum et al., 1996)
embryonic/larval posterior midgut
(Seum et al., 1996)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic midgut chamber
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
gastric caecum
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 16
embryonic/larval midgut
(Seum et al., 1996)
embryonic/larval foregut
(Seum et al., 1996)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Sawado et al., 1998)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ohtani and Nevins, 1994)
part_of Rb-E2F complex
inferred from direct assay
(Stevaux et al., 2002, Du et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\E2f1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 56 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 41 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of E2f1
Transgenic constructs containing regulatory region of E2f1
Aberrations (Deficiencies and Duplications) ( 6 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL430A
lethal, with Scer\GAL432B
lethal, with Scer\GAL434B
lethal, with Scer\GAL471B
lethal, with Scer\GAL4179Y
lethal, with Scer\GAL41854
lethal, with Scer\GAL43735
lethal, with Scer\GAL44935
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4ap-md544
lethal, with Scer\GAL4arm.PS
lethal, with Scer\GAL4C23
lethal, with Scer\GAL4c323a
lethal, with Scer\GAL4Cy6
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4Dll-md23
lethal, with Scer\GAL4dpp.blk1
lethal, with Scer\GAL4en.PU
lethal, with Scer\GAL4ey.PH
lethal, with Scer\GAL4h-H10
lethal, with Scer\GAL4how-24B
lethal, with Scer\GAL4sev.EP
lethal, with Scer\GAL4T80
lethal, with Scer\GAL4tsh-md621
lethal, with Scer\GAL4twi.2PE
lethal, with Scer\GAL4αTub84B.PL
lethal (with E2f191)
lethal (with E2f107172)
lethal | recessive
lethal - all die before end of larval stage (with E2f191)
lethal - all die before end of larval stage (with E2f1rM729)
lethal - all die before end of second instar larval stage (with Df(3R)Exel6186)
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4arm.PS
partially lethal - majority die, with Scer\GAL4en-e16E
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die, with Scer\GAL4sca-T3
partially lethal - majority die (with Df(3R)Exel6186)
partially lethal - majority die (with E2f1mir-11-KO.w+)
partially lethal - majority die (with E2f1unspecified)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
viable (with E2f191)
viable (with E2f1i2)
viable (with E2f1mir-11-R.w-)
viable (with E2f1unspecified)
Sterility
Allele
female fertile
female semi-sterile | recessive
female sterile
female sterile, with E2f191
female sterile, with E2f1hs.PD
female sterile | recessive
fertile
male fertile
Other Phenotypes
Allele
abnormal behavior
abnormal cell adhesion | somatic clone | third instar larval stage
abnormal cell death
abnormal cell death | third instar larval stage, with Scer\GAL4en-e16E
abnormal cell death | third instar larval stage, with Scer\GAL4GMR.PU
abnormal cell shape | somatic clone | third instar larval stage
abnormal developmental rate (with E2f191)
abnormal developmental rate (with E2f1rM729)
abnormal developmental rate | larval stage
abnormal developmental rate | larval stage (with E2f191)
abnormal developmental rate | larval stage (with E2f1rM729)
abnormal endomitotic cell cycle
abnormal mitotic cell cycle, with Scer\GAL4en-e16E
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4c768
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4en-e16E
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4GMR.PU
abnormal neuroanatomy
abnormal neuroanatomy | homeotic, with Scer\GAL4sca-537.4
abnormal size | adult stage | female (with Df(3R)Exel6186)
abnormal size | larval stage (with Df(3R)Exel6186)
abnormal size | larval stage (with E2f191)
abnormal size | larval stage (with E2f1rM729)
abnormal size | oogenesis | oogenesis
abnormal size | somatic clone | third instar larval stage
decreased cell death (with E2f107172)
decreased cell death (with E2f1i1)
decreased cell size, with Scer\GAL4en-e16E
decreased cell size | somatic clone | third instar larval stage
decreased occurrence of cell division | larval stage (with E2f191)
decreased occurrence of cell division | larval stage (with E2f1rM729)
enhancer of variegation, with In(1)wm4
enhancer of variegation | dominant, with Dp1187-8-23, In(1)wm4h
enhancer of variegation | dominant, with In(1)wm4h
increased cell death, with Scer\GAL4en-e16E
increased cell death | heat sensitive, with Scer\GAL4ptc-559.1
increased cell death | larval stage, with Scer\GAL4GMR.PU
increased cell number, with Scer\GAL4sca-537.4
increased cell size | somatic clone
increased occurrence of cell division | embryonic stage, with Scer\GAL4arm.PS
increased occurrence of cell division | embryonic stage (with Df(3R)e-D7)
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PU
increased occurrence of cell division | larval stage (with Df(3R)Exel6186)
