Odh, gfd, glutathione-dependent formaldehyde dehydrogenase
Please see the GBrowse view of Dmel\Fdh or the JBrowse view of Dmel\Fdh for information on other features
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Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
1.36 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
379 (aa); 80 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fdh using the Feature Mapper tool.
Comment: maternally deposited
Fdh transcripts were observed in all stages tested and appear to be abundant throughout the life span of the organism.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Fdh in GBrowse 2
3-50
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Activity change of the enzyme due to the influence of ethanol, starvation and ethanol stress is assayed.
The genomic organisation of the Fdh locus has been characterised.
No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.
Segmental aneuploids for gene dosage that are heterozygous for Fdh variants are produced and analysed for the purpose of gene localization.
Allelic frequencies have been determined between European and African populations. African populations show a greater genetic diversity, as measured by the number of alleles found. Within each geographic group there is a homogeneity of allele frequencies.
The structural gene for glutathione-dependent formaldehyde dehydrogenase (FDH), previously characterised as octanol dehydrogenase, a multimer of 109,000 molecular weight (Sieber, Fox and Ursprung, 1972); evidence for tetrameric structure in other Drosophila species (Pipkin, 1969); immunologically unrelated to ADH (Courtright, 1968). Preferred substrates are long-chain primary alcohols, with lesser activity on short-chain and branched-chain primary alcohols; inactive on secondary alcohols (Bremner et al., 1971). Enzyme activity higher in adults than in larvae or pupae (Debec, 1974); mobility also increases from larvae to pupae to adults (Hewitt, 1974). Fdh+ not a vital gene; homozygotes for null allele, FdhnNC1, viable and fertile (Voelker et al., 1980).
Ursprung.