increased occurrence of cell division | third instar larval stage, with Scer\GAL4arm.PS
melanotic mass phenotype
non-enhancer of variegation | dominant, with P{hsp26-pt-T}39C-12
non-enhancer of variegation | dominant, with P{hsp26-pt-T}39C-42
non-enhancer of variegation | dominant, with P{hsp26-pt-T}118E-3
non-enhancer of variegation | dominant, with P{hsp26-pt-T}118E-10
non-enhancer of variegation | dominant, with P{hsp26-pt-T}118E-19
non-enhancer of variegation | dominant, with P{hsp26-pt-T}118E-25-5
non-enhancer of variegation | dominant, with P{hsp26-pt-T}Abcd139C-34
non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12
non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42
non-suppressor of variegation | dominant, with P{hsp26-pt-T}118E-3
non-suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10
non-suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19
non-suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5
non-suppressor of variegation | dominant, with P{hsp26-pt-T}Abcd139C-34
radiation resistant | cell non-autonomous, with Scer\GAL4ptc-559.1
radiation resistant | cell non-autonomous, with Scer\GAL4ptc-559.1, Scer\GAL80αTub84B.PL
radiation resistant | maternal effect
some die during larval stage (with E2f191)
some die during larval stage (with E2f1rM729)
some die during P-stage
some die during P-stage (with Df(3R)Exel6186)
some die during pupal stage, with Scer\GAL4pnr-MD237
suppressor of variegation | dominant, with In(1)wm4h
visible
visible, with Scer\GAL4- :
visible, with E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
visible, with E2f1i1, Scer\GAL4GMR.PU
visible, with Scer\GAL4Act88F.PD
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4I-76-D
visible, with Scer\GAL4nos.PG
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4sca-T3
visible, with Scer\GAL4wg.PM
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4nub.PK
visible | recessive
wild-type
Phenotype manifest in
Allele
1st posterior cell, with Scer\GAL4ptc-559.1
abdomen, with Scer\GAL4ptc-559.1
adherens junction | somatic clone | third instar larval stage
adult pericardial cell, with Scer\GAL4Ugt36A1.PK
antenna, with Scer\GAL4- :
antenna, with Scer\GAL4I-76-D
anterior midgut primordium, with Scer\GAL4arm.PS
anterior midgut primordium | embryonic stage (with Df(3R)e-D7)
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax Ap4
central nervous system
chordotonal organ
dorsal appendage (with E2f107172)
dorsal appendage (with E2f1i2)
egg
egg (with E2f107172)
egg (with E2f1i2)
egg chorion
embryonic/larval lymph gland, with Scer\GAL4HCH.Hand, Scer\GAL4Hml.Δ
embryonic/larval optic lobe
embryonic/larval optic lobe | larval stage (with E2f191)
embryonic/larval optic lobe | larval stage (with E2f1rM729)
embryonic/larval salivary gland | larval stage (with Df(3R)Exel6186)
embryonic/larval tracheal stalk cell | somatic clone | third instar larval stage
embryonic thorax & neuron
epidermis
eye
eye, with Scer\GAL4- :
eye, with E2f191
eye, with E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
eye, with E2f1hs.PD
eye, with E2f1i1, Scer\GAL4GMR.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4I-76-D
eye-antennal disc
eye disc
eye disc, with Scer\GAL4GMR.PU
eye disc & mitotic cell cycle
eye disc | larval stage (with E2f191)
eye disc | larval stage (with E2f1rM729)
eye disc | somatic clone
eye disc posterior compartment (with Df(3R)Exel6186)
eye disc posterior to the morphogenetic furrow, with Scer\GAL4GMR.PU
eye photoreceptor cell
fat cell | third instar larval stage, with Scer\GAL4Cg.PA
fertilized egg | maternal effect
follicle cell
follicle stem cell | somatic clone
heterochromatin & nurse cell, with E2f191
heterochromatin & nurse cell, with E2f1hs.PD
heterochromatin & nurse cell (with Df(3R)e-BS2)
imaginal disc (with E2f191)
imaginal disc (with E2f1rM729)
interommatidial bristle
interommatidial bristle | ectopic
larval optic anlage | somatic clone
larval outer optic anlage, with Scer\GAL4c768
macrochaeta
macrochaeta, with Scer\GAL4nos.PG
macrochaeta, with Scer\GAL4sca-T3
mesothoracic tergum, with Scer\GAL4pnr-MD237
microtubule | third instar larval stage, with Scer\GAL4Cg.PA
midgut primordium & S phase
neuroblast
neuroblast NB6-4
neuroblast NB6-4 of abdomen, with Scer\GAL4sca-537.4
neuroblast NB6-4 of thorax | ectopic, with Scer\GAL4sca-537.4
nuclear chromosome & nurse cell (with Df(3R)e-BS2)
nuclear membrane & nurse cell (with Df(3R)e-BS2)
nucleus | larval stage (with Df(3R)Exel6186)
nucleus | somatic clone | third instar larval stage
nucleus | third instar larval stage, with Scer\GAL4Cg.PA
nurse cell
nurse cell (with Df(3R)e-BS2)
nurse cell (with E2f107172)
nurse cell (with E2f1i1)
ommatidium
ommatidium, with Scer\GAL4GMR.PU
oocyte (with E2f107172)
oocyte (with E2f1i2)
ovary (with Df(3R)e-BS2)
ovary | adult stage (with Df(3R)Exel6186)
peripheral nervous system
photoreceptor cell
polar body nucleus (with Df(2R)vg56)
posterior midgut primordium, with Scer\GAL4arm.PS
rhabdomere
terminal tracheal cell | somatic clone | third instar larval stage
trichogen cell, with Scer\GAL4pnr-MD237
unfertilized egg
wing, with Scer\GAL4Act88F.PD
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4ptc-559.1
wing blade, with Scer\GAL4Act88F.PD
wing blade, with Scer\GAL4en.PU
wing blade, with Scer\GAL4nub.PK
wing blade, with Scer\GAL4wg.PM
wing disc | cell non-autonomous, with Scer\GAL4ptc-559.1
wing disc | cell non-autonomous, with Scer\GAL4ptc-559.1, Scer\GAL80αTub84B.PL
wing disc | posterior | third instar larval stage, with Scer\GAL4en-e16E
wing disc | somatic clone
wing disc | third instar larval stage, with Scer\GAL4arm.PS
wing disc | wandering third instar larval stage
wing disc posterior compartment, with Scer\GAL4en-e16E
wing pouch, with Scer\GAL4Act88F.PD
wing vein, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\E2F2
9 of 15
Yes
Yes
1  
Hsap\E2F3
9 of 15
Yes
Yes
2  
Hsap\E2F1
8 of 15
No
Yes
1  
Hsap\E2F6
5 of 15
No
Yes
Hsap\E2F4
4 of 15
No
No
1  
Hsap\E2F5
3 of 15
No
No
1  
Hsap\E2F7
1 of 15
No
Yes
Hsap\E2F8
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\E2f2
9 of 15
Yes
Yes
Mmus\E2f3
9 of 15
Yes
Yes
Mmus\E2f1
8 of 15
No
Yes
Mmus\E2f6
5 of 15
No
Yes
Mmus\E2f4
4 of 15
No
No
Mmus\E2f5
1 of 15
No
No
Mmus\E2f7
1 of 15
No
Yes
Mmus\E2f8
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (8)
Rnor\E2f1
6 of 13
Yes
Yes
Rnor\E2f2
6 of 13
Yes
Yes
Rnor\E2f6
5 of 13
No
Yes
Rnor\E2f3
3 of 13
No
Yes
Rnor\E2f4
3 of 13
No
No
Rnor\E2f5
2 of 13
No
No
Rnor\E2f7
1 of 13
No
Yes
Rnor\E2f8
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\e2f1
5 of 12
Yes
Yes
Xtro\e2f3
5 of 12
Yes
Yes
Xtro\e2f4
1 of 12
No
No
Xtro\e2f5
1 of 12
No
No
Xtro\e2f6
1 of 12
No
Yes
Xtro\e2f7
1 of 12
No
Yes
Xtro\e2f8
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\si:ch211-160f23.5
9 of 15
Yes
Yes
Drer\e2f3
7 of 15
No
Yes
Drer\si:ch211-195d17.2
4 of 15
No
Yes
Drer\e2f4
3 of 15
No
No
Drer\e2f1
2 of 15
No
Yes
Drer\e2f5
2 of 15
No
No
Drer\e2f7
1 of 15
No
Yes
Drer\e2f8
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\efl-2
5 of 15
Yes
Yes
Cele\efl-1
4 of 15
No
No
Cele\efl-3
1 of 15
No
Yes
Cele\F46B6.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\E2F1
5 of 9
Yes
Yes
Atha\E2F3
5 of 9
Yes
Yes
Atha\ATE2F2
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909BJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011114
Drosophila simulans
Dsim\GD19970
Drosophila sechellia
Dsec\GM11000
Drosophila erecta
Dere\GG14417
Drosophila yakuba
Dyak\GE24969
Drosophila ananassae
Dana\GF17810
Drosophila pseudoobscura pseudoobscura
Dpse\GA19549
Drosophila persimilis
Dper\GL21507
Drosophila willistoni
Dwil\GK12076
Drosophila virilis
Dvir\GJ23948
Drosophila mojavensis
Dmoj\GI23766
Drosophila grimshawi
Dgri\GH19495
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509L2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017217
Glossina morsitans
Tsetse fly
Gmor\GMOY011912
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05047
Mayetiola destructor
Hessian fly
Mdes\Mdes006668
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012817
Anopheles darlingi
American malaria mosquito
Adar\ADAC004858
Anopheles gambiae
Malaria mosquito
Agam\AGAP001978
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006972
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0ANC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BmE2F1
Danaus plexippus
Monarch butterfly
Dple\DPOGS208741-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015237
Apis florea
Little honeybee
Aflo\2251559700
Apis mellifera
Western honey bee
Amel\GB42706
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22021
Bombus terrestris
Buff-tailed bumblebee
Bter\15210646
Linepithema humile
Argentine ant
Lhum\LH16032
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000229
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006113
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10638
Tribolium castaneum
Red flour beetle
Tcas\TC005074
Pediculus humanus
Human body louse
Phum\PHUM220810
Rhodnius prolixus
Kissing bug
Rpro\RPRC000866
Cimex lectularius
Bed bug
Clec\CLEC003832
Cimex lectularius
Bed bug
Clec\CLEC027011
Cimex lectularius
Bed bug
Clec\CLEC000427
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004845
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0AK1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009756
Ixodes scapularis
Black-legged tick
Isca\ISCW005631
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82363.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g01610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_52662
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
E2f2
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    E2F2; E2F transcription factor 2
    9 of 15
    600426
         
        E2F3; E2F transcription factor 3
        9 of 15
        600427
             
            E2F1; E2F transcription factor 1
            8 of 15
            189971
                 
                E2F6; E2F transcription factor 6
                5 of 15
                602944
                    E2F4; E2F transcription factor 4
                    4 of 15
                    600659
                         
                        E2F5; E2F transcription factor 5
                        3 of 15
                        600967
                             
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Show neighbor-neighbor interactions:
                            Select Layout:
                            Legend:
                            Protein
                            RNA
                            Selected Interactor(s)
                            Interactions Browser
                            View in Interactions Browser
                            Please see the Physical Interaction reports below for full details
                            protein-protein
                            Physical Interaction
                            Assay
                            References
                            E2f1 - CG13287
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - CG31612
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - CG33213
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - CG34376
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - Cdk8
                            pull down, anti tag western blot
                            (Morris et al., 2008)
                            E2f1 - Dp
                            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, pull down, autoradiography, coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
                            (Rhee et al., 2014, Weng et al., 2003, Du et al., 1996, Dynlacht et al., 1994)
                            E2f1 - E(spl)mδ-HLH
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - Ets65A
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - Orc1
                            pull down, western blot
                            (Bosco et al., 2001)
                            E2f1 - Orc2
                            pull down, western blot
                            (Bosco et al., 2001)
                            E2f1 - Rbf
                            anti tag coimmunoprecipitation, anti tag western blot, two hybrid, anti bait coimmunoprecipitation, western blot, pull down, coimmunoprecipitation, autoradiography, peptide massfingerprinting, experimental knowledge based
                            (Kim et al., 2018, Rhee et al., 2014, Ran et al., 2013, Acharya et al., 2010, Ahlander et al., 2008, Lu et al., 2007, Shibutani et al., 2007, Taylor-Harding et al., 2004, Weng et al., 2003, Du et al., 1996)
                            E2f1 - Su(z)12
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - Trl
                            anti tag coimmunoprecipitation, anti tag western blot
                            (Bayarmagnai et al., 2012)
                            E2f1 - dom
                            anti bait coimmunoprecipitation, western blot
                            (Lu et al., 2007)
                            E2f1 - foxo
                            two hybrid array
                            (Shokri et al., 2019)
                            E2f1 - l(3)mbt
                            anti tag coimmunoprecipitation, western blot
                            (Lu et al., 2007)
                            E2f1 - sd
                            anti tag coimmunoprecipitation, western blot, pull down
                            (Zhang et al., 2017)
                            E2f1 - slmb
                            pull down, autoradiography
                            (Heriche et al., 2003)
                            RNA-RNA
                            Physical Interaction
                            Assay
                            References
                            E2f1 - mir-184
                            western blot, luminiscence technology, necessary binding region
                            (Gehrke et al., 2010)
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            esyN Network Key:
                            Suppression
                            Enhancement
                            View in Interactions Browser
                            Please look at the allele data for full details of the genetic interactions
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            E2f1
                            suppressible
                            AGO1
                            (Li and Lu, 2009)
                            E2f1
                            suppressible
                            arm
                            (Morris et al., 2008)
                            E2f1
                            enhanceable
                            Asx
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            Asx
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            B52
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            bel
                            (Ambrus et al., 2009, Ambrus et al., 2007)
                            Dp|E2f1
                            enhanceable
                            brm
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            brm
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            cass
                            (Morris et al., 2006)
                            E2f1
                            suppressible
                            Cdk4|CycD
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            Cdk8
                            (Morris et al., 2008)
                            E2f1
                            suppressible
                            CycA
                            (Ji et al., 2012)
                            E2f2|E2f1
                            suppressible
                            CycE
                            (Weng et al., 2003)
                            E2f1
                            suppressible
                            CycE
                            (Kim et al., 2018, Ji et al., 2012)
                            E2f1
                            enhanceable
                            CycE
                            (Royzman et al., 1999, Royzman et al., 1997)
                            Dp|E2f1
                            suppressible
                            CycE
                            (Duronio et al., 1996)
                            E2f1
                            suppressible
                            Dark
                            (Morris et al., 2006)
                            E2f1
                            enhanceable
                            Diap1
                            (Morris et al., 2006)
                            Dp|E2f1
                            enhanceable
                            Dl
                            (Baonza and Freeman, 2005)
                            E2f1
                            suppressible
                            Doa
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Dp
                            (Morris et al., 2006, Frolov et al., 2001)
                            E2f1
                            enhanceable
                            Dp
                            (Morris et al., 2006, Neufeld et al., 1998)
                            E2f1
                            suppressible
                            E2f2
                            (Ambrus et al., 2007, Frolov et al., 2001)
                            Dp|E2f1
                            enhanceable
                            E(E2f)2B
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            e(Pc)84DE
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            E(Pc)
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            E(Pc)
                            (Ji et al., 2012)
                            Dp|E2f1
                            enhanceable
                            ebi
                            (Boulton et al., 2000)
                            E2f1
                            suppressible
                            eff
                            (Ji et al., 2012)
                            Dp|E2f1
                            enhanceable
                            Egfr
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            esc
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            gfzf
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            hid
                            (Davidson and Duronio, 2012)
                            E2f1
                            suppressible
                            His2Av
                            (Ji et al., 2012)
                            E2f1|Dp
                            enhanceable
                            His2Av
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            htt
                            (Dietz et al., 2015)
                            E2f1
                            suppressible
                            kis
                            (Ji et al., 2012)
                            Dp|E2f1
                            enhanceable
                            ksh-15
                            (Staehling-Hampton et al., 1999)
                            Dp|E2f1
                            enhanceable
                            ksh-16
                            (Staehling-Hampton et al., 1999)
                            Dp|E2f1
                            enhanceable
                            ksh-17
                            (Staehling-Hampton et al., 1999)
                            Dp|E2f1
                            enhanceable
                            ksh-18
                            (Staehling-Hampton et al., 1999)
                            Dp|E2f1
                            enhanceable
                            ksh-19
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            l(3)mbt
                            (Ambrus et al., 2009)
                            E2f1
                            enhanceable
                            Mi-2
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            Mi-2
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            mir-11
                            (Truscott et al., 2014, Truscott et al., 2011)
                            Dp|E2f1
                            suppressible
                            mir-11
                            (Truscott et al., 2014, Truscott et al., 2011)
                            E2f1|Dp
                            enhanceable
                            mir-ban
                            (Brennecke et al., 2003)
                            Dp|E2f1
                            enhanceable
                            mor
                            (Staehling-Hampton et al., 1999)
                            Dp|E2f1
                            suppressible
                            Nos
                            (Kuzin et al., 2000)
                            Dp|E2f1
                            enhanceable
                            Nos
                            (Stasiv et al., 2004)
                            Dp|E2f1
                            enhanceable
                            osa
                            (Staehling-Hampton et al., 1999)
                            E2f1|Dp
                            enhanceable
                            osa
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            pan
                            (Morris et al., 2008)
                            E2f1|Dp
                            enhanceable
                            Pc
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            Pc
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            pho
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            pho
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            piwi
                            (Li and Lu, 2009)
                            Dp|E2f1
                            enhanceable
                            pjc-16
                            (Staehling-Hampton et al., 1999)
                            Dp|E2f1
                            enhanceable
                            pnt
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            Pvf1
                            (Bilak et al., 2014)
                            Dp|E2f1
                            enhanceable
                            Ras85D
                            (Staehling-Hampton et al., 1999)
                            E2f1|Dp
                            enhanceable
                            Rbf
                            (Du and Dyson, 1999)
                            E2f1
                            suppressible
                            Rbf
                            (Moon et al., 2008, Morris et al., 2006, Du, 2000)
                            Dp|E2f1
                            enhanceable
                            rl
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            Scm
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            sgg
                            (Morris et al., 2008)
                            E2f1
                            suppressible
                            Slimp
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            smo
                            (Ambrus et al., 2007)
                            Dp|E2f1
                            enhanceable
                            spen
                            (Staehling-Hampton et al., 1999)
                            E2f1|Dp
                            enhanceable
                            spen
                            (Staehling-Hampton et al., 1999)
                            E2f1
                            suppressible
                            Su(E1)-A
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-B
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-C
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-D
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-E
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-F
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-G
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-H
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-I
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-J
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-K
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-L
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-M
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-N
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(E1)-O
                            (Ambrus et al., 2009)
                            E2f1
                            suppressible
                            Su(z)2
                            (Ji et al., 2012)
                            E2f1|Dp
                            enhanceable
                            Su(z)2
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            Su(z)2
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            Su(z)12
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            tara
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            tara
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            Tie
                            (Bilak et al., 2014)
                            E2f1
                            suppressible
                            tou
                            (Ji et al., 2012)
                            E2f1
                            enhanceable
                            tou
                            (Ji et al., 2012)
                            E2f1
                            suppressible
                            trx
                            (Ji et al., 2012)
                            Dp|E2f1
                            suppressible
                            vg
                            (Legent et al., 2006)
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            arm
                            suppressible
                            Dp|E2f1
                            (Morris et al., 2008)
                            AspRS
                            suppressible
                            E2f1
                            (Galloni and Edgar, 1999)
                            bam
                            suppressible
                            E2f1
                            (Jin et al., 2008)
                            blw
                            suppressible
                            E2f1
                            (Galloni and Edgar, 1999)
                            bonsai
                            suppressible
                            E2f1
                            (Galloni and Edgar, 1999)
                            crol
                            suppressible
                            E2f1
                            (Mitchell et al., 2008)
                            CycA|Cdk1
                            suppressible
                            E2f1
                            (Hayashi and Yamaguchi, 1999)
                            CycE
                            enhanceable
                            E2f1
                            (Brumby et al., 2004, Lane et al., 2000, Secombe et al., 1998)
                            CycE
                            suppressible
                            Dp|E2f1
                            (Wang and Kalderon, 2009)
                            Dref
                            suppressible
                            E2f1
                            (Hirose et al., 2001)
                            E2f2
                            enhanceable
                            E2f1
                            (Weng et al., 2003, Frolov et al., 2001)
                            E2f2
                            suppressible
                            E2f1
                            (Cayirlioglu et al., 2003, Frolov et al., 2001)
                            eIF4A
                            suppressible
                            E2f1
                            (Galloni and Edgar, 1999)
                            Imp
                            enhanceable
                            E2f1
                            (Geng and MacDonald, 2007)
                            Lrrk
                            suppressible
                            E2f1
                            (Gehrke et al., 2010)
                            milou
                            suppressible
                            E2f1
                            (Galloni and Edgar, 1999)
                            mir-let7
                            suppressible
                            E2f1
                            (Gehrke et al., 2010)
                            Myb
                            suppressible
                            Dp|E2f1
                            (Fitzpatrick et al., 2002)
                            Nsf2
                            suppressible
                            E2f1
                            (Laviolette et al., 2005)
                            pbl
                            enhanceable
                            E2f1
                            (Gregory et al., 2007)
                            Ras85D|scrib
                            suppressible
                            E2f1
                            (Brumby and Richardson, 2003)
                            Rbf
                            suppressible
                            E2f1
                            (Kwon et al., 2013, Weng et al., 2003, Du, 2000)
                            Rbf
                            suppressible
                            Dp|E2f1
                            (Kuzin et al., 2000, Du et al., 1996)
                            Rbf|gig
                            suppressible
                            E2f1
                            (Li et al., 2010)
                            Rbf|dap
                            suppressible
                            E2f1
                            (Weng et al., 2003)
                            Rbf|Tsc1
                            suppressible
                            E2f1
                            (Hsieh et al., 2010)
                            Rbf|Stam
                            suppressible
                            E2f1
                            (Sheng et al., 2016)
                            Rbf|rno
                            suppressible
                            E2f1
                            (Steele et al., 2009)
                            RpL30
                            suppressible
                            E2f1
                            (Galloni and Edgar, 1999)
                            sd
                            enhanceable
                            E2f1
                            (Delanoue et al., 2004)
                            shot
                            suppressible
                            E2f1
                            (Sun et al., 2019)
                            slmb
                            suppressible
                            E2f1
                            (Heriche et al., 2003)
                            trol
                            suppressible
                            Dp|E2f1
                            (Caldwell and Datta, 1998)
                            Tsc1
                            enhanceable
                            E2f1|Rbf
                            (Hsieh et al., 2010)
                            Tsc1
                            enhanceable
                            E2f1
                            (Hsieh et al., 2010)
                            vg
                            suppressible
                            E2f1
                            (Delanoue et al., 2004)
                            vg
                            suppressible
                            Dp|E2f1
                            (Legent et al., 2006)
                            External Data
                            Subunit Structure (UniProtKB)
                            Heterodimer of E2f and Dp. Cooperates to give sequence-specific DNA binding and optimal trans-activation. Interacts with PCNA.
                            (UniProt, Q27368 )
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            MIST (genetic) - An integrated Molecular Interaction Database
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            External Data
                            Linkouts
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            3R
                            Recombination map
                            3-72
                            Cytogenetic map
                            93E9-93F1
                            Sequence location
                            3R:21,620,304..21,660,871 [-]
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            93E9-93F1
                            Limits computationally determined from genome sequence between P{PZ}InR05545 and P{PZ}tsl00617
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            93E8-93E9
                            (determined by in situ hybridisation)
                            (Spradling et al., 1999)
                            93E-93E
                            (determined by in situ hybridisation)
                            (Seum et al., 1996, Duronio et al., 1995, Spierer et al., 1995)
                            86C3-86C4
                            (BDGP Project Members, 1994-1999)
                            Experimentally Determined Recombination Data
                            Location

                            3-72

                            (FlyBase, 2016)

                            3-74.5

                            (Comeron et al., 2012)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (36)
                            Genomic Clones (29)
                            cDNA Clones (108)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                            Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               

                              polyclonal

                              (Unnikannan et al., 2020, Song et al., 2018, Baumgardt et al., 2014, Korenjak et al., 2012)
                              Commercially Available Antibodies
                               
                              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of

                              Source for identity of: E2f1 E2f

                              (FlyBase, 2009-)
                              Source for database merge of
                              Additional comments

                              'E2f' renamed to 'E2f1' to: i) reflect usage in the literature; ii) better distinguish it from the 'E2f2' gene; iii) reflect preference of authors Dyson and Duronio who originally characterized the gene in FBrf0073014 and FBrf0081967.

                              (FlyBase, 2009-)

                              mir-998 and mir-11 are both located in the same intron of E2f.

                              (Stark et al., 2007)

                              mir-998 is located within an intron of E2f.

                              (Stark et al., 2007)
                              Other Comments

                              dsRNA has been made from templates generated with primers directed against this gene. RNAi of E2f results in increased arborization of ddaD and ddaE neurons. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

                              (Parrish et al., 2006)

                              RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

                              (Kleino et al., 2005)

                              RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                              (Boutros et al., 2004)

                              RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                              (Boutros et al., 2004)

                              E2f as part of the E2f-Rb complexes has a role in the down regulation of CycE during the gap phase of endocycling cells in normal development.

                              (Weng et al., 2003)

                              E2f transcriptional activity in nurse cells is essential for thr robust synthesis of S phase transcripts that are deposited into the oocyte. E2f is needed to limit the replication of heterochromatin in nurse cells. E2f is required for nurse cell nuclear envelope breakdown and apoptosis.

                              (Royzman et al., 2002)

                              Identified with: LP10386 (BDGP-DGC) <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

                              (BDGP Project Members, 2000-)

                              Most, if not all, of the function of Rbf during development is mediated through E2f. E2f functions primarily as a transcription activator rather than a co-repressor of Rbf during development.

                              (Du, 2000)

                              Identification: One of a collection of genes identified with defective larval growth that extend larval life.

                              (Galloni and Edgar, 1999)

                              Both Dp and E2f are necessary for viability and mutations in the genes cause lethality at the larval\pupal stage. E2f is required for wild-type growth in mitotic and polytene tissues. Mutant phenotypes reveal that both genes promote progression of the cell cycle.

                              (Royzman et al., 1997)

                              In vitro binding studies of E2f and Dp to the DNApol-α180 promoter region reveals each of the E2f binding sites plays a distinct role as positive or negative element in the regulation of the DNApol-α180 promoter during development.

                              (Yamaguchi et al., 1997)

                              Endogenous E2f falls from high to very low levels as cells initiate DNA synthesis during a developmentally regulated G1-S transition in the eye disc. Ectopic E2f expression drives many otherwise quiescent cells to enter S phase, subsequently these cells express rpr and die. Ectopic E2f expression during the S phase in normally cycling cells blocks their re-entry into S phase in the following cell cycle. These results show that an elevation in the level of E2f is sufficient to induce imaginal disc cells to enter S phase. Also they suggest that the down regulation of E2f upon entry into S phase may be essential to prevent the induction of apoptosis.

                              (Asano et al., 1996)

                              E2f is required at multiple stages of development and may have an important function in post-mitotic cells in addition to its role during cell proliferation.

                              (Brook et al., 1996)

                              Ectopic expression of E2f together with Dp induces cell proliferation and cell death in the eye.

                              (Du et al., 1996)

                              E2f transcription factor-induced S phase requires CycE.

                              (Duronio et al., 1996)

                              Deduced protein sequence of transcripts from the E(var)93E locus identifies the E2f gene.

                              (Seum et al., 1996)

                              Mutations of E2f dominantly enhance position effect variegation, as tested with w and y variegating rearrangements. Overexpression suppresses position-effect variegation.

                              (Seum et al., 1996)

                              During G1 of cycle 17 in the endocycling cells, E2f activation is independent of CycE, whereas CycE expression requires E2f. In the CNS CycE is expressed by a route independent of E2f, and the activation of E2f depends on CycE. The hierarchical relationship of CycE and E2f is reversed by tissue-specific distinctions in the mode of expression of CycE.

                              (Duronio and O'Farrell, 1995)

                              E2f is essential in most cells for a G1-S transcriptional program and for G1-S progression.

                              (Duronio et al., 1995)

                              Analysis of expression patterns of E2f indicates in late stage embryos the protein is present in a restricted group of neural cells. In early embryos the protein is widely expressed in a segment restricted pattern. Distinct expression patterns of Dp and E2f suggest that the formation of Dp/E2f heterodimers is subject to complex regulatory cues.

                              (Hao et al., 1995)

                              A dominant modifier of position effect variegation.

                              (Spierer et al., 1995)

                              Dp and E2f gene products interact and cooperate to give sequence specific DNA binding and optimal trans-activation. This suggests that E2f may be composed of heterodimers and may be regulated by retinoblastoma proteins.

                              (Dynlacht et al., 1994)

                              The product of E2f binds to an E2F recognition site and can activate transcription of Ecol\CAT reporter plasmids in Drosophila cells. The transcriptional activation function can be found in C-terminal sequences. A potential gene target for E2f is DNA-polymerase α.

                              (Ohtani and Nevins, 1994)
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 93 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              DRscDB
                              EMBL-EBI Single Cell Expression Atlas
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              MARRVEL_MODEL
                              modMine - A data warehouse for the modENCODE project
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                              MIST (genetic) - An integrated Molecular Interaction Database
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Synonyms and Secondary IDs (30)
                              Reported As
                              Symbol Synonym
                              CG6376
                              (Kim et al., 2021, Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Grieder et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Laviolette et al., 2005, Kim et al., 2004, Norga et al., 2003)
                              DRTF1/E2F
                              (Hao et al., 1995)
                              DmE2F-1
                              (Hao et al., 1995)
                              Dp
                              (Glavic et al., 2009)
                              E(Sev-CycE)3A
                              (Lane et al., 2000)
                              E(var)3-93E
                              (Elgin and Reuter, 2013, Sun et al., 2000, Seum et al., 1996, Spierer et al., 1995)
                              E(var)3-95E
                              (Dietz et al., 2015, Wallrath, 1998)
                              E(var)93E
                              E2F
                              (Li and Hidalgo, 2020, Sun et al., 2019, Tokusumi et al., 2015, Bhaskar et al., 2014, Kwon et al., 2013, Losick et al., 2013, Adamson and Lajeunesse, 2012, Ge et al., 2012, Korenjak et al., 2012, Valadez-Graham et al., 2012, Wang et al., 2012, Chen et al., 2011, Slattery et al., 2011, Turner et al., 2011, Walker et al., 2011, Buttitta et al., 2010, Herranz et al., 2010, Lee et al., 2010, Glavic et al., 2009, Lyulcheva et al., 2008, Mitchell et al., 2008, Oktaba et al., 2008, Frolov et al., 2007, Sandmann et al., 2007, Buttitta and Edgar, 2006, Mukherjee et al., 2006, Parrish et al., 2006, Umetsu et al., 2006, Alvarez-Garcia and Miska, 2005, Bandura, 2005, Kleino et al., 2005, Kohzaki and Murakami, 2005, Sundaram, 2005, Thomas, 2005, Kearney et al., 2004, Kupsco et al., 2004, Moon et al., 2004, Tower, 2004, Volkova et al., 2004, Bergmann and Lane, 2003, Davidson, 2003, Heriche et al., 2003, Kramer et al., 2003, Ryoo and Steller, 2003, Thacker et al., 2003, Folberg-Blum et al., 2002, Frolov et al., 2001, Hirose et al., 2001, Potter and Xu, 2001, Datar et al., 2000, Li and Vaessin, 2000, Manak et al., 2000, Oldham et al., 2000, Asano and Wharton, 1999, Datar and Edgar, 1999, Enikolopov et al., 1999, Galloni and Edgar, 1999, Hayashi and Yamaguchi, 1999, Hinds, 1999, Whittaker et al., 1999, Britton and Edgar, 1998, Caldwell and Datta, 1998, Follette et al., 1998, Sasaki, 1998.3.3, Sass and Henikoff, 1998, Su and O'Farrell, 1998, Wallrath, 1998, Royzman et al., 1997, Royzman et al., 1997, Yamaguchi et al., 1997, Asano et al., 1996, Lin et al., 1996, Dynlacht et al., 1994, Dyson, 1994.6.6)
                              E2F transcription factor 1
                              (Jin et al., 2016)
                              E2F-1
                              (Taniue et al., 2010, McNairn and Gilbert, 2003)
                              E2F1
                              (Besen-McNally et al., 2021, Kim et al., 2021, Jin et al., 2020, Mouawad et al., 2020, Moskalev et al., 2018, Otsuki and Brand, 2018, Song et al., 2018, Romero-Pozuelo et al., 2017, Tokusumi et al., 2017, Zhang et al., 2017, Flegel et al., 2016, Cao et al., 2015, Chen et al., 2014, Handke et al., 2014, Zielke et al., 2014, Kawamori et al., 2013, Lim et al., 2013, Ran et al., 2013, Zhou and Luo, 2013, Liu et al., 2012, Klusza and Deng, 2011, Laprise, 2011, Herranz et al., 2010, Maqbool et al., 2010, Rogers et al., 2009, Tanaka-Matakatsu et al., 2009, Wang and Kalderon, 2009, Bowman et al., 2008, Herranz et al., 2008, Mitchell et al., 2008, Sun et al., 2008, Zielke et al., 2008, Zielke et al., 2008, Garcia et al., 2007, Ji et al., 2007, Morris and Dyson, 2007, Sun and Deng, 2006, Bandura et al., 2005, Baonza and Freeman, 2005, Claycomb and Orr-Weaver, 2005, Hyun et al., 2005, Parakati and Dimario, 2005, Bandura et al., 2004, Brumby et al., 2004, Emmerich et al., 2004, Lewis et al., 2004, Xin et al., 2002, Cha et al., 2001, Edgar and Orr-Weaver, 2001)
                              E2f
                              (Curt et al., 2019, Fu et al., 2017, Bivik et al., 2016, Jin et al., 2016, Baëza et al., 2015, Bivik et al., 2015, Panneton et al., 2015, Sanchez-Alvarez et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Ghavi-Helm et al., 2014, Mondal et al., 2014, Rhee et al., 2014, Singer et al., 2014, Bonke et al., 2013, Schertel et al., 2013, Shen et al., 2013, Southall et al., 2013, Joyce et al., 2012, Kozhevnikova et al., 2012, Zhai et al., 2012, Abruzzi et al., 2011, Bangi et al., 2011, Baxley et al., 2011, Carreira et al., 2011, Friedman et al., 2011, Richter et al., 2011, Sala et al., 2011, Arancio et al., 2010, Sinenko et al., 2010, Southall and Brand, 2009, Protzer et al., 2008, Gregory et al., 2007, Grieder et al., 2007, Isogai et al., 2007, Quinones-Coello, 2007, Stark et al., 2007, Stark et al., 2007, Badal et al., 2006, Choksi et al., 2006, Molnar et al., 2006, Morris et al., 2006, Laviolette et al., 2005, Liebl and Featherstone, 2005, Boulton et al., 2000)
                              E2f1
                              (Cattenoz et al., 2021, Fabian et al., 2021, Gogia et al., 2021, Rust et al., 2020, Zhao et al., 2020, Burguete et al., 2019, Grendler et al., 2019, Khan et al., 2019, Meltzer et al., 2019, Mouawad et al., 2019, Shokri et al., 2019, Ariss et al., 2018, Kwon et al., 2018, Wang et al., 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Xiang et al., 2017, Zhang et al., 2017, Bahrampour and Thor, 2016, Dominado et al., 2016, Kockel et al., 2016, Yadav et al., 2016, Afonso et al., 2015, Doggett et al., 2015, Kohlmaier et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Wang and Baker, 2015, Handke et al., 2014, Davidson and Duronio, 2012, Sloan et al., 2012, Acharya et al., 2010, Reddy et al., 2010, Davidson et al., 2008, Shibutani et al., 2008, Geng and MacDonald, 2007, Shibutani et al., 2007, Shibutani et al., 2007, Khurana et al., 2006, Morris et al., 2006, Kohzaki and Murakami, 2005, Muzzopappa and Wappner, 2005, Tower, 2004, Cayirlioglu et al., 2003, Key et al., 2003)
                              Evar(3)164
                              (Seum et al., 1995)
                              dE2F
                              (Herranz et al., 2010, Chia et al., 2008, Herranz et al., 2008, Rowland and Bernards, 2006, Berger et al., 2005, Chia and Prokopenko, 2005, Kohzaki and Murakami, 2005, Jorgensen and Tyers, 2004, Secombe et al., 2004, Hwang et al., 2002, Cayirlioglu and Duronio, 2001, Kwon et al., 2001, Yoshida et al., 2001, Cayirlioglu et al., 2000, Coelho and Leevers, 2000, Kuzin et al., 2000, Myster and Duronio, 2000, Weinkove and Leevers, 2000, Whittaker et al., 2000, Du and Dyson, 1999, Duronio, 1999, Hayashi and Yamaguchi, 1999, Hirose et al., 1999, Polymenis and Schmidt, 1999, Royzman et al., 1999, Staehling-Hampton et al., 1999, Tao et al., 1999, Britton and Edgar, 1998, Duronio et al., 1998, Duronio et al., 1998, Duronio et al., 1998, Dyson, 1998, Helin, 1998, Johnston and Edgar, 1998, Milan, 1998, Neufeld and Edgar, 1998, Neufeld et al., 1998, Neufeld et al., 1998, Royzman and Orr-Weaver, 1998, Sawado et al., 1998, Sawado et al., 1998, Secombe et al., 1998, Secombe et al., 1998, Skaer, 1998, Secombe et al., 1997, Seum, 1997.2.11, Seum, 1997.2.11, Brook et al., 1996, De Rubertis et al., 1996, Du and Dyson, 1996, Du et al., 1996, Du et al., 1996, Duronio et al., 1996, Seum et al., 1996, Duronio and O'Farrell, 1995, Duronio et al., 1995, Yamaguchi et al., 1995)
                              dE2F1
                              (Murcia et al., 2019, Kim et al., 2018, Dietz et al., 2015, Bilak et al., 2014, Korenjak et al., 2014, Gordon et al., 2013, Unhavaithaya et al., 2013, Korenjak et al., 2012, Lee et al., 2012, Miles et al., 2012, Truscott et al., 2011, Ambrus and Frolov, 2010, Herranz et al., 2010, Hsieh et al., 2010, Lee et al., 2010, Milet et al., 2010, Steele et al., 2009, Ahlander et al., 2008, Goulev et al., 2008, Jin et al., 2008, Moon et al., 2008, Morris et al., 2008, Rimkus et al., 2008, Sun et al., 2008, Escudero and Freeman, 2007, Hartl et al., 2007, Kugler and Nagel, 2007, Lu et al., 2007, Shi and Krek, 2007, Tountas and Fortini, 2007, Ji et al., 2006, Legent et al., 2006, Legent et al., 2006, Morris et al., 2006, Baonza and Freeman, 2005, Attwooll et al., 2004, Coffman, 2004, Delanoue et al., 2004, Legent et al., 2004, Lipsick, 2004, Taylor-Harding et al., 2004, Zraly et al., 2004, Dimova et al., 2003, Du et al., 2003, Johnston and Sanders, 2003, Lee and Orr-Weaver, 2003, Reis, 2003, Reis and Edgar, 2003, Thacker et al., 2003, Weng et al., 2003, Morris et al., 2002, Reis and Edgar, 2002, Royzman et al., 2002, Bosco et al., 2001, Lee et al., 2001, Park et al., 2001, Harbour and Dean, 2000, Lane et al., 2000, Du, 1999)
                              dE2f
                              (Suzuki et al., 2009, Secombe et al., 2007, Baonza and Freeman, 2005, Sasaki et al., 1999)
                              dE2f1
                              (Bervoets et al., 2019, Xie et al., 2015, Bhaskar et al., 2014, Truscott et al., 2014, Ji et al., 2012, Gordon and Du, 2011, Li and Lu, 2009, Morris et al., 2006, Korenjak and Brehm, 2005, Moon et al., 2005, Morris and Dyson, 2004)
                              de2f1
                              (Kim et al., 2018, Bradley-Gill et al., 2016, Sheng et al., 2016, Wei et al., 2015, Bilak et al., 2014, Korenjak et al., 2012, Hsieh et al., 2010, Li et al., 2010, Nicolay et al., 2010, Ambrus et al., 2009, Nicholson et al., 2009, Steele et al., 2009, Longworth et al., 2008, Moon et al., 2008, Nicolay and Frolov, 2008, Ambrus et al., 2007, Frolov et al., 2007, Herr et al., 2007, Moon et al., 2006, Rasheva et al., 2006, Rowland and Bernards, 2006, Frolov et al., 2005, Moon et al., 2005, Frolov et al., 2004, Moon et al., 2004, Dimova et al., 2003, Frolov et al., 2003, Frolov et al., 2003, Frolov et al., 2002, Frolov et al., 2001, Du, 2000)
                              def21
                              (Reis and Edgar, 2004)
                              drosE2F1
                              (Nevins, 1994.5.31, Ohtani and Nevins, 1994)
                              e2f
                              (Ge et al., 2012, Sinenko et al., 2010, Fung et al., 2003, Zhou and Steller, 2003)
                              e2f1
                              (Zhang et al., 2021, Wang et al., 2020, Zhang et al., 2015, Ikmi et al., 2014, Liu et al., 2014, Miles et al., 2014, Fausti et al., 2012, Miles et al., 2012, Buttitta et al., 2010, Gehrke et al., 2010, Buttitta et al., 2007, Brumby and Richardson, 2003)
                              l(3)07172
                              l(3)j3B1
                              l(3)j3C2
                              l(3)rM729
                              Name Synonyms
                              E2-promoter binding factor
                              (Morris et al., 2006)
                              E2F transcription factor
                              E2F transcription factor 1
                              Secondary FlyBase IDs
                              • FBgn0010918
                              • FBgn0011343
                              • FBgn0011351
                              • FBgn0011520
                              • FBgn0011767
                              • FBgn0013944
                              • FBgn0016652
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (508)